Michael Antonio Savageau

Michael Antonio Savageau's AcademicInfluence.com Rankings

Biology

#4706

World Rank

#6995

Historical Rank

#1716

USA Rank

Biochemistry

#1025

World Rank

#1138

Historical Rank

#252

USA Rank

biology Degrees

Download Badge

Biology

Michael Antonio Savageau's Degrees

PhD Biochemistry University of California, Davis
Bachelors Biochemistry University of California, Davis

Why Is Michael Antonio Savageau Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Michael A. Savageau is a Distinguished Professor in the Departments of Microbiology & Molecular Genetics and Biomedical Engineering at The University of California, Davis. He was named Fellow of the Institute of Electrical and Electronics Engineers in 2013 for application of systems engineering concepts to molecular biology.

(See a Problem?)

Michael Antonio Savageau's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions. (1969) (741)
Development of Genetic Circuitry Exhibiting Toggle Switch or Oscillatory Behavior in Escherichia coli (2003) (713)
Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology (1976) (498)
Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation. (1969) (471)
Escherichia coli Habitats, Cell Types, and Molecular Mechanisms of Gene Control (1983) (327)
Recasting nonlinear differential equations as S-systems: a canonical nonlinear form (1987) (306)
Generalized indicator plate for genetic, metabolic, and taxonomic studies with microorganisms (1977) (238)
Design of gene circuits: lessons from bacteria (2004) (230)
Biochemical systems analysis. 3. Dynamic solutions using a power-law approximation. (1970) (224)
Comparison of classical and autogenous systems of regulation in inducible operons (1974) (218)
Design principles for elementary gene circuits: Elements, methods, and examples. (2001) (198)
Michaelis-Menten mechanism reconsidered: implications of fractal kinetics. (1995) (158)
Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences (1987) (123)
Concepts relating the behavior of biochemical systems to their underlying molecular properties. (1971) (122)
Rules for coupled expression of regulator and effector genes in inducible circuits. (1996) (122)
Accuracy of alternative representations for integrated biochemical systems. (1987) (120)
Duplication Frequency in a Population of Salmonella enterica Rapidly Approaches Steady State With or Without Recombination (2010) (116)
Design of molecular control mechanisms and the demand for gene expression. (1977) (112)
Molecular mechanisms of multiple toxin–antitoxin systems are coordinated to govern the persister phenotype (2013) (111)
Glutamate dehydrogenase from Escherichia coli: purification and properties (1975) (111)
Comparative analysis of prototype two‐component systems with either bifunctional or monofunctional sensors: differences in molecular structure and physiological function (2003) (106)
The tricarboxylic acid cycle in Dictyostelium discoideum. I. Formulation of alternative kinetic representations. (1992) (91)
Development of fractal kinetic theory for enzyme-catalysed reactions and implications for the design of biochemical pathways. (1998) (89)
Growth of complex systems can be related to the properties of their underlying determinants. (1979) (87)
Biochemical systems theory and metabolic control theory: 2. the role of summation and connectivity relationships (1987) (85)
Demand theory of gene regulation. I. Quantitative development of the theory. (1998) (83)
Phenotypes and tolerances in the design space of biochemical systems (2009) (82)
Growth equations: A general equation and a survey of special cases (1980) (80)
Allometric morphogenesis of complex systems: Derivation of the basic equations from first principles. (1979) (76)
Network regulation of the immune response: alternative control points for suppressor modulation of effector lymphocytes. (1985) (75)
Introduction to S-systems and the underlying power-law formalism (1988) (75)
Extending the method of mathematically controlled comparison to include numerical comparisons (2000) (74)
Effects of alternative connectivity on behavior of randomly constructed Boolean networks (2002) (74)
A comparison of variant theories of intact biochemical systems. I. Enzyme-enzyme interactions and biochemical systems theory. (1989) (72)
Strategies for representing metabolic pathways within biochemical systems theory: reversible pathways. (1989) (70)
Application of Biochemical Systems Theory to Metabolism in Human Red Blood Cells (1996) (69)
Systemic properties of ensembles of metabolic networks: application of graphical and statistical methods to simple unbranched pathways (2000) (68)
Relative Amino Acid Composition Signatures of Organisms and Environments (2013) (67)
Constraints among molecular and systemic properties: implications for physiological genetics. (1989) (67)
Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells. (1996) (66)
Power-Law Approach to Modeling Biological Systems : I. Theory (1982) (65)
Demand theory of gene regulation. II. Quantitative application to the lactose and maltose operons of Escherichia coli. (1998) (62)
The tricarboxylic acid cycle in Dictyostelium discoideum. II. Evaluation of model consistency and robustness. (1992) (61)
Genetic regulatory mechanisms and the ecological niche of Escherichia coli. (1974) (60)
Design principles for regulator gene expression in a repressible gene circuit. (2003) (60)
A comparison of variant theories of intact biochemical systems. II. Flux-oriented and metabolic control theories. (1989) (57)
Rules for the evolution of gene circuitry. (1998) (53)
Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. (2007) (50)
Signalling network with a bistable hysteretic switch controls developmental activation of the σF transcription factor in Bacillus subtilis (2006) (50)
Comparing systemic properties of ensembles of biological networks by graphical and statistical methods (2000) (49)
The tricarboxylic acid cycle in Dictyostelium discoideum. III. Analysis of steady state and dynamic behavior. (1992) (49)
Biochemical systems theory: operational differences among variant representations and their significance. (1991) (49)
Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes (2003) (49)
Effect of overall feedback inhibition in unbranched biosynthetic pathways. (2000) (49)
Optimal design of feedback control by inhibition: dynamic considerations. (1975) (48)
Equivalence between S-systems and Volterra systems (1986) (48)
Proofreading systems of multiple stages for improved accuracy of biological discrimination. (1980) (46)
Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. (2002) (46)
Power-Low Approach to Modeling Biological Systems : II. Application to Ethanol Production (1982) (45)
Subunit structure of regulator proteins influences the design of gene circuitry: analysis of perfectly coupled and completely uncoupled circuits. (1995) (44)
Energy cost of proofreading to increase fidelity of transfer ribonucleic acid aminoacylation. (1979) (44)
A Suprasystem of Probability Distributions (1982) (44)
Dominance according to metabolic control analysis: major achievement or house of cards? (1992) (43)
A theory of alternative designs for biochemical control systems. (1985) (42)
Network regulation of the immune response: modulation of suppressor lymphocytes by alternative signals including contrasuppression. (1985) (42)
Molecular Mechanisms Driving Switch Behavior in Xylem Cell Differentiation. (2019) (42)
The tricarboxylic acid cycle in Dictyostelium discoideum. IV. Resolution of discrepancies between alternative methods of analysis. (1992) (39)
Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes (2005) (38)
Completely uncoupled and perfectly coupled gene expression in repressible systems. (1997) (38)
Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli. (2010) (38)
Optimal design of feedback control by inhibition (1974) (36)
The tricarboxylic acid cycle in Dictyostelium discoideum. Systemic effects of including protein turnover in the current model. (1993) (34)
Regulation of differentiated cell-specific functions. (1983) (34)
Power-law formalism: a canonical nonlinear approach to modeling and analysis (1995) (34)
Quantifying Global Tolerance of Biochemical Systems: Design Implications for Moiety-Transfer Cycles (2009) (33)
Analytical Solutions to a Generalized Growth Equation (1984) (32)
On the evolution of accuracy and cost of proofreading tRNA aminoacylation. (1979) (31)
Optimal design of feedback control by inhibition (1975) (30)
Chapter 5 Enzyme kinetics in vitro and in vivo: Michaelis-Menten revisited (1995) (30)
Automated construction and analysis of the design space for biochemical systems (2010) (30)
Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems (1975) (29)
Qualitatively distinct phenotypes in the design space of biochemical systems (2009) (28)
Feedfoward inhibition in biosynthetic pathways: inhibition of the aminoacyl-tRNA synthetase by intermediates of the pathway. (1979) (28)
Proteins of Escherichia coli come in sizes that are multiples of 14 kDa: domain concepts and evolutionary implications. (1986) (28)
In vitro studies of beating heart cells in culture. XII. The utilization of ATP and phosphocreatine in oligomycin and 2-deoxyglucose inhibited cells. (1969) (26)
Evolution of enzymes in a series is driven by dissimilar functional demands (2006) (26)
Application of the Combined Nonlinear-Condensation Transformation to Problems in Statistical Analysis and Theoretical Physics (2003) (25)
Transcription Factors in Escherichia coli Prefer the Holo Conformation (2013) (25)
A bistable hysteretic switch in an activator–repressor regulated restriction–modification system (2013) (24)
Strategy Revealing Phenotypic Differences among Synthetic Oscillator Designs (2014) (23)
Influence of fractal kinetics on molecular recognition (1993) (23)
Design of the lac gene circuit revisited. (2011) (23)
Relating Mutant Genotype to Phenotype via Quantitative Behavior of the NADPH Redox Cycle in Human Erythrocytes (2010) (21)
Integrated function of a kinetic proofreading mechanism: steady-state analysis testing internal consistency of data obtained in vivo and in vitro and predicting parameter values. (1984) (21)
Optimization of kinetic proofreading: a general method for derivation of the constraint relations and an exploration of a specific case. (1981) (21)
Quantitative Biology: Theory, Computational Methods, and Models (2018) (21)
Finding multiple roots of nonlinear algebraic equations using S-system methodology (1993) (20)
Autogenous and Classical Regulation of Gene Expression: A General Theory and Experimental Evidence (1979) (20)
Regulatory Design Governing Progression of Population Growth Phases in Bacteria (2012) (19)
Control of metabolism: where is the theory? (1987) (19)
Phenotypic deconstruction of gene circuitry. (2013) (18)
Irreversibility in unbranched pathways: preferred positions based on regulatory considerations. (2001) (18)
Elucidating the genotype–phenotype map by automatic enumeration and analysis of the phenotypic repertoire (2015) (17)
Optimal conditions for palmitate oxidation by rat heart homogenates. (1968) (17)
Unrelated toxin–antitoxin systems cooperate to induce persistence (2015) (17)
A possible role in the regulation of primary animation for a complex of glutamine: -ketoglutarate amidotransferase and glutamate dehydrogenase in Escherichia coli. (1972) (17)
Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems (2016) (16)
Models of Gene Function: General Methods of Kinetic Analysis and Specific Ecological Correlates (1983) (14)
Reconstructionist molecular biology. (1991) (14)
Mathematics of organizationally complex systems. (1985) (14)
Statistical significance of partial base-pairing potential: implications for recombination of SV40 DNA in eukaryotic cells. (1983) (12)
Accuracy of proofreading with zero energy cost. (1981) (12)
The challenge of reconstruction. (1991) (12)
Metabolite channeling: implications for regulation of metabolism and for quantitative description of reactions in vivo. (1991) (12)
Identification and characterization of the cAMP binding proteins of yeast by photoaffinity labeling. (1979) (12)
Some properties of the Lerch family of discrete distributions (2005) (11)
Design of gene circuitry by natural selection: analysis of the lactose catabolic system in Escherichia coli. (1999) (10)
Implementation of the Combined--Nonlinear Condensation Transformation (2002) (10)
Phenotype-centric modeling for elucidation of biological design principles. (2018) (10)
Biomedical Engineering Strategies in System Design Space (2011) (10)
Biochemical Systems Theory: Alternative Views of Metabolic Control (1990) (10)
Integrated function of a kinetic proofreading mechanism: dynamic analysis separating the effects of speed and substrate competition on accuracy. (1984) (10)
A comparison of the monomial method and the S-system method for solving systems of algebraic equations (1998) (9)
Feedforward inhibition in biosynthetic pathways: inhibition of the aminoacyl-tRNA synthetase by the penultimate product. (1979) (9)
Design principles of a conditional futile cycle exploited for regulation. (2015) (9)
Phenotypes and Design Principles in System Design Space (2013) (8)
Method for determining natural design principles of biological control circuits (1998) (8)
Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems (2016) (7)
Integrated function of a kinetic proofreading mechanism: double-stage proofreading by isoleucyl-tRNA synthetase. (1986) (7)
Mechanistic Modeling of Biochemical Systems without A Priori Parameter Values Using the Design Space Toolbox v.3.0 (2020) (7)
Gene density over the chromosome of Escherichia coli: frequency distribution, spatial clustering, and symmetry (1985) (6)
S-System Analysis of Biological Systems (1985) (5)
The Tricarboxylic Acid Cycle inDictyostelium discoideum—Two Methods of Analysis Applied to the Same Model☆ (1996) (5)
Molecular Mechanisms Driving Bistable Switch Behavior in Xylem Cell Differentiation (2019) (4)
Repression of the threonine synthetase system in Escherichia coli. (1970) (4)
Deconstructing Complex Nonlinear Models in System Design Space (2014) (4)
Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks (2007) (3)
RNA splicing: advantages of parallel processing. (1982) (3)
Inhibition of growth by imadazol(on)e propionic acid: Evidence in vivo for coordination of histidine catabolism with the catabolism of other amino acids (1979) (3)
Contraction rate of rat cardiac cells in culture: responses to prolonged perfusion. (1967) (3)
Molecular Systems Predict Equilibrium Distributions of Phenotype Diversity Available for Selection (2021) (2)
Gene regulation models and evolution (2009) (2)
System Design Principles (2012) (2)
Parameter Estimation and Random Number Generation from a Zipf-Related Lerch Distribution (2002) (2)
Book Review:Energetics and Kinetics in Biotechnology. J. A. Roels (1984) (2)
Local cause of coherence in Boolean networks (2006) (2)
Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory (1994) (2)
TaxisPy: A Python-based software for the quantitative analysis of bacterial chemotaxis. (2020) (2)
Convergence Acceleration Techniques (2002) (1)
Statistical Properties of Randomly Constructed Boolean Networks that Resemble the Transcription Factor Network of Escherichia coli (2002) (1)
Cardiac Cells in a Capillary Tube (1973) (1)
Statistical inference and modeling with the S distribution (2001) (1)
Biochemical Systems Theory Applied To The Human Red-blood Cell (1991) (1)
Stabilizing and Destabilizing Effects of Embedding 3-Node Subgraphs on the State Space of Boolean Networks (2008) (1)
Evolution of a Genome-Encoded Bias in Amino Acid Biosynthetic Pathways Is a Potential Indicator of Amino Acid Dynamics in the Environment (2014) (1)
A mathematical model of the contraction rate of myocardial cells. (1968) (1)
TaxisPy: A Python-based Software for the Quantitative Analysis of Bacterial Chemotaxis (2020) (1)
In: T.B.L. Kirkwood, R.F. Rosenberger and D.J. Galas, Editors, , Chapman and Hall, Berlin (1986). (1989) (0)
NONLINEAR CIRCUITS OF GENE REGULATION AND THEIR ANALYSIS AS SYNERGISTIC SYSTEMS. (1984) (0)
The seventh Bellman Prize. (1999) (0)
Inhibition of Growth by Imidazol(on)e Propionic Acid: Evidence in vivo for Coordination of Histidine Catabolism of Other Amino Acids with the Catabolism (1979) (0)
A POSSIBLE ROLE IN THE REGULATION OF PRIMARY AMINATION FOR OF GLUTAMINE : c + KETOGLUl ' ARATE AMIDOTRANSFERASE AND GLUTAMATE DEBYDROGENASE IN ESCHERICHIA COLI A COMPLEX (2003) (0)
Phenotype-Centric Modeling for Rational Metabolic Engineering (2021) (0)
R U L E S F OR T HE E V OL U T ION OF GE N E C IR C U IT R Y (1997) (0)
Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants (2011) (0)
Function, design and evolution of elementary gene circuits (2000) (0)
Temporal relations for analog simulations of asynchronous contraction of heart chambers. (1967) (0)
Biochemical Systems Theory With Applications To Metabolic Control (1990) (0)
2 6 N ov 2 00 6 Local cause of coherence in Boolean networks (2006) (0)
Contribution of Calcium Waves to the Regulation of Beating Rhythm in Sinoatrial Node Cells (2012) (0)
Final Report, December, 1999. Sloan - US Department of Energy joint postdoctoral fellowship in computational molecular biology [Canonical nonlinear methods for modeling and analyzing gene circuits and spatial variations during pattern formation in embryonic development] (1999) (0)
Optimal conditions for palmitate oxidation by rat heart homogenates. UCLA-12-686. (1968) (0)
Regulation of differentiated cell-specific functions ( switching of regulatory mechanism / positive vs . negative control / yeast mating type / bacteriophage A / Escherichia coli ) (0)
Growth Rate Effects on Global Regulation of E . coli Oxygen Sensing (0)
Book reviews (1989) (0)
Phenotype-centric modeling for rational metabolic engineering. (2022) (0)
Selection and Computational Potential of Gene Control Elements and Their Circuitry (2001) (0)
Correction: Transcription Factors in Escherichia coli Prefer the Holo Conformation (2013) (0)
eb 2 00 2 Convergence Acceleration Techniques (2002) (0)
toxin-antitoxin systems cooperate to induce persistence. (2015) (0)
Ssessing the Academic Work Environment for Women Scientists (2002) (0)
Phenotypic Differences Among Seven Synthetic Oscillator D esigns (2014) (0)
Erratum: "Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems" (Nature (1971) 229 (542)) (1971) (0)

This paper list is powered by the following services:

Other Resources About Michael Antonio Savageau

en.wikipedia.org

What Schools Are Affiliated With Michael Antonio Savageau?

Michael Antonio Savageau is affiliated with the following schools:

Michael Antonio Savageau's Academic­Influence.com Rankings