Michael J. Pikal
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American pharmaceutical scientist
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Chemistry
Why Is Michael J. Pikal Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michael J. Pikal was an American Pharmaceutical Scientist. Pikal was born in Wadena, Minnesota on August 17, 1939 to parents Harold and Sophie. He attended Henning High School and earned a bachelor's degree in chemistry from St. John's University, then received a doctorate from Iowa State University in 1966. Pikal was an assistant professor at the University of Tennessee from 1967 to 1972. He joined Eli Lilly and Company as a senior research scientist later that year. Pikal left the company in 1996 to teach at the University of Connecticut, where he was appointed Pfizer Distinguished Endowed Chair in Pharmaceutical Technology in 2005. Pikal married Janice L. Klein, with whom he had five children. He retired in December 2017 and died at home in Mansfield Center, Connecticut, on February 26, 2018, aged 78.
Michael J. Pikal's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice (2004) (799)
- Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice (1997) (609)
- Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous state. (2008) (378)
- Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix? (2005) (376)
- Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization (2007) (374)
- Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis. (2010) (322)
- Mass and heat transfer in vial freeze-drying of pharmaceuticals: role of the vial. (1984) (307)
- CHARACTERIZATION OF THE TIME SCALES OF MOLECULAR MOTION IN PHARMACEUTICALLY IMPORTANT GLASSES (1999) (299)
- The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase (1990) (277)
- Mechanisms of protein stabilization in the solid state. (2009) (257)
- Quantitative crystallinity determinations for beta-lactam antibiotics by solution calorimetry: correlations with stability. (1978) (250)
- Determination of End Point of Primary Drying in Freeze-Drying Process Control (2010) (231)
- The role of electroosmotic flow in transdermal iontophoresis (1992) (227)
- The role of electroosmotic flow in transdermal iontophoresis. (1992) (218)
- The secondary drying stage of freeze drying: drying kinetics as a function of temperature and chamber pressure☆ (1990) (211)
- Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling (2004) (210)
- The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone (1991) (204)
- Use of laboratory data in freeze drying process design: heat and mass transfer coefficients and the computer simulation of freeze drying. (1985) (201)
- Physical chemistry of freeze-drying: measurement of sublimation rates for frozen aqueous solutions by a microbalance technique. (1983) (183)
- Apparent Molal Volumes of Some Aqueous Rare Earth Chloride and Nitrate Solutions at 25°1 (1966) (181)
- Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state. (2005) (173)
- Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals (2010) (170)
- Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect (2003) (162)
- Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization. (1997) (160)
- Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer (2005) (152)
- The challenge of drying method selection for protein pharmaceuticals: product quality implications. (2007) (147)
- Effect of Initial Buffer Composition on pH Changes During Far-From-Equilibrium Freezing of Sodium Phosphate Buffer Solutions (2004) (144)
- MECHANISMS OF PROTEIN STABILIZATION DURING FREEZE-DRYING AND STORAGE : THERELATIVE IMPORTANCE OF THERMODYNAMIC STABILIZATION AND GLASSY STATE RELAXAT ION DYNAMICS (1999) (144)
- Dynamics of pharmaceutical amorphous solids: the study of enthalpy relaxation by isothermal microcalorimetry. (2002) (138)
- Evaluation of tunable diode laser absorption spectroscopy for in-process water vapor mass flux measurements during freeze drying. (2007) (135)
- A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers (2002) (135)
- Calorimetric investigation of the structural relaxation of amorphous materials: evaluating validity of the methodologies. (2005) (133)
- The Stability of Insulin in Crystalline and Amorphous Solids: Observation of Greater Stability for the Amorphous Form (1997) (132)
- Interpretation of relaxation time constants for amorphous pharmaceutical systems. (2000) (130)
- Stabilization of proteins in solid form. (2015) (128)
- Lyophilized Drug Product Cake Appearance: What Is Acceptable? (2017) (127)
- Drying-induced variations in physico-chemical properties of amorphous pharmaceuticals and their impact on stability (I): stability of a monoclonal antibody. (2007) (123)
- Freeze‐Drying of Proteins. Process, Formulation, and Stability. (1995) (122)
- A computational model for finite element analysis of the freeze-drying process (1997) (117)
- Study of the individual contributions of ice formation and freeze-concentration on isothermal stability of lactate dehydrogenase during freezing. (2008) (112)
- Aqueous solubility of crystalline and amorphous drugs: Challenges in measurement (2011) (111)
- Process control in freeze drying: determination of the end point of sublimation drying by an electronic moisture sensor. (1989) (101)
- Solubility advantage of amorphous pharmaceuticals, part 3: Is maximum solubility advantage experimentally attainable and sustainable? (2011) (101)
- Impact of sucrose level on storage stability of proteins in freeze-dried solids: II. Correlation of aggregation rate with protein structure and molecular mobility. (2009) (100)
- Formulation and stability of freeze-dried proteins: effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone. (1992) (97)
- Transport Mechanisms in Iontophoresis. II. Electroosmotic Flow and Transference Number Measurements for Hairless Mouse Skin (1990) (96)
- Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid. (2008) (95)
- The Effect of Stabilizers and Denaturants on the Cold Denaturation Temperatures of Proteins and Implications for Freeze-Drying (2005) (92)
- Coupling Between Chemical Reactivity and Structural Relaxation in Pharmaceutical Glasses (2006) (92)
- Freeze‐Drying of Mannitol–Trehalose–Sodium Chloride‐Based Formulations: The Impact of Annealing on Dry Layer Resistance to Mass Transfer and Cake Structure (2004) (90)
- Drying-Induced Variations in Physico-Chemical Properties of Amorphous Pharmaceuticals and Their Impact on Stability II: Stability of a Vaccine (2007) (89)
- Transport Mechanisms in Iontophoresis. III. An Experimental Study of the Contributions of Electroosmotic Flow and Permeability Change in Transport of Low and High Molecular Weight Solutes (1990) (87)
- Reduced Pressure Ice Fog Technique for Controlled Ice Nucleation during Freeze-Drying (2009) (86)
- Transport Mechanisms in Iontophoresis. I. A Theoretical Model for the Effect of Electroosmotic Flow on Flux Enhancement in Transdermal Iontophoresis (1990) (85)
- Prediction of the onset of crystallization of amorphous sucrose below the calorimetric glass transition temperature from correlations with mobility. (2007) (81)
- Stability testing of pharmaceuticals by high-sensitivity isothermal calorimetry at 25°C: cephalosporins in the solid and aqueous solution states☆ (1989) (81)
- Thermal Decomposition of Amorphous β-Lactam Antibacterials (1977) (79)
- Emerging Freeze-Drying Process Development and Scale-up Issues (2011) (77)
- Choked flow and importance of Mach I in freeze-drying process design (2010) (76)
- Heat and mass transfer scale-up issues during freeze-drying, III: Control and characterization of dryer differences via operational qualification tests (2006) (76)
- Cake Shrinkage During Freeze Drying: A Combined Experimental and Theoretical Study (2005) (75)
- Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. Correlation of protein-sugar interaction with native structure preservation. (2009) (71)
- Prediction of onset of crystallization from experimental relaxation times. II. Comparison between predicted and experimental onset times. (2008) (71)
- Recommended Best Practices for Process Monitoring Instrumentation in Pharmaceutical Freeze Drying—2017 (2017) (68)
- Thermophysical Properties of Pharmaceutically Compatible Buffers at Sub-Zero Temperatures: Implications for Freeze-Drying (2002) (67)
- The Nonsteady State Modeling of Freeze Drying: In-Process Product Temperature and Moisture Content Mapping and Pharmaceutical Product Quality Applications (2005) (67)
- The impact of drying method and formulation on the physical properties and stability of methionyl human growth hormone in the amorphous solid state. (2008) (66)
- Evaluation of manometric temperature measurement (MTM), a process analytical technology tool in freeze drying, part III: Heat and mass transfer measurement (2008) (64)
- Use of manometric temperature measurement (MTM) and SMART freeze dryer technology for development of an optimized freeze-drying cycle. (2007) (62)
- Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part I, product temperature measurement (2006) (62)
- Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part II measurement of dry-layer resistance (2008) (61)
- Predictions of Onset of Crystallization from Experimental Relaxation Times I-Correlation of Molecular Mobility from Temperatures Above the Glass Transition to Temperatures Below the Glass Transition (2006) (60)
- RELATIVE VISCOSITIES OF SOME AQUEOUS RARE EARTH CHLORIDE SOLUTIONS AT 25 DEG (1966) (59)
- The effect of annealing on the stability of amorphous solids: chemical stability of freeze-dried moxalactam. (2007) (58)
- A Pragmatic Test of a Simple Calorimetric Method for Determining the Fragility of Some Amorphous Pharmaceutical Materials (1998) (58)
- Measurement of the Kinetics of Protein Unfolding in Viscous Systems and Implications for Protein Stability in Freeze-Drying (2005) (57)
- The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyrine Calcium Channel Blockers (2002) (57)
- Role of mechanical stress in crystallization and relaxation behavior of amorphous indomethacin. (2008) (56)
- Lyophilization process design space. (2013) (55)
- A procedure to optimize scale-up for the primary drying phase of lyophilization. (2009) (53)
- Prediction of onset of crystallization in amorphous pharmaceutical systems: phenobarbital, nifedipine/PVP, and phenobarbital/PVP. (2010) (52)
- Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy. (2009) (50)
- Process Analytical Technologies (PAT) in freeze-drying of parenteral products (2009) (50)
- Effect of dimethyl sulfoxide, urea, guanidine hydrochloride, and sodium chloride on hydrophobic interactions. Heats of dilution of tetrabutylammonium bromide and lithium bromide in mixed aqueous solvent systems (1972) (49)
- Addition of Amino Acids to Further Stabilize Lyophilized Sucrose-Based Protein Formulations: I. Screening of 15 Amino Acids in Two Model Proteins. (2016) (48)
- The study of phase separation in amorphous freeze-dried systems. Part I: Raman mapping and computational analysis of XRPD data in model polymer systems. (2011) (47)
- Intravial distribution of moisture during the secondary drying stage of freeze drying. (1997) (46)
- Freeze-Drying Process Development and Scale-Up: Scale-Up of Edge Vial Versus Center Vial Heat Transfer Coefficients, Kv. (2016) (45)
- Investigation of drying stresses on proteins during lyophilization: differentiation between primary and secondary-drying stresses on lactate dehydrogenase using a humidity controlled mini freeze-dryer. (2007) (45)
- Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study (2011) (44)
- Solid state chemistry of proteins: I. glass transition behavior in freeze dried disaccharide formulations of human growth hormone (hGH). (2007) (43)
- The effect of dryer load on freeze drying process design. (2010) (43)
- The impact of thermal treatment on the stability of freeze-dried amorphous pharmaceuticals: II. Aggregation in an IgG1 fusion protein. (2010) (42)
- Correlation of annealing with chemical stability in lyophilized pharmaceutical glasses. (2008) (42)
- Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples. (2014) (42)
- Moisture transfer from stopper to product and resulting stability implications. (1992) (42)
- Optimization of the Secondary Drying Step in Freeze Drying Using TDLAS Technology (2011) (41)
- Accurate prediction of collapse temperature using optical coherence tomography-based freeze-drying microscopy. (2013) (37)
- Solid state stability of proteins III: calorimetric (DSC) and spectroscopic (FTIR) characterization of thermal denaturation in freeze dried human growth hormone (hGH). (2008) (37)
- Investigation of the impact of annealing on global molecular mobility in glasses: optimization for stabilization of amorphous pharmaceuticals. (2008) (37)
- Heat and Mass Transfer in Low Pressure Gases: Applications to Freeze Drying (1999) (36)
- Ion-pair formation and the theory of mutual diffusion in a binary electrolyte (1971) (36)
- Evaluation of glassy-state dynamics from the width of the glass transition: results from theoretical simulation of differential scanning calorimetry and comparisons with experiment. (2004) (36)
- Using modulated DSC to investigate the origin of multiple thermal transitions in frozen 10% sucrose solutions (2006) (35)
- Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability (2016) (35)
- Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline. (2008) (34)
- Effect of Controlled Ice Nucleation on Stability of Lactate Dehydrogenase During Freeze-Drying. (2017) (32)
- The study of phase separation in amorphous freeze-dried systems, part 2: investigation of Raman mapping as a tool for studying amorphous phase separation in freeze-dried protein formulations. (2011) (31)
- Effect of hydration on the secondary structure of lyophilized proteins as measured by fourier transform infrared (FTIR) spectroscopy. (2007) (30)
- Characterization of dynamics in complex lyophilized formulations: II. Analysis of density variations in terms of glass dynamics and comparisons with global mobility, fast dynamics, and Positron Annihilation Lifetime Spectroscopy (PALS). (2013) (30)
- Different measures of molecular mobility: comparison between calorimetric and thermally stimulated current relaxation times below Tg and correlation with dielectric relaxation times above Tg. (2008) (29)
- The study of amorphous phase separation in a model polymer phase-separating system using Raman microscopy and a low-temperature stage: effect of cooling rate and nucleation temperature. (2011) (28)
- Impact of critical process and formulation parameters affecting in-process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: a mini freeze dryer study. (2007) (26)
- Stability of Freeze-Dried Protein Formulations: Contributions of Ice Nucleation Temperature and Residence Time in the Freeze-Concentrate. (2020) (25)
- Investigations on polyplex stability during the freezing step of lyophilization using controlled ice nucleation--the importance of residence time in the low-viscosity fluid state. (2013) (23)
- Freeze-drying in novel container system: Characterization of heat and mass transfer in glass syringes. (2010) (23)
- Optical coherence tomography-based freeze-drying microscopy (2011) (23)
- Effects of annealing on enthalpy relaxation in lyophilized disaccharide formulations: mathematical modeling of DSC curves. (2008) (22)
- Reliable determination of freeze-concentration using DSC (2005) (22)
- The effects of formulation and moisture on the stability of a freeze-dried monoclonal antibody-vinca conjugate: a test of the WLF glass transition theory. (1992) (22)
- Theory of the Onsager transport coefficients lij and Rij for electrolyte solutions (1971) (22)
- The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: I. Dimer formation in sodium ethacrynate. (2010) (22)
- Effect of Sugars on the Molecular Motion of Freeze-Dried Protein Formulations Reflected by NMR Relaxation Times (2011) (21)
- Chemistry in solid amorphous matrices: Implication for biostabilization (2002) (21)
- Chemical stability of amorphous materials: specific and general media effects in the role of water in the degradation of freeze-dried zoniporide. (2012) (21)
- A theoretical treatment of changes in energy and entropy of solids caused by additives or impurities in solid solution (1987) (20)
- Modeling the Secondary Drying Stage of Freeze Drying: Development and Validation of an Excel-Based Model. (2017) (20)
- Post-thaw aging affects activity of lactate dehydrogenase. (2005) (20)
- The glass transition and sub-T(g)-relaxation in pharmaceutical powders and dried proteins by thermally stimulated current. (2009) (20)
- High-precision absolute (true) density measurements on hygroscopic powders by gas pycnometry: application to determining effects of formulation and process on free volume of lyophilized products. (2011) (20)
- Isotope effect in tracer diffusion. Comparison of the diffusion coefficients of 24Na+ and 22Na+ in aqueous electrolytes (1972) (19)
- Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals: Water Clusters Hypothesis. (2019) (18)
- A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure. (1997) (18)
- Polymer sorption of nitroglycerin and stability of molded nitroglycerin tablets in unit-dose packaging. (1977) (18)
- Impact of Natural Variations in Freeze-Drying Parameters on Product Temperature History: Application of Quasi Steady-State Heat and Mass Transfer and Simple Statistics (2018) (17)
- Is the pre-Tg DSC endotherm observed with solid state proteins associated with the protein internal dynamics? Investigation of bovine serum albumin by solid state hydrogen/deuterium exchange. (2013) (17)
- Spatial Variation of Pressure in the Lyophilization Product Chamber Part 1: Computational Modeling (2017) (16)
- A test of the onsager reciprocal relations and a discussion of the ionic isothermal vector transport coefficientsIIj for aqueous AgNO3 at 25°C (1972) (16)
- Spatial Variation of Pressure in the Lyophilization Product Chamber Part 2: Experimental Measurements and Implications for Scale-up and Batch Uniformity (2017) (15)
- Desolvation kinetics of cefamandole sodium methanolate: the effect of water vapor (1983) (15)
- Solid state 13C NMR investigation of impact of annealing in lyophilized glasses. (2008) (15)
- Study of the Mechanisms of Flux Enhancement Through Hairless Mouse Skin by Pulsed DC Iontophoresis (1991) (14)
- Characterization of dynamics in complex lyophilized formulations: I. Comparison of relaxation times measured by isothermal calorimetry with data estimated from the width of the glass transition temperature region. (2013) (14)
- The effect of solubilization on counter ion binding to micelles (1972) (13)
- Vapor pressure of nitroglycerin in sublingual molded tablets: implications for stability. (1976) (13)
- Development of freeze-dried biosynthetic Factor VIII: I. A case study in the optimization of formulation (2009) (12)
- Determination and comparison of Hittorf and cell transference numbers for aqueous silver nitrate solutions at 25.deg. (1970) (12)
- Addition of Monovalent Electrolytes to Improve Storage Stability of Freeze-Dried Protein Formulations. (2016) (12)
- Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools. (2016) (11)
- Simultaneous measurement of water desorption isotherm and heats of water desorption of proteins using perfusion isothermal microcalorimetry. (2007) (11)
- Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis. (2013) (10)
- Solid state chemistry of proteins IV. What is the meaning of thermal denaturation in freeze dried proteins? (2009) (10)
- Optimization of a Raman microscopy technique to efficiently detect amorphous-amorphous phase separation in freeze-dried protein formulations. (2014) (9)
- IMPACT OF POLYMORPHISM ON THE QUALITY OF LYOPHILIZED PRODUCTS (1999) (9)
- Applications of the Tunable Diode Laser Absorption Spectroscopy: In-Process Estimation of Primary Drying Heterogeneity and Product Temperature During Lyophilization. (2019) (9)
- Knudsen vapor pressure measurements on pure materials and solutions dispersed in porous media: molded nitroglycerin tablets. (1976) (9)
- Tracer diffusion of HTO and simple ions in aqueous solutions of sodium p-ethylbenzene sulfonate. Comparisons with polyelectrolyte solutions and gels (1973) (8)
- Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations. (2012) (8)
- Design of a Formulation for Freeze Drying (2010) (8)
- Dynamics in Polysaccharide Glasses and Their Impact on the Stability of Encapsulated Flavors (2016) (7)
- Development of a Mini-Freeze Dryer for Material-Sparing Laboratory Processing with Representative Product Temperature History (2017) (7)
- Rubber closures as a source of haze in freeze dried parenterals: test methodology for closure evaluation. (1978) (6)
- Protein Internal Dynamics Associated With Pre-System Glass Transition Temperature Endothermic Events: Investigation of Insulin and Human Growth Hormone by Solid State Hydrogen/Deuterium Exchange. (2016) (6)
- The Freeze‐Drying Process: The Use of Mathematical Modeling in Process Design, Understanding, and Scale‐Up (2010) (6)
- Freeze Drying Properties of Some Oligonucleotides (2001) (6)
- Thermal decomposition of amorphous beta-lactam antibacterials. (1977) (6)
- Hittorf transference numbers in aqueous copper sulfate at 25.deg. (1971) (6)
- Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: part I, product temperature measurement. (2006) (4)
- Effect of nitroglycerin-soluble additives on the stability of molded nitroglycerin tablets. (1984) (3)
- Biotechnology : Pharmaceutical Aspects (2008) (3)
- APPLICABILITY OF MANOMETRIC TEMPERATURE MEASUREMENT (MTM) AND SMART ™ FREEZE DRYER TECHNOLOGY TO DEVELOPMENT OF AN OPTIMIZED FREEZE DRYING CYCLE: PRELIMINARY INVESTIGATION OF TWO AMORPHOUS SYSTEMS (2005) (3)
- Rational Design of Solid Protein Formulations (2012) (2)
- Recommended Best Practices in Freeze Dryer Equipment Performance Qualification: 2022 (2023) (2)
- Stabilization of Lyophilized Pharmaceuticals by Control of Molecular Mobility: Impact of Thermal History (2010) (2)
- Mechanisms of Protein Stabilization in the Solid State (2009) (2)
- Lyophilization of Therapeutic Proteins in Vials: Process Scale-Up and Advances in Quality by Design (2015) (2)
- SMART TM FREEZE DRYER TECHNOLOGY : IMPACT OF WATER RE-ADSORPTION OF POLYVINYLPYRROLIDONE ( PVP ) ON MANOMETRIC TEMPERATURE MEASUREMENTS ( MTM ) DURING PRIMARY DRYING (2)
- Impact of Natural Variations in Freeze-Drying Parameters on Product Temperature History: Application of Quasi Steady-State Heat and Mass Transfer and Simple Statistics (2018) (1)
- Diaphragm cell diffusion studies with short prediffusion times (1970) (1)
- Apparent molal volumes and viscosities of some aqueous rare-earth chloride solutions at 25°C (1966) (1)
- Recommended Best Practices for Process Monitoring Instrumentation in Pharmaceutical Freeze Drying—2017 (2017) (1)
- Variation in Product Temperature and Drying Time within a Lyophilized Batch during Primary Drying (2011) (1)
- Effect of water-hydrocarbon interactions on proton mobility. Chronoamperometric diffusion coefficients in aqueous tert-butyl alcohol (1974) (1)
- THE FREEZE DRYING PROCESS (2019) (1)
- Correction to: Evaluation of Predictors of Protein Relative Stability Obtained by \Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR (2020) (1)
- Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability (2016) (0)
- Stability in Glassy Pharmaceuticals: The Role of Glass Dynamics (2007) (0)
- Evaluation of a Raman Chemometric Method for Detecting Protein Structural Conformational Changes in Solution. (2022) (0)
- results of Evaluation of the lKB 2277 Calorimeter for stability testing of Pharmaceuticals (2008) (0)
- THE EFFECT OF WATER -HYDROCARBON INTERACTIONS ON PROTON MOBILITY, CHRONOAMPEROMETRIC DIFFUSION COEFFICIENTS IN AQUEOUS TERT.-BUTYL ALCOHOL (1974) (0)
- Spatial Variation of Pressure in the Lyophilization Product Chamber Part 2: Experimental Measurements and Implications for Scale-up and Batch Uniformity (2016) (0)
- Factor VIII formulations free of albumin (2000) (0)
- Correction to: Evaluation of Predictors of Protein Relative Stability Obtained by \Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR (2021) (0)
- The albumin-free Factor VIII formulation (2000) (0)
- Pharmaceutical compositions of ceftazidime. (1985) (0)
- Evaluation of Predictors of Protein Relative Stability Obtained by Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR (2020) (0)
- Development of a Mini-Freeze Dryer for Material-Sparing Laboratory Processing with Representative Product Temperature History (2017) (0)
- A process for the stabilization of disordered cefovecin sodium salt (2005) (0)
- New albumin-free factor VIII preparations (2000) (0)
- New formulations Free Albumin factor viii. (2000) (0)
- Hydrogen-bond network dynamics in sugar-based glasses (2009) (0)
- Spatial Variation of Pressure in the Lyophilization Product Chamber Part 1: Computational Modeling (2016) (0)
- PHARMACEUTICAL TECHNOLOGY Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy (2009) (0)
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