Michael R. Duchen
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Biology
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(Suggest an Edit or Addition)Michael R. Duchen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS (2014) (1731)
- Mitochondria and calcium: from cell signalling to cell death (2000) (1130)
- Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004) (674)
- Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death (1999) (633)
- PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death (2009) (614)
- Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation (2007) (589)
- β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase (2004) (534)
- Cellular and molecular mechanisms of mitochondrial function (2012) (473)
- Unexpected low‐dose toxicity of the universal solvent DMSO (2014) (465)
- Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. (2003) (457)
- The role of mitochondrial function in the oocyte and embryo. (2007) (429)
- Roles of mitochondria in health and disease. (2004) (422)
- Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes (2010) (410)
- Separating NADH and NADPH fluorescence in live cells and tissues using FLIM (2014) (398)
- Mitochondria: the hub of cellular Ca2+ signaling. (2008) (396)
- The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. (2000) (393)
- Endothelial Mitochondria: Contributing to Vascular Function and Disease (2007) (340)
- Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. (1992) (335)
- Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity (2003) (335)
- Flirting in Little Space: The ER/Mitochondria Ca2+ Liaison (2004) (326)
- PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (311)
- Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes (1999) (308)
- On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. (1993) (304)
- Transient Mitochondrial Permeability Transition Pore Opening Mediates Preconditioning-Induced Protection (2004) (303)
- Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling (2013) (303)
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing (2018) (300)
- Mitochondria and Ca2+in cell physiology and pathophysiology (2000) (289)
- Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease (2013) (279)
- Preconditioning protects by inhibiting the mitochondrial permeability transition. (2004) (277)
- Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body. (1992) (270)
- Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore. (2002) (270)
- Transient Mitochondrial Depolarizations Reflect Focal Sarcoplasmic Reticular Calcium Release in Single Rat Cardiomyocytes (1998) (255)
- Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure. (2015) (250)
- Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1. (2008) (249)
- Investigating mitochondrial redox state using NADH and NADPH autofluorescence (2016) (248)
- The large-conductance Ca2+-activated K+ channel is essential for innate immunity (2004) (224)
- Imaging mitochondrial function in intact cells. (2003) (222)
- Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes (2005) (220)
- Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. (2006) (219)
- Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production (2004) (217)
- The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes. (1996) (216)
- Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. (2004) (215)
- Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. (1992) (212)
- Mitochondrial function and redox state in mammalian embryos. (2009) (209)
- Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. (2006) (209)
- Regulation of redox metabolism in the mouse oocyte and embryo (2006) (207)
- Glutamate‐induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones (1999) (202)
- The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α (2016) (190)
- Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering (2018) (187)
- Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. (2013) (179)
- Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. (2008) (178)
- Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health☆☆☆ (2014) (171)
- Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death (2007) (170)
- Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. (2005) (169)
- Mitochondria and Ca(2+)in cell physiology and pathophysiology. (2000) (168)
- Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage (2013) (168)
- Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells (2019) (167)
- Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system (1997) (164)
- Mitochondria, calcium-dependent neuronal death and neurodegenerative disease (2012) (161)
- Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) (2012) (159)
- Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. (1993) (156)
- G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization (2012) (156)
- Roles of mitochondria in human disease. (2010) (155)
- Mitochondria and calcium in health and disease. (2008) (148)
- Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. (2011) (148)
- Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture (2001) (146)
- Mitochondria as Targets for Nitric Oxide-Induced Protection During Simulated Ischemia and Reoxygenation in Isolated Neonatal Cardiomyocytes (2001) (145)
- Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes (2017) (145)
- PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease (2016) (143)
- The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides (2005) (143)
- Responses of type I cells dissociated from the rabbit carotid body to hypoxia. (1990) (142)
- IF(1): setting the pace of the F(1)F(o)-ATP synthase. (2009) (136)
- Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. (1990) (135)
- Biophysical studies of the cellular elements of the rabbit carotid body (1988) (133)
- The regulation of neuronal mitochondrial metabolism by calcium (2015) (132)
- Interplay between mitochondria and cellular calcium signalling (2004) (130)
- Hypoxia‐induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration (1997) (129)
- IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. (2006) (128)
- NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming (2016) (126)
- Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. (2008) (125)
- Mitochondria, Ca2+ and neurodegenerative disease. (2002) (125)
- Multiphoton imaging reveals differences in mitochondrial function between nephron segments. (2009) (123)
- Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones. (1990) (122)
- Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane (2001) (121)
- CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia (2008) (120)
- Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets. (2019) (120)
- Lack of Oxygen Deactivates Mitochondrial Complex I (2009) (117)
- Toxicity of Amyloid β Peptide: Tales of Calcium, Mitochondria, and Oxidative Stress (2004) (117)
- Calcium signals and mitochondria at fertilisation. (2006) (117)
- The ‘mitoflash’ probe cpYFP does not respond to superoxide (2014) (115)
- Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress (2010) (115)
- Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass (2002) (112)
- Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons (1999) (112)
- Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations (2010) (110)
- Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress. (2004) (109)
- PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s (2014) (108)
- Expression of mutant SOD1G93A in astrocytes induces functional deficits in motoneuron mitochondria (2008) (103)
- The role of mitochondria in sepsis-induced cardiomyopathy. (2019) (100)
- Mitochondrial dynamics and quality control in Huntington's disease (2016) (98)
- Calcium signaling as a mediator of cell energy demand and a trigger to cell death (2015) (97)
- Measurements of intracellular Ca2+ in dissociated type I cells of the rabbit carotid body. (1989) (96)
- Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases (2017) (94)
- SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca2+ buffering (2011) (94)
- Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance. (2006) (92)
- Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders. (2017) (90)
- Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells. (2003) (90)
- Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons (1998) (88)
- Calcium microdomains and oxidative stress. (2006) (88)
- Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability (2017) (88)
- Vascular Endothelial Growth Factor (VEGF)-D and VEGF-A Differentially Regulate KDR-mediated Signaling and Biological Function in Vascular Endothelial Cells* (2004) (85)
- Membrane cholesterol content plays a key role in the neurotoxicity of β‐amyloid: implications for Alzheimer’s disease (2011) (85)
- FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation. (2006) (82)
- Mitochondrial 'flashes': a radical concept repHined. (2012) (81)
- Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis (2016) (81)
- Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. (2010) (79)
- An intracellular study of the interactions of N-methyl-dl-aspartate with ketamine in the mouse hippocampal slice (1985) (78)
- Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. (2002) (75)
- Impulse Conduction Increases Mitochondrial Transport in Adult Mammalian Peripheral Nerves In Vivo (2013) (74)
- Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration (2014) (74)
- Electrophysiological responses of dissociated type I cells of the rabbit carotid body to cyanide. (1989) (73)
- Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease (2012) (72)
- HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. (2015) (72)
- Differential expression of membrane currents in dissociated mouse primary sensory neurons (1990) (72)
- Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. (2012) (70)
- IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling (2013) (70)
- Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases (2013) (69)
- Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism (2005) (69)
- Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission (2015) (68)
- IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy. (2009) (67)
- Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity (2015) (67)
- Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts (2016) (66)
- Mitochondrial ND5 Gene Variation Associated with Encephalomyopathy and Mitochondrial ATP Consumption* (2007) (62)
- Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease (2012) (62)
- Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease (2017) (61)
- Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis* (2015) (60)
- Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells (2017) (59)
- PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1 (2014) (58)
- Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null‐mutant mice (2002) (57)
- Regulation of Mitochondrial Morphogenesis by Annexin A6 (2013) (54)
- AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue (2019) (54)
- Mitochondria mediated cell death in diabetes (2009) (53)
- Mechanisms of intracellular calcium regulation in adult astrocytes (1996) (53)
- Activated barrier crossing dynamics in the non-radiative decay of NADH and NADPH (2013) (52)
- Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis (2009) (52)
- Targeting the proteostasis network in Huntington’s disease (2019) (51)
- A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic β-cells (1995) (49)
- RyR1 Deficiency in Congenital Myopathies Disrupts Excitation–Contraction Coupling (2013) (46)
- Synaptic physiology of spinal motoneurones of normal and spastic mice: an in vitro study. (1986) (45)
- Assessing mitochondrial potential, calcium, and redox state in isolated mammalian cells using confocal microscopy. (2007) (44)
- Cellular basis of transduction in carotid chemoreceptors. (1990) (43)
- Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics☆ (2017) (41)
- Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors (2018) (41)
- Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury (2018) (40)
- Energy metabolism of adult astrocytes in vitro (1996) (39)
- Multiphoton imaging of the functioning kidney. (2011) (39)
- Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets? (2014) (37)
- Excitation of mouse motoneurones by GABA-mediated primary afferent depolarization (1986) (37)
- Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore (2015) (37)
- Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (35)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Effects of beauvericin on the metabolic state and ionic homeostasis of ventricular myocytes of the guinea pig. (2005) (33)
- Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity (2020) (32)
- The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1G93A Mouse Model for Motor Neuron Disease* (2010) (28)
- The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1 (2010) (28)
- Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells. (2009) (28)
- The compound BTB06584 is an IF1‐dependent selective inhibitor of the mitochondrial F1Fo‐ATPase (2014) (28)
- Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis (2015) (27)
- Imaging mitochondrial calcium signalling with fluorescent probes and single or two photon confocal microscopy. (2012) (26)
- Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. (2015) (25)
- Renal function and mitochondrial cytopathy (MC): more questions than answers? (2008) (24)
- Impaired Cellular Bioenergetics Causes Mitochondrial Calcium Handling Defects in MT-ND5 Mutant Cybrids (2016) (24)
- The large-conductance Ca2+-activated K+ channel is essential for innate immunity (2010) (24)
- Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload (2019) (23)
- MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology (2020) (21)
- An intracellular study of dentate, CA1 and CA3 neurones in the mouse hippocampal slice. (1985) (21)
- Actions and interactions of GABA and benzodiazepines in the mouse hippocampal slice. (1985) (20)
- Polarized Two-Photon Absorption and Heterogeneous Fluorescence Dynamics in NAD(P)H (2019) (20)
- ‘What nourishes me, destroys me’: towards a new mitochondrial biology (2001) (20)
- Cellular glutathione content in the organ of Corti and its role during ototoxicity (2015) (19)
- Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand (2017) (18)
- Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown (2021) (18)
- Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (18)
- Mitochondrial IF1 preserves cristae structure to limit apoptotic cell death signaling (2013) (17)
- A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification (2019) (17)
- Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria (2016) (17)
- Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic. (2018) (17)
- Simultaneous Measurement of Mitochondrial Calcium and Mitochondrial Membrane Potential in Live Cells by Fluorescent Microscopy. (2017) (16)
- Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide (2012) (14)
- Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium. (2011) (14)
- Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells (2015) (14)
- Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients (2018) (13)
- In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue (2015) (13)
- A genetic modifier suggests that endurance exercise exacerbates Huntington's disease (2018) (13)
- Monitoring exocytosis from single mast cells by fast voltammetry (1991) (13)
- Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation (2018) (12)
- Mitochondrial Dysfunction in Neurodegenerative Disorders (2012) (12)
- Modulation of the glutathione redox state in adult astrocytes. (1996) (11)
- Prostaglandin F2alpha potentiates the calcium dependent activation of mitochondrial metabolism in luteal cells. (2005) (11)
- Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease. (2016) (11)
- The anion selectivity of GABA-mediated post-synaptic potentials in mouse hippocampal cells. (1985) (10)
- Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening (2019) (10)
- Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation (2020) (10)
- Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells (2019) (10)
- Summary Sperm-triggered [ Ca 2 + ] oscillations and Ca 2 + homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production (2004) (10)
- Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency (2020) (10)
- Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator (2017) (9)
- The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases (2022) (9)
- Primary afferent terminal excitability in the normal and spastic mutant mouse spinal cord. (1987) (9)
- Chair's Introduction (2006) (9)
- Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy (2016) (9)
- Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training (2020) (8)
- Assessment of Cellular Redox State Using NAD(P)H Fluorescence Intensity and Lifetime. (2017) (8)
- Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis. (2021) (7)
- Functional Imaging of Mitochondria Within Cells (2001) (7)
- Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging. (2019) (7)
- Section III : Mitochondria ,-Cell Function , and Type 2 Diabetes Roles of Mitochondria in Health and Disease (2003) (6)
- Albumin Uptake in OK Cells Exposed to Rotenone: A Model for Studying the Effects of Mitochondrial Dysfunction on Endocytosis in the Proximal Tubule? (2010) (6)
- Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss (2019) (6)
- Direct and Cross-Protective Effects of Heat Adaptation in Cultured Cells (2003) (6)
- Electrophysiological and metabolic effects of a convulsant barbiturate on dissociated mouse primary sensory neurons. (1995) (6)
- Adaptation to Heat of Cardiomyoblasts in Culture Protects Them against Heat Shock: Role of Nitric Oxide and Heat Shock Proteins (2003) (6)
- Rewiring cell signalling pathways in pathogenic mtDNA mutations (2021) (6)
- Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small‐volume resuscitation with terlipressin in a rat model of haemorrhagic shock (2017) (5)
- Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation. (2021) (4)
- Characterizing Metabolic States Using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H (2017) (4)
- Voltammetric measurement of catecholamine release from isolated rat chromaffin cells (1990) (4)
- Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy. (2018) (4)
- Mitochondrial Bioenergetics Assessed by Functional Fluorescence Dyes (2014) (4)
- Changes in mimtochondrial membrane potential and [Ca2+]i with hypoxia in type I cells isolated from the rabbit carotid body (1990) (4)
- The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy (2021) (3)
- The compound BTB06584 is an IF 1 -dependent selective inhibitor of the mitochondrial F 1 Fo-ATPase (2014) (3)
- Inhibition in the spinal cord of the normal and spastic mutant mouse in vitro (1985) (3)
- IF1 limits the apoptotic-signalling cascade by preventing remodeling of mitochondria (2013) (3)
- VOLTAMMETRIC MONITORING OF 5-HT SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS (1994) (2)
- The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities (2018) (2)
- Analysis of Organization and Activity of Mitochondrial Respiratory Chain Complexes in Primary Fibroblasts Using Blue Native PAGE. (2022) (2)
- Separation of NADPH and NADH Fluorescence Emission in Live Cells using Flim (2012) (2)
- Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines (2021) (2)
- Mitochondria : Form and function Thursday 14 – Friday 15 September (2017) (2)
- Heterogeneity and restricted state selection in FRET with fluorescent proteins (2016) (2)
- 0036. Confocal imaging of impaired mitochondrial function in the cerebral cortex of rats during haemorrhagic shock in vivo (2014) (2)
- Loss of mitochondrial function and impaired mitochondrial trafficking at the onset of neurological deficits in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo confocal imaging (2013) (2)
- USE OF MICROFLUORIMETRY TO MONITOR MITOCHONDRIAL-MEMBRANE POTENTIAL IN SINGLE DISSOCIATED MAMMALIAN-CELLS (1990) (2)
- AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue (2019) (2)
- Comprar Mitochondrial Dysfunction In Neurodegenerative Disorders 2nd Ed. | Amy K. Reeve | 9783319286358 | Springer (2016) (1)
- Antiapoptotic Effect of Heat Adaptation in Cultured Cells (2003) (1)
- Focal cerebal ischemia-reperfusion induces the Nrf2 downstream target PPARγ in mouse cerebrovascular endothelium (2016) (1)
- Maladaptive nutrient signalling sustains the m.3243A>G mtDNA mutation (2020) (1)
- How do arterial chemoreceptors works? Studies of cells from the carotid body of the rabbit (1991) (1)
- Using multiphoton microscopy to examine the response of the heart to ischaemia and reperfusion injury (2008) (1)
- Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel. (2019) (1)
- P19 Low levels of the A3243G MTDNA mutation in human induced pluripotent stem cell-cardiomyocytes do not cause functional or metabolic disturbances but increase with further passaging (2018) (1)
- NRF 2 Orchestrates the Me tabolic Shift during Induced Pluripotent Stem Cell Reprogramming Graphical (2016) (1)
- Mitochondrial respiratory states and rates: building blocks of mitochondrial physiology (2018) (1)
- Final general discussion (2006) (1)
- The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH (2014) (1)
- Symposium Overview (2000) (1)
- Intracellular calcium and mitochondrial function in cell physiology and pathophysiology (1994) (1)
- Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload (2019) (1)
- Imaging mitochondrial function in single cells (2001) (1)
- General discussion II (2006) (1)
- The anti-ischemic effect of low-dose FCCP involves mitochondrial oxidation without detectable depolarisation (2002) (1)
- Paracoccus complex I as a model for the bovine enzyme: Developing methods to study proton translocation (2012) (0)
- 1319 Neurotoxic effect of glutamate on cultured hippocampal neurons studied by video microscopy (1996) (0)
- Preconditioning via Mitochondrial KATP Channel Activation Protects Cardiomyocytes from Oxidative Stress by Inhibiting Mitochondrial Permeability Transition Pore Opening (2003) (0)
- Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes (2023) (0)
- The Ca 2 +-dependent ATP-Mg / Pi carriers as novel regulators of the mitochondrial permeability transition pore (2010) (0)
- THE CHEMICAL AGENT BTB06584 TARGETS THE REVERSION OF THE MITOCHONDRIAL F1FO-ATP SYNTHASE MIMICKING IF1 (2014) (0)
- Sulforaphane pre‐treatment reduces blood‐brain barrier disruption in experimental stroke by inducing heme oxygenase‐1 expression in the glio‐vascular complex of the peri‐infarct region (2013) (0)
- Mitochondrial dysfunction and Purkinje cell loss in the human spastic ataxia ARSACS. (2011) (0)
- 0033. Hypothermia protects brain mitochondrial function from hypoxia in sepsis (2014) (0)
- bioenergetics (but not UCP3) in a rodent model of sepsis Skeletal muscle dysfunction is associated with derangements in mitochondrial (2015) (0)
- Does the mitochondrial permeability transition have a role in preconditioning? Response (2004) (0)
- SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, [CA-2+]I AND KATP CHANNELS IN MOUSE PANCREATIC BETA-CELLS INVITRO (1993) (0)
- Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload (2020) (0)
- Identifying neural drive to arm muscles using Transcranial Magnetic Stimulation and Transmastoid Electrical Stimulation (2017) (0)
- A39 Triad of neuronal vulnerability in huntington’s disease: huntingtin proteostasis, inclusion body formation and mitochondrial function (2018) (0)
- Heart/Cardiac Muscle (2005) (0)
- GBA1 deficiency sensitises neurons to glutamate toxicity and causes calcium dyshomeostasis (2017) (0)
- CHAPTER 135 – Mitochondria and Calcium Signaling, Point and Counterpoint (2003) (0)
- APP(SWE)/PS1A246E astroglioma cells show mitochondrial dysfunction, calcium dyshomeostasis and higher vulnerability to ischemia (2017) (0)
- Neomycin Mediates Changes in Cytosolic and Mitochondrial Calcium in Rat Hair Cells in Vitro (2009) (0)
- Polyphosphate in mitochondrial function. (2007) (0)
- Actions of Ca(2+) ionophores on mitochondria in intact cells. (2001) (0)
- Monitoring Mitochondrial Membrane Potential in Live Cells Using Time-Lapse Fluorescence Imaging. (2022) (0)
- Comprar Mitochondrial Dysfunction in Neurodegenerative Disorders | Reeve, A.K. | 9780857297006 | Springer (2011) (0)
- Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide (2012) (0)
- Mitochondria and Control Defects in a Mouse Model of Gaucher Disease-Links to Parkinson's Disease (2020) (0)
- Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery (2012) (0)
- Dimethylfumarate as a treatment for multiple sclerosis: a role for mitochondria? (2017) (0)
- cardioprotection in the human heart Mitochondrial permeability transition pore as a target for (2016) (0)
- Selective mitochondrial antioxidant MitoTempo reduces renal dysfunction and systemic interleukin-1beta without impairing macrophage oxidative burst in experimental sepsis (2021) (0)
- Prostacyclin synthase activity regulates the adipose depot specific IL-6 secretion (2007) (0)
- MITOCHONDRIAL TRANSITION PORE AND PRECONDITIONING 1 PRECONDITIONING PROTECTS BY INHIBITING THE MITOCHONDRIAL PERMEABILITY TRANSITION (2004) (0)
- Low levels of the A3243G mitochondrial DNA mutation in human induced pluripotent stem cell-cardiomyocytes do not cause functional or metabolic disturbances but increase with further passaging (2017) (0)
- A homoplasmic ND5 mutation associated with MELAS: mitochondria as ATP consumers? (2004) (0)
- P439Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury (2014) (0)
- Multiple sclerosis from an energy perspective. (2016) (0)
- In mtDNA diseases, the reversion of the F1Fo-ATPsynthase is associated to defects in mitochondrial quality control: Evidence for a novel pathogenic mechanism and therapeutic target (2011) (0)
- Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide (2012) (0)
- Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases (2017) (0)
- Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB (2022) (0)
- Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells (2019) (0)
- Mitochondrial Communication in Physiology, Disease and Aging (2019) (0)
- Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability (2017) (0)
- Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide (2012) (0)
- S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1 (2008) (0)
- 15P.21 The Ca-dependent ATP-Mg/Pi carriers as novel regulators of the mitochondrial permeability transition pore (2010) (0)
- Best Practice & Research Clinical Endocrinology & Metabolism (2012) (0)
- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia (2009) (0)
- Mitochondria Regulate Agonist Induced Cytoplasmic Calcium Signals in Cochlear Support Cells (2006) (0)
- Biophysical Studies of Cells from the Carotid Body of the Rabbit (1990) (0)
- Crystal structure of cyclophilin D in complex with CsA analogue, JW47. (2015) (0)
- 0889. Mitochondrial dysfunction contributes to sepsis-induces acute kidney injury (2014) (0)
- 320 Preconditioning protects via dual modulation of the mitochondrial permeability transition pore (2003) (0)
- Heme Oxygenase 1 Induction In The Peri-Infarct Region After Cerebral Ischemia-Reperfusion Injury In Rats Is Associated With Reduced Blood-Brain Barrier Breakdown (2012) (0)
- Spatial and temporal expression of Nrf2-inducible antioxidant defences in the gliovascular complex after stroke (2013) (0)
- Mitochondrial Dynamics and Oxidative Stress Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics ( but not UCP 3 ) in a rodent model of sepsis (2015) (0)
- Investigating Mitochondrial Ca2+ Dynamics in Isolated Mitochondria and Intact Cells: Application of Fluorescent Dyes and Genetic Reporters. (2022) (0)
- Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation (2018) (0)
- Mitochondria, calcium-dependent neuronal death and neurodegenerative disease (2012) (0)
- Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. VOLUME 279 (2004) PAGES 36148-36157 (2006) (0)
- The mitochondrial ATP synthase as an ATP consumer-a surprising therapeutic target. (2023) (0)
- Distinct NAD(P)H binding configurations revealed by fluorescence lifetime, anisotropy and polarised two-photon absorption. (2023) (0)
- Muscle degeneration due to skeletal ion channel dysfunction (2012) (0)
- on Mitochondrial Redox Signaling in Health and Disease (2016) (0)
- Mitochondria and calcium signaling in cell life and cell death (2018) (0)
- Pathological consequences of mutations of MICU1 for mitochondrial calcium signaling and bioenergetics (2016) (0)
- Does the mitochondrial permeability transition pore have a role in preconditioning?-letter to editor (2004) (0)
- Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis (2009) (0)
- Mitochondria as organizers of the cellular Ca 2+ Signaling Network (2010) (0)
- General discussion III (2006) (0)
- The Ca2+-dependent ATP-Mg/Pi carriers as novel regulators of the mitochondrial permeability transition pore (2010) (0)
- From gene to phenotype: Modelling the glucose stimulated insulin secretion system (2010) (0)
- Mitochondrial fragmentation and loss of function at the onset of neurological deficit in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo imaging (2012) (0)
- A Plate Reader-Based Measurement of the Cellular ROS Production Using Dihydroethidium and MitoSOX. (2022) (0)
- Rosiglitazone protects differentiated SH-SY5Y cells against damage induced by rotenone through mitochondrial biogenesis and by anti-oxidative mechanisms (2012) (0)
- PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington’s disease (2023) (0)
- S12.37 The inhibitory protein 1f1 regulates cellular sensitivity to staurosporine-induced cell death (2008) (0)
- PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s (2014) (0)
- Assessing the Redox Status of Mitochondria Through the NADH/FAD2+ Ratio in Intact Cells. (2022) (0)
- Altered cardiomyocyte dynamics in annexin VI knockout mice (1999) (0)
- Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease (2012) (0)
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What Schools Are Affiliated With Michael R. Duchen?
Michael R. Duchen is affiliated with the following schools:
