Miguel C. Seabra

Q: What Schools Are Affiliated With Miguel C. Seabra

Miguel C. Seabra is affiliated with the following schools: University of Texas Southwestern Medical Center, University of Coimbra, University of Lisbon, University of Porto, Imperial College London, University College London, NOVA University Lisbon, University of Washington

Miguel C. Seabra's AcademicInfluence.com Rankings

Miguel C. Seabra

Physics

#6671

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#8647

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Physics

Miguel C. Seabra's Degrees

PhD Physics University of Lisbon
Masters Physics University of Lisbon
Bachelors Physics University of Lisbon

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Miguel C. Seabra's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Rab27a and Rab27b control different steps of the exosome secretion pathway (2010) (1917)
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells (2006) (834)
Evolution of the Rab family of small GTP-binding proteins. (2001) (784)
Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides (1990) (701)
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial (2014) (697)
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin (2015) (566)
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. (2000) (479)
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. (2012) (477)
Rab GTPases, intracellular traffic and disease. (2002) (475)
The melanosome: membrane dynamics in black and white (2001) (441)
Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria1 (2006) (414)
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes (2001) (412)
1 Rab 27 a and Rab 27 b control different steps of the exosome secretion pathway (2009) (391)
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells (2014) (351)
Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes (2001) (328)
GTPase activity of Rab5 acts as a timer for endocytic membrane fusion (1996) (326)
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein (1993) (314)
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. (1993) (313)
Controlling the location and activation of Rab GTPases. (2004) (309)
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit (1991) (301)
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. (1992) (289)
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product (1992) (284)
Membrane association and targeting of prenylated Ras-like GTPases. (1998) (276)
Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases Published, JLR Papers in Press, January 9, 2006. (2006) (270)
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes (2006) (265)
A Family of Rab27-binding Proteins (2002) (254)
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes (2007) (234)
Rab escort protein‐1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. (1994) (234)
Rab GTPases and Myosin Motors in Organelle Motility (2004) (222)
Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia (*) (1995) (214)
Melanosomes at a glance (2008) (208)
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. (2010) (189)
Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease (2001) (185)
Rab27b regulates number and secretion of platelet dense granules (2007) (177)
Thousands of Rab GTPases for the Cell Biologist (2011) (176)
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells (2014) (165)
REP-2, a Rab escort protein encoded by the choroideremia-like gene. (1994) (165)
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. (2002) (164)
Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice* (2001) (162)
A general role for Rab27a in secretory cells. (2003) (161)
Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages* (2001) (159)
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. (2000) (157)
The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes (2002) (155)
Protein Prenyltransferases (*) (1996) (153)
Membrane targeting of Rab GTPases is influenced by the prenylation motif. (2003) (146)
Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (1994) (138)
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. (1991) (137)
The melanosome as a model to study organelle motility in mammals. (2004) (136)
Expression of the VLDL receptor in endothelial cells. (1996) (127)
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (120)
Multiple regions contribute to membrane targeting of Rab GTPases (2004) (120)
Fatty acylation and prenylation of proteins: what's hot in fat. (2005) (119)
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. (2006) (116)
Rab27b Regulates Mast Cell Granule Dynamics and Secretion (2007) (112)
Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience. (2018) (110)
Visual Acuity after Retinal Gene Therapy for Choroideremia. (2016) (105)
Mechanism of Digeranylgeranylation of Rab Proteins (1996) (104)
Rab GTPases Containing a CAAX Motif Are Processed Post-geranylgeranylation by Proteolysis and Methylation* (2007) (102)
Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis. (2014) (102)
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells (2009) (101)
Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. (2000) (101)
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. (2004) (99)
Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation (2010) (99)
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type (2003) (98)
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo. (2005) (97)
A role for Rab27b in NF-E2-dependent pathways of platelet formation. (2003) (97)
Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. (2001) (96)
Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex. (1998) (94)
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. (2007) (93)
Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms (2010) (92)
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes (2007) (91)
The Ternary Rab27a–Myrip–Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium (2007) (91)
Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). (1996) (85)
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. (2010) (84)
Targeting of Rab GTPases to cellular membranes. (2005) (83)
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. (2006) (82)
Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. (1991) (80)
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (79)
Melanosomes on the move: a model to understand organelle dynamics. (2011) (76)
A Family of Rab27-binding Proteins MELANOPHILIN LINKS Rab27a AND MYOSIN Va FUNCTION IN MELANOSOME TRANSPORT* (2002) (76)
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. (1993) (76)
Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment (2015) (76)
Novel functions for Rab GTPases in multiple aspects of tumour progression (2012) (75)
Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von‐Willebrand Factor Release from Endothelial Cells (2011) (73)
Multiple Factors Contribute to Inefficient Prenylation of Rab27a in Rab Prenylation Diseases* (2003) (73)
A practical diagnostic test for choroideremia. (1998) (71)
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro. (1994) (70)
Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13‐4 in mast cell secretion (2012) (67)
Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli (2017) (66)
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. (2010) (65)
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. (2008) (64)
Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics (2019) (63)
New insights into the pathogenesis of choroideremia: a tale of two REPs. (1996) (61)
Geranylgeranylation of Rab proteins. (1996) (61)
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. (2005) (60)
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. (2010) (57)
Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes* (2008) (56)
Rab and Arf Proteins in Genetic Diseases (2013) (54)
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus (2003) (53)
Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase* (2009) (53)
Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium (2013) (53)
Host cell autophagy contributes to Plasmodium liver development (2016) (53)
The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver Stage Development (2012) (50)
Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry (2010) (50)
Nucleotide Dependence of Rab Geranylgeranylation (1996) (48)
Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL (2015) (46)
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene (2001) (46)
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (2005) (45)
Cloning, mapping and characterization of the human RAB27A gene. (1999) (43)
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. (2004) (42)
The secretory small GTPase Rab27B as a marker for breast cancer progression (2010) (42)
CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice (2012) (42)
Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments. (2017) (39)
Clinical utility gene card for: Choroideremia (2013) (38)
Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms (2021) (37)
Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium (2014) (36)
Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux. (2008) (35)
Rab 27 a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes ✪ (2001) (35)
Transfer of extracellular vesicle‐microRNA controls germinal center reaction and antibody production (2020) (34)
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. (2009) (33)
Purification of ras farnesyl:Protein transferase (1990) (32)
A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases (2010) (31)
Adeno‐associated virus 8‐mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models (2014) (31)
Rab 38 and Rab 32 control post-Golgi traffi cking of melanogenic enzymes (2006) (30)
Are prenyl groups on proteins sticky fingers or greasy handles? (2003) (29)
Prenylation assays for small GTPases. (1998) (29)
Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. (1995) (29)
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease) (2015) (29)
Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding (2011) (28)
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. (2011) (28)
Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function (2011) (28)
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. (2008) (25)
Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes (2013) (25)
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models (2002) (25)
A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014) (25)
An essential role for Rab27a GTPase in eosinophil exocytosis (2013) (24)
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport (2009) (23)
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells (2016) (23)
Single prenyl-binding site on protein prenyl transferases. (1998) (23)
Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. (2011) (22)
Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives (2021) (22)
Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment (2012) (22)
Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1 (2019) (21)
A Family of Rab 27-binding Proteins (2002) (21)
Host PI(3,5)P2 Activity Is Required for Plasmodium berghei Growth During Liver Stage Infection (2014) (21)
Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. (2003) (20)
The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes (2020) (19)
Bacteria and Protozoa Differentially Modulate the Expression of Rab Proteins (2012) (18)
Nucleotide Dependence of Rab Geranylgeranylation Rab ESCORT PROTEIN INTERACTS PREFERENTIALLY WITH GDP-BOUND Rab* (1996) (17)
Loss of Rab27 function results in abnormal lung epithelium structure in mice (2010) (16)
Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex Transport Function (2011) (16)
Impact of the serum‐ and glucocorticoid‐inducible kinase 1 on platelet dense granule biogenesis and secretion (2015) (15)
cDNA Cloning and Chromosomal Localization of the Genes Encoding the α- and β-Subunits of Human Rab Geranylgeranyl Transferase: The 3′ End of the α-Subunit Gene Overlaps with the Transglutaminase 1 Gene Promoter ☆ (1996) (14)
A General Role for Rab 27 a in Secretory Cells (2003) (14)
Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs. (2012) (12)
The Role of Rab 27 a in the Regulation of Melanosome Distribution within Retinal Pigment Epithelial Cells (2004) (11)
The Ternary Rab 27 a – Myrip – Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium (2007) (11)
Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression (2018) (10)
Current methods to analyze lysosome morphology, positioning, motility and function (2022) (9)
Rab27a GTPase modulates L-type Ca2+ channel function via interaction with the II-III linker of CaV1.3 subunit. (2015) (9)
Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy (2013) (8)
Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) (7)
Correction: Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium (2013) (7)
Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease (2019) (7)
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue. (2012) (7)
A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes (2014) (7)
The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. (2011) (7)
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis (2004) (6)
Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a (2019) (6)
Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial (2018) (6)
Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography (2022) (5)
6 Biochemistry of Rab geranylgeranyltransferase (2001) (5)
p21ras farnesyltransferase: purification and properties of the enzyme. (1992) (5)
Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease‐activated receptor‐2 internalization (2022) (5)
Microenvironment and Immunology Rab 27 a Supports Exosome-Dependent and-Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression (2012) (5)
Melanin processing by keratinocytes: A non‐microbial type of host‐pathogen interaction? (2019) (5)
Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia (2020) (4)
Rab 3 GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab 27 a in Melanocytes * (2008) (4)
Choroideremia Mouse Model Generated by Conditional Rep1 Knock–Out (2005) (3)
Melanocore uptake by keratinocytes occurs through phagocytosis and involves Protease-activated receptor-2 activation (2021) (3)
cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. (1996) (3)
Persistent Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy (2010) (3)
Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer (2022) (2)
CORRELATION STUDY BETWEEN DRUSEN MORPHOLOGY AND FUNDUS AUTOFLUORESCENCE. (2020) (2)
Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes (2014) (2)
Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration (2021) (2)
A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014) (1)
Rab GTPases in membrane traffic and disease (2010) (1)
Validation and benchmarking of the Rabifier. (2011) (1)
Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia (2014) (1)
Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase. (2002) (1)
Long term vision results following retinal gene therapy for choroideremia (2016) (1)
Toluidine blue staining of skin sections (2007) (1)
The Secretory Small GTPase Rab27B Regulates Invasive Tumor Growth and Metastasis through Extracellular Heat Shock Protein 90α. (2009) (1)
Improved visual function in patients with choroideremia undergoing subretinal gene therapy (2014) (1)
Novel inflammatory biomarkers for clinical application (2010) (1)
Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells (2012) (1)
Rab3a regulates melanin exocytosis induced by keratinocyte-conditioned medium (2021) (1)
Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood. 2009;113(20):5010–5018. (2011) (1)
Preliminary X-ray structure analysis of Rab geranylgeranyl transferase (1996) (0)
Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise (2014) (0)
Rab27a is involved in bone formation by osteoblasts (2013) (0)
Choroideremia Zebrafish: A Model for Human Disease? (2007) (0)
Non-syndromic inherited retinal disease: choroideremia (2019) (0)
AMD-compatible lysosomal changes in Rab38-deficient mouse model (2014) (0)
Acute Responses to Inflammatory Stimuli Inhibits Chronic Inflammation and Enables Rab 27-Dependent Exosome Production (2017) (0)
Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts (2001) (0)
Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial (2012) (0)
Mechanisms of melanin transfer from melanocytes and formation of a parasol in keratinocytes (2016) (0)
Prediction of traqueal tube size in children using multiple variables: A-599 (2004) (0)
epithelium structure in mice Loss of Rab27 function results in abnormal lung (2011) (0)
AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells (2012) (0)
Eye Pigmentation Defect in Rab38-Deficient Chocolate Mice Results From the Short Time Frame of Melanogenesis in the Retinal Pigment Epithelium (2007) (0)
Table 2. [CHM Pathogenic Variants Discussed in This GeneReview]. (2015) (0)
GTPase activity of RAB5 as a timer for endocytic membrane fusion (1996) (0)
Myosin Va in regulated exocytosis of Weibel-Palade bodies (2010) (0)
Development of Persistently Expressing Vectors for the Non-Viral Gene Therapy of Choroideremia (2009) (0)
Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors (2012) (0)
Function of Rab27 proteins and implications for disease (2001) (0)
The role of Rab27 in intracellular transport (2002) (0)
CHM (Choroideremia) Gene (2002) (0)
BacteriaLong-Distance Vesicular Traffic or Surfing of between Human Macrophages Support Structurally Distinct Membrane Nanotubes (2006) (0)
Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium (2012) (0)
The Role of Rab GTPases in the Regulation of Melanosome Biogenesis and Motility in Retinal Pigment Epithelial Cells (2006) (0)
Table of Contents (1994) (0)
e ffect of the Secretory Small G t Pase r ab27B on Breast c ancer Growth, i nvasion, and Metastasis (2010) (0)
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (0)
Melanosome biogenesis, transport and function in retinal pigment epithelial cells (2008) (0)
Intracellular trafficking of melanosomes in the retinal pigmented epithelium: mapping of interactions between Rab27a, Myrip and MyoVIIa (2004) (0)
Prenylation Defect in the RPE Exacerbates Photoreceptor Degeneration in Choroideremia Mice (2009) (0)
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (0)
The Ternary Rab27a:Myrip:MyovIIa Complex Regulates Melanosome Tethering to the Actin Network (2007) (0)
Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles (2015) (0)
Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression (2018) (0)
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration (2022) (0)
Hyperpigmented epiretinal membrane in macular telangiectasia type 2: imaging characteristics and correlation with transretinal pigment migration. (2022) (0)
Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration (2019) (0)
Characterisation of the inhibition of rab prenylation by phosphonocarboxylates (2008) (0)
The Development of Non-Viral Vectors for Choroideremia (2012) (0)
PD7-12 HIGHLY COORDINATED DELIVERY OF UROPLAKIN PROTEINS TO THE APICAL UROTHELIAL CELL SURFACE (2015) (0)
Table 1. [Summary of Molecular Genetic Testing Used in Choroideremia]. (2015) (0)
RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium (2022) (0)
Uncovering the VEGF Secretory Pathway in Retinal Pigment Epithelium: the Rab Proteins’ Role (2012) (0)
Novel disease progression biomarkers in non-exudative age-related macular degeneration: an association study between drusen type and morphology and Fundus Autofluorescence. (2019) (0)
CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN (2000) (0)
Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes (2016) (0)
Mechanisms of photoreceptor degeneration in choroideremia (2014) (0)
Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia (2012) (0)
Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium (2015) (0)
Promote Tumor Progression Mechanisms That Modify the Tumor Microenvironment and Can Rab 27 a Supports Exosome-Dependent and-Independent (2012) (0)
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage (2023) (0)
Discovery of a novel inhibitor of RAB geranylgeranyl transferase that inhibits bone resorption by selectively preventing prenylation of RAB proteins in osteoclasts (2001) (0)
Correction of the Prenylation Defect in Choroideremia by Viral Delivery of the Choroideremia Gene (2009) (0)
Age-Related Changes of the Synucleins Profile in the Mouse Retina (2023) (0)
AAV vectors for use in gene therapy choroideremia (2012) (0)
Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction (2021) (0)
Rab8 is required for phagocytosis and phagosomal maturation (2011) (0)

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What Schools Are Affiliated With Miguel C. Seabra?

Miguel C. Seabra is affiliated with the following schools: