Michael Klagsbrun

Michael Klagsbrun's AcademicInfluence.com Rankings

Michael Klagsbrun

Biology

#4663

World Rank

#6933

Historical Rank

Cell Biology

#119

World Rank

#124

Historical Rank

Molecular Biology

#375

World Rank

#382

Historical Rank

biology Degrees

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Biology

Michael Klagsbrun's Degrees

PhD Molecular and Cellular Biology Stanford University

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Michael Klagsbrun's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor (1998) (2519)
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor (1991) (2343)
Angiogenic factors. (1987) (2162)
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF (1991) (1136)
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. (1987) (1015)
A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane. (1988) (941)
Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. (1984) (890)
Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose. (1986) (830)
Regulators of angiogenesis. (1991) (762)
Vascular endothelial growth factor and its receptors. (1996) (636)
Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. (1989) (578)
A dual receptor system is required for basic fibroblast growth factor activity (1991) (558)
Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. (1994) (551)
Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma (1991) (534)
Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility (1999) (518)
VEGF165 mediates formation of complexes containing VEGFR‐2 and neuropilin‐1 that enhance VEGF165‐receptor binding (2002) (489)
High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. (1989) (458)
Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities (2004) (440)
Heparin-binding EGF-like growth factor. (1997) (430)
Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. (1995) (427)
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis (2002) (404)
Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds (1988) (399)
Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border (1998) (397)
Activation of HER4 by heparin‐binding EGF‐like growth factor stimulates chemotaxis but not proliferation (1997) (373)
Basic fibroblast growth factor fused to a signal peptide transforms cells (1988) (372)
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. (1994) (372)
Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF via Its Exon 7-encoded Domain (*) (1996) (352)
The fibroblast growth factor family: structural and biological properties. (1989) (351)
Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate (1993) (349)
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function (2003) (348)
The fibroblast growth factor family. (1991) (342)
Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site* (1997) (342)
Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. (1992) (339)
Controlled and modulated release of basic fibroblast growth factor. (1991) (336)
Neuropilin‐1 expression by tumor cells promotes tumor angiogenesis and progression (2000) (328)
Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity (*) (1995) (323)
Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. (1993) (322)
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity. (2000) (317)
Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1* (1999) (313)
T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells. (1994) (313)
Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. (2012) (312)
The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor (1995) (307)
Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. (2004) (303)
Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis (1991) (282)
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. (1995) (281)
Heparin‐binding EGF‐like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up‐regulates functional receptors and diphtheria toxin sensitivity. (1994) (269)
Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain* (2002) (255)
Neuropilins in neoplasms: expression, regulation, and function. (2006) (251)
Tumor Necrosis Factor-α Regulates Expression of Vascular Endothelial Growth Factor Receptor-2 and of Its Co-receptor Neuropilin-1 in Human Vascular Endothelial Cells* (1998) (248)
Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted (1987) (237)
Purification and characterization of heparin-binding endothelial cell growth factors. (1986) (236)
A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. (2005) (229)
The role of neuropilin in vascular and tumor biology. (2002) (227)
Biological and biochemical properties of fibroblast growth factors. Implications for the pathogenesis of atherosclerosis. (1989) (225)
A Novel Juxtamembrane Domain Isoform of HER4/ErbB4 (1997) (222)
Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. (2006) (218)
Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish (2002) (218)
Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor (1985) (216)
Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. (1986) (215)
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities (1984) (211)
Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma (2013) (209)
Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. (1996) (208)
Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions (1993) (203)
Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (2000) (199)
The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading* (1999) (192)
Heparin-Binding Epidermal Growth Factor-Like Growth Factor: Hypoxia-Inducible Expression In Vitro and Stimulation of Neurogenesis In Vitro and In Vivo (2002) (190)
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165 * (1997) (189)
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro (2008) (188)
Isolation, characterization, and localization of heparin-binding growth factors in the heart. (1990) (185)
Angiogenesis is stimulated by a tumor‐derived endothelial cell growth factor (1985) (185)
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1 (1997) (184)
Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors. (1985) (183)
Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis (2008) (182)
Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase (1999) (180)
Selective Binding of VEGF to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells (*) (1996) (180)
Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells (1989) (179)
Forty-Year Journey of Angiogenesis Translational Research (2011) (178)
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. (2008) (176)
Isolation and characterization of a macrophage-derived heparin-binding growth factor. (1990) (174)
A Natural ErbB4 Isoform That Does Not Activate Phosphoinositide 3-Kinase Mediates Proliferation but Not Survival or Chemotaxis* (2000) (173)
Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues. (1993) (167)
VEGF/VPF: The angiogenesis factor found? (1993) (166)
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. (2011) (166)
Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. (2004) (165)
The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-α, Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4* (1996) (165)
Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors. (2009) (160)
Tumor angiogenesis activity in cells grown in tissue culture. (1976) (160)
Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. (1997) (159)
Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1. (2003) (158)
A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities. (2005) (156)
T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role. (1995) (156)
The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix. (1990) (155)
Molecular angiogenesis. (1999) (151)
Differential expression of VEGF isoforms and VEGF164‐specific receptor neuropilin‐1 in the mouse uterus suggests a role for VEGF164 in vascular permeability and angiogenesis during implantation (2000) (148)
Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. (1999) (139)
Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts. (1978) (138)
Heparin-binding epidermal growth factor-like growth factor expression in cultured fetal human vascular smooth muscle cells. Induction of mRNA levels and secretion of active mitogen. (1993) (132)
A family of angiogenic peptides (1987) (129)
Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. (2007) (128)
Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes. (1994) (126)
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin‐binding EGF‐like growth factor independently of protein kinase C (1998) (125)
N‐arginine dibasic convertase is a specific receptor for heparin‐binding EGF‐like growth factor that mediates cell migration (2001) (122)
Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing (1996) (121)
Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta. (1988) (121)
Cartilage to bone—Angiogenesis leads the way (1999) (118)
Sertoli cells contain a mitogenic polypeptide. (1980) (114)
The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage. (1977) (113)
Purification of cartilage-derived growth factor by heparin affinity chromatography. (1985) (113)
Human and bovine milk contain different sets of growth factors. (1984) (113)
Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin. (1990) (113)
Mediators of angiogenesis: the biological significance of basic fibroblast growth factor (bFGF)-heparin and heparan sulfate interactions. (1992) (113)
Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. (2001) (112)
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy (2015) (112)
Isolated tumor endothelial cells maintain specific character during long-term culture. (2010) (112)
Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors (1989) (111)
Large-scale preparation of chondrocytes. (1979) (110)
Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells (2005) (110)
Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium. (1995) (109)
Neuropilin is a Mediator of Angiogenesis (2004) (108)
Calcification of multipotent prostate tumor endothelium. (2008) (107)
Human vascular endothelial cells in culture. Lack of response to serum growth factors. (1976) (106)
Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases. (1987) (102)
Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. (1998) (100)
ABL2/ARG Tyrosine Kinase Mediates SEMA3F-induced RhoA Inactivation and Cytoskeleton Collapse in Human Glioma Cells* (2008) (99)
Activation of Syndecan-1 Ectodomain Shedding by Staphylococcus aureus α-Toxin and β-Toxin* (2004) (97)
Temporal, differential and regional expression of mRNA for basic fibroblast growth factor in the developing and adult rat brain. (1991) (96)
Targeting endothelial and tumor cells with semaphorins (2007) (96)
AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation (2015) (95)
Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus (1991) (95)
Fibroblast growth factor (FGF) levels in the developing rat brain. (1990) (94)
AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. (1999) (92)
Differential regulation of heparin-binding epidermal growth factor-like growth factor in the adult ovariectomized mouse uterus by progesterone and estrogen. (1994) (91)
Neuropilin-2 Expression Promotes TGF-β1-Mediated Epithelial to Mesenchymal Transition in Colorectal Cancer Cells (2011) (89)
Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases (1997) (85)
Modulation of Wound Repair by Members of the Fibroblast Growth Factor Family (1988) (84)
Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (2010) (83)
The chick chorioallantoic membrane as a model system for the study of tissue invasion by viral transformed cells (1976) (80)
Netrin-1 Promotes Glioblastoma Cell Invasiveness and Angiogenesis by Multiple Pathways Including Activation of RhoA, Cathepsin B, and cAMP-response Element-binding Protein* (2012) (80)
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis (2012) (79)
Neuropilin‐1 expression in osteogenic cells: Down‐regulation during differentiation of osteoblasts into osteocytes (2001) (79)
Heparin-like Molecules on the Cell Surface Potentiate Binding of Diphtheria Toxin to the Diphtheria Toxin Receptor/Membrane-anchored Heparin-binding Epidermal Growth Factor-like Growth Factor (*) (1995) (78)
Biosynthesis and processing by phorbol ester of the cells surface-associated precursor form of heparin-binding EGF-like growth factor. (1994) (77)
Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension. (1993) (76)
The Fibroblast Growth Factor Family An Overview (1991) (74)
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects (2003) (72)
Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) is a Mediator of Multiple Physiological and Pathological Pathways (2004) (71)
Purification of a cartilage-derived growth factor. (1980) (71)
Expression of acidic and basic fibroblast growth factors in human and bovine vascular smooth muscle cells. (1990) (71)
Growth factor expression after stroke. (1990) (71)
Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells. (1996) (71)
Neuron Restrictive Silencer Factor NRSF/REST Is a Transcriptional Repressor of Neuropilin-1 and Diminishes the Ability of Semaphorin 3A to Inhibit Keratinocyte Migration* (2006) (71)
Bovine colostrum supports the serum-free proliferation of epithelial cells but not of fibroblasts in long-term culture (1980) (69)
Mitogenic polypeptide of the mammalian seminiferous epithelium: biochemical characterization and partial purification (1983) (69)
Vascular physiology. A family of angiogenic peptides. (1987) (68)
Endothelial cell surface alkaline phosphatase activity is induced by IL-6 released during wound repair. (1997) (68)
Regulators of angiogenesis: Stimulators, inhibitors, and extracellular matrix (1991) (66)
Glucocorticoid inhibits thrombin-induced expression of platelet-derived growth factor A-chain and heparin-binding epidermal growth factor-like growth factor in human aortic smooth muscle cells. (1993) (64)
Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo. (2010) (64)
Wound fluid-derived heparin-binding EGF-like growth factor (HB-EGF) is synergistic with insulin-like growth factor-I for Balb/MK keratinocyte proliferation. (1996) (62)
Neuropilin‐1a is involved in trunk motor axon outgrowth in embryonic zebrafish (2005) (60)
αA-crystallin expression prevents γ-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens (2006) (59)
Developmental changes in fibroblast growth factor in the chicken embryo limb bud. (1988) (58)
Neuropilins: novel targets for anti-angiogenesis therapies. (2007) (57)
An evolutionary study of the methylation of transfer and ribosomal ribonucleic acid in prokaryote and eukaryote organisms. (1973) (57)
Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells (1991) (57)
Glucose Transporter 1‐Positive Endothelial Cells in Infantile Hemangioma Exhibit Features of Facultative Stem Cells (2015) (56)
Purification and characterization of transmembrane forms of heparin-binding EGF-like growth factor. (1994) (56)
A Mutated Soluble Neuropilin-2 B Domain Antagonizes Vascular Endothelial Growth Factor Bioactivity and Inhibits Tumor Progression (2010) (55)
Endothelial progenitor cell sprouting in spheroid cultures is resistant to inhibition by osteoblasts: A model for bone replacement grafts (2005) (55)
Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine (2008) (54)
Purification of 18- and 22-kDa forms of basic fibroblast growth factor from rat cells transformed by the ras oncogene. (1989) (53)
Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2 (2011) (53)
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells. (2008) (53)
Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. (2012) (53)
Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus alpha-toxin and beta-toxin. (2004) (52)
The serum‐free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period (1981) (51)
Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. (2014) (51)
Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. (1997) (50)
The role of growth factors in vascular cell development and differentiation. (1995) (49)
Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. (2010) (48)
Site-directed Mutagenesis in the B-Neuropilin-2 Domain Selectively Enhances Its Affinity to VEGF165, but Not to Semaphorin 3F* (2007) (48)
Advanced glycation end-products suppress neuropilin-1 expression in podocytes. (2009) (48)
Semaphorin 3F forms an anti‐angiogenic barrier in outer retina (2013) (48)
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription (2013) (47)
Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo (2015) (47)
The serum-free growth of Balb/c 3T3 cells in medium supplemented with bovine colostrum. (1979) (46)
VEGF is required for the maintenance of dorsal root ganglia blood vessels but not neurons during development (2004) (46)
Sequestration and Release of Basic Fibroblast Growth Factor a (1991) (46)
GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2 (2013) (45)
Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. (2004) (44)
Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin. (1989) (44)
Vascular endothelial growth factor and its receptors in embryonic zebrafish blood vessel development. (2004) (40)
Soluble neuropilin targeted to the skin inhibits vascular permeability (2005) (40)
The identification and clinical implications of human breast milk mitogen. (1979) (38)
Serum-free growth of normal and transformed fibroblasts in milk: differential requirements for fibronectin (1981) (36)
Heparin-binding angiogenesis factors: detection by immunological methods. (1987) (35)
VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats (2013) (35)
Growth Factors With Heparin Binding Affinity In Human Synovial Fluid (1987) (35)
Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity. (1999) (34)
Subcellular distribution of basic fibroblast growth factor in human hepatoma cells. (1991) (34)
Smooth muscle cell and endothelial cell growth factors. (1993) (33)
Species-specific high molecular weight forms of basic fibroblast growth factor. (1990) (32)
The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis (2015) (32)
Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency. (2016) (32)
Hyaluronan-dependent pericellular coats of chick embryo limb mesodermal cells: induction by basic fibroblast growth factor. (1991) (30)
Purification and characterization of a bovine colostrum-derived growth factor. (1987) (30)
VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells (2015) (30)
Increased smooth muscle contractility in mice deficient for neuropilin 2. (2012) (29)
Inhibition of Endothelial Cell Growth by Macrophage-like U-937 Cell-derived Oncostatin M, Leukemia Inhibitory Factor, and Transforming Growth Factor β1* (1996) (29)
A cartilage‐derived growth factor enhances hyaluronate synthesis and diminishes sulfated glycosaminoglycan synthesis in chondrocytes (1986) (29)
The Membrane Protein CD 9 / DRAP 27 Potentiates the Juxtacrine Growth Factor Activity of the Membrane-anchored Heparin-binding EGF-like Growth Factor (2002) (28)
Osteoarthritis. Emerging evidence for cell interactions in the breakdown and remodeling of cartilage. (1985) (28)
Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). (1995) (28)
[4] Purification of polypeptide growth factors from milk (1987) (28)
Autocrine regulation of cell growth and transformation by basic fibroblast growth factor (1990) (27)
Increased levels of basic fibroblast growth factor (bFGF) following focal brain injury. (1990) (26)
Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo (2016) (26)
Heparan sulfate degradation in tumor cell invasion and angiogenesis. (1988) (26)
Semaphorin-induced cytoskeletal collapse and repulsion of endothelial cells. (2008) (26)
Characterization of the neuropilin‐1 promoter; gene expression is mediated by the transcription factor Sp1 (2003) (26)
Methylated amino acids in the proteins of bacterial and mammalian cells. (1975) (25)
Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively. (1999) (25)
Heparin-binding EGF-like growth factor synthesis by smooth muscle cells. (1994) (25)
The role of fibroblast growth factors and related oncogenes in tumor growth. (1992) (25)
Regulation of basic fibroblast growth factor mRNA expression in rat C6 glioma cells. (1993) (24)
Macrophages secrete a heparin-binding inhibitor of endothelial cell growth. (1991) (23)
An endogenous ovarian growth factor which stimulates BALB/3T3 and granulosa cell proliferation. (1983) (23)
Presence of heparin binding growth factor in mouse bladder tumors and urine from mice with bladder cancer. (1986) (23)
Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus (2016) (22)
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). (2002) (22)
Biosynthesis and storage of basic fibroblast growth factor (bFGF) by endothelial cells: implication for the mechanism of action of angiogenesis. (1988) (22)
Characterization of the promoter for the human antisense fibroblast growth factor‐2 gene; Regulation by Ets in Jurkat T cells (1999) (20)
Tumor Angiogenesis: Effect on Tumor Growth and Immunity (1975) (20)
The contrast between the methylation of transfer ribonucleic acid in vivo and in vitro by normal and SV40 transformed 3T3 cells. (1972) (19)
Angiogenesis: Mechanisms and Pathobiology (1987) (19)
Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration (2014) (19)
Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain. (1995) (18)
Carboxyl‐terminal truncation of leucine76 converts heparin‐binding EGF‐like growth factor from a heparin‐enhancible to a heparin‐suppressible growth factor (1995) (18)
Purification of endothelial cell growth factors by heparin affinity chromatography. (1987) (18)
Growth factor- and dexamethasone-induced proteins in Swiss 3T3 cells. Relationship to DNA synthesis. (1985) (18)
Angiogenic factors: regulators of blood supply-side biology. FGF, endothelial cell growth factors and angiogenesis: a keystone symposium, Keystone, CO, USA, April 1-7, 1991. (1991) (18)
Semaphorin 3E, an exception to the rule. (2010) (17)
The heparin-binding domain of heparin-binding EGF-like growth factor can target Pseudomonas exotoxin to kill cells exclusively through heparan sulfate proteoglycans. (1994) (16)
Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. (2014) (16)
Differences in the methylation of transfer ribonucleic acid in vitro by the mitochondrial and cytoplasmic transfer ribonucleic acid methylases of HeLa cells. (1973) (15)
Characterization of growth factors in human cartilage (1982) (15)
Id 2 Promotes Tumor Cell Migration and Invasion through Transcriptional Repression of Semaphorin 3 F (2010) (14)
Interaction of basic fibroblast growth factor with bovine growth plate chondrocytes (1992) (14)
Role of neuropilins and semaphorins in angiogenesis and cancer. (2002) (14)
Purification and assay of intact human basic fibroblast growth factor using heparin-sepharose chromatography (1986) (14)
Stimulation of increased capillary endothelial cell motility by chondrosarcoma cell-derived factors. (1983) (13)
Changes in the methylation of transfer RNA in vaccinia infected HeLa cells. (1971) (12)
Tumor Endothelial Cells Join the Resistance (2009) (12)
The mitogenic activity of human breast milk. (1979) (12)
Purification of polypeptide growth factors from milk. (1987) (11)
Obituary: M. Judah Folkman (1933–2008) (2008) (11)
Angiogenesis and Cancer: AACR Special Conferene in Cancer Research (1999) (10)
Implications for the Pathogenesis of Atherosclerosis (2005) (10)
Neuropilins (2007) (9)
Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins. (2015) (9)
Use of size-exclusion and ion-exchange high-performance liquid chromatography for the isolation of biologically active growth factors. (1983) (9)
In vitro synthesis of T4 bacteriophage head protein using polysomes of T4-infected Escherichia coli. (1970) (9)
The decreased synthesis of chondroitin sulfate-containing extracellular proteoglycans by SV40 transformed Balb/c 3T3 cells. (1976) (9)
Tumor endothelial cells have features of adult stem cells (2009) (8)
Isolation of growth factors from human milk. (1984) (7)
[30] Purification of Cartilage-Derived Growth Factors (1987) (7)
Use of a 3T3 cell growth factor assay for the delineation and characterization of humoral trophic factors involved in intestinal adaptation in the rat. (1986) (6)
Interaction of Heparin-Binding EGF-Like Growth Factor with Multiple Receptors (1997) (6)
Human Milk-Derived Growth Factor Prevents Duodenal Ulcer Formation (1985) (5)
Novel svVEGF isoforms from Macrovipera lebetina venom interact with neuropilins. (2009) (5)
Partial characterization of a cell motility factor from human urine. (1985) (5)
A New Method for purifying Heparin‐binding Growth Factors a (1989) (5)
The Methylation of Transfer and Ribosomal Ribonucleic Acid in Human Fibroblasts: Normal Methylation of Ribonucleic Acid in Cystic Fibrosis (1974) (5)
Angiogenesis and cancer: AACR special conference in cancer research. American Association for Cancer Research. (1999) (4)
Interferon g Induces Prostaglandin G/H Synthase-2 through an Autocrine Loop via the Epidermal Growth Factor Receptor in Human Bronchial Epithelial Cells (1997) (4)
Stimulation of amniotic fluid cell growth by cartilage growth factor. (1980) (4)
Subcellular Distribution of Multiple Molecular Weight Forms of bFGF in Hepatoma Cells (1991) (4)
Tumor Endothelial Cell Abnormalities (2008) (4)
Endothelial Biomedicine: Neuropilins: Receptors Central to Angiogenesis and Neuronal Guidance (2007) (3)
Angiogenesis : biology and pathology (2012) (3)
The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance (2016) (3)
Netrin-1 Is a Novel Molecule That Elicits Chemoattraction of Activated CD4+ T-Lymphocytes Via Interactions With Neogenin.: Abstract# 2899 (2014) (2)
Purification of cartilage-derived growth factors. (1987) (2)
Heparin-Binding Epidermal Growth Factor-like Growth Factor (HB-EGF) (2003) (2)
Polysomal distribution of late bacteriophage T4 messenger RNA. (1970) (2)
(cid:2) A-crystallin expression prevents (cid:4) -crystallin insolubility and cataract formation in the zebrafish cloche mutant lens (2006) (2)
Purification and characterization of a novel vascular endothelial cell growth inhibitor secreted by macrophage-like U-937 cells. (1999) (2)
Human endothelial cells synthesize fibroblast growth factor and transforming growth factor beta (1987) (2)
AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. (1999) (2)
Neuropilin-2 and epithelial to mesenchymal transition in colorectal cancer cells. (2010) (2)
GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2 (2013) (2)
Cell interactions in osteoarthritis: proposed role for cartilage-derived growth factor. (1983) (2)
Oncogenic Transformation by Basic Fibroblast Growth Factor (1989) (2)
Expression of mRNA encoding basic fibroblast growth factor and fibroblast growth factor receptor 1 in developing and adult rat brain (1992) (1)
Effects of Human Milk Growth Factor on Gastric and Duodenal Mucus Formation (1987) (1)
Differential effects of cartilage-derived growth factor stimulation of collagen secretion by bovine aortic and microvascular endothelial cells. (1987) (1)
Activation of mechanosensitive ion channel TRPV4 promotes normalization of tumor vasculature and improves cancer therapy (893.12) (2014) (1)
Karine secreting semaphorin 3 A Ischemic neurons prevent vascular regeneration of neural tissue (2011) (1)
Netrin-1 induces Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of pediatric medulloblastoma patients (2014) (1)
Construction and expression of transforming gene resulting from fusion of basic fibroblast growth factor gene with signal peptide sequence. (1991) (1)
NASA contributions to bioinstrumentation systems - A survey (1968) (1)
PROLIFERATION OF SERTOLI CELLS IS INDUCED BY A GROWTH FACTOR ISOLATED FROM THE MAMMALIAN SEMINIFEROUS EPITHELIUM (1981) (1)
Research Highlights (2004) (0)
The Structural and Biological Properties of Heparin-Binding Egf- Like Growth Factor (HB-EGF) (1993) (0)
The Effect of SEMA3F on Lymphangiogenesis in the Cornea (2008) (0)
TRPV4 channels regulate tumor angiogenesis through the modulation of Rho‐dependent tumor endothelial cell mechanosensitivity (2012) (0)
This information is current as Response In Vivo Cells In Vitro and Elicits a Proinflammatory T + Netrin-1 Augments Chemokinesis in CD 4 (2016) (0)
Differential expression patterns of Semaphorin 3F in the murine and human retina and its role in choroidal neovascularization (2013) (0)
kinase family mediate vascular development in the zebrafish Duplicate VegfA genes and orthologues of the KDR receptor tyrosine (2013) (0)
PLACENTAL GROWTH FACTOR/NEUROPILIN 1 SIGNALING IS A THERAPEUTIC TARGET IN PEDIATRIC MEDULLOBLASTOMA (2013) (0)
377 Oncogenic role of neuropilin-2 (2010) (0)
Targeting EGFR activity in tumor-derived endothelial cells. (2006) (0)
11: Stimulation of DNA Synthesis in Cultured Pibroblasts and Chondrocytes by a Cartilage-Derived Growth Factor (1976) (0)
TumorAngiogenesisActivityin Cells Grown in Tissue Culture1 (1976) (0)
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis (2012) (0)
Hepatoma-Derived Growth Factor (HDGF): A New Heparin-Binding Growth Factor Identified in Leiomyomas and Normal Myometrium (1998) (0)
VEGF-A/Neuropilin signal activates RhoA and promotes cancer growth and metastasis. (2015) (0)
Growth Factor-and Dexamethasone-induced Proteins in Swiss 3 T 3 Cells (2001) (0)
secreting semaphorin 3A Ischemic neurons prevent vascular regeneration of neural tissue by (2011) (0)
Michael Klagsbrun by Normal and SV 40 Transformed 3 T 3 Cells Vitro in and in Vivo The Contrast between the Methylation of Transfer Ribonucleic Acid (2002) (0)
News and notices (2005) (0)
Neuropilins, receptors for the VEGF and semaphorin families, link angiogenesis and axon guidance (2006) (0)
Tumor-associated Endothelial Cells as Targets of Anti-angiogenic Therapy (2006) (0)
Regulation of the syndecan family of matrix and growth factor co-receptors. Detection of an inductive activity released during wound repair (1993) (0)
Invasiveness and Angiogenesis by Multiple Netrin-1 Promotes Glioblastoma Cell Molecular Bases of Disease : (2013) (0)
ACTIVATOR PROTEIN-1 MEDIATES STRETCH-ACTIVATED HEPARIN-BINDING EGF-LIKE GROWTH FACTOR EXPRESSION IN BLADDER SMOOTH MUSCLE CELLS (1999) (0)
A Novel Immunomodulatory Function for Semaphorin3F and Neuropilin-2 in Allograft Rejection.: Abstract# 1491 (2014) (0)
Neuropilin 2 Deficiency Prolongs Skin Inflammation and Edema (2016) (0)
Storage of Heparin-Binding Endothelial Cell Growth Factors in the Cornea: a New Mechanism for Corneal Neovascularization (1987) (0)
12 – ras Transformation of 3T3 Cells Induces Basic Fibroblast Growth Factor Synthesis in Vitro and in Vivo (1991) (0)
Characterisation of humoral trophic factors involved in intestinal adaptation using a 3T3 cell growth factor assay. (1987) (0)
Bronchial Epithelial Cells As A Source Of Angiogenic Mediators In The Airway Remodeling Of Asthma (2012) (0)
Judah Folkman, M.D. February 24, 1933–January 14, 2008 (2008) (0)
Abstract IA17: Targeting placental growth factor/ neuropilin-1 pathway inhibits growth and spread of medulloblastoma (2014) (0)
CHROMOSOMAL ABNORMALITIES OF TUMOR ENDOTHELIAL CELLS IN HUMAN RENAL CELL CARCINOMA (2008) (0)
Cell killing effect of heparin-binding EGF-like growth factor Pseudomonas exotoxin on human hepatoma cells (1996) (0)
Abstract 430: MiRNA profiling of prostate cancer cell-derived large oncosomes identifies a signature of invasion and metastasis (2012) (0)
TARGET CELL ASSAY FOR HUMORAL TROPHIC FACTORS AFTER MABDOMINAL SURGERY (1984) (0)
Effect of rhHB-EGF on the expression of hydrocephalus-related genes in vitro (2009) (0)
Purification of Basic Fibroblast Growth Factor by Heparin Affinity (2009) (0)
ROLE OF THE MICROVASCULATURE IN SHAPING THE INTRAGRAFT MICROENVIRONMENT : A PARADIGM FOR UNDERSTANDING LOCAL IMMUNOREGULATION AND TOLERANCE (2016) (0)
Novel Effects of Semaphorin 3F On the Regulation of Intracellular PI3K-Akt Signaling.: Abstract# B1157 (2014) (0)
AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation (2014) (0)
Heparin Binding Growth Factor (2020) (0)
Large Scale Purification of a Human Hepatoma Derived Endothelial Cell Growth Factor (1987) (0)
Abstract 1308: Cytogenetic abnormalities of tumor endothelial cells in human malignant tumors (2010) (0)
Molecular Cancer esearch iogenesis , Metastasis , and the Cellular Microenvironment utated Soluble Neuropilin-2 B Domain Antagonizes cular Endothelial Growth Factor Bioactivity and R bits Tumor Progression (2010) (0)
Method of purifying endothelial cell growth factors using immobilized heparin (1990) (0)

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