Michael W. Mcburney
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Biology
Michael W. Mcburney's Degrees
- PhD Molecular Biology Stanford University
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Michael W. Mcburney's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (1934)
- Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells (1994) (1463)
- Mammalian SIRT1 Represses Forkhead Transcription Factors (2004) (1400)
- Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells (1982) (778)
- Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008) (747)
- Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005) (695)
- Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line (1982) (671)
- AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009) (611)
- The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis (2003) (523)
- Fate of teratocarcinoma cells injected into early mouse embryos (1975) (474)
- SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice (2008) (451)
- Identification of XAF1 as an antagonist of XIAP anti-Caspase activity (2001) (449)
- Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade (2018) (447)
- SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity (2010) (429)
- Isolation of male embryonal carcinoma cells and their chromosome replication patterns. (1982) (426)
- P19 embryonal carcinoma cells. (1993) (396)
- A local mechanism mediates NAD-dependent protection of axon degeneration (2005) (360)
- The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. (2003) (350)
- SIRT1 Negatively Regulates the Mammalian Target of Rapamycin (2010) (341)
- MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin* (2000) (339)
- SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. (2008) (337)
- Retinoic acid-induced neural differentiation of embryonal carcinoma cells (1983) (328)
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. (2012) (319)
- Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. (1987) (318)
- SIRT1 Regulates HIV Transcription via Tat Deacetylation (2005) (314)
- The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. (2009) (265)
- The concentration of retinoic acid determines the differentiated cell types formed by a teratocarcinoma cell line. (1983) (249)
- Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR* (1999) (243)
- Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells. (1974) (231)
- Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage (2006) (200)
- SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis (2009) (197)
- Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage (2013) (193)
- Induced muscle differentiation in an embryonal carcinoma cell line (1983) (189)
- The mouse Pgk-1 gene promoter contains an upstream activator sequence. (1991) (185)
- The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon (1987) (183)
- Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. (2010) (164)
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. (2008) (163)
- Clonal lines of teratocarcinoma cells in vitro: Differentiation and cytogenetic characteristics (1976) (160)
- Alternative Splicing of the Sodium Channel SCN8A Predicts a Truncated Two-domain Protein in Fetal Brain and Non-neuronal Cells* (1997) (154)
- SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol (2009) (141)
- A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell (1990) (140)
- sirt1-null mice develop an autoimmune-like condition. (2008) (139)
- A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction (2011) (136)
- Poly(D,L lactic-co-glycolic acid) microspheres as biodegradable microcarriers for pluripotent stem cells. (2004) (127)
- Actin and myosin expression during development of cardiac muscle from cultured embryonal carcinoma cells. (1990) (119)
- Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters (1994) (113)
- SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice (2013) (107)
- The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection. (1982) (106)
- Identification of a SIRT1 mutation in a family with type 1 diabetes. (2013) (102)
- Participation of cultured teratocarcinoma cells in mouse embryogenesis. (1978) (100)
- The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals (2005) (99)
- SIRT1-mediated acute cardioprotection. (2011) (95)
- Evidence for repeat-induced gene silencing in cultured Mammalian cells: inactivation of tandem repeats of transfected genes. (2002) (93)
- Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells. (1993) (88)
- Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins (1995) (86)
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. (2014) (83)
- The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1 (2009) (82)
- The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. (2003) (80)
- Sirtuin 1 in immune regulation and autoimmunity (2012) (79)
- Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. (2007) (79)
- Cellular aggregation enhances MyoD-directed skeletal myogenesis in embryonal carcinoma cells (1994) (79)
- Expression of the Brachyury gene during mesoderm development in differentiating embryonal carcinoma cell cultures. (1994) (78)
- The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance (2015) (78)
- A Splice Variant of the ITF-2 Transcript Encodes a Transcription Factor That Inhibits MyoD Activity (*) (1996) (78)
- Multiple CArG boxes in the human cardiac actin gene promoter required for expression in embryonic cardiac muscle cells developing in vitro from embryonal carcinoma cells (1991) (76)
- Genetic activity of X chromosomes in pluripotent female teratocarcinoma cells and their differentiated progeny (1980) (76)
- Murine embryonal carcinoma-derived neurons survive and mature following transplantation into adult rat striatum (1994) (75)
- Dietary restriction: standing up for sirtuins. (2010) (70)
- CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. (2003) (69)
- SirT1 fails to affect p53‐mediated biological functions (2006) (68)
- Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. (2013) (65)
- The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome (2014) (65)
- Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. (2011) (64)
- The role of aggregation in embryonal carcinoma cell differentiation (1987) (63)
- Murine PGK‐1 promoter drives widespread but not uniform expression in transgenic mice (1994) (63)
- P19 Embryonal Carcinoma Cells: A Source of Cultured Neurons Amenable to Genetic Manipulation (1995) (63)
- SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. (2013) (62)
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells. (2006) (61)
- Cell density and cell cycle effects on retinoic acid-induced embryonal carcinoma cell differentiation. (1990) (59)
- A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability. (2016) (59)
- SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons (2011) (58)
- Smooth muscle actin expression during P19 embryonal carcinoma differentiation in cell culture (1990) (56)
- Sedimentation analysis of DNA from irradiated and unirradiated L-cells. (1972) (56)
- SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice (2012) (55)
- Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines (1998) (54)
- Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes (2009) (54)
- Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. (2015) (54)
- SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. (2013) (53)
- SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. (2014) (52)
- Sirt1-deficient mice exhibit an altered cartilage phenotype. (2013) (52)
- Mutants of Chinese hamster cells resistant to adenosine (1975) (51)
- P19 cells differentiate into glutamatergic and glutamate-responsive neurons in vitro (1997) (48)
- Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development (2017) (47)
- Hemoglobin synthesis in cell hybrids formed between teratocarcinoma and friend erythroleukemia cells (1977) (47)
- The family of mouse phosphoglycerate kinase genes and pseudogenes (1988) (46)
- Physiological and clinical aspects of vitamin A and its metabolites. (1992) (46)
- Anomalous sedimentation of high molecular weight denatured mammalian DNA. (1971) (45)
- Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor alpha 1. (1997) (44)
- In vivo electrophysiological maturation of neurons derived from a multipotent precursor (embryonal carcinoma) cell line. (1995) (44)
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. (2010) (42)
- Studies on the activity of the X chromosomes in female teratocarcinoma cells in culture (1976) (42)
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (42)
- Mechanism of growth inhibition by methotrexate. (1975) (41)
- Retinoic acid treated P19 embryonal carcinoma cells differentiate into oligodendrocytes capable of myelination (1996) (41)
- Lineage-specific transformation after differentiation of multipotential murine stem cells containing a human oncogene (1986) (40)
- Retinoids and cancer: a basis for differentiation therapy. (1993) (40)
- Characterization of a Chinese hamster cell with a temperature-sensitive mutation in folate metabolism. (1974) (40)
- Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells (1988) (39)
- The E box is essential for activity of the cardiac actin promoter in skeletal but not in cardiac muscle. (1994) (39)
- Fusion of embryonal carcinoma cells to fibroblast cells, cytoplasts, and karyoplasts. Developmental properties of viable fusion products. (1979) (38)
- X chromosome reactivation in mouse embryonal carcinoma cells (1985) (37)
- DNA methylation of two X chromosome genes in female somatic and embryonal carcinoma cells (1991) (36)
- Cell lines with developmental potential restricted to mesodermal lineages isolated from differentiating cultures of pluripotential P19 embryonal carcinoma cells. (1989) (36)
- The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells. (1989) (34)
- Activation of teratocarcinoma-derived hemoglobin genes in teratocarcinoma-friend cell hybrids (1978) (33)
- Development of parthenogenetic and fertilized mouse embryos in the uterus and in extra-uterine sites. (1975) (32)
- Human long chain, very long chain and medium chain acyl-CoA dehydrogenases are specific for the S-enantiomer of 2- methylpentadecanoyl-CoA. (1998) (31)
- DNA methylation pattern of a tandemly repeated LacZ transgene indicates that most copies are silent (1999) (30)
- Cell-cell interaction modulates myoD-induced skeletal myogenesis of pluripotent P19 cells in vitro. (1999) (30)
- Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver‐mesenteric adipose tissue fatty acid mobilization (2017) (30)
- X chromosome inactivation: a hypothesis. (1988) (28)
- Functional cloning of mouse chromosomal loci specifically active in embryonal carcinoma stem cells (1988) (28)
- Two transient increases in c-myc gene expression during neuroectodermal differentiation of mouse embryonal carcinoma cells. (1988) (28)
- Synthesis and processing of small B2 transcripts in mouse embryonal carcinoma cells (1990) (28)
- WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis (2011) (27)
- Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells (2006) (27)
- Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration. (2015) (26)
- IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. (2019) (26)
- Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor. (1993) (24)
- Intragenic regions of the murinePgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells (1994) (24)
- Sirtuin 1 Is a Negative Regulator of Parathyroid Hormone Stimulation of Matrix Metalloproteinase 13 Expression in Osteoblastic Cells (2015) (23)
- Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner (2019) (23)
- Sirt1-deficiency causes defective protein quality control (2015) (23)
- Identification of a SIRT 1 Mutation in a Family with Type 1 Diabetes (2013) (22)
- Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles (1990) (22)
- Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. (2013) (22)
- Selection for temperature‐sensitive mutants of diploid and tetraploid mammalian cells (1974) (21)
- Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2015) (20)
- Neurons derived from P19 embryonal carcinoma cells develop responses to excitatory and inhibitory neurotransmitters. (1995) (20)
- The rodent B2 sequence can affect expression when present in the transcribed region of a reporter gene. (1991) (20)
- X chromosome inactivation during induced differentiation of a female mouse embryonal carcinoma cell line. (1985) (20)
- Glutamate Receptor‐Mediated Calcium Surges in Neurons Derived from P19 Cells (1995) (20)
- Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles (1990) (20)
- Xist is expressed in female embryonal carcinoma cells with two active X chromosomes (1994) (19)
- Dominant negative mutant of retinoic acid receptor alpha inhibits retinoic acid-induced P19 cell differentiation by binding to DNA. (1996) (19)
- Cell-cell interaction can influence drug-induced differentiation of murine embryonal carcinoma cells. (1985) (18)
- Molecular weight analysis of mammalian DNA. (1972) (18)
- Gene silencing in the development of cancer. (1999) (17)
- Intragenic regions of the murine Pgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells. (1994) (15)
- Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP (2010) (14)
- Genes transfected into embryonal carcinoma stem cells are both lost and inactivated at high frequency (1996) (14)
- Commitment in a murine embryonal carcinoma cell line during differentiation induced by retinoic acid. (1985) (13)
- The Absence of SIR 2 A Protein Has No Effect on Global Gene Silencing in Mouse Embryonic Stem Cells (2003) (13)
- Unstable integration of transfected DNAs into embryonal carcinoma cells (1994) (13)
- SIRT1 Catalytic Activity Has Little Effect on Tumor Formation and Metastases in a Mouse Model of Breast Cancer (2013) (12)
- Reexpression of a cluster of silenced transgenes is associated with their rearrangement (2001) (12)
- E2F inhibits transcriptional activation by the retinoic acid receptor. (1996) (12)
- Formation and fate of heterokaryons involving embryonal carcinoma cells (1982) (11)
- Reactivation ofhprt on the inactive X chromosome with DNA demethylating agents (1989) (10)
- A Role for RNA Processing in Regulating Expression from Transfected Genes (1998) (10)
- corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (9)
- Adenovirus 5 E1A induced differentiation of P19 embryonal carcinoma cells requires binding to p300. (1995) (9)
- Liston, P. et al. Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nature Cell Biol. 3, 128-133 (2001) (8)
- An upstream activator sequence regulates the murine Pgk-1 promoter and binds multiple nuclear proteins. (1995) (8)
- X chromosome inactivation: the feminine mystique continues. (1993) (7)
- Reversible modulation of SIRT1 activity in a mouse strain (2017) (7)
- What the papers say: X chromosome inactivation: The feminine mystique continues (1993) (6)
- Sirt1 enzymatic activity is required for cartilage homeostasis in vivo (2012) (5)
- Food anticipatory activity on a calorie-restricted diet is independent of Sirt1 (2018) (5)
- Supplemental Data Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT 1 through AMPK-Mediated Regulation of Nampt (2008) (5)
- DNA methylation in differentiating mouse teratocarcinoma and erythroleukemia cells. (1984) (5)
- A transfected H-ras oncogene does not inhibit differentiation of cardiac and skeletal muscle from embryonal carcinoma cells. (1989) (4)
- Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK (2020) (4)
- Mechanism of Growth Inhibition by (1974) (4)
- Enhanced transgene expression in embryonal carcinoma stem cells: transcription through introns and exons increases gene copy numbers and forestalls silencing. (2003) (4)
- Restricted replication of herpes simplex virus type 1 in murine embryonal carcinoma cells. (1987) (3)
- Chimeric mice derived from normal embryos injected with teratocarcinoma cells. (1977) (3)
- Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice. (2010) (3)
- Expression of globin genes in teratocarcinoma--Friend cell hybrids. (1981) (3)
- Modulation of Tumorigenesis by Dietary Intervention Is Not Mediated by SIRT1 Catalytic Activity (2014) (2)
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5K[subscript gamma] Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (2)
- SIRT1: Identification of a novel placental stress-response protein that regulates fetal growth? (2013) (2)
- Search of the 5' untranslated region of the human cardiac actin gene for segments controlling translation. (1990) (1)
- Abstract 17301: Increased Pulmonary Vascular and Systemic Response to Chronic Hypoxia in Sirtuin 1 Mutant Mice: a Role for Hypoxia-inducible Factor-3α? (2014) (1)
- Modulating SIRT1 activity variously affects thymic lymphoma development in mice (2018) (1)
- Expression of the human cardiac actin gene in differentiating rat skeletal myoblasts. (1988) (1)
- [Influence of cell-cell interaction upon differentiation of murine embryonal carcinoma cells]. (1987) (1)
- int-1 expression during neuronal differentiation of P19 embryonal carcinoma (EC) cells (1989) (0)
- Altered cartilage phenotype in mice lacking Sirt 1 gene (2013) (0)
- Abstract 13526: Transgenic Mice Lacking Sirt1 or Sirt1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia (2012) (0)
- Abstract LB-266: SIRT1 governs GnRH neuron migration and The Kallmann syndrome phenotype. (2013) (0)
- The mechanism of chemically-induced differentiation of a mouse embryonal carcinoma cell line. (1986) (0)
- The NAD-dependent deacetylase Sirtuin-1 regulates trophoblast differentiation and placental development (2013) (0)
- 60 SIRT1 -DEFICIENT MICE EXHIBIT AN ALTERED CARTILAGE PHENOTYPE AND UNDERGO INCREASED CARTILAGE BREAKDOWN AND APOPTOSIS (2011) (0)
- Abstract LB-133: A novel tumor suppressor role for sirt1 inhibiting mitophagy in prostate mouse tissue. (2013) (0)
- Sirtuin 1 Attenuates Pulmonary Neutrophilic Inflammation In Mice Exposed To Cigarette Smoke (2011) (0)
- Methylation of the G6PD gene in mouse teratocarcinoma cells (1989) (0)
- Deficiency Of SIRT1 Enhances Elastase-induced Emphysema In Mice (2010) (0)
- Synthesis andProcessing ofSmall B2Transcripts inMouse Embryonal Carcinoma Cells (1990) (0)
- CHROMOSOME INACTIVATION DURING INDUCED DIFFERENTIATION OF A FEMALE MOUSE EMBRYONAL CARCINOMA CELL LINE (2005) (0)
- RESVERATROL TREATMENT RESCUES EXAGGERATED RESPONSE TO CHRONIC HYPOXIA IN SIRTUIN-1 MUTANT MICE (2016) (0)
- Enhancer-binding proteins interacting with mouse-pgk-1, the X-linked phosphoglycerate kinase gene (1989) (0)
- Abstract 19440: Dichloroacetate Fails to Improve Exaggerated Chronic-Hypoxia Induced Pulmonary Hypertension in Sirtuin 1 Mutant Mice (2016) (0)
- Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19). (2019) (0)
- The effect of methotrexate on the growth of Chinese hamster cells (0)
- 496 Transgenic Mice Lacking Sirt1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia (2012) (0)
- SIRTUIN 1 PLAYS A CRUCIAL ROLE IN MODULATING THE PULMONARY AND SYSTEMIC HYPOXIC RESPONSE IN MICE: NOVEL ROLE FOR HYPOXIA INDUCIBLE FACTOR-3ALPHA? (2014) (0)
- Functional Cloning ofMouseChromosomal LociSpecifically Active inEmbryonal Carcinoma StemCells (1988) (0)
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