Michael Smith
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Canadian Nobel laureate in chemistry
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Chemistry
Michael Smith 's Degrees
- PhD Chemistry University of Oxford
- Bachelors Chemistry University of British Columbia
Why Is Michael Smith Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michael Smith was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry with Kary Mullis for his work in developing site-directed mutagenesis. Following a PhD in 1956 from the University of Manchester, he undertook postdoctoral research with Har Gobind Khorana at the British Columbia Research Council in Vancouver, British Columbia, Canada. Subsequently, Smith worked at the Fisheries Research Board of Canada Laboratory in Vancouver before being appointed a professor of biochemistry in the UBC Faculty of Medicine in 1966. Smith's career included roles as the founding director of the UBC Biotechnology Laboratory and the founding scientific leader of the Protein Engineering Network of Centres of Excellence . In 1996 he was named Peter Wall Distinguished Professor of Biotechnology. Subsequently, he became the founding director of the Genome Sequencing Centre at the BC Cancer Research Centre.
Michael Smith 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The nucleotide sequence of bacteriophage φX174 (1978) (539)
- Mutagenesis at a specific position in a DNA sequence. (1978) (441)
- A physical map of the mouse genome (2002) (338)
- Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding (1982) (280)
- The sequence of the DNAs coding for the mating-type loci of saccharomyces cerevisiae (1981) (254)
- Sequence of the gene for iso-l-cytochrome c in saccharomyces cerevisiae (1979) (247)
- Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. (1988) (184)
- The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence (1984) (181)
- A position effect in the control of transcription at yeast mating type loci (1981) (175)
- Nucleotide sequence of the yeast alcohol dehydrogenase II gene. (1983) (166)
- Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. (1989) (163)
- In vitro mutation analysis of the mating-type locus in yeast (1981) (162)
- Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region (1986) (135)
- Site-directed mutagenesis of cytochrome c shows that an invariant Phe is not essential for function (1985) (125)
- Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. (1981) (125)
- Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae (1991) (116)
- The isolation and nucleotide sequence of the complex AROM locus of Aspergillus nidulans. (1986) (114)
- Mutagenesis of Fujinami Sarcoma Virus: Evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity (1984) (112)
- Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis (1984) (103)
- Structure of the 3′ hairpin termini of four rodent parvovirus genomes: Nucleotide sequence homology at origins of DNA replication (1979) (100)
- Identification and isolation of the yeast cytochrome c gene (1978) (99)
- Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. (1980) (93)
- Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences. (1986) (92)
- Mutations of the yeast SUP4 tRNATyr Locus: Transcription of the mutant genes in vitro (1980) (86)
- ADR1-mediated regulation of ADH2 requires an inverted repeat sequence (1986) (84)
- Mutations at the yeast SUP4 tRNATyr locus: DNA sequence changes in mutants lacking suppressor activity (1980) (83)
- Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum oligodeoxyribonucleotide length (1979) (82)
- Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression (1983) (73)
- Saccharomyces cerevisiae CYC1 mRNA 5'-end positioning: analysis by in vitro mutagenesis, using synthetic duplexes with random mismatch base pairs (1985) (62)
- The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D. (1990) (57)
- THE EMPIRE FILTERS BACK: CONSUMPTION, PRODUCTION, AND THE POLITICS OF STARBUCKS COFFEE (1996) (55)
- Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor. (1997) (54)
- Isolation and characterization of the SPT2 gene, a negative regulator of Ty-controlled yeast gene expression (1985) (51)
- Domain structure and interaction within the pentafunctional arom polypeptide. (1991) (46)
- The base-pairing specificity of cellulose-pdT9. (1975) (46)
- Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper‐like coiled‐coil motifs. (1994) (46)
- Deletions and single base pair changes in the yeast mating type locus that prevent homothallic mating type conversions. (1983) (45)
- Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. (1979) (43)
- Site-specific mutagenesis using oligodeoxyribonucleotides: isolation of a phenotypically silent phi X174 mutant, with a specific nucleotide deletion, at very high efficiency. (1980) (42)
- Variation in the polyadenylylation site of bovine prolactin mRNA. (1982) (42)
- Nucleotide sequence of the 3′ terminal third of rabbit α-globin messenger RNA: Comparison with human α-globin messenger RNA (1977) (42)
- Homoeo-domain homology in yeast MATα2 is essential for repressor activity (1986) (42)
- Structure of the CAC1 Gene and in Situ Characterization of Its Expression (The Arabidopsis thaliana Gene Coding for the Biotin-Containing Subunit of the Plastidic Acetyl-Coenzyme A Carboxylase) (1997) (39)
- Expression in Escherichia coli of a synthetic gene coding for horse heart myoglobin. (1991) (38)
- Bioactive recombinant methionyl bovine prolactin: structure-function studies using site-specific mutagenesis. (1989) (38)
- The 3' terminal sequence of chicken ovalbumin messenger RNA and its comparison with other messenger RNA molecules. (1976) (36)
- Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens. (1979) (35)
- Intrachromosomal movement of genetically marked Saccharomyces cerevisiae transposons by gene conversion (1984) (34)
- Production of hydroxy fatty acids in the seeds of Arabidopsis thaliana. (2000) (33)
- Single amino acid substitutions in recombinant bovine prolactin that markedly reduce its mitogenic activity in Nb2 cell cultures. (1991) (29)
- The alcohol dehydrogenase genes of the yeast, Saccharomyces cerevisiae: isolation, structure, and regulation. (1982) (29)
- Synthetic DNA and Biology (Nobel Lecture) (1994) (27)
- Site-directed mutagenesis (1986) (27)
- Constructed Mutants Using Synthetic Oligodeoxyribonucleotides as Site-Specific Mutagens (1981) (27)
- Enzymatic synthesis of oligonucleotides of defined sequence: synthesis of a segment of yeast iso-1-cytochrome c gene. (1977) (24)
- Further studies on the properties of oligonucleotide cellulose columns. (1973) (23)
- Enzymatic synthesis of deoxyribo-oligonucleotides of defined sequence. Properties of the enzyme. (1974) (23)
- Sites and gene products involved in lambdoid phage DNA packaging (1993) (23)
- Selective overexpression of the QUTE gene encoding catabolic 3-dehydroquinase in multicopy transformants of Aspergillus nidulans. (1990) (23)
- Identification of an upstream repressor site controlling the expression of an anaerobic gene (ANB1) in Saccharomyces cerevisiae. (1989) (22)
- Enzymatic synthesis of oligodeoxyribonucleotides of defined sequence. (1978) (21)
- Sequence analysis of the phage 21 genes for prohead assembly and head completion. (1993) (21)
- Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation (1989) (20)
- Immunoglobulin‐like messenger RNA in a mouse T cell lymphoma (1977) (20)
- Gene K of bacteriophage phi X174 codes for a protein which affects the burst size of phage production (1985) (20)
- Analysis of disulphide bridge function in recombinant bovine prolactin using site-specific mutagenesis and renaturation under mild alkaline conditions: a crucial role for the central disulphide bridge in the mitogenic activity of the hormone. (1992) (20)
- Enzymatic synthesis of deoxyribo-oligonucleotides of defined sequence. Deoxyribo-oligonucleotide synthesis. (1974) (20)
- Synthetic DNA and Biology (1994) (20)
- Use of E. coli polynucleotide phosphorylase for the synthesis of oligodeoxyribonucleotides of defined sequence. (1980) (19)
- Changes in a mammalian signal sequence required for efficient protein secretion by yeasts. (1990) (19)
- Sequence analysis of the 3' non-coding region of mouse immunoglobulin light chain messenger RNA. (1977) (19)
- Mutational and functional analysis of dominant SPT2 (SIN1) suppressor alleles in Saccharomyces cerevisiae (1993) (17)
- Sequence of the yeast iso-1-cytochrome c mRNA. (1981) (16)
- The chemical synthesis of deoxyribo‐oligonucleotides complementary to a portion of the lysozyme gene of phage T4 and their hybridization to phage specific RNA and phage DNA (1973) (16)
- Oligodeoxyribonucleotides: Chemical Synthesis in Anhydrous Base (1970) (15)
- RNA synthesis and RNA polymerase activities in germ cells of developing rainbow trout testis. (1979) (14)
- Enzymatic synthesis of deoxyribo-oligonucleotides of defined sequence. (1972) (14)
- Recombinant methionyl bovine prolactin: loss of bioactivity after single amino acid deletions from putative helical regions. (1990) (14)
- Enzymatic synthesis of oligodeoxyribonucleotides of defined sequence. Polynucleotide phosphorylase catalysed synthesis using pyrimidine analog-containing deoxyribonucleoside 5'-diphosphates. (1978) (13)
- Enzymatic synthesis of oligonucleotides of defined sequence. Addition of short blocks of nucleotide residues to oligonucleotide primers. (1975) (13)
- DNA sequence of a region of the φX174 genome coding for a ribosome binding site (1977) (12)
- Synthesis of bovine prolactin in Escherichia coli. (1986) (11)
- Use of oligodeoxynucleotide primers to determine poly(adenylic acid) adjacent sequences in messenger ribonucleic acid. 3'-Terminal noncoding sequence of bovine growth hormone messenger ribonucleic acid. (1980) (11)
- Epitope mapping of monoclonal antibodies to bovine prolactin. (1992) (11)
- Isolation and amino acid sequence of neurohypophyseal hormones of Pacific chinook salmon (Oncorhynchus tschwytscha) (1969) (11)
- Construction and properties of a ribosome-binding site mutation in gene E of phi X174 bacteriophage (1984) (10)
- Role of intron splicing in the function of the MATa1 gene of Saccharomyces cerevisiae (1989) (10)
- Enzymatic synthesis of oligodeoxyribonucleotides of defined sequence. Polynucleotide phosphorylase catalysed addition of deoxyribonucleotides to primers which are good or poor acceptors. (1978) (9)
- Rights, Nationalism and Social Movements in Canadian Constitutional Politics (1995) (8)
- A possible mechanism for partitioning between homo- and heterodimerization of the yeast homeodomain proteins MATa1 and MATalpha2. (2002) (8)
- The synthesis of the internucleotide (phosphodiester) bond by a base-catalysed reaction. (1975) (6)
- Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis. (1988) (6)
- Sequence organization in the genomic DNA of the chum salmon, Oncorhynchus keta (1979) (6)
- Synergy of Semisynthesis and Site-Directed Mutagenesis: Manipulating Genes to Create Sites for Autocatalytic Protein Fragment Religation (1992) (4)
- Homoeo-domain homology in yeast MAT alpha 2 is essential for repressor activity. (1986) (4)
- Application of base-catalysed reaction to the synthesis of dinucleotides containing the four common deoxyribonucleosides and of oligodeoxythymidylates. (1975) (4)
- A convenient procedure for the synthesis of oligodeoxyribonucleotide affinity columns for the isolation of mRNA (1988) (3)
- Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum ologodeoxyribonucleotide length. (1979) (2)
- 140 NEAR INFRARED SPECTROSCOPY (NIRS) INTERFERENCE FAULTS DURING NEONATAL DATA COLLECTION (1994) (2)
- Use of a ligand-screening procedure to study the interaction of S. cerevisiae alpha 2 repressor with its operator sequence. (1992) (2)
- SITE-DIRECTED MUTAGENESIS AND PROTEIN ENGINEERING (1990) (2)
- Regulation of transcription of the Saccharomyces cerevisiae CYC1 gene: Identification of a DNA region involved in heme control (2004) (1)
- IN VITRO CONSTRUCTION OF SPECIFIC MUTANTS (1981) (1)
- Efficient expression of theEscherichia coli leuB gene in yeast (2004) (1)
- Nucleotide sequence of the 3' terminal third of rabbit alpha-globin messenger RNA: comparison with human alpha-globin messenger RNA. (1977) (1)
- Applications of synthetic oligodeoxyribonucleotides to problems in molecular biology. (1980) (1)
- Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum oligodeoxyribonucleotide length. 1979. (1992) (1)
- Synthetic oligodeoxyribonucleotides as tools in molecular genetics: the characterization of the CYC1 (iso-1-cytochrome c encoding) locus of Saccharomyces cerevisiae. (1985) (1)
- Oligodeoxyribonucleotides as Site-Specific Mutagens (1981) (1)
- APPENDIX I: The Nucleotide Sequence of the DNA of ϕ X174 cs 70 and the Amino Acid Sequence of the Proteins for Which It Codes (1978) (0)
- Evidence foraNovelGlycinamide Ribonucleotide Transformylase inEscherichia coli (1993) (0)
- Cleavage specificity of the restriction endonuclease isolated from Ha emophil us gallinarum ( Hga I ) * ( DNA sequencing / + X 174 DNA / recognition sequences / cohesive ends ) (2003) (0)
- Construction andProperties ofaRibosome-Binding Site Mutation in GeneE of4X174Bacteriophage (1984) (0)
- Molecular cloning and characterization of protective outer membrane protein P . 69 from Bordetella pertussis 1 (2003) (0)
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