Michael S. Krangel

Michael S. Krangel's AcademicInfluence.com Rankings

Michael S. Krangel

Biology

#11455

World Rank

#14853

Historical Rank

Immunology

#759

World Rank

#781

Historical Rank

Genetics

#1424

World Rank

#1526

Historical Rank

Molecular Biology

#2139

World Rank

#2172

Historical Rank

biology Degrees

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Biology

Michael S. Krangel's Degrees

Masters Biochemistry Stanford University

Why Is Michael S. Krangel Influential?

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According to Wikipedia, Michael Steven Krangel is an American immunologist. He is the Mary Bernheim Distinguished Professor of Immunology in the Department of Immunology at the Duke University School of Medicine. In 2010, Krangel was appointed chair of the Department of Immunology at Duke University School of Medicine.

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Michael S. Krangel's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Identification of a putative second T-cell receptor (1986) (930)
Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. (1992) (780)
Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes (1987) (351)
A role for histone acetylation in the developmental regulation of VDJ recombination. (2000) (310)
Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. (1987) (274)
A role for cohesin in T cell receptor rearrangement and thymocyte differentiation (2011) (241)
Assembly and maturation of HLA-A and HLA-B antigens in vivo (1979) (225)
Mechanics of T cell receptor gene rearrangement. (2009) (224)
Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway (1986) (208)
Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation (1987) (184)
Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes (2002) (180)
Identification of putative human T cell receptor delta complementary DNA clones. (1987) (179)
Gene segment selection in V(D)J recombination: accessibility and beyond (2003) (173)
Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors (1994) (169)
Chemokines have diverse abilities to form solid phase gradients. (2001) (157)
The γδT Cell Receptor (1988) (149)
The human cytokine I-309 is a monocyte chemoattractant. (1992) (143)
Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. (1984) (136)
Expression of multiple chemokine genes by a human mast cell leukemia. (1994) (133)
Noncoding transcription controls downstream promoters to regulate T‐cell receptor α recombination (2007) (129)
A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production (1990) (128)
c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer (1995) (116)
Targeted inhibition of V(D)J recombination by a histone methyltransferase (2004) (114)
Diversity and organization of human T cell receptor delta variable gene segments (1989) (110)
Identification of a Glycosaminoglycan-binding Site in Chemokine Macrophage Inflammatory Protein-1α* (1997) (108)
The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. (1994) (106)
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. (2002) (106)
A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. (1990) (104)
Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility (2002) (103)
Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. (1992) (102)
A novel polypeptide secreted by activated human T lymphocytes. (1989) (99)
Extensive junctional diversity of rearranged human T cell receptor delta genes. (1988) (98)
Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus (2004) (97)
Regulation of T cell receptor-α gene recombination by transcription (2006) (94)
An enhancer-blocking element between α and δ gene segments within the human T cell receptor α/δ locus (1997) (94)
Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers (1994) (93)
Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene (1994) (92)
Genomic organization of the human T-cell antigen-receptor alpha/delta locus. (1988) (91)
Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta. (1999) (86)
A Developmental Switch from TCRδ Enhancer to TCRα Enhancer Function during Thymocyte Maturation (1999) (84)
A Change in the Structure of Vβ Chromatin Associated with TCR β Allelic Exclusion1 (2002) (82)
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination (2010) (82)
Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes. (1987) (82)
Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments (2008) (80)
Chemokine Production by G Protein-Coupled Receptor Activation in a Human Mast Cell Line: Roles of Extracellular Signal-Regulated Kinase and NFAT1 (2000) (79)
T cell development: better living through chromatin (2007) (77)
Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub (2012) (77)
Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules. (1980) (77)
Enhancer control of local accessibility to V(D)J recombinase (1997) (72)
Two forms of HLA class I molecules in human plasma. (1987) (72)
Interleukin-7 co-ordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection (2015) (68)
Regulation of TCR δ and α repertoires by local and long-distance control of variable gene segment chromatin structure (2005) (67)
Regulation of T cell receptor β allelic exclusion at a level beyond accessibility (2005) (67)
Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. (2004) (67)
T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex (2007) (65)
Cooperation among Multiple Transcription Factors Is Required for Access to Minimal T-Cell Receptor α-Enhancer Chromatin In Vivo (1998) (63)
Regulation of T cell receptor-alpha gene recombination by transcription. (2006) (62)
Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. (1991) (62)
A Distinct Wave of Human T Cell Receptor y / b Lymphocytes in the Early Fetal Thymus : Evidence for Controlled Gene Rearrangement and Cytokine Production (1990) (62)
Delineation of immunologically and biochemically distinct HLA-A2 antigens. (1982) (60)
Regulation of T cell receptor α gene assembly by a complex hierarchy of germline Jα promoters (2005) (59)
Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region. (1983) (59)
Developmental regulation of V(D)J recombination at the TCR a/5 locus (1998) (57)
IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte -selection (2015) (55)
Turning T‐cell receptor β recombination on and off: more questions than answers (2006) (53)
Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. (1990) (52)
Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination (2010) (51)
Structural Analysis of the Functional Sites of Class I HLA Antigens (1985) (50)
The gamma delta T cell receptor. (1988) (50)
Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1. (1982) (49)
T-cell receptors of human suppressor cells (1987) (49)
Developmental Regulation of VDJ Recombination By the Core Fragment of the T Cell Receptor α Enhancer (1997) (49)
Regulation of T cell receptor delta gene rearrangement by c-Myb (1996) (48)
Germline transcription: a key regulator of accessibility and recombination. (2009) (48)
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element (2015) (48)
Regulation of I‐309 gene expression in human monocytes by endogenous interleukin‐1 (1997) (46)
Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. (1987) (46)
CD69 Gene Is Differentially Regulated in T and B Cells by Evolutionarily Conserved Promoter-Distal Elements1 (2009) (44)
T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. (1987) (43)
A discrete chromatin loop in the murine Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires (2015) (43)
Regulation of T Cell Receptor δ Gene Rearrangement by CBF/PEBP2 (1997) (40)
Unusual RNA splicing generates a secreted form of HLA‐A2 in a mutagenized B lymphoblastoid cell line. (1985) (40)
Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes. (1984) (40)
Role for rearranged variable gene segments in directing secondary T cell receptor α recombination (2007) (39)
Chromatin Architecture, CCCTC-Binding Factor, and V(D)J Recombination: Managing Long-Distance Relationships at Antigen Receptor Loci (2013) (39)
An anti-silencer– and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development (2015) (38)
Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. (1999) (37)
Transcription-Dependent Mobilization of Nucleosomes at Accessible TCR Gene Segments In Vivo (2010) (37)
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. (2007) (37)
Regulation of the Murine Dδ2 Promoter by Upstream Stimulatory Factor 1, Runx1, and c-Myb1 (2005) (35)
An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus. (1997) (35)
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. (2012) (35)
Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. (2015) (34)
Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development (2016) (33)
V(D)j Recombination Becomes Accessible (2001) (32)
Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response (2016) (32)
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2 (2013) (32)
A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus. (2018) (32)
Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. (2005) (31)
Distinct Roles for c-Myb and Core Binding Factor/Polyoma Enhancer-Binding Protein 2 in the Assembly and Function of a Multiprotein Complex on the TCR δ Enhancer In Vivo1 (2002) (31)
Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. (2012) (29)
Multiple Constraints at the Level of TCRα Rearrangement Impact Vα14i NKT Cell Development1 (2007) (28)
Recognition of HLA-A2 mutant and variant target cells by an HLA-A2 allospecific human cytotoxic T lymphocyte line. (1983) (27)
Structural analysis of HLA-A2 antigen from immunoselected mutant 8.6.1: further definition of an HLA-A2-specific serological determinant. (1983) (26)
A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion. (2002) (26)
HLA antigen structural gene mutants selected with an allospecific monoclonal antibody. (1982) (26)
Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization (2011) (26)
Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination. (1999) (25)
Allele-Specific Regulation of TCRβ Variable Gene Segment Chromatin Structure1 (2005) (25)
Accessibility control of T cell receptor gene rearrangement in developing thymocytes (2000) (23)
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53 (2016) (23)
Turning T-cell receptor beta recombination on and off: more questions than answers. (2006) (23)
Long-Distance Regulation of Fetal Vδ Gene Segment TRDV4 by the Tcrd Enhancer (2011) (22)
HLA-A2 mutants immunoselected in vitro. Definition of residues contributing to an HLA-A2-specific serological determinant (1983) (22)
Developmental Activation of the TCR α Enhancer Requires Functional Collaboration among Proteins Bound Inside and Outside the Core Enhancer1 (2004) (22)
Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci (2018) (21)
Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire. (2017) (21)
Developmental regulation of V(D)J recombination at the TCR alpha/delta locus. (1998) (20)
Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes (2018) (20)
A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. (1999) (19)
Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2. (1984) (18)
Regulation of TCRβ Allelic Exclusion by Gene Segment Proximity and Accessibility (2011) (18)
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus (2021) (18)
Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. (2007) (17)
KAP-1 Promotes Resection of Broken DNA Ends Not Protected by γ-H2AX and 53BP1 in G1-Phase Lymphocytes (2014) (16)
Allele-specific regulation of TCR beta variable gene segment chromatin structure. (2005) (15)
Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain. (1982) (14)
Structure and Function of the Glycosaminoglycan Binding Site of Chemokine Macrophage-Inflammatory Protein-1β (1999) (14)
Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line. (1990) (13)
T-cell receptor α enhancer is inactivated in αβ T lymphocytes (2015) (13)
Specification of Vδ and Vα Usage by Tcra/Tcrd Locus V Gene Segment Promoters (2015) (12)
An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments (2016) (11)
A Role for MAPK in Feedback Inhibition of Tcrb Recombination1 (2006) (9)
A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra–Tcrd locus (2020) (9)
Regulation of chromatin accessibility for V(D)J recombination. (1999) (8)
Expression of human T cell receptor-gamma delta structural forms. (1989) (8)
severe combined immunodeficiency caused by complete deficiency of the CD 3 subunit of the T-cell antigen receptor complex (2007) (7)
Diversification of the TCR β Locus Vβ Repertoire by CTCF (2018) (6)
Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus. (2001) (5)
Developmental Regulation of VDJ Recombination By the Core Fragment of the T Cell Receptor (cid:97) Enhancer (1996) (4)
Transcriptional Regulation of the Human T Cell Receptor δ Gene (1995) (3)
CHAPTER 8 – Allelic Exclusion, Isotypic Exclusion, and the Developmental Regulation of V(D)J Recombination (2003) (3)
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire (2021) (3)
Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates (2015) (3)
Flanking nuclear matrix attachment regions synergize with the T cell receptor d enhancer to promote V ( D ) (1999) (2)
ALLERGY AND OTHER HYPERSENSITIVITIES (2013) (2)
Locus β the Murine TCR between Active and Inactive Chromatin at A Barrier-Type Insulator Forms a Boundary (2011) (2)
Regulation of Tcra gene assembly by a complex hierarchy of germline J α promoters (2008) (2)
Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498. (2017) (2)
Regulation of T Cell Receptor (cid:100) Gene Rearrangement by CBF/PEBP2 By (1997) (2)
T 3 glycoprotein is functional although structurally distinct on human T-cell receptor y T lymphocytes ( activation / antigen receptor / glycosylation / intracellular calcium / phosphorylation ) (1)
Immunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an MHC independent human alpha/beta T cell receptor. (1994) (1)
Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149. (2016) (1)
Immunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an mhc independent human α/β T cell receptor (1994) (1)
Some nuts are tougher to crack than others. (2006) (1)
Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements. (2016) (1)
The Ties that Bind (the Igh Locus). (2016) (1)
Gene Segment Chromatin Structure Variable β Allele-Specific Regulation of TCR (2005) (0)
Human T cell receptor gamma delta structure. (1989) (0)
Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers (1992) (0)
A CTCF-dependent regulatory element in the mouse TCRα/δ locus shapes the TCRα/δ repertoire (HEM2P.233) (2015) (0)
Promoter-Distal Elements and B Cells by Evolutionarily Conserved CD69 Gene Is Differentially Regulated in T (2009) (0)
Development 14i NKT Cell α Rearrangement Impact V α Multiple Constraints at the Level of TCR (2013) (0)
Transcriptional regulation of the human T cell receptor delta gene. (1995) (0)
Allelic Exclusion b Associated with TCR Chromatin b A Change in the Structure of V (0)
Locus V Gene Segment Promoters Tcra/Tcrd Usage by α and V δ Specification of V (2014) (0)
Kinase and NFAT Line : Roles of Extracellular Signal-Regulated Receptor Activation in a Human Mast Cell Chemokine Production by G Protein-Coupled and (2000) (0)
Specification Of Va And Vd Usage By Tcra/tcrd Locus V Gene Segment Promoters (2014) (0)
Mechanisms that diversify an otherwise intrinsically processive Trav-Traj recombination program (2017) (0)
(T cells/cytokine superfamily/chemotaxis/monocyte/cytoplasmic free calcium) (2016) (0)
ImmunoHorizons, a New Home for Immunology Research (2017) (0)
Abstracts of the First Biennial Symposium on Regulatory T Cells and T Helper Cells. March 30, 2012. London, United Kingdom. (2012) (0)
Regulation of T Cell Receptor 8 Gene Rearrangement by c-Myb By (1996) (0)
Immunology at Duke: 2011 (2011) (0)
RSSs set the odds for exclusion (2020) (0)
Segments In Vivo Nucleosomes at Accessible TCR Gene Transcription-Dependent Mobilization of (2010) (0)
On the Horizon (2018) (0)
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus (2021) (0)
Methods for Study of Mouse T Cell Receptor α and β Gene Rearrangements. (2023) (0)
Enhancer Tcrd Segment TRDV4 by the Gene d Long-Distance Regulation of Fetal V (0)
Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer (1991) (0)
Chromatin conformations and contacts that support Tcra/d locus rearrangement (62.2) (2011) (0)
The T cell receptor alpha/delta locus adopts distinct contracted conformations during primary and secondary T cell receptor α rearrangement (HEM2P.242) (2015) (0)
Severe Combined Immunodeficiency Caused by Complete Deficiency of the CD 3 ζ Subunit of the T Cell Antigen Receptor Complex Running Title : Human SCID Due to Complete CD 3 ζ Deficiency (2006) (0)
Evidence for controlled gene rearrangements and cytokine production during development of human TCR gamma delta+ lymphocytes. (1991) (0)

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