Michael H. Gelb
#55,860
Most Influential Person Now
American biochemist
Michael H. Gelb's AcademicInfluence.com Rankings
Michael H. Gelbbiology Degrees
Biology
#3549
World Rank
#5412
Historical Rank
#1431
USA Rank
Biochemistry
#419
World Rank
#498
Historical Rank
#158
USA Rank
Download Badge
Biology
Michael H. Gelb's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, San Diego
Why Is Michael H. Gelb Influential?
(Suggest an Edit or Addition)According to Wikipedia, Professor Michael H. Gelb is an American biochemist and chemist specializing in enzymes and particularly those of medical significance. He is the Boris and Barbara L. Weinstein Endowed Chair in Chemistry at the University of Washington in Seattle. He also teaches Honors Organic Chemistry, Chemical Biology and Enzymology.
Michael H. Gelb's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Quantitative analysis of complex protein mixtures using isotope-coded affinity tags (1999) (4664)
- Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction (2010) (759)
- Biochemistry and physiology of mammalian secreted phospholipases A2. (2008) (502)
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. (2014) (447)
- Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. (1993) (420)
- Prenyl proteins in eukaryotic cells: a new type of membrane anchor. (1990) (395)
- Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development (2008) (377)
- Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen (*) (1995) (339)
- Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2 * (2002) (329)
- Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening. (2004) (315)
- Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. (2005) (297)
- Fluoro ketone inhibitors of hydrolytic enzymes. (1985) (285)
- Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. (2005) (284)
- Human lamin B contains a farnesylated cysteine residue. (1989) (284)
- Interfacial enzymology: the secreted phospholipase A(2)-paradigm. (2001) (265)
- Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis (2014) (248)
- Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2 * (2002) (248)
- Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases* (2000) (237)
- Computational protein design enables a novel one-carbon assimilation pathway (2015) (233)
- Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. (1993) (232)
- 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis (2009) (225)
- Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells* (2000) (216)
- Glycolysis as a target for the design of new anti-trypanosome drugs. (2001) (205)
- Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. (2005) (202)
- Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. (2006) (198)
- Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model (2007) (195)
- Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2. (1995) (191)
- Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2 * (1999) (184)
- Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders (2006) (183)
- A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity. (1991) (180)
- Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparan Sulfate Shuttling and External Plasma Membrane Mechanisms* (2001) (180)
- Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA (2015) (179)
- Novel Human Secreted Phospholipase A2 with Homology to the Group III Bee Venom Enzyme* (2000) (179)
- Groups IV, V, and X Phospholipases A2s in Human Neutrophils (2002) (177)
- The Antibacterial Properties of Secreted Phospholipases A2 (2002) (172)
- Therapeutic intervention based on protein prenylation and associated modifications (2006) (172)
- Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets. (1994) (171)
- Identification of geranylgeranyl-modified proteins in HeLa cells. (1990) (171)
- Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A Expressed in Insect Cells and Present in Human Monocytes (*) (1996) (169)
- On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. (1999) (168)
- Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. (2005) (164)
- Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini. (1990) (162)
- Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system. (1982) (159)
- Identification of the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated Human Platelets and HeLa Cells* (1998) (158)
- Protein Prenylation, et cetera--Signal Transduction in Two Dimensions (1997) (153)
- Cloning and Recombinant Expression of a Structurally Novel Human Secreted Phospholipase A2 * (2000) (152)
- Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor1 (2005) (151)
- Arachidonic Acid Release from Mammalian Cells Transfected with Human Groups IIA and X Secreted Phospholipase A2 Occurs Predominantly during the Secretory Process and with the Involvement of Cytosolic Phospholipase A2-α* (2004) (149)
- The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. (1995) (149)
- Identification of infants at risk for developing Fabry, Pompe, or mucopolysaccharidosis-I from newborn blood spots by tandem mass spectrometry. (2013) (147)
- Improved sensitivity mass spectrometric detection of eicosanoids by charge reversal derivatization. (2010) (144)
- C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester. (1991) (143)
- Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (1994) (138)
- Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. (2008) (137)
- Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. (2003) (134)
- Role of Charge Properties of Bacterial Envelope in Bactericidal Action of Human Group IIA Phospholipase A2against Staphylococcus aureus* (2002) (132)
- Preferential Release of 11-cis-retinol from Retinal Pigment Epithelial Cells in the Presence of Cellular Retinaldehyde-binding Protein* (1999) (128)
- Rational modification of a candidate cancer drug for use against Chagas disease. (2009) (128)
- On the Binding Preference of Human Groups IIA and X Phospholipases A2 for Membranes with Anionic Phospholipids* (2002) (127)
- A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis (2010) (126)
- Drug discovery for malaria: a very challenging and timely endeavor. (2007) (124)
- Cloning and Recombinant Expression of a Novel Mouse-secreted Phospholipase A2 * (1999) (122)
- Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan. (1999) (116)
- Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor. (2007) (115)
- Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry☆ (2016) (114)
- Interfacial Enzymology of Parvovirus Phospholipases A2* (2004) (113)
- Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation Published, JLR Papers in Press, December 7, 2005. (2006) (113)
- High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2. (1992) (112)
- Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation. (1997) (111)
- Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. (1999) (110)
- COPI acts in both vesicular and tubular transport (2011) (110)
- Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling. (1995) (109)
- Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2 * (2001) (109)
- Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product. (1991) (109)
- Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides. (1994) (109)
- Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange. (1995) (109)
- Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A2 (2010) (108)
- Protein cross-linking analysis using mass spectrometry, isotope-coded cross-linkers, and integrated computational data processing. (2006) (107)
- Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. (1994) (106)
- Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism (2010) (104)
- Localization of Structural Elements of Bee Venom Phospholipase A2 Involved in N-type Receptor Binding and Neurotoxicity* (1997) (104)
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis IVA. (2008) (102)
- Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis (2013) (102)
- Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function (2006) (101)
- Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection (2015) (101)
- Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators (2013) (101)
- Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. (2001) (100)
- Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. (1990) (100)
- Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness. (2007) (99)
- A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2. (1995) (98)
- Oncogenic Action of Secreted Phospholipase A2 in Prostate Cancer (2004) (98)
- Conodipine-M, a Novel Phospholipase A2 Isolated from the Venom of the Marine Snail Conus magus(*) (1995) (97)
- Cytosolic Phospholipase A2-α Is Necessary for Platelet-activating Factor Biosynthesis, Efficient Neutrophil-mediated Bacterial Killing, and the Innate Immune Response to Pulmonary Infection (2005) (96)
- Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. (2010) (96)
- Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. (2003) (96)
- Mapping the interfacial binding surface of human secretory group IIa phospholipase A2. (1997) (95)
- The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. (2006) (94)
- Potentiation of Tumor Necrosis Factor α-induced Secreted Phospholipase A2 (sPLA2)-IIA Expression in Mesangial Cells by an Autocrine Loop Involving sPLA2 and Peroxisome Proliferator-activated Receptor α Activation* (2003) (93)
- Inhibition of phospholipase A2 (1994) (93)
- Differential Prenyl Pyrophosphate Binding to Mammalian Protein Geranylgeranyltransferase-I and Protein Farnesyltransferase and Its Consequence on the Specificity of Protein Prenylation* (1997) (92)
- The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. (2014) (90)
- Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance. (1998) (90)
- A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells. (2001) (90)
- Purification of a Protein Palmitoyltransferase that Acts on H-Ras Protein and on a C-terminal N-Ras Peptide* (1996) (90)
- Interfacial catalysis by phospholipase A2: substrate specificity in vesicles. (1991) (89)
- Protein prenylation: from discovery to prospects for cancer treatment. (1998) (89)
- Competitive inhibition of phospholipase A2 in vesicles. (1989) (89)
- Quantification of Tight Binding to Surface-Immobilized Phospholipid Vesicles Using Surface Plasmon Resonance: Binding Constant of Phospholipase A2 (2000) (89)
- Palmitoylation of Ha-Ras Facilitates Membrane Binding, Activation of Downstream Effectors, and Meiotic Maturation in Xenopus Oocytes (*) (1996) (89)
- Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors. (1993) (88)
- Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. (1990) (88)
- Newborn screening for lysosomal storage diseases. (2015) (88)
- Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy (2008) (87)
- Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: application to the determination of substrate preferences. (1993) (84)
- Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme. (1998) (84)
- The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth. (1998) (84)
- Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. (1991) (81)
- Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease. (2004) (81)
- Cytosolic Phospholipase A2-α: A Potential Therapeutic Target for Prostate Cancer (2008) (81)
- The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease. (2005) (80)
- High-throughput assay of 9 lysosomal enzymes for newborn screening. (2013) (80)
- Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum. (2005) (80)
- Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex. (1993) (79)
- Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance. (1999) (79)
- Phospholipases: an overview. (2012) (79)
- Repurposing strategies for tropical disease drug discovery. (2016) (77)
- Group V Secretory Phospholipase A2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans 1 (2009) (77)
- Cellular Arachidonate-releasing Function of Novel Classes of Secretory Phospholipase A2s (Groups III and XII)* (2003) (76)
- Resistance to a Protein Farnesyltransferase Inhibitor in Plasmodium falciparum* (2005) (76)
- Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. (1999) (75)
- Drugs to Combat Tropical Protozoan Parasites (2002) (75)
- Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. (2016) (74)
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots (2008) (74)
- Kinetic basis for interfacial catalysis by phospholipase A2. (1995) (73)
- Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds. (2011) (72)
- Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (2000) (72)
- Crystal Structure of Human Group X Secreted Phospholipase A2 (2002) (71)
- Transglutaminase 2, a Novel Regulator of Eicosanoid Production in Asthma Revealed by Genome-Wide Expression Profiling of Distinct Asthma Phenotypes (2010) (70)
- Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells* (2006) (70)
- Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. (1999) (70)
- A tandem mass spectrometry triplex assay for the detection of Fabry, Pompe, and mucopolysaccharidosis-I (Hurler). (2010) (70)
- Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. (2001) (69)
- Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment (2015) (68)
- Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2 * (2002) (68)
- Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2α activity (2007) (68)
- Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A(2): structure-function studies with vesicle, micelle, and membrane assays. (1999) (68)
- Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. (2000) (68)
- Phospholipase A2-catalyzed hydrolysis of vesicles: uses of interfacial catalysis in the scooting mode. (1991) (67)
- Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes (2009) (67)
- Synthesis and evaluation of phospholipid analogs as inhibitors of cobra venom phospholipase A2 (1987) (66)
- A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents (2003) (66)
- Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. (2007) (65)
- Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2. (1998) (65)
- Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. (1990) (64)
- Interfacial Enzymology: The Secreted Phospholipase A2‐Paradigm (2001) (64)
- Tandem mass spectrometric analysis of dried blood spots for screening of mucopolysaccharidosis I in newborns. (2005) (64)
- Interfacial catalysis by human 85 kDa cytosolic phospholipase A2 on anionic vesicles in the scooting mode. (1997) (64)
- LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity[S] (2013) (64)
- Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. (2001) (63)
- Fluoro ketone phospholipid analogues: new inhibitors of phospholipase A2 (1986) (63)
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis II (Hunter Syndrome). (2010) (62)
- Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A2 in the Regulation of Degranulation and Prostaglandin D2 Synthesis in Mast Cells1 (2000) (62)
- Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. (2000) (61)
- Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. (1998) (61)
- Newborn Screening for Lysosomal Storage Diseases: A Concise Review of the Literature on Screening Methods, Therapeutic Possibilities and Regional Programs (2017) (59)
- A ruler for determining the position of proteins in membranes. (2005) (59)
- Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for mucopolysaccharidosis II (Hunter disease). (2007) (59)
- Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. (2006) (59)
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis I. (2008) (58)
- The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia (2015) (58)
- Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. (2014) (57)
- Lung mast cells are a source of secreted phospholipases A2. (2009) (56)
- Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib (2012) (56)
- Interfacial catalysis by phospholipase A2: activation by substrate replenishment. (1991) (55)
- Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity (2011) (55)
- Correlation of proton release and ultraviolet difference spectra associated with metal binding by transferrin. (1980) (55)
- Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. (2001) (54)
- Inhibitory Effects of Surfactant Protein A on Surfactant Phospholipid Hydrolysis by Secreted Phospholipases A21 (2003) (54)
- Group X Phospholipase A2 Stimulates the Proliferation of Colon Cancer Cells by Producing Various Lipid Mediators (2009) (54)
- Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). (2002) (54)
- Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease (2018) (54)
- Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. (2004) (53)
- Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. (2004) (53)
- Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. (2000) (53)
- Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. (2014) (52)
- Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2ζ in Mouse Lung Fibroblasts* (2007) (52)
- Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes. (2000) (52)
- Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function* (2009) (51)
- Fluoro ketone containing peptides as inhibitors of human renin. (1987) (51)
- Tandem Mass Spectrometry Has a Larger Analytical Range than Fluorescence Assays of Lysosomal Enzymes: Application to Newborn Screening and Diagnosis of Mucopolysaccharidoses Types II, IVA, and VI. (2015) (50)
- Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2. (2003) (50)
- Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles. (1992) (50)
- Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels. (2006) (50)
- Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. (2004) (49)
- Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. (2009) (49)
- Synthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: stereocontrolled enzymatic elimination of hydrogen fluoride (1990) (49)
- Protein Farnesyltransferase from Trypanosoma brucei (1998) (48)
- Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue. (2007) (48)
- Psychosine, a marker of Krabbe phenotype and treatment effect. (2017) (48)
- The Farnesyl Group of H-Ras Facilitates the Activation of a Soluble Upstream Activator of Mitogen-activated Protein Kinase (*) (1995) (48)
- Design and synthesis of visible isotope-coded affinity tags for the absolute quantification of specific proteins in complex mixtures. (2004) (47)
- Lysosomal storage disorder 4+1 multiplex assay for newborn screening using tandem mass spectrometry: application to a small-scale population study for five lysosomal storage disorders. (2012) (47)
- Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X* (2010) (47)
- In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. (2004) (46)
- Cloning, Heterologous Expression, and Distinct Substrate Specificity of Protein Farnesyltransferase from Trypanosoma brucei * (2000) (46)
- PLA2R1 mediates tumor suppression by activating JAK2. (2013) (46)
- A Designed Probe for Acidic Phospholipids Reveals the Unique Enriched Anionic Character of the Cytosolic Face of the Mammalian Plasma Membrane* (2004) (46)
- Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoses and Type 2 Neuronal Ceroid Lipofuscinosis. (2017) (46)
- Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. (2011) (46)
- Direct profiling of multiple enzyme activities in human cell lysates by affinity chromatography/electrospray ionization mass spectrometry: application to clinical enzymology. (2001) (46)
- Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples. (2016) (45)
- Localization of various secretory phospholipase A2 enzymes in male reproductive organs. (2004) (45)
- 2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials. (2008) (45)
- Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β) (2006) (45)
- Unusual Mode of Binding of Human Group IIA Secreted Phospholipase A2 to Anionic Interfaces as Studied by Continuous Wave and Time Domain Electron Paramagnetic Resonance Spectroscopy* (2002) (45)
- Blockade of Human Group X Secreted Phospholipase A2 (GX-sPLA2)-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a Selective GX-sPLA2 Inhibitor* (2011) (45)
- Chemical mechanisms for cytochrome P-450 oxidation: spectral and catalytic properties of a manganese-substituted protein. (1982) (45)
- Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer* (2016) (44)
- Newborn Screening for Lysosomal Storage Diseases: Methodologies, Screen Positive Rates, Normalization of Datasets, Second-Tier Tests, and Post-Analysis Tools (2018) (44)
- Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry[S] (2010) (44)
- Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis. (1998) (43)
- Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation (2003) (43)
- Mechanism of Rhodopsin Activation as Examined with Ring-constrained Retinal Analogs and the Crystal Structure of the Ground State Protein* (2001) (43)
- Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). (2010) (43)
- Taiwan National Newborn Screening Program by Tandem Mass Spectrometry for Mucopolysaccharidoses Types I, II, and VI (2019) (42)
- Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. (2005) (41)
- Multiple enzymatic activities of the human cytosolic 85-kDa phospholipase A2: hydrolytic reactions and acyl transfer to glycerol. (1995) (41)
- Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2. (1999) (41)
- Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism. (2004) (41)
- Comparative triplex tandem mass spectrometry assays of lysosomal enzyme activities in dried blood spots using fast liquid chromatography: application to newborn screening of Pompe, Fabry, and Hurler diseases. (2011) (41)
- Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. (2010) (40)
- Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor. (2006) (40)
- Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. (2005) (40)
- A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. (1998) (40)
- Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA. (2001) (40)
- Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87. (1996) (40)
- Automated affinity capture-release of biotin-containing conjugates using a lab-on-valve apparatus coupled to UV/visible and electrospray ionization mass spectrometry. (2002) (40)
- Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. (2009) (39)
- Synthesis of sulfur-substituted phospholipid analogs as mechanistic probes of phospholipase A2 catalysis (1989) (39)
- Regulation and function of epithelial secreted phospholipase A2 group X in asthma. (2013) (39)
- Structural genomics of pathogenic protozoa: an overview. (2008) (39)
- Bacterial N-succinyl-L-diaminopimelic acid desuccinylase. Purification, partial characterization, and substrate specificity. (1988) (39)
- Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin. (2005) (38)
- Pathway-oriented profiling of lipid mediators in macrophages. (2005) (38)
- Prenylation of proteins in Trypanosoma brucei. (1997) (38)
- Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. (2008) (38)
- Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis. (2017) (38)
- Group X Secretory Phospholipase A2 Negatively Regulates ABCA1 and ABCG1 Expression and Cholesterol Efflux in Macrophages (2010) (37)
- Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes. (2005) (37)
- Phosphonate-containing phospholipid analogues as tight-binding inhibitors of phospholipase-A2 (1988) (37)
- Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase (2007) (37)
- Localization and function of cytosolic phospholipase A2alpha at the Golgi. (2010) (37)
- Improved Reagents for Newborn Screening of Mucopolysaccharidosis Types I, II, and VI by Tandem Mass Spectrometry (2014) (36)
- Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags. (2007) (36)
- Interaction of 5-bromocamphor with cytochrome P-450 cam. Production of 5-ketocamphor from a mixed spin state hemoprotein. (1981) (36)
- Probing Phospholipase A2 with Fluorescent Phospholipid Substrates (2007) (36)
- sPLA2 and the epidermal barrier. (2014) (36)
- Analysis of Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass Spectrometry (1999) (35)
- Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. (2009) (35)
- Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis. (2003) (35)
- Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins. (2009) (34)
- Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. (2006) (34)
- Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. (2009) (34)
- TcRho1, a Farnesylated Rho Family Homologue from Trypanosoma cruzi (2001) (33)
- Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2. (1995) (33)
- Biochemical and Physiological Properties of Rhodopsin Regenerated with 11-cis-6-Ring- and 7-Ring-retinals* (2002) (33)
- Protection of a Decapeptide from Proteolytic Cleavage by Lipidation and Self-Assembly into High-Axial-Ratio Microstructures: A Kinetic and Structural Study (1999) (33)
- The δ Subunit of Type 6 Phosphodiesterase Reduces Light-induced cGMP Hydrolysis in Rod Outer Segments* (2001) (33)
- Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. (2011) (33)
- A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide. (1993) (32)
- Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Inflammation and Fever (2015) (32)
- Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. (2009) (32)
- Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2β) and Comparison with the Other cPLA2 Isoforms* (2010) (32)
- Group X Secreted Phospholipase A2 Proenzyme Is Matured by a Furin-like Proprotein Convertase and Releases Arachidonic Acid inside of Human HEK293 Cells* (2011) (31)
- Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro (2006) (31)
- A novel form of rhodopsin kinase from chicken retina and pineal gland 1 (1999) (31)
- Inactivation of chymotrypsin by 5-benzyl-6-chloro-2-pyrone: 13C NMR and X-ray diffraction analyses of the inactivator-enzyme complex. (1985) (31)
- A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. (2001) (31)
- Group X Secretory Phospholipase A2 Enhances TLR4 Signaling in Macrophages (2011) (30)
- Newborn Screening for Lysosomal Storage Disorders: Methodologies for Measurement of Enzymatic Activities in Dried Blood Spots (2018) (30)
- Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels. (2004) (30)
- Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. (2005) (29)
- Formation of high-axial-ratio-microstructures from natural and synthetic sphingolipids. (1997) (29)
- Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. (2007) (29)
- A Bifunctional Role for Group IIA Secreted Phospholipase A2 in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism* (2010) (29)
- The critical role of psychosine in screening, diagnosis, and monitoring of Krabbe disease (2020) (29)
- Structural characterization of prenyl groups attached to proteins (1990) (29)
- Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation* (2013) (28)
- Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease. (2017) (28)
- Group X Secretory Phospholipase A2 Regulates the Expression of Steroidogenic Acute Regulatory Protein (StAR) in Mouse Adrenal Glands* (2010) (28)
- Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction (2020) (28)
- Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns (2020) (28)
- Facial thermography, basis, protocol, and clinical value. (1991) (27)
- Substituted isatoic anhydrides: selective inactivators of trypsin-like serine proteases. (1986) (27)
- Use of thermal melt curves to assess the quality of enzyme preparations. (2010) (27)
- Kinetic Evaluation of Cell Membrane Hydrolysis during Apoptosis by Human Isoforms of Secretory Phospholipase A2* (2010) (26)
- Human plasma lecithin-cholesterol acyltransferase. Inhibition of the phospholipase A2-like activity by sn-2-difluoroketone phosphatidylcholine analogues. (1989) (26)
- Geranylgeranylated proteins : Molecular and immunological approaches to the study of synaptic and axonal glycoproteins (1992) (25)
- Cytochrome P450cam catalyzed epoxidation of dehydrocamphor. (1982) (25)
- Assaying phospholipase A2 activity. (2004) (25)
- The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. (2006) (25)
- Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei. (2012) (25)
- Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. (2017) (25)
- Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation. (1999) (24)
- Antigenic surface of the bee venom allergen phospholipase A2. Structural functional analysis of human IgG4 antibodies reveals potential role in protection. (1994) (24)
- New substrates and enzyme assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome) types A, B, C, and D by tandem mass spectrometry. (2012) (24)
- Tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening. (2007) (24)
- Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry. (2010) (24)
- The prenylation of proteins (1991) (24)
- Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2. (1997) (23)
- Continuous and highly variable rate controlled release of model drugs from sphingolipid-based complex high axial ratio microstructures. (2001) (23)
- 2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability. (2008) (23)
- 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors (2016) (23)
- Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity (2004) (23)
- Interfacial enzymology of phospholipase A2 (1992) (23)
- Competitive inhibition of interfacial catalysis by phospholipase A2: differential interaction of inhibitors with the vesicle interface as a controlling factor of inhibitor potency (1993) (23)
- Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (2006) (23)
- Replacement of the H-Ras farnesyl group by lipid analogues: implications for downstream processing and effector activation in Xenopus oocytes. (1997) (22)
- Functional characterization of mutations in inherited human cPLA₂ deficiency. (2011) (22)
- Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover. (1992) (22)
- Substrate specificity of mammalian prenyl protein-specific endoprotease activity. (1998) (22)
- C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins. (2007) (22)
- Assay of phospholipases A2 and their inhibitors by kinetic analysis in the scooting mode (1992) (22)
- Surface-enhanced transmission mode desorption electrospray ionization: increasing the specificity of ambient ionization mass spectrometric analyses. (2010) (22)
- Newborn Screening for Mucopolysaccharidoses: Results of a Pilot Study with 100 000 Dried Blood Spots. (2019) (22)
- Bio-organic chemistry and cytochrome P-450-dependent catalysis. (1984) (22)
- Cytosolic Phospholipase A2-α Is Necessary for Platelet-activating Factor Biosynthesis, Efficient Neutrophil-mediated Bacterial Killing, and the Innate Immune Response to Pulmonary Infection: cPLA2-α DOES NOT REGULATE NEUTROPHIL NADPH OXIDASE ACTIVITY* (2008) (21)
- Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma. (2016) (21)
- Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes* (2013) (21)
- Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase. (2002) (21)
- Newborn screening for Krabbe's disease (2016) (21)
- Quantification of sulfatides in dried blood and urine spots from metachromatic leukodystrophy patients by liquid chromatography/electrospray tandem mass spectrometry. (2014) (21)
- Mechanism of inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. (1984) (21)
- 1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy (2017) (21)
- Newborn Screening for Lysosomal Storage Disorders: Quo Vadis? (2016) (20)
- Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes. (2010) (20)
- Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. (2001) (20)
- Protein prenyltransferases : Isoprenoids - Biosynthesis and role in the regulation of protein function (1992) (20)
- Group V Phospholipase A2 in Bone Marrow-derived Myeloid Cells and Bronchial Epithelial Cells Promotes Bacterial Clearance after Escherichia coli Pneumonia* (2011) (20)
- N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease (2019) (20)
- X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone. (1986) (20)
- Epithelial regulation of eicosanoid production in asthma. (2012) (20)
- Liquid Chromatography-Tandem Mass Spectrometry Assay of Leukocyte Acid α-Glucosidase for Post-Newborn Screening Evaluation of Pompe Disease. (2017) (20)
- Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. (2016) (20)
- Design and synthesis of substrate and internal standard conjugates for profiling enzyme activity in the Sanfilippo syndrome by affinity chromatography/electrospray ionization mass spectrometry. (2001) (19)
- Synthetic prenylated peptides: studying prenyl protein-specific endoprotease and other aspects of protein prenylation. (1995) (19)
- Kinetic characterization of phospholipase A2 modified by manoalogue. (1991) (19)
- Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. (2016) (19)
- Quantification of cellular acid sphingomyelinase and galactocerebroside beta-galactosidase activities by electrospray ionization mass spectrometry. (2001) (19)
- Lymphocyte Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation of Krabbe Disease. (2017) (19)
- Key Role of Group V Secreted Phospholipase A2 in Th2 Cytokine and Dendritic Cell-Driven Airway Hyperresponsiveness and Remodeling (2013) (18)
- Rapid and selective screening for sulfhydryl analytes in plasma and urine using surface-enhanced transmission mode desorption electrospray ionization mass spectrometry. (2010) (18)
- Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes. (2000) (18)
- Expression and Function of Group IIE Phospholipase A2 in Mouse Skin* (2016) (18)
- Phthalimide resin reagent for efficient mitsunobu amino-dehydroxylation (1998) (18)
- Expression of phospholipases A2 and C in human corneal epithelial cells. (2004) (18)
- On the Diversity of Secreted Phospholipases A2 (1999) (17)
- Tandem Mass Spectrometry Assays of Palmitoyl Protein Thioesterase 1 and Tripeptidyl Peptidase Activity in Dried Blood Spots for the Detection of Neuronal Ceroid Lipofuscinoses in Newborns (2014) (17)
- Specific Substrate for the Assay of Lysosomal Acid Lipase. (2018) (17)
- Preparation of the Full Set of Recombinant Mouse- and Human-Secreted Phospholipases A2. (2017) (17)
- Differential modulation of mediator release from human basophils and mast cells by mizolastine (2004) (16)
- Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib. (2003) (16)
- An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids (2000) (16)
- Function of secreted phospholipase A2 group-X in asthma and allergic disease. (2019) (16)
- Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection (2014) (16)
- Cytosolic Phospholipase A2 Enzymes Are Not Required by Mouse Bone Marrow-Derived Macrophages for the Control of Mycobacterium tuberculosis In Vitro (2006) (16)
- Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis. (2018) (15)
- Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. (2005) (15)
- Metal affinity capture tandem mass spectrometry for the selective detection of phosphopeptides. (2006) (15)
- Toward Newborn Screening of Cerebrotendinous Xanthomatosis: Results of a Biomarker Research Study Using 32,000 Newborn Dried Blood Spots (2020) (15)
- Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. (2008) (15)
- Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents. (2009) (15)
- The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation (2022) (14)
- Protein geranylgeranyltransferase-I of Trypanosoma cruzi. (2008) (14)
- Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8. (1998) (14)
- Protonation sites and dissociation mechanisms of t-butylcarbamates in tandem mass spectrometric assays for newborn screening. (2011) (14)
- Dataset and standard operating procedure for newborn screening of six lysosomal storage diseases: By tandem mass spectrometry (2016) (14)
- Zero-order interfacial enzymatic degradation of phospholipid tubules. (1997) (14)
- New Class of Antitrypanosomal Agents Based on Imidazopyridines. (2017) (13)
- A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor. (2003) (13)
- Formation of high axial ratio microstructures from peptides modified with glutamic acid dialkyl amides. (1998) (13)
- Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A(2) and hyaluronic acid-linked inhibitor conjugates. (2012) (13)
- Action of Human Group IIa Secreted Phospholipase A2on Cell Membranes (1998) (13)
- Interfacial catalysis by phospholipase A2: evaluation of the interfacial rate constants by steady-state isotope effect studies. (1991) (13)
- Toward newborn screening of metachromatic leukodystrophy: results from analysis of over 27,000 newborn dried blood spots (2020) (13)
- Incidence and carrier frequency of Sandhoff disease in Saskatchewan determined using a novel substrate with detection by tandem mass spectrometry and molecular genetic analysis. (2014) (13)
- Respective contribution of cytosolic phospholipase A2α and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis. (2019) (12)
- Tandem mass spectrometry-based multiplex assays for α-mannosidosis and fucosidosis. (2019) (12)
- Binding of xylenol orange to transferrin. Demonstration of metal-anion linkage. (1980) (11)
- Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. (2018) (11)
- Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase. (2002) (11)
- Regulation of cytosolic phospholipase A2α by hsp90 and a p54 kinase in okadaic acid‐stimulated macrophages (2008) (11)
- Geranylgeranylated proteins. (1992) (11)
- Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A. (2004) (11)
- Faculty Opinions recommendation of Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. (2012) (11)
- Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents. (2013) (11)
- Reliable Assay of Acid Sphingomyelinase Deficiency with the Mutation Q292K by Tandem Mass Spectrometry. (2015) (11)
- In Vitro Anti-Plasmodium falciparum Properties of the Full Set of Human Secreted Phospholipases A2 (2015) (11)
- Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. (2021) (10)
- Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI. (2015) (10)
- Comparison of tandem mass spectrometry to fluorimetry for newborn screening of LSDs (2017) (10)
- Leukocyte and Dried Blood Spot Arylsulfatase A Assay by Tandem Mass Spectrometry. (2020) (10)
- Evaluation of Multiple Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis-I (2020) (10)
- Corrigendum to “A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells.” [Biochem. Biophys. Acta 1513 (2001) 160–166] (2011) (9)
- Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. (2016) (9)
- Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. (2017) (9)
- Achieving Congruence among Reference Laboratories for Absolute Abundance Measurement of Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe Disease (2020) (9)
- Protein structure-based design of anti-protozoal drugs (2002) (9)
- Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors. (2017) (9)
- Short synthetic sequence for 2-sulfation of alpha-L-iduronate glycosides. (2009) (9)
- Cross‐presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA2 as a membrane‐binding vector (2005) (9)
- A highly multiplexed biochemical assay for analytes in dried blood spots: application to newborn screening and diagnosis of lysosomal storage disorders and other inborn errors of metabolism (2020) (8)
- Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics. (1998) (8)
- Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. (2008) (8)
- Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni (2019) (8)
- Lysine residues in bee venom phospholipase A2 are important for binding to human monoclonal or polyclonal antibodies of the IgG4 isotope. (1994) (7)
- Characterization of interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode. (1994) (7)
- Exploring the specificity of prenyl protein-specific methyltransferase with synthetic prenylated rab peptides (1995) (7)
- Cytosolic Phospholipase A 2 - (cid:1) Is Necessary for Platelet-activating Factor Biosynthesis, Efficient Neutrophil-mediated Bacterial Killing, and the Innate Immune Response to Pulmonary Infection - (cid:1) DOES NOT REGULATE NEUTROPHIL NADPH OXIDASE ACTIVITY* (cPLA (2005) (7)
- Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. (2018) (7)
- Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry . Evaluation of the Impact of Secreted Phospholipase A 2 on Microparticle Assessment (2015) (7)
- Evaluation of Multiple Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis-I. (2020) (7)
- The future of newborn screening for lysosomal disorders (2021) (7)
- Thermophysiologic anthropometry of the face in Homo sapiens. (1990) (7)
- Structural analysis of protein prenyl groups and associated C-terminal modifications. (2000) (7)
- Quantitative and structural analysis of inhibitors of phospholipase A2 (1991) (7)
- The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high axial ratio microstructures. (2001) (6)
- Cytosolic Phospholipase A 2-Is Necessary for Platelet-activating Factor Biosynthesis , Efficient Neutrophil-mediated Bacterial Killing , and the Innate Immune Response to Pulmonary Infection cPLA (2004) (6)
- 1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library. (1999) (6)
- Crystal structure of bee-venom phospholipase A2: correction (1991) (6)
- The Importance of Assay Imprecision near the Screen Cutoff for Newborn Screening of Lysosomal Storage Diseases (2019) (6)
- Consensus recommendations for the classification and long-term follow up of infants who screen positive for Krabbe Disease. (2021) (6)
- Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Porphobilinogen deaminase. (2008) (5)
- In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease. (2022) (5)
- Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung (2020) (5)
- Multiplex tandem mass spectrometry assay for newborn screening of X-linked adrenoleukodystrophy, biotinidase deficiency, and galactosemia with flexibility to assay other enzyme assays and biomarkers. (2018) (5)
- Repurposing Strategies for Tropical Disease Drug Discovery (2016) (5)
- Comparison of the antibody response to bee venom phospholipase A2 induced by natural exposure in humans or by immunization in mice (1997) (5)
- Membrane-binding domain of the small G protein G 25 K contains an S-( all-trans-geranylgeranyl ) cysteine methyl ester at its carboxyl terminus ( prenylation / carboxyl methylation / signal transduction ) (5)
- The farnesyl group activates Ras toward guanine nucleotide exchange catalyzed by the SOS protein (1997) (5)
- Unusual four-bond secondary H/D isotope effect supports a short-strong hydrogen bond between phospholipase A2 and a transition state analogue inhibitor. (2005) (5)
- A Pilot Program Screening for Fabry, Pompe, and MPS I in a Newborn Screening Laboratory: The First 60,000 Samples (2012) (4)
- Phosphonate-phospholipid analogues inhibit human phospholipase A2 (1991) (4)
- An Inexpensive, In-House-Made, Microdialysis Device for Measuring Drug-Protein Binding. (2018) (4)
- Tandem Mass Spectrometry Enzyme Assays for Multiplex Detection of 10-Mucopolysaccharidoses in Dried Blood Spots and Fibroblast. (2020) (4)
- Absolute Amounts of Analytes: When Gravimetric Methods Are Insufficient. (2018) (4)
- Crystal structure of bee-venom phospholipase A2 (1991) (4)
- Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach (2020) (4)
- Family Attitudes regarding Newborn Screening for Krabbe Disease: Results from a Survey of Leukodystrophy Registries (2020) (4)
- Performance of 10 Systems for Self- Monitoring of Blood Glucose by Trained Healthcare Professionals and in the Hands of the Users (4)
- Detection of GM1‐gangliosidosis in newborn dried blood spots by enzyme activity and biomarker assays using tandem mass spectrometry (2020) (4)
- Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500230-JLR200 (2005) (4)
- Critical challenges and emerging paradigms in drug discovery. (2010) (4)
- Tri £ uoromethyl ketones and methyl £ uorophosphonates as inhibitors of group IV and VI phospholipases A 2 : structure-function studies with vesicle , micelle , and membrane assays 1 (1999) (4)
- ScreenPlus: A comprehensive, dynamic, multi-disorder newborn screening pilot program (2020) (3)
- Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles (2016) (3)
- Study of the Role of Cytosolic Phospholipase A2 Alpha in Eicosanoid Generation and Thymocyte Maturation in the Thymus (2015) (3)
- Neuron-specific ablation of the Krabbe disease gene galactosylceramidase in mice results in neurodegeneration (2022) (3)
- Evaluation of Two Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis Type II (2022) (3)
- Mass Spectrometry but not Fluorimetry Distinguishes Affected and Pseudodeficienies in Newborn Screening for Pompe Disease (2017) (3)
- Erratum: Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system (Biochemistry (1982) 21, 2, (370-377)) (1982) (3)
- A Case of Lysosomal Acid Lipase Deficiency Confirmed by Response to Sebelipase Alfa Therapy. (2020) (3)
- Cytosolic Phospholipase A2-A: A Potential TherapeuticTarget for Prostate Cancer (2008) (3)
- Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. (2010) (3)
- Exercise-Induced Alterations in Phospholipid Hydrolysis, Airway Surfactant and Eicosanoids and their Role in Airway Hyperresponsiveness in Asthma. (2021) (3)
- Secretory Phospholipase A 2 Negatively Regulates ABCA 1 and ABCG 1 Expression and Cholesterol Efflux in Macrophages (2010) (2)
- A rapid and non-invasive proteomic analysis using DBS and buccal swab for multiplexed second-tier screening of Pompe disease and Mucopolysaccharidosis type I. (2022) (2)
- A high performance assay for the detection of MPS disorders, MLD, and CTX, from newborn blood spots (2018) (2)
- 2-Oxo-tetrahydro-1,8-naphthyridines as Selective Inhibitors of Malarial Protein Farnesyltransferase and as Antimalarials. (2008) (2)
- Fluoro Ketone Phospholipid Analogues: New Inhibitors of Phospholipase A2. (1986) (2)
- High-throughput assay of secreted phospholipases A₂ inhibitors. (2012) (2)
- [Phospholipase A2 inhibitor]. (2000) (2)
- One-step synthesis of carbon-13-labeled globotriaosylsphingosine (lyso-Gb3), an internal standard for biomarker analysis of Fabry disease. (2018) (2)
- Protein prenyltransferases. (1992) (2)
- A simple and inexpensive device for removal of solvent from a large collection of sample tubes. (2006) (2)
- Probing the role of H-Ras lipidation for signaling functions in Xenopus laevis oocytes. (1999) (1)
- autocrine loop involving secreted phospholipase A2 and PPARα activation (2003) (1)
- 81. A novel, MS/MS assay to detect Tay-Sachs and Sandhoff disease using dried blood spots (2010) (1)
- Corrections to Rational modification of a candidate cancer drug for use against Chagas disease (Journal of Medicinal Chemistry (2009) 52, (1639-1646) DOI (2009) (1)
- Liquid Chromatography–Tandem Mass Spectrometry in Newborn Screening Laboratories (2022) (1)
- An Alternate Preparation of Thioester Resin Linkers for Solid-Phase Synthesis of Peptide C-Terminal Thioacids. (2000) (1)
- Effects of cyclodextrin analogs on psychosine cytotoxicity (2020) (1)
- Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2. (2010) (1)
- Newborn screening for Cerebrotendinous Xanthomatosis: A retrospective biomarker study using both flow-injection and UPLC-MS/MS analysis in 20,000 newborns. (2022) (1)
- Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads. (2021) (1)
- Principles of Inhibition of Phospholipase A2 and Other Interfacial Enzymes (1997) (1)
- A universal newborn and diagnostic screening platform for lysosomal diseases and beyond (2020) (1)
- Newborn screening (NBS) for metachromatic leukodystrophy (MLD): results from a study of 100,000 deidentified NBS samples (2017) (1)
- C terminus of the small GTP-binding protein smg p 25 A contains two geranylgeranylated cysteine residues and a methyl ester ( ras p 21 / prenylation / geranylgeranylation / methylation ) (1)
- Platelets in Thrombotic and Non-thrombotic Disorders: Platelet phospholipases A2 (2002) (1)
- Laboratory reliability and validity for measuring psychosine concentration and GALC enzyme activity for use in newborn screening for Krabbe disease (2018) (1)
- Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A 2 (cPLA 2 ) and Comparison with (2010) (1)
- by Producing Various Lipid Mediators (2009) (1)
- 5 Protein geranylgeranyltransferase type I (2001) (1)
- Mouse Groups I, II, V, X, and XII Secreted Phospholipases A 2 (2002) (1)
- Relationship Between Airway Expression Of Secreted Phospholipase A2 Group X And Airway Hyperresponsiveness (2011) (1)
- Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency (2022) (1)
- Protein lipidation protocols (1999) (1)
- Direct Assay of δ -Aminolevulinic Acid Dehydratase in Heme Biosynthesis for the Detection of Porphyrias by Tandem Mass Spectrometry (2010) (1)
- 2.13 – Protein Prenylation (1999) (1)
- Validation of Liquid Chromatography-Tandem Mass Spectrometry-Based 5-Plex Assay for Mucopolysaccharidoses (2020) (1)
- Secretory Phospholipase A 2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans 1 (2009) (1)
- Successful screening of 100,000+ newborns for Fabry, Pompe, Mucopolysaccharidosis-I by tandem mass spectroscopy (2013) (1)
- Protein prenylation in trypanosomatids: A new piggy-back medicinal chemistry target for the development of agents against tropical diseases (2000) (1)
- Facile preparation of leukotrienes C(4), D(4) and E(4) containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry. (2007) (1)
- Pilot Study of Newborn Screening for Six Lysosomal Diseases in Brazil (2023) (0)
- OF THE SYNAPTIC VESICLE CYCLE : DISTINCT MODES OF EXOCYTOSIS (2010) (0)
- 444 DEVELOPMENT OF NEW DRUGS FOR CHAGAS DISEASE. (2006) (0)
- Newborn screening for six lysosomal diseases: Pilot study in Brazil (2020) (0)
- Multiplex UPLC-MS/MS assay of 8 lysosomal disorders in newborn screening (2018) (0)
- The performance characteristics of a 6-plex assay for the detection of six lysosomal diseases and preliminary data for the detection of MPS II, MPS IVA and MPS VI (2016) (0)
- Functionally selective inhibition of Group IIA phospholipase A 2 reveals a role for vimentin in regulating arachidonic acid metabolism (2014) (0)
- In utero enzyme replacement therapy in a fetus with infantile-onset Pompe disease (2022) (0)
- Corrections to Rational Modification of a Candidate Cancer Drug for Use against Chagas Disease (2009) (0)
- Prostaglandin D in the Regulation of Degranulation and 2 II Subfamily of Secretory Phospholipases A Granule-Associated Heparin-Binding Group Redundant and Segregated Functions of (2000) (0)
- LE-4. Pharmacological control of atherosclerotic plaques (1997) (0)
- Identification of Transglutaminase 2 (TGM2) as a Novel Regulator of Eicosanoid-Mediated Inflammation in Asthma. (2009) (0)
- PHOSPHOGLYCERATE KINASE FROM TRYPANOSOMA BRUCEI BISUBSTRATE ANALOG (1998) (0)
- ReceptorMacrophages Expressing the M-Type in Human Lung 2 Secreted Phospholipase A Activation of Cytokine Production by (2004) (0)
- The Expanding Family of Secreted Phospholipases A2: diversity of enzymes for diverse functions? (2000) (0)
- Newborn Screening of Premature Infants : Clinical Trial Data Suggests Gestational Age and Chronological Age are Key to Interpretation (2014) (0)
- Signature biomarkers for diagnosis, screening, and biochemical monitoring of the mucopolysaccharidoses (2023) (0)
- Supporting Online Material for Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction (2010) (0)
- Multiplex MS/MS method to measure MPS II, MPS IIIB, MPS IVA, MPS VI enzyme activities in dried blood spots (2016) (0)
- Newborn screening for lysosomal disease by tandem mass spectrometry: From development to worldwide implementation (2015) (0)
- Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one (2012) (0)
- Faculty Opinions recommendation of Quantifying the global cellular thiol-disulfide status. (2009) (0)
- Glycosaminoglycan biomarkers in newborn dried blood spots to support newborn screening of MPS disorders (2020) (0)
- Faculty of 1000 evaluation for Feedback activation of factor XI by thrombin does not occur in plasma. (2012) (0)
- Faculty Opinions recommendation of Modulation of Rab GTPase function by a protein phosphocholine transferase. (2011) (0)
- 2 A Phospholipases and Group X Secreted Macrophages Induced by Group IIA Growth Factors from Human Lung Production of Vascular Endothelial (2010) (0)
- Newborn screening for six lysosomal diseases in Brazil: Pilot study update (2021) (0)
- Faculty Opinions recommendation of Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. (2008) (0)
- Crystal Structure of Leishmania mexicana GPDH Complexed with Inhibitor 2-bromo-6-hydroxy-purine (2002) (0)
- Synthesis and Structure—Activity Relationships of Adenosine Analogues as Inhibitors of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase. Modifications at Positions 5′ and 8. (1999) (0)
- Screenplus: A model for collective funding of pilot newborn screening (2022) (0)
- Improved method for the quantifi cation of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry (0)
- Hydrophobic α-Amino acids favour the inhibition of human GIIA phospholipase A2 by 2-Oxoamides (2012) (0)
- 17 The pharmacological control of the mevalonate pathway regulates arterial smooth muscle cell proliferation (1997) (0)
- Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots (2020) (0)
- 33 Screening of newborns for lysosomal storage diseases (2007) (0)
- Interleukin la Causes Rapid Activation of Cytosolic Phospholipase A2 by Phosphorylation in Rat Mesangial Cells (2003) (0)
- Tandem mass spectrometry of 15 lysosomal diseases, biotinidase deficiency and galactosemia type 1 at 2.4 minutes per assay (2019) (0)
- Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A 2 to Modulate In fl ammation and Fever (2015) (0)
- Secreted Phospholipase A2 Inhibitors (2008) (0)
- Relationship between Airway Levels of Secreted Phospholipase A2Group X (sPLA2-X) and Asthma Severity. (2009) (0)
- Newborn screening for Morquio syndrome: Results from the 8-plex assay for 70,000 newborns (2020) (0)
- INTERFACIAL ENZYMOLOGY OF GL YCEROLIPID HYDROLASES : Lessons From Secreted Phospholipases A 2 1 (2002) (0)
- Biomarkers of disease severity in multiple sulfatase deficiency (2023) (0)
- Secreted Phospholipase A2Group X-Mediated Activation of Eosinophil Leukotriene Synthesis. (2009) (0)
- WITHDRAWN: Newborn screening for lysosomal disordersby tandem mass spectrometry. (2014) (0)
- Cell modeling and assay development for Krabbe disease (2020) (0)
- Comparison of psychosine analysis in dried blood spots and red blood cells in Krabbe disease (2021) (0)
- Effect of secreted phospholipase A2 group IID, IIE, and IIF-deficiency on allergen-driven asthma phenotype (2013) (0)
- Faculty Opinions recommendation of A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (2004) (0)
- Peptides and peptide derivatives, their preparation, their use in therapeutic and pharmaceutical compositions containing them (1986) (0)
- Screening of approved drugs identifies 3 generation retinoids as therapeutic agents in multiple sulfatase deficiency (2023) (0)
- Faculty Opinions recommendation of Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. (2003) (0)
- Microsoft Word-JBC_Submisison_Revised_Text.docx (2012) (0)
- Metachromatic leukodystrophy: tandem mass spectrometry determination of sulfatide species in dried urine and blood spots (2014) (0)
- Faculty Opinions recommendation of Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. (2010) (0)
- The influence of zinc ion in measurement of leukocyte acid sphingomyelinase activity (2018) (0)
- High accuracy enzymatic assay for enhanced second-tier followup of lysosomal diseases (2018) (0)
- Selective Inhibition of Human Group IIA-secreted Phospholipase A 2 ( hGIIA ) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid (2013) (0)
- Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: mechanistic implications and potential drug binding sites (1996) (0)
- 4.02 – Protein Palmitoylation (1999) (0)
- Probing Adsorption / Desorption Processes at the Liquid / Solid Interface: Thiols and Proteins (2001) (0)
- Binding of hGIIA sPLA 2 to Anionic Interfaces 30985 (2002) (0)
- Iconographies supplémentaires de l'article : Epithelial regulation of eicosanoid production in asthma (2012) (0)
- Corrections - Stereochemistry and Deuterium Effects in Camphor Hydroxylation by the Cytochrome P450cam Monoxygenase System (1982) (0)
- Faculty Opinions recommendation of Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. (2004) (0)
- Analysis of Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass SpectrometryJ. Am. Chem. Soc.1999,121, 1102−1103 (1999) (0)
- Protein Prenylation in Trypanosomatids (2001) (0)
- 39. Newborn screening for lysosomal storage disorders: Tandemmass spectrometry to quantitate enzymatic activity (2010) (0)
- A Biocatalytic Diels-Alder Reaction Using a DesignedEnzyme (2011) (0)
- Psychosine: A useful biomarker for newborn screening, follow up and monitoring of Krabbe disease (2018) (0)
- A pilot study for newborn screening of metachromatic leukodystrophy (2016) (0)
- 2 Phospholipases A Induced by Group IIA and Group X Secreted Factors from Human Lung Macrophages Production of Vascular Endothelial Growth (2010) (0)
- Newborn screening and post-screening diagnosis of lysosomal diseases (2017) (0)
- LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS (2001) (0)
- A highly multiplexed biochemical assay for analytes in dried blood spots: application to newborn screening and diagnosis of lysosomal storage disorders and other inborn errors of metabolism (2020) (0)
- The Role of Phospholipases A2 in Eicosanoid Generation and Airway Inflammation (2007) (0)
- Synthesis and Study of Small-Molecule Inhibitors of Secreted Phospholipase A2 (2008) (0)
- 2 Secreted Phospholipases A Surfactant Phospholipid Hydrolysis by Inhibitory Effects of Surfactant Protein A on (2003) (0)
- Newborn screening of mucopolysaccharidosis II (Hunter syndrome) and VI (Maroteaux-Lamy syndrome) using flow injection tandem mass spectrometry and newly developed reagents (2014) (0)
- Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism (2012) (0)
- On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian Enzymes and HIV-1 Antiviral Properties (2001) (0)
- Formation of high axial ratio microstructures from glutamic acid dihexadecyl amide (1999) (0)
- CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH 2-FLUORO-6-CHLOROPURINE (2002) (0)
- Scientific, clinical, social, and policy status and considerations for implementing newborn screening of metachromatic leukodystrophy (2020) (0)
- Fluorinated/chlorinated peptides (1986) (0)
- Making Decisions About Krabbe Disease Newborn Screening. (2022) (0)
- Faculty Opinions recommendation of Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. (2010) (0)
- Stratification of patients with lysosomal acid lipase deficiency by enzyme activity in dried blood spots (2022) (0)
- Identification of newborn infants at risk for a lysosomal disease by tandem mass spectrometry (2015) (0)
- Synthesis of 3-Fluorodiaminopimelic Acid Isomers as Inhibitors of Diaminopimelate Epimerase: Stereocontrolled Enzymatic Elimination of Hydrogen Fluoride. (1990) (0)
- Enhances TLR4 Signaling in Macrophages2 Group X Secretory Phospholipase A (0)
- Six-plex MS/MS method to measure I2S, NAGLU, GALNS, ARSB, GUSB and TPP1 enzyme activities in dried blood spots (2017) (0)
- Identification Of Epithelial Phospholipase A2 Receptor 1 (pla2r1) As A Target In Asthma (2014) (0)
- Chapter 14 Modification of proteins by prenyl groups (1995) (0)
- 1 A BIFUNCTIONAL ROLE FOR GROUP IIA SECRETED PHOSPHOLIPASE A 2 IN HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTE ARACHIDONIC ACID METABOLISM (2010) (0)
- A glimpse into the feasibility of next generation sequencing for newborn screening of lysosomal and other diseases with second-tier biochemical assays as part of the screening process (2023) (0)
- New peptides and peptide derivatives, their manufacture and use and containing pharmaceutical preparations (1986) (0)
- against Regulates the Innate Immune Response Modulates Phagosome Maturation and 2 Group V Secretory Phospholipase A (2009) (0)
- In utero enzyme replacement therapy in fetuses with lysosomal diseases: A phase I clinical trial (2021) (0)
- Filtered feedthrough for implantable medical devices and method of manufacture (1997) (0)
- Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease (2022) (0)
- Evaluation of Two Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Various Mucopolysaccharidoses and GM1 Gangliosidosis (2023) (0)
- Pilot study update: Newborn screening for lysosomal disorders in Brazil (2022) (0)
- Disease correction in Mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector. (2022) (0)
- EXPANSION OF THE LC-MS/MS PLATFORM WITH THE NEWBORN SCREENING OF X-ALD, POMPE DISEASE AND MPS-I WITH ONE DBS PUNCH (2023) (0)
- Faculty Opinions recommendation of Multiplex genome engineering using CRISPR/Cas systems. (2013) (0)
- A rapid and non-invasive proteomic analysis using DBS and buccal swab for multiplexed second-tier screening of Pompe disease and Hurler syndrome (2022) (0)
- The critical role of psychosine in screening, diagnosis, and monitoring of Krabbe disease (2020) (0)
- Newborn screening for metachromatic leukodystrophy (MLD): An overview of ongoing and future studies (2023) (0)
- Age-related dysregulation in the lipidome compromises the immune response to the severe acute respiratory coronavirus (VIR5P.1140) (2015) (0)
- Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency (2023) (0)
This paper list is powered by the following services:
Other Resources About Michael H. Gelb
What Schools Are Affiliated With Michael H. Gelb?
Michael H. Gelb is affiliated with the following schools:
- University of Zurich
- University of Southampton
- University of California, Berkeley
- University of Texas at Austin
- Uppsala University
- University of Oxford
- University of Tokyo
- University of California, San Diego
- University of California, Los Angeles
- University of Chicago
- University of California, Davis
- Duke University
- Yale University
- University of Costa Rica
- University of Washington
- London School of Hygiene and Tropical Medicine
