Michael A. Geeves
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Biology
Michael A. Geeves's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Molecular Biology Stanford University
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(Suggest an Edit or Addition)Michael A. Geeves's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. (1993) (765)
- Structural mechanism of muscle contraction. (1999) (736)
- The molecular mechanism of muscle contraction. (2005) (359)
- Toxoplasma gondii myosin A and its light chain: a fast, single‐headed, plus‐end‐directed motor (2002) (244)
- Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. (2000) (243)
- Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit. (1994) (192)
- The use of actin labelled with N-(1-pyrenyl)iodoacetamide to study the interaction of actin with myosin subfragments and troponin/tropomyosin. (1985) (191)
- The muscle thin filament as a classical cooperative/allosteric regulatory system. (1998) (191)
- The structural basis of muscle contraction. (2000) (182)
- Cooperativity and switching within the three-state model of muscle regulation. (1999) (172)
- Adenosine diphosphate and strain sensitivity in myosin motors. (2004) (172)
- The dynamics of actin and myosin association and the crossbridge model of muscle contraction. (1991) (170)
- Interaction of actin and ADP with the head domain of smooth muscle myosin: implications for strain-dependent ADP release in smooth muscle. (1998) (166)
- Modulation of actin affinity and actomyosin adenosine triphosphatase by charge changes in the myosin motor domain. (1998) (166)
- Cryptococcus neoformans Senses CO2 through the Carbonic Anhydrase Can2 and the Adenylyl Cyclase Cac1 (2006) (158)
- A systematic nomenclature for mammalian tropomyosin isoforms (2014) (151)
- The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. (2004) (150)
- Myosin motors with artificial lever arms. (1996) (145)
- Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue. (2001) (126)
- What limits the velocity of fast-skeletal muscle contraction in mammals? (2006) (124)
- Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: characterization of two acto-S1-ADP complexes. (1991) (122)
- Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation. (1995) (117)
- Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli (2010) (112)
- Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses (2018) (105)
- Molecular mechanism of actomyosin-based motility (2005) (103)
- Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor. (2011) (101)
- Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle Fibers* (2001) (99)
- Strain-dependent cross-bridge cycle for muscle. (1995) (98)
- Tension responses to rapid pressure release in glycerinated rabbit muscle fibers. (1991) (96)
- Myo1c is designed for the adaptation response in the inner ear (2004) (92)
- Kinetic characterization of a cytoplasmic myosin motor domain expressed in Dictyostelium discoideum. (1993) (91)
- What kinesin does at roadblocks: the coordination mechanism for molecular walking (2004) (89)
- Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function (2015) (89)
- Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium. (2003) (89)
- Kinetics of fast enzyme reactions: Theory and practice (1980) (89)
- Transient Kinetic Analysis of the 130-kDa Myosin I (MYR-1 Gene Product) from Rat Liver (1999) (88)
- Actin-tropomyosin activation of myosin subfragment 1 ATPase and thin filament cooperativity. The role of tropomyosin flexibility and end-to-end interactions. (1997) (87)
- Diffusional barrier crossing in a two-state protein folding reaction (1999) (87)
- Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin. (2004) (84)
- Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe (2007) (80)
- Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin. (1999) (79)
- Pressure-relaxation studies of pyrene-labelled actin and myosin subfragment 1 from rabbit skeletal muscle. Evidence for two states of acto-subfragment 1. (1985) (74)
- Towards a Unified Theory of Muscle Contraction. I: Foundations (2008) (74)
- Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle (1984) (74)
- KIF1D is a fast non‐processive kinesin that demonstrates novel K‐loop‐dependent mechanochemistry (2001) (71)
- Identification of functional differences between recombinant human α and β cardiac myosin motors (2012) (71)
- Dictyostelium discoideum myosin II: characterization of functional myosin motor fragments. (1997) (71)
- The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres (1994) (69)
- The limiting rate of the ATP‐mediated dissociation of actin from rabbit skeletal muscle myosin subfragment 1 (1983) (69)
- Kinetic Analyses of a Truncated Mammalian Myosin I Suggest a Novel Isomerization Event Preceding Nucleotide Binding* (2000) (69)
- Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems. (2003) (68)
- Characterization of the equilibrium between blocked and closed states of muscle thin filaments. (1995) (65)
- The role of three-state docking of myosin S1 with actin in force generation. (1995) (64)
- Molecular motors: Stretching the lever-arm theory (2002) (63)
- Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear (2008) (62)
- Microsecond folding of the cold shock protein measured by a pressure-jump technique. (1999) (60)
- Actin Residue Glu93 Is Identified as an Amino Acid Affecting Myosin Binding* (1999) (58)
- Cooperativity between the two heads of rabbit skeletal muscle heavy meromyosin in binding to actin. (1998) (57)
- An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis (2012) (56)
- Kinetic analysis of Dictyostelium discoideum myosin motor domains with glycine-to-alanine mutations in the reactive thiol region. (1999) (55)
- Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins : Transient kinetic analysis of S1 isoforms (1998) (55)
- Review: The ATPase mechanism of myosin and actomyosin (2016) (55)
- Looking at long molecules in solution: what happens when they are subjected to Couette flow? (2006) (55)
- Changes in Mg2+ Ion Concentration and Heavy Chain Phosphorylation Regulate the Motor Activity of a Class I Myosin* (2005) (54)
- Actomyosin regulatory properties of yeast tropomyosin are dependent upon N-terminal modification. (2000) (54)
- The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy. (2012) (54)
- The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin* (2013) (53)
- Reversible movement of switch 1 loop of myosin determines actin interaction (2007) (53)
- Mutations in the relay loop region result in dominant‐negative inhibition of myosin II function in Dictyostelium (2002) (52)
- A novel stopped-flow method for measuring the affinity of actin for myosin head fragments using μg quantities of protein (1996) (52)
- Dynamic interaction between actin and myosin subfragment 1 in the presence of ADP. (1989) (51)
- Dilated cardiomyopathy myosin mutants have reduced force-generating capacity (2018) (48)
- Regulation of the acto.myosin subfragment 1 interaction by troponin/tropomyosin. Evidence for control of a specific isomerization between two acto.myosin subfragment 1 states. (1991) (48)
- Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis (2006) (48)
- Kinetic Mechanism of Myosin IXB and the Contributions of Two Class IX-specific Regions* (2005) (47)
- Three-dimensional stochastic model of actin–myosin binding in the sarcomere lattice (2016) (47)
- Upregulation of Cardiomyocyte Ribonucleotide Reductase Increases Intracellular 2 deoxy-ATP, Contractility, and Relaxation (2011) (47)
- The Slow Skeletal Muscle Isoform of Myosin Shows Kinetic Features Common to Smooth and Non-muscle Myosins* (2006) (45)
- Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins. Transient kinetic analysis of S1 isoforms. (1998) (45)
- Using Fluorescent Myosin to Directly Visualize Cooperative Activation of Thin Filaments*♦ (2014) (45)
- Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments (2007) (44)
- Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin* (2009) (44)
- The effect of nucleotide upon a specific isomerization of actomyosin subfragment 1. (1988) (44)
- Myosin isoforms and the mechanochemical cross-bridge cycle (2016) (43)
- Substrate Specificity of Human Nucleoside-diphosphate Kinase Revealed by Transient Kinetic Analysis* (1998) (43)
- Two-step ligand binding and cooperativity. A model to describe the cooperative binding of myosin subfragment 1 to regulated actin. (1987) (42)
- A Modulatory Role for the Troponin T Tail Domain in Thin Filament Regulation* (2002) (42)
- Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms. (2017) (41)
- Differential Regulation of the Actomyosin Interaction by Skeletal and Cardiac Troponin Isoforms* (2003) (40)
- α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains (2012) (40)
- Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence. (2001) (39)
- Cryoenzymology: the study of enzyme catalysis at subzero temperatures. (1979) (39)
- Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations (2019) (37)
- ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomerization of the ternary acto-S1-ATP complex. (1986) (35)
- Kinetic Analysis of the Slow Skeletal Myosin MHC-1 Isoform from Bovine Masseter Muscle (2007) (35)
- Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm–Tn chain (2012) (35)
- Bisphosphorylation of cardiac troponin I modulates the Ca2+‐dependent binding of myosin subfragment S1 to reconstituted thin filaments (1996) (35)
- Kinetic Analysis of Drosophila Muscle Myosin Isoforms Suggests a Novel Mode of Mechanochemical Coupling* (2003) (35)
- A novel pressure-jump apparatus for the microvolume analysis of protein-ligand and protein-protein interactions: its application to nucleotide binding to skeletal-muscle and smooth-muscle myosin subfragment-1. (2002) (34)
- Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin. (1995) (34)
- Cooperative [Ca²+]-dependent regulation of the rate of myosin binding to actin: solution data and the tropomyosin chain model. (2011) (34)
- Hydrostatic compression in glycerinated rabbit muscle fibers. (1990) (33)
- Protein fluorescence changes associated with ATP and adenosine 5'-[gamma-thio]triphosphate binding to skeletal muscle myosin subfragment 1 and actomyosin subfragment 1. (1988) (33)
- Stabilization of the actomyosin complex by negative charges on myosin. (2000) (33)
- Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors (2012) (33)
- The Superfast Human Extraocular Myosin Is Kinetically Distinct from the Fast Skeletal IIa, IIb, and IId Isoforms* (2013) (32)
- MyBP-C: one protein to govern them all (2020) (32)
- Contractile activation and force generation in skinned rabbit muscle fibres: effects of hydrostatic pressure. (1994) (32)
- The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects* (2016) (32)
- Loop 1 of Transducer Region in Mammalian Class I Myosin, Myo1b, Modulates Actin Affinity, ATPase Activity, and Nucleotide Access* (2005) (32)
- The use of pressure perturbations to investigate the interaction of rabbit muscle myosin subfragment 1 with actin in the presence of MgADP (1982) (32)
- A nucleation–elongation mechanism for the self‐assembly of side polar sheets of smooth muscle myosin. (1991) (31)
- A novel stopped-flow method for measuring the affinity of actin for myosin head fragments using microgram quantities of protein. (1996) (31)
- Thermal unfolding of smooth muscle and nonmuscle tropomyosin α‐homodimers with alternatively spliced exons (2006) (31)
- Actomyosin kinetics and in vitro motility of wild-type Drosophila actin and the effects of two mutations in the Act88F gene. (1995) (31)
- Kinetic characterization of myosin head fragments with long-lived myosin.ATP states. (1998) (30)
- High-speed imaging of glutamate release with genetically encoded sensors (2019) (30)
- The myosin-activated thin filament regulatory state, M−-open: a link to hypertrophic cardiomyopathy (HCM) (2014) (30)
- Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain. (2015) (30)
- Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. (2020) (30)
- Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function. (2000) (29)
- Functional homodimers and heterodimers of recombinant smooth muscle tropomyosin. (2006) (29)
- A kinetic model of the co-operative binding of calcium and ADP to scallop (Argopecten irradians) heavy meromyosin. (2002) (29)
- In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers. (2012) (29)
- Inhibition of actin-myosin subfragment 1 ATPase activity by troponin I and IC: relationship to the thin filament states of muscle. (2000) (29)
- Tropomyosin and troponin cooperativity on the thin filament. (2007) (29)
- Strain-dependent cross-bridge cycle for muscle. II. Steady-state behavior. (1995) (28)
- Kinetic and Mechanistic Basis of the Nonprocessive Kinesin-3 Motor NcKin3* (2006) (27)
- Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity (2019) (27)
- Polymorphism in tropomyosin structure and function (2013) (27)
- Changes produced by increased hydrostatic pressure in isometric contractions of rat fast muscle. (1991) (26)
- A flash photolysis fluorescence/light scattering apparatus for use with sub microgram quantities of muscle proteins (2004) (25)
- ADP Binding Induces an Asymmetry between the Heads of Unphosphorylated Myosin* (2001) (24)
- A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites. (2007) (23)
- Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties (2019) (23)
- Selective Perturbation of the Myosin Recovery Stroke by Point Mutations at the Base of the Lever Arm Affects ATP Hydrolysis and Phosphate Release* (2007) (23)
- Mechanism, Regulation, and Functional Properties of Dictyostelium Myosin-1B* (2008) (22)
- The dynamics of the interaction between myosin subfragment 1 and pyrene-labelled thin filaments, from rabbit skeletal muscle (1986) (21)
- Functional and biophysical analyses of the class XIV Toxoplasma gondii Myosin D (2006) (21)
- Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin (2019) (21)
- Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin. (2008) (21)
- Cooperativity in the Ca2+ regulation of muscle contraction. (2002) (20)
- The actomyosin ATPase: a two-state system. (1992) (20)
- Molecular Mechanisms in Muscular Contraction (1990) (20)
- Changes in catalytic activity and association state of pyruvate carboxylase which are dependent on enzyme concentration. (2002) (20)
- Dynamics of Tropomyosin in Muscle Fibers as Monitored by Saturation Transfer EPR of Bi-Functional Probe (2011) (20)
- Human Nucleoside Diphosphate Kinase B (Nm23-H2) from Melanoma Cells Shows Altered Phosphoryl Transfer Activity Due to the S122P Mutation* (1999) (19)
- Modeling thin filament cooperativity. (2002) (19)
- Isolation and kinetic characterisation of myosin and myosin S1 from the Drosophila indirect flight muscles (2004) (19)
- Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres (1987) (19)
- Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V* (2011) (18)
- The regulation of myosin binding to actin filaments by Lethocerus troponin. (2007) (18)
- Characterization of the cardiac holotroponin complex reconstituted from native cardiac troponin T and recombinant I and C. (1999) (18)
- Resolution and uniqueness of estimated parameters of a model of thin filament regulation in solution (2010) (18)
- Kinetics of an enzyme-catalyzed reaction measured by electrospray ionization mass spectrometry using a simple rapid mixing attachment. (2004) (18)
- Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin (2010) (18)
- Protein-bound adenosine 5'-triphosphate: properties of a key intermediate of the magnesium-dependent subfragment 1 adenosinetriphosphatase from rabbit skeletal muscle. (1982) (16)
- Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head. (2009) (16)
- Ionic interactions play a role in the regulatory mechanism of scallop heavy meromyosin. (2003) (16)
- Rapid folding of the prion protein captured by pressure-jump (2009) (15)
- Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II. (1998) (15)
- Pressure sensitivity of active tension in glycerinated rabbit psoas muscle fibres: Effects of ADP and phosphate (1989) (15)
- Interactions of the two heads of scallop (Argopecten irradians) heavy meromyosin with actin: influence of calcium and nucleotides. (2003) (14)
- Multiscale modeling of twitch contractions in cardiac trabeculae (2021) (14)
- Tropomyosin Exon 6b Is Troponin-specific and Required for Correct Acto-myosin Regulation* (2004) (14)
- Force generation upon hydrostatic pressure release in tetanized intact frog muscle fibres (1999) (14)
- Alpha and beta myosin isoforms and human atrial and ventricular contraction (2021) (14)
- Production of amino-terminally acetylated recombinant proteins in E. coli. (2013) (14)
- The Hill model for binding myosin S1 to regulated actin is not equivalent to the McKillop-Geeves model. (2012) (14)
- Actomyosin kinetics of pure fast and slow rat myosin isoforms studied by in vitro motility assay approach (2012) (13)
- The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II* (2015) (13)
- Temperature manifold for a stopped-flow machine to allow measurements from -10 to +40°C. (2015) (12)
- Mechanism of adenosine 5'-triphosphate cleavage by myosin: studies with oxygen-18-labeled adenosine 5'-triphosphate. (1980) (12)
- Ultra Short Yeast Tropomyosins Show Novel Myosin Regulation* (2008) (12)
- 4.13 Thin Filament Regulation (2012) (12)
- Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities* (2011) (12)
- Overexpression of human cardiac troponin in Escherichia coli: its purification and characterization. (2001) (11)
- Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle (2022) (11)
- Effects of pressure on equatorial x-ray fiber diffraction from skeletal muscle fibers. (1993) (11)
- Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue (2017) (11)
- The kinetic mechanism of the release of nucleotide from elongation factor Tu promoted by elongation factor Ts determined by pressure relaxation studies. (1988) (11)
- Pressure-induced changes in the isometric contractions of single intact frog muscle fibres at low temperatures (1995) (11)
- The mechanism of thin filament regulation: Models in conflict? (2019) (10)
- The ATPase cycle of human muscle myosin II isoforms: Adaptation of a single mechanochemical cycle for different physiological roles (2019) (10)
- Kinetics of nucleotide binding to pyruvate carboxylase. (1995) (10)
- Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W. (2008) (9)
- Analysis of biophysical and functional consequences of tropomyosin–fluorescent protein fusions (2016) (9)
- The Binding and Cleavage of ATP in the Myosin and Actomyosin ATPase Mechanisms (1976) (9)
- Use of pyrene-labelled actin to probe actin-myosin interactions: kinetic and equilibrium studies. (2014) (9)
- Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin (2004) (9)
- The influence of anions, ionic strength and organic solvents on the interaction between actin and myosin subfragment 1. (1990) (8)
- The influence of pressure on actin and myosin interactions in solution and in single muscle fibres (1991) (8)
- Effects of hydrostatic pressure on fatiguing frog muscle fibres (1996) (8)
- The effect of hydrostatic pressure on the interaction of actomyosin subfragment 1 with nucleotides. (1991) (7)
- A "slow" temperature jump apparatus built from a stopped-flow machine. (1991) (7)
- The effect of cryosolvents on the spectral and catalytic properties of liver alcohol dehydrogenase. (1983) (6)
- The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions. (2021) (6)
- Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. (2010) (6)
- Cooperativity in the Ca2+-Regulation of Skeletal Muscle Contraction (2002) (5)
- crossbridge model of muscle contraction (2005) (5)
- Rapid reaction kinetic techniques. (2014) (5)
- 2-deoxy-ATP Alters Myosin Structure to Enhance Cross-Bridge Cycling and Improve Cardiac Function (2013) (5)
- FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) (2014) (5)
- Identification of sequence changes in myosin II that adjust muscle contraction velocity (2021) (5)
- Effect of phosphate and sulphate on the interaction of actin and myosin subfragment 1. (1990) (5)
- Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer (2017) (4)
- Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans (2022) (4)
- Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence (2019) (4)
- Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency. (2019) (4)
- Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments (2019) (4)
- Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain (2020) (3)
- Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles (2022) (3)
- Kinetic and mechanistic basis of the non-processive Kinesin-3 motor NcKin 3 (2006) (3)
- Ultrafast glutamate sensors resolve synaptic short-term plasticity (2017) (3)
- Drug Effects and Mechanism Underlying the Force-velocity Relationship of Skeletal Muscle (2009) (3)
- Modification Of Loop 1 Affects The Nucleotide-Binding Properties Of Myo1c, The Adaptation Motor In The Inner Ear (2009) (3)
- Activation and Relaxation Kinetics in Skeletal and Cardiac Muscles (2015) (3)
- Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors (2012) (3)
- Thin Filament Regulation of Relaxation in 3D Multi-Sarcomere Geometry (2009) (3)
- Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP. (2020) (3)
- TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium (2019) (3)
- Dynamic Transient Responses of Muscle Fibers with a Heterogeneous Populations of Isoforms and Mutation (2016) (2)
- A novel live-cell imaging system reveals a reversible hydrostatic pressure impact on cell-cycle progression (2018) (2)
- Effect of N-terminal mutations on the properties of yeast tropomyosin 1 (1998) (2)
- Modulation of Crossbridge Cycling Kinetics and Length Dependent Calcium Sensitivity by Titin and Nebulin (2013) (2)
- Mg2+‐free ATP regulates the processivity of native cytoplasmic dynein (2019) (2)
- The use of fast kinetic systems for the study of ng-mu g quantities of purified muscle proteins (1998) (2)
- Review Molecular mechanism of actomyosin-based motility (2005) (2)
- Erratum: Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue (Biochemistry (October 2001) 40:42 (12727-12737)) (2004) (2)
- Erratum: Kinetic mechanism of myosin IXB and the contributions of two class lX-specific regions (Journal of Biological Chemistry (2005) 280, (38957-38968)) (2006) (2)
- Cross-talk, cross-bridges, and calcium activation of cardiac contraction. (2014) (2)
- A cell for X‐ray diffraction in liquids under moderate hydrostatic pressure (1989) (2)
- Effect of Myosin Isoform on Mechanics in Intact Cardiac Trabeculae from Mice, Rats and Humans (2020) (2)
- Functional Analysis of Freeman-Sheldon Syndrome Causing Mutations on Embryonic Myosin (2015) (2)
- Direct measurement of myofilament calcium in living cardiomyocytes (2018) (2)
- Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy (2)
- Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae. (2008) (2)
- Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties (2019) (1)
- The use of fast kinetic systems for the study of ng-microgram quantities of purified muscle proteins. (1998) (1)
- Influence of cTn Ca 2+ Binding Properties and Cooperative Mechanisms on Cardiac Muscle Contractile Dynamics (2018) (1)
- Kinetic characterization of myosin head fragments with long-lived myosin center dot ATP states (1998) (1)
- Pressure jump studies of ADP release from smooth/skeletal muscle S1 (2002) (1)
- Transient kinetics of actomyosin using 100 ng of proteins (1999) (1)
- Measurement of myofilament calcium in living cardiomyocytes using a targeted genetically encoded indicator (2018) (1)
- Effect of Nonlinear Crossbridge Elasticity on Kinetics of Sarcomeric Contraction (2014) (1)
- Proteins: from chemical to physiological mechanism (2002) (1)
- Single Molecule Imaging Reveals the Mechanism Ofactin.Tn.Tm Activation and Deactivation (2017) (1)
- Modelling the Calcium Dependent Actin-Myosin ATP-ase Cycle in Solution (2015) (1)
- Structure-Function Investigation of the E258K-Mybpc3 Mutation in HCM Patient-Derived Cardiomyocytes (2021) (1)
- Kinetics: Relaxation Methods. (2013) (1)
- Kinetic characterisation of the myosin A from toxoplasma gondii (2000) (1)
- Herbert (Freddie) Gutfreund. 21 October 1921—21 March 2021 (2022) (1)
- A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins. (2019) (1)
- Molecular Assays for Acto-Myosin Interactions (2006) (1)
- Adaptation of mammalian myosin II sequences to body mass (2016) (1)
- Effects of TnT and TnT1 upon regulation of actin-tropomyosin (2000) (0)
- Crystal Structure of CobH (precorrin-8x methyl mutase) complexed with C5 desmethyl-HBA (2012) (0)
- Interactions of Calmodulin and the IQ Motifs of a Type I Myosin in Fission Yeast (2012) (0)
- Abstracts of the 11 th Electronic Computational Chemistry Conference – ECCC 11 (2008) (0)
- Mechanical and Biochemical Characteristics of Human Stem Cell-Derived Cardiomyocytes (2010) (0)
- Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils (2022) (0)
- Dynamics of Bi-Functional Labeled Tropomyosin in Muscle Ghost Fiber Monitored by Saturation Transfer EPR (2009) (0)
- SP451EFFECT OF ACIDOSIS ON MAXIMAL ISOMETRIC TENSION OF UREMIC PERMEABILIZED FIBRES (2015) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 359 (1452) (2004) (0)
- Kinetic dissection of the effect of negative charges of loop 2 on the enzymatic activity of myosin (2000) (0)
- Measurement of actin filament regulation using a myosin S1 titration at nanomolar actin concentrations (1998) (0)
- β-MYHC Mutations Linked to Early-Onset HCM and DCM Show Differences in Pre-Steady and Steady State Kinetic Parameters (2016) (0)
- Kinetics of Mouse Alpha-Myosin S1 a Fast Myosin (2011) (0)
- Transient kinetic studies of phosphate-transfer reactions in human-beta nucleoside diphosphate kinase. (1997) (0)
- Table of Contents (1996) (0)
- Kinetic dissection of the actin binding region of Dictyostelium myosin II (1998) (0)
- Changes in Myosin Crossbridge Cycle during Human Development (2017) (0)
- Contractile activation andforce generation inskinned rabbit muscle fibres: effects ofhydrostatic pressure (2011) (0)
- Kinetic Characterization of Converter and Relay Loop Domain Interaction in Drosophila Myosin Sub-Fragment 1 (2012) (0)
- chains in single muscle fibers Quantitative electrophoretic analysis of myosin heavy (2015) (0)
- The myosin-activated thin filament regulatory state, M−-open: a link to hypertrophic cardiomyopathy (HCM) (2014) (0)
- The effect of small molecule myosin modulators on ATP turnover in pig cardiac HMM using stopped flow spectroscopy. (2023) (0)
- Polymorphism in tropomyosin structure and function (2013) (0)
- A molecular scale investigation of the mechanisms of contractile dysfunction for the hypertrophic cardiomyopathy MYH7 G256E mutation. (2023) (0)
- The XXVIII European Muscle conference. York, UK, 4-7 September 1999. (1999) (0)
- Kinetic Analysis of Human a and Cardiac Myosin Motor Domains (2011) (0)
- The Hcm Mutation R453C in the Human Beta Myosin Motor Domain Alters the ATP-Binding and Hydrolysis Steps (2014) (0)
- High-speed imaging of glutamate release with genetically encoded sensors (2019) (0)
- Persistence Length of Tropomyosin Heterodimers Formed from Wild-Type and Mutant Chains (2013) (0)
- A Dictyostelium discoideum myosin head fragment expressed with the mutation E459V results in a stable myosin center dot ATP complex (1998) (0)
- Elucidating the mechanism of Danicamtiv on force, kinetics, and myosin structure and function. (2023) (0)
- ATPase Cycle Analysis Predicts that Mutations Linked to Dilated Cardiomyopathy in Human Beta Myosin Will Impair Force Generation (2018) (0)
- The Dynamics of Tropomyosin in Muscle Fibers (2009) (0)
- Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle (2023) (0)
- Effects of Phosphomimetic Mutations on the Persistence Length and Thin Filament Binding Properties of α and β-Tropomyosin (2014) (0)
- Modulators of actin-myosin dissociation : basis for muscle type differences in contraction during fatigue 104 characters incl (2017) (0)
- Lessons from the Actin-Myosin II Family; Docking, Mechanochemistry and Myopathies (2019) (0)
- Mutations in the relay loop region result in dominant‐negative inhibition of myosin II function in Dictyostelium (2002) (0)
- Pressure induced relaxation of mantADP binding to myosin S1 using a micro-volume pressure jump apparatus (1998) (0)
- Identification of functional differences between recombinant human α and β cardiac myosin motors (2012) (0)
- Temperature Dependence of MgATP and MgADP Affinity of Fast and Slow Rat Myosin Isoforms: An in Vitro Motility Assay Approach (2010) (0)
- Computational modeling of the effects of drugs in HCM and DCM cardiomyopathies (2022) (0)
- Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm–Tn chain (2012) (0)
- Table of Contents (1991) (0)
- Acetylation stabilises calmodulin‐regulated calcium signalling (2022) (0)
- Contributory presentations/posters (1999) (0)
- Effects of Hydrostatic-Pressure on Muscle Contraction: A Look Back on Some Experimental Findings (2023) (0)
- Modulation of Fast Transients by Compliance of Crossbridges and Myofilaments (2017) (0)
- Effect of Mutations in cMyBP-C on Sarcomere Mechanical Function (2015) (0)
- Mechano-Chemical Coupling in Sarcomere Lattice Modulated by Nonlinear Crossbridge Elasticity (2018) (0)
- Modeling the ATPase Cycle of Human Myosin II Isoforms and their Mutations (2017) (0)
- New and Notable Tuning the Calcium Sensitivity of Cardiac Muscle (2012) (0)
- Actin Sliding Velocities Are Influenced By The Chemical Driving Force Of Actin-myosin Binding (2009) (0)
- Crystal structure of the core FH2 domain of mouse mDia1 (2004) (0)
- Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes. (2023) (0)
- Tuning the calcium sensitivity of cardiac muscle. (2012) (0)
- Tuning Cardiomyocite Dynamic Transient Responses with a Heterogeneous Populations of cTnC Mutations (2017) (0)
- Decision letter: Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil (2020) (0)
- Regulating Native Cytoplasmic Dynein's Processivity (2017) (0)
- Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b (2023) (0)
- Studying the interacting head motif in fast, slow, and cardiac myofibrils in stopped-flow (2022) (0)
- Fluorescent Live Cell Imaging Under Pressure (2012) (0)
- EPR as a Tool to Study the Dynamic of Tropomyosin in the Muscle Fiber - Use of a Bifunctional Spin Label (2010) (0)
- Pseudo-phosphorylation of essential light chains affects the functioning of skeletal muscle myosin. (2022) (0)
- MyBP-C: one protein to govern them all (2020) (0)
- A systematic nomenclature for mammalian tropomyosin isoforms (2014) (0)
- Generation of a functional myosin motor by inversion of a salt bridge between the N2 and N3 motifs (1999) (0)
- More Can Mean Less, or: Simplifying Sometimes Requires Ideas to Be More Complicated. (2017) (0)
- Author response: TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium (2019) (0)
- Kinetic and Mechanistic Basis of the Nonprocessive Kinesin-3 Motor NcKin (2006) (0)
- Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 (2011) (0)
- Functional characterization of N-terminally truncated myosin II (1998) (0)
- Abstracts of the XVIII European Conference on Muscle and Motility (1990) (0)
- Myosin Binding to Actin in the 3D Sarcomere Lattice (2016) (0)
- Abstracts of the XVIII European Conference on Muscle and Motility (1990) (0)
- Myosin Binding to Human Cardiac Thin Filaments Containing Tropomyosin Carrying DCM & HCM Mutations; Fitting of Complex Binding Transients (2014) (0)
- Cryo-EM and protein–protein docking reveal myosin loop 4 contacts actin and tropomyosin on thin filaments (2020) (0)
- Fabrication and Surface Functionalization of Highly Birefringent Rutile Particles for Trapping in an Optical Torque Wrench (2015) (0)
- Kinetics Of Two Single Point Mutants Of Drosophila Myosin S1 (2009) (0)
- 1 Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on protein stability that destabilise the actin-tropomyosin copolymer in vitro and in vivo (2017) (0)
- Kinetic characterisation of microgram quantities of myosins using a novel flash photolysis apparatus (2002) (0)
- Dcm Mutations in Tropomyosin Induce Loss of Thermal Stability When the Mutation is Present in a Single Chain of the Tm Dimer (2014) (0)
- 1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
- Decision letter: Single molecule mechanics resolves the earliest events in force generation by cardiac myosin (2019) (0)
- The XXVIII European Muscle Conference (1999) (0)
- The XXXVII European muscle conference: Oxford September 2008 (2008) (0)
- TORC2 dependent phosphorylation modulates calcium regulation of fission yeast myosin (2018) (0)
- Kinetic mechanism of myosin IXB and the contributions of two class lX-specific regions. VOLUME 280 (2005) PAGES 38957-38968 (2006) (0)
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What Schools Are Affiliated With Michael A. Geeves?
Michael A. Geeves is affiliated with the following schools:
