Michel C. Nussenzweig
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Brazilian immunologist
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Michel C. Nussenzweigbiology Degrees
Biology
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Immunology
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#70
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Biology
Michel C. Nussenzweig's Degrees
- Doctorate Medicine University of São Paulo
- PhD Immunology University of São Paulo
Why Is Michel C. Nussenzweig Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michel C. Nussenzweig is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.
Michel C. Nussenzweig's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo (2001) (1984)
- Tolerogenic dendritic cells. (2003) (1788)
- Autoantibodies against type I IFNs in patients with life-threatening COVID-19 (2020) (1744)
- Predominant Autoantibody Production by Early Human B Cell Precursors (2003) (1636)
- Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals (2020) (1577)
- Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020) (1524)
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks (2010) (1475)
- Genomic Instability in Mice Lacking Histone H2AX (2002) (1424)
- Differential Antigen Processing by Dendritic Cell Subsets in Vivo (2007) (1417)
- Inducing and expanding regulatory T cell populations by foreign antigen (2005) (1380)
- Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance (2002) (1359)
- Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance (2002) (1246)
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01 (2010) (1115)
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding (2011) (1073)
- H2AX: the histone guardian of the genome. (2004) (1034)
- Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter (2010) (1026)
- The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing (1995) (1020)
- SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies (2020) (1014)
- Blimp1 is a critical determinant of the germ cell lineage in mice (2005) (988)
- In Vivo Analysis of Dendritic Cell Development and Homeostasis (2009) (983)
- Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants (2020) (915)
- Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. (2008) (909)
- Origin of the lamina propria dendritic cell network. (2009) (887)
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals (2009) (869)
- mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) (831)
- Visualizing dendritic cell networks in vivo (2004) (817)
- Germinal centers. (2012) (800)
- The origin and development of nonlymphoid tissue CD103+ DCs (2009) (713)
- Defective B cell tolerance checkpoints in systemic lupus erythematosus (2005) (704)
- Evolution of antibody immunity to SARS-CoV-2 (2021) (703)
- Evolution of Antibody Immunity to SARS-CoV-2 (2020) (680)
- Requirement for Ku80 in growth and immunoglobulin V(D)J recombination (1996) (662)
- Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 (2015) (632)
- mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) (621)
- Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys (2013) (610)
- DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation (2000) (569)
- Dendritic Cells: Features and Functions (1980) (567)
- The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments (2000) (553)
- Origin and development of dendritic cells (2010) (552)
- A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling (1994) (550)
- AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching (2001) (528)
- Vaccine Breakthrough Infections with SARS-CoV-2 Variants (2021) (520)
- TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. (1997) (506)
- Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies (2012) (499)
- MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. (2008) (498)
- HIV therapy by a combination of broadly neutralizing antibodies in humanized mice (2012) (493)
- In vivo imaging of germinal centres reveals a dynamic open structure (2007) (483)
- AID Is Required for c-myc/IgH Chromosome Translocations In Vivo (2004) (482)
- Origin of dendritic cells in peripheral lymphoid organs of mice (2007) (479)
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization (2013) (474)
- Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. (1994) (474)
- Clonal selection in the germinal centre by regulated proliferation and hypermutation (2014) (473)
- Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection (2021) (471)
- Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance (2003) (471)
- Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage (2012) (468)
- Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis (2002) (461)
- Autoreactivity in human IgG+ memory B cells. (2007) (457)
- Antibodies in HIV-1 Vaccine Development and Therapy (2013) (456)
- Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia (2013) (449)
- AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations (2008) (447)
- Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand (2003) (445)
- CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells1 (2008) (432)
- Feedback control of regulatory T cell homeostasis by dendritic cells in vivo (2009) (428)
- Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies (2020) (418)
- Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants (2020) (417)
- Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity (2014) (412)
- Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland (2006) (411)
- Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion (1999) (409)
- Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching (2013) (400)
- Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies (2020) (394)
- Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation (2010) (392)
- AID is required for germinal center–derived lymphomagenesis (2008) (383)
- HIV-1 Integration Landscape during Latent and Active Infection (2015) (375)
- Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design (2011) (373)
- A Blueprint for HIV Vaccine Discovery. (2012) (372)
- Ku80 is required for immunoglobulin isotype switching (1998) (367)
- A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center (2011) (363)
- HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption (2016) (362)
- Role of genomic instability and p53 in AID-induced c-myc–Igh translocations (2006) (361)
- Notch2-dependent classical dendritic cells orchestrate intestinal immunity against attaching and effacing bacterial pathogens (2013) (358)
- Antibody 10-1074 suppresses viremia in HIV-1-infected individuals (2017) (354)
- Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5 (2010) (352)
- Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes (2011) (352)
- Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses (2020) (351)
- Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo (2005) (340)
- A robust pipeline for rapid production of versatile nanobody repertoires (2014) (335)
- A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12–independent but CD70-dependent mechanism in vivo (2007) (332)
- Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction (1980) (327)
- Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy (2014) (325)
- Combination therapy with anti-HIV-1 antibodies maintains viral suppression (2018) (324)
- The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry (2012) (322)
- Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice (2014) (321)
- 53BP1 is required for class switch recombination (2004) (319)
- 53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions (2013) (317)
- H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation (2003) (316)
- Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. (2012) (316)
- Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ (1996) (311)
- FMS-like tyrosine kinase 3 is required for dendritic cell development in peripheral lymphoid tissues (2008) (308)
- Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. (2013) (308)
- Chromatin dynamics and the preservation of genetic information (2007) (307)
- T-independent type II immune responses generate memory B cells (2006) (306)
- Enhanced SARS-CoV-2 neutralization by dimeric IgA (2020) (301)
- Role of BCR affinity in T cell–dependent antibody responses in vivo (2002) (299)
- 53BP1 facilitates long-range DNA end-joining during V(D)J recombination (2008) (299)
- Origin of Chromosomal Translocations in Lymphoid Cancer (2010) (298)
- Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques (2014) (297)
- Antibody regulation of B cell development (2000) (297)
- Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. (1987) (296)
- HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies (2016) (292)
- Plasma Neutralization of the SARS-CoV-2 Omicron Variant (2021) (292)
- Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo (2016) (287)
- Dynamic imaging of the immune system: progress, pitfalls and promise (2006) (287)
- 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination (2010) (285)
- T Follicular Helper Cell Dynamics in Germinal Centers (2013) (284)
- Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes (2001) (283)
- Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes (2011) (283)
- C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. (2003) (280)
- A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges (2016) (279)
- Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo (1997) (273)
- DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes (2007) (269)
- Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses (2006) (267)
- AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. (2009) (265)
- Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses (2020) (262)
- A monoclonal antibody specific for mouse dendritic cells. (1982) (261)
- Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors (2015) (260)
- The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites (2006) (258)
- Role of antigen receptor affinity in T cell–independent antibody responses in vivo (2002) (258)
- Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths (2021) (257)
- HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1 (2016) (257)
- HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice (2013) (255)
- Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico (2017) (255)
- AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges (2015) (254)
- Dendritic cells are accessory cells for the development of anti- trinitrophenyl cytotoxic T lymphocytes (1980) (254)
- V(D)J recombination in mature B cells: a mechanism for altering antibody responses. (1997) (253)
- The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes (1996) (252)
- Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice (2016) (249)
- A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling (1994) (248)
- Intensified and protective CD4+ T cell immunity in mice with anti–dendritic cell HIV gag fusion antibody vaccine (2006) (245)
- Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. (2011) (245)
- Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice (2015) (242)
- Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase (2004) (241)
- Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. (2004) (240)
- Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies (2021) (239)
- Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes. (1995) (239)
- Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo (2020) (236)
- Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models (2005) (235)
- Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow (2015) (234)
- Dynamic signaling by T follicular helper cells during germinal center B cell selection (2014) (233)
- Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice (2021) (233)
- B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity (2014) (227)
- ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions (2004) (225)
- Early antibody therapy can induce long-lasting immunity to SHIV (2017) (224)
- Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta (1993) (219)
- A checkpoint for autoreactivity in human IgM+ memory B cell development (2006) (217)
- Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike. (2014) (215)
- Route of Antigen Uptake Differentially Impacts Presentation by Dendritic Cells and Activated Monocytes (2010) (215)
- A method for identification of HIV gp140 binding memory B cells in human blood. (2009) (209)
- Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors (2008) (208)
- Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability (2014) (207)
- Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 (2012) (206)
- CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain (2008) (205)
- A Backup DNA Repair Pathway Moves to the Forefront (2007) (200)
- DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes (2012) (199)
- Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes (2007) (196)
- Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 (2010) (191)
- Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. (2009) (188)
- ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes (2007) (186)
- CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS (2007) (185)
- Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4 (2010) (183)
- Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination (2021) (183)
- The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. (2008) (182)
- Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site (2016) (182)
- Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain (2011) (182)
- Circulating precursors of human CD1c+ and CD141+ dendritic cells (2015) (181)
- Normal Host Defense during Systemic Candidiasis in Mannose Receptor-Deficient Mice (2003) (178)
- The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells (2016) (176)
- Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase. (2013) (175)
- Safety and anti-viral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals (2018) (174)
- Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein (2012) (172)
- Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations (2021) (170)
- B-cell self-tolerance in humans. (2007) (170)
- The Cysteine-Rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates a and B and Sulfated Oligosaccharides of Blood Group Lewisa and Lewisx Types in Addition to the Sulfated N-Glycans of Lutropin (2000) (170)
- Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium (2013) (167)
- Dynamic signaling by T follicular helper cells during germinal center B cell selection (2014) (162)
- T cell help controls the speed of the cell cycle in germinal center B cells (2015) (161)
- PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination (2010) (159)
- High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape (2021) (159)
- Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic (2019) (157)
- Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2. (1999) (156)
- Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA (2016) (154)
- Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. (2006) (153)
- Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice (2016) (152)
- The microanatomic segregation of selection by apoptosis in the germinal center (2017) (151)
- A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. (2009) (151)
- Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission (2013) (151)
- Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells (1998) (149)
- Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. (2005) (149)
- Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals (2020) (148)
- AID targeting in antibody diversity. (2011) (147)
- Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production (2000) (147)
- The role of Ig beta in precursor B cell transition and allelic exclusion. (1995) (146)
- Persistent expression of autoantibodies in SLE patients in remission (2006) (145)
- Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies (2004) (143)
- Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. (2001) (142)
- Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection (2013) (138)
- Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development. (2001) (138)
- A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. (2000) (137)
- Inflammasome activation in infected macrophages drives COVID-19 pathology (2022) (137)
- Contribution of Receptor Editing to the Antibody Repertoire (2001) (137)
- Hairpin coding end opening is mediated by RAG1 and RAG2 proteins. (1998) (137)
- Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection (2016) (136)
- Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates. (2010) (136)
- Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma (2015) (136)
- Regulation of class switch recombination and somatic mutation by AID phosphorylation (2008) (134)
- Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail (2001) (132)
- V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins (1997) (131)
- Enhanced intra‐switch region recombination during immunoglobulin class switch recombination in 53BP1–/– B cells (2007) (127)
- Extrathymic T Cell Lymphopoiesis: Ontogeny and Contribution to Gut Intraepithelial Lymphocytes in Athymic and Euthymic Mice (2003) (126)
- B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β (2001) (125)
- Immune Receptor Editing Revise and Select (1998) (125)
- Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller (2017) (125)
- Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1) (2012) (122)
- Sequencing and cloning of antigen-specific antibodies from mouse memory B cells (2016) (121)
- Development and migration of plasma cells in the mouse lymph node. (2010) (121)
- Crystal Structure of the Cysteine-Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand (2000) (121)
- Circulating human B cells that express surrogate light chains and edited receptors (2000) (120)
- Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo (2017) (120)
- Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency (2016) (119)
- Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes (2014) (117)
- Absence of the Macrophage Mannose Receptor in Mice Does Not Increase Susceptibility to Pneumocystis carinii Infection In Vivo (2003) (115)
- Progress toward active or passive HIV-1 vaccination (2017) (114)
- Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo (2017) (114)
- OCA‐B integrates B cell antigen receptor‐, CD40L‐ and IL 4‐mediated signals for the germinal center pathway of B cell development (1998) (113)
- Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates (2020) (112)
- Memory B Cell Antibodies to HIV-1 gp140 Cloned from Individuals Infected with Clade A and B Viruses (2011) (112)
- Polyreactive antibodies in adaptive immune responses to viruses (2012) (111)
- Computational analysis of anti–HIV-1 antibody neutralization panel data to identify potential functional epitope residues (2013) (111)
- Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost (2022) (110)
- Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants (2021) (109)
- DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. (1995) (109)
- Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory. (2016) (108)
- AID from bony fish catalyzes class switch recombination (2005) (107)
- Human Autoantibody Silencing by Immunoglobulin Light Chains (2004) (106)
- Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state (2012) (103)
- Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1 (2015) (103)
- Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 (2010) (102)
- B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-β1 (2002) (101)
- Germinal center reutilization by newly activated B cells (2009) (99)
- Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs (2016) (99)
- Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells (2015) (98)
- Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes (1995) (98)
- Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation (2016) (98)
- Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation (2018) (97)
- The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion (1995) (96)
- RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. (2013) (94)
- Classical Flt3L-dependent dendritic cells control immunity to protein vaccine (2014) (91)
- Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies (2013) (90)
- Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching (2015) (90)
- A role for AID in chromosome translocations between c-myc and the IgH variable region (2007) (90)
- RAGs and regulation of autoantibodies. (2004) (90)
- Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. (2003) (88)
- Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity. (2019) (86)
- Igβ tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization (2006) (84)
- Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike (2015) (84)
- Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity (2020) (84)
- A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection (2018) (83)
- OcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin κ Genes (2002) (83)
- Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants (2014) (82)
- Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells (2011) (81)
- A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer (2004) (79)
- The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. (1999) (79)
- Extrathymic T Cell Lymphopoiesis (2003) (78)
- The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo (2001) (76)
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- A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection (2018) (0)
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- Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape (2023) (0)
- Structure of a Natively-glycosylated HIV-1 Env Reveals a New Mode for VH1-2 Antibody Recognition of the CD4 Binding Site Relevant to Vaccine Design (2017) (0)
- A time of change (2017) (0)
- Plasma cell differentiation (WS-050) Chairpersons: Takeshi Tokuhisa, Stephen Nutt (2010) (0)
- Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain (2023) (0)
- Dendritic cells: function (PP-024) (2010) (0)
- Homing Adipose Tissue Dendritic Cells - Distribution of Antigen to Lymph Node Facilitates Adipose Tissue Inflammation and Collecting Lymphatic Vessel Permeability (2015) (0)
- G-108 Special lecture: HIV-1 prevention (2017) (0)
- Sequential Immunization Strategies to Elicit HIV-1 bNAbs in Animal Models With a Polyclonal B Cell Repertoire (2018) (0)
- Antigen-specific humoral immune responses by CRISPR/Cas9-edited B cells (2019) (0)
- Title: A naturally arising broad and potent CD4-binding site antibody with low somatic mutation 1 Short Title: An HIV-1 bNAb with low somatic mutation (2022) (0)
- Title Profiling risk and sustainability in coastal deltas of the world Permalink (0)
- Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity (2020) (0)
- Myeloid cells regulate plasma cell responses in the lymph node (P1066) (2013) (0)
- Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation (2018) (0)
- MonocytesCells and Activated (2010) (0)
- Initiating protective T cell immunity by targeting antigens directly to maturing dendritic cells in lymphoid tissues (2005) (0)
- Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer (2022) (0)
- Antibody Repertoire Surrogate Light Chains Display a Unique Circulating Human B Cells That Express (2001) (0)
- Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques (2019) (0)
- A Co-receptor-mimicking Antibody Stabilizes the Displaced V1V2 Loops in a Partially Open sCD4-bound HIV-1 Envelope Complex (2018) (0)
- Mu to Activate the Precursor B Cell Transit ion By Fotini Papavasiliou , Mila Jankovic (0)
- in the Lymph Node Antibody-Secreting Cells after Immunization Myeloid Cells Limit Production of (2013) (0)
- Author response: Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies (2017) (0)
- Erratum: Regulation of naive T cell function by the NF-κB pathway (Nature Immunology (2006) vol. 7 (763-772)) (2007) (0)
- Monoclonal Antibodies Protect Aged Rhesus Macaques From SARS-CoV2 Induced Immune Activation (2021) (0)
- Germinal center reaction (WS-031) Chairpersons: Nobuo Sakaguchi, Garnett Kelsoe (2010) (0)
- CD80+CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells (2020) (0)
- Co-crystals of broadly neutralizing antibody with the linear epitope from Hepatitis B surface antigen (2020) (0)
- Germinal Centers. (2022) (0)
- Targeting HIV using Structure-Based Rational Design of Antibodies (2014) (0)
- Antibody VRC 01 Structural Basis for Broad and Potent Neutralization of HIV-1 by (2014) (0)
- Genetic rearrangements (VDJ/CSR/SHM) (WS-080) Chairpersons: Ji-Yang Wang, Satoshi Takaki (2010) (0)
- MONDAY PUSHLIVE TEST L-Myc expression by dendritic cells is required for optimal T-cell priming (2014) (0)
- Lymphocyte activation and effector functions: Editorial overview (2000) (0)
- Molecular Mechanisms of B Cell Repertoire Diversification (2003) (0)
- Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice (2021) (0)
- Igao andlg,B AreFunctionally Homologous totheSignaling Proteins oftheT-Cell Receptor (1994) (0)
- JEM Editorial Board: Expanding on the basis of cancer (2019) (0)
- JEM Advisory Editorial Board: Increasing diversity. (2017) (0)
- Dendritic cells: function (PP-024) (2010) (0)
- Gene Editing of Primary Rhesus Macaque B Cells. (2023) (0)
- The new face of JEM (2017) (0)
- Abstract B144: Elucidating germinal center B cell metabolic states and their influence on selection (2016) (0)
- Crystal structure of the cysteine rich domain of mannose receptor complexed with Acetylgalactosamine-4-sulfate (2000) (0)
- Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope (2021) (0)
- Activation Induced Deaminase in Antibody Diversification and Chromosome Translocation (2015) (0)
- Regulatory T + Specialized to Induce Foxp3 Splenic Dendritic Cells Are + CD205+ CD8 (2008) (0)
- Dendritic cells: differentiation (WS-046) Chairpersons: Kayo Inaba, Laszlo Nagy (2010) (0)
- with Immunoglobulin (Ig) (cid:2) Immunoreceptor Tyrosine–based Activation Motif (ITAM) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig (cid:3) Cytoplasmic Tail (2001) (0)
- JEM goes viral (2020) (0)
- Igao and lg,B Are Functionally Homologous to the Signaling Proteins of the T-Cell Receptor (0)
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