Michael K. Rosen

Michael K. Rosen's AcademicInfluence.com Rankings

Michael K. Rosen

Physics

#6816

World Rank

#8802

Historical Rank

#1778

USA Rank

Biophysics

#288

World Rank

#300

Historical Rank

#50

USA Rank

physics Degrees

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Physics

Michael K. Rosen's Degrees

PhD Biophysics Stanford University

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Michael K. Rosen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Biomolecular condensates: organizers of cellular biochemistry (2017) (2725)
Phase Transitions in the Assembly of Multi-Valent Signaling Proteins (2012) (1566)
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins. (2015) (1107)
Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein (2000) (758)
Phase separation of signaling molecules promotes T cell receptor signal transduction (2016) (728)
Compositional Control of Phase-Separated Cellular Bodies (2016) (698)
Organization of Chromatin by Intrinsic and Regulated Phase Separation (2019) (498)
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. (2016) (485)
Structure and Control of the Actin Regulatory WAVE Complex (2010) (420)
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia (2001) (411)
Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation (2000) (401)
Phase transitions of multivalent proteins can promote clustering of membrane receptors (2014) (366)
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain (2005) (359)
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins (2017) (338)
Breaking the phonon bottleneck in nanometer quantum dots: Role of Auger-like processes (1995) (318)
Solution structure of the SH3 domain of Src and identification of its ligand-binding site. (1992) (315)
Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein (1999) (309)
Selective methyl group protonation of perdeuterated proteins. (1996) (273)
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins (2019) (257)
A framework for understanding the functions of biomolecular condensates across scales (2020) (249)
Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR. (1997) (247)
Structural basis of Rho GTPase-mediated activation of the formin mDia1. (2005) (243)
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton (2014) (235)
Physical mechanisms of signal integration by WASP family proteins. (2010) (227)
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites (2018) (223)
Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination (2013) (209)
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs (2017) (207)
Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly (2018) (205)
WASH and WAVE actin regulators of the Wiskott–Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes (2010) (198)
Arp2/3 complex is bound and activated by two WASP proteins (2011) (191)
Hierarchical regulation of WASP/WAVE proteins. (2008) (190)
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. (2003) (186)
Who's In and Who's Out-Compositional Control of Biomolecular Condensates. (2018) (185)
Rationally improving LOV domain–based photoswitches (2010) (181)
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation (2004) (180)
Structure of Cdc42 in a complex with the GTPase‐binding domain of the cell polarity protein, Par6 (2003) (180)
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. (2001) (179)
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases (1997) (167)
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer (2012) (166)
Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate. (1990) (166)
The WAVE Regulatory Complex is Inhibited (2009) (160)
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex (2003) (160)
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation (2014) (157)
Itk Functions to Control Actin Polymerization at the Immune Synapse through Localized Activation of Cdc42 and WASP (2003) (154)
Regulation of Transmembrane Signaling by Phase Separation. (2019) (152)
Arp2/3-independent assembly of actin by Vibrio type III effector VopL (2007) (152)
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLα and mDia1 (2006) (141)
Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck (2015) (140)
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 (2010) (140)
Direct demonstration of an intramolecular SH2—phosphotyrosine interaction in the Crk protein (1995) (138)
Structure and mutagenesis of the Dbl homology domain (1998) (137)
Local F-actin Network Links Synapse Formation and Axon Branching (2014) (133)
Natural Products as Probes of Cellular Function: Studies of Immunophilins (1992) (125)
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspFU during pedestal formation (2009) (120)
Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites (2017) (120)
Estimation of the available free energy in a LOV2-J alpha photoswitch. (2008) (119)
Signal transduction pathway of TonB-dependent transporters (2007) (107)
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU (2008) (105)
Data publication with the structural biology data grid supports live analysis (2016) (103)
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway (2008) (102)
Internal dynamics control activation and activity of the autoinhibited Vav DH domain (2008) (100)
Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation (2013) (100)
Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton (2014) (95)
Protein-tyrosine Kinase and GTPase Signals Cooperate to Phosphorylate and Activate Wiskott-Aldrich Syndrome Protein (WASP)/Neuronal WASP* (2006) (93)
A large kindred with X‐linked neutropenia with an I294T mutation of the Wiskott‐Aldrich syndrome gene (2009) (92)
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment (2021) (81)
A composite FKBP12-FK506 surface that contacts calcineurin (1993) (80)
An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in otherwise deuterated 15N, 13C-labeled proteins (1996) (71)
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 (2016) (69)
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes (2010) (67)
Measurement and analysis of in vitro actin polymerization. (2013) (64)
A composition-dependent molecular clutch between T cell signaling condensates and actin (2018) (62)
A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting. (2004) (62)
Repetitive N-WASP–Binding Elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly (2008) (58)
Immunophilin-ligand complexes as probes of intracellular signaling pathways. (1991) (58)
Mechanism of Actin Filament Nucleation by the Bacterial Effector VopL (2011) (58)
Specific Patterns of Cdc42 Activity Are Related to Distinct Elements of T Cell Polarization1 (2006) (56)
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein. (2005) (56)
Sequential assignment and structure determination of spider toxin omega-Aga-IVB. (1993) (56)
1H and 15N assignments and secondary structure of the Src SH3 domain (1993) (54)
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. (2003) (53)
Uncoupling Kapβ2 Substrate Dissociation and Ran Binding (2002) (51)
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein (2020) (50)
A Potential SH3 Domain-binding Site in the Crk SH2 Domain* (1996) (49)
A novel mechanism of actin filament processive capping by formin (2005) (49)
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity (2020) (48)
Crystal Structure of the Formin mDia1 in Autoinhibited Conformation (2010) (47)
Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation (2016) (47)
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. (2005) (45)
Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris (2015) (44)
The Bacterial Effector VopL Organizes Actin into Filament-like Structures (2013) (44)
Activation of an inactive immunophilin by mutagenesis (1993) (42)
Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster (2016) (41)
Molecular Recognition of Immunophilins and Immunophilin-Ligand Complexes (1992) (39)
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. (2010) (38)
ATP controls the crowd (2017) (38)
Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. (1991) (37)
Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. (2005) (32)
FK506 and rapamycin binding to FKBP: common elements in immunophilin-ligand complexation (1991) (28)
Karyopherins and condensates. (2020) (27)
A quantitative inventory of yeast P body proteins reveals principles of compositional specificity (2018) (26)
Uncoupling Kapbeta2 substrate dissociation and ran binding. (2002) (25)
Inhibition of CRISPR-Cas12a DNA targeting by nucleosomes and chromatin (2020) (23)
Enlightening molecular mechanisms through study of protein interactions. (2012) (23)
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange. (2001) (23)
Phosphorylation of nephrin induces phase separated domains that move through actomyosin contraction (2019) (22)
NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex. (2003) (22)
Reconstitution of TCR Signaling Using Supported Lipid Bilayers. (2017) (22)
NMR detection of side chain–side chain hydrogen bonding interactions in 13C/15N-labeled proteins (2000) (21)
Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation. (2017) (21)
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation (2022) (20)
Biochemical properties and inhibitors of (N-)WASP. (2006) (18)
Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation (2019) (18)
Estimation of Available Free Energy in a LOV2-Jα Photoswitch (2008) (17)
Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices. (1999) (17)
The role of sigma-1 receptor in organization of endoplasmic reticulum signaling microdomains (2020) (17)
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation (2014) (16)
Structure-function properties in disordered condensates (2020) (15)
A mitotic chromatin phase transition prevents perforation by microtubules (2022) (15)
Detection of very weak side chain–main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity-enhanced NMR spectroscopy (2000) (14)
The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains (2021) (14)
Phase Separation Can Increase Enzyme Activity by Concentration and Molecular Organization (2020) (13)
Biochemical reconstitution of the WAVE regulatory complex. (2014) (13)
Purification of native Arp2/3 complex from bovine thymus. (2013) (13)
The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements (2011) (12)
The Haemophilus ducreyi LspA1 Protein Inhibits Phagocytosis By Using a New Mechanism Involving Activation of C-Terminal Src Kinase (2014) (12)
Coupling of protein condensates to ordered lipid domains determines functional membrane organization (2022) (11)
Purification of Arp2/3 complex from Saccharomyces cerevisiae. (2013) (10)
Flipping a Switch (2001) (9)
Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris (2019) (8)
Ignition of a cellular machine (2002) (7)
The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions (1992) (6)
Generation and cycloaddition of semi-stabilized 2-azaallyllithiums via electrocyclic ring-opening or cycloreversion reactions (2002) (6)
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity (2021) (5)
Using quantitative reconstitution to investigate multicomponent condensates (2021) (5)
A chromatin phase transition protects mitotic chromosomes against microtubule perforation (2021) (5)
Study of receptor-ligand interactions through receptor labeling and isotope-edited NMR (1991) (4)
Quantitative reconstitution of yeast RNA processing bodies (2022) (4)
Correction to Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation, [Journal of Cell Biology, 212, 5, (2016), 591-603] DOI: 10.1083/jcb.201508081 (2016) (4)
In diverse conditions, intrinsic chromatin condensates have liquid-like material properties (2021) (3)
Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly (2017) (3)
Abstract A087: Phase separation of signaling molecules promotes T cell receptor signal transduction (2016) (3)
Author response: Phase transitions of multivalent proteins can promote clustering of membrane receptors (2014) (2)
Bound nucleotide can control the dynamic architecture of monomeric actin (2022) (2)
Correction: Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation (2016) (2)
Mechanistic studies of affinity modulation (2000) (2)
The mechanisms of dynamin-actin interaction (2019) (2)
[Structure and function of Formin homology 2 domain]. (2005) (2)
Author response: Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation (2021) (2)
Structural biology. Flipping a switch. (2001) (1)
Author response: A quantitative inventory of yeast P body proteins reveals principles of composition and specificity (2020) (1)
Analyzing the function of constitutively activated WASP in hematopoietic cells employing a transplanation model (2006) (1)
Phase Separation of Multi-Valent Signaling Proteins (2014) (1)
Magneto-optical Study of CdSe Quantum Dots (1998) (1)
X-linked neutopenia with a 1294T mutation of the Wiskott-Aldrich Syndrome protein (2007) (1)
X-Linked Neutropenia with a I294T Mutation of the Wiskott-Aldrich Syndrome Gene. (2006) (1)
Small Molecule Properties Define Partitioning into Biomolecular Condensates (2022) (1)
STRUCTURE OF RHOGDI: A C-TERMINAL BINDING DOMAIN TARGETS AN N-TERMINAL INHIBITORY PEPTIDE TO GTPASES, NMR, 20 STRUCTURES (1997) (0)
A framework for understanding functions of biomolecular condensates on molecular to cellular scales (2021) (0)
Author response: Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation (2013) (0)
NMR Detection of Hydrogen Bonds in Proteins and Nucleic Acids (2000) (0)
Actin Regulation by WASP and WAVE (2007) (0)
Beth Levine M.D. Prize in Autophagy Research (2021) (0)
Report and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS 35 ( D 620 N ) Mutation (0)
X-Ray Diffraction data from human WAVE Regulatory Complex (WRC) bound to a WIRS peptide from Protocadherin-10, source of 4N78 structure (2015) (0)
Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris (2016) (0)
SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP (1999) (0)
Abstract B169: Engineering phase separation of multivalent signaling proteins through the solubility of folded protein domains (2019) (0)
Coarse Grain Models Highlight the Importance of Flexible Disordered Linkers as Determinants of the Phase Behavior in Polyvalent Proteins (2014) (0)
SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP (2000) (0)
Abstract B101: Mechanism of T cell activation by phase separation (2016) (0)
Reconstitution and biochemical characterization of WAVE regulatory complex (2007) (0)
X-Ray Diffraction data from bacterial effector vopL in complex with actin, source of 4M63 structure (2015) (0)
Synergistic Phase Separation of Two Pathways Promotes Integrin Clustering and Integrin Adhesion Complex Formation (2021) (0)
Author response: The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains (2021) (0)
Stoichiometry Distribution of the Nephrin / Nck / WASP Signalsome (2008) (0)
Lit‐structure in the dark: conformational dynamics of phototropin LOV2 domain by relaxation NMR (2007) (0)
Binding Affinity Effects on Physical Characteristics of a Model Phase-Separated Protein Droplet (2015) (0)
Crystal structure of VopL C terminal domain (2011) (0)
Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
Mutual regulation between membrane rafts and protein condensates in T cell activation. (2023) (0)
Bni1p Formin Homology 2 Domain complexed with ATP-actin (2005) (0)
Coupling between Cytoplasmic Protein Phase Separation and Cholesterol-Rich Domains in the Plasma Membrane Facilitates T Cell Activation (2020) (0)
Autoinhibited Formin mDia1 Structure (2010) (0)
The Luminescence of CdSe Quantum Dots: Implication of the Band Edge Exciton Model (1996) (0)
A mitotic chromatin phase transition prevents perforation by microtubules (2022) (0)
StructureofCdc 42 incomplex with theGTPase-binding domainofthe ‘ Wiskott – Aldrich syndrome ’ protein (0)
MD Simulations of Intrinsically Disordered Proteins with Replica-Averaged Chemical Shift Restraints (2014) (0)
Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector (2008) (0)
Natural Products as a Probe of Cellular Functions: Studies of Immunophilins (2010) (0)
Mutual regulation between coupled ordered domains and protein condensates (2022) (0)
A model for chromatin organization through liquid-liquid phase separation (2022) (0)
Quantitative Analysis of Cortical Actin-Membrane Microcluster Interactions (2016) (0)
1 1 2 Intrinsically disordered regions contribute promiscuous 3 interactions to RNP granule assembly 4 5 6 7 8 9 (2017) (0)
Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris (2016) (0)
Differential LAT Microcluster Composition and ACTIN-Dependent Movement at the Immunological Synapse Center (2018) (0)
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor (2004) (0)
Structural and Biochemical Studies on PACSIN (2007) (0)
PNAS Plus Significance Statements (2015) (0)
DBL homology domain from beta-PIX (1999) (0)
A framework for understanding the functions of biomolecular condensates across scales (2020) (0)
Abacteriophageencodinga pathogenicity island , a type-IV pilusandaphage receptor incholerabacteria (1999) (0)
Coupling between protein condensates and ordered membrane domains facilitate T cell activation (2022) (0)
Development of a Chemical‐ and Photo‐Switchable Wiskott‐Aldrich Syndrome Protein (0)
Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories (2022) (0)
Mutual regulation between coupled protein condensates and ordered membrane domains. (2023) (0)
NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN (2000) (0)
Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter FecA from Escherichia coli. (2006) (0)
Structure Elucidation of the Rho-GTPhase Activating DH-Homology Domain (2000) (0)
PolarizationRelated to Distinct Elements of T Cell Specific Patterns of Cdc42 Activity Are (2006) (0)
Heating the nuclear spin system in optically pumped single GaAs quantum dots (2001) (0)
Roles of Two Energetically Coupled Dynamic Processes in the Vav Guanine Nucleotide Exchange Factor (2007) (0)
A role for Wiskott-Aldrich Syndrome protein in NK cell transcriptional activation of immune function genes but not in cytotoxic effector function (2003) (0)
( ) charge density promote phase separation d Disordered regions with NICD-like sequence features are common in human proteome (2016) (0)
Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein (2009) (0)
A Comment on Noel Malcolm, Human Rights (2020) (0)
Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter PupA from Pseudomonas putida. (2006) (0)
STRUCTURE OF RHOGDI: A C-TERMINAL BINDING DOMAIN TARGETS AN N-TERMINAL INHIBITORY PEPTIDE TO GTPASES, NMR, MINIMIZED AVERAGE STRUCTURE (1997) (0)
Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris (2015) (0)
Mechanism of WASP activation by EspFu (2007) (0)
Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1 (2005) (0)

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What Schools Are Affiliated With Michael K. Rosen?

Michael K. Rosen is affiliated with the following schools:

University of Oxford
University of Regensburg
University of Michigan
Stanford University
Case Western Reserve University
University of Toronto
University of Texas Southwestern Medical Center
Harvard University