Michael Weiss
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Michael Weiss's Degrees
- PhD Biochemistry University of California, Berkeley
- Doctorate Medicine University of California, San Francisco
Why Is Michael Weiss Influential?
(Suggest an Edit or Addition)Michael Weiss's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Enterohepatic Circulation (2002) (460)
- Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts (2007) (61)
- Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process. (2001) (61)
- Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug. (2002) (60)
- Moments of physiological transit time distributions and the time course of drug disposition in the body (1982) (57)
- TOPFIT 2.0 Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC, Günter Heinzel, Rolf Woloszcak, Peter Thomann. Gustav Fischer Verlag, Stuttgart-Jena-New York (1993), 647 pages. Soft cover DM 198.-. US-ISBN 1-56081-368-7., ISBN: 3-437-11486-7 (1994) (52)
- The Anomalous Pharmacokinetics of Amiodarone Explained by Nonexponential Tissue Trapping (1999) (49)
- A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability Studies (1996) (47)
- Pharmacokinetic model based on circulatory transport (1979) (46)
- Classification of dissolution profiles in terms of fractional dissolution rate and a novel measure of heterogeneity. (2003) (45)
- Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2 (2016) (45)
- Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: Application of a stochastic model to the rat hindlimb (1996) (43)
- Dynamics of drug distribution. I. Role of the second and third curve moments (1992) (39)
- On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed. (1997) (39)
- Effects of cardiac output on disposition kinetics of sorbitol: recirculatory modelling. (2003) (36)
- P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling. (2002) (34)
- Does the Dose-Solubility Ratio Affect the Mean Dissolution Time of Drugs? (1999) (33)
- Use of gamma distributed residence times in pharmacokinetics (2004) (33)
- Digoxin uptake, receptor heterogeneity, and inotropic response in the isolated rat heart: a comprehensive kinetic model. (2002) (32)
- The relevance of residence time theory to pharmacokinetics (2005) (30)
- Pharmacokinetics in organs and the intact body: model validation and reduction. (1999) (30)
- Cytoplasmic binding and disposition kinetics of diclofenac in the isolated perfused rat liver (2000) (28)
- A note on the interpretation of tracer dispersion in the liver. (1997) (27)
- Systematic screening for pharmacokinetic interactions during drug development. (1996) (27)
- A general model of metabolite kinetics following intravenous and oral administration of the parent drug (1988) (25)
- A note on the rôle of generalized inverse Gaussian distributions of circulatory transit times in pharmacokinetics (1984) (24)
- Commentary: using the convection-dispersion model and transit time density functions in the analysis of organ distribution kinetics. (2000) (23)
- use of Metabolite AUC Data in Bioavailability Studies to Discriminate Between Absorption and First-Pass Extraction (1990) (22)
- Kinetic analysis of vascular marker distribution in perfused rat livers after regeneration following partial hepatectomy. (1998) (22)
- Modelling of initial distribution of drugs following intravenous bolus injection (2004) (21)
- Transit time dispersion in pulmonary and systemic circulation: effects of cardiac output and solute diffusivity. (2006) (21)
- Hemodynamic influences upon the variance of disposition residence time distribution of drugs (1983) (21)
- On pharmacokinetics in target tissues. (1985) (19)
- Pharmacokinetic curve fitting using numerical inverse Laplace transformation. (1999) (19)
- A Note on Population Analysis of Dissolution‐Absorption Models Using the Inverse Gaussian Function (2008) (19)
- Assessing Steatotic Liver Function after Ischemia-Reperfusion Injury by In Vivo Multiphoton Imaging of Fluorescein Disposition (2015) (19)
- Influence of P-Glycoprotein Modulators on Cardiac Uptake, Metabolism, and Effects of Idarubicin (2001) (19)
- Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves (1986) (18)
- Residence time and accumulation of drugs in the body. (1981) (18)
- Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital. (2003) (17)
- Hepatic structure‐pharmacokinetic relationships: The hepatic disposition and metabolite kinetics of a homologous series of O‐acyl derivatives of salicylic acid (1998) (16)
- Modeling Heterogeneity of Particles and Random Effects in Drug Dissolution (2001) (16)
- A stochastic differential equation model for drug dissolution and its parameters. (2004) (16)
- Inotropic Effect of Digoxin in Humans: Mechanistic Pharmacokinetic/Pharmacodynamic Model Based on Slow Receptor Binding (2004) (15)
- Circulatory model of vascular and interstitial distribution kinetics of rocuronium: a population analysis in patients (2011) (15)
- Circulatory transport and capillary-tissue exchange as determinants of the distribution kinetics of inulin and antipyrine in dog. (2007) (15)
- Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin. (2008) (15)
- Pharmacokinetics of ceftriaxone in plasma and bone of patients undergoing hip or knee surgery (2014) (14)
- A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach (2007) (14)
- Pharmacokinetics and tissue distribution of idarubicin and its active metabolite idarubicinol in the rabbit (1997) (14)
- Cellular Pharmacokinetics: Effects of Cytoplasmic Diffusion and Binding on Organ Transit Time Distribution (1999) (14)
- Down-Regulation of Na+ Pump α2 Isoform in Isoprenaline-Induced Cardiac Hypertrophy in Rat: Evidence for Increased Receptor Binding Affinity but Reduced Inotropic Potency of Digoxin (2005) (14)
- Chiral separation of the β2-sympathomimetic fenoterol by HPLC and capillary zone electrophoresis for pharmacokinetic studies. (2010) (13)
- Trospium chloride is absorbed from two intestinal "absorption windows" with different permeability in healthy subjects. (2016) (13)
- Systems analysis of digoxin kinetics and inotropic response in the rat heart: effects of calcium and KB-R7943. (2004) (13)
- Theorems on log-convex disposition curves in drug and tracer kinetics. (1985) (13)
- Modeling the Kinetics of Digoxin Absorption: Enhancement by P‐Glycoprotein Inhibition (2012) (12)
- Residence Time Distributions in Pharmacokinetics: Behavioral and Structural Models (1991) (12)
- Hepatic disposition and metabolite kinetics of a homologous series of diflunisal esters. (1998) (12)
- The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. (2012) (12)
- An Improved Nonlinear Model Describing the Hepatic Pharmacokinetics of Digoxin: Evidence for Two Functionally Different Uptake Systems and Saturable Binding (2010) (12)
- Cardiac output and systemic transit time dispersion as determinants of circulatory mixing time: a simulation study. (2009) (12)
- Pharmacokinetics of idarubicin in the isolated perfused rat lung: effect of cinchonine and rutin (2003) (11)
- Analysis of metabolite formation pharmacokinetics after intravenous and oral administration of the parent drug using inverse Laplace transformation. (1998) (11)
- Definition of pharmacokinetic parameters: Influence of the sampling site (1984) (11)
- Kinetic analysis of myocardial uptake and negative inotropic effect of amiodarone in rat heart. (2006) (11)
- Hepatocellular Necrosis, Fibrosis and Microsomal Activity Determine the Hepatic Pharmacokinetics of Basic Drugs in Right-Heart-Failure-Induced Liver Damage (2012) (10)
- Functional characterization of hepatic transporters using intravital microscopy. (2013) (10)
- Comparison of distributed and compartmental models of drug disposition: assessment of tissue uptake kinetics (2016) (10)
- An Isolated In-Situ Rat Head Perfusion Model for Pharmacokinetic Studies (2000) (10)
- Errors in Clearance Estimation After Bolus Injection and Arterial Sampling: Nonexistence of a Central Compartment (1997) (10)
- Functional characterization of drug uptake and metabolism in the heart (2011) (10)
- A physiologically based model of hepatic ICG clearance: interplay between sinusoidal uptake and biliary excretion. (2011) (10)
- On the Degree of Solute Mixing in Liver Models of Drug Elimination (1997) (9)
- Relative Dispersions of Intra‐albumin Transit Times across Rat and Elasmobranch Perfused Livers, and Implications for Intra‐ and Inter‐species Scaling of Hepatic Clearance using Microsomal Data (1998) (9)
- Kinetic Analysis of Saturable Myocardial Uptake of Idarubicin in Rat Heart: Effect of Doxorubicin and Hypothermia (2004) (9)
- Empirical models for fitting of oral concentration time curves with and without an intravenous reference (2017) (8)
- Mechanism-based modeling of reduced inotropic responsiveness to digoxin in endotoxemic rat hearts. (2005) (8)
- Pharmacokinetic Drug‐Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects (2020) (8)
- Interpretation of general measures of distribution kinetics in terms of a mammillary compartmental model. (1997) (8)
- Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. II. Log-concave concentration-time curves following oral administration (1987) (8)
- Distribution kinetics of solutes in the isolated in‐situ perfused rat head using the multiple indicator dilution technique and a physiological two‐barrier model (2002) (8)
- Nonidentity of the steady-state volumes of distribution of the eliminating and noneliminating system. (1991) (8)
- Distribution Kinetics of Diazepam, Lidocaine and Antipyrine in the Isolated Perfused Rat Hindlimb (2004) (7)
- A model for transit time distributions through organs that accounts for fractal heterogeneity. (2012) (7)
- Residence Time Dispersion as a General Measure of Drug Distribution Kinetics: Estimation and Physiological Interpretation (2007) (7)
- Washout time versus mean residence time. (1988) (7)
- Model-independent assessment of accumulation kinetics based on moments of drug disposition curves (2004) (6)
- Sensitivity of Empirical Metrics of Rate of Absorption in Bioequivalence Studies (2000) (6)
- Mechanistic modeling of digoxin distribution kinetics incorporating slow tissue binding. (2007) (6)
- Caffeine enhances myocardial uptake of idarubicin but reverses its negative inotropic effect (2003) (6)
- An empirical model for dissolution profile and its application to floating dosage forms. (2014) (6)
- Metabolite residence time: influence of the first-pass effect. (1986) (6)
- Importance of tissue distribution in determining drug disposition curves. (1983) (6)
- How does obesity affect residence time dispersion and the shape of drug disposition curves? Thiopental as an example (2008) (6)
- Drug metabolite kinetics: noncompartmental analysis [letter] (1985) (6)
- Determinants of [13N]ammonia kinetics in hepatic PET experiments: a minimal recirculatory model (2002) (5)
- Mean residence time in non‐linear systems? (1988) (5)
- Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged‐Release Ketamine With Emphasis on 2,6‐Hydroxynorketamines (2021) (5)
- Distribution and Binding Kinetics of Ciprofloxacin and Ofloxacin in the Hindlimb of the Rat (1999) (5)
- Reduced uptake of liposomal idarubicin in the perfused rat heart (2008) (5)
- Human insulin dynamics in women: a physiologically based model. (2016) (5)
- Effects of the P‐Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4‐Way Crossover Drug‐Drug Interaction Study in Healthy Subjects (2019) (5)
- Population Pharmacokinetics of Levofloxacin in Plasma and Bone of Patients Undergoing Hip or Knee Surgery (2018) (5)
- Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma. (2003) (5)
- Cardiac pharmacokinetics and inotropic response of verapamil in rats with endotoxemia. (2008) (5)
- Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart (2011) (4)
- Modeling heterogeneity of properties and random effects in drug dissolution. (2001) (4)
- Drug metabolite kinetics: noncompartmental analysis. (1985) (4)
- Pharmacokinetics of Trapidil in Patients with Chronic Liver Disease (1996) (4)
- Commentary to “pharmacokinetics from a dynamical systems point of view” (1989) (3)
- Hepatic interaction between quinidine and digoxin: role of inhibition of sinusoidal Na⁺/K⁺ ATPase digoxin binding. (2012) (3)
- Kinetics of propranolol uptake in muscle, skin, and fat of the isolated perfused rat hindlimb. (2000) (3)
- Steady-state distribution volume in physiologic multi-organ systems. (1983) (3)
- Estimation of Sinusoidal Flow Heterogeneity in Normal and Diseased Rat Livers from Tracer Dilution Data Using a Fractal Model (2012) (3)
- Modeling Cardiac Uptake and Negative Inotropic Response of Verapamil in Rat Heart: Effect of Amiodarone (2006) (3)
- Effects of idarubicin and idarubicinol on rat coronary resistance and vasoconstrictor responsiveness of isolated aorta and mesentery (2006) (3)
- The dynamics of drug distribution as assessed by the second and third curve moments (1990) (3)
- Role of heterogeneity in deterministic models of drug dissolution and their statistical characteristics. (2003) (3)
- Modelling of α1‐adrenoceptor‐mediated temporal dynamics of inotropic response in rat heart to assess ligand binding and signal transduction parameters (2009) (3)
- Fractal structure of the liver: effect on drug elimination (2013) (2)
- Modeling the influence of non-adherence on antibiotic efficacy: application to ciprofloxacin. (2007) (2)
- Unusual Distribution Kinetics of Gadoxetate in Healthy Human Subjects Genotyped for OATP1B1: Application of Population Analysis and a Minimal Physiological-Based Pharmacokinetic Model. (2020) (2)
- Modeling the heterogeneous intestinal absorption of propiverine extended-release. (2015) (2)
- Modeling accelerated and decelerated drug release in terms of fractional release rate. (2015) (2)
- Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin (2022) (2)
- Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets (2023) (1)
- Exponential tails of drug disposition curves: Reality or appearance? (2014) (1)
- Pharmacokinetic-pharmacodynamic modeling of the effect of propofol on alpha 1-adrenoceptor-mediated positive inotropy in rat heart. (2009) (1)
- Population pharmacokinetics of cefuroxime and uptake into hip and spine bone of patients undergoing orthopaedic surgery (2019) (1)
- Accuracy of noncompartmental pharmacokinetic parameters estimated from bolus injection and steady-state infusion data (1995) (1)
- Physiological Modelling and the Effect Site (2000) (1)
- Effect of disease states on α1‐adrenoceptor binding and signal transduction parameters in isolated perfused heart: quantification by pharmacokinetic‐pharmacodynamic modelling (2014) (1)
- Empirical models for fitting of oral concentration time curves with and without an intravenous reference (2017) (0)
- Argenio Function A Note on Population Analysis of Dissolution-Absorption Models Using the Inverse Gaussian (2008) (0)
- Comparison of distributed and compartmental models of drug disposition: assessment of tissue uptake kinetics (2016) (0)
- Periodic dosage regimens with unequal dosing intervals (1985) (0)
- Fractal structure of the liver: effect on drug elimination (2012) (0)
- Pharmacokinetics and toxicity of idarubicin in the rat (2001) (0)
- Modelling distribution kinetics of drugs in the rat head (2000) (0)
- Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events (2004) (0)
- Board Certified in Gastroenterology (2012) (0)
- Exponential tails of drug disposition curves: Reality or appearance? (2013) (0)
- Beta blockade increases pulmonary and systemic transit time heterogeneity: evaluation based on indocyanine green kinetics in healthy volunteers (2017) (0)
- Addendum to the commentary to “pharmacokinetics from a dynamical systems point of view” (1990) (0)
- Estimation and Model Selection in Pharmacokinetics: The Effect of Model Misspecification (1997) (0)
- On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed (1997) (0)
- Dependence of Bioavailability on Mean Absorption Time: What Does It Tell Us? (2023) (0)
- Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing (2010) (0)
- Hepatocellular Necrosis, Fibrosis and Microsomal Activity Determine the Hepatic Pharmacokinetics of Basic Drugs in Right-Heart-Failure-Induced Liver Damage (2012) (0)
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