Michael Freissmuth

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Michael Freissmuth

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#406

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Michael Freissmuth

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#12212

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Philosophy

Michael Freissmuth's Degrees

PhD Pharmacology University of Vienna
Doctorate Medicine Medical University of Vienna

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Michael Freissmuth's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Natural products in drug discovery: advances and opportunities (2021) (1082)
G proteins control diverse pathways of transmembrane signaling 1 (1989) (362)
Laryngeal Recurrent Nerve Injury in Surgery for Benign Thyroid Diseases: Effect of Nerve Dissection and Impact of Individual Surgeon in More Than 27,000 Nerves at Risk (2002) (341)
Adenosine receptors: G protein-mediated signalling and the role of accessory proteins. (2002) (278)
Neuromonitoring in Thyroid Surgery: Prospective Evaluation of Intraoperative Electrophysiological Responses for the Prediction of Recurrent Laryngeal Nerve Injury (2004) (262)
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis (2013) (236)
Oligomerization of the Human Serotonin Transporter and of the Rat GABA Transporter 1 Visualized by Fluorescence Resonance Energy Transfer Microscopy in Living Cells* (2001) (227)
Amphetamines, new psychoactive drugs and the monoamine transporter cycle (2014) (209)
Stimulation of the Mitogen-activated Protein Kinase via the A2A-Adenosine Receptor in Primary Human Endothelial Cells* (1997) (198)
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. (1989) (178)
Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. (1999) (160)
Risk factors for postoperative bleeding after thyroid surgery (2012) (157)
Suramin analogues as subtype-selective G protein inhibitors. (1996) (147)
STAT1 acts as a tumor promoter for leukemia development. (2006) (143)
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. (1989) (139)
Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 ras -dependent Pathway* (1999) (134)
The Ubiquitin-Specific Protease Usp4 Regulates the Cell Surface Level of the A2a Receptor (2006) (131)
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design (2013) (129)
Inhibition of receptor/G protein coupling by suramin analogues. (1996) (129)
The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines* (2010) (128)
Reverse intrinsic activity of antagonists on G protein-coupled receptors. (1992) (127)
Binding of Calmodulin to the D2-Dopamine Receptor Reduces Receptor Signaling by Arresting the G Protein Activation Switch* (2000) (126)
G protein antagonists. (1999) (125)
Anomalous Dopamine Release Associated with a Human Dopamine Transporter Coding Variant (2008) (121)
Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. (2005) (118)
Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity. (1999) (114)
Gsalpha-selective G protein antagonists. (1998) (114)
Mutations within an Intramembrane Leucine Heptad Repeat Disrupt Oligomer Formation of the Rat GABA Transporter 1* (2002) (111)
Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. (1994) (110)
Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits. (1992) (108)
Interactions of the bovine brain A1-adenosine receptor with recombinant G protein alpha-subunits. Selectivity for rGi alpha-3. (1991) (105)
Identification of an Additional Interaction Domain in Transmembrane Domains 11 and 12 That Supports Oligomer Formation in the Human Serotonin Transporter* (2004) (104)
Concentrative Export from the Endoplasmic Reticulum of the γ-Aminobutyric Acid Transporter 1 Requires Binding to SEC24D* (2007) (101)
The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters* (2012) (97)
The Role of Zinc Ions in Reverse Transport Mediated by Monoamine Transporters* (2002) (93)
Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein. (1994) (93)
Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters☆ (2014) (88)
The Serotonin Transporter Is an Exclusive Client of the Coat Protein Complex II (COPII) Component SEC24C* (2011) (87)
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’), methamphetamine and d-amphetamine (2011) (86)
Kinetics of serum parathyroid hormone during and after thyroid surgery (2008) (86)
The A2A‐adenosine receptor: a GPCR with unique features? (2008) (86)
MAP Kinase Stimulation by cAMP Does Not Require RAP1 but SRC Family Kinases* (2002) (85)
Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. (2010) (84)
The reverse operation of Na+/Cl−‐coupled neurotransmitter transporters – why amphetamines take two to tango (2010) (83)
JunB inhibits proliferation and transformation in B-lymphoid cells. (2003) (82)
STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior (2015) (82)
Stimulation of human umbilical vein endothelial cell proliferation by A2‐adenosine and β2‐adrenoceptors (1995) (79)
Two Discontinuous Segments in the Carboxyl Terminus Are Required for Membrane Targeting of the Rat γ-Aminobutyric Acid Transporter-1 (GAT1)* (2004) (77)
Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding. (1991) (77)
Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides. (2000) (75)
Unifying Concept of Serotonin Transporter-associated Currents* (2011) (75)
Normal parathyroid hormone levels do not exclude permanent hypoparathyroidism after thyroidectomy. (2011) (71)
VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution. (2012) (70)
Truncation of the A1 Adenosine Receptor Reveals Distinct Roles of the Membrane-proximal Carboxyl Terminus in Receptor Folding and G Protein Coupling* (2003) (68)
TYK2 is a key regulator of the surveillance of B lymphoid tumors. (2004) (68)
G proteins as drug targets (1999) (68)
Species differences in A1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. (1995) (67)
The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter (2010) (67)
Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model (2013) (67)
Expression of two human beta-adrenergic receptors in Escherichia coli: functional interaction with two forms of the stimulatory G protein. (1991) (65)
Mapping of Calmodulin and Gβγ Binding Domains within the C-terminal Region of the Metabotropic Glutamate Receptor 7A* (2001) (64)
Antibodies Directed against Lewis-Y Antigen Inhibit Signaling of Lewis-Y Modified ErbB Receptors (2004) (63)
Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo (2013) (63)
Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter* (2010) (61)
Removal of the carboxy terminus of the A2A-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation (2002) (61)
Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells* (2011) (59)
Heterotrimeric G Protein-independent Signaling of a G Protein-coupled Receptor (2005) (59)
The Cyclin-dependent Kinase Inhibitor p21 cip1 Mediates the Growth Inhibitory Effect of Phorbol Esters in Human Venous Endothelial Cells* (1997) (58)
Intra- and postoperative parathyroid hormone-kinetics do not advocate for autotransplantation of discolored parathyroid glands during thyroidectomy. (2010) (58)
Evolution of Nerve Injury with Unexpected EMG Signal Recovery in Thyroid Surgery Using Continuous Intraoperative Neuromonitoring (2013) (56)
Oligomerization of neurotransmitter transporters: a ticket from the endoplasmic reticulum to the plasma membrane. (2006) (54)
The Human D2 Dopamine Receptor Synergizes with the A2A Adenosine Receptor to Stimulate Adenylyl Cyclase in PC12 Cells (2003) (53)
A Different Desensitization Pattern of Cardiac β‐Adrenoceptor Subtypes by Prolonged In Vivo Infusion of Isoprenaline (1989) (53)
Oligomer formation by Na+-Cl--coupled neurotransmitter transporters. (2003) (51)
Thiophosphorylation of the G protein beta subunit in human platelet membranes: evidence against a direct phosphate transfer reaction to G alpha subunits. (1996) (51)
Kinetics of Ternary Complex Formation with Fusion Proteins Composed of the A1-Adenosine Receptor and G Protein α-Subunits* (1999) (51)
Molecular Dissection of Dual Pseudosymmetric Solute Translocation Pathways in Human P-Glycoprotein (2011) (50)
Amphipathic alpha-helical structure does not predict the ability of receptor-derived synthetic peptides to interact with guanine nucleotide-binding regulatory proteins. (1993) (48)
Electron microscopic visualization of fluorescent signals in cellular compartments and organelles by means of DAB-photoconversion (2008) (47)
Ca2+/Calmodulin-dependent Protein Kinase IIα (αCaMKII) Controls the Activity of the Dopamine Transporter (2012) (46)
Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. (2008) (46)
Cocaine adulteration (2017) (46)
In Vivo Amphetamine Action is Contingent on αCaMKII (2014) (45)
Oligomerization of the γ-Aminobutyric Acid Transporter-1 Is Driven by an Interplay of Polar and Hydrophobic Interactions in Transmembrane Helix II* (2004) (44)
The Conserved Glutamate (Glu136) in Transmembrane Domain 2 of the Serotonin Transporter Is Required for the Conformational Switch in the Transport Cycle* (2006) (44)
A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter* (2015) (43)
A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter* (2014) (43)
Early relapse after operation for Graves' disease: postoperative hormone kinetics and outcome after subtotal, near-total, and total thyroidectomy. (1998) (42)
Pharmacochaperoning of the A1 Adenosine Receptor Is Contingent on the Endoplasmic Reticulum (2010) (42)
Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems (2018) (41)
Sec24- and ARFGAP1-Dependent Trafficking of GABA Transporter-1 Is a Prerequisite for Correct Axonal Targeting (2008) (40)
Inhibition of adenylyl cyclase by neuronal P2Y receptors (2002) (40)
Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C. (1992) (39)
Involvement of a Phorbol Ester-Insensitive Protein Kinase C in the α2-Adrenergic Inhibition of Voltage-Gated Calcium Current in Chick Sympathetic Neurons (1996) (39)
Role of G proteins in transmembrane signaling. (1988) (39)
Defining the blanks – Pharmacochaperoning of SLC6 transporters and ABC transporters? (2014) (39)
Recruitment of a Cytoplasmic Chaperone Relay by the A2A Adenosine Receptor* (2013) (38)
From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor. (2011) (38)
Restricted Collision Coupling of the A2A Receptor Revisited (2008) (38)
P2‐, but not P1‐purinoceptors mediate formation of 1,4,5‐inositol trisphosphate and its metabolites via a pertussis toxin‐insensitive pathway in the rat renal cortex (1990) (37)
Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G2–M Cell-Cycle Progression (2012) (37)
Suramin and suramin analogs activate skeletal muscle ryanodine receptor via a calmodulin binding site. (1999) (36)
The Carboxyl Terminus of the Gα-Subunit Is the Latch for Triggered Activation of Heterotrimeric G Proteins (2006) (35)
Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade (2011) (35)
Switching the Clientele (2013) (35)
Targeting PI3Kδ (2013) (34)
Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter* (2016) (34)
The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas. (2011) (33)
Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones*♦ (2016) (33)
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis (2016) (33)
Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism (2017) (32)
Activation of the skeletal muscle ryanodine receptor by suramin and suramin analogs. (1996) (32)
Subtype-Specific Differences in Corticotropin-Releasing Factor Receptor Complexes Detected by Fluorescence Spectroscopy (2009) (32)
Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif (2008) (32)
Inhibition of Adenylyl and Guanylyl Cyclase Isoforms by the Antiviral Drug Foscarnet* (2001) (32)
Expression of Gsα in Escherichia coli: purification and properties of two forms of the protein (1989) (31)
A quantitative model of amphetamine action on the 5-HT transporter (2014) (31)
Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies. (2008) (31)
Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter* (2015) (31)
Inhibition of Xenograft Tumor Growth and Down-Regulation of ErbB Receptors by an Antibody Directed against Lewis Y Antigen (2006) (30)
Differential uncoupling of A1 adenosine and D2 dopamine receptors by suramin and didemethylated suramin (NF037). (1998) (30)
Axonal Targeting of the Serotonin Transporter in Cultured Rat Dorsal Raphe Neurons Is Specified by SEC24C-Dependent Export from the Endoplasmic Reticulum (2014) (29)
PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes (2012) (29)
The role of a low β1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands (1987) (28)
Biased inhibition by a suramin analogue of A1-adenosine receptor/G protein coupling in fused receptor/G protein tandems: the A1-adenosine receptor is predominantly coupled to Goα in human brain (2001) (28)
Effects of Ischemia on the Canine Myocardial β-Adrenoceptor‐Linked Adenylate Cyclase System (1987) (28)
Stimulation of natural killer activity in peripheral blood lymphocytes of healthy donors and melanoma patients in vitro: synergism between interleukin (IL)-12 and IL-15 or IL-12 and IL-2 (1998) (28)
G Protein coupling of the rat A1-adenosine receptor—Partial purification of a protein which stabilizes the receptor-G protein association (1997) (27)
Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction (2015) (27)
[17] Purification of recombinant Gsα (1991) (27)
Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates (2017) (27)
Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers (2008) (26)
Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters. (2017) (26)
SLC6 Transporter Folding Diseases and Pharmacochaperoning. (2018) (26)
2',3'-Dialdehyde GTP as an irreversible G protein antagonist. Disruption and reconstitution of G protein-mediated signal transduction in cells and cell membranes. (1994) (24)
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2☆ (2014) (24)
Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites. (2016) (24)
Platelet Serotonin Transporter Function Predicts Default-Mode Network Activity (2014) (23)
The C2 catalytic domain of adenylyl cyclase contains the second metal ion (Mn2+) binding site. (1998) (23)
Selective serotonin reuptake inhibitors—A new modality for the treatment of lymphoma/leukaemia? (2007) (23)
JunB is a gatekeeper for B-lymphoid leukemia (2007) (23)
Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. (2001) (22)
Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A. (1992) (22)
Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer (2016) (22)
Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII (2015) (22)
A Two-state Model for the Diffusion of the A2A Adenosine Receptor in Hippocampal Neurons (2014) (22)
Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome (2019) (22)
A Tail of Two Signals: The C Terminus of the A2A-Adenosine Receptor Recruits Alternative Signaling Pathways (2006) (22)
Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism* (2017) (21)
Kinetic Models of Secondary Active Transporters (2019) (21)
Activation and inhibition of G proteins by lipoamines. (2002) (20)
Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane. (2014) (20)
A Combined Approach Using Transporter-Flux Assays and Mass Spectrometry to Examine Psychostimulant Street Drugs of Unknown Content (2012) (20)
Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site (2015) (20)
Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits (2020) (20)
Reoperation as treatment of relapse after subtotal thyroidectomy in Graves' disease. (1999) (20)
Functional Selectivity and Partial Efficacy at the Monoamine Transporters: A Unified Model of Allosteric Modulation and Amphetamine-Induced Substrate Release (2019) (20)
Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions (2016) (19)
Effects of duramycin on cardiac voltage-gated ion channels (2008) (19)
Cholera Toxin Induces Cyclic AMP‐Independent Down‐Regulation of Gsα and Sensitization of α2‐Autoreceptors in Chick Sympathetic Neurons (1996) (19)
Metal-dependent nucleotide binding to the Escherichia coli rotamase SlyD. (1999) (19)
Thyroid surgery in untreated severe hyperthyroidism: perioperative kinetics of free thyroid hormones in the glandular venous effluent and peripheral blood. (1994) (18)
A kinetic account for amphetamine-induced monoamine release (2018) (18)
How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers (2019) (18)
para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter (2019) (17)
Chaperoning of the A1-Adenosine Receptor by Endogenous Adenosine—An Extension of the Retaliatory Metabolite Concept (2015) (17)
Stimulation of adenylate cyclase activity via A2-adenosine receptors in isolated tubules of the rabbit renal cortex. (1987) (16)
Can a surgeon predict the risk of postoperative hypoparathyroidism during thyroid surgery? A prospective study on self-assessment by experts. (2014) (16)
The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter* (2017) (16)
The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins. (2006) (15)
The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome (2020) (15)
Against all odds—the persistent popularity of homeopathy (2020) (15)
ER-bound steps in the biosynthesis of G protein-coupled receptors. (2012) (15)
Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum (2018) (15)
Adenosine receptors in the heart: controversy about signal transmission (1985) (15)
Interaction of the antihypertensive drug urapidil with cardiac beta-adrenoceptors in vitro. (1984) (14)
The Ubiquitin-Specific Protease Usp 4 Regulates the Cell Surface Level of the A 2 a Receptor (2006) (14)
Pharmacological correction of misfolding of ABC proteins☆ (2014) (14)
A label-free approach to detect ligand binding to cell surface proteins in real time (2018) (14)
Late‐onset palsy of the recurrent laryngeal nerve after thyroid surgery (2014) (14)
Alterations of the Glomerular β-Adrenoceptor-Linked Adenylate Cyclase System in Perinephritis Hypertension (1986) (14)
Selective serotonin reuptake inhibitors: a new modality for the treatment of lymphoma/leukaemia? (2007) (14)
Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction (2019) (14)
The Environment Shapes the Inner Vestibule of LeuT (2016) (14)
Glomeruli and microvessels of the rabbit kidney contain both A1- and A2-adenosine receptors (1987) (13)
G protein-dependent signalling and ageing☆ (2000) (13)
A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities (2014) (13)
Calmodulin dependence of presynaptic metabotropic glutamate receptor signalling (1999) (12)
An unfolding story: Small molecules remedy misfolded monoamine transporters. (2017) (12)
Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function (2021) (11)
A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2 (2019) (11)
Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells (2016) (11)
When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters (2016) (10)
Adenosine-receptor-mediated stimulation of low-Km GTPase in guinea-pig cerebral cortex. (1985) (10)
Structural and functional characterization of the interaction between 2',3'-dialdehyde guanine nucleotide analogues and the stimulatory G protein alpha-subunit. (1994) (10)
Heterotrimeric G Protein-independent Signaling of a G Protein-coupled Receptor DIRECT BINDING OF ARNO/CYTOHESIN-2 TO THE CARBOXYL TERMINUS OF THE A2A ADENOSINE RECEPTOR IS NECESSARY FOR SUSTAINED ACTIVATION OF THE ERK/MAP KINASE PATHWAY* (2005) (10)
Reengineering the Collision Coupling and Diffusion Mode of the A2A-adenosine Receptor (2012) (10)
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism (2021) (9)
Neuromonitoring of the Recurrent Nerve: Validation and Merits (2003) (9)
Cardiac sarcolemmal purity is essential for the verification of adenylate cyclase inhibition via A1-adenosine receptors (1986) (9)
Functional impact of the G279S substitution in the adenosine A1-receptor (A1R-G279S), a mutation associated with Parkinson's disease. (2020) (9)
Protocol of a prospective study for parathyroid function monitoring during and after thyroidectomy (2006) (9)
Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation (2017) (8)
Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters (2020) (8)
The fallacy of non-selectivity of radioactive ligands (1988) (8)
Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans (2021) (8)
Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding (2021) (8)
Commentary on H. Ide et al., "Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells". (2008) (8)
Adenosine receptors mediate a pertussis toxin-insensitive prejunctional inhibition of noradrenaline release on a papillary muscle model (1991) (7)
Binding and structure‐activity‐relation of benzo[f]isoquinoline‐ and norcodeinone‐derivatives at μ‐opioid receptors in the rat cerebral cortex (1993) (7)
Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation (2016) (6)
Author Summary (6)
Effects of type I-interferons on human thyroid epithelial cells derived from normal and tumour tissue (1994) (6)
Development of Gs-selective inhibitory compounds. (2002) (6)
Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling (2021) (6)
Descriptors of Secondary Active Transporter Function and How They Relate to Partial Reactions in the Transport Cycle (2021) (6)
A Quantitative Model of Amphetamine Action on the Serotonin Transporter (2014) (6)
Reconstructive surgery after hemilaryngectomy for recurrent thyroid cancer using a free jejunal patch-graft. (1994) (6)
Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters (2017) (5)
Binding of [3H]ouabain to endothelial cells derived from various vascular beds (1987) (5)
The conservative view: is it necessary to implant a stent into the dopamine transporter? (2015) (5)
Perioperative kinetics of parathyroid hormone in unilateral, primary thyroid surgery (2015) (5)
Development of Refined Homology Models: Adding the Missing Information to the Medically Relevant Neurotransmitter Transporters (2014) (4)
Signal interception-based therapies – A double-edged sword in Bcr/abl-induced malignancies? (2008) (4)
Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy (2020) (4)
Pharmacological stimulation of murine and human hematopoetic stem cells (2012) (4)
Binding and neutralization of C. difficile toxins A and B by purified clinoptilolite-tuff (2021) (4)
Folding correction of ABC‐transporter ABCB1 by pharmacological chaperones: a mechanistic concept (2017) (4)
Differential Uncoupling of A 1 Adenosine and D 2 Dopamine Receptors by Suramin and Didemethylated Suramin ( NF 037 ) (1998) (4)
Lunar phase does not influence the incidence of postoperative haemorrhage after thyroid surgery: an analysis of 26,852 operations (2010) (4)
Coupling cofactor--a novel regulatory component in G protein-mediated signalling? (1997) (4)
Cellular signaling by an agonist-activated receptor/Gsa fusion protein (4)
Topically administered purified clinoptilolite‐tuff for the treatment of cutaneous wounds: A prospective, randomised phase I clinical trial (2022) (4)
Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability (2021) (4)
An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time (2019) (3)
Cooperativity between individual transporter protomers: new data fuelling old complexes (2015) (3)
Optimizing the Substrate Uptake Rate of Solute Carriers (2022) (3)
Biosimilars versus generics: scientific basics and clinical implications (2013) (3)
Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition (2017) (3)
Two saturable recognition sites for (-) [125I]iodo-N6-(4-hydroxyphenyl-isopropyl)-adenosine binding on purified cardiac sarcolemma. (1986) (2)
Receptor G protein coupling and the cytoskeleton (2007) (2)
Peptidomics screening for the discovery of uterotonic plant peptides (2012) (2)
Covalent modification of G-proteins by affinity labeling. (2004) (2)
Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics (2019) (2)
Purification of recombinant Gs alpha. (1991) (2)
Functional Impact of the G 279 S Substitution in the Adenosine A 1-Receptor ( A 1 RG 279 S 7 . 44 ) , a Mutation Associated with Parkinson ’ s Disease (2020) (2)
Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome (2018) (2)
A tropane-based ibogaine analog rescues folding-deficient SERT and DAT (2020) (2)
Abstract A181: Oxidized macrophage migration inhibitory factor (oxMIF) is a previously unrecognized, disease-related isoform of MIF and a potential new drug target in cancer. (2013) (2)
Functional Impact of the G279S Substitution in the Adenosine A1-Receptor (A1R-G279S7.44), a Mutation Associated with Parkinson’s Disease (2020) (2)
Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour (2015) (2)
Tracer Flux Measurements to Study Outward Transport by Monoamine Neurotransmitter Transporters (2016) (2)
811: Fully human antibodies specific for oxidized macrophage migration inhibitory factor (oxMIF) exhibit anti-cancer activity in animal models (2014) (2)
ARNO / CYTOHESIN-2 TO THE CARBOXYL TERMINUS OF THE A 2 A-ADENOSINE RECEPTOR IS NECESSARY FOR SUSTAINED ACTIVATION OF THE ERK / MAP-KINASE PATHWAY * (2005) (2)
Unifying Concept of Serotonin Transporter-associated (2012) (1)
Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor (2010) (1)
Regimen-dependent synergism and antagonism of treprostinil and vildagliptin in hematopoietic cell transplantation (2019) (1)
Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters (2012) (1)
Monoamine Transporters in the Brain (2007) (1)
Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosph (2019) (1)
Effect of rain on absorption after transdermal application of flunixin in calves (2019) (1)
Calmodulin kinase II regulates amphetamine-induced reverse transport in the dopamine transporter: implications for the importance of the dopamine transporter in Angelman syndrome (2010) (1)
Rescue of Misfolded Organic Cation Transporter 3 Variants (2022) (1)
Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor (2021) (1)
Pharmacological stimulation of murine and human hematopoetic stem cells (2012) (1)
Selective serotonin reuptake inhibitors induce cell death via the unfolded protein response (2008) (1)
A mechanism of uncompetitive inhibition of the serotonin transporter (2022) (1)
IS THE LATCH FOR TRIGGERED ACTIVATION OF HETEROTRIMERIC G PROTEINS (2005) (1)
17 Monoamine Transporters in the Brain: Structure and Function (2007) (1)
How does the carboxyl terminus assist folding and ER export of the serotonin transporter? (2012) (1)
The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin tranporter. (2010) (1)
Antibakterielle Chemotherapie (2020) (1)
Constitutive Endocytosis of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter-3 Requires ARFGAP1 (2021) (1)
Stimulation of p70S6 kinase phosphorylation by the A2A adenosine receptor in primary human endothelial cells and in CHO cells heterologously expressing the receptor (1998) (1)
Bioequivalence between two furosemide-spironolactone formulations: a pharmacokinetic and pharmacodynamic approach. (1991) (1)
Towards an understanding of the psychostimulant action of amphetamine and cocaine (2012) (1)
Assessing the Accuracy of Sales Forecasts Submitted by Pharmaceutical Companies Applying for Reimbursement in Austria (2021) (1)
Abstract 4841: Oxidized macrophage migration inhibitory factor (oxMIF) expressed by tumor stroma and tumor cells, contributes to tumor growth (2014) (1)
Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter (2018) (1)
Oligomerization of the GABA transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II * (2004) (1)
Animal Models for Depression and the Mode of Action of Neurotransmitter Transporter-Blocking Antidepressants (2016) (1)
Covalent modification of G proteins by affinity labeling. (1997) (1)
(+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. (2022) (1)
Peptide-based interactions with calnexin target misassembled GABA transporter-1 molecules into organized smooth endoplasmic reticulum compartments* (2007) (1)
Adenosine Receptor Biology in the Central Nervous System (2017) (1)
Allosteric modulators of solute carrier function: a theoretical framework (2023) (0)
Interrogating the Role of Extracellular Loops 2 and 4 (EL2 and EL4) of the Serotonin Transporter with Antibody Fragments (2020) (0)
Chaperoning of the A 1-Adenosine Receptor by Endogenous Adenosine — An Extension of the Retaliatory Metabolite Concept s (2014) (0)
A Kinetic Assessment of Ligand Binding to Monoamine-Transporters (2015) (0)
The folding interactome of GPCRs (2011) (0)
Intrinsic Activity, 2014; 2(Suppl.1) (2014) (0)
Diminished reaction of PI3Kδ−/− CTLs to allogeneic mixed lymphocytes, but unaltered proliferation and Ca 2+ -response. (2012) (0)
Molecular Dopamine Transporter Efflux in ADHD (2008) (0)
Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter (2009) (0)
Enriched stable 204Pb as tracer at ultra-low levels in clinical investigations (2022) (0)
Unfolding the Structure of LeuT Employing Luminescence Resonance Energy Transfer (2014) (0)
Prostacyclin, analogue or derivative thereof for the treatment of cystic fibrosis (2010) (0)
Decrypting structural and functional changes in LeuTAa at atomic level employing LRET (2012) (0)
Determining the Rate of Unfolding and Refolding of FNIII Domains by Labeling Buried Cysteine (2014) (0)
[Role of G protein-mediated signal transduction in molecular pharmacodynamics]. (1990) (0)
Microsoft Word-47328733-file00 (2010) (0)
Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A (2011) (0)
Cocaine Adulterants and Effects on Monoamine Transporters (2017) (0)
Feature 1 Comparative Morbidity of Axillary Lymph Node Dissection and the Sentinel Lymph Node Technique : Implications for Patients With Breast Cancer (2004) (0)
Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters (2012) (0)
Restricted collision coupling of the adenosine A2A receptor is due to its agonist-induced confinement in the membrane (2012) (0)
Pharmacochaperoning of the ER-retained A1 adenosine receptor (2012) (0)
Receptor‐Mediated G Protein Activation: How, How Many, and Where? (2010) (0)
The Molecular Basis of the Interaction Between Drugs and Neurotransmitter Transporters (2017) (0)
ExpressionofGProtein-CoupledReceptor19inHumanLung CancerCellsIsTriggeredbyEntryintoS-PhaseandSupports G2-M Cell-Cycle Progression (2012) (0)
Two Distinct Ligand Binding Sites in Monoamine Transporters Monitored by Nanopharmacological Force Sensing (2020) (0)
Expression of GProtein-CoupledReceptor 19 inHumanLung CancerCells Is Triggered byEntry into S-Phase andSupports G2–M Cell-Cycle Progression (2012) (0)
Abstract 1235: Human antibodies specific for a novel isoform of the macrophage migration inhibitory factor are potential therapeutics for prostate cancer. (2013) (0)
Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism. (2017) (0)
Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1 (2022) (0)
H UMAN A NTI -M ACROPHAGE M IGRATION I NHIBITORY F ACTOR (MIF) A NTIBODIES I NHIBIT G ROWTH OF H UMAN P ROSTATE C ANCER C ELLS IN V ITRO AND IN V IVO (2013) (0)
Induced Fit Docking into a SERT Homology Model (2009) (0)
Adenylate cyclase-coupled adenosine receptors in the heart: A reevaluation (1985) (0)
An Ionic Lock Between Intracellular Loop 1 and a C‐terminal Amphipathic Helix Stabilizes the Serotonin Transporter Along its Folding Trajectory (2015) (0)
Gene Therapy for Infantile Parkinsonism (2019) (0)
The role of the carboxyl terminus in folding of the serotonin transporter (2010) (0)
PI3Kδ: a double-edged sword in leukemia formation (2007) (0)
Peptide GPCRs as molecular targets for plant cyclotides (2013) (0)
Restricted collision coupling of the adenosine A2Areceptor is due to its agonist-induced confinement in the membrane (2012) (0)
Functional Dynamics of Glutamate/Amino Acid Transporters of the Solute Carrier 1 Family (2015) (0)
Mutations in Gs alpha that alter the kinetics of guanine nucleotide binding and hydrolysis. (1991) (0)
LRET-based intramolecular distance measurements in LeuTAa (2011) (0)
Exploring Bioactive Peptides as Pharmacological Tools for Oxytocin and Vasopressin Ligand Design (2014) (0)
Regimen-dependent synergism and antagonism of treprostinil and vildagliptin in hematopoietic cell transplantation (2019) (0)
Austria should invest in brains, not in bricks, banks or airlines (2009) (0)
45th Annual Meeting of the Austrian Society of Surgery, Klagenfurt, June 10–12, 2004 (2004) (0)
Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome (2018) (0)
Reply to J. Gordon et al. (2008) (0)
Treprostinil stimulates the engraftment of haematopoetic stem cells (2011) (0)
Association Rate Constants as Determinants of Ligand Selectivity:Lessons from The Dopamine And The Serotonin Transporter (2015) (0)
Joint Meeting of the Austrian Neuroscience Association (13 ANA Meeting) and the Austrian Pharmacological Society (19 Scientific Symposium of APHAR) (2013) (0)
Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter (2009) (0)
SAP102, a novel interaction partner of the A2A adenosine receptor (2007) (0)
Tracking the A2A adenosine receptor (2010) (0)
Transporters in Motion: Combining Computational Approaches and LRET-Measurements (2015) (0)
Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters (2016) (0)
Peptidomics screening for the discovery of uterotonic plant peptides (2012) (0)
Safety and efficacy of purified clinoptilolite-tuff treatment in patients with irritable bowel syndrome with diarrhea: Randomized controlled trial (2022) (0)
Inhibition of signaling via erbB-receptors by antibodies that target the Lewis Y-antigen (2004) (0)
Cyclotides as templates for peptide GPCR ligand design - discovery of the target receptor of the oxytocic plant peptide kalata B7 (2013) (0)
Abstract 2654: Human antibodies specific for oxidized macrophage migration inhibitory factor (oxMIF) synergize with chemotherapeutic agents in animal models of cancer (2014) (0)
Beyond G proteins: The role of accessory proteins in G protein-coupled receptor signalling (2002) (0)
Prostacyclin analogue composition and method for enhancing engraftment of haematopoetic stem cells (2012) (0)
Duramycin effects on voltage-gated ion channels: a QT-prolongation risk? (2007) (0)
The N-terminus acts as a lever to support amphetamine-induced substrate efflux by the serotonin transporter (2012) (0)
Regulation of CFTR expression and function by NOS isoforms (2009) (0)
Decrypting structural and functional changes in LeuTAaat atomic level employing LRET (2012) (0)
Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism (2010) (0)
P.2.b.025 Serotonin uptake in blood platelets is related to cingulate cortex activation (2010) (0)
Voltage dependence of monoamine transporter function is determined by handling of intracellular potassium (2022) (0)
818: Human antibodies specific for oxidized macrophage migration inhibitory factor (oxMIF) synergize with chemotherapeutic agents in animal models of cancer (2014) (0)
cell-mediated tumor surveillance Leukemic challenge unmasks a requirement for PI3K{delta} in NK (2009) (0)
Novel sources for potent and selective GPCR modulators (2012) (0)
The mitotic checkpoint protein MAD2 delivers monoamine transporters to endocytosis (2021) (0)
PI3Kδ is indispensable for CTL-mediated cytotoxicity (2011) (0)
Pharmacological characterization of circular plant peptides with oxytocin-like activity (2012) (0)
Genetic Regulation of Emotion Brain Circuitries (2011) (0)
Solving the trade-off by differences in handling of intracellular K+: why substrate translocation by the dopamine transporter but not by the serotonin transporter is voltage-dependent (2020) (0)
Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C (2010) (0)
Investigating EAAT3 trafficking through the secretory pathway (2015) (0)
Dissecting the Catalytic Cycle of the Serotonin Transporter (2016) (0)
Deciphering the Nature of M1R Transient Currents (2020) (0)
How does the carboxyl terminus assist folding and ER export of the serotonin transporter? (2012) (0)
Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters (2012) (0)
Truncations in the amino terminus reveal a region key to supporting amphetamine-induced efflux by the human serotonin transporter (2011) (0)
1 HUMAN ANTI-MACROPHAGE MIGRATION INHIBITORY FACTOR ( MIF ) ANTIBODIES INHIBIT GROWTH OF HUMAN PROSTATE CANCER CELLS IN VITRO AND IN VIVO (2013) (0)
Circular plant peptides as templates for GPCR drug discovery? (2011) (0)
4‐Phenylbutyrate rescues folding‐deficient creatine transporter‐1 variants linked to the creatine transporter deficiency syndrome (2019) (0)
Corrigendum to "Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits" [Pharmacology & Therapeutics 222 (2021) 107785]. (2021) (0)
Luminescence resonance energy transfer-based intramolecular distance measurements in leucine transporter from Aquifex aeolicus (2010) (0)
Pharmacochaperoning of the ER-retained A1adenosine receptor (2012) (0)
Stimulation ofhumanumbilical veinendothelial cell proliferation byA2-adenosine and132-adrenoceptor s (1995) (0)
The N-terminus acts as a lever to support amphetamine-induced substrate efflux by the serotonin transporter (2012) (0)
Large Molecule Therapeutics Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo (2013) (0)
12th Symposium of the Austrian Pharmacological Society (APHAR) (2006) (0)
Regulated Rapid Round Trips: Endocytotic Cycling of the Dopamine Transporter Shapes Motor Learning. (2023) (0)
Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters (2012) (0)

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