Michael Wakelam
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Why Is Michael Wakelam Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michael John Owen Wakelam was a British molecular biologist and director of the Babraham Institute in Cambridge, England. Biography Wakelam received a BSc in medical biochemistry and a PhD in biochemistry from the University of Birmingham. After post-doctoral training at the University of Konstanz , he joined the Department of Biochemistry of Imperial College London in 1983. In 1985, he joined the Biochemistry department of the University of Glasgow as a Lecturer , Senior Lecturer and Reader . He became a Professor of molecular pharmacology at the University of Birmingham in 1993. In 2007, he became director of the Babraham Institute in Cambridge.
Michael Wakelam's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Shorthand notation for lipid structures derived from mass spectrometry (2013) (585)
- Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development (2006) (532)
- Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress (2015) (531)
- Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014) (416)
- Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production (1986) (331)
- The fusion of myoblasts. (1985) (331)
- Activation of two signal-transduction systems in hepatocytes by glucagon (1986) (326)
- Diacylglycerols and phosphatidates: which molecular species are intracellular messengers? (1998) (295)
- Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA (2012) (273)
- Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells (1995) (261)
- Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry (2011) (252)
- CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. (1996) (223)
- Identification of serum biomarkers for colon cancer by proteomic analysis (2006) (220)
- Stimulation of actin stress fibre formation mediated by activation of phospholipase D (1996) (212)
- Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth (2013) (207)
- PTEN mutations as a cause of constitutive insulin sensitivity and obesity in human beings (2012) (204)
- Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation (1998) (198)
- Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions (1997) (196)
- Diacylglycerol--when is it an intracellular messenger? (1998) (180)
- Extracellular vesicles: lipids as key components of their biogenesis and functions (2018) (168)
- Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments (2016) (159)
- MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines1 (2018) (158)
- Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism. (1989) (156)
- TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid* (2002) (155)
- Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures (2020) (155)
- Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism (2017) (153)
- A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory Motif Protein*S (2007) (152)
- Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes. (1989) (151)
- Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A2 and 5-lipoxygenase catalyzed pathway (2002) (141)
- Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes (1983) (138)
- Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain (2000) (129)
- Interaction of the Type Iα PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5‐bisphosphate in the regulation of PLD2 activity (2000) (124)
- Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection (2020) (119)
- Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. (2005) (117)
- Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4 (1999) (117)
- The regulation of phospholipase D by inositol phospholipids and small GTPases (2002) (117)
- Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. (2001) (116)
- Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration (2012) (115)
- Differential association of cytoplasmic signalling molecules SHP‐1, SHP‐2, SHIP and phospholipase C‐γ1 with PECAM‐1/CD31 (1999) (115)
- Activation of vascular adhesion protein‐1 on liver endothelium results in an NF‐κB–dependent increase in lymphocyte adhesion (2007) (114)
- C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies (2018) (107)
- Deciphering lipid structures based on platform-independent decision rule sets (2017) (105)
- Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells* (1997) (104)
- Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal (2014) (103)
- The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages. (1992) (103)
- C13orf31 (FAMIN) is a central regulator of immunometabolic function (2016) (101)
- Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. (2003) (95)
- Exocytosis of CTLA-4 Is Dependent on Phospholipase D and ADP Ribosylation Factor-1 and Stimulated during Activation of Regulatory T Cells1 (2005) (91)
- Inhibition of Phosphatidylinositol 3-Kinase- and ERK MAPK-regulated Protein Synthesis Reveals the Pro-apoptotic Properties of CD40 Ligation in Carcinoma Cells* (2004) (89)
- Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D. (1991) (88)
- Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. (2002) (83)
- Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis. (1992) (81)
- Analysis of intact phosphoinositides in biological samples Published, JLR Papers in Press, April 21, 2006. (2006) (81)
- Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins. (1992) (81)
- Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients (2007) (77)
- Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels (2009) (76)
- LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training (2019) (75)
- LipidHome: A Database of Theoretical Lipids Optimized for High Throughput Mass Spectrometry Lipidomics (2013) (73)
- lazaro Encodes a Lipid Phosphate Phosphohydrolase that Regulates Phosphatidylinositol Turnover during Drosophila Phototransduction (2006) (72)
- Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. (2006) (70)
- Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs). (1989) (70)
- Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18. (2004) (69)
- Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M. (2002) (66)
- The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism. (1987) (65)
- P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. (2015) (64)
- Proteomic profiling of urine for the detection of colon cancer (2008) (64)
- Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4 (2014) (63)
- Phospholipid signaling in innate immune cells. (2018) (61)
- Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine (2020) (61)
- MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability (2007) (61)
- A nutritional memory effect counteracts benefits of dietary restriction in old mice (2019) (60)
- Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins. (1988) (59)
- Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium. (2005) (59)
- Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells. (1996) (59)
- Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Iγb (2005) (58)
- Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts. (1990) (58)
- Acute Manipulation of Diacylglycerol Reveals Roles in Nuclear Envelope Assembly & Endoplasmic Reticulum Morphology (2012) (58)
- Adipsin and the Glucose Transporter GLUT4 Traffic to the Cell Surface via Independent Pathways in Adipocytes (2000) (55)
- Diacylglycerol Kinase ε, but Not ζ, Selectively Removes Polyunsaturated Diacylglycerol, Inducing Altered Protein Kinase C Distribution in Vivo * (1999) (55)
- Lipidomics: Current state of the art in a fast moving field (2019) (54)
- Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation. (1996) (53)
- Using lipidomics analysis to determine signalling and metabolic changes in cells. (2017) (52)
- The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication (2019) (52)
- The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells. (1991) (52)
- Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton. (2009) (51)
- Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation. (1993) (51)
- Widespread distribution of Gqα/Gllα detected immunologically by an antipeptide antiserum directed against the predicted C‐terminal decapeptide (1991) (50)
- Second‐messenger pathways involved in the regulation of survival in germinal‐centre B cells and in burkitt lymphoma lines (1992) (47)
- Modulation of Triglyceride and Cholesterol Ester Synthesis Impairs Assembly of Infectious Hepatitis C Virus* (2014) (47)
- Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts. (1990) (47)
- Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication. (2017) (46)
- Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations (2016) (46)
- Runx regulation of sphingolipid metabolism and survival signaling. (2010) (44)
- Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms (2013) (43)
- Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. (2000) (43)
- Speed and Sensitivity of Phototransduction in Drosophila Depend on Degree of Saturation of Membrane Phospholipids (2015) (43)
- Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems. (1988) (43)
- Lipidomic analysis of signaling pathways. (2007) (43)
- MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer (2020) (43)
- Inositol phospholipid metabolism and myoblast fusion. (1983) (41)
- Diacylglycerol Induces Fusion of Nuclear Envelope Membrane Precursor Vesicles* (2005) (40)
- PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly. (2007) (40)
- Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells (2016) (39)
- SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae. (2001) (37)
- Phospholipases C and D in mitogenic signal transduction. (1992) (36)
- Phospholipase D. (1997) (36)
- PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fcγ-receptor-stimulated ROS production in neutrophils (2011) (36)
- The control of glucose 1,6-bisphosphate by developmental state and hormonal stimulation in cultured muscle tissue. (1982) (35)
- Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle. (1994) (35)
- Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation. (2007) (35)
- Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis (2015) (35)
- Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18. (2007) (35)
- Prostaglandins and cyclic AMP stimulate creatine kinase synthesis but not fusion in cultured embryonic chick muscle cells. (1984) (35)
- Analysis of intact phosphoinositides in biological samples (2006) (34)
- Phospholipase D. (2004) (33)
- Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. (2020) (32)
- Hydrolysis of phosphatidylcholine by phospholipase D is a common response to mitogens which stimulate inositol lipid hydrolysis in Swiss 3T3 fibroblasts. (1991) (32)
- Modeling Meets Metabolomics—The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans (2018) (31)
- Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling (2016) (31)
- Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets[S] (2018) (31)
- Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts. (1991) (31)
- Mammalian phospholipase D: Function, and therapeutics. (2019) (31)
- Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis. (1991) (30)
- Antagonistic roles for phospholipase D activities in B cell signaling: while the antigen receptors transduce mitogenic signals via a novel phospholipase D activity, phosphatidylcholine-phospholipase D mediates antiproliferative signals. (1998) (29)
- Interleukin-2 Causes an Increase in Saturated/Monounsaturated Phosphatidic Acid Derived from 1,2-Diacylglycerol and 1-O-Alkyl-2-acylglycerol* (1999) (29)
- Quality control requirements for the correct annotation of lipidomics data (2021) (29)
- Regulation by hypoxia of endothelin‐1‐stimulated phospholipase D activity in sheep pulmonary artery cultured smooth muscle cells (1994) (29)
- The proto‐oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer (2016) (29)
- Vasopressin‐stimulated [3H]‐inositol phosphate and [3H]‐phosphatidylbutanol accumulation in A10 vascular smooth muscle cells (1992) (28)
- Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo. (1999) (28)
- Assessment of novel combinations of biomarkers for the detection of colorectal cancer. (2011) (27)
- Serum matrix metalloproteinase 9 and colorectal neoplasia: a community-based evaluation of a potential diagnostic test (2012) (26)
- The measurement of phospholipase D-linked signaling in cells. (1995) (25)
- Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein. (1990) (24)
- Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway. (1994) (24)
- BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. (2021) (24)
- Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population (2006) (23)
- The control of glucose 1,6-bisphosphatase by Ca2+ and calmodulin. (1982) (23)
- The breakdown of phosphatidylinositol in myoblasts stimulated to fuse by the addition of Ca2+. (1982) (22)
- Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells. (1992) (21)
- Rapid desensitization and resensitization of bombesin-stimulated phospholipase D activity in Swiss 3T3 cells. (1994) (21)
- Methods for analyzing phosphoinositides using mass spectrometry. (2011) (21)
- G-proteins : signal transduction and disease (1992) (20)
- Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells. (1992) (20)
- Activation of inositol phospholipid breakdown by prostaglandin F2 alpha without any stimulation of proliferation in quiescent NIH-3T3 fibroblasts. (1990) (19)
- Mass measurement of inositol phosphates. (1989) (19)
- Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options (2015) (19)
- Lipidomics in the analysis of malignancy. (2014) (19)
- The co-mitogenic combination of transforming growth factor beta 1 and bombesin protects protein kinase C-delta from late-phase down-regulation, despite synergy in diacylglycerol accumulation. (1996) (19)
- Role and regulation of phospholipase D activity in normal and cancer cells. (1997) (18)
- Mechanical and biochemical responses to endothelin-1 and endothelin-3 in human bronchi. (1994) (17)
- Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon. (1989) (17)
- L6 skeletal muscle cells have functional V1‐vasopressin receptors coupled to stimulated inositol phospholipid metabolism (1987) (17)
- The mediator is the message: is it part of the answer of insulin's action? (1986) (17)
- Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels (2018) (16)
- Insulin and platelet-derived growth factor acutely stimulate glucose transport in 3T3-L1 fibroblasts independently of protein kinase C. (1993) (16)
- Distinct phospholipase C‐regulated signalling pathways in Swiss 3T3 fibroblasts induce the rapid generation of the same polyunsaturated diacylglycerols (1998) (16)
- Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene. (1989) (16)
- Antigen-stimulated Activation of Phospholipase D 1 b by Rac 1 , ARF 6 , and PKC in RBL-2 H 3 Cells (2002) (15)
- Glucagon stimulates adenylate cyclase through GR2 glucagon receptors: a process which can be attenuated by glucagon stimulating inositol phospholipid metabolism through GR1 glucagon receptors. (1987) (15)
- C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies (2018) (15)
- Phosphatidylinositolphosphate phosphatase activities and cancer (2016) (15)
- Regulation of the hydrolysis of phosphatidylcholine in Swiss 3T3 cells. (1991) (15)
- The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies. (2014) (14)
- Accurate measurement of sn-1,2-diradylglycerol mass in cell lipid extracts. (1991) (14)
- A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. (2000) (14)
- A Dual Role for Diacylglycerol Kinase Generated Phosphatidic Acid in Autoantibody-Induced Neutrophil Exocytosis (2011) (14)
- Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide. (1991) (13)
- Myoblast fusion and inositol phospholipid breakdown: causal relationship or coincidence? (1984) (13)
- 3T3-L1 adipocytes express two isoforms of phospholipase D in distinct subcellular compartments. (1999) (13)
- Stimulated inositol phospholipid breakdown and myoblast fusion. (1986) (13)
- v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis. (1992) (13)
- Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans (2015) (12)
- Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer (2013) (12)
- 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers (2018) (12)
- The Ins(1,4,5)P3 binding site of bovine adrenocortical microsomes: function and regulation. (1989) (12)
- Knockdown of Diacylglycerol Kinase Delta Inhibits Adipocyte Differentiation and Alters Lipid Synthesis (2012) (11)
- Inhibition by glucocorticoid and staurosporine of IL‐4‐dependent CD23 production in B lymphocytes is reversed on engaging CD40 (1993) (11)
- A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel ITIM protein (2007) (10)
- SnapShot: Lipid Kinases and Phosphatases (2013) (10)
- An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles (2008) (10)
- The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. (1989) (10)
- The role of N-ras p21 in the coupling of growth factor receptors to inositol phospholipid turnover. (1987) (9)
- Metformin increases 18F-FDG flux and inhibits fatty acid oxidation at clinical doses in breast cancer: Results of a phase 0 clinical trial (2016) (9)
- Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism. (1989) (9)
- Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells (2021) (9)
- Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress (2014) (9)
- Phosphatidylcholine hydrolysis: a source of multiple lipid messenger molecules. (1993) (9)
- CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways (2018) (9)
- Measurement of intracellular inositol 1,4,5-trisphosphate concentrations in unstimulated and vasopressin-stimulated rat hepatocytes using a novel inositol 1,4,5-trisphosphate-specific binding assay (1988) (8)
- Inhibition of the amplified bombesin‐stimulated inositol phosphate response in N‐ras transformed cells by high density culturing (1988) (8)
- Regulation of 'signalling diacylglycerol' in cells: the importance of diacylglycerol kinase. (1996) (8)
- Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis (2017) (7)
- Phospholipase A2 (EC 3.1.1.4) and D (EC 3.1.4.4) signalling in lymphocytes (1998) (7)
- Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans (2021) (7)
- Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications (2020) (7)
- Establishing the added benefit of measuring MMP9 in FOB positive patients as a part of the Wolverhampton colorectal cancer screening programme (2009) (6)
- 41 Differential expression of human phospholipase D genes (1997) (6)
- A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer (2006) (6)
- HL60 nuclei lacking the nuclear double membrane contain a PLD activity which is insensitive to the ADP-ribosylation factor. (1997) (6)
- The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia (2016) (6)
- Analysis of mammalian ras effector function. (1988) (6)
- Responses of glucose 1,6-bisphosphate in myoblasts and myotubes to α-and β-hormonal stimulation (1981) (6)
- Phosphatidylcholine hydrolysis: a multiple messenger generating system. (1993) (6)
- Heterologous desensitization of bombesin‐ and vasopressin‐stimulated phospholipase D activity in Swiss 3T3 fibroblasts (1995) (5)
- Desensitization of prostaglandin F2 alpha-stimulated inositol phosphate generation in NIH-3T3 fibroblasts transformed by overexpression of normal c-Ha-ras-1, c-Ki-ras-2 and c-N-ras genes. (1990) (5)
- SnapShot: Lipid Kinase and Phosphatase Reaction Pathways (2014) (5)
- The effects of p21N-ras expression in NIH-3T3 cells upon cyclic AMP metabolism. (1989) (5)
- Diacylglycerols and phosphatidates: which molecular species are (1998) (5)
- Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans (2017) (5)
- Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin. (1997) (5)
- Mass measurement of Ins(1,4,5)P3 using a specific binding assay (1990) (4)
- Amplification of fluoroaluminate-stimulated inositol phosphate generation in a cell line overexpressing the p21N-ras gene. (1989) (4)
- Glucose 1,6-bisphosphatase and the control of glucose 1,6-bisphosphate in muscle (1983) (4)
- The regulation by phosphorylation of ‘priming’ of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells (1997) (4)
- BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS (2021) (4)
- The role of ras gene products in second messenger generation. (1990) (4)
- Chapter 15 Structure and function of the receptor for insulin (1988) (4)
- A role for phospholipase D activation in B cell activation. (1993) (3)
- THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation (2020) (3)
- The antigen receptors on B and T cells are not coupled to cytosolic phospholipase A2 activation and arachidonic acid release. (1993) (3)
- Endothelin stimulates phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis in Rat-1 cells. (1990) (3)
- The identification of several stearoyl-arachidonyl selective diacylglycerol kinases in the particulate fraction of porcine testes. (1993) (3)
- Homologous desensitization of bombesin-stimulated Ins(1,4,5)P3 production in Swiss 3T3 fibroblasts. (1991) (2)
- Identification and Quantification of Lipids Using Mass Spectrometry (2007) (2)
- The search for new targets for cancer chemotherapeutics. (2005) (2)
- Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism. (1990) (2)
- Assays to study phospholipase D regulation by inositol phospholipids and ADP-ribosylation factor 6. (2005) (2)
- Confounding Effects of Benign Lung Diseases on Non-Small Cell Lung Cancer Serum Biomarker Discovery (2009) (2)
- Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK (2019) (2)
- Desensitization of prostaglandin F2α-stimulated inositol phosphate generation in ras-transformed cells (1988) (1)
- Biochemical Society Symposium: 74 (2007) (1)
- Registrars' Symposium (2014) (1)
- The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear (2022) (1)
- Differences in the coupling of ET-1 and LPA receptors in Ins(1,4,5)P3 formation in Rat-1 fibroblasts. (1991) (1)
- Using lipidomics pathway analysis to identify potential therapeutic targets (2018) (1)
- Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth (2013) (1)
- Cross-talk between phospholipase D and MAP kinases activities. (2010) (1)
- Reply: Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients (2008) (1)
- Lung cancer resection does not change characteristic serum proteomic profiles. (2006) (1)
- Signal Transduction in Proliferating Normal and Transformed Cells (1990) (1)
- Epidermal growth factor stimulates phospholipase D activity in the absence of inositol lipid hydrolysis in Swiss 3T3 cells. (1991) (1)
- The Function of the Mammalian Ras Proteins (1989) (1)
- A neuronal thermostat controls membrane fluidity in C. elegans (2019) (1)
- C. Elegans Eats Its Own Intestine to Make Yolk: A Cause of Senescent Polymorbidity (2018) (1)
- Determination of phospholipase D, lysophospholipase D and DG kinase signaling pathways in disease states by mass spectrometry. (2008) (1)
- PEPTIDE RECEPTORS IN THE BRAIN AND PERIPHERY (1984) (1)
- H₂ formation on interstellar dust grains: The viewpoints of theory, experiments, models and observations (2017) (1)
- Author response: Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling (2016) (0)
- PTEN mutations predisposing to monogenic cancer syndrome cause constitutive insulin sensitivity and obesity in humans (2012) (0)
- 74. The phospholipase D signal transduction pathway is up-regulated in multidrug resistant breast cancer cells (1995) (0)
- Stratification by DNA Damage-Induced Apoptotic and Transcriptional Responses Provides Insight into the Molecular Mechanisms Underlying Blast Clearance Rates in Paediatric B-Precursor ALL. (2006) (0)
- Phosphatidyl inositol 3' kinase-independent p70 S6 kinase activation by FGF receptor-1 is important for proliferation but not differentiation of endothelial cells. (1997) (0)
- Changes in the activities and cellular localisation of phospholipases in differentiating HL-60 cells. (1993) (0)
- Introduction: Signal activated phospholipases. (1997) (0)
- Identification of Novel Signalling Pathways in Myeloblasts from Patients with Acute Myeloid Leukemia Using a Phosphoproteomic Strategy. (2005) (0)
- The role and regulation of phospholipase D in cellular stimulation (2001) (0)
- PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of in fl ammation (2015) (0)
- The regulation of agonist-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. (1993) (0)
- Signal transduction in Rat-1 fibroblasts expressing high levels of the alpha 2-C10 adrenergic receptor. (1991) (0)
- Summary Phospholipase D 2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase I γ b (2005) (0)
- A nutritional memory impairs survival, transcriptional and metabolic response to dietary restriction in old mice (2019) (0)
- Contributors (2022) (0)
- University of Birmingham Establishing the added benefit of measuring MMP9 in FOB positive patients as a part of the Wolverhampton colorectal cancer screening programme (2009) (0)
- Effect of muscle cell differentiation upon G-protein levels. (1990) (0)
- Abstract LB-200: Integrating dynamic 18F-FDG PET-CT, tumor metabolomics and functional genomics to understand metformin's pharmacodynamic effects in breast cancer: results of a phase 0 clinical trial (2016) (0)
- Methods of lipid analysis (2021) (0)
- 1018 Vascular adhesion protein-1 ligation andenzyme activity lead to PI-3 kinase dependent activation of NF-ϰB inhepaticsinusoidal endothelial cells (2003) (0)
- Book reviews (1995) (0)
- A Reassessment of Phosphatidylinositol Transfer Protein Alpha's Growth Factor Signaling Role (2019) (0)
- Epidermal growth factor-regulated signal transduction in hormone dependent and independent breast cancer. (1996) (0)
- Dixie's land (2017) (0)
- Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. (2020) (0)
- Protein kinase C: Current concepts and future perspectives (1993) (0)
- The activity of MMP-2 is increased in human colorectal cancer (1998) (0)
- Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets in (2018) (0)
- Mechanical andbiochemical responsestoendothelin- and endothelin-3 inbovine bronchial smooth muscle (1994) (0)
- Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments (2016) (0)
- Pre-clinical investigation of therapy for segmental overgrowth caused by constitutive activation of phosphoinositide-3 kinas: lessons for cancer therapy (2013) (0)
- THE CONTROL OF sn-1,2-DIACYLGLYCEROL LEVELS IN STIMULATED CELLS (1996) (0)
- Mediates Antiproliferative Signals Phosphatidylcholine-Phospholipase D Signals Via a Novel Phospholipase D Activity, Antigen Receptors Transduce Mitogenic Activities in B Cell Signaling: While the Antagonistic Roles for Phospholipase D (1998) (0)
- PLD1b is activated by Rac1, ARF6 and PKCα in RBL-2H3 cells (2001) (0)
- A Central Role for Syk in the Activation of Neutrophils by Anti-Neutrophil Cytoplasm Antibodies (2003) (0)
- Changes in the metabolism of inositol phospholipids with myoblast fusion (1981) (0)
- Serological pre-hospital detection of colorectal neoplasia in a symptomatic cohort - the next step towards a population screening programme (2000) (0)
- An intracellular motif of GLUT 4 regulates fusion of GLUT 4-containing vesicles (2008) (0)
- Effects of transformation by p21N-ras upon the inositol phospholipid and adenylate cyclase signaling pathways in NIH 3T3 cells. (1988) (0)
- Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism (2017) (0)
- Comprehensive lipidome of human plasma using minimal sample manipulation by liquid chromatography coupled with mass spectrometry. (2023) (0)
- Abstract 1441: MYC expression promotes lipid metabolism and metabolic plasticity in human mammary epithelial cells (2018) (0)
- MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer (2020) (0)
- Regulatory T Cells Factor-1 and Stimulated during Activation of Phospholipase D and ADP Ribosylation Exocytosis of CTLA-4 Is Dependent on (2005) (0)
- The Role Of Guanine Nucleotide Exchange Factors (GEFs) On Pulmonary Leukocyte Recruitment In Vivo (2012) (0)
- G-proteins and second messengers in mitogenesis. (1989) (0)
- Phospholipase D localization and substrate specificity (2001) (0)
- Growing pains (1990) (0)
- Lipid systems and techniques. Introduction. (2009) (0)
- Determination of phospholipase C- or phospholipase D-catalyzed phosphatidylcholine hydrolysis. (1998) (0)
- Gas phase Elemental abundances in Molecular cloudS (GEMS) III. Unlocking the CS chemistry: the CS+O reaction (2020) (0)
- Multiple sources of sn-1,2-diacylglycerol in mitogen-stimulated Swiss 3T3 cells; evidence for activation of phosphoinositidase C and PtdChophospholipase D (1991) (0)
- Desensitization of Glucagon-Stimulated Adenylate Cyclase is Mediated by Stimulation of Inositol Phospholipid Metabolism (1987) (0)
- Lipid Signaling Disease Phosphatidylinositolphosphate phosphatase activities and cancer (2016) (0)
- PL13Investigation of lipid signalling pathways by mass spectrometry (2010) (0)
- A Reevaluation of the Role of Phosphatidylinositol Transfer Protein a in Growth Factor Signaling (2018) (0)
- C . elegans Eats Its Own In testine to Make Yolk Leading to Multiple Senescent Pathologies Graphical (2018) (0)
- Glucagon desensitisation of adenylate cyclase in hepatocytes: an action mediated by a distinct population of glucagon receptors coupled to inositol phospholipid metabolism (1987) (0)
- Abstract A24: Integration of tumor metabolomics, cancer genome sequencing and dynamic functional imaging to assess the metabolic effects of metformin in breast cancer (2015) (0)
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