Michael Wigler

Q: What Schools Are Affiliated With Michael Wigler

Michael Wigler is affiliated with the following schools: Stony Brook University, University of Michigan, Icahn School of Medicine at Mount Sinai, Princeton University, Cornell University, University of Washington, University of North Carolina at Chapel Hill, University of California, San Francisco, Columbia University, Harvard University

Michael Wigler's AcademicInfluence.com Rankings

Michael Wigler

Biology

#1450

World Rank

#2432

Historical Rank

#724

USA Rank

Molecular Biology

#289

World Rank

#294

Historical Rank

#116

USA Rank

biology Degrees

Download Badge

Biology

Michael Wigler's Degrees

PhD Molecular Biology Cornell University

Why Is Michael Wigler Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Michael Howard Wigler is an American molecular biologist who has directed a laboratory at Cold Spring Harbor Laboratory since 1978 and is a member of the National Academy of Sciences. He is best known for developing methods to genetically engineer animal cells and his contributions to cancer, genomics and autism genetics.

(See a Problem?)

Michael Wigler's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer (1997) (5044)
Strong Association of De Novo Copy Number Mutations with Autism (2007) (2746)
Large-Scale Copy Number Polymorphism in the Human Genome (2004) (2571)
Tumour evolution inferred by single-cell sequencing (2011) (2330)
Circular binary segmentation for the analysis of array-based DNA copy number data. (2004) (2219)
The contribution of de novo coding mutations to autism spectrum disorder (2014) (1988)
Cloning the differences between two complex genomes (1993) (1361)
De Novo Gene Disruptions in Children on the Autistic Spectrum (2012) (1335)
The lipid phosphatase activity of PTEN is critical for its tumor supressor function. (1998) (1208)
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells (1977) (1178)
Transformation of mammalian cells with genes from procaryotes and eucaryotes (1979) (1177)
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach (2006) (1095)
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. (1979) (1063)
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor (1978) (1057)
In yeast, RAS proteins are controlling elements of adenylate cyclase (1985) (1001)
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method (1988) (905)
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. (1997) (819)
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. (2008) (807)
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins (1990) (749)
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (1993) (734)
Multiple ras functions can contribute to mammalian cell transformation (1995) (719)
Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders (2011) (699)
Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses (2011) (669)
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase (1987) (654)
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change (1982) (646)
Complex formation between RAS and RAF and other protein kinases. (1993) (578)
Inferring tumor progression from genomic heterogeneity. (2010) (503)
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae (1987) (496)
Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. (2003) (472)
Structure and activation of the human N-ras gene (1983) (468)
An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer (2008) (451)
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells (1982) (440)
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains (1986) (420)
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway (1987) (419)
Human-tumor-derived cell lines contain common and different transforming genes (1981) (413)
Genetic analysis of yeast RAS1 and RAS2 genes (1984) (397)
Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS (1996) (396)
Genetic and physical linkage of exogenous sequences in transformed cells (1980) (386)
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (2013) (373)
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins (1984) (371)
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase (1985) (369)
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation (1996) (367)
Three human transforming genes are related to the viral ras oncogenes. (1983) (359)
The role of de novo mutations in the genetics of autism spectrum disorders (2014) (352)
Complex synthetic chemical libraries indexed with molecular tags. (1993) (350)
A unified genetic theory for sporadic and inherited autism (2007) (335)
Genome-wide copy number analysis of single cells (2012) (332)
The somatic replication of DNA methylation (1981) (329)
Novel patterns of genome rearrangement and their association with survival in breast cancer. (2006) (322)
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1 (1983) (316)
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells (1978) (310)
Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins (1985) (307)
Tumour promotor induces plasminogen activator (1976) (301)
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs (1993) (296)
Cooperative interaction of S. pombe proteins required for mating and morphogenesis (1994) (293)
RAS proteins can induce meiosis in xenopus oocytes (1985) (288)
Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism (2011) (279)
Functional homology of mammalian and yeast RAS genes (1985) (277)
A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation* (1996) (258)
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. (1994) (257)
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. (2003) (256)
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. (1984) (255)
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. (1986) (252)
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. (1983) (252)
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae (1988) (250)
PTEN controls tumor-induced angiogenesis (2001) (239)
Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein (1990) (236)
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. (2009) (231)
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. (1987) (231)
Signaling pathways in Ras-mediated tumorigenicity and metastasis. (1998) (214)
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor (1986) (211)
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. (1993) (204)
New human transforming genes detected by a tumorigenicity assay (1984) (201)
Expression and rearrangement of the ROS1 gene in human glioblastoma cells. (1987) (200)
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. (1988) (200)
Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae (1991) (198)
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae (1987) (190)
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. (2009) (187)
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. (2008) (186)
byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype (1991) (184)
Interactive analysis and assessment of single-cell copy-number variations (2015) (179)
Comparative genomic analysis of tumors: detection of DNA losses and amplification. (1995) (172)
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity (1993) (169)
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. (1993) (168)
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae (1989) (164)
CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex (1991) (164)
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. (1989) (163)
Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients (2010) (160)
Isolation of the chicken thymidine kinase gene by plasmid rescue (1980) (160)
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. (1995) (157)
A preparative method for obtaining enucleated mammalian cells. (1975) (152)
DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (2002) (146)
Recurrent DNA copy number variation in the laboratory mouse (2007) (144)
Transformation of mammalian cells with an amplifiable dominant-acting gene. (1980) (139)
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell (1980) (135)
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions (2012) (133)
Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells (2014) (133)
Accurate de novo and transmitted indel detection in exome-capture data using microassembly (2014) (133)
Low load for disruptive mutations in autism genes and their biased transmission (2015) (129)
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. (1992) (126)
Genetic analysis of mammalian GAP expressed in yeast (1989) (124)
DNA methylation patterns in luminal breast cancers differ from non‐luminal subtypes and can identify relapse risk independent of other clinical variables (2011) (124)
Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis (1994) (123)
Evaluation of the FHIT gene in colorectal cancers. (1996) (123)
Standardization and Component Analysis (1972) (122)
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. (1977) (120)
Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. (2000) (117)
Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. (1992) (117)
The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease (2013) (114)
Optimizing sparse sequencing of single cells for highly multiplex copy number profiling (2015) (114)
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). (2009) (113)
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. (1992) (109)
Characterization of an activated human ros gene (1986) (107)
Genetic Evidence for Pak1 Autoinhibition and Its Release by Cdc42 (1999) (103)
Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (1991) (103)
Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. (1988) (100)
A method for difference cloning: gene amplification following subtractive hybridization. (1990) (98)
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. (1979) (96)
Indel variant analysis of short-read sequencing data with Scalpel (2015) (96)
The inheritance of methylation patterns in vertebrates (1981) (93)
Genetic analysis using genomic representations. (1998) (93)
DBC2, a candidate for a tumor suppressor gene involved in breast cancer (2002) (91)
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae (1987) (90)
Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. (1990) (90)
Characterization of ROS1 cDNA from a human glioblastoma cell line. (1990) (88)
Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. (1991) (85)
The adenylyl cyclase gene from Schizosaccharomyces pombe. (1989) (85)
Annotating large genomes with exact word matches. (2003) (84)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (84)
Multiple regulatory domains on the Byr2 protein kinase (1997) (83)
Purification and characterization of human H-ras proteins expressed in Escherichia coli (1985) (81)
Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe (1994) (78)
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe (1996) (76)
Representational difference analysis in detection of genetic lesions in cancer. (1995) (72)
Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA (2015) (71)
The ras oncoprotein and M-phase activity. (1991) (71)
A product of yeast RAS2 gene is a guanine nucleotide binding protein. (1984) (70)
A versatile statistical analysis algorithm to detect genome copy number variation. (2004) (69)
Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes. (2020) (67)
Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. (1978) (65)
Transformation of Mammalian Cells (1979) (64)
Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. (1992) (63)
Studies of RAS function in the yeast Saccharomyces cerevisiae. (1988) (61)
Accurate detection of de novo and transmitted indels within exome-capture data using micro-assembly (2014) (60)
Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. (1983) (58)
Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. (1993) (58)
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. (2001) (57)
Identification of alterations in DNA copy number in host stromal cells during tumor progression (2006) (55)
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. (1991) (52)
GAPs in understanding Ras (1990) (52)
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor (2001) (52)
Two types of RAS mutants that dominantly interfere with activators of RAS (1994) (51)
Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. (1987) (49)
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. (1988) (48)
A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe. (1992) (47)
Chromosomal assignment of a family of human oncogenes. (1983) (46)
Damaging de novo mutations diminish motor skills in children on the autism spectrum (2018) (46)
Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. (1990) (45)
Copy-number variants in patients with a strong family history of pancreatic cancer (2007) (42)
Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. (2020) (41)
Cell culture studies provide new information on tumour promoters (1977) (41)
Glucocorticoid inhibition of the fibrinolytic activity of tumor cells (1975) (39)
A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. (1990) (38)
Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization. (1987) (37)
Mutants of H‐ras that interfere with RAS effector function in Saccharomyces cerevisiae. (1989) (37)
Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements (2005) (36)
Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing (2020) (36)
Characterization of the ros1-gene products expressed in human glioblastoma cell lines. (1989) (33)
PROBER: oligonucleotide FISH probe design software (2006) (30)
Biological activity of the mammalian RAP genes in yeast. (1990) (30)
Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins (1995) (30)
Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. (1999) (29)
Nucleosomes in metaphase chromosomes. (1976) (28)
Human Sos 1 : A Guanine Nucleotide Exchange Factor for Ras That Binds to GRB 2 (2012) (27)
Distribution of short paired duplications in mammalian genomes. (2004) (27)
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. (2006) (25)
Linkage and expression of foreign DNA in cultured animal cells. (1981) (25)
Ras partners. (1994) (24)
Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer. (2018) (24)
Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. (1987) (24)
Rare de novo germline copy-number variation in testicular cancer. (2012) (21)
SMASH, a fragmentation and sequencing method for genomic copy number analysis (2016) (18)
Detection of genetic loss in tumors by representational difference analysis. (1994) (16)
Correction: Corrigendum: Genome-wide copy number analysis of single cells (2016) (15)
High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. (2005) (15)
Target inference from collections of genomic intervals (2013) (14)
Broad applications of single-cell nucleic acid analysis in biomedical research (2012) (13)
High resolution representational oligonucleotide microarray analysis (ROMA) suggests that TOPO2 and HER2 co-amplification is uncommon in human breast cancer. (2009) (13)
A test of the role of two oncogenes in inherited predisposition to colon cancer. (1983) (12)
Reducing system noise in copy number data using principal components of self-self hybridizations (2011) (12)
The cancer stem cell: Cell type or cell state? (2013) (12)
The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. (1991) (11)
Mutational analysis of the cloned chicken thymidine kinase gene. (1983) (11)
Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. (1986) (10)
Quantitative Multigene FISH on Breast Carcinomas Identifies der(1;16)(q10;p10) as an Early Event in Luminal A Tumors (2014) (10)
Rates of contributory de novo mutation in high and low-risk autism families (2021) (10)
Placing Probes along the Genome Using Pairwise Distance Data (2001) (9)
Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal. (2017) (9)
Validation of S. Pombe Sequence Assembly by Microarray Hybridization (2006) (8)
MUMdex: MUM-based structural variation detection (2016) (8)
A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes. (2003) (8)
Wild by Nature (2002) (8)
Structure and Activation of Ras Genes (1984) (7)
A Sense of Life ∗ (2003) (7)
Facilitated sequence counting and assembly by template mutagenesis (2014) (7)
Interactive analysis and quality assessment of single-cell copy-number variations (2014) (7)
Rapid isolation of cDNA by hybridization. (1998) (6)
Partial bisulfite conversion for unique template sequencing (2017) (6)
Oncoproteins. GAPs in understanding Ras. (1990) (6)
Copolymerization of single-cell nucleic acids into balls of acrylamide gel (2019) (6)
Preparation of target DNA (2003) (6)
Enucleation of mammalian cells in suspension. (1976) (5)
RAS function and protein kinase cascades. (1993) (5)
Measuring shared variants in cohorts of discordant siblings with applications to autism (2017) (5)
TRANSFORMATION OF MAMMALIAN CELLS WITH PROKARYOTIC AND EUKARYOTIC GENES (1979) (5)
Conservation and divergence of RAS protein function during evolution. (1985) (5)
Removing System Noise from Comparative Genomic Hybridization Data by Self-Self Analysis (2011) (4)
Characterization of two new human oncogenes. (1986) (4)
DNA Mediated Gene Transfer: Theory and Application (1980) (4)
capture and single molecule bisulfite sequencing High definition profiling of mammalian DNA methylation by array Material Supplemental (2009) (4)
Sari , a gene from Schizosaccharomyces pombe encoding a protein that regulates rasl (2003) (4)
De novo indels within introns contribute to ASD incidence (2017) (3)
Integrated Computational Pipeline for Single-Cell Genomic Profiling (2020) (3)
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. United States Patent 4634665 (1987) (3)
MECHANISMS OF DNA-MEDIATED TRANSFORMATION IN ANIMAL CELLS (1980) (3)
Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancer (2019) (3)
cause tumorigenic transformation . kinase-independent pathways is sufficient to Raf / mitogen-activated protein Oncogenic Ras activation of (1996) (3)
Preparation of slides and hybridization (2003) (3)
produces two neurofibromin isoforms , both of Recklinghausen neurofibromatosis ( NF 1 ) gene A conserved alternative splice in the von (1992) (2)
which have GTPase-activating protein activity. produces two neurofibromin isoforms, both of Recklinghausen neurofibromatosis (NF1) gene A conserved alternative splice in the von (2012) (2)
Alternative Splicing in the Proposed Catalytic Domain of the Type-1 Neurofibromatosis Gene (1991) (2)
Saccharomyces cerevisiae . cyclic AMP phosphodiesterase gene of Cloning and characterization of the low-affinity (2)
Activation of the Human H-Ras Gene (1983) (2)
Multiplex accurate sensitive quantitation (MASQ) with application to minimal residual disease in acute myeloid leukemia (2020) (2)
DNA construct for producing proteinaceous materials in eucaryotic cells. United States Patent 6455275 (2002) (2)
Accurate measurement of microsatellite length by disrupting its tandem repeat structure (2021) (1)
potential targets for antidepressant drugs. gene product of Drosophila melanogaster are memory homologous to the dunce learning and A family of human phosphodiesterases (2012) (1)
Broad applications of single-cell nucleic acid analysis in biomedical research (2012) (1)
Genomic heterogeneity of circulating tumor cells in castration-resistant prostate cancer (CRPC) revealed by single-cell sequencing. (2013) (1)
Use of DNA Polymorphisms to Establish the Linkage Map of the Pth, Beta-Globin, C-Ha-Ras-1, and Insulin Loci on 11p (1984) (1)
The adenylyl cyclase gene from Schizosaccharomyces pombe ( signal transduction / cAMP / evolution / ceil regulation ) (1)
The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease (2013) (1)
Function of Yeast Ras Genes (1985) (1)
Detection of gene copy number fluctuations with microarrays using genomic representations (2001) (1)
Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces (1985) (1)
Genetic Analysis of Human Breast Cancer. (1995) (1)
1005 High resolution microarray copy number analysis (array CGH) suggests that determination of HER2 amplification by FISH (FISH+) is inaccurate in human breast cancer specimens that are HER2 2+ by immunohistochemistry (IHC2+) (2009) (1)
Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA. (1978) (1)
cerevisiae . activation of wild-type RAS in Saccharomyces that interfere with the CDC 25-dependent Dominant yeast and mammalian RAS mutants (1)
A Family ofHumanPhosphodiesterases Homologous tothedunce Learning andMemoryGeneProduct ofDrosophila melanogaster ArePotential Targets forAntidepressant Drugs (1993) (1)
RareDeNovoandTransmittedCopy-NumberVariation in Autistic Spectrum Disorders (2011) (1)
G-Graph: An interactive genomic graph viewer (2019) (1)
protein kinase . Multiple regulatory domains on the Byr 2 (1997) (1)
INDUCTION OF OOCYTE MATURATION BY INJECTION OF ONCOGENIC H-ras PROTEIN IN THE STARFISH : Developmental Biology (1986) (1)
New polymorphic markers in the vicinity of the pearl locus on mouse Chromosome 13 (2009) (1)
Abstracts of papers presented at the LIII Cold Spring Harbor Symposium on Quantitative Biology : the Molecular Biology of Signal Transduction, May 25-June 1, 1988 (1988) (1)
Targeted de novo phasing and long-range assembly by template mutagenesis (2022) (1)
Shkl , a homolog of the Saccharomyces cerevisiae Ste 2 O and mammalian p 65 PAK protein kinases , is a component of a Ras / Cdc 42 signaling module in the fission yeast Schizosaccharomyces pombe (2005) (1)
Heteroplasmy is ubiquitous and stable at the single cell level (2014) (1)
Identification, Isolation, and Characterization of Human Transforming Genes (1983) (1)
Mito-seek enables deep analysis of mitochondrial DNA, revealing ubiquitous, stable heteroplasmy maintained by intercellular exchange (2014) (1)
Damaging Mutations are Associated with Diminished Motor Skills and IQ in Children on the Autism Spectrum (2017) (1)
Cloning by complementation and related processes. United States Patent 5977305 (1999) (0)
Human Transforming Genes (1983) (0)
Complex combinatorial chemical libraries encoded with tags. United States Patent 6503759 (2003) (0)
"RAS Function in Yeast and Humans" : Signal transduction and cell cycle : (S-9) (1996) (0)
O PREDICTION OF AXILLARY STATUS FROM SENTINEL LYMPH NODE TESTING WITH AN INTRAOPERATIVE RT-PCR TEST – MULTI-CENTER ANALYSIS OF 1138 PATIENTS (2009) (0)
Author response: Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing (2020) (0)
Schizosaccharomyces pombe. Byr2 in the sexual response pathway of Identification of Ste4 as a potential regulator of (2012) (0)
suppression of the ras1 mutant phenotype. encoding a protein kinase capable of partial byr2, a Schizosaccharomyces pombe gene (2012) (0)
ONCOGENES Structure and Activation of Mammalian ras Genes (2013) (0)
J Field complex . Saccharomyces cerevisiae adenylyl cyclase CAP is a bifunctional component of the (2004) (0)
DNA sequence encoding mas onhcogene, polypeptides encoded therefrom and diagnostic and other methods based therefrom. United States Patent 5320941 (1994) (0)
Methods for producing probes capable of distinguishing DNA from related sources. United States Patent 6159713 (2000) (0)
Genome-Wide DNA Methylation Profiles of Breast Tumors Reveal Loci Associated with Relapse Risk. (2009) (0)
Genetic andbiochemical analysis oftheadenylyl cyclase ofSchizosaccharomyces (1991) (0)
Characterization of an activated human ros (0)
Methods for recording the reaction history of a solid support. United States Patent 5968736 (1996) (0)
Integration of Ras and Adenylate Cyclase Pathways in Yeast (1988) (0)
Tracing Tumor Lineage and Progression through Genomic Copy Number Profiling at the Single Cell Level (2010) (0)
Whole Genome Sequencing Comparison of Acute Myeloid Leukemia at Presentation and Remission Predicts Patient Outcome (2022) (0)
Simple genetic models for autism spectrum disorder (2015) (0)
High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL. (2008) (0)
Conservation of Ste20-Related Protein-Kinases in Eukaryotes (1994) (0)
Schizosaccharomyces pombe . sexual response pathways of Concerted action of RAS and G proteins in the (0)
Use of representations of DNA for genetic analysis. United States Patent 8663917 (2014) (0)
A product of yeast RAS 2 gene is a guanine nucleotide binding protein ( oncogenes / evolution ) (0)
Control of Yeast Adenyl-Cyclase by Ras Proteins (1985) (0)
Abstracts of papers presented at the LIV Cold Spring Harbor Symposium on Quantitative Biology : immunological recognition, May 31-June 7, 1989 (1989) (0)
Identification Isolation and Characterization of 3 Distinct Human Transforming Genes (1983) (0)
Roleof26SProteasome andHRD Genesinthe Degradation of3-Hydroxy-3-Methylglutaryl-CoA Reductase, anIntegral Endoplasmic Reticulum MembraneProtein (1996) (0)
Microinjection of Ras Oncogene Proteins and Inhibitory Antibodies Specific for the Ras Oncogene Proteins into Living Normal and Transformed-Cells (1985) (0)
A representative treatment by DNA analysis (1993) (0)
Nucleic Acids Research Nucleosomes in metaphase chromosomes (0)
Bioassay for transforming genes and genes detected thereby.United States Patent 4866166 (1989) (0)
The Ways of Ras (1991) (0)
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. United States Patent 6479243 (1998) (0)
Complex combinatorial chemical libraries encoded with tags. United States Patent 5721099 (1998) (0)
584 Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma (2012) (0)
A RoleforAutophosphorylation Revealed byActivated Alleles ofFUS3,theYeast MAP Kinase Homolog (1994) (0)
in vivo Analysis of C-Raf1 — 14-3-3 Interaction (1997) (0)
Methods for producing probes capable of distingushing variant genomic sequences. United States Patent 5436142 (1995) (0)
Complex combinatorial chemical libraries encoded signals. (1993) (0)
Subtype Dependent Alterations of the DNA Methylation Landscape in Breast Cancer. (2009) (0)
Classification method for microarray probe selection using sequence, thermodynamics and secondary structure parameters (2008) (0)
Comparative genomic analysis of tumors: Detection of DNA losses (2005) (0)
Title New polymorphic markers in the vicinity of the pearl locus on mouse Chromosome 13 Permalink (2009) (0)
Abstracts of papers presented at the 1990 Meeting on Function and Evolution of RAS Proteins, May 9-May 13, 1990 (1990) (0)
Macrocyclic Plant Diterpene Esters and Other Agents Related Induction of Plasminogen Activator in Cultured Cells by (2006) (0)
Talk from Mike Wigler at the Cold Spring Harbor Laboratory In-House Symposium (2011) (2011) (0)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (0)
Methods for identifying modulators of gene expression. United States Patent 6569617 (2003) (0)
Assessment of schizophrenia genomes for DNA copy number alterations (2005) (0)
to Tumor Promotion Macrocyclic Plant Diterpene Esters and Other Agents Related Induction of Plasminogen Activator in Cultured Cells by Updated (2006) (0)
Stable heteroplasmy at the single cell level is facilitated by inter-cellular exchange of mtDNA (2014) (0)
COPY NUMBER VARIATION AND GENETIC DRIFT IN THE INBRED MOUSE (2006) (0)
tumorigenicity assay. New human transforming genes detected by a (2012) (0)
Identification Isolation and Preliminary Characterization of 3 Human Transforming Genes (1984) (0)
Isolation and Characterization of Genes That Regulate Ras Function in the Yeast Saccharomyces-Cerevisiae (1990) (0)
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae ( heat shock / yeast RAS 2 VIl 9 gene / suppressor / PDE 2 gene ) (0)
Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins (1987) (0)
and Its Release by Cdc 42 Genetic Evidence for Pak 1 Autoinhibition (1998) (0)
Methods for producing probes capable of distinguishing DNA from related sources. United States Patent 5501964 (1996) (0)
A representative treatment of the dns-analysis (1993) (0)
Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance (1990) (0)
Cancer detection probes. United States Patent 6350576 (2002) (0)
Cloning of mammalian genes in microbial organisms and methods for pharmacological screening. United States Patent 6080540 (2000) (0)
Mutational sequencing for accurate count and long-range assembly (2017) (0)
Construction of Co Transformation of Human Cell Lines Which Express Segments of the Adenovirus Genome (1980) (0)
Tropomyosin-2 cDNA Lacking the3'Untranslated RegionRiboregulator Induces GrowthInhibition of v-Ki-ras-transfo rmed Fibroblasts (1997) (0)
Molecular subclassification of breast carcinomas based on aCGH reveals two major groups of tumors with common genomic, transcriptomic and clinicopathological characteristics (2009) (0)
Structures of 3 Ras Genes Activated in Human-Tumor Cell-Lines (1983) (0)
Evolution of Ras Signal Transduction Pathways (1993) (0)
Application of representational microarrays to genetic analysis of primary tumours (1999) (0)
Rates of contributory de novo mutation in high and low-risk autism families (2021) (0)
The Last Ten Yards (2013) (0)
Molecular Markers for Prostate Cancer Risk Stratification from Multiple Ultrasound-Guided Biopsies (2014) (0)
Cloning by complementation and related processes. United States Patent 5527896 (1996) (0)
Cancer detection probes. United States Patent 5569753 (1996) (0)
Cloning by complementation and related processes. United States Patent 6069240 (2000) (0)
Growth Control in S . cerevisiae (2013) (0)
Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags. United States Patent 6001579 (1999) (0)
Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase (1990) (0)
Complex combinatorial chemical libraries encoded with tags. United States Patent 5565324 (1996) (0)
Representational approach to DNA analysis. United States Patent 6277606 (2001) (0)
Saccharomyces cerevisiae. competition between, RAS proteins from Guanine nucleotide activation of, and (2012) (0)
gene. of an activated human ros (2012) (0)
Representational approach to DNA analysis. United States Patent 5876929 (1996) (0)
varietal count nucleic acids for information on the number of genomic copies (2011) (0)
The Ras Signalling Pathway in Yeast (1991) (0)
Isolation and Characterization of a Previously Undetected Human cAMP Phosphodiesterase by Complementation of CAMP Phosphodiesterase-deficient Saccharomyces cereuisiae " (2001) (0)
Genome Analysis of CLL by Representational Oligonucleotide Microarray Analysis (ROMA) (2006) (0)
High Resolution Comparative Genomic Hybridization (CGH) Indicates That Genomic Profiles Are Very Heterogeneous for HER2 and TOP2A in FISH-Amplified Human Breast Cancer Specimens. (2009) (0)
Use of representations of DNA for genetic analysis. United States Patent 7531307 (2009) (0)
Ras proteins. membrane attachment and palmitoylation of cerevisiae suppress Ras function and block Mutations in the SHR5 gene of Saccharomyces (2012) (0)
Probe arrays, and methods of using the probe arrays to discriminate between DNA (1998) (0)
Crystal structure of Ras-Bry2RBD complex (2002) (0)
High Resolution Analysis of Copy Number Mutation in Breast Cancer (2005) (0)
High-resolution analysis of genome copy number variation in autism (2006) (0)
Topo2a and Her2 Co-Amplification Is Uncommon by High Resolution Representational Oligonucleotide Microarray Analysis (Roma) in Human Breast Cancer (2009) (0)
A gene from Schizosaccharomyces-Pombe with homology to Escherichia-Coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells (1990) (0)
Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations. United States Patent 8554488 (2013) (0)
Cold Spring Harbor Laboratory Annual Reports Excerpts: Wigler Laboratory 1979-2011 (2013) (0)
High-resolution representational oligonucleotide microarray analysis and fluorescence in situ hybridization analysis of aneuploid and diploid breast tumors (2005) (0)
regulation Myc enhancer-mediated Role of SWI / SNF in acute leukemia maintenance and Material Supplemental (2013) (0)
Molecular subclassification of breast carcinomas based on aCGH, gene expression, IHC and ploidy - relevance for clinical outcome (2008) (0)
Alterations in chromosome organization and structure (2006) (0)

This paper list is powered by the following services:

Other Resources About Michael Wigler

en.wikipedia.org

What Schools Are Affiliated With Michael Wigler?

Michael Wigler is affiliated with the following schools:

Michael Wigler's Academic­Influence.com Rankings