Michael J. Rogers
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British Australian musculoskeletal pharmacologist
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Engineering Computer Science
Michael J. Rogers's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Michael J. Rogers's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy (2008) (1258)
- Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras (1998) (1175)
- Cellular and molecular mechanisms of action of bisphosphonates (2000) (927)
- Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. (2001) (861)
- Bisphosphonates: from the laboratory to the clinic and back again. (1999) (831)
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. (1999) (713)
- New insights into the molecular mechanisms of action of bisphosphonates. (2003) (573)
- Molecular Mechanisms of Action of Bisphosphonates: Current Status (2006) (537)
- The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs (2006) (493)
- Bone remodelling at a glance (2011) (441)
- Biochemical and molecular mechanisms of action of bisphosphonates. (2011) (441)
- Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti‐tumour activity (1997) (427)
- Clodronate and Liposome‐Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′‐(β,γ‐Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro (1997) (393)
- Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. (2007) (387)
- Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL (2007) (367)
- Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298 (2000) (366)
- Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. (2002) (304)
- The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo (2009) (294)
- Overview of bisphosphonates (1997) (290)
- Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. (2008) (281)
- Heterocycle‐Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure‐Activity Relationships in J774 Macrophages (1998) (276)
- Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche (2015) (273)
- The pharmacology of bisphosphonates and new insights into their mechanisms of action (1999) (273)
- The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. (2001) (256)
- Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (1999) (254)
- Recent advances in understanding the mechanism of action of bisphosphonates. (2006) (246)
- Bisphosphonates: Pharmacology, Mechanisms of Action and Clinical Uses (1999) (239)
- The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. (1998) (237)
- Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. (2001) (237)
- Cytosolic Entry of Bisphosphonate Drugs Requires Acidification of Vesicles after Fluid-Phase Endocytosis (2006) (228)
- Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. (2007) (214)
- Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells. (2008) (214)
- Bisphosphonates induce apoptosis in mouse macrophage‐like cells in vitro by a nitric oxide‐independent mechanism (1996) (201)
- Statins Prevent Bisphosphonate‐Induced γ,δ‐T‐Cell Proliferation and Activation In Vitro (2003) (195)
- Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases (2006) (176)
- The Ability of Statins to Inhibit Bone Resorption Is Directly Related to Their Inhibitory Effect on HMG‐CoA Reductase Activity (2003) (173)
- Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. (2010) (172)
- Molecular mechanisms of action of bisphosphonates. (1999) (171)
- Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. (1997) (161)
- Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages* (2001) (159)
- From Molds and Macrophages to Mevalonate: A Decade of Progress in Understanding the Molecular Mode of Action of Bisphosphonates (2004) (157)
- Fluorescent Risedronate Analogues Reveal Bisphosphonate Uptake by Bone Marrow Monocytes and Localization Around Osteocytes In Vivo (2009) (151)
- Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. (2008) (144)
- Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells (2007) (141)
- The regulation of osteoclast function and bone resorption by small GTPases (2011) (131)
- Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer. (2015) (120)
- Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes. (1996) (118)
- The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation (2010) (116)
- Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. (2001) (115)
- Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (2021) (112)
- Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite. (1999) (109)
- Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum. (1994) (107)
- Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption (2002) (106)
- Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. (2004) (102)
- The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast Function (2002) (102)
- Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo (2012) (99)
- Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo. (2005) (97)
- Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry. (1997) (97)
- Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway (2006) (93)
- The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. (2012) (85)
- Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. (1998) (85)
- Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro. (1998) (83)
- The Molecular Mechanisms of Action of Bisphosphonates (2007) (83)
- Antagonistic Effects of Different Classes of Bisphosphonates in Osteoclasts and Macrophages In Vitro (2003) (81)
- Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae. (1995) (73)
- Metabolism of halogenated bisphosphonates by the cellular slime mould Dictyostelium discoideum. (1992) (72)
- Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold dictyostelium discoideum (1994) (67)
- Statins: lower lipids and better bones? (2000) (65)
- Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma (2002) (65)
- The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. (2009) (65)
- Activation of γδ T cells by bisphosphonates. (2010) (61)
- A Comparison between the Effects of Hydrophobic and Hydrophilic Statins on Osteoclast Function In Vitro and Ovariectomy-Induced Bone Loss In Vivo (2007) (58)
- Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. (2010) (57)
- Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. (2002) (55)
- Molecular mechanisms of actions of bisphosphonates and new insights into their effects outside the skeleton. (2020) (54)
- Fluorescently labeled risedronate and related analogues: "magic linker" synthesis. (2008) (53)
- Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase* (2009) (53)
- The Matricellular Protein CYR61 Inhibits Osteoclastogenesis by a Mechanism Independent of αvβ3 and αvβ5 (2007) (50)
- RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro (2009) (49)
- Osteoclasts on Bone and Dentin In Vitro: Mechanism of Trail Formation and Comparison of Resorption Behavior (2013) (47)
- A Class III Semaphorin (Sema3e) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro (2012) (47)
- Inhibition of Growth of Dictyostelium discoideum Amoebae by Bisphosphonate Drugs Is Dependent on Cellular Uptake (1997) (46)
- Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo. (2008) (41)
- The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. (2012) (40)
- Oxysterols: From physiological tuners to pharmacological opportunities (2020) (40)
- The Cellular Uptake and Metabolism of Clodronate in RAW 264 Macrophages (2001) (37)
- Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. (2006) (36)
- Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts. (2010) (36)
- Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (2021) (35)
- Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase (2005) (34)
- Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry. (2000) (33)
- The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5. (2007) (32)
- Osteoglycin, a novel coordinator of bone and glucose homeostasis (2018) (32)
- The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma (2000) (31)
- Signal peptide mutations in RANK prevent downstream activation of NF-κB (2011) (31)
- Advances in Treating Metastatic Bone Cancer: Summary Statement for the First Cambridge Conference (2006) (29)
- Activation of gammadelta T Cells by Bisphosphonates (2010) (29)
- Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases (2016) (28)
- Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function (2011) (28)
- Anti-tumour activity of bisphosphonates in human myeloma cells. (1998) (27)
- BisphosphonatesMechanisms of Action (2002) (26)
- A Novel Method for Efficient Generation of Transfected Human Osteoclasts (2007) (25)
- A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton (2015) (25)
- Bisphosphonates--mechanisms of action in multiple myeloma. (2000) (25)
- Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women. (2009) (24)
- Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency. (2017) (23)
- Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. (2011) (22)
- Epidermal growth factor receptors and oestrogen receptors in the head and neck. (1993) (17)
- Synthesis and Characterization of Novel Fluorescent Nitrogen-Containing Bisphosphonate Imaging Probes for Bone Active Drugs (2011) (16)
- Isolation and purification of rabbit osteoclasts. (2012) (13)
- Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency (2019) (13)
- The expression of somatostatin receptors 1 and 2 in benign, pre-malignant and malignant laryngeal lesions. (2003) (13)
- The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma. (2000) (12)
- Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes. (2019) (12)
- Introduction to bisphosphonates and the clinical pharmacology of alendronate (1997) (12)
- Cytosolic entry of bisphosphonate drugs requires acidification of vesicles following fluid-phase endocytosis (2006) (11)
- Bisphosphonates and [gamma][delta] t-cells: New insights into old drugs (2006) (11)
- Nitrogen‐Containing Biphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras (2005) (10)
- Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. (2014) (10)
- The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas (2004) (10)
- JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). (2005) (9)
- Resorbing osteoclasts increase the availability of mineral-bound bisphosphonates to non-resorbing cells (2006) (8)
- Chapter 78 – Bisphosphonates: Mechanisms of Action (2002) (8)
- Apomine Enhances the Antitumor Effects of Lovastatin on Myeloma Cells by Down-Regulating 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase (2007) (8)
- The mechanism of inhibition of farnesyl diphosphate synthase by nitrogen-containing bisphosphonates (2002) (7)
- The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. (2011) (7)
- Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo (2008) (7)
- Application of phosphonate and thiophosphate analogues of nucleotides to studies of some enzyme reactions (1991) (6)
- Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates (2006) (6)
- Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease? (2015) (6)
- Melphalan modifies the bone microenvironment by enhancing osteoclast formation (2017) (5)
- HIV treatments and the skeleton: Do NRTIs directly effect bone cells? (2010) (5)
- Chapter 81 – Bisphosphonates: Mechanisms of Action (2008) (5)
- From vesicle to cytosol (2018) (5)
- Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages (2021) (5)
- Effects of Bisphosphonates on the Inflammatory Processes of Activated Macrophages (1999) (5)
- Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates (2007) (4)
- Modeling of bisphosphonate binding to farnesyl diphosphate synthase (2002) (4)
- Isolation and purification of rabbit osteoclasts. (2003) (4)
- Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates. (2005) (4)
- Intravital imaging of osteoclasts in vivo reveals novel osteoclast fate which may underlie the therapeutic response to Denosumab withdrawal (2019) (4)
- Pathways of bisphosphonate-induced apoptosis in murine macrophage-like cells (1995) (4)
- In vitro time- and dose-effect response of JP-8 and S-8 jet fuel on alveolar type II epithelial cells of rats (2010) (4)
- Intravital imaging of osteoclasts in vivo reveals cellular recycling as a novel cell fate mechanism. (2017) (3)
- Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications (2021) (3)
- A Class III Semaphorin (Sema3e) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro (2012) (3)
- Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption (1996) (3)
- Cellular and molecular actions of bisphosphonates (2015) (3)
- THEMED ISSUE: CANNABINOIDS RESEARCH PAPER A role for L-a-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells (2010) (3)
- Melphalan modifies the bone microenvironment by enhancing osteoclast formation. (2017) (3)
- Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase (2008) (2)
- The Ability of Bisphosphonates and Their Analogues to Penetrate the Osteocyte Network is Dependent on Affinity for Bone (2010) (2)
- Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo (2009) (2)
- New insights into the molecular actions of nitrogen-containing bisphosphonates (2009) (2)
- Bacterial Protein Toxins: Bacterial toxins and bone remodelling (2005) (2)
- The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces (2009) (2)
- Functional interaction between Sequestosome-1 / p 62 and Autophagy-Linked FYVE-containing protein WDFY 3 in human osteoclasts Running title : SQSTM 1 and ALFY in human osteoclasts (2011) (2)
- Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition. (2006) (2)
- 79.Synergistic effect of Apomine and Lovastatin on osteosarcoma cell growth in vitro and in vivo (2010) (1)
- GPR55: A novel cannabinoid receptor involved in the regulation of osteoclast function and bone mass (2009) (1)
- Polymorphic variation in the FPP synthase (FPPS) gene and effects on bisphosphonate inhibition (2007) (1)
- Clinical and translational pharmacology of bisphosphonates (2019) (1)
- Upregulation of endogenous FPP synthase in cultured cells causes resistance to bisphosphonate (2011) (1)
- Bacterial protein toxins : role in the interference with cell-growth regulation (2005) (1)
- Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase (2008) (1)
- P71. The effects of bisphosphonates and their phosphinic acid analogues on bone resorption and on growth of Dictyostelium amoebae (1994) (1)
- Brief report Alkylamines cause V (cid:1) 9V (cid:2) 2 T-cell activation and proliferation by inhibiting the mevalonate pathway (2005) (1)
- Intracellular uptake of bisphosphonates by the slime mould dictyostelium discoideum (1992) (1)
- Studies to elucidate the anti-tumor mechanism of action of risedronate in human myeloma cells; Use of an analogue of risedronate reveals the effects of differential inhibition of prenylation (2005) (1)
- Forum in Bone and Mineral Research 6th Meeting Napoli (2009) (1)
- Nitrogen-containing bisphosphonates and alkylamines activate Vγ9Vδ2 T cells through a common mechanism involving inhibition of the mevalonate pathway (2006) (1)
- Preclinical abstracts45Prevention of breast cancer cell adhesion to bone in vitro by bisphosphonates is mediated by their inhibitory effect on protein prenylation (2006) (1)
- Bone anabolic effects of statins (2000) (1)
- Alkylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway (2006) (1)
- Identification of a bisphosphonate which inhibits FPP synthase and IPP isomerase (2001) (1)
- THE ANTI-RESORPTIVE DRUG CLODRONATE IS METABOLISED TO A NON-HYDROLYSABLE ATP ANALOGUE BY MAMMALIAN CELLS IN VITRO (1996) (1)
- P69. Inhibition of growth of Dictyostelium discoideum by bisphosphonates is dependent on the bisphosphonates being taken up by pinocytosis (1994) (1)
- Mechanisms of Action of Bisphosphonates (2006) (1)
- Bisphosphonates (2007) (0)
- Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates (2006) (0)
- MOLECULAR STUDIES OF APOPTOSIS INDUCED BY ANTI-RESORPTIVE BISPHOSPHONATE DRUGS (1996) (0)
- Cytosolic entry of Bisphosphonates into macrophages and osteoclasts requires fluid-phase endocytosis and endosomal acidification (2006) (0)
- Novel insights into the anti-tumour mechanism of action of apomine and its synergistic interaction with lovastatin in myeloma cells in vitro (2006) (0)
- Functional analysis of mutations in rank that result in diseases with opposite phenotypes (2009) (0)
- Anti-HIV treatments and the skeleton: NRTIS directly affect osteoblasts in vitro (2010) (0)
- A mutation that prevents rank trimer formation does not prevent signalling downstream of rank (2010) (0)
- Bisphosphonates induce apoptosis in mouse macrophage-like cells by a mechanism that does not involve changes in the level of nitric oxide or p53 (1995) (0)
- Modulation of MAPK signalling and Rho GTPase activation in osteoclasts by Pasteurella Multocida toxin (PMT) results in differential effects on differentiation and activation of murine and human osteoclasts (2005) (0)
- Loss of the cannabinoid receptor CB2 alters the mechanical but not the material properties of bone (2010) (0)
- Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency (2022) (0)
- Music to Her Ears? Male Mice Sing an Ultrasonic Tune (2005) (0)
- MEETING REPORTS Meeting Report from the 2nd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society (2006) (0)
- Why do some patients fail to respond to bisphosphonate therapy: Identification of a novel polymorphism in exon 11 of FPP synthase (2007) (0)
- BISPHOSPHONATES INHIBIT GLUCOCORTICOID INDUCED DEATH IN OSTEOCYTES (2003) (0)
- Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts (2001) (0)
- Bisphosphonates prevent osteocyte apoptosis (1999) (0)
- Overexpression of somatostatin receptors 1 and 5, and VEGF and its receptors FLK and FLT in laryngeal carcinoma: Potential targets for anti-tumoral therapy? (2003) (0)
- Bisphosphonates induce apoptosis in murine macrophage-like cells (1995) (0)
- Risedronate, and its phosphonocarboxylate analogue NE10790, both induce apoptosis, but have differential effects on the cell cycle and protein prenylation in human myeloma cells. (2004) (0)
- Osteoclasts on bone and dentin in vitro: Mechanism of degradation and comparison of resorption behaviour (2012) (0)
- Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase (2006) (0)
- Inhibition of protein prenylation by risedronate causes activation of Rac and PAK. (2002) (0)
- The subcellular localisation of feo-rank is altered when co-expressed with wildtype rank protein in vitro (2007) (0)
- Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro (2008) (0)
- Zoledronate Exerts Direct Antiproliferative and Apoptotic Effects on Human Myeloma Cells In Vitro and In Vivo . (2005) (0)
- P053Synergistic effect of apomine and lovastatin on osteosarcoma cell growth (2009) (0)
- Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes (2008) (0)
- The small GTPase Rab14 is required for osteoclast polarisation and bone resorption (2010) (0)
- the mevalonate pathway 2 T-cell activation and proliferation by inhibiting δ 9V γ Alkylamines cause V (2013) (0)
- Oral abstracts 7: Molecular mechanisms of disease—osteoarthritisS1. Identification of novel osteoarthritis genes using zebrafish (2012) (0)
- Inhibition of post-translational prenylation causes sustained activation of RAC, Cdc42 and Rho GTPases (2006) (0)
- Zoledronic Acid Inhibits Protein Prenylation in Plasmacytoma Tumors In Vivo and Enhances Survival in the INA-6 SCID Mouse Model. (2004) (0)
- Assessment of signalling downstream of the mutant rank protein that causes familial expansile osteolysis (2011) (0)
- List of Contributors (2020) (0)
- Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates. (2006) (0)
- Activation of the Rho-GTPase by Pasteurella Multocida toxin (PMT) in osteoclasts reveals contrasting roles in differentiation and activation (2004) (0)
- Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates (2008) (0)
- Inhibition by bisphosphonates of growth of a wild type and resistant strain of the slime mould dictyostelium discoideum (1992) (0)
- Nitrogen-containing bisphosphonates induce apoptosis in human bone marrow-derived myeloma cells in vitro by inhibiting protein prenylation. (1999) (0)
- Metabolism of bisphosphonates by the slime mould dictyostelium discoideum (1992) (0)
- P70. Inhibition by bisphosphonates of mammalian aminoacyl-tRNA synthetase enzymes (1994) (0)
- To the Editorial Board of BONE (2002) (0)
- Characterisation of the inhibition of rab prenylation by phosphonocarboxylates (2008) (0)
- Bisphosphonates: molecular mode of action and adverse effects (2007) (0)
- Author response: Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages (2021) (0)
- Abstract LB-159: Bisphosphonates are internalised by myeloid derived suppressor cells (MDSCs) in vivo in a mouse model of breast cancer (2011) (0)
- Meeting report from what is new in bisphosphonates: Sixth workshop on bisphosphonates (2002) (0)
- Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase (2006) (0)
- Expression, activation and regulation of the small GTPase Rap1 in bone cells (2010) (0)
- Bisphosphonates and Bone Cells—Molecular Mechanisms (2020) (0)
- Abstracts of the 4th European Laryngological Society Meeting, Brussels, 5-7 September 2002, Part I (2002) (0)
- MAPK signalling and Rho GTPase activation are perturbed by Pasteurella multocida toxin (PMT) during differentiation of murine and human osteoclasts (2005) (0)
- Discovery of a novel inhibitor of RAB geranylgeranyl transferase that inhibits bone resorption by selectively preventing prenylation of RAB proteins in osteoclasts (2001) (0)
- Activation of Rac and p38 is not related to resistance of tumour cells to bisphosphonate-induced apoptosis. (2003) (0)
- Explorer A Class III Semaphorin ( Sema 3 e ) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro (2017) (0)
- Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates (2002) (0)
- Liposome-encapsulated bisphosphonates are more potent growth inhibitors of Dictyosteuum amoebae than free bisphosphonates (1995) (0)
- Farnesyl diphosphate synthase is the target of nitrogen-containg bisphosphonates: Evidence from structure-activity relationships. (2000) (0)
- P2. Growth inhibitory effects of bisphosphonates on the slime mould dictyostelinm discoideum (1992) (0)
- Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake (2008) (0)
- Structure activity relationships of bisphosphonate analogues (2006) (0)
- Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs). (2002) (0)
- Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages (2021) (0)
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