Miguel C. Seabra
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Physics
Miguel C. Seabra's Degrees
- PhD Physics University of Lisbon
- Masters Physics University of Lisbon
- Bachelors Physics University of Lisbon
Why Is Miguel C. Seabra Influential?
(Suggest an Edit or Addition)Miguel C. Seabra's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Rab27a and Rab27b control different steps of the exosome secretion pathway (2010) (1917)
- NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells (2006) (834)
- Evolution of the Rab family of small GTP-binding proteins. (2001) (784)
- Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides (1990) (701)
- Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial (2014) (697)
- Exosome-delivered microRNAs modulate the inflammatory response to endotoxin (2015) (566)
- The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. (2000) (479)
- Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. (2012) (477)
- Rab GTPases, intracellular traffic and disease. (2002) (475)
- The melanosome: membrane dynamics in black and white (2001) (441)
- Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria1 (2006) (414)
- Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes (2001) (412)
- 1 Rab 27 a and Rab 27 b control different steps of the exosome secretion pathway (2009) (391)
- MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells (2014) (351)
- Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes (2001) (328)
- GTPase activity of Rab5 acts as a timer for endocytic membrane fusion (1996) (326)
- cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein (1993) (314)
- Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. (1993) (313)
- Controlling the location and activation of Rab GTPases. (2004) (309)
- Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit (1991) (301)
- Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. (1992) (289)
- Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product (1992) (284)
- Membrane association and targeting of prenylated Ras-like GTPases. (1998) (276)
- Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases Published, JLR Papers in Press, January 9, 2006. (2006) (270)
- Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes (2006) (265)
- A Family of Rab27-binding Proteins (2002) (254)
- Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes (2007) (234)
- Rab escort protein‐1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. (1994) (234)
- Rab GTPases and Myosin Motors in Organelle Motility (2004) (222)
- Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia (*) (1995) (214)
- Melanosomes at a glance (2008) (208)
- Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. (2010) (189)
- Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease (2001) (185)
- Rab27b regulates number and secretion of platelet dense granules (2007) (177)
- Thousands of Rab GTPases for the Cell Biologist (2011) (176)
- MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells (2014) (165)
- REP-2, a Rab escort protein encoded by the choroideremia-like gene. (1994) (165)
- Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. (2002) (164)
- Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice* (2001) (162)
- A general role for Rab27a in secretory cells. (2003) (161)
- Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages* (2001) (159)
- Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. (2000) (157)
- The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes (2002) (155)
- Protein Prenyltransferases (*) (1996) (153)
- Membrane targeting of Rab GTPases is influenced by the prenylation motif. (2003) (146)
- Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (1994) (138)
- Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. (1991) (137)
- The melanosome as a model to study organelle motility in mammals. (2004) (136)
- Expression of the VLDL receptor in endothelial cells. (1996) (127)
- Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (120)
- Multiple regions contribute to membrane targeting of Rab GTPases (2004) (120)
- Fatty acylation and prenylation of proteins: what's hot in fat. (2005) (119)
- Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. (2006) (116)
- Rab27b Regulates Mast Cell Granule Dynamics and Secretion (2007) (112)
- Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience. (2018) (110)
- Visual Acuity after Retinal Gene Therapy for Choroideremia. (2016) (105)
- Mechanism of Digeranylgeranylation of Rab Proteins (1996) (104)
- Rab GTPases Containing a CAAX Motif Are Processed Post-geranylgeranylation by Proteolysis and Methylation* (2007) (102)
- Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis. (2014) (102)
- Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells (2009) (101)
- Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. (2000) (101)
- The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. (2004) (99)
- Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation (2010) (99)
- Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type (2003) (98)
- Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo. (2005) (97)
- A role for Rab27b in NF-E2-dependent pathways of platelet formation. (2003) (97)
- Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. (2001) (96)
- Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex. (1998) (94)
- Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. (2007) (93)
- Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms (2010) (92)
- Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes (2007) (91)
- The Ternary Rab27a–Myrip–Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium (2007) (91)
- Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). (1996) (85)
- Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. (2010) (84)
- Targeting of Rab GTPases to cellular membranes. (2005) (83)
- A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. (2006) (82)
- Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. (1991) (80)
- Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (79)
- Melanosomes on the move: a model to understand organelle dynamics. (2011) (76)
- A Family of Rab27-binding Proteins MELANOPHILIN LINKS Rab27a AND MYOSIN Va FUNCTION IN MELANOSOME TRANSPORT* (2002) (76)
- cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. (1993) (76)
- Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment (2015) (76)
- Novel functions for Rab GTPases in multiple aspects of tumour progression (2012) (75)
- Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von‐Willebrand Factor Release from Endothelial Cells (2011) (73)
- Multiple Factors Contribute to Inefficient Prenylation of Rab27a in Rab Prenylation Diseases* (2003) (73)
- A practical diagnostic test for choroideremia. (1998) (71)
- Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro. (1994) (70)
- Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13‐4 in mast cell secretion (2012) (67)
- Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli (2017) (66)
- PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. (2010) (65)
- Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. (2008) (64)
- Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics (2019) (63)
- New insights into the pathogenesis of choroideremia: a tale of two REPs. (1996) (61)
- Geranylgeranylation of Rab proteins. (1996) (61)
- ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. (2005) (60)
- Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. (2010) (57)
- Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes* (2008) (56)
- Rab and Arf Proteins in Genetic Diseases (2013) (54)
- Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus (2003) (53)
- Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase* (2009) (53)
- Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium (2013) (53)
- Host cell autophagy contributes to Plasmodium liver development (2016) (53)
- The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver Stage Development (2012) (50)
- Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry (2010) (50)
- Nucleotide Dependence of Rab Geranylgeranylation (1996) (48)
- Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL (2015) (46)
- Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene (2001) (46)
- The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (2005) (45)
- Cloning, mapping and characterization of the human RAB27A gene. (1999) (43)
- Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. (2004) (42)
- The secretory small GTPase Rab27B as a marker for breast cancer progression (2010) (42)
- CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice (2012) (42)
- Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments. (2017) (39)
- Clinical utility gene card for: Choroideremia (2013) (38)
- Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms (2021) (37)
- Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium (2014) (36)
- Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux. (2008) (35)
- Rab 27 a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes ✪ (2001) (35)
- Transfer of extracellular vesicle‐microRNA controls germinal center reaction and antibody production (2020) (34)
- Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. (2009) (33)
- Purification of ras farnesyl:Protein transferase (1990) (32)
- A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases (2010) (31)
- Adeno‐associated virus 8‐mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models (2014) (31)
- Rab 38 and Rab 32 control post-Golgi traffi cking of melanogenic enzymes (2006) (30)
- Are prenyl groups on proteins sticky fingers or greasy handles? (2003) (29)
- Prenylation assays for small GTPases. (1998) (29)
- Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. (1995) (29)
- Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease) (2015) (29)
- Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding (2011) (28)
- Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. (2011) (28)
- Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function (2011) (28)
- Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. (2008) (25)
- Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes (2013) (25)
- Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models (2002) (25)
- A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014) (25)
- An essential role for Rab27a GTPase in eosinophil exocytosis (2013) (24)
- Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport (2009) (23)
- Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells (2016) (23)
- Single prenyl-binding site on protein prenyl transferases. (1998) (23)
- Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. (2011) (22)
- Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives (2021) (22)
- Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment (2012) (22)
- Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1 (2019) (21)
- A Family of Rab 27-binding Proteins (2002) (21)
- Host PI(3,5)P2 Activity Is Required for Plasmodium berghei Growth During Liver Stage Infection (2014) (21)
- Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. (2003) (20)
- The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes (2020) (19)
- Bacteria and Protozoa Differentially Modulate the Expression of Rab Proteins (2012) (18)
- Nucleotide Dependence of Rab Geranylgeranylation Rab ESCORT PROTEIN INTERACTS PREFERENTIALLY WITH GDP-BOUND Rab* (1996) (17)
- Loss of Rab27 function results in abnormal lung epithelium structure in mice (2010) (16)
- Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex Transport Function (2011) (16)
- Impact of the serum‐ and glucocorticoid‐inducible kinase 1 on platelet dense granule biogenesis and secretion (2015) (15)
- cDNA Cloning and Chromosomal Localization of the Genes Encoding the α- and β-Subunits of Human Rab Geranylgeranyl Transferase: The 3′ End of the α-Subunit Gene Overlaps with the Transglutaminase 1 Gene Promoter ☆ (1996) (14)
- A General Role for Rab 27 a in Secretory Cells (2003) (14)
- Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs. (2012) (12)
- The Role of Rab 27 a in the Regulation of Melanosome Distribution within Retinal Pigment Epithelial Cells (2004) (11)
- The Ternary Rab 27 a – Myrip – Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium (2007) (11)
- Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression (2018) (10)
- Current methods to analyze lysosome morphology, positioning, motility and function (2022) (9)
- Rab27a GTPase modulates L-type Ca2+ channel function via interaction with the II-III linker of CaV1.3 subunit. (2015) (9)
- Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy (2013) (8)
- Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) (7)
- Correction: Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium (2013) (7)
- Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease (2019) (7)
- An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue. (2012) (7)
- A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes (2014) (7)
- The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. (2011) (7)
- Mouse genetic corneal disease resulting from transgenic insertional mutagenesis (2004) (6)
- Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a (2019) (6)
- Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial (2018) (6)
- Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography (2022) (5)
- 6 Biochemistry of Rab geranylgeranyltransferase (2001) (5)
- p21ras farnesyltransferase: purification and properties of the enzyme. (1992) (5)
- Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease‐activated receptor‐2 internalization (2022) (5)
- Microenvironment and Immunology Rab 27 a Supports Exosome-Dependent and-Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression (2012) (5)
- Melanin processing by keratinocytes: A non‐microbial type of host‐pathogen interaction? (2019) (5)
- Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia (2020) (4)
- Rab 3 GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab 27 a in Melanocytes * (2008) (4)
- Choroideremia Mouse Model Generated by Conditional Rep1 Knock–Out (2005) (3)
- Melanocore uptake by keratinocytes occurs through phagocytosis and involves Protease-activated receptor-2 activation (2021) (3)
- cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. (1996) (3)
- Persistent Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy (2010) (3)
- Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer (2022) (2)
- CORRELATION STUDY BETWEEN DRUSEN MORPHOLOGY AND FUNDUS AUTOFLUORESCENCE. (2020) (2)
- Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes (2014) (2)
- Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration (2021) (2)
- A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014) (1)
- Rab GTPases in membrane traffic and disease (2010) (1)
- Validation and benchmarking of the Rabifier. (2011) (1)
- Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia (2014) (1)
- Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase. (2002) (1)
- Long term vision results following retinal gene therapy for choroideremia (2016) (1)
- Toluidine blue staining of skin sections (2007) (1)
- The Secretory Small GTPase Rab27B Regulates Invasive Tumor Growth and Metastasis through Extracellular Heat Shock Protein 90α. (2009) (1)
- Improved visual function in patients with choroideremia undergoing subretinal gene therapy (2014) (1)
- Novel inflammatory biomarkers for clinical application (2010) (1)
- Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells (2012) (1)
- Rab3a regulates melanin exocytosis induced by keratinocyte-conditioned medium (2021) (1)
- Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood. 2009;113(20):5010–5018. (2011) (1)
- Preliminary X-ray structure analysis of Rab geranylgeranyl transferase (1996) (0)
- Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise (2014) (0)
- Rab27a is involved in bone formation by osteoblasts (2013) (0)
- Choroideremia Zebrafish: A Model for Human Disease? (2007) (0)
- Non-syndromic inherited retinal disease: choroideremia (2019) (0)
- AMD-compatible lysosomal changes in Rab38-deficient mouse model (2014) (0)
- Acute Responses to Inflammatory Stimuli Inhibits Chronic Inflammation and Enables Rab 27-Dependent Exosome Production (2017) (0)
- Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts (2001) (0)
- Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial (2012) (0)
- Mechanisms of melanin transfer from melanocytes and formation of a parasol in keratinocytes (2016) (0)
- Prediction of traqueal tube size in children using multiple variables: A-599 (2004) (0)
- epithelium structure in mice Loss of Rab27 function results in abnormal lung (2011) (0)
- AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells (2012) (0)
- Eye Pigmentation Defect in Rab38-Deficient Chocolate Mice Results From the Short Time Frame of Melanogenesis in the Retinal Pigment Epithelium (2007) (0)
- Table 2. [CHM Pathogenic Variants Discussed in This GeneReview]. (2015) (0)
- GTPase activity of RAB5 as a timer for endocytic membrane fusion (1996) (0)
- Myosin Va in regulated exocytosis of Weibel-Palade bodies (2010) (0)
- Development of Persistently Expressing Vectors for the Non-Viral Gene Therapy of Choroideremia (2009) (0)
- Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors (2012) (0)
- Function of Rab27 proteins and implications for disease (2001) (0)
- The role of Rab27 in intracellular transport (2002) (0)
- CHM (Choroideremia) Gene (2002) (0)
- BacteriaLong-Distance Vesicular Traffic or Surfing of between Human Macrophages Support Structurally Distinct Membrane Nanotubes (2006) (0)
- Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium (2012) (0)
- The Role of Rab GTPases in the Regulation of Melanosome Biogenesis and Motility in Retinal Pigment Epithelial Cells (2006) (0)
- Table of Contents (1994) (0)
- e ffect of the Secretory Small G t Pase r ab27B on Breast c ancer Growth, i nvasion, and Metastasis (2010) (0)
- Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia (2018) (0)
- Melanosome biogenesis, transport and function in retinal pigment epithelial cells (2008) (0)
- Intracellular trafficking of melanosomes in the retinal pigmented epithelium: mapping of interactions between Rab27a, Myrip and MyoVIIa (2004) (0)
- Prenylation Defect in the RPE Exacerbates Photoreceptor Degeneration in Choroideremia Mice (2009) (0)
- Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo (2013) (0)
- The Ternary Rab27a:Myrip:MyovIIa Complex Regulates Melanosome Tethering to the Actin Network (2007) (0)
- Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles (2015) (0)
- Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression (2018) (0)
- Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration (2022) (0)
- Hyperpigmented epiretinal membrane in macular telangiectasia type 2: imaging characteristics and correlation with transretinal pigment migration. (2022) (0)
- Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration (2019) (0)
- Characterisation of the inhibition of rab prenylation by phosphonocarboxylates (2008) (0)
- The Development of Non-Viral Vectors for Choroideremia (2012) (0)
- PD7-12 HIGHLY COORDINATED DELIVERY OF UROPLAKIN PROTEINS TO THE APICAL UROTHELIAL CELL SURFACE (2015) (0)
- Table 1. [Summary of Molecular Genetic Testing Used in Choroideremia]. (2015) (0)
- RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium (2022) (0)
- Uncovering the VEGF Secretory Pathway in Retinal Pigment Epithelium: the Rab Proteins’ Role (2012) (0)
- Novel disease progression biomarkers in non-exudative age-related macular degeneration: an association study between drusen type and morphology and Fundus Autofluorescence. (2019) (0)
- CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN (2000) (0)
- Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes (2016) (0)
- Mechanisms of photoreceptor degeneration in choroideremia (2014) (0)
- Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia (2012) (0)
- Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium (2015) (0)
- Promote Tumor Progression Mechanisms That Modify the Tumor Microenvironment and Can Rab 27 a Supports Exosome-Dependent and-Independent (2012) (0)
- Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage (2023) (0)
- Discovery of a novel inhibitor of RAB geranylgeranyl transferase that inhibits bone resorption by selectively preventing prenylation of RAB proteins in osteoclasts (2001) (0)
- Correction of the Prenylation Defect in Choroideremia by Viral Delivery of the Choroideremia Gene (2009) (0)
- Age-Related Changes of the Synucleins Profile in the Mouse Retina (2023) (0)
- AAV vectors for use in gene therapy choroideremia (2012) (0)
- Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction (2021) (0)
- Rab8 is required for phagocytosis and phagosomal maturation (2011) (0)
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