Michele Pagano

Q: What Schools Are Affiliated With Michele Pagano

Michele Pagano is affiliated with the following schools: Florida State University, University of Verona, University of Virginia, University of Naples Federico II, New York University

Michele Pagano 's AcademicInfluence.com Rankings

Michele Pagano

Biology

#5587

World Rank

#8102

Historical Rank

Biochemistry

#707

World Rank

#807

Historical Rank

biology Degrees

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Biology

Michele Pagano 's Degrees

PhD Biochemistry University of Naples Federico II
Bachelors Chemistry University of Naples Federico II

Why Is Michele Pagano Influential?

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According to Wikipedia, Michele Pagano is an Italian-American biochemist and cancer biologist best known for his work on cell cycle control and the ubiquitin-proteasome system. He is currently the chairman of the Department of Biochemistry and Molecular Pharmacology, and the Ellen and Gerald Ritter Professor of Oncology at the New York University School of Medicine. He is also an Investigator of the Howard Hughes Medical Institute. His laboratory has played a central role in elucidating the role of a family of enzymes, the cullin-RING ubiquitin ligases , in mediating the proteolysis of key cellular regulators. In particular, his work has uncovered the molecular mechanisms by which CRLs control cell cycle progression, signal transduction pathways, and the DNA damage response. His work has also elucidated how the dysregulation of CRLs contributes to malignant transformation and metastasis, uncovering new therapeutic strategies.

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Michele Pagano 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. (1995) (1922)
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. (1993) (1613)
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 (1999) (1536)
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (2002) (1420)
Cyclin A is required at two points in the human cell cycle. (1992) (1410)
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition (1995) (1240)
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas (1997) (1122)
The SCF ubiquitin ligase: insights into a molecular machine (2004) (1074)
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008) (876)
Regulation of the Cdk inhibitor p27 and its deregulation in cancer (2000) (773)
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. (1999) (677)
The F-box protein family (2000) (659)
Systematic analysis and nomenclature of mammalian F-box proteins. (2004) (651)
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex (2000) (598)
S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth (2006) (592)
Mechanisms and function of substrate recruitment by F-box proteins (2013) (539)
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* (2003) (492)
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 (2001) (488)
SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins (2007) (481)
The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period (2007) (465)
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. (1997) (452)
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage (2003) (401)
The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin (1999) (398)
The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint (2008) (397)
Identification of a family of human F-box proteins (1999) (392)
Deregulated degradation of the cdk inhibitor p27 and malignant transformation. (2003) (392)
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. (1997) (373)
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (2008) (361)
Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation (2003) (355)
Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation (1998) (347)
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. (2006) (343)
Differential modulation of cyclin gene expression by MYC. (1993) (335)
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis (2001) (330)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts (1993) (319)
Role of the F-box protein Skp2 in lymphomagenesis (2001) (318)
Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo (2003) (315)
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. (1994) (314)
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. (2002) (312)
Skp2, the FoxO1 hunter. (2005) (311)
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1 (2019) (305)
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. (2004) (301)
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase (2004) (297)
Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair (2012) (293)
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. (1998) (290)
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. (2006) (288)
Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. (1994) (285)
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. (1994) (279)
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth (2006) (276)
Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes. (1995) (270)
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. (2005) (267)
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes (2007) (265)
SCF ubiquitin ligase-targeted therapies (2014) (254)
Novel p27kip1 C-Terminal Scatter Domain Mediates Rac-Dependent Cell Migration Independent of Cell Cycle Arrest Functions (2003) (249)
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas (2012) (244)
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein (2008) (242)
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. (2000) (240)
Cell cycle regulation by the ubiquitin pathway (1997) (236)
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. (1994) (233)
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. (2003) (230)
Association of cdk2 kinase with the transcription factor E2F during S phase. (1992) (230)
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer. (2014) (219)
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (2004) (219)
Dual mode of degradation of Cdc25 A phosphatase (2002) (217)
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. (2003) (217)
Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation during Growth Arrest* (1997) (214)
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. (1999) (211)
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. (2007) (211)
Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas (2001) (198)
Role of the Cdc25A phosphatase in human breast cancer. (2000) (197)
SCFFbxl3 Ubiquitin Ligase Targets Cryptochromes at Their Cofactor Pocket (2013) (190)
Control of chromosome stability by the β-TrCP–REST–Mad2 axis (2008) (185)
Specific small molecule inhibitors of Skp2-mediated p27 degradation. (2012) (184)
PTEN counteracts FBXL2 to promote IP3R3– and Ca2+–mediated apoptosis limiting tumour growth (2017) (177)
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. (2009) (176)
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. (2011) (174)
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. (1993) (174)
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division (2008) (173)
SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation (2010) (172)
Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation (1997) (169)
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. (2004) (166)
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. (1998) (165)
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma (2012) (164)
SKP 2 is required for ubiquitin-mediated degradation of the CDK inhibitor p 27 (1999) (162)
Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor (2000) (154)
Control of cell growth by the SCF and APC/C ubiquitin ligases. (2009) (152)
SnapShot: F Box Proteins II (2009) (150)
Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle Progression (2001) (147)
PHOTACs enable optical control of protein degradation (2020) (134)
Regulation of the G1 to S transition by the ubiquitin pathway (2001) (133)
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state (2008) (131)
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα* (1999) (130)
The ubiquitin-mediated proteolytic pathway as a therapeutic area (1997) (129)
Ubiquitin-dependent Degradation of p73 Is Inhibited by PML (2004) (128)
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. (1993) (128)
Rescue of defective mitogenic signaling by D-type cyclins. (1995) (127)
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110 (2013) (126)
S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase. (2002) (121)
Role of the Ubiquitin Proteasome System in the Heart (2013) (121)
Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). (1995) (113)
Stabilizers and destabilizers controlling cell cycle oscillators. (2006) (113)
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade (2013) (112)
SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP 110 degradation (2010) (110)
The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer (2000) (109)
"In vitro" study of basement membrane degradation by the cysteine proteinases, cathepsins B, B-like and L. Digestion of collagen IV, laminin, fibronectin, and release of gelatinase activities from basement membrane fibronectin. (1993) (109)
The Integrator complex controls the termination of transcription at diverse classes of gene targets (2015) (101)
Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. (1992) (100)
When protein destruction runs amok, malignancy is on the loose. (2003) (99)
SnapShot: F Box Proteins I (2009) (99)
Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis. (2004) (99)
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 (2009) (97)
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. (2000) (97)
Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation* (2002) (91)
Role of F-Box Protein βTrcp1 in Mammary Gland Development and Tumorigenesis (2004) (91)
Ubiquitin-dependent Degradation of Cyclin B Is Accelerated in Polyploid Megakaryocytes* (1998) (91)
Oncogenic aberrations of cullin-dependent ubiquitin ligases (2004) (90)
Cell cycle and cancer: critical events at the G1 restriction point. (1996) (90)
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation (2009) (85)
Wagging the Dogma Tissue-Specific Cell Cycle Control in the Mouse Embryo (2004) (85)
SCF ubiquitin ligases in the maintenance of genome stability. (2012) (83)
INTS3 controls the hSSB1-mediated DNA damage response (2009) (83)
Coupled Activation and Degradation of eEF2K Regulates Protein Synthesis in Response to Genotoxic Stress (2012) (83)
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma (2012) (80)
Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. (2004) (80)
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70 (2001) (77)
Cyclin A‐ and cyclin B‐dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. (1992) (76)
A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. (2013) (75)
Cell cycle, proteolysis and cancer. (2004) (75)
DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. (2007) (75)
Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase (2005) (74)
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing (2014) (73)
Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients. (2003) (73)
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage (2011) (72)
Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis. (2003) (70)
Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. (2013) (69)
The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival (2010) (68)
Cdk1: the dominant sibling of Cdk2 (2005) (68)
Induction of β-Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-κB* (2001) (67)
DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. (2014) (66)
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma (2004) (63)
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation (1994) (62)
TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response (2015) (61)
Structural Basis of the Cks 1-Dependent Recognition of p 27 Kip 1 by the SCFSkp 2 Ubiquitin Ligase (2005) (61)
Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. (2019) (60)
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity (2021) (60)
Degradation of cyclin A is regulated by acetylation (2009) (58)
Cdh1: a master G0/G1 regulator (2008) (57)
In Vivo Interference with Skp1 Function Leads to Genetic Instability and Neoplastic Transformation (2002) (56)
The ULK1-FBXW5-SEC23B nexus controls autophagy (2018) (56)
Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. (2016) (56)
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. (2020) (55)
Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. (2009) (55)
A peptidomimetic siRNA transfection reagent for highly effective gene silencing. (2006) (54)
CRL4AMBRA1 is a master regulator of D-type cyclins (2021) (51)
Immunohistochemical and biochemical study of a cathepsin B-like proteinase in human colonic cancers. (1988) (50)
Wnt signaling in mitosis. (2009) (49)
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival (2014) (48)
Clinical relevance of SKP2 alterations in metastatic melanoma (2011) (47)
Constitutive Phosphorylation of Aurora-A on Ser51 Induces Its Stabilization and Consequent Overexpression in Cancer (2007) (47)
Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog (PTEN) and Regulates Its Mitotic Activity during the Cell Cycle* (2014) (47)
Experimental tests to definitively determine ubiquitylation of a substrate. (2005) (46)
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer (2021) (45)
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. (2019) (45)
Don't Skip the G1 Phase: How APC/CCdh1 Keeps SCFSKP2 in Check (2004) (45)
Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. (2008) (44)
Critical role for IL-1β in DNA damage-induced mucositis (2014) (43)
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress (2013) (42)
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. (2010) (41)
Mechanism of p53 degradation. (1997) (41)
GGTase3 is a Newly Identified Geranylgeranyltransferase Targeting a Ubiquitin Ligase (2019) (40)
Cell Cycle — Materials and Methods (1996) (40)
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. (2019) (39)
Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2 (2010) (37)
Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes (2007) (36)
To Be or Not to Be...Ubiquitinated? (2004) (36)
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells (2017) (36)
Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27Kip1* (2006) (35)
Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis (2013) (35)
Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer. (2010) (34)
The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein (2001) (33)
Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB. (2001) (33)
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization (2010) (33)
Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein (2017) (32)
Inhibition of membrane fusion in vitro via cyclin B but not cyclin A. (1992) (31)
APC/CCdh1 controls the proteasome-mediated degradation of E2F3 during cell cycle exit (2012) (31)
Role of the SCF Skp2 Ubiquitin Ligase in the Degradation of p21 Cip1 in S Phase* (2003) (31)
Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors (2000) (31)
FBXO 11 targets BCL 6 for degradation and is inactivated in diffuse large B-cell lymphomas (2011) (31)
Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line. (1992) (31)
Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia (2000) (31)
BubR1 Is Modified by Sumoylation during Mitotic Progression* (2011) (29)
PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading (2018) (29)
β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression (2018) (29)
Multisite Phosphorylation of Nuclear Interaction Partner of ALK (NIPA) at G2/M Involves Cyclin B1/Cdk1*♦ (2007) (28)
Cyclin A, cell cycle control and oncogenesis. (1991) (27)
TrCP-and Rsk 1 / 2-Mediated Degradation of BimEL Inhibits Apoptosis (2009) (27)
The glycosylation state of the precursors of the cathepsin B-like proteinase from human malignant ascitic fluid: possible implication in the secretory pathway of these proenzymes. (1989) (27)
FEM1 proteins are ancient regulators of SLBP degradation (2017) (25)
A heat stable low molecular weight inhibitor of lysosomal cysteine proteinases in human serum. (1983) (24)
GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. (2017) (24)
SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer. (2015) (23)
Cell Division, a new open access online forum for and from the cell cycle community (2006) (23)
Competition between plasminogen and procathepsin B as a probe to demonstrate the in vitro activation of procathepsin B by the tissue plasminogen activator. (1996) (22)
The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. (2011) (22)
Purification and characterization of the activated mineralocorticoid receptor from rat myocardium. (1990) (22)
Butyrolactone: More than a Kinase Inhibitor? (2002) (22)
Activation-inactivation of hormone binding sites of the oestradiol-17 beta receptor is a multiregulated process. (1986) (21)
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion (2021) (20)
MCL1 meets its end during mitotic arrest (2011) (20)
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes. (2012) (20)
Cdh1, a Substrate-recruiting Component of Anaphase-promoting Complex/Cyclosome (APC/C) Ubiquitin E3 Ligase, Specifically Interacts with Phosphatase and Tensin Homolog (PTEN) and Promotes Its Removal from Chromatin* (2014) (20)
Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase* (2007) (20)
Generation of polyclonal antibodies against the mineralocorticoid receptor and analysis of mineralocortin in rat myocardium by immunophotochemistry. (1992) (20)
Kip1 degradation via the ubiquitin-proteasome pathway. (1997) (20)
Inhibition of chondrocyte cathepsin B and L activities by insulin-like growth factor-II (IGF-II) and its Ser29 variant in vitro: possible role of the mannose 6-phosphate/IGF-II receptor (1995) (20)
The G protein–coupled receptor GPR31 promotes membrane association of KRAS (2017) (20)
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target (2021) (20)
Ubiquitin ligases in cancer: functions and clinical potentials. (2021) (19)
FBH1 protects melanocytes from transformation and is deregulated in melanomas (2013) (18)
The Acidic Tail domain of Human Cdc34 is Required for p27Kip1 Ubiquitination and Complementation of a cdc34 Temperature Sensitive Yeast Strain (2005) (18)
Phosphorylation and estradiol binding of estrogen receptor in hormone‐dependent and hormone‐independent GR mouse mammary tumors (1992) (18)
Phosphorylation on tyrosine of oestradiol-17 beta receptor in uterus and interaction of oestradiol-17 beta and glucocorticoid receptors with antiphosphotyrosine antibodies. (1987) (17)
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis (2020) (17)
Role of the Cdc 25 A phosphatase in human breast cancer (2000) (17)
American Idol and NIH Grant Review (2006) (17)
NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. (2018) (16)
SCF-Mediated Degradation of p100 (NF-κB2): Mechanisms and Relevance in Multiple Myeloma (2012) (16)
Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism (2019) (16)
Inhibition of human liver cathepsin L by α‐thiol proteinase inhibitor (1982) (16)
ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection (2021) (16)
Cyclin A isrequired attwopoints inthehumancell cycle (1992) (15)
Inhibition of cathepsin L and B by haptoglobin, the haptoglobin-hemoglobin complex, and asialohaptoglobin. "In vitro" studies in the rat. (1982) (15)
Inhibition of the cathepsin B like proteinase by a low molecular weight cysteine-proteinase inhibitor from ascitic fluid and plasma alpha 2 macroglobulin. (1986) (15)
High-performance liquid chromatographic method for the simultaneous purification of cathepsins B, H and L from human liver. (1991) (15)
Kinetic study of the interaction between rat haptoglobin and rat liver cathepsin B. (1980) (14)
Quantitative study of the binding of cysteine proteinases to basement membranes (1992) (13)
FBXW5 controls centrosome number (2011) (13)
Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFβTrCP ubiquitin ligases (2011) (13)
Inhibition of human liver cathepsin L by alpha 2 cysteine-proteinase inhibitor and the low-Mr cysteine proteinase inhibitor from human serum. (1984) (11)
APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation. (2008) (11)
Targeting Ubiquitin-Mediated Degradation for Proliferation Inhibitors (1996) (11)
"In vitro" digestion of intact bovine lens capsules by four human lysosomal cysteine-proteinases. (1990) (11)
Regulation of the Cell Cycle by the cdk 2 Protein Kinase in Cultured Human Fibroblasts (2002) (10)
Phosphorylation of uterus estradiol receptor on tyrosine. (1990) (10)
Cdc25 phosphatases (2010) (10)
Binding of the cysteine proteinases papain and cathepsin B-like to coated laminin: use of synthetic peptides from laminin and from the laminin binding region of the beta 1 integrin subunit to characterize the binding site. (1998) (10)
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]. (1989) (10)
Immunophotochemical analysis of mineralocortin by polyclonal antibodies against the native receptor from rat kidney. (1992) (10)
Expression of collagenase/gelatinase activity from basement-membrane fibronectin--isolation after limited proteolysis of a bovine lens capsule and molecular definition of this thiol-dependent zinc metalloproteinase. (1998) (9)
Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis (2021) (9)
Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments (2020) (9)
Chapter 25. Cell Cycle Control and Cancer (1996) (9)
Don't run biomedical science as a business (2017) (9)
Purification and characterization of the activated mineralocorticoid receptor from rat kidney. (1990) (9)
Altered Expression of p 27 and Skp 2 Proteins in Prostate Cancer of African-American Patients 1 (2003) (8)
Cell Cycle Regulation of Nuclear Factor p92 DNA-binding Activity by Novel Phase-specific Inhibitors (*) (1996) (8)
Cell Cycle Control (2013) (8)
Regulation of the cell cycle by the ubiquitin pathway. (1998) (7)
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation (2020) (6)
Loss of p27KIP1 expression in fully-staged node-negative breast cancer: association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinoma. (2011) (6)
A 67 kDa non‐hormone binding estradiol receptor is present in human mammary cancers (1996) (6)
proteins Systematic analysis and nomenclature of mammalian F-box data (2004) (6)
α2 High molecular mass cysteine proteinase inhibitor: HMrα2‐CPI (1984) (6)
cdc2 protein kinase: structure-function relationships. (1992) (6)
Mixed ubiquitin chains regulate DNA repair (2019) (6)
Phosphorylation of estradiol receptor on tyrosine and interaction of estradiol and glucocorticoid receptors with antiphosphotyrosine antibodies. (1988) (5)
[Regulation of neoplasm-specific cathepsin B by cysteine-protease inhibitors present in cancerous exudates]. (1985) (5)
Modification of Cul1 regulates its association with proteasomal subunits (2006) (5)
Cryptochromes-mediated Inhibition of the CRL4Cop1- Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism (2019) (5)
Purification and characterization of two different precursor forms of the cathepsin B-like proteinase from human malignant ascitic fluid. (1988) (5)
INTS 3 controls the hSSB 1-mediated DNA damage response (2009) (5)
Cryptochromes-Mediated Inhibition of the CRL4 Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism (2019) (4)
Control of the Cell Cycle by the Ubiquitin System (2006) (4)
Epigenetic suppression of FBXL7 promotes metastasis (2020) (4)
Varshavsky's Contributions (2004) (4)
APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit (2020) (3)
A 67 kDa non-hormone binding estradiol receptor is present in human mammary cancers. (1996) (3)
[Digestion in vitro of basal membrane, bovine lens capsule, by human liver lysosome cathepsins B, H and L and ascitic fluid tumor cathepsin B from ovarian adenocarcinoma]. (1990) (3)
SCF Cyclin F controls centrosome homeostasis and mitotic fidelity via CP 110 degradation (2016) (3)
Properties of the mineralocorticoid receptor immunopurified from bovine kidney. (1994) (3)
On board. (2003) (3)
Reconstitution of p 53-ubiquitinylation reactions from purified components : The role of human ubiquitin-conjugating enzyme UBC 4 and E 6-associated protein ( E 6 AP ) ( human papilloma virus / cervical cancer / degradation ) (2005) (3)
The Long-Lost Ligase: CRL4AMBRA1 Regulates the Stability of D-Type Cyclins (2021) (3)
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress (2013) (2)
From Peptide to Purified-Antibody (1996) (2)
Faculty Opinions recommendation of Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. (2010) (2)
The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention (2000) (2)
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors (2022) (2)
Induction of b-Transducin Repeat-containing Protein by JNK Signaling and Its Role in the Activation of NF-kB* (2001) (2)
Plk 1 Protein Phosphorylates Phosphatase and Tensin Homolog ( PTEN ) and Regulates Its Mitotic Activity during the Cell Cycle * (2014) (2)
A cyclin without CDKs: Cyclin F controls genome stability through ubiquitin-mediated proteolysis (2013) (1)
BubR1 is modified by sumoylation during mitotic progression. (2016) (1)
Alpha 2 high molecular mass cysteine proteinase inhibitor: HMr alpha 2-CPI. An inhibitor of human liver cathepsin H as probed by kinetic study. (1984) (1)
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. (2016) (1)
PHOTACs Enable Optical Control of Protein Degradation. (2019) (1)
Ritonavir Sensitizes Multiple Myeloma Cells to Bortezomib-Induced Apoptosis (2008) (1)
The association between overexpression of skp2 and the risk of recurrence following prostatectomy (2008) (1)
The p27 ubiquitin ligase skp2 is overexpressed in breast cancer (2001) (1)
Erratum: Inhibition of membrane fusion in vitro via cyclin B but not cyclin A (Journal of Biological Chemistry (1992) 267 (6183-6187)) (1992) (1)
Inhibition of human liver cathepsin L by alpha-thiol proteinase inhibitor. (1982) (1)
Inhibition of human liver cathepsins B, H and L by the human α2 cysteine proteinase inhibitor (1986) (1)
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis (2020) (1)
Comparison of cysteine-proteinases inhibitory properties of human high-molecular-weight-kininogen (HMrK) purified from plasma and serum. (1992) (1)
The pRb–Cdh1–p27 autoamplifying network (2007) (1)
PHOTACs enable optical control of targeted protein degradation (2020) (1)
Designing a New Frontiers-class Trojan/Centaur Reconnaissance Mission: A JPL Planetary Science Summer School Study (2008) (1)
Faculty Opinions recommendation of Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. (2005) (0)
Beware the baited hook of publicity (2001) (0)
proteinsanalysis and nomenclature of mammalian F-box (2006) (0)
Raw, not cropped supporting Western blot files for: Rona, G., ... Pagano, M.: PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. Elife 7 (2018). (2018) (0)
Crystal structure of the Skp1-Skp2-Cks1 complex (2005) (0)
Mechanism of Action of Estrogens: Phosphorylation of Estradiol Receptor on Tyrosine (1990) (0)
Faculty Opinions recommendation of Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet). (2015) (0)
Author response: PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading (2018) (0)
Faculty Opinions recommendation of Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. (2021) (0)
Faculty Opinions recommendation of Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. (2007) (0)
Luca Busino , Cryptochrome Proteins Clock by Directing the Degradation of Controls the Oscillation of the CircadianFbxl 3 SCF (2007) (0)
Ink 4 Cyclin-dependent Kinase 4 Inhibitor p 16 Differential Expression and Cell Cycle Regulation of the Updated Version (2006) (0)
Centrosome homeostasis is controlled by ubiquitylation and deubiquitylation cycles (2012) (0)
Effect of the ribosome-inactivating protein saporin 6 on gene expression and kinase activity in leukemic cells (1991) (0)
Faculty Opinions recommendation of Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. (2002) (0)
p27/Kip.1 ubiquitin ligase subunit skp2 relationships with cell proliferation and p27/Kip.1 expression in gliomas (2001) (0)
Raw, not cropped supporting Western blot files for: Marzio A. ... Pagano M. The F-box domain-dependent activity of EMI1 regulates PARPi sensitivity in triple negative breast cancers. Mol Cell (2019) (2019) (0)
Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation (2023) (0)
Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCF βTrCP (2021) (0)
Loss of the deubiquitinase OTULIN promotes hepatocellular carcinoma (HCC) in an mTOR-dependent manner (2020) (0)
Faculty Opinions recommendation of Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. (2003) (0)
Faculty Opinions recommendation of The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. (2006) (0)
Non-Small Cell Lung Cancer Prognostic Role of the Cyclin-dependent Kinase Inhibitor p 27 in Updated (2006) (0)
Protein degradation is not chaos: Ubiquitin and the Biology of the Cell, edited by Jan-Michael Peters, J. Robins Harris and Daniel Finley (1999) (0)
A ubiquitin ligase-substrate complex (2013) (0)
Faculty Opinions recommendation of An Autophagic Flux Probe that Releases an Internal Control. (2018) (0)
Advances in Uterus Estradiol Receptor Phosphorylation on Tyrosine and Preliminary Evidences That Liver Glucocorticoid Receptor Might Be Phosphorylated on Tyrosine (1988) (0)
Faculty Opinions recommendation of Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. (2007) (0)
Faculty of 1000 evaluation for The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. (2018) (0)
The TDH–GCN5L1–Fbxo15–KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells (2017) (0)
Faculty Opinions recommendation of The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery. (2017) (0)
FBXO11 (F-box protein 11) (2017) (0)
Faculty Opinions recommendation of Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein. (2001) (0)
FBXO38 does not control PD-1 stability (2023) (0)
Faculty Opinions recommendation of Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. (2008) (0)
Raw, not cropped supporting Western blot files for: Clijsters, L. ... Pagano, M. Cyclin F controls cell cycle transcriptional outputs by directing the degradation of the three activator E2Fs. Mol. Cell (2019) (2019) (0)
Regulation of p27 Degradation (2002) (0)
Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome (2020) (0)
EVIENCE THAT IGF 2 INTERFERES WITH THE LYSOSOMAL ENZYME ACTIVITIES OF CARTILAGE CELLS IN VITRO (1993) (0)
Modulation ofCyclin GeneExpression byAdenovirus ElAina Cell LinewithElA-Dependent Conditional Proliferation (1994) (0)
MinireviewStabilizers and Destabilizers Controlling Cell Cycle Oscillators (0)
A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma (2021) (0)
Two different ubiquitin ligases control the abundance of Claspin at different phases of the cell cycle (2007) (0)
Faculty Opinions recommendation of Retromer has a selective function in cargo sorting via endosome transport carriers. (2019) (0)
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. (2017) (0)
Faculty Opinions recommendation of The kinetochore receptor for the cohesin loading complex. (2017) (0)
Decision letter: Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2 (2021) (0)
Cell Division (1999) (0)
a vertebrate cryptochrome with FAD (2013) (0)
Raw, uncropped supporting Western blot files for: Reynders M. et al. ... Pagano M. and Trauner D., PHOTACs enable optical control of protein degradation. Science Advances 2020 (2020) (0)
Faculty Opinions recommendation of A proximity-tagging system to identify membrane protein-protein interactions. (2018) (0)
SCFFbxo45 controls cytokinesis through ubiquitin‐mediated proteolysis of GEF‐H1 (2012) (0)
Methods Preparation of Proteins and Antibodies Puri®cation of Pid from Nuclear Extracts P53 Deacetylation Assay (0)
Book Review:Proteinase Inhibitors: Medical and Biological Aspects. Nobuhiko Katunuma, Hamao Umezawa, Helmut Holzer (1984) (0)
β-TrCP and Casein Kinase IIα Mediated Degradation of Cyclin F Controls Timely Mitotic Entry (2018) (0)
Targeting SCF Ub Ligase and APC/C (2007) (0)
Identification of GGTase3: an Ubiquitin Ligase-Targeting Geranylgeranyltransferase (2019) (0)
238 Oncogenic aberrations of SCF ubiquitin ligases (2004) (0)
Skp2, a prognostic marker and potential therapeutic target in metastatic melanoma. (2009) (0)
Cell cycle control by the ubiquitin system in mammals (2009) (0)
b-TrCP-and Casein Kinas e II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression Graphical (2018) (0)
[Physiopathological significance of inflammatory reaction proteins]. (1980) (0)
A vertebrate cryptochrome (2013) (0)
Extracellular matrix stiffness regulates degradation of MST2 via SCF βTrCP. (2022) (0)
Faculty Opinions recommendation of The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. (2018) (0)
Author response: The ULK1-FBXW5-SEC23B nexus controls autophagy (2018) (0)
Faculty Opinions recommendation of Mitochondrial ubiquinol oxidation is necessary for tumour growth. (2020) (0)
Faculty Opinions recommendation of KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. (2013) (0)
Faculty Opinions recommendation of Widespread mitotic bookmarking by histone marks and transcription factors in pluripotent stem cells. (2017) (0)
REGULATION OF HORMONE BINDING OF 17β-ESTRADIOL RECEPTOR BY TYROSINE PHOSPHORYLATION AND PHOSPHOTYROSINE DEPHOSPHORYLATION OF THE RECEPTOR (1987) (0)
Response: More Money and Less Time! (2006) (0)
Spindle assembly checkpoint inactivation: A new role for phosphatases (2010) (0)
A research on modification of bituminous binders' rheological characteristics through RTFOT (1993) (0)
upfront hot of f the press MCL 1 meets its end during mitotic arrest (2011) (0)
Theoretical investigations on the instability of steel frames in the elasto-plastic range (1967) (0)
Tumorigenesis and Neoplastic Progression Tumor Suppressor Function of Androgen Receptor Coactivator ARA 70 in Prostate Cancer (2010) (0)
Cyclin-dependent Kinase 4 Inhibitor p16Ink4 Differential Expression and Cell Cycle Regulation of the (2013) (0)
Raw, not cropped supporting Western blot files for: Mavrommati, I., ... Pagano, M., D'Angiolella, V.: β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep. (2018) (2018) (0)
GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase (2019) (0)
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide (2005) (0)
CDT1, a licensing factor that limits rereplication. (2023) (0)
Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
Deregulation of the Ubiquitin Ligase Subunit Skp2 in Breast Cancer (2002) (0)
Raw, not cropped supporting Western blot files for: Rizzini L. ... Pagano M. Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Current Biol. 2019 (2019) (0)
Linking ubiquitin to actin dynamics during cell fusion. (2021) (0)
Faculty Opinions recommendation of Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. (2002) (0)
[Quantitative binding of cysteine-proteinases to a basement membrane: role in their digestion during tumor invasion]. (1993) (0)
Faculty Opinions recommendation of The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. (2004) (0)
Cell Line with ElA-Dependent Conditional Proliferation (0)
Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome (2020) (0)
Faculty Opinions recommendation of CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. (2015) (0)

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