Michael Karin

Q: What Schools Are Affiliated With Michael Karin

Michael Karin is affiliated with the following schools: MD Anderson Cancer Center, Newcastle University, University of California, San Diego, University of California, Los Angeles, Tel Aviv University, University of Chicago, University of Copenhagen, University of Ferrara, University of Duisburg-Essen

Michael Karin's AcademicInfluence.com Rankings

Michael Karin

Biology

#375

World Rank

#672

Historical Rank

#221

USA Rank

Molecular Biology

#24

World Rank

#24

Historical Rank

#15

USA Rank

biology Degrees

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Biology

Why Is Michael Karin Influential?

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According to Wikipedia, Michael Karin is an Israeli-American Distinguished Professor of Pharmacology, Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases, and American Cancer Society Research Professor at the University of California, San Diego.

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Michael Karin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Immunity, Inflammation, and Cancer (2010) (8640)
Mammalian MAP kinase signalling cascades (2001) (5133)
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. (2000) (4820)
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. (1997) (4674)
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. (1991) (3338)
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain (1994) (3331)
A central role for JNK in obesity and insulin resistance (2002) (3235)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
Missing Pieces in the NF-κB Puzzle (2002) (3050)
AP-1 function and regulation. (1997) (2857)
AP-1 as a regulator of cell life and death (2002) (2686)
Nuclear factor-κB in cancer development and progression (2006) (2638)
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor (1987) (2591)
NF-κB at the crossroads of life and death (2002) (2566)
Regulation and function of NF-kappaB transcription factors in the immune system. (2009) (2482)
NF-κB in cancer: from innocent bystander to major culprit (2002) (2366)
The two NF-κB activation pathways and their role in innate and adaptive immunity (2004) (2316)
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*) (1995) (2245)
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis (1995) (2161)
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB (1997) (2109)
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death (1996) (2107)
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ (2001) (1955)
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. (1993) (1953)
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. (2009) (1888)
Nuclear factor-kappaB in cancer development and progression. (2006) (1842)
A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007) (1833)
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer (2004) (1782)
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases (2005) (1756)
Inflammation and colon cancer. (2010) (1750)
NF-κB: linking inflammation and immunity to cancer development and progression (2005) (1748)
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production (2007) (1736)
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation (1997) (1735)
AP-1 in cell proliferation and survival (2001) (1689)
Signal transduction by tumor necrosis factor and its relatives. (2001) (1666)
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression (2010) (1570)
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs (1995) (1566)
Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction (1990) (1509)
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase (2000) (1415)
NF-kappaB: linking inflammation and immunity to cancer development and progression. (2005) (1386)
NF-κB, inflammation, immunity and cancer: coming of age (2018) (1363)
Regulation and Function of IKK and IKK-Related Kinases (2006) (1295)
NF-kappaB at the crossroads of life and death. (2002) (1284)
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway (2001) (1275)
A method for isolation of intact, translationally active ribonucleic acid. (1983) (1266)
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α (2008) (1265)
Inflammation meets cancer, with NF-κB as the matchmaker (2011) (1226)
The c-fos protein interacts with c-Jun AP-1 to stimulate transcription of AP-1 responsive genes (1988) (1221)
The regulation of transcription by phosphorylation (1992) (1206)
Intracellular pattern recognition receptors in the host response (2006) (1191)
NF-kappaB in cancer: from innocent bystander to major culprit. (2002) (1182)
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis (2005) (1169)
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity (2008) (1154)
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. (1994) (1148)
NF‐κB and the link between inflammation and cancer (2012) (1145)
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP (1987) (1145)
The two NF-kappaB activation pathways and their role in innate and adaptive immunity. (2004) (1129)
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1 (1988) (1124)
Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors (1996) (1118)
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth (2012) (1060)
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis (2009) (1008)
JNK is involved in signal integration during costimulation of T lymphocytes (1994) (1000)
IKK-β links inflammation to obesity-induced insulin resistance (2005) (990)
The IKK NF-κB system: a treasure trove for drug development (2004) (969)
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. (2010) (969)
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer (2006) (953)
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 (2006) (948)
The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis (1999) (945)
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. (1995) (927)
IKK-beta links inflammation to obesity-induced insulin resistance. (2005) (925)
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity (1991) (922)
AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs (2001) (916)
p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes (1994) (905)
Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009) (896)
The mammalian ultraviolet response is triggered by activation of src tyrosine kinases (1992) (880)
NF-κB and STAT3 – key players in liver inflammation and cancer (2011) (879)
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling (2000) (865)
How NF-κB is activated: the role of the IκB kinase (IKK) complex (1999) (864)
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways (2002) (843)
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. (1995) (832)
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 (1991) (807)
Oncogene jun encodes a sequence-specific trans- activator similar to AP-1 (1988) (804)
Mitogen-activated protein kinase cascades and regulation of gene expression. (1996) (797)
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus (1995) (784)
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase (1999) (774)
PI3Kγ is a molecular switch that controls immune suppression (2016) (770)
Is NF‐κB the sensor of oxidative stress? (1999) (768)
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene (1984) (758)
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor (1994) (755)
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing (2005) (753)
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria (2016) (752)
IKK-γ is an essential regulatory subunit of the IκB kinase complex (1998) (746)
Prevention of fat-induced insulin resistance by salicylate. (2001) (742)
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation (1996) (742)
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling (2009) (731)
The regulation of AP-1 activity by mitogen-activated protein kinases. (1996) (727)
Multiple ras functions can contribute to mammalian cell transformation (1995) (719)
NF-kappaB as a critical link between inflammation and cancer. (2009) (719)
Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation (1999) (717)
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein (1988) (716)
Inhibition of JNK activation through NF-κB target genes (2001) (711)
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. (2008) (699)
IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy (2005) (692)
Rapid and preferential activation of the c-jun gene during the mammalian UV response (1991) (681)
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. (2001) (673)
The gut–liver axis and the intersection with the microbiome (2018) (671)
Prolonged activation of jun and collagenase genes by tumour necrosis factor-α (1989) (664)
The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover (2006) (658)
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex (1990) (657)
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. (1993) (653)
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (1994) (652)
The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation* (1999) (638)
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun (1989) (637)
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling (2008) (619)
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling (2011) (598)
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 (1987) (594)
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. (2009) (586)
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation (2005) (586)
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling (2008) (584)
Control of cell cycle progression by c-Jun is p53 dependent. (1999) (579)
NF-kappaB and cancer-identifying targets and mechanisms. (2008) (576)
Induction of c‐fos expression through JNK‐mediated TCF/Elk‐1 phosphorylation. (1995) (565)
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain (1991) (562)
The IKK NF-kappa B system: a treasure trove for drug development. (2004) (561)
Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression (2004) (559)
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. (1997) (554)
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation (2018) (551)
A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas (2007) (551)
Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015) (539)
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. (2010) (536)
The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus (1999) (530)
The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion (2003) (526)
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. (2007) (525)
Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition (2002) (519)
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. (2014) (517)
c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions (1996) (513)
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis (2007) (512)
Regulation and function of the JNK subgroup of MAP kinases. (1997) (508)
Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies (2010) (508)
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage (2011) (506)
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. (2008) (501)
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. (1999) (499)
Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death (1999) (498)
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps (2000) (493)
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. (1997) (492)
Reparative inflammation takes charge of tissue regeneration (2016) (492)
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors (1996) (487)
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases (1994) (485)
A gp130–Src–YAP module links inflammation to epithelial regeneration (2015) (483)
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. (2014) (475)
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions (1997) (467)
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway (1994) (465)
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. (2002) (462)
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. (2004) (459)
Redundant pathways for negative feedback regulation of bile acid production. (2002) (457)
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. (2008) (452)
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment (2016) (452)
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. (1999) (447)
Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate (1998) (445)
IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development (2001) (445)
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. (2000) (443)
Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome (2017) (438)
Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. (1998) (437)
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. (2007) (428)
The tumor promoter arsenite stimulates AP‐1 activity by inhibiting a JNK phosphatase. (1996) (424)
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. (1981) (423)
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death (2020) (423)
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. (2006) (418)
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance (2005) (417)
Metallothioneins: Proteins in search of function (1985) (415)
Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch (2004) (413)
Inflammation and oncogenesis: a vicious connection. (2010) (409)
Immunosuppressive plasma cells impede T cell-dependent immunogenic chemotherapy (2015) (408)
Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. (1994) (407)
Obesity, inflammation, and liver cancer. (2012) (401)
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. (2012) (401)
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. (2000) (400)
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. (2010) (400)
JNK2 and IKKbeta are required for activating the innate response to viral infection. (1999) (399)
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide (2008) (399)
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. (1998) (398)
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 (2004) (393)
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. (2004) (393)
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. (2005) (393)
Expanding TRAF function: TRAF3 as a tri-faced immune regulator (2011) (392)
Requirement for p38α in Erythropoietin Expression A Role for Stress Kinases in Erythropoiesis (2000) (389)
Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling (2013) (387)
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. (1998) (382)
Cell Cycle–Regulated Modification of the Ribosome by a Variant Multiubiquitin Chain (2000) (382)
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2 (1999) (382)
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines (2010) (381)
Three distinct signalling responses by murine fibroblasts to genotoxic stress (1996) (376)
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. (2003) (375)
NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ (2007) (375)
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. (2014) (374)
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. (2010) (374)
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer (2015) (371)
The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer (2004) (371)
Evidence that reactive oxygen species do not mediate NF‐κB activation (2003) (368)
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK (1994) (366)
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain (1993) (365)
Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex (1999) (365)
Autocrine IL-6 signaling: a key event in tumorigenesis? (2008) (363)
Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death (*) (1996) (363)
New Twists in Gene Regulation by Glucocorticoid Receptor: Is DNA Binding Dispensable? (1998) (362)
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer (2010) (359)
Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene (1982) (354)
A lymphotoxin-driven pathway to hepatocellular carcinoma. (2009) (350)
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis (2011) (349)
Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase* (2000) (348)
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. (2006) (347)
Is NF-kappaB the sensor of oxidative stress? (1999) (346)
NF-κB in cancer: a marked target (2003) (345)
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 (1992) (344)
Control of transcription factors by signal transduction pathways: the beginning of the end. (1992) (344)
Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin (2007) (343)
Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury (1998) (340)
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity (1992) (340)
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. (1999) (340)
IKKα controls formation of the epidermis independently of NF-κB (2001) (339)
Mitogen‐Activated Protein Kinase Cascades as Regulators of Stress Responses (1998) (339)
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B (1995) (338)
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. (2005) (334)
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. (2016) (333)
Inhibition of JNK activation through NF-kappaB target genes. (2001) (330)
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity (2017) (327)
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development (1999) (326)
Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin (2009) (323)
Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers (2004) (323)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. (2005) (322)
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction (2010) (320)
Cancer and Inflammation: Promise for Biologic Therapy (2010) (319)
JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. (1993) (316)
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver (2010) (314)
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. (2007) (312)
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. (2000) (309)
The Mammalian UV Response c-Jun Induction Is Required for Exit from p53-Imposed Growth Arrest (2000) (306)
DNA methylation markers for diagnosis and prognosis of common cancers (2017) (304)
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. (2010) (303)
Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. (2004) (302)
Calcineurin preferentially synergizes with PKC‐θ to activate JNK and IL‐2 promoter in T lymphocytes (1998) (294)
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. (2009) (293)
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. (1994) (293)
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters (1987) (290)
p62 in Cancer: Signaling Adaptor Beyond Autophagy (2016) (287)
CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response (2003) (287)
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (1999) (286)
NAK is an IκB kinase-activating kinase (2000) (284)
IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα (2003) (283)
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates (2006) (281)
Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids (1984) (280)
Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. (2013) (277)
NF‐κB and cancer: Mechanisms and targets (2006) (277)
Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. (1995) (277)
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. (1993) (276)
Obesity and Cancer: The Oil that Feeds the Flame. (2016) (274)
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. (2006) (274)
Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B (1995) (273)
MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer (2014) (273)
Sestrins inhibit mTORC1 kinase activation through the GATOR complex. (2014) (271)
The IKK/NF-kappa B pathway. (2002) (270)
Targeting Inflammation in Cancer Prevention and Therapy (2016) (264)
Sestrins orchestrate cellular metabolism to attenuate aging. (2013) (263)
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. (1988) (259)
The Ras-JNK pathway is involved in shear-induced gene expression (1996) (259)
The control of cell motility and epithelial morphogenesis by Jun kinases. (2004) (258)
NF-κB signaling, liver disease and hepatoprotective agents (2008) (257)
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis (2015) (257)
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. (2014) (251)
Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation (2011) (250)
Immunity by ubiquitylation: a reversible process of modification (2005) (248)
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. (2005) (248)
Different requirements for formation of Jun: Jun and Jun: Fos complexes. (1989) (247)
Tumor promotion via injury- and death-induced inflammation. (2011) (246)
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. (2000) (244)
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation (2001) (244)
Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex (2008) (242)
The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. (2011) (242)
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. (2007) (241)
A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells (1987) (241)
IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss (2005) (235)
Signal transduction from cell surface to nucleus in development and disease (1992) (234)
The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals (1994) (234)
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma (2015) (232)
An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis (1999) (232)
p63 induces key target genes required for epidermal morphogenesis (2007) (230)
Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. (1995) (228)
Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. (1989) (227)
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. (2004) (224)
Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. (1984) (223)
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. (2008) (223)
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. (2012) (222)
Anthrolysin O and Other Gram-positive Cytolysins Are Toll-like Receptor 4 Agonists (2004) (221)
Dissection of functional domains of the pituitary-specific transcription factor GHF-1 (1989) (221)
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. (1992) (220)
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (1998) (215)
Ubiquitous and lymphocyte‐specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. (1989) (215)
Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity (1990) (212)
Function of the homeodomain protein GHF1 in pituitary cell proliferation. (1991) (212)
Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. (2004) (208)
IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis (2001) (205)
Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues (1990) (204)
NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation (2009) (204)
JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action? (1998) (201)
Structure and chromosomal localization of the functional intronless human JUN protooncogene. (1988) (201)
Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene (1985) (200)
The IκB kinase – a bridge between inflammation and cancer (2008) (199)
IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis (2004) (198)
An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation (2008) (198)
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. (2001) (197)
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. (2004) (197)
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. (2004) (193)
Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. (2002) (192)
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. (1994) (189)
A role for MEK kinase 1 in TGF‐β/activin‐induced epithelium movement and embryonic eyelid closure (2003) (188)
Human metallothionein genes: structure of the functional locus at 16q13. (1990) (186)
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. (1988) (186)
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. (2006) (185)
Cytosine methylation does not affect binding of transcription factor Sp1. (1988) (185)
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. (2003) (184)
TNFR signaling: ubiquitin‐conjugated TRAFfic signals control stop‐and‐go for MAPK signaling complexes (2009) (184)
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer (2010) (183)
Interleukin 1 regulates human metallothionein gene expression (1985) (181)
A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing (2016) (181)
NOD2 and Crohn's disease: loss or gain of function? (2005) (181)
Transcriptional control of GH expression and anterior pituitary development. (1993) (181)
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P (2018) (178)
Streptolysin O Promotes Group A Streptococcus Immune Evasion by Accelerated Macrophage Apoptosis* (2009) (178)
Stressin' Sestrins take an aging fight (2010) (177)
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium (2004) (176)
ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks* (2000) (175)
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site (2008) (172)
The commonly used antimicrobial additive triclosan is a liver tumor promoter (2014) (171)
Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress (2015) (170)
Evidence that reactive oxygen species do not mediate NF-kappaB activation. (2003) (169)
Tissue‐specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans‐acting factor. (1987) (169)
IKKβ Is Required for Peripheral B Cell Survival and Proliferation1 (2003) (166)
NF-kappaB and cancer: mechanisms and targets. (2006) (164)
AP-1--glucocorticoid receptor crosstalk taken to a higher level. (2001) (163)
Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling (2003) (162)
Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. (1994) (159)
Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. (2005) (159)
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNA (1984) (157)
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. (2016) (157)
IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation (2008) (156)
NF-kappaB in cancer: a marked target. (2003) (156)
Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. (1991) (156)
Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response (1980) (155)
NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation* (1998) (154)
Immune Infiltration and Prostate Cancer (2015) (153)
RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA (2000) (153)
Crystal structure of inhibitor of κB kinase β (IKKβ) (2011) (152)
Opposing functions of IKKβ during acute and chronic intestinal inflammation (2008) (151)
Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation (2011) (151)
Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium (2005) (149)
Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death (2004) (148)
Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac* (1996) (148)
Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts (2014) (147)
The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF (2001) (146)
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes (2015) (144)
Too many transcription factors: positive and negative interactions. (1990) (143)
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. (2014) (143)
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. (1998) (143)
IKKalpha controls formation of the epidermis independently of NF-kappaB. (2001) (142)
Double-stranded RNA-dependent Protein Kinase Phosphorylation of the α-Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis* (2006) (140)
Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart (2012) (140)
The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells (1991) (140)
IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. (2003) (138)
Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. (2018) (138)
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation (2012) (137)
Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. (2010) (137)
Tumor infiltrating B-cells are increased in prostate cancer tissue (2014) (137)
IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells (2007) (136)
NAK is an IkappaB kinase-activating kinase. (2000) (136)
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. (2008) (136)
Oxidative stress and gene expression: The AP‐1 and NF‐κB connections (2001) (135)
Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. (1990) (135)
A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. (1996) (135)
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. (1998) (134)
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. (1998) (134)
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas (2011) (133)
Metallothionein gene expression is regulated by serum factors and activators of protein kinase C (1987) (133)
Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity (1987) (132)
Tumor-Elicited Inflammation and Colorectal Cancer. (2015) (130)
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. (2011) (130)
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. (2002) (130)
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. (2001) (129)
Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? (2019) (129)
Inflammation-activated protein kinases as targets for drug development. (2005) (129)
The Chemokine CXCL16 and Its Receptor, CXCR6, as Markers and Promoters of Inflammation-Associated Cancers (2009) (128)
Fructose stimulated de novo lipogenesis is promoted by inflammation (2020) (128)
GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. (1993) (128)
The control of mRNA stability in response to extracellular stimuli. (2002) (126)
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. (2014) (126)
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures. (1979) (125)
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins (1994) (125)
Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 Receptor-insulin receptor substrate and STAT3 signaling (2015) (124)
Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase (2004) (124)
The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. (1989) (124)
Trans‐activation of an upstream early gene promoter of bovine papilloma virus‐1 by a product of the viral E2 gene. (1987) (122)
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. (2004) (122)
The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein (1989) (122)
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse (2014) (122)
A simplified method for the preparation of transcriptionally active liver nuclear extracts. (1990) (122)
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis (2013) (121)
Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. (2016) (121)
Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. (2019) (120)
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis (2020) (119)
A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation (1993) (119)
Immunotherapy, Inflammation and Colorectal Cancer (2020) (119)
The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. (1989) (115)
Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)* (1999) (115)
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer (1986) (115)
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. (2019) (112)
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase (1997) (108)
Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. (1992) (108)
Negative transcriptional regulation by nuclear receptors. (1994) (108)
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. (2013) (107)
Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA (2015) (105)
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. (2004) (105)
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production (2007) (104)
AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. (2001) (104)
NF-κB prevents β cell death and autoimmune diabetes in NOD mice (2007) (104)
Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. (1989) (104)
Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis (2014) (102)
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation (2021) (102)
A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor) (1993) (101)
IKK beta is required for peripheral B cell survival and proliferation. (2003) (101)
From death receptor to reactive oxygen species and c‐Jun N‐terminal protein kinase: the receptor‐interacting protein 1 odyssey (2007) (99)
Inflammation and cancer: the long reach of Ras (2005) (99)
Altering the specificity of signal transduction cascades: positive regulation of c‐Jun transcriptional activity by protein kinase A. (1994) (98)
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ (2011) (98)
Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia (1985) (97)
The Immunobiology of Hepatocellular Carcinoma in Humans and Mice: Basic Concepts and Therapeutic Implications. (2019) (97)
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. (2008) (97)
Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. (1982) (97)
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. (2006) (96)
The AP-1 complex and its role in transcriptional control by protein kinase C (1991) (96)
Conditional ablation of Ikkb inhibits melanoma tumor development in mice. (2010) (96)
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. (2011) (95)
Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element. (1985) (95)
NRF2 as a regulator of cell metabolism and inflammation in cancer. (2020) (95)
Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age? (2021) (94)
Human metallothionein genes are clustered on chromosome 16. (1984) (93)
Signalling pathways: Kinase regulation in inflammatory response (2000) (92)
Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. (1990) (91)
IKKα negatively regulates ASC-dependent inflammasome activation (2014) (91)
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade (2014) (91)
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11) (2013) (90)
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. (1990) (90)
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. (2007) (89)
p62/SQSTM1—Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer (2016) (89)
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. (2012) (89)
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. (2008) (88)
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. (2017) (88)
IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. (2001) (88)
Signal transduction and gene control. (1991) (87)
The Role of the Ah Receptor and p38 in Benzo[a]pyrene-7,8-dihydrodiol and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced Apoptosis* (2003) (86)
Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. (1994) (85)
NF-kappaB in mammary gland development and breast cancer. (2003) (85)
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor (1994) (83)
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1 (2001) (83)
Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector. (1983) (83)
Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. (2011) (82)
In vivo competition between a metallothionein regulatory element and the SV40 enhancer. (1986) (82)
B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia (2010) (81)
NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia* (2010) (80)
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. (2005) (80)
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. (2013) (79)
Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105 (1992) (79)
The IKK/NF-kappaB pathway. (2002) (79)
A Glycine-Dependent Riboswitch That Uses Cooperative Binding to Control Gene Expression (2004) (79)
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. (2003) (78)
Structure and tissue-specific expression of the human metallothionein IB gene (1986) (78)
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. (2010) (78)
Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. (2015) (78)
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals (2020) (77)
Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation (2000) (76)
Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements (1993) (76)
The Carboxyl-Terminal Region of IκB Kinase γ (IKKγ) Is Required for Full IKK Activation (2002) (76)
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production (2006) (75)
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. (2019) (75)
YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis (2017) (74)
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages (2015) (74)
Inflammation and liver tumorigenesis (2013) (74)
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer (2008) (73)
Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription. (1990) (73)
Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids. (1996) (73)
In vitro activation of the HIV‐1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. (1987) (73)
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. (2019) (73)
Sestrin regulation of TORC1: Is Sestrin a leucine sensor? (2016) (72)
Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. (1989) (72)
NF- κ B and Cancer — Identifying Targets and Mechanisms (2008) (72)
Transcription factors AP‐3 and AP‐2 interact with the SV40 enhancer in a mutually exclusive manner. (1989) (72)
Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1 (1988) (71)
Industrial yeasts display tandem gene iteration at the CUP1 region (1983) (71)
Sequence‐specific and general transcriptional activation by the bovine papillomavirus‐1 E2 trans‐activator require an N‐terminal amphipathic helix‐containing E2 domain. (1988) (71)
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction (2016) (71)
Complexities of gene regulation by cAMP. (1989) (70)
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation (1992) (70)
Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. (2016) (69)
Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin (2008) (69)
Sestrins at the crossroad between stress and aging (2010) (69)
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? (1998) (69)
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. (2012) (68)
IκB Kinase Complex α Kinase Activity Controls Chemokine and High Endothelial Venule Gene Expression in Lymph Nodes and Nasal-Associated Lymphoid Tissue1 (2004) (67)
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. (2009) (67)
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 (2011) (67)
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. (2001) (67)
M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding (1995) (67)
Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs (2004) (67)
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression (2009) (66)
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. (2003) (66)
NF-κB in Mammary Gland Development and Breast Cancer (2003) (66)
Cutting Edge: IL-10–Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production (2012) (64)
Ikappa B kinaseβ/nuclear factor‐κB activation controls the development of liver metastasis by way of interleukin‐6 expression (2009) (64)
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis (2010) (64)
p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. (2013) (63)
Stress-induced JNK Activation Is Independent of Gadd45 Induction* (1999) (63)
Role of TLR2‐dependent inflammation in metastatic progression (2011) (63)
The tumor suppressor activity of IKKα in stratified epithelia is exerted in part via the TGF-β antiproliferative pathway (2008) (62)
Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis (2003) (62)
AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation (2001) (62)
Primary induction of metallothionein by dexamethasone in culture rat hepatocytes. (1980) (62)
An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. (2013) (61)
DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA (2009) (61)
Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. (2012) (61)
Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity* (2002) (59)
Progesterone induction of metallothionein-IIA gene expression. (1988) (59)
The anti-death machinery in IKK/NF-kappaB signaling. (2005) (58)
Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions (2003) (58)
Matrix Metalloproteinase-1-mediated Up-regulation of Vascular Endothelial Growth Factor-2 in Endothelial Cells* (2012) (58)
Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway (2005) (58)
A Dual Role for Ikkα in Tooth Development (2004) (58)
Sestrins are evolutionarily conserved mediators of exercise benefits (2020) (57)
Integrative genomic analysis of mouse and human hepatocellular carcinoma (2018) (57)
JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration (2013) (57)
Crystal structure of inhibitor of kappaB kinase beta. (2011) (57)
Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc. (2005) (57)
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. (2021) (57)
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. (2012) (57)
Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases (2012) (57)
Inflammation and Cancer (2008) (57)
The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity (2012) (56)
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. (1990) (56)
ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation (2016) (56)
Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids (1981) (55)
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. (2016) (55)
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. (2019) (55)
Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. (1981) (55)
Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice (2008) (55)
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. (2009) (55)
Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. (2009) (54)
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. (2007) (54)
Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model1 (2006) (53)
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. (2022) (53)
NRF2 Activates Growth Factor Genes and Downstream AKT Signaling to Induce Mouse and Human Hepatomegaly. (2020) (53)
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. (2020) (53)
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death (2018) (53)
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia (2021) (52)
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element. (1989) (52)
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. (2002) (51)
Hepatocyte IKK β / NF-κ B inhibits tumor promotion and progression by preventing oxidative stress driven STAT 3 activation (2010) (51)
Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli. (1992) (51)
Induction of metallothionein in HeLa cells by dexamethasone and zinc. (1981) (50)
Gene amplification in yeast: CUP1 copy number regulates copper resistance (1983) (50)
Transcriptional regulation of the Th17 immune response by IKKα (2011) (50)
Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation. (1990) (49)
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1 (2016) (49)
Human TRAF 3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis (2010) (49)
The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. (1991) (49)
Emerging roles of Lys63‐linked polyubiquitylation in immune responses (2015) (49)
Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth (2015) (49)
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. (1998) (48)
Chemotherapy, immunity and microbiota—a new triumvirate? (2014) (48)
Genetic dissection of antigen receptor induced-NF-κB activation (2004) (47)
Activation of activating protein 1 during hepatic acute phase response. (1993) (47)
Obesity, autophagy and the pathogenesis of liver and pancreatic cancers (2012) (47)
Oncogene at last--c-Jun promotes liver cancer in mice. (2003) (46)
The IL-23 to IL-17 cascade inflammation-related cancers. (2015) (46)
The human metallothionein gene family: structure and expression. (1984) (45)
CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-κB activation (2004) (45)
Epithelial Cell IκB-Kinase β Has an Important Protective Role in Clostridium difficile Toxin A-Induced Mucosal Injury1 (2006) (44)
[25] Signaling pathways leading to nuclear factor-κB activation (2000) (44)
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity (1997) (43)
Critical role for IL-1β in DNA damage-induced mucositis (2014) (43)
Regulation of late B cell differentiation by intrinsic IKKα-dependent signals (2007) (43)
NF-kB as a Critical Link Between Inflammation and Cancer (2009) (43)
A single amino acid change in CUP2 alters its mode of DNA binding (1990) (43)
JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. (2011) (41)
Anthrax lethal factor and edema factor act on conserved targets in Drosophila. (2006) (41)
The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. (2019) (41)
Genetic Properties Influencing the Evolvability of Gene Expression (2007) (40)
IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways (2011) (40)
Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-α, Interleukin-1β, Interleukin-6, and Nuclear Factor-κB in Two Models of Cholestasis (2007) (40)
Loss of Ikkβ Promotes Migration and Proliferation of Mouse Embryo Fibroblast Cells* (2006) (40)
Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1. (1990) (39)
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. (2002) (39)
Control of AP-1 activity by signal transduction cascades. (1993) (39)
Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells (1980) (39)
DNA‐binding activity of jun is increased through its interaction with Fos (1990) (38)
Dangerous liaisons: STAT3 and NF- κ B collaboration and crosstalk in cancer (2010) (38)
Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. (2020) (38)
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. (2005) (37)
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines (2014) (37)
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation (2014) (37)
"Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. (2021) (36)
Is NF-κB2/p100 a direct activator of programmed cell death? (2002) (36)
IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. (2000) (36)
Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. (2011) (35)
Signaling pathways leading to nuclear factor-kappa B activation. (2000) (34)
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. (2007) (34)
I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. (2004) (33)
The therapeutic value of targeting inflammation in gastrointestinal cancers. (2014) (33)
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells. (1984) (33)
Multicellular Stalk-Like Structures inSaccharomyces cerevisiae (1998) (32)
Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. (2007) (32)
Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET. (2018) (31)
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. (2006) (31)
Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease (2020) (31)
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression (2016) (31)
Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. (2011) (30)
Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. (2019) (30)
Promoter elements and transcriptional regulation of the acetylcholinesterase gene. (1993) (30)
The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. (1999) (29)
Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation (2021) (29)
Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response. (2014) (29)
IKKβ as a target for treatment of inflammation induced bone loss (2005) (29)
Regulation of human and yeast metallothionein gene transcription by heavy metal ions. (1993) (29)
Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome. (1987) (28)
Neuronal IκB Kinase β Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System1 (2009) (28)
Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3 (2014) (27)
The Human CYP1A1 Gene Is Regulated in a Developmental and Tissue-specific Fashion in Transgenic Mice* (2004) (26)
Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. (2020) (26)
IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways (2018) (26)
MEKK1 Binds HECT E3 Ligase Itch by Its Amino-Terminal RING Motif to Regulate Th2 Cytokine Gene Expression1 (2009) (26)
Targets for signal-transducing protein kinases. (1988) (26)
STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. (2021) (25)
Radioprotection with interleukin-1 comparison with other cytokines (1986) (25)
The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation (2013) (25)
Publisher Correction: The gut–liver axis and the intersection with the microbiome (2018) (24)
Inhibitor-κB Kinase in Tumor Promotion and Suppression During Progression of Squamous Cell Carcinoma (2007) (24)
A dual role for Ikk alpha in tooth development. (2004) (24)
Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105. (1992) (24)
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection (2013) (24)
Inhibitor ?B Kinase Binding by Inhibitor ?B Kinase ? (2007) (23)
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation (2015) (23)
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. (2012) (22)
The Role of IL-17 Signaling in Regulation of the Liver–Brain Axis and Intestinal Permeability in Alcoholic Liver Disease (2016) (22)
Role for IKK2 in muscle: waste not, want not. (2006) (22)
Is NF-kappaB2/p100 a direct activator of programmed cell death? (2002) (22)
IKK‐β‐mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury (2011) (21)
Analysis of the IKKβ/NF‐κB signaling pathway during embryonic angiogenesis (2008) (21)
Role of microglial IKK b in kainic acid-induced hippocampal neuronal cell death (2008) (21)
Targeted deletion of hepatocyte Ikkbeta confers growth advantages. (2009) (21)
Evidence from EXAFS for a copper cluster in the metalloregulatory protein CUP2 from yeast (1991) (21)
NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia (2020) (21)
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia (2017) (21)
Mechanisms of glucocorticoid hormone action. (1984) (20)
Regulation of antitumor immunity by inflammation-induced epigenetic alterations (2021) (20)
NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. (2014) (20)
IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites (2013) (20)
Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis (2013) (20)
P38alpha Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species (2011) (20)
Immunoregulatory genes and immunosuppression by glucocorticoids. (1996) (19)
Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1 (2017) (19)
Prion propagation in mice lacking central nervous system NF-kappaB signalling. (2008) (18)
Genetic dissection of antigen receptor induced-NF-kappaB activation. (2004) (18)
Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer (2020) (18)
GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer (2017) (18)
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory (2022) (17)
IKK{beta} as a target for treatment of inflammation induced bone loss. (2005) (17)
The neglected brothers come of age: B cells and cancer. (2021) (17)
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis (2022) (17)
A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha (1996) (17)
Erratum: The commonly used antimicrobial additive triclosan is a liver tumor promoter (Proc Natl Acad Sci USA (2014) 111 (17200-17205) DOI: 10.1073/pnas.1419119111) (2015) (17)
Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. (2007) (17)
I&kgr;B-kinase/nuclear factor-&kgr;B signaling prevents thermal injury–induced gut damage by inhibiting c-Jun NH2-terminal kinase activation* (2007) (16)
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation (2019) (16)
Transcriptional control mechanisms which regulate the expression of human metallothionein genes. (1987) (16)
A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter. (1990) (16)
New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance (2018) (16)
Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach (2019) (16)
Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. (2007) (15)
Assays for JNK and p38 mitogen-activated protein kinases. (2000) (15)
MEK kinase 1 is a negative regulator of virus‐specific CD8+ T cells (2006) (15)
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. (2022) (15)
Studies of the Mechanism of Glucocorticoid Hormone Action (1983) (15)
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. (1992) (15)
New EMBO Member's Review IKKa, a critical regulator of epidermal differentiation and a suppressor of skin cancer (2008) (14)
Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes. (1992) (14)
Differentiation of Lactotrope Precursor GHFT Cells in Response to Fibroblast Growth Factor-2* (2000) (14)
Peering into the aftermath: JAKi rips STAT3 in cancer (2010) (14)
From Liver Fat to Cancer: Perils of the Western Diet (2021) (14)
Sphingolipids: The Oil on the TRAFire That Promotes Inflammation (2010) (13)
Transcriptional control and the integration of cell-autonomous and environmental cues during development. (1990) (13)
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis (2021) (13)
CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease (2021) (13)
CUP2 binds in a bipartite manner to upstream activation sequence c in the promoter of the yeast copper metallothionein gene (1996) (12)
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control (2020) (12)
The IκB kinase (IKK) complex as a critical regulator of immune responses (2005) (12)
IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents (2017) (12)
Immunoregulatory Genes and Immunosuppression by Glucocorticoids (1997) (12)
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. (2007) (11)
P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis (2022) (10)
Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. (1990) (10)
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome (2022) (10)
Whipping NF-κB to Submission via GADD45 and MKK7. (2014) (10)
Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes. (1984) (10)
New Approaches for Studying Alcoholic Liver Disease (2014) (10)
Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). (2010) (10)
Cell Metabolism Previews NCOA 5 , IL-6 , Type 2 Diabetes , and HCC : The Deadly Quartet (2014) (9)
Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. (2007) (9)
Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity (2017) (9)
Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones (2005) (9)
NF-κB: A Double-Edged Sword Controlling Inflammation (2022) (8)
Signaling cascades and inflammasome activationin microbial infections (2016) (8)
Externally triggered on-demand drug release and deep tumor penetration (2012) (8)
Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes (2015) (8)
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade. (2012) (7)
Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. (2016) (7)
Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. (2010) (7)
NF-kB in Health and Disease (2011) (7)
Crystal structure of inhibitorof k Bkinase b (2011) (7)
Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries. (2019) (7)
Caspase-1 Independent IL-1 β Activation in Neutrophil Dependent Inflammation (2011) (7)
Common flora and intestine (2013) (6)
Metallothionein structure and function in regulating the trace element in human (1988) (6)
Non-degradable collagen increases liver fibrosis but not hepatocellular carcinoma in mice. (2021) (6)
CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. (2012) (6)
Rsk Tolls the bell for endocytosis in DCs (2007) (6)
NF-k B as a Critical Link Between Inflammation and Cancer (2009) (6)
Macrophage Expression of HIF-1 α Suppresses T cell Function and Promotes Tumor Progression (2010) (6)
Analysis of NF-κB activation in mouse intestinal epithelial cells. (2015) (5)
Prion propagation in mice lacking central nervous system NFk B signalling (2008) (5)
Maintenance of metabolic homeostasis by Sestrin 2 and 3 (2013) (5)
Inhibition of NFk B Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of I k B Kinase * (2000) (5)
Intercellular telomere transfer extends T cell lifespan (2020) (5)
PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. (2022) (4)
Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. (2022) (4)
JNK1 deficiency limits macrophage mediated antigen-induced arthritis (2011) (4)
Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: Advantages of targeting upstream kinases MKK3 or MKK6 (2012) (4)
NF-kB : a network hub controlling immunity, inflammation, and cancer : a subject collection from Cold Spring Harbor perspectives in biology (2010) (4)
Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway (2006) (4)
Stress of Life: Stress and Adaptation from Molecules to Man (1997) (4)
Fibroblast-recruited , tumor-infiltrating CD 4 + T cells stimulate mammary cancer metastasis through RANKL-RANK signaling (2011) (4)
Macropinocytosis: the big drinker behind cancer cell self-consumption (2021) (4)
Constitutive Baff Signalling Plays a Key Role in CLL Development by Promoting Tumor Cell Survival (2008) (3)
THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION (1982) (3)
Developing diversity (2006) (3)
IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines (2022) (3)
NF-κB in health and disease (2011) (3)
NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas (2011) (3)
VISION : Cancer research in flames (2005) (3)
Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling (2016) (3)
Department Of Health And Human Services National Institutes Of Health National Institute Of Environmental Health Sciences Minutes Of The National Advisory Environmental Health Sciences Council (2010) (3)
NF-κB Signal Transduction by IKK Complexes (2006) (3)
Analysis and identification of protein-protein interactions using protein recruitment systems. (2000) (3)
The JNK Family of MAP Kinases: Regulation and Function (1998) (3)
microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer (2013) (3)
Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. (2019) (3)
Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor—MIG6 Axis (2021) (2)
Interleukin 1Regulates HumanMetallothionein GeneExpression (1985) (2)
Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH 2 -Terminal Kinase-Speciﬁc Kinase (1997) (2)
Innate Immunity, Inflammation and Colorectal Cancer (2013) (2)
cis- and trans-Acting Genetic Elements Responsible for Induction of Specific Genes by Tumor Promoters, Serum Factors, and Stress (2020) (2)
Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. (1985) (2)
Concurrent Disruption of Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. (2021) (2)
Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential (2022) (2)
Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity (2018) (2)
BAFF Accelerates Development of Chronic Lymphocytic Leukemia in TCL1 Transgenic Mice. (2007) (2)
Anti-miR-135b in colon cancer treatment: Results from a preclinical study. (2012) (2)
Oncogenes as Transcriptional Regulators (1997) (2)
Toxin A-Induced Mucosal Injury difficile Clostridium Important Protective Role in Has an β B-Kinase κ Epithelial Cell (2006) (2)
Regulation of Gene Expression by Posttranslational Modification of Transcription Factors (1988) (1)
The IкB Kinase (IKK) Complex (2003) (1)
B CELL CONCENTRATION IN HIGH RISK PROSTATE CANCER SPECIMENS AFTER NEOADJUVANT RITUXIMAB: MP70‐20 (2018) (1)
Transcriptional Activation of Human and Yeast Metallothionein Genes by Heavy Metal Ions (1990) (1)
The role of IL-6 and IL-23 in colitis associated cancer (2009) (1)
Gene Expression: General And Cell-Type-Specific (2012) (1)
B Cell Activating Factor and c-Myc Regulate the Progression of Chronic Lymphocytic Leukemia. (2009) (1)
NF-KB Signal Transduction by IKK G)mplexes (2006) (1)
28 Conditional Deletion of IkappaB Kinase Beta (Ikk-Beta) Accelerates Helicobacter-Dependent Gastric Apoptosis and Preneoplasia (2008) (1)
Myeloid IKK b Promotes Antitumor Immunity by Modulating CCL11 and the Innate Immune Response (2014) (1)
GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein (1989) (1)
Negative regulation of p53 expression is an essential, rate-limiting function of Jun in the control of cell cycle progression (2000) (1)
Short Term Metformin Intervention Inhibits IL-6 and IL-1β Secretion and Prevents Acute Respiratory Distress Syndrome-Implications for COVID-19 (2020) (1)
Model Confers Protection in a Cerebral Malaria Glycosylphosphatidylinositol In Vitro and Plasmodium falciparum Response to Disruption of JNK 2 Decreases the Cytokine (2006) (1)
Molecular and Cellular Pathobiology p 38 a Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species (2012) (1)
Short Communication Prion propagation in mice lacking central nervous system NF-kB signalling (2008) (1)
Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. (2020) (1)
Kinase Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System 1 (2009) (1)
Tumor infiltrating B-cells are increased in prostate cancer tissue (2014) (1)
S2052 c-Jun Nh2-Terminal Kinase 1 Is a Critical Regulator for the Development of Chemical-Induced Gastric Cancer in Mice (2008) (1)
Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation (2012) (1)
A dual role for lkkalpha in tooth development (2004) (1)
5-bromo-2-deoxyuridine (BrdU) and 7-amino-actinomycin (7-AAD) staining for cell proliferation assay (2007) (1)
Abstract 10070: Sestrin2 Mediates the LKB1-AMPK Signaling Cascade in the Ischemic Heart (2011) (1)
The Effect of Mtorc1 Inhibition on Nafld and Subsequent Hcc Development (2016) (1)
Cell type specific expression of the growth hormone gene and its control by GHF-1. (1990) (1)
IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways (2011) (1)
NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals (2016) (1)
Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice (2022) (1)
Oxidized mitochondrial DNA: a protective signal gone awry. (2023) (1)
Immunoprecipitation of endogenous MEKK1 and kinase assay (2007) (1)
Epithelial cell-intrinsic IKKbeta expression regulates innate and adaptive immunity in the gut (2007) (1)
FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING Activation (2022) (1)
Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome (2023) (1)
High-fat or sugar intake Endocrine disorders Sedentary lifestyle Hereditary factors Medications Obesity NAFLD (2012) (0)
Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth (2022) (0)
CHAPTER 2 N FK B Signal Transduction by IKK G ) mplexes (2019) (0)
Biochemical characterization and purification of the iκb kinase (1996) (0)
Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth (2022) (0)
Sestrin2 is cardioprotective against ischemia/reperfusion injury by promoting LKB1‐mediated AMPK activation (2013) (0)
P-411 High dose methotrexate (MTX) and interferons (IF) in malignant mesothelioma. A Scandinavian phase I study (2005) (0)
Abstract B045: Immunosuppressive plasmocytes impede T-cell-dependent immunogenic chemotherapy (2016) (0)
IL6ST–induced muscarinic receptor opens goblet cell associated antigen passages to suppress alcoholic liver disease (2021) (0)
Twenty-eighth annual meeting of the British Association for Cancer Research (in conjunction with the second annual meeting of the Association of Cancer Physicians). April 6-8, 1987, Newcastle-upon-Tyne, UK. Abstracts. (1987) (0)
The Roles of Ik(Beta) Kinases in Prostate Carcinogenesis and the Effect of Their Inhibition on Survival of Prostate Tumors (2005) (0)
Abstract A138: Identification of key immune regulators that control obesity-induced liver inflammation and diseases (2016) (0)
gene during the mammalian UV response. Rapid and preferential activation of the c-jun (2013) (0)
Regulation of antitumor immunity by inflammation-induced epigenetic alterations (2021) (0)
Detection of in vivo ubiquitinated protein (2007) (0)
72: Inflammation in colorectal and liver tumorigenesis (2014) (0)
Abstract B14: Anti-miR-135b in colon cancer treatment (2012) (0)
Abstract A095: Immunosuppressive plasmocytes regulate the development of NASH-induced HCC (2016) (0)
Role of Inflammation in Control of Hepatic Lipid Metabolism—New Insights to the Pathogenesis of NASH (2019) (0)
DMD #12138 DIFFERENTIAL REGULATION OF HEPATIC TRANSPORTERS IN THE ABSENCE OF TNF-α, IL-1β, IL-6 AND NF-κB IN TWO MODELS OF CHOLESTASIS (2006) (0)
Abstract 976: Junctional adhesion molecule-A (JAM-A) expression is downmodulated by miR-21 during colorectal cancer progression (2014) (0)
Cancer esearch oenvironment and Immunology rophage Expression of Hypoxia-Inducible Factor-1 α presses T-Cell Function and Promotes R or Progression (2010) (0)
Diabesity? No worries, FKBP11 to the rescue. (2022) (0)
Abstract PR3: Myofibroblasts activated upon tissue injury and hypoxia promote development of castration-resistant prostate cancer. (2013) (0)
Immune surveillance and tumor immunity (SY2-5) Chairpersons: Takashi Nishimura, Laurence Zitvogel (2010) (0)
Crystal Structure of Inhibitor of kappaB kinase beta (I4122) (2011) (0)
Mapping of the Inducible I (cid:107) B Phosphorylation Sites That Signal Its Ubiquitination and Degradation† (1996) (0)
Part III. Transcription and Translation: Nuclear and Cytoplasmic Events (2010) (0)
Abstract SY19-01: Tumor-elicited inflammation in colorectal cancer (2017) (0)
An IKKβ-IL-17 axis fine-tunes Ab responses to sublingual immunization (120.7) (2012) (0)
Abstract IA08: p62/SQSTM1 accumulation links chronic tissue damage to malignant progression in liver and pancreas (2016) (0)
mediates susceptibility to Yersinia pseudotuberculosis in mice. (2008) (0)
Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation (2022) (0)
Role of myeloid cells and inflammation in cancer progression and metastasis (2009) (0)
Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor- (cid:2) B kinase subunit (cid:3) -dependent atherosclerosis in pulmonary arteries (2019) (0)
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity (2017) (0)
Inflammation, metabolism, aging and cancer: Dangerous Liaisons (2010) (0)
TheTransactivating Domainofthec-JunProto-Oncoprotein (1991) (0)
Hepatocyte-specific disruption of IKKβ reveals its essential role in prevention of apoptosis, but does not affect liver morphogenesis and regeneration (2003) (0)
Trans-activation ofan upstreamearly gene promoterofbovine papilloma virus-1 bya product oftheviral E2gene (1987) (0)
Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1 (2018) (0)
NF-kappa B. but is not sufficient for its dissociation from Phosphorylation of I kappa B alpha precedes (2013) (0)
Supplemental Information Maintenance of Metabolic Homeostasis by Sestrin 2 and Sestrin 3 (2012) (0)
Microsoft Word-DLSFINAL.DOC (2006) (0)
Choline uptake and metabolism modulate macrophage immunity (2019) (0)
Abstracts of the Annual Congress of the British Society for Immunology. December 6-10, 2010. Liverpool, United Kingdom. (2010) (0)
Autoinduction ofTransforming GrowthFactor 13 IsMediated by theAP-1Complex (1990) (0)
Abstract 3528: Influence of obesity-associated intra-tumor microbes on exacerbating cancer severity (2022) (0)
An IKK{beta}-IL-17 axis fine-tunes Ab responses to sublingual immunization (2012) (0)
CONTRIBUTIONS OF PI3‐KINASE AND NF‐KB SIGNALING PATHWAYS IN B LYMPHOCYTE DIFFERENTIATION AND SURVIVAL: 178 (2004) (0)
Abstract 3: Imaging of stromal cells during hepatocellular metastasis formation in the RFP-MUP-uPA mouse (2014) (0)
From Inflammation to Skin Biology : Protein Kinase Cascades That Control NF-кB Activity (2000) (0)
RapidandPreferential Activation ofthec-junGeneduring the Mammalian UV Response (1991) (0)
Abstract A38: Steatohepatitis-associated hepatocellular carcinoma: Evidence of a keratin-based disease. (2013) (0)
Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. (2023) (0)
NF- κ B activation in hypothalamic POMC neurons is essential in illness- and leptin-induced anorexia (2010) (0)
Cancer Metastasis: Role of Inflammation in Metastatic Progression (2011) (0)
The role of IL-1{beta} on IKK{beta} inhibitors induced neutrophilia (2011) (0)
Sestrin, a novel regulator of TOR-dependent cell growth and metabolism (2009) (0)
Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer (2020) (0)
An Essential Role for Nuclear Factor (cid:107) B in Promoting Double Positive Thymocyte Apoptosis (1998) (0)
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia (vol 114, pg E1432, 2017) (2017) (0)
Phosphatidylinositol 3' Kinase: One of the Effectors of Ras: Discussion (1996) (0)
Abstract IA04: Metabolic control of HCC initiation and progression (2022) (0)
Neutrophil-Derived IL-1 b I mpairs the Efficacy of NFk B Inhibitors against Lung Cancer Graphical (2016) (0)
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics (2021) (0)
Meeting on Signalling Networks in Immunity and Inflammation (2006) (0)
SIGNALING INFLAMMATION THROUGH IKK AND THE NF‐KAPPAB TRANSCRIPTION FACTORS: 175 (2004) (0)
Immunohistology of mouse spleens (2007) (0)
Structure and Regulation of the Human Metallothionein Gene Family (1985) (0)
ReviewMissing Pieces in the NF-B Puzzle stimulate the migration and maturation of lymphocytes (2002) (0)
Signalling in pattern recognition (WS-057) Chairpersons: Taro Kawai, Atsushi Matsuzawa (2010) (0)
Epithelial cell-intrinsic IKKβ expression regulates innate and adaptive immunity in the gut (42.4) (2007) (0)
The Human Metllothionein Gene Family: Structure and Expression by (2006) (0)
NF-κB and cancer (2015) (0)
The role of IL-6 and IL-23 in colitis associated cancer (88.30) (2009) (0)
Crystal structure of inhibitor ofk Bk inaseb (2011) (0)
The role of interleukin 23 in colitis-associated and spontaneous colon cancer: P-194. (2011) (0)
Abstract A066: NF-kB restricts inflammasome activation via elimination of damaged mitochondria (2016) (0)
Abstract PL03-03: ER stress and TNF signaling control the progression from simple steatosis to non-alcoholic steatohepatitis (NASH) (2015) (0)
Abstract SY40-01: Tumor elicited inflammation and malignant progression in colorectal cancer (2014) (0)
JAKi rips STAT 3 in cancer (0)
Proteine-kinase, oncoproteine (1994) (0)
Th2 Cytokine Gene Expression Amino-Terminal RING Motif to Regulate MEKK1 Binds HECT E3 Ligase Itch by Its (2009) (0)
Table of Contents (1995) (0)
Abstract 38: Saturated free fatty acids activate a c-Src-JNK1 axis within lipid rafts: Implications for the development of insulin resistance, obesity, and obesity-associated cancer (2010) (0)
Abstract 282: Endothelial-specific Deletion of Inhibitor of Kappa-B Kinase-{beta} (IKK-{beta}) (2007) (0)
Correction for Chen et al., Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia (2017) (0)
Regulation of IKK (2006) (0)
Abstract 2247: Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness (2019) (0)
Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
Correction for Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change, by Ewen (2010) (0)
Former Officers of the Harvey Society (2010) (0)
Previous CHANEL-CERIES. Research Award Winners: (2013) (0)
Activation of IKK by thymosin α1 requires the TRAF6 signalling pathway (2005) (0)
The Harvey Lectues: Delivered Under the Auspices of The Harvey Society of New York, 2006 -2007 (2010) (0)
Four violin sonatas (1971) (0)
chapter 7 – Cardiovascular Signaling Pathways (2004) (0)
Introduction to: Introduction (2003) (0)
Interleukin 23 and Tumor‐Elicited Inflammation in Colitis‐Associated and Spontaneous Colon Cancer: P‐202 (2012) (0)
The molecular basis for uv response of cultured human cells (1991) (0)
In Brief (1998) (0)
Cumulative Author Index (2002) (0)
The role of RANK-signaling in breast cancer development and metastasis (2008) (0)
45 Control of Tumour Progression and Metastasis by Lymphocyte-Produced Cytokines (2012) (0)
PIDDosome-SCAP Crosstalk Controls Diet Dependent Transition from Simple Steatosis to Steatohepatitis (2021) (0)
Abstract IA014: Collagen cleavage controls PDAC metabolism and malignancy via a DDR1-NRF2 cascade and mitochondrial biogenesis (2022) (0)
Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response (P1228) (2013) (0)
Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma (2022) (0)
Stress-Activated NRF 2-MD M 2 Cascade Controls Neoplastic Progression in Pancreas Graphical (2017) (0)
Abstract IA02: The intersection of inflammation, immunity, and cancer: From basic biology to translational research (2015) (0)
IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance (2023) (0)
Fructose stimulated de novo lipogenesis is promoted by inflammation (2020) (0)
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation (2018) (0)
The c-jun Gene and its Role in Signal Transduction (1989) (0)
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. (2023) (0)
NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia (2020) (0)
576: IL-17 SIGNALING REGULATES TNFRI-CASPASE2-SREBP1/2-DHCR7-MEDIATED DE NOVO LIPOGENESIS AND TUMORIGENESIS IN ALCOHOL-INDUCED LIVER DISEASE IN MICE (2022) (0)
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. (2023) (0)
Comprar NF-kB in Health and Disease | Karin, Michael | 9783642160165 | Springer (2011) (0)
Stress of Life: Stress and Adaptation from Molecules to Man. International Congress of Stress, an Interdisciplinary Discussion Commemorating the 90th Birth Anniversary of Hans Selye International Congress of Stress, an Interdisciplinary Discussion Commemorating the 90th Birth Anniversary of Hans Sel (1996) (0)
Nuclear Factor‐κB in Apoptosis and Tumorigenesis (2008) (0)
FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness (2023) (0)
Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells (2023) (0)
Abstract 2393: PDAC cells release BAG3 that activates a paracrine loop with stromal macrophages (2015) (0)
Biological Roles of Map K Cascades in Breast Cancer Cells (1997) (0)
1050 MicroRNA-9 Inflammatory Circuit Regulates Hepatocellular Oncogenesis (2012) (0)
Announcing MedComm – Future Medicine : A forum to bring the future to the present (2022) (0)
The role of IL-1β on IKKβ inhibitors induced neutrophilia (116.4) (2011) (0)
Is NF- (cid:107) B the sensor of oxidative stress? (1999) (0)
United States Patent ( 19 ) Karin 54 MAMMALIAN METALLOTHIONEIN (2017) (0)
DNA Binding Proteins and Their Roles in Controlling Tissue Specific Gene Expression and Responses to Second Messengers (1988) (0)
Abstract 5533: Imaging stromal recruitment during liver metastasis formation in the GFP-MUP-uPA mouse (2012) (0)
Complexity in cancer-host crosstalk : extended abstracts for the 48th International Symposium of the Princess Takamatsu Cancer Research Fund : November 7-9, 2017 Tokyo, Japan (2018) (0)
Signaling by innate immune receptors (2009) (0)
Directed yeast two hybrid screening for MEKK1 interaction partners (2007) (0)
In vitro class switching staining for flow cytometry (2006) (0)
Erratum: IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulinsignalling cascade (Biochemical Journal (2012) 442 (723-732)) (2013) (0)
IL-17 Signaling in Steatotic Hepatocytes and Macrophages Promotes Alcoholic Liver Disease-induced Hepatocellular Carcinoma (2020) (0)

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