Michel Bouvier
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Molecular Biology
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Neuroscience
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Biochemistry
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Biology
Michel Bouvier's Degrees
- PhD Biochemistry Université de Montréal
- Masters Biochemistry Université de Montréal
- Bachelors Biochemistry Université de Montréal
Why Is Michel Bouvier Influential?
(Suggest an Edit or Addition)Michel Bouvier's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation* (1996) (791)
- Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). (2000) (694)
- Roles of G‐protein‐coupled receptor dimerization (2004) (689)
- Oligomerization of G-protein-coupled transmitter receptors (2001) (675)
- Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. (2002) (603)
- Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. (2000) (536)
- Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. (1989) (525)
- Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation (1987) (485)
- β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors (2003) (459)
- Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. (2005) (455)
- Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer* (2002) (449)
- Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes (2006) (428)
- Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization (2003) (427)
- Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization (1988) (419)
- Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. (1989) (394)
- GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling (2016) (390)
- Real-time monitoring of receptor and G-protein interactions in living cells (2005) (389)
- Building a new conceptual framework for receptor heteromers. (2009) (376)
- The evasive nature of drug efficacy: implications for drug discovery. (2007) (359)
- Inverse agonist activity of beta-adrenergic antagonists. (1994) (358)
- Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. (1988) (347)
- Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting* (2004) (322)
- Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. (2003) (319)
- Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer* 210 (2002) (312)
- Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor* (2000) (309)
- International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers (2007) (299)
- Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy (2006) (292)
- Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity (2005) (280)
- Ligands act as pharmacological chaperones and increase the efficiency of δ opioid receptor maturation (2002) (278)
- Pharmacological chaperones: potential treatment for conformational diseases (2004) (275)
- Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers* (2005) (273)
- Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling* (2010) (267)
- Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study (2002) (266)
- Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function. (2003) (264)
- The experimental power of FR900359 to study Gq-regulated biological processes (2015) (251)
- Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis (2017) (248)
- Restructuring G-Protein- Coupled Receptor Activation (2012) (248)
- Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. (1989) (243)
- Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. (2002) (238)
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region (2016) (232)
- Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors* 210 (2002) (231)
- Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus. (2005) (229)
- Structural and functional aspects of G protein-coupled receptor oligomerization. (1998) (229)
- Pharmacological chaperones: a new twist on receptor folding. (2000) (226)
- Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome* (2001) (222)
- Methods to monitor the quaternary structure of G protein‐coupled receptors (2005) (221)
- Propranolol therapy for ectopic beta-adrenergic receptors in adrenal Cushing's syndrome. (1997) (211)
- β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy* (2002) (208)
- G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase* (2002) (200)
- Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy (2014) (200)
- Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. (2003) (191)
- Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor. (1994) (191)
- cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. (1989) (187)
- Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization (2004) (181)
- Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET (2016) (178)
- Cardiac adrenergic receptor effects of carvedilol. (1996) (178)
- Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer (2003) (178)
- High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay (2005) (176)
- Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. (1987) (175)
- Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo (2007) (174)
- Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET (2005) (171)
- The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization. (1993) (169)
- Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. (2004) (166)
- The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. (1987) (165)
- Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells. (1992) (161)
- Altered phosphorylation and desensitization patterns of a human beta 2‐adrenergic receptor lacking the palmitoylated Cys341. (1993) (155)
- Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059. (2004) (154)
- Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)* (2011) (153)
- Real-time monitoring of ubiquitination in living cells by BRET (2004) (146)
- Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells (2006) (146)
- Hetero-oligomerization between β2- and β3-Adrenergic Receptors Generates a β-Adrenergic Signaling Unit with Distinct Functional Properties* (2004) (146)
- Resonance energy transfer approaches in molecular pharmacology and beyond. (2007) (145)
- Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 (2018) (143)
- Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs (2012) (143)
- Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. (2004) (142)
- Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. (1993) (142)
- A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells (2011) (140)
- Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes* (2011) (137)
- Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization (2013) (135)
- Functional Significance of Oligomerization of G-protein-coupled Receptors (2000) (135)
- Agonist-promoted Internalization of a Ternary Complex between Calcitonin Receptor-like Receptor, Receptor Activity-modifying Protein 1 (RAMP1), and β-Arrestin* (2001) (132)
- Phosphorylation‐independent desensitization of GABAB receptor by GRK4 (2003) (130)
- Pharmacological chaperone action on G-protein-coupled receptors. (2004) (128)
- Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein (2013) (127)
- THE BRET2/ARRESTIN ASSAY IN STABLE RECOMBINANT CELLS: A PLATFORM TO SCREEN FOR COMPOUNDS THAT INTERACT WITH G PROTEIN-COUPLED RECEPTORS (GPCRS)* (2002) (125)
- Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins* (2008) (121)
- Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction. (2008) (120)
- Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding (2017) (119)
- Receptor activity‐independent recruitment of βarrestin2 reveals specific signalling modes (2004) (119)
- Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus. (2001) (114)
- Protein-Protein Interaction and Not Glycosylation Determines the Binding Selectivity of Heterodimers between the Calcitonin Receptor-like Receptor and the Receptor Activity-modifying Proteins* (2001) (113)
- Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands (2009) (113)
- How sacral nerve stimulation works in patients with faecal incontinence (2011) (112)
- Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog. (1991) (110)
- Palmitoylated Cysteine 341 Modulates Phosphorylation of the β2-Adrenergic Receptor by the cAMP-dependent Protein Kinase* (1996) (110)
- Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (2018) (109)
- Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways (2009) (106)
- Manometric and radiologic investigations and biofeedback treatment of chronic idiopathic anal pain (1991) (105)
- Agonist-induced modulation of inverse agonist efficacy at the beta 2-adrenergic receptor. (1996) (105)
- Extrinsic nervous control of motility of small and large intestines and related sphincters. (1987) (103)
- Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the β1-Adrenergic Receptor (2008) (101)
- Monitoring Protein‐Protein Interactions in Living Cells by Bioluminescence Resonance Energy Transfer (BRET) (2006) (101)
- Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis. (1999) (101)
- BRET analysis of GPCR oligomerization: newer does not mean better (2007) (99)
- Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts. (1992) (99)
- A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling (2017) (99)
- Distinct Subcellular Localization for Constitutive and Agonist-modulated Palmitoylation of the Human δ Opioid Receptor* (2006) (96)
- Heterodimerization of β1- and β2-Adrenergic Receptor Subtypes Optimizes β-Adrenergic Modulation of Cardiac Contractility (2005) (96)
- Insights into signaling from the beta2-adrenergic receptor structure. (2008) (96)
- Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy. (2002) (95)
- Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles (2012) (93)
- A Pluridimensional View of Biased Agonism (2016) (93)
- Molecular and Cellular Physiology of Apolipoprotein A-I Lipidation by the ATP-binding Cassette Transporter A1 (ABCA1)* (2004) (93)
- Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. (1990) (92)
- Transcutaneous Electrical Tibial Nerve Stimulation in the Treatment of Fecal Incontinence: A Randomized Trial (Consort 1a) (2012) (91)
- A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway* (2010) (90)
- Nitric Oxide Modulates β2-Adrenergic Receptor Palmitoylation and Signaling* (1999) (90)
- Unraveling G Protein-coupled Receptor Endocytosis Pathways Using Real-time Monitoring of Agonist-promoted Interaction between β-Arrestins and AP-2* (2007) (90)
- Homo- and Hetero-oligomerization of β-Arrestins in Living Cells* (2005) (89)
- Functional rescue of a constitutively desensitized beta2AR through receptor dimerization. (1998) (88)
- Phosphorylation of the rev gene product of human immunodeficiency virus type 1 (1988) (88)
- Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity (2010) (87)
- Nervous control of the internal anal sphincter of the cat. (1981) (87)
- Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation* (2003) (85)
- Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1* (2007) (85)
- Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors (2018) (84)
- Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation. (1996) (83)
- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base (2010) (82)
- Effects of Consumptionof a Milk Fermented by the Probiotic Strain Bifidobacterium animalis DN-173 010 on Colonic Transit Times in Healthy Humans (2001) (81)
- Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization. (1995) (81)
- The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling. (2007) (80)
- New molecular and structural determinants involved in beta 2-adrenergic receptor desensitization and sequestration. Delineation using chimeric beta 3/beta 2-adrenergic receptors. (1996) (79)
- β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1* (2015) (76)
- Multiplexing of multicolor bioluminescence resonance energy transfer. (2010) (76)
- Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties. (2004) (76)
- Functional Rescue of β1‐Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones (2009) (76)
- Palmitoylation: a post-translational modification that regulates signalling from G-protein coupled receptors. (1996) (75)
- Recovery of homogeneous and functional β2-adrenergic receptors from extracellular baculovirus particles (1997) (74)
- Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer. (2008) (73)
- Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy (2017) (73)
- Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. (1995) (72)
- Characterization of Oligomeric Human ATP Binding Cassette Transporter A1 (2004) (71)
- Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells. (2001) (69)
- Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors (2011) (68)
- Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. (1989) (68)
- Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. (1988) (68)
- Sacral Nerve Stimulation can Improve Continence in Patients with Crohn’s Disease with Internal and External Anal Sphincter Disruption (2008) (67)
- Functional Characterization of Vasopressin Type 2 Receptor Substitutions (R137H/C/L) Leading to Nephrogenic Diabetes Insipidus and Nephrogenic Syndrome of Inappropriate Antidiuresis: Implications for Treatments (2010) (65)
- Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons (2019) (63)
- How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling (2020) (63)
- Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling (2006) (62)
- Oligomerization of Transcriptional Intermediary Factor 1 Regulators and Interaction with ZNF74 Nuclear Matrix Protein Revealed by Bioluminescence Resonance Energy Transfer in Living Cells* (2003) (61)
- Development and Characterization of Pepducins as Gs-biased Allosteric Agonists*♦ (2014) (61)
- Systematic protein–protein interaction mapping for clinically relevant human GPCRs (2017) (60)
- Dynamic anal endosonography may challenge defecography for assessing dynamic anorectal disorders: results of a prospective pilot study. (2000) (60)
- Dynamic Anal Endosonography and MRI Defecography in Diagnosis of Pelvic Floor Disorders: Comparison With Conventional Defecography (2011) (57)
- Effects of leptin on cat intestinal vagal mechanoreceptors (2002) (57)
- Mutation of tyrosine‐141 inhibits insulin‐promoted tyrosine phosphorylation and increased responsiveness of the human beta 2‐adrenergic receptor. (1995) (57)
- Multimerization of Staufen1 in live cells. (2010) (56)
- CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers (2014) (56)
- The palmitoylation state of the β2‐adrenergic receptor regulates the synergistic action of cyclic AMP‐dependent protein kinase and β‐adrenergic receptor kinase involved in its phosphorylation and desensitization (2001) (56)
- Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets (2016) (55)
- Functional characterization of a novel serotonin receptor (5‐HTap2) expressed in the CNS of Aplysia californica (2002) (55)
- Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine* (2014) (54)
- Cell-specific down-regulation of the beta 3-adrenergic receptor. (1994) (54)
- Monitoring G protein-coupled receptor and b-arrestin trafficking in live cells using enhanced bystander (2016) (54)
- Bioluminescence resonance energy transfer–based imaging of protein–protein interactions in living cells (2019) (53)
- Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity (2017) (52)
- Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics (2020) (52)
- An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling (2010) (52)
- Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences. (1995) (52)
- Subcellular distribution of GABA(B) receptor homo- and hetero-dimers. (2005) (51)
- Biochemical Characterization of β2-Adrenergic Receptor Dimers and Oligomers (2003) (50)
- 3D High‐definition anorectal manometry: Values obtained in asymptomatic volunteers, fecal incontinence and chronic constipation. Results of a prospective multicenter study (NOMAD) (2017) (50)
- Characterization, expression, and hormonal control of a thymic beta 2-adrenergic receptor. (1994) (50)
- Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy (2006) (50)
- CNIH4 Interacts with Newly Synthesized GPCR and Controls Their Export from the Endoplasmic Reticulum (2014) (49)
- Phorbol‐ester‐induced phosphorylation of the β2‐adrenergic receptor decreases its coupling to Gs (1991) (48)
- Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base (2007) (48)
- Homo- and hetero-oligomerization of beta-arrestins in living cells. (2005) (47)
- Conformational Dynamics of Kir3.1/Kir3.2 Channel Activation Via δ-Opioid Receptors (2013) (47)
- Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. (1990) (47)
- Activation of the β2-Adrenergic Receptor-Gαs Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and Gαs * (1999) (47)
- Expression, regulation, and activity of ABCA1 in human cell lines. (2003) (46)
- Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus (2009) (46)
- Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility. (2005) (46)
- Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD. (2012) (45)
- Bioinactive ACTH causing glucocorticoid deficiency. (2013) (45)
- Impact of high-level sport practice on anal incontinence in a healthy young female population. (2011) (45)
- Comparison of three‐dimensional high‐resolution manometry and endoanal ultrasound in the diagnosis of anal sphincter defects (2013) (44)
- Electrical activity from smooth muscle of the anal sphincteric area of the cat. (1981) (43)
- Cross‐Talk between Second Messengers (1990) (43)
- Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction (2016) (43)
- Regulation of the AGS3·Gαi Signaling Complex by a Seven-transmembrane Span Receptor* (2010) (43)
- G protein–coupled receptor modulation with pepducins: moving closer to the clinic (2011) (42)
- Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling (2018) (42)
- Receptor-regulated Interaction of Activator of G-protein Signaling-4 and Gαi* (2010) (41)
- Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells (2017) (41)
- The chemokine CXC4 and CC2 receptors form homo‐ and heterooligomers that can engage their signaling G‐protein effectors and βarrestin (2014) (41)
- Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling. (2006) (41)
- Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. (2017) (41)
- PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades (2011) (40)
- Contribution of Kv1.2 Voltage-gated Potassium Channel to D2 Autoreceptor Regulation of Axonal Dopamine Overflow* (2011) (40)
- Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation (2012) (40)
- GPCR activation mechanisms across classes and macro/microscales (2021) (40)
- Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function. (1995) (40)
- Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression (2015) (39)
- FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs (2018) (39)
- Distinct Motifs of Neuropeptide Y Receptors Differentially Regulate Trafficking and Desensitization (2008) (38)
- Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET. (2007) (38)
- Colonosphincteric electromyographic responses to sacral root stimulation: evidence for a somatosympathetic reflex (2008) (38)
- Neuronally mediated interactions between urinary bladder and internal anal sphincter motility in the cat. (1984) (38)
- Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors. (1996) (37)
- The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets (2002) (37)
- Anal endosonography for assessment of anal incontinence with a linear probe: relationships with clinical and manometric features (2002) (36)
- EFFECTS OF ENKEPHALINS AND MORPHINE ON SPONTANEOUS ELECTRICAL ACTIVITY AND ON JUNCTION POTENTIALS ELICITED BY PARASYMPATHETIC NERVE STIMULATION IN CAT AND RABBIT COLON (1982) (36)
- A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer (2005) (36)
- Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs (2022) (36)
- Water‐perfused manometry vs three‐dimensional high‐resolution manometry: a comparative study on a large patient population with anorectal disorders (2013) (36)
- Expression and recovery of functional G-protein-coupled receptors using baculovirus expression systems. (1998) (36)
- Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs (2019) (35)
- Translating biased signaling in the ghrelin receptor system into differential in vivo functions (2018) (35)
- Chemogenetics defines receptor-mediated functions of short chain free fatty acids (2019) (34)
- Allosteric effects of G protein overexpression on the binding of beta-adrenergic ligands with distinct inverse efficacies. (2001) (34)
- A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein* (2004) (34)
- Community guidelines for GPCR ligand bias: IUPHAR review 32 (2022) (33)
- Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment (2019) (32)
- Protein‐protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer (2010) (31)
- Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion (2018) (31)
- Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2 (2014) (31)
- Treatments of faecal incontinence: recommendations from the French National Society of Coloproctology (2014) (31)
- Molecular biology of adrenergic receptors. (1988) (30)
- Primary sequence requirements for S‐acylation of β2‐adrenergic receptor peptides (2001) (30)
- Src-dependent phosphorylation of β2-adaptin dissociates the β-arrestin–AP-2 complex (2007) (30)
- Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells. (1995) (30)
- Functional effects of long‐term activation on human β2‐ and β3‐adrenoceptor signalling (1995) (30)
- Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling. (2021) (29)
- Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors. (2018) (29)
- Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform (2020) (29)
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- Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation (2021) (1)
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- Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys (2020) (1)
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- Les métropoles et la construction d' un "ordre des autonomies relatives" (2015) (0)
- Iconography : L'allergie alimentaire et digestive chez l'adulte (2008) (0)
- La territorialité de l'impôt: un analyseur des mutations des systèmes fiscaux (2019) (0)
- Un monde en mutation, une comptabilité publique en transition (2016) (0)
- L'introduction de la "règle d'or" budgétaire dans la Constitution (2011) (0)
- Considérations sur la manière de parler de l'amour-propre afin d'en bien juger (1992) (0)
- L'expertise medicale dans le droit de la sécurite sociale (2013) (0)
- Avec pierre jean jouve (2006) (0)
- La " règle d' or " des finances publiques a-t-elle un avenir ? (2012) (0)
- Le contrôle fiscal en France: organisation et procedures (2004) (0)
- Les carrières de kaolin d'Hostun, cent vingt ans d'exploitation (2007) (0)
- Assemblage oligomérique des récepteurs couplés aux protéines G (2008) (0)
- 5. L’église (2000) (0)
- Peptides et composes peptidomimetiques affectant l'activite des recepteurs couples a la proteine g par modification de l'oligomerisation des recepteurs (1997) (0)
- The Last Command: Hollywood, lieu du crépuscule (1984) (0)
- La rsponsabilité financière publique confrontée à un système budgétaire en transition (2017) (0)
- Le cadre de l'intervention financière publique s'est transformé (2006) (0)
- Une dramaturgie de l’amour-propre : le théâtre de Racine (2004) (0)
- Constitutionnaliser un modèle donnant un sens aux finances publiques (2020) (0)
- Un petit bronze romain provenant de la Roque de Viou (commune de Saint-Dionizy, Gard). (2002) (0)
- Pour une nouvelle gouvernance financière : Repenser et reconstruire les finances publiques de demain (2004) (0)
- Desensibilisations specifiques aux venins d'hymenopteres : etude retrospective portant sur 806 cas : travail de l'unite de pneumologie et d'allergologie du centre hospitaliere saint-joseph-saint-luc (1994) (0)
- La conversation avec Dieu dans les Elévations Sur Les Mystères de Bossuet (1997) (0)
- Nouvelle gouvernance financière publique durable et conduite de la réforme budgétaire dans les pays en développement (2007) (0)
- L'hygiène urbaine à Lyon à l'époque gallo-romaine (1994) (0)
- Chaperons pharmacologiques pour le traitement de l'obésité (2006) (0)
- L'homme et les institutions sociales d'apres les "petits moralistes" francais, de 1659 a 1688 (1987) (0)
- Qui nous redira l'ardeur capiteuse, le bouquet enivrant du Falerne ? (2001) (0)
- Sortir du « quoi qu’il en coûte » : quelles réformes structurelles ? (2021) (0)
- Le Méthotrexate à faibles doses dans le traitement de la polyarthrite rhumatoïde (1989) (0)
- Les années 2000 (2015) (0)
- Depistage de composes grace a une fenetre d'activite independante du message chimique (1994) (0)
- La nouvelle gouvernance financière de l’Etat en France (2009) (0)
- RETROUVER LE GOUT DES VINS ANTIQUES (1998) (0)
- La feuille de cassis (2004) (0)
- Fiscalite L'imaginaire fiscal: des utopies fiscales a l'impot virtuel (2003) (0)
- Réformes : la culture de la performance n'est pas incompatible avec la diversité institutionnelle (2009) (0)
- Un système fiscal fronçais en mutation (2014) (0)
- Comment replacer le citoyen dans la gouvernance des finances publiques ? (2022) (0)
- Science des finances publiques : le quiproquo (2016) (0)
- Le Conseil constitutionnel et l'autonomie fiscale des collectivités territoriales : du quiproquo à la clarification (2011) (0)
- médecine/sciences 2011 (2011) (0)
- Maîtrise des finances locales : du pacte au contrat ? (2020) (0)
- Solidarités locales : les chartes intercommunales de développement et d'aménagement : actes du colloque (1986) (0)
- La réforme de la taxe professionnelle et les transformations de l'autonomie financière locale (2011) (0)
- Photophérèse extracorporelle : Quatre ans d'expérience à Genève (2000) (0)
- Functional effects oflong-term activation on human132-and f33-adrenoceptor signalling (1995) (0)
- Use of BRET‐based biosensors to characterize the adhesion GPCR ADGRE5/CD97 signalling profile (2018) (0)
- LB987 New insights into gpcr-transducer coupling (2017) (0)
- Chapter 3 Receptor regulation (1993) (0)
- Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real-time. (2021) (0)
- Measurement of Protein Synthesis and Glycosylation (2003) (0)
- Combining resonance energy transfer methods reveals a complex between the (cid:1) 2A -adrenergic receptor, G (cid:1) i1 (cid:2) 1 (cid:3) 2 , and GRK2 (2010) (0)
- Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion (2018) (0)
- Discovery of small organic compounds arresting arrestin functions (2011) (0)
- Phosphorylation oftherev GeneProduct ofHuman Immunodeficiency Virus Type1 (1988) (0)
- Editorial Board (2009) (0)
- [19] Crosstalk between tyrosine kinase and G-protein-linked signal transduction systems (1996) (0)
- Cardiomyocytes β-adrenergic receptors are resistants to short-term desensitization (2001) (0)
- Signaling profile of a new PAR2 inhibitor with anti‐inflammatory effects (2018) (0)
- Activation Receptor Endocytosis and ERK 1 / 2-Arrestin Recruitment Leading to Efficient β Receptor Carboxyl Tail Enhances Palmitoylation of the V 2 Vasopressin Mechanisms of Signal Transduction : (2003) (0)
- Running Title : Signalling and trafficking of NDI and NSIAD V 2 R mutations (2010) (0)
- Involvement of tyrosine residues located in the carboxyl tail of the human 82-adrenergic receptor in agonist-induced down-regulation of the receptor ( hormone signaling / internalization / adenylyl cyclase / mutagenesis / isoproterenol ) (0)
- Subtypes Optimizes -Adrenergic Modulation of Cardiac Contractility (2005) (0)
- COUPLING OF A G‐PROTEIN COUPLED RECEPTOR TO THE AGS3‐Galphai SIGNALING COMPLEX (2010) (0)
- Influence of receptor density on the patterns of beta2-adrenocepter desensitization. (1997) (0)
- Mapping G Protein‐coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: New Insights from Intact Cell Studies (2015) (0)
- Bioluminescence resonance energy transfer–based imaging of protein–protein interactions in living cells (2019) (0)
- TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40 (2013) (0)
- Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes (2019) (0)
- Identification and Characterization of UBE2O as a New β‐arrestin Interactor (2019) (0)
- Design, synthesis and study of conformationally constrained analogs of neuropeptide Y (1991) (0)
- cAMP stimulates transcription of the f 82-adrenergic receptor gene in response to short-term agonist exposure ( transcriptional activation / second messenger / epinephrine / transfection / down-regulation ) (0)
- Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy (2017) (0)
- Interaction of AGS4 and Gialpha1 in living cells (2009) (0)
- Oligomeric assembly of G protein-coupled receptors: Role in receptor trafficking and function (2002) (0)
- Identification of residues in human melatonin type 2 receptor involved in signaling selectivity or general signal transmission using natural variants (2017) (0)
- Probing the Functional Selectivity of β-adrenergic Receptors Reveals New Signaling Modes and Potential Therapeutic Applications (2013) (0)
- Peripheral actions of GPCRs in energy homeostasis: view from the Chair. (2014) (0)
- Identification of key regions mediating human melatonin type 1 receptor biased signaling revealed by natural variants (2018) (0)
- Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes (2018) (0)
- Detection, Validation, and Implications of GPCR Heterodimers (2011) (0)
- Probing G Protein-Coupled Receptor Signalling Complex Dynamics and Cellular Outcomes in Living Cells using Bioluminescence Resonance Energy Transfer (BRET) (2013) (0)
- Preparation of membrane receptors from extracellular baculoviruses (1997) (0)
- Differential Pharmacological Profiles of Different B-Blockers on Vascular Function in Atherosclerotic Mice (2013) (0)
- Antigen processing and presentation (PP-026) (2010) (0)
- Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs (2021) (0)
- Functional circadian and sleep phenotyping of type 2 diabetes patients with melatonin receptor 2 mutations and controls: a pilot study (2019) (0)
- Pyrazolopyridine et dérivés de pyrazolopyrimidine en tant que modulateurs du récepteur de la mélanocortine-4 (2012) (0)
- Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response (2020) (0)
- Monitoring Signalling and Trafficking of Neurotensin Type 1 Receptor in Animal Model using Fluorescent‐based Methods (2019) (0)
- The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens (2022) (0)
- Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing (2017) (0)
- Bioluminescence Resonance Energy Transfer (BRET)-based Imaging of G-Protein Coupled Receptor Signaling and Trafficking (2018) (0)
- G-protein coupling specificity of the human oxytocin receptor (2006) (0)
- Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 (2018) (0)
- Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs (2020) (0)
- Regulation of AGS3 and Gialpha1 interaction in living cells (2009) (0)
- f1-ADRENERGIC RECEPTORS (1988) (0)
- Usefulness of the Aldosterone-to-Renin Ratio for Screening Primary Aldosteronism Diastolic Dysfunction in Hypertensive Heart Disease (2003) (0)
- President ’ s Report 1999-2000 Buy-in from Patients , Health Care Community is Required for Future Progress Hypertension (2001) (0)
- Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response (2019) (0)
- [Metaphors, naming and new signaling paradigms by G-protein-coupled receptors]. (2012) (0)
- B-Raf Kinase in Complex with Birb796 (2013) (0)
- Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice (2022) (0)
- Abstract WP263: Mutagenesis Studies Revealed Minimal Impact of Human A120T Variant of Protease-activated Receptor 4 on Receptor function or Pharmacological Response to a Potent and Selective Antagonist (2016) (0)
- Faculty Opinions recommendation of Crystal Structure of an LSD-Bound Human Serotonin Receptor. (2017) (0)
- Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity (2017) (0)
- The AVPR2 mutation V88M is associated with both partial and complete nephrogenic diabetes insipidus (2009) (0)
- The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool. (2022) (0)
- Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction. (2022) (0)
- A Study of Intrachain and Interchain Reactions During Peptide Cyclization on the Kaiser Oxime Resin (1992) (0)
- Differential impact of three β‐adrenergic receptor antagonists on the vascular dysfunction of atherosclerotic mice (2012) (0)
- Microsoft Word-61775342-file00 (2009) (0)
- The Ubiquitination Status of the Glucagon Receptor determines Signal Bias. (2023) (0)
- Abstract LB187: EGFR signaling and pharmacology in oncology revealed with an innovative RTK biosensor technology (2021) (0)
- The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects (2020) (0)
- Development of small chemical tools modulating clathrin‐mediated GPCR endocytosis (2011) (0)
- Ackr3-Venus knock-in mouse lights up brain vasculature (2021) (0)
- Dysfunction ofthe/3-anda-Adrenergic Systems inaModelofCongestive HeartFailure (1991) (0)
- Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure. (2015) (0)
- Energy transfer–based approaches to study G protein–coupled receptor dimerization and activation (2005) (0)
- Effects of stimulation of vesical afferents on external anal sphincter motility in cats (1993) (0)
- Targeting the Internalization of the M3 Receptor: A Novel Way to Treat Asthma ? (2020) (0)
- Online‐Only Abstracts (2011) (0)
- [Role of the sympathetic nervous system in arterial hypertension]. (1985) (0)
- Prospective evaluation of the frequency of anal sphincter rupture in patients with constipation related to defecatory difficulty (1998) (0)
- forcetor density and enhances contractile β -blockade increases skeletal muscle β Chronic (2015) (0)
- 903 Impact of High-Level Sport Practice on the Prevalence of Anal Incontinence in a Young Healthy Female Population (2010) (0)
- [Role of enkephalins in the neural regulation of colonic motility ]. (1987) (0)
- Sa1360 Canal Anal Pressure Profile At Rest and During Squeezing in Controls and Patients With Fecal Incontinence: A Study Using 3D Ano-Rectal High Resolution Manometry (3D ARHRM) (2015) (0)
- Nervous Reflexes Involved in the Co-ordination of the Motility of internal Anal Sphincter and Urinary Bladder (1984) (0)
- La question de l'impôt idéal : L'impôt (2002) (0)
- 6. La vie religieuse (2000) (0)
- Les nouveaux traitements de fond de la polyarthrite rhumatoïde (1989) (0)
- Forme et contrainte de rupture de pastilles de detergent (1999) (0)
- Les années 2010 (2015) (0)
- du pacte de stabilité financière aux lois de finacement des collectivités territoriales (2016) (0)
- Dérivés d'imidazopyridine, d'imidazopyrimidine et d'imidazopyrazine en tant que modulateurs des récepteurs de mélanocortine-4 (2011) (0)
- L'épreuve de Dieu dans l'oeuvre de Bossuet (2008) (0)
- L'administration fiscale en France (1988) (0)
- Nouveau dialogue entre récepteurs et protéines G trimériques : « une danse à corps enlacés » (2007) (0)
- L'âge de la nouvelle gouvernance financière et de la responsabilisation généralisée des acteurs publics : un autre contrat social, un autreétat (2005) (0)
- Effects of trimebutine on the sphincter of Oddi motility in patients with post cholecystectimy pain (1998) (0)
- La corruption : une menace pour la démocratie, les finances publiques et le marché (2019) (0)
- Médecine/Sciences et les passerelles du temps Éditorial (2009) (0)
- Manométrie anorectale haute résolution : quelles avancées ?Manométrie anorectale haute résolution (2015) (0)
- Une nouvelle interprétation d'un tableau du calendrier agricole de Saint-Romain-en-Gal (2002) (0)
- Trois exemples de conservation des méthodes antiques de conduite de la vigne (2003) (0)
- Refonder un ordre juridique avec Georges Gurvitch (2015) (0)
- Une nouvelle interprétation des stèles de Grand (Vosges) (2012) (0)
- Pour une mobilisation générale contre le désarroi fiscal (2013) (0)
- Régions et métropoles : une impossible alliance ? (2018) (0)
- Finances publiques : manuel (1993) (0)
- Des chaperons pharmacologiques pour corriger le diabète insipide néphrogénique (2000) (0)
- Espoirs et défis en recherche biomédicale (2010) (0)
- L' autonomie financière locale en France : illusion ou refondation? (2016) (0)
- Données statistiques sur la répartition des allergies au venin d'hyménoptères dans le Rhône et les départements limitrophes À partir de l'expérience de l'Unité d'Allergologie du Centre Hospitalier Saint-Joseph et Saint-Luc (1996) (0)
- Etude des relations motrices entre la vessie et le côlon chez le Chat (1991) (0)
- L' impôt sur le revenu : entre échange et solidarité ? (2017) (0)
- Léon Bloy et La Salette (2000) (0)
- Le citoyen, la gouvernance financière publique et les mutations du politique (2016) (0)
- Quelle justice fiscale pour un monde en transition (2019) (0)
- La conversion de Julien Green (1999) (0)
- Les 3 chenes indigenes et leurs intermediaires (2012) (0)
- Le Tramway des Officiers ou du bon usage du coup de foudre (2004) (0)
- Sur L'Origine Des Plantes Alpines Et Sur La Question De L'Espèce (0)
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What Schools Are Affiliated With Michel Bouvier?
Michel Bouvier is affiliated with the following schools: