Michael Rosbash | Academic Influence

Michael Rosbash's AcademicInfluence.com Rankings

Michael Rosbash

Biology

#199

World Rank

#365

Historical Rank

#115

USA Rank

Genetics

#63

World Rank

#95

Historical Rank

#42

USA Rank

biology Degrees

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Biology

Michael Rosbash's Degrees

Bachelors Physics California Institute of Technology

Why Is Michael Rosbash Influential?

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According to Wikipedia, Michael Morris Rosbash is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm".

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Michael Rosbash's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels (1990) (1068)
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila (1998) (926)
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity (1998) (834)
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless (1998) (723)
Coupled oscillators control morning and evening locomotor behaviour of Drosophila (2004) (659)
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless (1998) (639)
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila (2001) (626)
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. (2000) (572)
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila (1999) (568)
PAS is a dimerization domain common to Drosophila Period and several transcription factors (1993) (541)
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. (2000) (531)
Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene (1984) (505)
A light-entrainment mechanism for the Drosophila circadian clock (1996) (494)
Three abundance classes in HeLa cell messenger RNA (1974) (492)
Temporal phosphorylation of the Drosophila period protein. (1994) (449)
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export (1997) (446)
Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila (1990) (421)
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm (1989) (412)
Drosophila CRY Is a Deep Brain Circadian Photoreceptor (2000) (395)
Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system (1988) (382)
Quality control of mRNA 3′-end processing is linked to the nuclear exosome (2001) (375)
Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms (1984) (371)
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit (2008) (371)
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals (1997) (368)
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing (1989) (361)
The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC (1997) (349)
Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms (1992) (343)
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP (2000) (342)
Members of a family of drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs (1994) (326)
Stopping time: the genetics of fly and mouse circadian clocks. (2001) (325)
P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic drosophila melanogaster (1984) (324)
A U1 snRNA:pre‐mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site. (1988) (320)
A role for casein kinase 2α in the Drosophila circadian clock (2002) (301)
A resetting signal between Drosophila pacemakers synchronizes morning and evening activity (2005) (291)
Roles of the Two Drosophila CRYPTOCHROME Structural Domains in Circadian Photoreception (2004) (285)
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation (2012) (284)
Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock (1995) (283)
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the drosophila nervous system (1994) (276)
Post‐transcriptional regulation contributes to Drosophila clock gene mRNA cycling (1997) (275)
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. (1993) (273)
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator (2005) (269)
Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation (2002) (268)
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain (2008) (263)
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. (1998) (253)
Polynucleotide sequences in eukaryotic DNA and RNA that form ribonuclease-resistant complexes with polyuridylic acid. (1974) (251)
Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. (2011) (250)
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior (2000) (249)
Drosophila Free-Running Rhythms Require Intercellular Communication (2003) (248)
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast (1995) (244)
Sequential Nuclear Accumulation of the Clock Proteins Period and Timeless in the Pacemaker Neurons of Drosophila melanogaster (2002) (239)
Nuclear RNA export. (1998) (238)
Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. (1994) (237)
The Drosophila Circadian Network Is a Seasonal Timer (2007) (236)
Polyadenylic acid-containing RNA in Xenopus laevis oocytes. (1974) (235)
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene (1987) (231)
Number and distribution of polyadenylated RNA sequences in yeast (1977) (221)
Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. (1995) (220)
Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin. (1970) (217)
Isolation of yeast histone genes H2A and H2B (1979) (215)
Circadian oscillations in period gene mRNA levels are transcriptionally regulated. (1992) (215)
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain (2013) (212)
Circadian Neuron Feedback Controls the Drosophila Sleep-Activity Profile (2016) (211)
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes (1986) (210)
Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. (2005) (207)
A Drosophila Minute gene encodes a ribosomal protein (1985) (206)
A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. (2001) (201)
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. (2007) (200)
The Implications of Multiple Circadian Clock Origins (2009) (200)
The NES–Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae (1999) (199)
A role for casein kinase 2alpha in the Drosophila circadian clock. (2002) (198)
Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. (1991) (197)
The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. (1994) (196)
Medicine in the Fourth Dimension. (2019) (188)
Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes (2004) (179)
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila (2008) (176)
A role for microRNAs in the Drosophila circadian clock. (2009) (173)
CLOCK:BMAL1 is a pioneer-like transcription factor (2014) (173)
Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing (1983) (170)
Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. (1986) (168)
The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. (2004) (166)
Drosophila cryptochromes: A unique circadian-rhythm photoreceptor (2000) (166)
mRNA splicing efficiency in yeast and the contribution of nonconserved sequences (1985) (166)
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing (2002) (163)
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. (1998) (162)
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila (2010) (161)
The molecular biology of circadian rhythms (1989) (159)
The DECD box putative ATPase Sub2p is an early mRNA export factor (2001) (159)
Spatial and temporal expression of the period gene in Drosophila melanogaster. (1988) (157)
The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. (1996) (156)
Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. (1987) (154)
Who's on first? The U1 snRNP-5' splice site interaction and splicing. (1991) (153)
The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast (1981) (148)
Phase shifting of the circadian clock by induction of the Drosophila period protein. (1994) (147)
The disconnected Visual System Mutations in Drosophila melanogaster Drastically Disrupt Circadian Rhythms (1989) (147)
Guidelines for Genome-Scale Analysis of Biological Rhythms (2017) (146)
PER protein interactions and temperature compensation of a circadian clock in Drosophila (1995) (146)
Dissecting differential gene expression within the circadian neuronal circuit of Drosophila (2010) (144)
Evidence that the TIM Light Response Is Relevant to Light-Induced Phase Shifts in Drosophila melanogaster (1998) (144)
Early commitment of yeast pre-mRNA to the spliceosome pathway (1988) (141)
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins (2016) (139)
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation (2002) (136)
The period gene encodes a predominantly nuclear protein in adult Drosophila (1992) (135)
Effect of constant light and circadian entrainment of perS flies: evidence for light‐mediated delay of the negative feedback loop in Drosophila. (1996) (134)
Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila (1987) (134)
Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. (1999) (134)
takeout, a Novel DrosophilaGene under Circadian Clock Transcriptional Regulation (2000) (134)
Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure. (1992) (132)
A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. (2006) (128)
Interspecific comparison of the period gene of Drosophila reveals large blocks of non‐conserved coding DNA. (1988) (128)
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. (2010) (128)
Early formation of mRNP: license for export or quality control? (2003) (127)
Temporal and Spatial Expression Patterns of Transgenes Containing Increasing Amounts of the Drosophila Clock Geneperiod and a lacZ Reporter: Mapping Elements of the PER Protein Involved in Circadian Cycling (1997) (125)
The period clock locus of D. melanogaster codes for a proteoglycan (1986) (125)
Membrane-associated protein synthesis of mammalian cells. I. The two classes of membrane-associated ribosomes. (1971) (121)
Drosophila Clock Can Generate Ectopic Circadian Clocks (2003) (119)
Drosophila homologs of two mammalian intracellular Ca(2+)-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes. (1992) (116)
The Coevolution of Blue-Light Photoreception and Circadian Rhythms (2003) (116)
Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. (2012) (115)
Short Neuropeptide F Is a Sleep-Promoting Inhibitory Modulator (2013) (113)
Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast. (1983) (113)
Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. (2009) (112)
A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript. (2004) (110)
In vivo characterization of yeast mRNA processing intermediates (1984) (109)
Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. (2011) (108)
The period gene of Drosophila carries species‐specific behavioral instructions. (1988) (107)
Accumulation of individual pA+ RNAs during oogenesis of Xenopus laevis (1980) (105)
Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing (1985) (105)
The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region. (1997) (104)
Behavior of period-altered circadian rhythm mutants ofDrosophila in light: Dark cycles (Diptera: Drosophilidae) (1992) (102)
An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing. (1993) (102)
T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export. (2002) (102)
A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus (1996) (102)
A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing (1985) (99)
The timSL Mutant of the Drosophila Rhythm Gene timeless Manifests Allele-Specific Interactions with period Gene Mutants (1996) (99)
Two Novel doubletime Mutants Alter Circadian Properties and Eliminate the Delay between RNA and Protein inDrosophila (2000) (98)
Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization. (1995) (96)
A Drosophila circadian clock. (1996) (96)
Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. (1985) (96)
A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila (2018) (96)
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA‐pre‐mRNA complex and is recognized in the absence of U2 snRNA. (1991) (95)
Effect of RP51 gene dosage alterations on ribosome synthesis in Saccharomyces cerevisiae (1985) (95)
The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding (1990) (95)
Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. (2012) (94)
Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. (1992) (93)
PDF neuron firing phase-shifts key circadian activity neurons in Drosophila (2014) (92)
Wild-Type Circadian Rhythmicity Is Dependent on Closely Spaced E Boxes in the Drosophila timelessPromoter (2001) (91)
When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders (2011) (91)
Specific small nuclear RNAs are associated with yeast spliceosomes (1986) (89)
In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. (2006) (89)
Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginal Drosophila melanogaster. (1990) (87)
RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides (2017) (86)
Isolation and mapping of a cloned ribosomal protein gene of Drosophila melanogaster (1980) (85)
Ribosome components are associated with sites of transcription. (2002) (82)
Nascent-Seq analysis of Drosophila cycling gene expression (2013) (82)
Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. (2003) (82)
Isolation of cloned DNA sequences containing ribosomal protein genes from saccharomyces cerevisiae (1979) (81)
Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast (1993) (81)
S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA (1987) (81)
A high affinity binding site for the HIV-1 nucleocapsid protein. (1997) (80)
Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. (2012) (79)
Molecular coevolution within a Drosophila clock gene. (1998) (78)
RNA travel: Tracks from DNA to cytoplasm (1993) (78)
A functional interaction between Rev and yeast pre‐mRNA is related to splicing complex formation. (1994) (78)
Circadian Transcription Contributes to Core Period Determination in Drosophila (2008) (78)
A biochemical function for the Sm complex. (2001) (77)
RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point. (1986) (77)
Circadian Cycling of a PERIOD-β-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation (1997) (75)
Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. (2006) (75)
The Transcription Factor Mef2 Links the Drosophila Core Clock to Fas2, Neuronal Morphology, and Circadian Behavior (2013) (73)
Short artificial hairpins sequester splicing signals and inhibit yeast pre-mRNA splicing (1993) (73)
A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude (2003) (73)
Behavior of individual maternal pA+ RNAs during embryogenesis of Xenopus laevis. (1982) (73)
A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms. (1989) (72)
3′‐end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation (2006) (71)
Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing (1990) (70)
A Small Conserved Domain of Drosophila PERIOD Is Important for Circadian Phosphorylation, Nuclear Localization, and Transcriptional Repressor Activity (2007) (67)
Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement and contribute to the ribosomes (1984) (67)
PER-TIM Interactions with the Photoreceptor Cryptochrome Mediate Circadian Temperature Responses in Drosophila (2007) (67)
The syntheiss of high yields of full-length reverse transcripts of globin mRNA. (1977) (66)
Imaging analysis of clock neurons: light buffers the wake-promoting effect of dopamine (2011) (66)
Mutations and molecules influencing biological rhythms. (1988) (66)
Reiteration frequency of duck haemoglobin genes. (1973) (65)
Genome-Wide Analysis of Light- and Temperature-Entrained Circadian Transcripts in Caenorhabditis elegans (2010) (65)
PDF and cAMP enhance PER stability in Drosophila clock neurons (2014) (64)
The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function. (1992) (64)
Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. (1990) (64)
Genome-wide identification of neuronal activity-regulated genes in Drosophila (2016) (63)
Efficient trans-splicing of a yeast mitochondrial RNA group II intron implicates a strong 5' exon-intron interaction. (1986) (62)
Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking (2007) (62)
TIMELESS‐dependent positive and negative autoregulation in the Drosophila circadian clock (1999) (62)
A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock (1997) (61)
RNA structural patterns and splicing: molecular basis for an RNA-based enhancer. (1995) (61)
Requirements for U2 snRNP addition to yeast pre-mRNA. (1992) (59)
The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. (2012) (59)
The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression (1991) (58)
Molecular control of circadian rhythms. (1995) (58)
Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. (2007) (58)
Light-Mediated TIM Degradation within Drosophila Pacemaker Neurons (s-LNvs) Is Neither Necessary nor Sufficient for Delay Zone Phase Shifts (2010) (57)
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. (1982) (57)
The KH domain of the branchpoint sequence binding protein determines specificity for the pre-mRNA branchpoint sequence. (1998) (57)
Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly. (1996) (56)
An inducible promoter fused to the period gene in Drosophila conditionally rescues adult per-mutant arrhythmicity (1988) (54)
A post-transcriptional mechanism contributes to circadian cycling of a per-beta-galactosidase fusion protein. (1991) (54)
PDF Cycling in the Dorsal Protocerebrum of the Drosophila Brain Is Not Necessary for Circadian Clock Function (2006) (53)
Temporal calcium profiling of specific circadian neurons in freely moving flies (2017) (52)
Analysis of Xenopus laevis ovary and somatic cell polyadenylated RNA by molecular hybridization. (1978) (51)
Embryonic expression of the period clock gene in the central nervous system of Drosophila melanogaster. (1986) (51)
Analysis of the C-value paradox by molecular hybridization. (1974) (51)
Yeast U1 snRNP-pre-mRNA complex formation without U1snRNA-pre-mRNA base pairing. (2001) (50)
A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae. (1987) (50)
Age-Related Reduction of Recovery Sleep and Arousal Threshold in Drosophila. (2016) (49)
Circadian rhythms: The cancer connection (2002) (49)
The use of R-looping for structural gene identification and mRNA purification. (1979) (49)
Expression of a Drosophila mRNA is under circadian clock control during pupation. (1989) (48)
The tim SL Mutant Affects a Restricted Portion of the Drosophila melanogaster Circadian Cycle (1998) (48)
Nuclear Export of Heat Shock and Non-Heat-Shock mRNA Occurs via Similar Pathways (2000) (47)
A Constant Light-Genetic Screen Identifies KISMET as a Regulator of Circadian Photoresponses (2009) (46)
Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains. (1990) (46)
Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly. (1991) (46)
Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex (2001) (46)
Identification of Novel Saccharomyces cerevisiaeProteins with Nuclear Export Activity: Cell Cycle-Regulated Transcription Factor Ace2p Shows Cell Cycle-Independent Nucleocytoplasmic Shuttling (2000) (46)
Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression (2011) (45)
A dynamic in vivo view of the HIV-I Rev-RRE interaction. (1997) (45)
Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines. (2001) (45)
Mechanistic implications of enhanced editing by a HyperTRIBE RNA-binding protein (2017) (45)
A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila (2019) (44)
MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila (2017) (44)
Distinct RNA Synthesis Systems of the HeLa Cell (1970) (44)
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression (2016) (43)
Very long-lived messenger RNA in ovaries of Xenopus laevis. (1977) (43)
Genetic and Molecular Analysis of Biological Rhythms (1987) (43)
mRNA nuclear export. (1994) (42)
An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla (1989) (42)
Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila (2019) (42)
Mutational analysis of the interactions between U1 small nuclear RNA and pre-mRNA of yeast. (1989) (41)
Molecular Organization of Drosophila Neuroendocrine Cells by Dimmed (2011) (40)
Transcriptional feedback and definition of the circadian pacemaker in Drosophila and animals. (2007) (39)
Identification and characterization of a yeast homolog of U1 snRNP‐specific protein C (1997) (38)
Membrane-associated protein synthesis of mammalian cells. II. Isopycnic separation of membrane-bound polyribosomes. (1971) (38)
Genes and biological rhythms (1987) (37)
Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein (1996) (37)
Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function. (1990) (37)
Presence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis (1977) (36)
Nonsense-mediated decay does not occur within the yeast nucleus. (2004) (36)
Clk post-transcriptional control denoises circadian transcription both temporally and spatially (2015) (35)
Conservation of cytoplasmic poly(A)-containing RNA in mouse and rat (1975) (35)
Internal state configures olfactory behavior and early sensory processing in Drosophila larvae (2020) (34)
The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear periphery. (2008) (34)
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila (2006) (34)
Alternative branch points are selected during splicing of a yeast pre-mRNA in mammalian and yeast extracts. (1986) (33)
Why the Rat-1 Fibroblast Should Replace the SCN as the In Vitro Model of Choice (1998) (33)
A transcriptomic taxonomy of Drosophila circadian neurons around the clock (2020) (32)
Posttranscriptional regulation and assembly into ribosomes of a Saccharomyces cerevisiae ribosomal protein-beta-galactosidase fusion (1985) (31)
Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity (2019) (31)
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. (2012) (31)
Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons. (1984) (30)
RNA-seq profiling of small numbers of Drosophila neurons. (2015) (30)
A chemical modification/interference study of yeast pre-mRNA spliceosome assembly and splicing. (1988) (30)
Oscillating molecules and how they move circadian clocks across evolutionary boundaries. (1993) (30)
A Targeted Bypass Screen Identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for Stable U1 snRNP/Pre-mRNA Interaction (2009) (29)
4 Yeast Pre-mRNA Splicing (1992) (29)
Regulation of a set of abundant mRNA sequences (1977) (28)
NAT1/DAP5/p97 and Atypical Translational Control in the Drosophila Circadian Oscillator (2012) (28)
Formation of membrane-bound polyribosomes. (1972) (28)
TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression (2019) (28)
Light-Mediated Circuit Switching in the Drosophila Neuronal Clock Network (2019) (27)
Ribosomal protein genes rp 39(10 - 78), rp 39(11 - 40), rp 51, and rp 52 are not contiguous to other ribosomal protein genes in the Saccharomyces cerevisiae genome. (1981) (27)
Co-transcriptional monitoring of mRNP formation (2003) (27)
Characterization of yeast U1 snRNP A protein: identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing. (1996) (26)
DNase I hypersensitive sites of the chromatin for Drosophila melanogaster ribosomal protein 49 gene. (1981) (26)
A yeast splicing factor is localized in discrete subnuclear domains. (1992) (25)
R-looping and structural gene indentification of recombinant DNA. (1979) (25)
U1 snRNP can influence 3'-splice site selection as well as 5'-splice site selection. (1991) (25)
Further evidence that the rna2 mutation of Saccharomyces cerevisiae affects mRNA processing (1982) (25)
Ribosome components are associated with sites of transcription. (2002) (24)
Ribosomal protein mRNAs increase dramatically during Xenopus development. (1981) (24)
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. (2004) (24)
A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons (2017) (24)
Assaying the Drosophila negative feedback loop with RNA interference in S2 cells. (2005) (23)
A Threat to Medical Innovation (2011) (22)
Genetics and molecular biology of rhythms (1987) (22)
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED (2015) (22)
Mapping the clock rhythm mutation to the period locus of Drosophila melanogaster by germline transformation. (1992) (21)
TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals (2020) (21)
Striking circadian neuron diversity and cycling of Drosophila alternative splicing (2018) (21)
Biological clocks in Drosophila: Finding the molecules that make them tick (1985) (20)
TAPping into mRNA Export (2001) (19)
Sporulation and rna2 lower ribosomal protein mRNA levels by different mechanisms in Saccharomyces cerevisiae (1982) (19)
Retraction: PER-TIM Interactions with the Photoreceptor Cryptochrome Mediate Circadian Temperature Responses in Drosophila (2007) (19)
Complementarity between messenger RNA and nuclear RNA from HeLa cells. (1972) (18)
Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)*. (2021) (18)
Yeast pre-mRNA is composed of two populations with distinct kinetic properties. (1996) (17)
A Distinct Visual Pathway Mediates High-Intensity Light Adaptation of the Circadian Clock in Drosophila (2019) (17)
Sequence requirements for branch formation in a group II self-splicing intron. (1989) (16)
MS2-TRIBE Evaluates Both Protein-RNA Interactions and Nuclear Organization of Transcription by RNA Editing (2019) (16)
Differential nuclease sensitivity identifies tight contacts between yeast pre‐mRNA and spliceosomes. (1986) (16)
Blastoderm-specific and read-through transcription of the sry alpha gene transformed into the Drosophila genome. (1986) (15)
Nonreciprocal homeostatic compensation in Drosophila potassium channel mutants. (2017) (14)
Accelerated Degradation of perS Protein Provides Insight into Light-Mediated Phase Shifting (2013) (14)
A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms. (2017) (14)
A Novel Plasmid-Based Microarray Screen Identifies Suppressors of rrp6Δ in Saccharomyces cerevisiae (2006) (14)
The Drosophila period Gene and Dye Coupling in Larval Salivary Glands: A Re-evaluation. (1992) (14)
Circadian rhythms in Drosophila. (2003) (14)
Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock (2017) (14)
Measurement and analysis of yeast pre-mRNA sequence contribution to splicing efficiency. (1990) (14)
Sleep: hitting the reset button (2008) (13)
Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications. (2021) (13)
A comparison of Xenopus laevis oocyte and embryo mRNA. (1981) (12)
Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS (2020) (12)
The precipitation of precursor tRNA in high salt. (1972) (12)
Determination of cellular RNA concentrations by electron microscopy of R loop-containing DNA. (1981) (11)
A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics (2013) (11)
A new twist on clock protein phosphorylation: a conformational change leads to protein degradation. (2011) (11)
Author response: Nascent-Seq reveals novel features of mouse circadian transcriptional regulation (2012) (10)
U1 small nuclear ribonucleoprotein particle-protein interactions are revealed in Saccharomyces cerevisiae by in vivo competition assays (1993) (10)
Accumulation and Behavior of mRNA During Oogenesis and Early Embryogenesis of Xenopus Laevis (1984) (10)
Video Recording Can Conveniently Assay Mosquito Locomotor Activity (2020) (10)
Transposable element landscapes in aging Drosophila (2022) (9)
Circadian oscillations in protein and mRNA levels of the period gene of Drosophila melanogaster. (1991) (9)
Some somatic sequences are absent or exceedingly rare in Xenopus oocyte RNA. (1982) (8)
Comment on “Circadian rhythms in the absence of the clock gene Bmal1” (2021) (8)
Mixed Mechanisms in Yeast Pre-mRNA Splicing? (1996) (8)
Splicing enhancement in the yeast rp51b intron. (2000) (8)
Targeted RNA editing: novel tools to study post-transcriptional regulation. (2021) (7)
Cloning of the two essential yeast genes, PRP6 and PRP9,and their rapid mapping, disruption and partial sequencing using a linker insertion strategy (1991) (7)
Ronald J. Konopka (1947–2015) (2015) (6)
NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila (2018) (6)
Promiscuous or discriminating: Has the favored mRNA target of Fragile X Mental Retardation Protein been overlooked? (2016) (5)
Cell biology. TAPping into mRNA export. (2001) (5)
Recurrent circadian circuitry regulates central brain activity to maintain sleep (2022) (5)
Transfer of dye among salivary gland cells is not affected by genetic variations of the period clock gene in Drosophila melanogaster (1993) (4)
Five suggestions for substantial NIH reforms (2016) (4)
The rna2 mutation of yeast affects the processing of actin mRNA as well as ribosomal protein mRNAs (2004) (4)
Development of a saliva-optimized RT-LAMP assay for SARS-CoV-2 (2021) (4)
The Circadian Clock, Transcriptional Feedback and the Regulation of Gene Expression (2017) (4)
A circadian output circuit controls sleep-wake arousal threshold in Drosophila (2018) (4)
Mutational analysis of the interactions between U1 small nuclear RNA and pre-mRNA of yeast**Presented at the Albany Conference on ‘RNA: Catalysis, Splicing, Evolution’, Rensselaerville, NY (U.S.A.) 22-25 September, 1988. (1989) (3)
Messenger andHeterogeneous Nuclear RNA inHeLaCells: Differential Inhibition byCordycepin* (1970) (3)
Searching for clones with open reading frames. (1987) (3)
Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep (2021) (3)
Long-term dendritic spine stability in the adult cortex (3)
Author response: PDF neuron firing phase-shifts key circadian activity neurons in Drosophila (2014) (3)
Modification of a DNA cloning vehicle to give a high strand-separation melting temperature. (1979) (3)
CRYSTAL STRUCTURE OF BPS-U2 SNRNA DUPLEX (2001) (2)
The DECD box Putative ATPase Sub2p Is an Early mRNA Export Factor (2004) (2)
A biological clock (2003) (2)
Metformin treatment of the C9orf72 ALS/FTD mouse: Almost too good for words (2020) (2)
Functional Analysis of RSS Spacers (2003) (1)
Transposable element landscape changes are buffered by RNA silencing in aging Drosophila (2021) (1)
A yeastsplicing factor islocalized indiscrete subnuclear domains (1992) (1)
Reflections On Contributing To “ Big Discoveries ” About The Fly Clock : Our Fortunate Paths As PostDocs With 2017 Nobel Laureates (2018) (1)
Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain (2022) (1)
Drosophila maternal andembryomRNAstranscribed froma single transcription unit usealternate combinations ofexons (1984) (1)
Prescence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis. (1977) (1)
Monitoring Malaria: Genomic Activity of the Parasite in Human Blood Cells (2003) (1)
Allatostatin C/AstC-R2 is a Novel Pathway to Modulate Circadian Activity Pattern in Drosophila (2018) (1)
Identiﬁcation and Characterization of a Yeast Gene Encoding the U2 Small Nuclear Ribonucleoprotein Particle B (cid:48) Protein (1996) (1)
RiboTRIBE: Monitoring Translation with ADAR-meditated RNA Editing (2021) (1)
Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells (2023) (1)
Protocol for using TRIBE to study RNA-protein interactions and nuclear organization in mammalian cells (2021) (1)
Life Is an N of 1 (2017) (1)
Identification and characterization of a yeast homolog of U 1 snRNP-specific protein (1997) (1)
Author response: Genome-wide identification of neuronal activity-regulated genes in Drosophila (2016) (1)
Expression of a f 3-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna 2 mutation of yeast ( yeast ribosomal protein genes / mRNA splicing / lacZ gene fusions ) (1)
cerevisiae Ul RNA Is Large and Has Limited Primary Sequence Homology to Metazoan Ul snRNA (2003) (1)
in the absence of base pairing (2002) (1)
Faculty Opinions recommendation of Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. (2003) (0)
MOLECULAR ETHOLOGY AND EVOLUTION OF THE PERIOD GENE (1991) (0)
January 2018 TURMERIC AYURVEDA ' S SPICE OF LIFE ® (2021) (0)
Rosbash to transcription elongation mutants In vivo commitment to yeast cotranscriptional splicing is sensitive data (2006) (0)
possible coupling of mRNA processing and chromatin structure . mRNA transport associated with the yeast mutation prp 20 : Defects in mRNA 3 '-end formation , transcription initiation , and (2007) (0)
We'll always have RNA (2015) (0)
A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics (2013) (0)
Behavioral andmolecular analyses suggestthat circadian outputisdisrupted bydisconnected mutants inD.melanogaster (1992) (0)
Faculty Opinions recommendation of Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. (2005) (0)
snRNP A protein : implications for snRNP protein function in An enhancer screen identifies a gene that encodes the yeast U 1 (2007) (0)
Supersensitive Worms Reveal New Gene Functions (2003) (0)
Decision letter: Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation (2020) (0)
Functions and Mechanisms of Sleep in Flies and Mammals (2009) (0)
Protein Provides Insight into Light-Mediated Phase Shifting Sper Accelerated Degradation of (2013) (0)
Contribution of U1 snRNA structural domains to U1 snRNP function (2004) (0)
Pathways Non-Heat-Shock mRNA Occurs via Similar Nuclear Export of Heat Shock and (2000) (0)
Michael Rosbash-Nobel Lecture (2019) (0)
melanogaster . Spatial and temporal expression of the period gene in Drosophila (2007) (0)
Video Recording Can Conveniently Assay Mosquito Locomotor Activity (2020) (0)
Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)** (2021) (0)
Minireview Should Replace the SCN as the In Vitro Model of Choice (1998) (0)
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit (2009) (0)
Perrat Brain Drosophila Transposition-Driven Genomic Heterogeneity in the (2014) (0)
Faculty Opinions recommendation of NXF-2, REF-1, and REF-2 affect the choice of nuclear export pathway for tra-2 mRNA in C. elegans. (2004) (0)
HyperTRIBE identifies many in vivo targets of a RNA-binding protein (2017) (0)
review Genes and biological rhythms (1987) (0)
circadian tissue-specific gene expression CLOCK target gene characterization : implications for Drosophila Material (2011) (0)
New views inside cells with the digital imaging microscope (1991) (0)
Drosophila CLOCK deubiquitylation by USP 8 inhibits CLK / CYC transcription in Material Supplemental (2012) (0)
Table of Contents (1992) (0)
Decision letter: Epigenetic inheritance of circadian period in clonal cells (2020) (0)
bridge between commitment complexes and U 2 snRNP addition . The yeast MUD 2 protein : an interaction with PRP 11 defines a (2007) (0)
Presence of tadpole and adult globin RNA sequences in oocytes of Xen opus laevis ( oogenesis / embryogenesis / complementary DNA / molecular hybridization ) (0)
Widespread post-transcriptional regulation of co-transmission (2023) (0)
Faculty Opinions recommendation of Global gene repression by KaiC as a master process of prokaryotic circadian system. (2004) (0)
BuTT-Seq: a new method for facile profiling of transcription (2023) (0)
Faculty Opinions recommendation of No transcription-translation feedback in circadian rhythm of KaiC phosphorylation. (2004) (0)
Dissecting cell-specific functions of circadian genes using modified cell-specific CRISPR approaches (2023) (0)
Nobel Laureate Series What Makes Us Tick? (2020) (0)
Saccharomyces cerevisiae Ul small nuclear RNA secondary structure contains both universal and yeast-specific domains ( phylogenetic studies / splicing ) (0)
Faculty Opinions recommendation of Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC. (2004) (0)
Results Genome-wide analysis of transcription in the mouse liver using Nascent-Seq (2012) (0)
New Genomic Approach Predicts True Evolutionary History of Bacterial Genomes (2003) (0)
Saccharomyces cerevisiae. A novel role for the 3' region of introns in pre-mRNA splicing of (2010) (0)
Animal Physiology and Circadian Photoresponses (2011) (0)
Circadian rhythms in Drosophila: Molecules, Cells and Systems (2003) (0)
nuclear cap-binding complex . component and corresponds to CBP 20 , the small subunit of the The yeast splicing factor Mud 13 p is a commitment complex (2007) (0)
HyperTRIBE: Upgrading TRIBE with enhanced editing (2017) (0)

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