Michael Marletta
#10,454
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American biochemist
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Michael Marlettabiology Degrees
Biology
#577
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#1018
Historical Rank
#324
USA Rank
Biochemistry
#177
World Rank
#226
Historical Rank
#94
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Biology
Michael Marletta's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Michael Marletta Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michael A. Marletta is an American biochemist. He was born in Rochester, New York, the son of Italian immigrants. He graduated from the State University of New York at Fredonia in 1973 with an A.B. degree in biology and chemistry, and from the University of California, San Francisco in 1978 with a Ph.D. degree in pharmaceutical chemistry, where he studied with George Kenyon. He was a postdoctoral fellow with Christopher T. Walsh at MIT from 1978-1980 and continued as a faculty member at MIT from 1980-1987 whereupon he joined the faculty of the University of Michigan, Ann Arbor. He was John G. Searle Professor of Medicinal Chemistry in the college of pharmacy and professor of biological chemistry at the University of Michigan. In 2001, he moved to the University of California, Berkeley to assume roles as Aldo DeBenedictis Distinguished Professor of Chemistry and professor of biochemistry and molecular biology, and served as the chair of the department of chemistry from 2005 until 2010. He was a Howard Hughes Medical Institute Investigator. From January 2012 to August 2014, Marletta was president and CEO of The Scripps Research Institute in La Jolla, California, succeeding Richard Lerner.
Michael Marletta's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. (1988) (1574)
- Nitric oxide synthase structure and mechanism. (1993) (1217)
- Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. (1985) (1117)
- Guanylate cyclase and the .NO/cGMP signaling pathway. (1999) (990)
- Nitric oxide synthase: Aspects concerning structure and catalysis (1994) (854)
- Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. (1987) (687)
- Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. (1987) (649)
- Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. (1994) (615)
- Nitric oxide synthase is a cytochrome P-450 type hemoprotein. (1992) (598)
- Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. (1989) (595)
- Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue (2004) (561)
- Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa. (2011) (546)
- Tissue injury caused by deposition of immune complexes is L-arginine dependent. (1991) (439)
- Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. (1991) (438)
- Nitric oxide: biosynthesis and biological significance. (1989) (408)
- Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases. (2012) (401)
- Structure and regulation of soluble guanylate cyclase. (2012) (397)
- Synthesis of nitrite and nitrate in murine macrophage cell lines. (1987) (333)
- Polymerization of phenols catalyzed by peroxidase in nonaqueous media (1987) (318)
- Nitric-oxide synthase assays. (1994) (316)
- A molecular basis for nitric oxide sensing by soluble guanylate cyclase. (1999) (307)
- Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. (1996) (293)
- Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa (2009) (290)
- Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine (2005) (274)
- Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases (2009) (271)
- Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. (1986) (256)
- Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases. (2012) (256)
- Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. (2004) (246)
- Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents. (1988) (241)
- Cellulose degradation by polysaccharide monooxygenases. (2015) (241)
- Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens. (1994) (238)
- A Distributed Chemosensory Circuit for Oxygen Preference in C. elegans (2006) (229)
- Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. (2013) (229)
- Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. (2012) (224)
- Nitric oxide and the lung. (1994) (223)
- Inhibition of soluble guanylate cyclase by ODQ. (2000) (215)
- Nitrosation of amines by stimulated macrophages. (1987) (213)
- Nitric oxide signaling: no longer simply on or off. (2006) (207)
- A family of starch-active polysaccharide monooxygenases (2014) (206)
- Catalysis by nitric oxide synthase. (1998) (204)
- Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. (2000) (197)
- Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. (2014) (191)
- Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. (1999) (191)
- Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine (1997) (184)
- N-terminal processing of proteins exported by malaria parasites. (2008) (177)
- A molecular basis for NO selectivity in soluble guanylate cyclase (2005) (175)
- Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity. (1992) (167)
- Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. (2004) (167)
- NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase. (1993) (164)
- Approaches toward selective inhibition of nitric oxide synthase. (1994) (162)
- Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand. (1998) (162)
- Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. (1998) (156)
- Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. (2012) (155)
- Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells (2007) (154)
- Lung sources and cytokine requirements for in vivo expression of inducible nitric oxide synthase. (1995) (152)
- Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase. (1995) (151)
- Mycobacteria Inhibit Nitric Oxide Synthase Recruitment to Phagosomes during Macrophage Infection (2004) (149)
- Assembly of the covalent linkage between lipoic acid and its cognate enzymes. (2003) (148)
- Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP. (2005) (142)
- Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with Resonance raman spectroscopy. (1996) (132)
- A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase (2009) (127)
- Biochemistry of soluble guanylate cyclase. (2009) (120)
- Subcellular Targeting and Differential S-Nitrosylation of Endothelial Nitric-oxide Synthase* (2006) (118)
- H‐NOX regulation of c‐di‐GMP metabolism and biofilm formation in Legionella pneumophila (2010) (117)
- Localization of the heme binding region in soluble guanylate cyclase. (1997) (117)
- Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from Escherichia coli. (2005) (117)
- Reactivity of O2 versus H2O2 with polysaccharide monooxygenases (2018) (115)
- Unraveling the biological significance of nitric oxide. (1990) (114)
- Flavonoid inhibition of the human neutrophil NADPH-oxidase. (1984) (113)
- Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide. (1998) (112)
- Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: The simple NO-binding model is incorrect (2002) (112)
- Nitric oxide complexes of inducible nitric oxide synthase: spectral characterization and effect on catalytic activity. (1995) (112)
- Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase. (1995) (110)
- Synthesis and action of nitric oxide in rat glomerular mesangial cells. (1991) (109)
- Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors. (2005) (106)
- H-NOX–mediated nitric oxide sensing modulates symbiotic colonization by Vibrio fischeri (2010) (106)
- Quantitative proteomic approach for cellulose degradation by Neurospora crassa. (2011) (102)
- Probing the function of heme distortion in the H-NOX family. (2008) (101)
- Inactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine. (1991) (101)
- Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin. (1985) (98)
- Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins. (2005) (97)
- The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase (2008) (96)
- Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. (2013) (95)
- Modulating heme redox potential through protein-induced porphyrin distortion. (2010) (94)
- Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobin. (1998) (90)
- Characterization of neuronal nitric oxide synthase and a C415H mutant, purified from a baculovirus overexpression system. (1994) (90)
- Heme stoichiometry of heterodimeric soluble guanylate cyclase. (1995) (89)
- Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain. (2005) (88)
- Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studies. (2000) (88)
- Molecular architecture of mammalian nitric oxide synthases (2014) (86)
- Nitric oxide synthase: function and mechanism. (1993) (83)
- Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxide. (2007) (83)
- Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites. (1995) (83)
- Nitric Oxide Signaling (2013) (82)
- Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages. (1992) (79)
- The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase. (2017) (79)
- Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation (2013) (79)
- S-Nitrosation and regulation of inducible nitric oxide synthase. (2005) (76)
- Analytical and preparative high-performance liquid chromatography separation of flavin and flavin analog coenzymes. (1980) (75)
- Structural insights into the role of iron–histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins (2014) (74)
- Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state. (2010) (73)
- Characterization of functional heme domains from soluble guanylate cyclase. (2005) (71)
- LIPOIC ACID BIOSYNTHESIS : LIPA IS AN IRON-SULFUR PROTEIN (1999) (71)
- Peroxidases depolymerize lignin in organic media but not in water. (1986) (70)
- A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation (2009) (69)
- Nitric oxide-induced conformational changes in soluble guanylate cyclase. (2014) (69)
- Site-specific and redox-controlled S-nitrosation of thioredoxin (2011) (68)
- Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer. (2002) (67)
- Spectroscopic characterization of the heme-binding sites in Plasmodium falciparum histidine-rich protein 2. (1999) (66)
- NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum (2009) (66)
- Characterization of the inactivation of nitric oxide synthase by NG-methyl-L-arginine: evidence for heme loss. (1994) (65)
- Physiological activation and deactivation of soluble guanylate cyclase. (2018) (62)
- The ferrous heme of soluble guanylate cyclase: formation of hexacoordinate complexes with carbon monoxide and nitrosomethane. (1995) (62)
- The framework of polysaccharide monooxygenase structure and chemistry. (2015) (62)
- NG-allyl- and NG-cyclopropyl-L-arginine: two novel inhibitors of macrophage nitric oxide synthase. (1992) (61)
- Formation of N delta-cyanoornithine from NG-hydroxy-L-arginine and hydrogen peroxide by neuronal nitric oxide synthase: implications for mechanism. (1997) (61)
- Nitric Oxide Binding to Prokaryotic Homologs of the Soluble Guanylate Cyclase β1 H-NOX Domain* (2006) (61)
- Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase (2013) (59)
- Cellular applications of a sensitive and selective fiber-optic nitric oxide biosensor based on a dye-labeled heme domain of soluble guanylate cyclase. (1999) (59)
- Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in the fungal pathogen Histoplasma capsulatum. (2008) (58)
- An Escherichia coli expression–based method for heme substitution (2007) (58)
- Horseradish peroxidase catalyzed hydroxylations: mechanistic studies. (1986) (57)
- Heme-assisted S-Nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide* (2012) (57)
- Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase (2014) (57)
- The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant. (2009) (56)
- Effects of transition metals on nitric oxide synthase catalysis. (1998) (55)
- The case of CO signaling: why the jury is still out. (2001) (54)
- Oxidation of NG-hydroxy-L-arginine by nitric oxide synthase: evidence for the involvement of the heme in catalysis. (1993) (52)
- Extracellular Aldonolactonase from Myceliophthora thermophila (2010) (52)
- Metal stoichiometry and functional studies of the diphtheria toxin repressor (2003) (52)
- Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain (2011) (52)
- Ru-porphyrin protein scaffolds for sensing O2. (2010) (51)
- Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. (2003) (50)
- Dissociation of Nitric Oxide from Soluble Guanylate Cyclase and Heme-Nitric Oxide/Oxygen Binding Domain Constructs* (2007) (48)
- Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy (2019) (47)
- Effects of Nitroglycerin on Soluble Guanylate Cyclase (2002) (47)
- Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase. (1995) (46)
- Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase. (1998) (46)
- Heme binding to the histidine-rich protein II from Plasmodium falciparum. (2005) (43)
- Carcinogen-binding proteins. High-affinity binding sites for benzo[a]pyrene in mouse liver distinct from the Ah receptor. (1984) (42)
- Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2. (2016) (41)
- Synthesis of nitric oxide by the NOS-like protein from deinococcus radiodurans: a direct role for tetrahydrofolate. (2009) (41)
- Physiological and Molecular Understanding of Bacterial Polysaccharide Monooxygenases (2017) (40)
- Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase. (2010) (40)
- NG-hydroxyguanidines from primary amines. (2006) (37)
- Sensitive and selective detection of nitric oxide using an H-NOX domain. (2006) (37)
- Stereospecific oxidation of aliphatic alcohols catalyzed by galactose oxidase. (1982) (37)
- Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. (1997) (37)
- SPECTRAL AND LIGAND-BINDING PROPERTIES OF AN UNUSUAL HEMOPROTEIN, THE FERRIC FORM OF SOLUBLE GUANYLATE CYCLASE (1996) (37)
- Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. (1997) (36)
- Porphyrin-substituted H-NOX proteins as high-relaxivity MRI contrast agents. (2013) (35)
- Allorecognition upon Fungal Cell-Cell Contact Determines Social Cooperation and Impacts the Acquisition of Multicellularity (2019) (34)
- Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. (2008) (34)
- Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase. (1997) (33)
- Determinants of ligand affinity and heme reactivity in H-NOX domains. (2010) (33)
- Structural insights into the molecular mechanism of H‐NOX activation (2010) (33)
- Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX. (2016) (33)
- Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans. (2010) (32)
- Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. (2010) (32)
- Butyl Isocyanide as a Probe of the Activation Mechanism of Soluble Guanylate Cyclase (2007) (32)
- Nucleotide regulation of soluble guanylate cyclase substrate specificity. (2009) (32)
- Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? (2001) (31)
- Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase. (2007) (31)
- Characterization of C415 mutants of neuronal nitric oxide synthase. (1996) (31)
- Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. (2012) (30)
- Resonance raman characterization of the heme domain of soluble guanylate cyclase. (1998) (30)
- DISTAL POCKET POLARITY IN THE UNUSUAL LIGAND BINDING SITE OF SOLUBLE GUANYLATE CYCLASE : IMPLICATIONS FOR THE CONTROL OF .NO BINDING (1996) (30)
- Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers (2009) (29)
- Use of a semisynthetic epitope to probe histidine kinase activity and regulation. (2010) (29)
- Stereochemical outcome of processing of fluorinated substrates by ATP citrate lyase and malate synthase. (1981) (29)
- Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat (2012) (28)
- Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila. (2007) (28)
- Fluorinated substrate analogues as stereochemical probes of enzymatic reaction mechanisms. (1978) (28)
- Cu2+ and Zn2+ Inhibit Nitric-oxide Synthase through an Interaction with the Reductase Domain* (2000) (28)
- Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. (2001) (27)
- Expression and characterization of the Neurospora crassa endoglucanase GH5-1. (2011) (27)
- Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine. (1979) (27)
- Glycosidic Bond Hydroxylation by Polysaccharide Monooxygenases (2019) (27)
- Starch-degrading polysaccharide monooxygenases (2016) (26)
- Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B (2015) (26)
- Direct meso-alkynylation of metalloporphyrins through gold catalysis for hemoprotein engineering. (2014) (26)
- The activation of neuronal NO synthase is mediated by G‐protein βγ subunit and the tyrosine phosphatase SHP‐2 (1999) (26)
- Trace elements and nitric oxide function. (2003) (25)
- Resonance Raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation. (2009) (25)
- Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. (2010) (24)
- A Random-Sequential Kinetic Mechanism for Polysaccharide Monooxygenases. (2018) (24)
- A new decoration for nitric oxide synthase - a Zn(Cys)4 site. (1999) (23)
- Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network (2013) (23)
- Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy. (2002) (22)
- The high-potential flavin and heme of nitric oxide synthase are not magnetically linked: implications for electron transfer. (1998) (22)
- Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase. (1982) (22)
- L-arginine analogs as alternate substrates for nitric oxide synthase. (2005) (21)
- N(G)-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. (2008) (21)
- Mechanism of inactivation of neuronal nitric oxide synthase by N(ω)-allyl-L-arginine (1997) (21)
- The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase. (2006) (20)
- N-nitrosamine formation by macrophages. (1987) (20)
- Trichothecene metabolism studies: isolation and structure determination of 15-acetyl-3.alpha.-(1'.beta.-D-glucopyranosiduronyl)scirpen-3,4.beta.,15-triol (1985) (20)
- &agr;1-A680T Variant in GUCY1A3 as a Candidate Conferring Protection From Pulmonary Hypertension Among Kyrgyz Highlanders (2014) (19)
- Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase. (1997) (19)
- Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases. (1999) (19)
- Redox couples of inducible nitric oxide synthase. (2005) (18)
- Spectroscopic and kinetic studies of Nor1, a cytochrome P450 nitric oxide reductase from the fungal pathogen Histoplasma capsulatum. (2008) (18)
- Substrate selectivity in starch polysaccharide monooxygenases (2019) (18)
- Further studies on murine macrophage synthesis of nitrite and nitrate. (1987) (17)
- Controlling conformational flexibility of an O₂-binding H-NOX domain. (2011) (17)
- Incorporation of Tyrosine and Glutamine Residues into the Soluble Guanylate Cyclase Heme Distal Pocket Alters NO and O2 Binding* (2010) (17)
- Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase. (1996) (17)
- Xenobiotic metabolism and mutation in a human lymphoblastoid cell line. (1985) (16)
- Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. (2005) (16)
- Amino acid substitution and modification resulting from Escherichia coli expression of recombinant Plasmodium falciparum histidine-rich protein II. (2005) (16)
- Nitric Oxide-Induced Conformational Changes Govern H-NOX and Histidine Kinase Interaction and Regulation in Shewanella oneidensis. (2017) (16)
- Carbon‐13 nuclear magnetic resonance studies of creatine, creatinine and some of their analogs (1980) (15)
- Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). (2012) (15)
- Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein. (1990) (15)
- Probing domain interactions in soluble guanylate cyclase. (2011) (15)
- Reconstitution of Pterin-free Inducible Nitric-oxide Synthase* (2001) (14)
- Trichothecene metabolism studies. 2. Structure of 3α-(1″gb-D-glucopyranosiduronyl)-8α-isovaleryloxy-scirpen-3,4β, 15-triol 15-acetate produced from T-2 toxin (1985) (14)
- Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex (2017) (14)
- Kinetic and immunochemical studies of a receptor-like protein that binds aromatic hydrocarbons. (1988) (13)
- Porphyrin π-stacking in a heme protein scaffold tunes gas ligand affinity. (2013) (13)
- Structural Insight into H‐NOX Gas Sensing and Cognate Signaling Protein Regulation (2018) (13)
- Structural Perspectives on the Mechanism of Soluble Guanylate Cyclase Activation (2021) (11)
- The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides (2015) (10)
- 4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase. (2009) (10)
- Design and characterization of an active site selective caspase-3 transnitrosating agent. (2006) (10)
- Superoxide-promoted oxidation reactions of aniline and N-methylaniline in dimethyl sulfoxide (1985) (10)
- Determinants of the heme-CO vibrational modes in the H-NOX family. (2011) (10)
- Carboxylesterase isoenzyme specific deacylation of diacetoxyscirpenol (anguidine). (1988) (10)
- Raising enzymes from the dead and the secrets they can tell. (2006) (9)
- Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes (2018) (9)
- Characterization of a Carbon Monoxide-Activated Soluble Guanylate Cyclase from Chlamydomonas reinhardtii. (2019) (9)
- Purification of a benzo[a]pyrene binding protein by affinity chromatography and photoaffinity labeling. (1986) (9)
- The activation of neuronal NO synthase is mediated by G-protein betagamma subunit and the tyrosine phosphatase SHP-2. (1999) (9)
- Mapping the H-NOX/HK Binding Interface in Vibrio cholerae by Hydrogen/Deuterium Exchange Mass Spectrometry. (2018) (9)
- Corrole-Substituted Fluorescent Heme Proteins. (2021) (8)
- An Escherichia coli expression-based approach for porphyrin substitution in heme proteins. (2013) (8)
- N(ω)-Propargyl-L-arginine and N(ω)-hydroxy-N(ω)-propargyl-L-arginine are inhibitors, but not activators, of neuronal and macrophage nitric oxide synthases (1997) (8)
- The 4S polycyclic aromatic hydrocarbon-binding protein: immunohistochemical localization in mice. (1990) (8)
- STRUCTURAL DYNAMICS IN THE GUANYLATE CYCLASE HEME POCKET AFTER CO PHOTOLYSIS (1999) (8)
- Utilizing RNA aptamers to probe a physiologically important heme-regulated cellular network. (2006) (7)
- Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms (2020) (7)
- Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (Water-ligated, ferric form) (2004) (6)
- Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. (2007) (6)
- Nitric oxide signaling controls collective contractions in a colonial choanoflagellate (2022) (6)
- TRICHOTHECENE METABOLISM STUDIES: ISOLATION AND STRUCTURE DETERMINATION OF 15-ACETYL-3α-(1′β-D-GLUCOPYRANOSIDURONYL)SCIRPEN-3,4β,15-TRIOL (1985) (6)
- Macrophage nitric oxide synthase: tetrahydrobiopterin decreases the NADPH stoichiometry. (1993) (6)
- Monoclonal antibody-directed determination of cytochrome P-450 types expressed in a human lymphoblastoid cell line. (1985) (5)
- Native Alanine Substitution in the Glycine Hinge Modulates Conformational Flexibility of Heme Nitric Oxide/Oxygen (H-NOX) Sensing Proteins. (2018) (5)
- Expression and characterization of the Neurospora crassa endoglucanase GH 5-1 (2010) (5)
- A Dual-H-NOX Signaling System in Saccharophagus degradans. (2018) (4)
- Development of an affinity chromatography resin for the purification of carcinogen binding proteins from mouse liver. (1985) (4)
- A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition (2022) (4)
- An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism (2020) (4)
- Glycosidic Bond Oxidation: The Structure, Function, and Mechanism of Polysaccharide Monooxygenases (2020) (4)
- Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going? (2021) (4)
- Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp . Strain TrichCH 4 B (2015) (4)
- Comparison of aniline hydroxylation by hemoglobin and microsomal cytochrome P450 using stable isotopes. (1994) (4)
- Effects of S-nitrosation of nitric oxide synthase (2007) (3)
- Serendipity in Discovery: From Nitric Oxide to Viagra 1 (2017) (3)
- Resonance Raman Spectra of an O2-Binding H-NOX Domain Reveal Heme Relaxation upon Mutation (2010) (3)
- Nitric oxide, nitrovasodilators, and L-arginine--an unusual relationship. (1991) (3)
- N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases. (1997) (2)
- Nitric oxide synthase functions as a catalytically self-sufficient cytochrome P450 (1992) (2)
- Conformational changes involved in sGC activation (2013) (1)
- Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) (2004) (1)
- L-Arginine Analogues as Alternate Substrates for Nitric Oxide Synthase. (2005) (1)
- The new regulation 2017/745: an opportunity for innovation (2020) (1)
- Nitric Oxide Synthase (NOS) (1993) (1)
- Catalytic domain of LPMO Lmo2467 from Listeria monocytogenes (2017) (1)
- Ratiometric Oxygen Sensing with H-NOX Protein Conjugates. (2022) (1)
- 69 Heme Proteins as Gas Sensors (2011) (1)
- and are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases (1997) (1)
- Author response: Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy (2019) (0)
- Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)CO ligation state, Q154A/Q155A/K156A mutant (2014) (0)
- Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase. (2023) (0)
- Compositions and methods for the administration of nitric oxide (2007) (0)
- Nucleotide regulation of soluble guanylate cyclase (1013.14) (2014) (0)
- Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)NO ligation state (2014) (0)
- Structural aspects of sGC activation (2019) (0)
- Mechanistic insights into nitric oxide activation of H‐NOX sensor proteins (1013.18) (2014) (0)
- Heme Sensor Proteins for Nitric Oxide: A Versatile Use of Captive Iron (2018) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 (2011) (0)
- An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism (2020) (0)
- Regulation of oxide signaling by formation of a distal receptor-ligand complex. (2017) (0)
- Active State of Manduca sexta soluble Guanylate Cyclase (2019) (0)
- MCB 100B Spring 2016: Biochemistry: Pathways, Mechanisms, and Regulation (2016) (0)
- Catalysis and regulation. Editorial overview. (2008) (0)
- Calmodulin bound to peptide from macrophage nitric oxide synthase (2010) (0)
- Crystal structure of Fe(II) unliganded H-NOX protein from K. algicida (2018) (0)
- Conformational changes involved in sGC activation (2013) (0)
- Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3*) (2017) (0)
- A novel pathway for bacterial nitric oxide signaling (614.3) (2014) (0)
- Correction to Inhibition of Soluble Guanylate Cyclase by ODQ (2012) (0)
- Molecular aspects of sGC regulation (2011) (0)
- From metals to radicals to light to loops: regulating complex reactions. (2010) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant (2011) (0)
- A molecular view of the regulation of sGC activity (2009) (0)
- A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in allorecognition in Neurospora crassa (2022) (0)
- Inactive State of Manduca sexta soluble guanylate cyclase (2019) (0)
- Starch-degrading polysaccharide monooxygenases (2016) (0)
- Nitric oxide inhibition selectively increases MMP-9 activation in vitro by aortic smooth muscle cells (2000) (0)
- Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon (2011) (0)
- Nitric Oxide: Biological Targets (2008) (0)
- Molecular steps in sGC activation (2007) (0)
- Inhibition of nitric oxide synthase with calmodulin binding peptides (2002) (0)
- Molecular steps in soluble guanylate cyclase activation (2005) (0)
- Crystal structure of Fe(II) CO-bound H-NOX protein from C. subterraneus (2016) (0)
- Control of bacterial chemotaxis by heme nitric oxide/oxygen proteins (614.2) (2014) (0)
- I5F Mutant Structure of T. Tengcongensis H-NOX (2011) (0)
- Characterization of heme protein sensors provides a basis for functional differences such as ligand recognition (2003) (0)
- High resolution crystal structure of the heme domain of GLB-6 from C. elegans (2010) (0)
- Crystal structure of Fe(II) unliganded H-NOX protein mutant A71G from K. algicida (2018) (0)
- Mechanistic studies of polysaccharide monooxygenases (584.8) (2014) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant (2011) (0)
- Tt I75F/L144F H-NOX (2010) (0)
- Structure and Function in Enzymology of Nitric Oxide Signaling (2003) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 1 atm of xenon (2011) (0)
- Characterization of a unique polysaccharide monooxygenase from the plant pathogen Magnaporthe oryzae. (2023) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon (2011) (0)
- Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus (2016) (0)
- Compositions and methods for delivery of oxygen (2007) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon (2011) (0)
- Corrole–protein interactions in H-NOX and HasA (2022) (0)
- Crystal structure of an H-NOX protein from T. tengcongensis (2011) (0)
- The activation of neuronal NO synthase is mediated by Gâ•’protein Î2Î3 subunit and the tyrosine phosphatase SHPâ•’2 (1999) (0)
- Editor's evaluation: Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism (2021) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant (2011) (0)
- Deciphering the Functional Role of Bacterial H-NOX Proteins By Charles William Hespen A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy (2016) (0)
- Soluble guanylate cyclase activation by nitric oxide (2018) (0)
- Ru-Porphyrin Protein Scaffolds for Sensing O[subscript 2] (2010) (0)
- Tricothecenes Mycotoxin Studies. (1983) (0)
- Binding of CI-1004 to human prostaglandin H2 synthase-2 and inhibition of cyclooxygenase activity (1998) (0)
- A higher degree of difficulty. (2007) (0)
- Enzymes, coenzymes and metabolic pathways July 14–18, 1996 Kimball Union Academy Meriden, NH, USA (1996) (0)
- Examining Oxygen Accessibility in H-NOX Proteins with a Phosphorescent Ruthenium Porphyrin (2010) (0)
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