Michael Steven Denison

Michael Steven Denison's AcademicInfluence.com Rankings

Earth Sciences

#1598

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#2279

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Environmental Science

#149

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#151

Historical Rank

earth-sciences Degrees

Michael Steven Denison

Biology

#10223

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#13531

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Ecology

#582

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#637

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Neuroscience

#1568

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#1619

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biology Degrees

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Earth Sciences
Biology

Michael Steven Denison's Degrees

PhD Toxicology University of California, Berkeley
Masters Environmental Science Stanford University

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Michael Steven Denison's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. (2006) (3169)
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. (2003) (1750)
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells (2010) (931)
Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (2011) (615)
Aryl hydrocarbon receptor control of a disease tolerance defence pathway (2014) (502)
Ligand binding and activation of the Ah receptor. (2002) (467)
The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. (1988) (409)
Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. (1996) (377)
Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity* (1999) (371)
Xenobiotic-inducible Transcription of Cytochrome P450 Genes (*) (1995) (364)
Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. (1996) (358)
In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens (2008) (335)
Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. (1998) (294)
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. (1995) (281)
Activation of the Ah receptor by tryptophan and tryptophan metabolites. (1998) (278)
The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals (1998) (263)
Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. (1996) (249)
CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. (2010) (216)
Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer. (1988) (211)
Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex. (1989) (209)
Induction of Cyp1a1 Is a Nonspecific Biomarker of Aryl Hydrocarbon Receptor Activation: Results of Large Scale Screening of Pharmaceuticals and Toxicants in Vivo and in Vitro (2007) (201)
Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. (2013) (178)
Species-specific antagonism of Ah receptor action by 2,2',5,5'-tetrachloro- and 2,2',3,3'4,4'-hexachlorobiphenyl. (1995) (176)
Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. (1999) (169)
Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols. (1986) (168)
Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response (2013) (165)
Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. (2000) (156)
Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water. (2017) (156)
Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. (2004) (153)
Activation of the Ah Receptor Signaling Pathway by Prostaglandins (2001) (144)
Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling. (2015) (141)
Relationship between Estrogen Receptor-Binding and Estrogenic Activities of Environmental Estrogens and Suppression by Flavonoids (2002) (141)
DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer. (1992) (128)
Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis. (2007) (124)
Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. (2003) (123)
Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. (2013) (123)
Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis. (2009) (116)
Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. (2008) (108)
Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. (2000) (107)
Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists. (2002) (107)
Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. (2004) (105)
Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis (2014) (104)
Development of basal and induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the chicken embryo in ovo. (1983) (103)
Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells. (2004) (102)
Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. (2000) (101)
Comparison of recombinant cell bioassays for the detection of Ah receptor agonists (2004) (100)
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins (2004) (100)
Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. (2005) (98)
Induction of drug-metabolizing enzymes: mechanisms and consequences. (1986) (96)
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. (1993) (95)
Analysis of Ah receptor pathway activation by brominated flame retardants. (2004) (90)
Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays. (1996) (88)
Organization and function of a dioxin-responsive enhancer. (1990) (86)
Ultraviolet photoproducts of tryptophan can act as dioxin agonists. (1991) (86)
Atmospheric concentrations of polybrominated diphenyl ethers at near-source sites. (2007) (85)
Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout (1995) (84)
Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. (2006) (81)
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation (2006) (80)
Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. (1998) (77)
Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. (1998) (76)
Neutrophil function after exposure to polychlorinated biphenyls in vitro. (1993) (76)
The calux (chemical‐activated luciferase expression) assay adapted and validated for measuring TCDD equivalents in blood plasma (1997) (75)
Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor* (2008) (75)
The in vivo estrogenic and in vitro anti‐estrogenic activity of permethrin and bifenthrin (2012) (73)
New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability (2011) (72)
Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. (2000) (69)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species (1986) (68)
And Now for Something Completely Different: Diversity in Ligand-Dependent Activation of Ah Receptor Responses. (2017) (68)
Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer. (1992) (68)
Persistent binding of ligands to the aryl hydrocarbon receptor. (2007) (66)
Induction of Cytochrome P450 Enzymes That Metabolize Xenobiotics (1995) (66)
Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. (2011) (66)
Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. (1996) (66)
Toxicology in the Fast Lane: Application of High-Throughput Bioassays to Detect Modulation of Key Enzymes and Receptors (2009) (64)
An in vitro rainbow trout cell bioassay for aryl hydrocarbon receptor‐mediated toxins (1997) (63)
The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. (2002) (61)
Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. (2013) (61)
Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. (2002) (61)
Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma (2018) (60)
Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease. (2018) (59)
Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer. (1991) (57)
Identification of the Ah receptor in selected mammalian species and induction of aryl hydrocarbon hydroxylase. (1985) (55)
Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection Limits. (2015) (53)
Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells. (2016) (52)
Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. (2000) (50)
Production of a novel recombinant cell line for use as a bioassay system for detection of 2,3,7,8‐tetrachlorodibenzo‐P‐dioxin‐like chemicals (1994) (50)
Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. (1996) (50)
Hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial stabilization by molybdate. (1986) (50)
Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. (2013) (48)
Analysis of the murine AhR gene promoter (2000) (48)
Analysis of the Aryl Hydrocarbon Receptor (AhR) Signal Transduction Pathway (2002) (48)
Modeling the binding of diverse ligands within the Ah receptor ligand binding domain (2019) (48)
Comparative gene responses to collected ambient particles in vitro: endothelial responses. (2011) (48)
Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. (2002) (47)
Pityriazepin and other potent AhR ligands isolated from Malassezia furfur yeast. (2015) (44)
Gas-Phase Ambient Air Contaminants Exhibit Significant Dioxin-like and Estrogen-like Activity in Vitro (2005) (44)
Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: evidence for two distinct heteromeric DNA-binding forms. (1993) (44)
Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes. (2002) (43)
A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein. (2012) (43)
Trace contamination with dioxin-like chemicals: evaluation of bioassay-based TEQ determination for hazard assessment and regulatory responses (2001) (42)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: ontogeny in chick embryo liver. (1986) (42)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Codistribution of unoccupied receptor with cytosolic marker enzymes during fractionation of mouse liver, rat liver and cultured Hepa-1c1 cells. (1986) (42)
AHR Ligands: Promiscuity in Binding and Diversity in Response (2011) (41)
Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain* (2011) (41)
Inhibition of intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like PCBs in mouse hepatoma cells (Hepa1c1c7): involvement of the Ah receptor. (1994) (40)
The binding of transformed aromatic hydrocarbon (Ah) receptor to its DNA recognition site is not affected by metal depletion (1990) (40)
Characterization and potential environmental risks of leachate from shredded rubber mulches. (2009) (40)
From ‘Omics to Otoliths: Responses of an Estuarine Fish to Endocrine Disrupting Compounds across Biological Scales (2013) (39)
Chemicals having estrogenic activity can be released from some bisphenol a-free, hard and clear, thermoplastic resins (2014) (39)
Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. (2013) (37)
Newspapers and newspaper ink contain agonists for the ah receptor. (2008) (37)
Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. (2011) (37)
Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. (2012) (36)
Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation. (1983) (36)
In vitro transformation of the human Ah receptor and its binding to a dioxin response element. (1992) (35)
Transient expression of CYP1A1 in rat epithelial cells cultured in suspension. (2001) (35)
Ah-receptor mediated luciferase expression: a tool for monitoring dioxin-like toxicity. (1993) (34)
Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds (2010) (33)
Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists Structure–Activity Relationships and Receptor Modeling (2017) (33)
Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species. (1985) (32)
Dioxinlike properties of a trichloroethylene combustion-generated aerosol. (1996) (32)
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. (2015) (31)
Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts (2011) (30)
Identification of a Novel Cis-acting Negative Regulatory Element Affecting Expression of the CYP1A1 Gene in Rat Epidermal Cells* (1996) (30)
Protein kinase C is not involved in Ah receptor transformation and DNA binding. (1993) (30)
Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. (2013) (30)
The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation. (2011) (29)
Estrogenic Activity Measurements in Water Using Diffusive Gradients in Thin-Film Coupled with an Estrogen Bioassay. (2017) (29)
Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon Receptor (2014) (29)
Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border. (2003) (28)
Interaction of diuron and related substituted phenylureas with the Ah receptor pathway (2006) (28)
Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation (2016) (28)
Mechanism-based common reactivity pattern (COREPA) modelling of aryl hydrocarbon receptor binding affinity (2010) (27)
The hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: species differences in subunit dissociation. (1990) (27)
Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propiconazole (1999) (26)
Common Commercial and Consumer Products Contain Activators of the Aryl Hydrocarbon (Dioxin) Receptor (2013) (26)
CALUX measurements: statistical inferences for the dose-response curve. (2011) (25)
Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons (2002) (25)
Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. (2012) (25)
In situ measurement of estrogenic activity in various aquatic systems using organic diffusive gradients in thin-film coupled with ERE-CALUX bioassay. (2019) (25)
Structure and function of the Ah receptor: sulfhydryl groups required for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to cytosolic receptor from rodent livers. (1987) (24)
Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. (2006) (24)
Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. (2014) (24)
Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. (1997) (24)
Microsomal Aryl Hydrocarbon Hydroxylase Comparison of the Direct, Indirect and Radiometric Assays (1983) (24)
In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride (2017) (23)
DNA binding of the transformed guinea pig hepatic Ah receptor complex: identification and partial characterization of two high-affinity DNA-binding forms. (1995) (23)
Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist (2018) (23)
Production of novel recombinant cell line bioassay systems for detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. (1993) (22)
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription. (2011) (22)
Characterisation and implementation of the ERE-CALUX bioassay on indoor dust samples of kindergartens to assess estrogenic potencies (2016) (22)
Environmental Estrogens in Agricultural Drain Water from the Central Valley of California (1998) (21)
Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor α and β for improved detection of estrogenic/antiestrogenic chemicals (2016) (21)
Persistent vitellogenin-like protein and binding of DDT in the serum of insecticide-resistant mosquitofish (Gambusia affinis). (1981) (21)
PCBs contamination in seafood species at the Eastern Coast of Thailand. (2009) (21)
Specific ligand binding domain residues confer low dioxin responsiveness to AHR1β of Xenopus laevis. (2013) (21)
Induction of hepatic cytochrome P450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1989) (20)
Analysis of dioxins in contaminated soils with the CALUX and CAFLUX bioassays, an immunoassay, and gas chromatography/high‐resolution mass spectrometry (2007) (20)
Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser Transmontamus) (2009) (20)
Induction of Cyp 1 a 1 Is a Nonspecific Biomarker of Aryl Hydrocarbon Receptor Activation : Results of Large Scale Screening of Pharmaceuticals and Toxicants in Vivo and in Vitro (2007) (19)
Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells. (2015) (19)
Protamine sulfate precipitation: a new assay for the Ah receptor. (1984) (19)
Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. (2015) (19)
METHYLATED PAHS AND/OR THEIR METABOLITES ARE IMPORTANT CONTRIBUTORS TO THE OVERALL ESTROGENIC ACTIVITY OF PAH-CONTAMINATED SOILS (2017) (19)
Effect of in utero and postnatal exposure to environmental tobacco smoke on the developmental expression of pulmonary cytochrome P450 monooxygenases (2000) (18)
Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. (2009) (18)
Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. (2010) (18)
Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter (2015) (18)
Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization. (2017) (17)
The Ah receptor can bind ligand in the absence of receptor-associated heat-shock protein 90. (1998) (17)
Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2) (2015) (17)
Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. (2002) (17)
2,3-cis-2R,3R-(−)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines (2013) (16)
DNA Binding (Gel Retardation Assay) Analysis for Identification of Aryl Hydrocarbon (Ah) Receptor Agonists and Antagonists (2014) (16)
Assessing the receptor-mediated activity of PAHs using AhR-, ERα- and PPARγ- CALUX bioassays. (2020) (16)
Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: Optimization and validation of a new CALUX bioassay method. (2011) (16)
The CALUX bio-assay: analytical comparison between mouse hepatoma cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin response elements. (2011) (16)
Application of the CALUX (chemical activated luciferase gene expression) assay for measuring TCDD-equivalents in sediment, pore water and blood plasma samples. (1996) (16)
Dioxins, furans and dioxin-like PCBs in sediment samples and suspended particulate matter from the Scheldt estuary and the North Sea Coast: Comparison of CALUX concentration levels in historical and recent samples. (2018) (15)
Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data. (2007) (15)
Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols (2019) (15)
Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks. (2009) (15)
Application of the luciferase cell culture bioassay for the detection of refined petroleum products. (2002) (14)
Toxicant-Receptor Interactions : Modulations of signal transduction and gene expression (1998) (14)
Ginsenosides Are Novel Naturally-Occurring Aryl Hydrocarbon Receptor Ligands (2013) (14)
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. (2012) (14)
Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure. (2014) (14)
Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events (2019) (14)
Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II. (2011) (13)
Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity (2009) (13)
Endocrine activity in an urban river system and the biodegradation of estrogen-like endocrine disrupting chemicals through a bio-analytical approach using DRE- and ERE-CALUX bioassays. (2018) (12)
Species-specific antagonism of Ah receptor action by 2,2',5,5'-tetrachlorobiphenyl. (1993) (12)
Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: correlation between the CALUX bioassay and GC-HRMS. (2012) (12)
In vitro and in silico derived relative effect potencies of ah-receptor-mediated effects by PCDD/Fs and PCBs in rat, mouse, and guinea pig CALUX cell lines. (2014) (12)
The molecular mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons (1991) (12)
Elimination of interfering compounds in preparation for analysis by an Ah receptor based bioassay (2002) (12)
An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. (2015) (12)
Transitional States in Ligand-Dependent Transformation of the Aryl Hydrocarbon Receptor into Its DNA-Binding Form (2020) (12)
Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP 1 A gene expression (2000) (11)
A biomimetic, one-step transformation of simple indolic compounds to Malassezia-related alkaloids with high AhR potency and efficacy. (2019) (11)
Time-integrated monitoring of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in urban and industrial wastewaters using a ceramic toximeter and the CALUX bioassay. (2014) (11)
Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon–contaminated soils (2018) (10)
Regulation of cytochrome P1-450 gene expression in mouse hepatoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1989) (10)
Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. (2016) (10)
Identification of the Herbicide Surflan and Its Active Ingredient Oryzalin, a Dinitrosulfonamide, as Xenoestrogens (2005) (10)
Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells. (1999) (10)
Down-regulation of cytochrome P450 1A1 by monomethylarsonous acid in human HepG2 cells. (2017) (10)
Assessment of estrogenic compounds in paperboard for dry food packaging with the ERE-CALUX bioassay. (2019) (10)
Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. (2014) (9)
Rapid extraction of total lipids and lipophilic POPs from all EU-regulated foods of animal origin: Smedes’ method revisited and enhanced (2020) (9)
Recovery determinations for bioassay analysis : Considerations and results (2002) (9)
Heterogeneity of rat hepatic Ah receptor: identification of two receptor forms which differ in their biochemical properties. (1992) (9)
Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay (2004) (9)
REVISED EU-CRITERIA FOR APPLYING BIOANALYTICAL METHODS FOR SCREENING OF FEED AND FOOD FOR DIOXINS AND DIOXIN-LIKE PCBS. (2010) (9)
Dioxin analysis in water by using a passive sampler and CALUX bioassay. (2012) (9)
Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. (2003) (8)
Cell-based assays for identification of aryl hydrocarbon receptor (AhR) activators (2014) (8)
Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. (2016) (8)
Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. (2002) (8)
Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay (2017) (8)
Gene mdpC plays a regulatory role in the methyl-tert-butyl ether degradation pathway of Methylibium petroleiphilum strain PM1. (2015) (8)
Species-specific differences in Ah receptor ligand binding and transcriptional activation: implications for bioassays for the detection of dioxin-like chemicals. (1995) (8)
Nuclear Ah receptor from mouse hepatoma cells: effect of partial proteolysis on relative molecular mass and DNA-binding properties. (1990) (8)
Assessing the biological reactivity of organic compounds on volcanic ash: implications for human health hazard (2021) (8)
Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge. (2021) (8)
Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls (2016) (8)
Assessment of estrogenic activity in PM₁₀ air samples with the ERE-CALUX bioassay: Method optimization and implementation at an urban location in Flanders (Belgium). (2016) (7)
High throughput in vitro and in vivo screening of inland waters of Southern California. (2017) (7)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver: lack of sensitivity to alkaline phosphatase when compared with that of glucocorticoid receptor. (1989) (7)
Rapid bioassay for the determination of dioxins and dioxin-like PCDFs and PCBs in meat and animal feeds. (2005) (7)
Correlation between the high expression of C/EBPβ protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3‐L1 cells (2002) (7)
Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. (2017) (6)
Identifying Toxicologically Significant Compounds in Urban Wildfire Ash Using In Vitro Bioassays and High-Resolution Mass Spectrometry. (2021) (6)
The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor (2020) (5)
Time-integrated monitoring of dioxin-like polychlorinated biphenyls (dl-PCBs) in aquatic environments using the ceramic toximeter and the CALUX bioassay. (2014) (5)
Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 and AHR2 in the red seabream (Pagrus major) (2016) (5)
Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. (2002) (5)
Recombinant cell lines for the detection of dioxins and Ah receptor ligands : Not all assays are created equal (2002) (5)
Persistent Organic Pollutants (POPs) and Immune Function in US Atlantic Coast Harbor Seals (Phoca vitulina concolor ) (2003) (5)
A green fluorescent protein based recombinant cell bioassay for the detection of activators of the aryl hydrocarbon receptor : Application for screening of a 1,5-dialkylamino-2,4-dinitrobenzene combinatorial chemical library (2000) (4)
Characterization of hsp90‐binding to the the PASB domain of the Ah receptor (2006) (4)
Activation of AH and estrogen receptor-based cell bioassay systems by extracts of natural dietary herbal supplements (2000) (4)
Assessing the estrogenic activity of chemicals present in resin based dental composites and in leachates of commercially available composites using the ERα-CALUX bioassay. (2021) (4)
Mechanism based common reactivity pattern (COREPA) modeling of AhR binding affinity (2010) (4)
Ah RECEPTOR-BASED BIOASSAYS FOR DIOXINS AND RELATED CHEMICALS: APPLICATIONS AND LIMITATIONS. (1999) (3)
DISCREPANCIES BETWEEN BIO-ANALYTICAL AND CHEMO-ANALYTICAL RESULTS HAVE A NON-NEGLIGIBLE MESSAGE (2010) (3)
Surrogates for dioxin analyses : Analytical, elisa and toxicological aspects (2000) (3)
Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam. (2021) (3)
Antagonistic effects of diortho PCBs (PCB 52 and 128) on Ah receptor-mediated induction of luciferase activity by 3,3',4,4'-tetrachlorobiphenyl (PCB 77) in mouse Hepa-1c1c7 cells. (1993) (3)
Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells. (2020) (3)
Binding of insecticides to serum proteins in mosquitofish (Gambusia affinis). (1985) (2)
Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons (2002) (2)
Short-term interactions between DDT and endrin accumulation and elimination in mosquitofish (Gambusia affinis) (1985) (2)
DNA sequence-specific binding of transformed Ah receptor to a dioxin responsive enhancer : looks Aren't everything (1992) (2)
Toxic Equivalency Factors for Dioxins and Dioxin-like Compounds 2 3 (2006) (2)
Synergistic activation of ah receptor-dependent gene expression by activators of protein kinase C (2000) (2)
Tryptophan metabolites, indole-3-pyruvic acid, DL-3- indolelactic acid, L-kynurenine, and kynurenic acid activate ah receptor signal transduction (2000) (2)
Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer (2022) (2)
Analysis of PCDD/Fs and dioxin-like PCBs in sewage sludges and general bio-wastes available for agricultural land application in Belgium - comparison between GC-IDHRMS and CALUX results (2012) (2)
Induction of hepatic microsomal cytochrome P-450 and associated monooxygenases by pentamethylbenzene in the rat. (1983) (2)
Ah receptor mediated effects of particulate organic extracts from the Paso del Norte airshed along the U.S. - Mexico border (2000) (2)
SMRT mediated transcriptional silencing of the AH receptor signaling pathway not observed in human MCF-7 or BG-1 cell lines (2000) (2)
NEW CUT-OFF VALUES FOR APPLICATIONS IN BIOANALYTICAL SCREENING: DECISION OVER SAMPLE COMPLIANCE WITH LEGAL LIMITS SET BY THE EUROPEAN UNION FOR PCDD/Fs AND DIOXIN-LIKE PCBs (2010) (2)
Nickel and nickel-conjugate metabolism and acute toxicity. (1989) (1)
1057 Vemurafenib acts as an aryl hydrocarbon receptor antagonist (2018) (1)
VALIDATION OF THE LUMI-CELL™ ER RECOMBINANT BIOASSAY FOR RAPID EVALUATION OF CHEMICALS FOR POTENTIAL ESTROGENIC ACTIVITY (2003) (1)
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation. (2021) (1)
Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells. (2002) (1)
Identification and characterization of novel flavone agonists of the Ah receptor (2003) (1)
onsiderations for potency equivalent calculations in the Ah receptor-based ALUX bioassay : Normalization of superinduction results for improved sample otency estimation avid (2010) (1)
Editorial overview: The aryl hydrocarbon (Ah) receptor: From toxicology to human health (2017) (1)
LUMI-CELL™ ER, A RECOMBINANT BIOASSAY FOR RAPID EVALUATION OF POTENTIAL ESTROGENIC ENDOCRINE DISRUPTOR CHEMICALS (2004) (1)
Screening for aryl hydrocarbon receptor activity in ambient air using passive sampling (SPMDS) and CAFLUX (2007) (1)
New insights into the structure of the mahr ligand binding domain (2002) (1)
Synthesis of a ligand–quencher conjugate for the ligand binding study of the aryl hydrocarbon receptor using a FRET assay (2012) (1)
Application of a human ovarian cell bioassay for the detection and analysis of estrogen-toxicant interactions (2000) (1)
Validation of a cell culture bioassay for detection of petroleum exposure in mink (Mustela vison) as a model for detection in sea otters (Enhydra lutris). (2002) (1)
Progressive silencing of CYP1A1 induction in rat keratinocytes (2000) (1)
Testing structure-binding predictions from comparative modeling of the AHR ligand-binding domain: Studies with zebrafish AHR1a (2011) (1)
Revealed by Site-Directed Mutagenesis Receptor Agonists and Antagonists Ligand Promiscuity of Aryl Hydrocarbon (2014) (1)
An Aryl Hydrocarbon Receptor from the Caecilian Gymnopis multiplicata Suggests Low Dioxin Affinity in the Ancestor of All Three Amphibian Orders (2019) (1)
Do PCDD/PCDF standard solutions used in dioxin analysis pose a risk as potentially acutely toxic to lab personnel? (2017) (1)
Myeloperoxidase-Dependent Nitration and Oxidation ofp-Cresol: A Novel Pathway for Xenobiotic Metabolism. (2009) (0)
Activation of the ah receptor and ah receptor signal transduction pathway by tryptophan-derived agonists (2003) (0)
Neonicotinoids induce a promoter-switchin CYP19 expression in breast-cancer cells and alter aromatase activity and hormoneproduction in a feto-placental co-culture model (2016) (0)
Extraction and bioanalysis of arylhydrocarbon- and estrogen- receptor active compounds (1997) (0)
Physiocochemical characterization of the cytosolic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (1985) (0)
PROCESS OF VALIDATION OF THE LUMI-CELL™ ER RECOMBINANT BIOASSAY FOR RAPID EVALUATION OF POTENTIAL ESTROGENIC ENDOCRINE DISRUPTOR CHEMICALS (2004) (0)
Brussel Endocrine activity in waste and river waters from the Brussels Region , Belgium using the BG 1 Luc 4 E 2 CALUX Bioassay (2018) (0)
CHARACTERIZATION OF THE CALUX AND GRAB BIOASSAYS FOR SENSITIVITY AND SPECIFICITY IN DETECTION OF PHARMACOLOGICAL AGENTS THAT ACTIVATE THE Ah RECEPTOR SIGNALING SYSTEM (2007) (0)
Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma (2018) (0)
Combined genotoxic effect of arsenic, cadmium, chromium and four polyaromatic hydrocarbons (2015) (0)
Archives of Biochemistry and Biophysics (2015) (0)
Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 and AHR2 in the red seabream (Pagrus major) (2016) (0)
An Aryl Hydrocarbon Receptor Sequence from the Caecilian Gymnopis multiplicata Exhibits Low Responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2018) (0)
Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2) (2014) (0)
Molecular characterization of the Ah-receptor pathway in flounder (Platichtys flesus). (1998) (0)
Screening and analysis of novel naphthoflavone ligands for the Ah receptor (2003) (0)
UC Office of the President Recent Work Title Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma Permalink (2018) (0)
States in Ligand-Dependent Transformation of the Aryl Receptor into Its DNA-Binding Form. (2020) (0)
Bioanalytical screening of low levels of dioxins and dioxin-like PCBs in pig meat (pork) for checking compliance with EU maximum and action levels using highly sensitive “third generation” recombinant H4L7.5c2 rat hepatoma cells (2021) (0)
Analysis of Soil Samples from a Hazardous Waste Site : Comparison of CALUX ® Bioassay TEQ Determinations with High Resolution GC / MS (2002) (0)
Determination of Androgenic activity on a stably transfected human breast cell line (2006) (0)
A model for functional analyses of coadaptor involvement in dioxin-inducible gene expression (2000) (0)
Growth regulation by ahr ligands in the human mammary epithelial cell line MCF-10A (2000) (0)
Easy transformation of indoles to substituted tryptanthrins with powerful AHR activity (2012) (0)
Isolation of malassezia metabolites with powerful AHR activity from human skin. is there implication in skin cancer development (2012) (0)
Molecular Mechanism of Dioxin Action: Molecular Cloning of the Ah Receptor Using a DNA Recognition Site Probe (1992) (0)
Binding specificity of diverse AhR ligands interpreted by Molecular Modeling (2016) (0)
Role of chelatable metal ions in aryl hydorcarbon receptor (AhR) function (2000) (0)
Modeling the binding of diverse ligands within the Ah receptor ligand binding domain (2019) (0)
22nd International Symposium on Environmental Halogenated Organic Pollutants and POPs Barcelona, Spain, August 12–16, 2002 (2002) (0)
Brussel In vitro reporter gene activity of PCDD / Fs and dl-PCBs in wood ash from domestic heating systems ( Belgium ) using the H 1 L 7 . 5 c 1 CALUX Bioassay (2018) (0)
Deciphering the ahr:arnt dimerization process: how to assembly the functional puzzle of interacting interfaces (2016) (0)
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Subunit dissociation and inactivation of ligand binding in conditions of high ionic strength (1985) (0)
Identification of novel agonists and antagonists of the Ah receptor signal transduction pathway (2003) (0)
Polyoxymethylene (POM) is a suitable tool for 1 effect-based hazard 2 assessment of PAC-contaminated soil (2018) (0)
Dioxin exposure and effects assessment of red-tailed tropicbirds nesting on Johnston Island, central pacific ocean (2000) (0)
Synthesis of a ligand–quencher conjugate for the ligand binding study of the aryl hydrocarbon receptor using a FRET assay (2011) (0)
Brevetoxin: Biotransformation and effects on xenobiotic metabolizing enzymes (1996) (0)
Specific amino acid residues within the ligand binding domain confer low responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to an aryl hydrocarbon receptor (AHR) from the frog Xenopus Laevis (2011) (0)
FACTOR-Receptor and the Inflammatory Response : Cross-talk between Aryl Hydrocarbon Gene Regulation : (2014) (0)
Ontogeny of the cytosolic TCDD receptor in the chick embryo and neonate (1984) (0)
Boitano Human Hematopoietic Stem Cells Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of (2012) (0)
Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter (2015) (0)
NF-κB is involved in cross-talk between ah-receptor and signal transduction pathways (2002) (0)

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