Michael Samuel Neuberger

Michael Samuel Neuberger's AcademicInfluence.com Rankings

Biology

#8678

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#11793

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Computational Biology

#166

World Rank

#167

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Genetics

#869

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#964

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Molecular Biology

#1122

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#1147

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Biology

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Michael Samuel Neuberger's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mutational Processes Molding the Genomes of 21 Breast Cancers (2012) (1622)
Replacing the complementarity-determining regions in a human antibody with those from a mouse (1986) (1333)
Molecular mechanisms of antibody somatic hypermutation. (2007) (1002)
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification (2002) (933)
DNA Deamination Mediates Innate Immunity to Retroviral Infection (2003) (883)
Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice (2002) (745)
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies (1987) (633)
B cells acquire antigen from target cells after synapse formation (2001) (628)
Hyperresponsive B Cells in CD22-Deficient Mice (1996) (556)
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. (2002) (540)
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase (2002) (539)
The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G (2003) (501)
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. (2005) (499)
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. (1998) (476)
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. (2004) (473)
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region (1994) (398)
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. (1998) (384)
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. (1983) (342)
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. (2004) (326)
Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies (1999) (326)
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis (2013) (312)
The B-cell antigen receptor of the five immunoglobulin classes (1991) (295)
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. (1993) (281)
A hapten-specific chimaeric IgE antibody with human physiological effector function (1985) (280)
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. (1998) (268)
DNA Deamination Mediates Innate Immunity to Retroviral Infection (2004) (263)
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. (1998) (261)
Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies (2000) (249)
Recombinant antibodies possessing novel effector functions (1984) (246)
Immunity through DNA deamination. (2003) (240)
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. (1993) (236)
Developmental regulation of IgM secretion: The role of the carboxy-terminal cysteine (1990) (235)
AID Is Essential for Immunoglobulin V Gene Conversion in a Cultured B Cell Line (2002) (231)
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class‐switch recombination: parallels with somatic hypermutation (1999) (229)
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation (2001) (228)
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus (1990) (227)
Somatic hypermutation of immunoglobulin genes. (1996) (225)
Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence (1985) (220)
Activation of mouse complement by monoclonal mouse antibodies (1981) (219)
Targeting of non-lg sequences in place of the V segment by somatic hyper mutation (1995) (213)
The immunoglobulin kappa locus contains a second, stronger B‐cell‐specific enhancer which is located downstream of the constant region. (1989) (200)
B cells extract and present immobilized antigen: implications for affinity discrimination (2000) (199)
Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities (2005) (190)
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 −/− ung −/− mice (2006) (186)
Codon bias targets mutation (1995) (175)
Both DNA strands of antibody genes are hypermutation targets. (1998) (174)
The immunogenicity of chimeric antibodies (1989) (174)
Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro (2000) (167)
Association of CD22 with the B cell antigen receptor (1993) (165)
DNA deamination in immunity: AID in the context of its APOBEC relatives. (2007) (159)
Expression and targeting of intracellular antibodies in mammalian cells. (1990) (154)
Maturation of the immune response. (1996) (149)
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination (2001) (145)
The mouse IgH 3′‐enhancer (1991) (145)
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. (2008) (144)
Mice carrying a CD20 gene disruption (1998) (141)
In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)* (2003) (141)
Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation (2005) (140)
A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. (1989) (139)
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. (1997) (136)
Monitoring and interpreting the intrinsic features of somatic hypermutation (1998) (132)
Mice Deficient in APOBEC2 and APOBEC3 (2005) (129)
Polymeric immunoglobulin M is secreted by transfectants of non‐lymphoid cells in the absence of immunoglobulin J chain. (1987) (128)
Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo (2008) (127)
Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers (1997) (120)
Acceleration of intracellular targeting of antigen by the B‐cell antigen receptor: importance depends on the nature of the antigen–antibody interaction (1997) (119)
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes. (1991) (119)
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. (1995) (119)
Interaction of CD22 with α2,6‐linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity? (2002) (113)
Antibody diversification by somatic mutation: from Burnet onwards (2008) (110)
Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy (2009) (106)
Regulation of membrane IgM expression in secretory B cells: translational and post‐translational events. (1987) (106)
Membrane location of a deoxyribonuclease implicated in the genetic transformation of Diplococcus pneumoniae (1975) (100)
Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity (2000) (99)
SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair (2006) (99)
The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface (1990) (99)
Antigen presentation by the B cell antigen receptor is driven by the α β sheath and occurs independently of its cytoplasmic tyrosines (1993) (94)
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence (2009) (94)
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice (2012) (91)
Strategies for expressing human antibody repertoires in transgenic mice. (1996) (91)
Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID (2010) (90)
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines (2002) (90)
Identification of a deoxyribonuclease implicated in genetic transformation of Diplococcus pneumoniae (1975) (90)
The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment. (1994) (86)
Antigen Receptor Signaling Gives Lymphocytes a Long Life (1997) (85)
Memory in the B-cell compartment: antibody affinity maturation. (2000) (84)
DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses (2003) (83)
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deamination (2004) (82)
Cd22a PRE-mRNA Dysregulated Expression of the Cd22 Gene as a Result of a Short Interspersed Nucleotide Element Insertion in Cd22a Lupus-Prone Mice1 (2000) (81)
Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. (1994) (77)
Erratum: DNA Deamination Mediates Innate Immunity to Retroviral Infection (Cell (June 13, 2003) 113 (803-809)) (2004) (75)
Role of a deoxyribonuclease in the genetic transformation of Diplococcus pneumoniae. (1974) (74)
AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity (2009) (74)
Dependence of antibody gene diversification on uracil excision (2007) (74)
The Immunoglobulin (Ig)α and Igβ Cytoplasmic Domains Are Independently Sufficient to Signal B Cell Maturation and Activation in Transgenic Mice (1997) (70)
REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase (2011) (69)
The intron requirement for immunoglobulin gene expression is dependent upon the promoter. (1988) (68)
Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T (2007) (67)
The importance of the 3′-enhancer region in immunoglobulinxgene expression (1990) (67)
High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH Region (2013) (65)
The targeting of somatic hypermutation. (1996) (65)
Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line. (1981) (63)
The AKV Murine Leukemia Virus Is Restricted and Hypermutated by Mouse APOBEC3 (2009) (62)
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line (2000) (60)
Interactions Between Glycine Decarboxylase, the Tricarboxylic Acid Cycle and the Respiratory Chain in Pea Leaf Mitochondria (1985) (58)
Antibody Repertoires of Four- and Five-Feature Translocus Mice Carrying Human Immunoglobulin Heavy Chain and κ and λ Light Chain Yeast Artificial Chromosomes (1999) (57)
Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A) (2011) (56)
Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain (1998) (55)
Reciprocal chromosome translocation between c-myc and immunoglobulin γ2b genes (1983) (54)
Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (1989) (54)
Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1 (2008) (53)
The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. (1988) (53)
Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D). (1996) (51)
MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. (2006) (49)
Somatic hypermutation. (1995) (47)
The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age. (2000) (47)
Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation (2014) (45)
The diversity of antigen‐specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci (1994) (44)
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants. (2008) (41)
Insights into DNA deaminases (2007) (41)
Creation of Mice Expressing Human Antibody Light Chains by Introduction of a Yeast Artificial Chromosome Containing the Core Region of the Human Immunoglobulin κ Locus (1993) (41)
CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31 (2011) (41)
Production of antibody-tagged enzymes by myeloma cells: application to DNA polymerase I Klenow fragment. (1986) (40)
Epstein-Barr Virus and the Somatic Hypermutation of Immunoglobulin Genes in Burkitt's Lymphoma Cells (2001) (36)
Somatic hypermutation of immunoglobulin κ transgenes: Association of mutability with demethylation (2001) (34)
Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid‐specific expression in transgenic mice (1987) (34)
Lack of somatic mutation in a χ light chain transgene (1990) (32)
Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes. (1989) (32)
The Mouse B‐Cell Antigen Receptor: Definition and Assembly of the Core Receptor of the Five Immunoglobulin Isotypes (1993) (31)
Molecular genetics of immunoglobulin (1987) (29)
The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin (2010) (29)
Novartis Medal Lecture. Antibodies: a paradigm for the evolution of molecular recognition. (2002) (29)
Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes. (1999) (29)
Antibodies generated from human immunoglobulin miniloci in transgenic mice. (1994) (28)
Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones. (1996) (28)
Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines. (1993) (26)
Purification and properties of Klebsiella aerogenes D-arabitol dehydrogenase. (1979) (26)
Purification and properties of D-ribulokinase and D-xylulokinase from Klebsiella aerogenes. (1981) (26)
Making novel antibodies by expressing transfected immunoglobulin genes (1985) (24)
By‐products of immunoglobulin somatic hypermutation (2003) (23)
Production of Antigen-Specific Human Monoclonal Antibodies: Comparison of Mice Carrying IgH/κ or IgH/κ/λ Transloci (2002) (21)
Chromosome translocation activates heterogeneously initiated, bipolar transcription of a mouse c‐myc gene. (1985) (20)
Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci. (2011) (20)
In vivo and in vitro studies of immunoglobulin gene somatic hypermutation. (2001) (20)
The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification (2011) (19)
Mice perform a human repertoire (1997) (18)
Generating high-avidity human Mabs in mice (1996) (17)
The cytoplasmic AID complex. (2012) (17)
RNA Editing AIDs Antibody Diversification? (2000) (16)
Structure of an experimentally evolved gene duplication encoding ribitol dehydrogenase in a mutant of Klebsiella aerogenes. (1981) (16)
The importance of the 3'-enhancer region in immunoglobulin kappa gene expression. (1990) (16)
Membrane immunoglobulin without sheath or anchor. (1993) (16)
Construction of novel antibodies by use of DNA transfection: design of plasmid vectors (1986) (16)
Antibody diversification and selection in the mature B-cell compartment. (1999) (16)
Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage. (1995) (15)
Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice (2013) (14)
Novel antibodies by DNA manipulation. (1988) (13)
The lgk 3'-enhancer triggers gene expression in early B lymphocytes but its activity in enhanced on B cell activation (1996) (12)
Investigations into the Klebsiella aerogenes pentitol operons using specialised transducing phages λprbt and λprbtdal (1979) (11)
Philosophical Transactions of the Royal Society B: Biological Sciences - Preface (2009) (11)
Production of antigen-specific human monoclonal antibodies: comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci. (2002) (10)
19 – Protein Engineering of Antibody Molecules (1973) (10)
Lymphoid-specific transcriptional activation by components of the IgH enhancer: studies on the E2/E3 and octanucleotide elements. (1990) (8)
Generation of antibody repertoires in transgenic mice (1991) (8)
Reciprocal chromosome translocation between c-myc and immunoglobulin gamma 2b genes. (1983) (6)
Immunoglobulin Gene Expression (1988) (6)
Germline ablation of SMUG 1 DNA glycosylase causes loss of 5-hydroxymethyluracil-and UNG-backup uracil-excision activities and increases cancer predisposition of Ung / Msh 2 / mice (2012) (6)
Lack of somatic mutation in a kappa light chain transgene. (1990) (6)
Isotype exclusion and transgene down-regulation in immunoglobulin-lambda transgenic mice. (1989) (6)
Monoclonal antibodies. Mice perform a human repertoire. (1997) (5)
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α (2013) (5)
Immunology. RNA editing AIDs antibody diversification? (2000) (5)
Diversification and selection mechanisms for the production of protein repertoires (2000) (4)
Investigations into the Klebsiella aerogenes pentitol operons using specialised transducing phages lambdaprbt and lambdaprbt dal. (1979) (4)
Sequence of a secondary phage lambda attachment site located between the pentitol operons of Klebsiella aerogenes. (1981) (3)
A high-throughput assay for DNA deaminases. (2011) (3)
The expression of immunoglobulin genes. (1988) (2)
Author response: DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis (2013) (2)
César Milstein CH. 8 October 1927 – 24 March 2002 (2005) (2)
Construction, function and immunogenicity of recombinant monoclonal antibodies. (1990) (2)
Novel Antibodies by DNA Transfection (1986) (1)
Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103. (2015) (1)
Correction: High Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH Region (2013) (1)
The mechanism of somatic hypermutation at A·T pairs remains an open question (2005) (1)
Minicircular ColE1-related DNA in strains of Klebsiella aerogenes selected for fast growth on xylitol. (1980) (1)
Philosopical transactions of the royal society: Preface (2001) (0)
Chapter 6 Immunoglobulin gene expression (1987) (0)
Structural of delta 1-76 CTNNBL1 in space group I222 (2013) (0)
Transducing phages for analysis of gene duplications (1978) (0)
Structure of full-length CTNNBL1 in P43212 space group (2013) (0)
Both DNA strands of antibody gi (0)
The Ig kappa 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation. (1996) (0)
Improvements in stimulation medium range. (1990) (0)
Restructuring Enzymes and Antibodies (1985) (0)
Wartime discoveries on amino acids: functions in protein structure and as a dietary nitrogen source (2012) (0)
Germline Human IgH/Ig Naturally in Ig-Knockout Rats Carrying High-Affinity IgG Antibodies Develop (2013) (0)
The generation of diversity in antibody genes (2007) (0)
Peer review correspondence (2013) (0)
The IgK 3 -enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation (2005) (0)
Crystallographic and solution studies of H-protein from the glycine decarboxylase complex in pea mitochondria (1993) (0)
Cookery in cloning (1985) (0)
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 356 (1405) (2001) (0)
Lupus-Prone Mice a Cd22 Interspersed Nucleotide Element Insertion in Gene as a Result of a Short Cd22 of the PRE-mRNA Dysregulated Expression a Cd22 (2000) (0)
Abstract 611: AID/APOBEC cytidine deaminases can mimic the phenomenon of localized hypermutation in cancer orkataegis. (2013) (0)
Specific Properties of Higher Plant Mitochondria (1985) (0)
Dysregulated Expression of theCd22Gene as a Result of a Short Interspersed Nucleotide Element Insertion inCd22 Lupus-Prone Mice (2000) (0)
Antibody gene diversification by somatic hypermutation (2001) (0)
Regulation of somatic hypermutation (1997) (0)

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What Schools Are Affiliated With Michael Samuel Neuberger?

Michael Samuel Neuberger is affiliated with the following schools:

University College London

Michael Samuel Neuberger's Academic­Influence.com Rankings

Why Is Michael Samuel Neuberger Influential?

Michael Samuel Neuberger's Published Works

Published Works

What Schools Are Affiliated With Michael Samuel Neuberger?

Michael Samuel Neuberger's AcademicInfluence.com Rankings