Mika Scheinin

Q: What Schools Are Affiliated With Mika Scheinin

Mika Scheinin is affiliated with the following schools: University of Turku, Karolinska Institute, University of Duisburg-Essen

Mika Scheinin's AcademicInfluence.com Rankings

Mika Scheinin

Psychology

#2844

World Rank

#3268

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psychology Degrees

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Psychology

Mika Scheinin's Degrees

PhD Psychology University of Helsinki
Masters Psychology University of Helsinki

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Mika Scheinin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. (1983) (1309)
Different metabolic responses of human brown adipose tissue to activation by cold and insulin. (2011) (630)
Distribution of α2-adrenergic receptor subtype gene expression in rat brain (1994) (388)
PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment (2007) (325)
Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl. (1992) (314)
Postoperative Pharmacokinetics and Sympatholytic Effects of Dexmedetomidine (1997) (305)
Gene targeting — homing in on α2-adrenoceptor-subtype function (1997) (304)
Dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. (1990) (297)
Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep (2008) (268)
Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy (2008) (254)
Effects of dexmedetomidine, a selective α2‐adrenoceptor agonist, on hemodynamic control mechanisms (1989) (250)
Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. (1983) (249)
Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) (242)
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls. (1984) (208)
CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients. (1984) (207)
Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. (1992) (193)
Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6‐hydroxydopamine and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (2003) (188)
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice (1998) (185)
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant (2004) (181)
Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system. (1995) (163)
Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist (1997) (154)
Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. (1994) (152)
Bioavailability of dexmedetomidine after intranasal administration (2011) (150)
Effects of Low and High Plasma Concentrations of Dexmedetomidine on Myocardial Perfusion and Cardiac Function in Healthy Male Subjects (2006) (139)
Alpha2‐adrenergic agents in anaesthesia (1993) (138)
Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers. (1987) (132)
Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. (1995) (128)
Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. (1988) (127)
Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients. (2012) (127)
Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls (2009) (124)
Selective antidepressants and cerebrospinal fluid. Lack of specificity on norepinephrine and serotonin metabolites. (1985) (124)
Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. (1997) (123)
Medetomidine — a novel α2-adrenoceptor agonist: A review of its pharmacodynamic effects (1989) (122)
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels (1999) (120)
Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. (1983) (118)
Reduction of pain at venous cannulation in children with a eu tec tic mixture of lidocaine and prilocaine (EMLA® cream): comparison with placebo cream and no local premedication (1987) (115)
Dexmedetomidine Premedication for Minor Gynecologic Surgery (1990) (113)
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. (1999) (112)
Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age. (2008) (107)
α2-adrenoceptor regulation of blood glucose homeostasis. (2011) (107)
Haemodynamic and catecholamine responses to induction of anaesthesia and tracheal intubation: comparison between propofol and thiopentone. (1993) (106)
Behavioural and neurochemical effects of antipamezole, a novel α2-adrenoceptor antagonist (1988) (106)
An insertion/deletion polymorphism in the α2b-adrenergic receptor gene is a novel genetic risk factor for acute coronary events☆ (2001) (105)
Rapid and simple determination of homovanillic acid in plasma using high performance liquid chromatography with electrochemical detection. (2009) (105)
Oral premedication with clonidine: effects on stress responses during general anaesthesia (1987) (105)
Liquid chromatographic assay for CSF catecholamines using electrochemical detection. (1984) (104)
Molecular pharmacology of α2-adrenoceptor subtypes (1995) (104)
Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction. (2006) (102)
Sedative and cardiovascular effects of medetomidine, a novel selective alpha 2-adrenoceptor agonist, in healthy volunteers. (1987) (101)
Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice (2002) (101)
Variation in the alpha2B-adrenoceptorgene as a risk factor for prehospitalfatal myocardial infarction and sudden cardiac death (2003) (101)
Influence of hydroxychloroquine on the bioavailability of oral metoprolol. (2000) (97)
Effects of esmolol on haemodynamic response to CO2 pneumoperitoneum for laparoscopic surgery (1998) (96)
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial☆☆☆ (2016) (96)
Measurement of 3-methoxy-4-hydroxyphenylglycol in human plasma with high-performance liquid chromatography using electrochemical detection. (1983) (95)
Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers. (1991) (94)
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase. (1997) (91)
α2-Adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the α2A-adrenoceptor subtype (2003) (85)
Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist. (1991) (85)
Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine (1992) (83)
d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α 2C-adrenergic receptor subtype (1998) (80)
Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells. (1994) (79)
Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models. (2001) (77)
A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery. (1991) (77)
The Locus Coeruleus Site of Hypnotic Actions of α2-Adrenoceptor Agonists? (1992) (76)
Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers. (1989) (76)
Behavioural and neurochemical effects of atipamezole, a novel α2-adreneceptor antagonist (1988) (75)
Randomized comparison of the neuroendocrine response to laparoscopic cholecystectomy using either conventional or abdominal wall lift techniques (1996) (73)
Expression and function of α2‐adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions (2005) (73)
Longitudinal Amyloid Imaging in Mouse Brain with 11C-PIB: Comparison of APP23, Tg2576, and APPswe-PS1dE9 Mouse Models of Alzheimer Disease (2013) (71)
ALFENTANIL OBTUNDS THE CARDIOVASCULAR AND SYMPATHOADRENAL RESPONSES TO SUXAMETHONIUM-FACILITATED LARYNGOSCOPY AND INTUBATION (1989) (69)
A Comparison of Gasless Mechanical and Conventional Carbon Dioxide Pneumoperitoneum Methods for Laparoscopic Cholecystectomy (1998) (68)
Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. (2004) (67)
Effects of common polymorphisms in the α1A-, α2B-, β1- and β2-adrenoreceptors on haemodynamic responses to adrenaline (2003) (67)
An introduction to the pharmacology of alpha 2-adrenoceptors in the central nervous system. (1989) (67)
Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. (1991) (67)
Recombinant human alpha 2-adrenoceptor subtypes: comparison of [3H]rauwolscine, [3H]atipamezole and [3H]RX821002 as radioligands. (1995) (66)
Conserved structural, pharmacological and functional properties among the three human and five zebrafish α2‐adrenoceptors (2005) (65)
Use of recombinant human α2-adrenoceptors to characterize subtype selectivity of antagonist binding (1993) (64)
Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma catecholamines, heart rate and blood pressure. (1988) (62)
Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. (2001) (62)
Receptor Subtype-Induced Targeting and Subtype-Specific Internalization of Human α2-Adrenoceptors in PC12 Cells (1999) (61)
Adrenergic α2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry (1999) (61)
Octopamine Receptors from the Barnacle Balanus improvisus Are Activated by the α2-Adrenoceptor Agonist Medetomidine (2010) (59)
Application of cross-species PET imaging to assess neurotransmitter release in brain (2015) (58)
Assessment of MAO‐B Occupancy in the Brain With PET and [11C]‐L‐Deprenyl‐D2: A Dose‐Finding Study With a Novel MAO‐B Inhibitor, EVT 301 (2009) (58)
Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. (2003) (57)
Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients (1985) (57)
CSF neurochemistry of women with anorexia nervosa and normal women. (1984) (57)
Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its pharmacodynamic effects. (1989) (56)
Nonradioactive GTP binding assay to monitor activation of g protein-coupled receptors. (2003) (55)
Regulation of α2A-adrenoceptor expression by chronic stress in neurons of the brain stem (2000) (55)
Lack of adverse interactions between concomitantly administered selegiline and citalopram. (1997) (55)
Regional distribution of α2C-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the α2C-subtype: an autoradiographic study with [3H]RX821002 and [3H]rauwolscine (2003) (54)
Pharmacokinetics of [18F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer’s disease (2012) (54)
Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns (1999) (53)
Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies. (1998) (53)
Effects of oral clonidine premedication on concentrations of Cortisol and monoamine neurotransmitters and their metabolites in cerebrospinal fluid and plasma (1989) (53)
Monoamine metabolites in human cerebrospinal fluid: indicators of neuronal activity? (1985) (52)
Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2-adrenoceptor antagonist--a randomized, double-blind cross-over study in healthy male volunteers. (1990) (52)
&agr;2A Adrenoceptors Contribute to Feedback Inhibition of Capsaicin-induced Hyperalgesia (2004) (51)
QT dispersion after subarachnoid hemorrhage. (1999) (51)
G-protein beta3 subunit C825T polymorphism: no association with risk for hypertension and obesity. (2001) (51)
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. (1997) (51)
Overexpression of Alpha2C-adrenoceptors impairs water maze navigation (1999) (50)
Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs (2012) (50)
Alpha2A-Adrenoceptors are Important Modulators of the Effects of D-Amphetamine on Startle Reactivity and Brain Monoamines (2004) (49)
Inhibition of α-adrenergic tone disturbs the distribution of blood flow in the exercising human limb. (2013) (49)
Propofol infusion for sedation in outpatient oral surgery (1989) (49)
Assessing the depth of dexmedetomidine‐induced sedation with electroencephalogram (EEG)‐based spectral entropy (2007) (49)
An insertion/deletion polymorphism in the alpha2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events. (2001) (47)
Altered glucose homeostasis in α2A-adrenoceptor knockout mice (2004) (46)
Reduced blood glucose levels, increased insulin levels and improved glucose tolerance in alpha2A-adrenoceptor knockout mice. (2008) (46)
Subtype-specific stimulation of []GTPγS binding by recombinant α2-adrenoceptors (1998) (46)
Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study (2016) (45)
A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease. (2021) (44)
Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine. (2013) (44)
Reliability of norepinephrine and major monoamine metabolite measurements in CSF of schizophrenic patients. (1983) (44)
Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study. (2019) (42)
Differential expression of two α2-adrenergic receptor subtype mRNAs in human tissues (1992) (42)
CYP2A6 genetic variation and dexmedetomidine disposition (2012) (42)
Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers. (2011) (42)
Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice. (2002) (41)
Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (2003) (40)
Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. (2003) (40)
Anaesthesia affects plasma concentrations of vasopressin, von Willebrand factor and coagulation factor VIII in cardiac surgical patients. (1993) (40)
Cloning and expression of a fish α2‐adrenoceptor (1993) (39)
α2A‐Adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice (2008) (38)
Ethnic and Genetic Determinants of Cardiovascular Response to the Selective &agr;2-Adrenoceptor Agonist Dexmedetomidine (2008) (38)
Determination of erythromycin base and 2'-acetylerythromycin in human plasma using high-performance liquid chromatography with electrochemical detection. (1990) (36)
The involvement of α2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice (2004) (36)
A comparison of gasless mechanical and conventional carbon dioxide pneumoperitoneum methods for laparoscopic cholecystectomy. (1998) (36)
Disposition of single oral doses of E‐10‐hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects (1986) (36)
Phenoxybenzamine Binding Reveals the Helical Orientation of the Third Transmembrane Domain of Adrenergic Receptors* (2001) (36)
Regulation of alpha(2A)-adrenoceptor expression by chronic stress in neurons of the brain stem. (2000) (35)
Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects (2015) (35)
Molecular mechanisms of ligand–receptor interactions in transmembrane domain V of the α2A‐adrenoceptor (2003) (35)
Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. (2002) (35)
Molecular pharmacology of alpha 2-adrenoceptor subtypes. (1995) (35)
Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases. (2004) (34)
Characterization of [3H]atipamezole as a radioligand for α2-adrenoceptors (1992) (34)
Antenatal and Early Postnatal Dexamethasone Treatment Decreases Cortisol Secretion in Preterm Infants (2000) (33)
Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2 -adrenoceptor antagonist MK-467 in horses. (2016) (32)
Differential effects of clorgyline on catecholamine and indoleamine metabolites in the cerebrospinal fluid of rhesus monkeys. (1984) (32)
Chloroethylclonidine binds irreversibly to exposed cysteines in the fifth membrane-spanning domain of the human alpha2A-adrenergic receptor. (1998) (32)
Intramuscular dexmedetomidine, a novel alpha2‐ adrenoceptor agonist, as premedication for minor gynaecological surgery (1991) (32)
Alfentanil obtunds the cardiovascular and sympathoadrenal responses to suxamethonium-facilitated laryngoscopy and intubation. (1990) (31)
Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. (2009) (31)
Single dose pharmacokinetics of doxepin in healthy volunteers. (2009) (31)
Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice. (2004) (31)
Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice. (2003) (31)
Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors. (1998) (30)
The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. (1993) (30)
Reduction of norepinephrine turnover by serotonergic drug in man. (1984) (30)
The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene. (2006) (30)
Effects of variation in the human α2A‐ and α2C‐adrenoceptor genes on cognitive tasks and pain perception (2010) (29)
Determinants of coronary flow velocity reserve in healthy young men. (2006) (29)
Sympatho-adrenal activity and the clinical sedative effect of detomidine in horses. (2010) (29)
Loss of amitriptyline analgesia in α2A-adrenoceptor deficient mice (2004) (29)
Effect of single and repeated doses of activated charcoal on the pharmacokinetics of doxepin. (1985) (29)
Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study. (2019) (28)
alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice. (2005) (28)
COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. (1994) (28)
Effect of &agr;2B-Adrenoceptor Polymorphism on Peripheral Vasoconstriction in Healthy Volunteers (2005) (28)
The locus coeruleus. Site of hypnotic actions of alpha 2-adrenoceptor agonists? (1992) (28)
Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol (2015) (28)
Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptors. (2002) (28)
Application of radioreceptor assay of benzodiazepines for toxicology. (2009) (28)
Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects (2019) (27)
Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands. (2005) (27)
Association between increased serotonin metabolism in rat brainstem nuclei and development of spontaneous hypertension (1986) (27)
Stable expression of recombinant human alpha 2-adrenoceptor subtypes in two mammalian cell lines: characterization with [3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay. (1992) (27)
Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data (2009) (27)
Alpha2-adrenoceptor agonists stimulate high-affinity GTPase activity in a receptor subtype-selective manner. (1999) (27)
alpha 2-Adrenoceptor agonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid. (1986) (27)
Effects of electroconvulsive treatment on monoamine metabolites, growth hormone, and prolactin in plasma. (1984) (27)
The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception. (2003) (26)
Haemodynamic and catecholamine responses to induction of anaesthesia and tracheal intubation in diabetic and non-diabetic uraemic patients. (1995) (26)
Detomidine reduces the plasma catecholamine, but not cortisol concentrations in horses. (1991) (26)
Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry. (1999) (25)
Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha(2C)-subtype: an autoradiographic study with [(3)H]RX821002 and [(3)H]rauwolscine. (2003) (25)
Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation. (2004) (25)
Factors associated with post-operative myocardial ischaemia in elderly patients undergoing major non-cardiac surgery. (1999) (25)
In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol (2014) (25)
The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine (1995) (25)
Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients (2020) (25)
Genetic Variations in the &agr;2A-Adrenoreceptor Are Associated With Blood Pressure Response to the Agonist Dexmedetomidine (2011) (24)
Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs. (2017) (24)
The second extracellular loop of α2A‐adrenoceptors contributes to the binding of yohimbine analogues (2007) (24)
Functional expression and direct visualization of the human α2B-adrenergic receptor and α2B-AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors (2003) (24)
Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane. (2015) (24)
Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods (2006) (24)
Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition (1999) (24)
Biological correlates of mental stress related to anticipated caesarean section (1990) (23)
Exercise hemodynamics and catecholamine metabolism after catechol‐O‐methyltransferase inhibition with nitecapone (1990) (23)
A PET Tracer for Brain α2C Adrenoceptors, 11C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice (2014) (23)
Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs. (2016) (23)
Effects of short-term thermal stress on plasma catecholamine concentrations and plasma renin activity in pregnant and nonpregnant women. (1992) (23)
Agonist-dependent trafficking of alpha2-adrenoceptor subtypes: dependence on receptor subtype and employed agonist. (2003) (23)
Effects of dexmedetomidine on coronary hemodynamics and myocardial oxygen balance. (1996) (22)
Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves. (2011) (22)
Therapeutic applications of drugs acting on alpha-adrenoceptors. (1988) (22)
Repetitive measurement of monoamine metabolite levels in cerebrospinal fluid of conscious rats: effects of reserpine and haloperidol. (1985) (22)
Antenatal Dexamethasone Treatment Decreases Plasma Catecholamine Levels in Preterm Infants (1998) (22)
Foundations of Human Consciousness: Imaging the Twilight Zone (2020) (21)
Enalaprilat in acute intractable heart failure after myocardial infarction: A prospective, consecutive sample, before‐after trial (1994) (21)
Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. (1988) (21)
Sympatho‐adrenal and pituitary hormone responses during and immediately after thoracic surgery ‐ modulation by four different pain treatments (1987) (21)
Spinal fluid monoamine metabolites and anti-cytomegalovirus antibodies and brain scan evaluation in schizophrenia. (1984) (21)
Determination of conjugated dopamine in cerebrospinal fluid from humans and non-human primates with high performance liquid chromatography using electrochemical detection. (1984) (21)
The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure (2017) (20)
11C-ORM-13070, a novel PET ligand for brain α2C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men (2014) (20)
Effects of monoamine oxidase inhibition by selegiline on concentrations of noradrenaline and monoamine metabolites in CSF of patients with Alzheimer's disease (1993) (20)
Effects of feedborne fusarium mycotoxins on brain regional neurochemistry of turkeys. (2008) (20)
Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: lack of interactions (1996) (20)
Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression (2019) (19)
Evidence that the reversible MAO-A inhibitor moclobemide increases prolactin secretion by a serotonergic mechanism in healthy male volunteers. (1990) (19)
Comparison of free MHPG in rat cerebrospinal fluid with free and conjugated MHPG in brain tissue: effects of drugs modifying noradrenergic transmission. (1986) (19)
Rifampicin markedly decreases the exposure to oral and intravenous tramadol (2013) (19)
Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease (2016) (19)
Behavioural and neurochemical effects of antipamezole, a novel alpha 2-adrenoceptor antagonist. (1988) (18)
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction (2013) (18)
The diet board: welfare impacts of a novel method of dietary restriction in laboratory rats (2009) (18)
Acute Hemodynamic Effects of Medetomidine and Clonidine in Healthy Volunteers: A Noninvasive Echocardiographic Study (1990) (18)
Morphine-induced cardiovascular stimulation: the effects of two doses on healthy subjects. (2000) (18)
The insertion/deletion variation in the α2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes (2003) (18)
The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. (2004) (18)
Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain (2015) (18)
Test–retest reliability of 11C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain (2014) (18)
Subcutaneously administered dexmedetomidine is efficiently absorbed and is associated with attenuated cardiovascular effects in healthy volunteers (2018) (18)
3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor. (2011) (17)
Enalapril Premedication Attenuates the Blood Pressure Response to Tracheal Intubation and Stabilizes Postoperative Blood Pressure after Controlled Hypotension with Sodium Nitroprusside in Neurovascular Patients (1993) (17)
Molecular pharmacology of alpha2-adrenoceptor agonists (2000) (17)
Homogeneous GTP Binding Assay Employing QRET Technology (2010) (17)
Effects of dexmedetomidine on coronary hemodynamics and myocardial oxygen balance (1995) (17)
Hormonal responses to physical exercise in patients with polycystic ovarian syndrome. (1993) (17)
Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction (2005) (16)
Immunoaffinity purification and reconstitution of human alpha(2)-adrenergic receptor subtype C2 into phospholipid vesicles. (2001) (16)
Role of alpha2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha2C-adrenoceptor gene. (1999) (16)
Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist. (1993) (16)
Involvement of α2-Adrenoceptor Subtypes A and C in Glucose Homeostasis and Adrenaline-Induced Hyperglycaemia (2012) (16)
Neurotransmission and the experience of low back pain; no association between csf monoamine metabolites and pain (1985) (16)
Epidural and paracervical blockades in obstetrics. Catecholamines, arginine vasopressin and analgesic effect. (1986) (16)
Tetrahydrobiopterin administration to rhesus macaques. Its appearance in CSF and effect on neurotransmitter synthesis. (1986) (16)
Biochemical assessment of preoperative stress: a study with diazepam and measurement of monoamine metabolites and catecholamines in cerebrospinal fluid and plasma. (1991) (16)
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. (2008) (16)
Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions. (1998) (15)
[Ethyl-3H]RS-79948-197 α2-adrenoceptor autoradiography validation in α2-adrenoceptor knockout mice (2004) (15)
Spatial working memory improvement by an α2-adrenoceptor agonist dexmedetomidine is not mediated through α2C-adrenoceptor (2001) (15)
Molecular pharmacology of alpha 2 - adrenoceptor agonists (2000) (15)
Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease. (2011) (15)
Electroencephalographic Burst Suppression Versus Loss of Reflexes Anesthesia with Propofol or Thiopental: Differences of Variance in the Catecholamine and Cardiovascular Response to Tracheal Intubation (2003) (15)
Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (2004) (15)
Validation of [11C]ORM‐13070 as a PET tracer for alpha2c‐adrenoceptors in the human brain (2015) (15)
Alpha2C-adrenoceptor mediated regulation of cortical EEG arousal (2002) (15)
Nonadrenergic Binding of [3H]Atipamezole in Rat Lung (1995) (14)
The α2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization (2003) (13)
Involvement of the first transmembrane segment of human α2‐adrenoceptors in the subtype‐selective binding of chlorpromazine, spiperone and spiroxatrine (2011) (13)
Development of a scintiplate assay for recombinant human α2B-adrenergic receptor (2002) (13)
Safety, Biodistribution, and Radiation Dosimetry of 18F-rhPSMA-7.3 in Healthy Adult Volunteers (2020) (13)
Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini* (2016) (13)
Blood pressure regulation and cardiac autonomic control in mice overexpressing α- and γ-melanocyte stimulating hormone (2008) (13)
Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities. (2014) (13)
The impact of MK‐467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal (2018) (13)
No involvement of α 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men (1990) (13)
[PP.02.17] SUCCESSFUL COMPLETION OF A PHASE I, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, SINGLE ASCENDING DOSE TRIAL FOR THE FIRST IN CLASS ANGIOTENSIN AT2-RECEPTOR AGONIST COMPOUND 21 (2017) (13)
Pharmacokinetics and safety of deramciclane during multiple oral dosing. (1999) (12)
Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells. (2005) (12)
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. (2016) (12)
Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors. (2003) (12)
Medetomidine premedication in dental surgery ‐ a double‐blind cross‐over study with a new α2‐adrenoceptor agonist (1990) (12)
Sympathoadrenal activity in preterm infants during the first five days of life. (1992) (12)
Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. (2004) (12)
Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS – a PET study in human subjects (2015) (12)
Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route (2014) (12)
Effect of propranolol on monoamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia (1984) (11)
Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines. (2012) (11)
Wound Healing in Denervated Rat Groin Skin Flap (2000) (11)
Non‐adrenergic binding of [3H]atipamezole in rat kidney–regional distribution and comparison to α2‐adrenoceptors (1999) (11)
Use of recombinant human alpha 2-adrenoceptors to characterize subtype selectively of antagonist binding. (1993) (11)
Effects of chronic desipramine on plasma norepinephrine concentrations and cardiovascular parameters in elderly depressed women: a preliminary report. (1984) (11)
Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene (2013) (11)
Constitutive precoupling to Gi and increased agonist potency in the α2B-adrenoceptor (2003) (11)
Evaluation of the α2C-adrenoceptor as a neuropsychiatric drug target (2001) (11)
Apomorphine does not lower the concentration of homovanillic acid in the plasma of normal humans. (1984) (11)
Detecting a dexmedetomidine‐evoked reduction of noradrenaline release in the human brain with the alpha2C‐adrenoceptor PET ligand [11C]ORM‐13070 (2016) (11)
Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant‐rate medetomidine infusion in standing horses (2019) (11)
Pharmacological effects of medetomidine in humans. (1989) (11)
Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies. (2016) (11)
Tryptophan and biogenic amine metabolites in post-mortem human cisternal fluid: Effects of post-mortem interval and agonal time (1992) (10)
Ligand Recognition of Serine—Cysteine Amino Acid Exchanges in Transmembrane Domain 5 of α2‐Adrenergic Receptors by UK 14,304 (2000) (10)
Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo (2013) (10)
Safety, Tolerability, and Antihypertensive Effect of SER100, an Opiate Receptor‐Like 1 (ORL‐1) Partial Agonist, in Patients With Isolated Systolic Hypertension (2017) (10)
α2C-Adrenoceptors modulate the effect of methylphenidate on response rate and discrimination accuracy in an operant test (2001) (10)
Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man. (1998) (10)
Effects of the α2-adrenoceptor agonist medetomidine on the distribution and clearance of alfaxalone during coadministration by constant rate infusion in dogs. (2017) (10)
Peripheral α2-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs. (2018) (10)
Variation in the &agr;2A adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose (2013) (10)
Enalaprilat decreases plasma endothelin and atrial natriuretic peptide levels and preload in patients with left ventricular dysfunction after cardiac surgery. (1997) (9)
Effects of the peripherally acting α2-adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated by intramuscular administration of medetomidine and ketamine and reversed by intramuscular administration of atipamezole. (2018) (9)
Single-dose and steady-state pharmacokinetics of ospemifene, a selective estrogen receptor modulator, in postmenopausal women. (2013) (9)
Cardiovascular effects of premedication with medetomidine alone and in combination with MK-467 or glycopyrrolate in dogs subsequently anesthetized with isoflurane. (2017) (9)
Potentiation of Glibenclamide Hypoglycaemia in Mice by MK‐467, a Peripherally Acting Alpha2‐Adrenoceptor Antagonist (2015) (9)
Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues. (1992) (9)
Presynaptic dopamine receptors in the pithed rat: characterization with apomorphine and comparison with central dopamine autoreceptors. (2009) (9)
Similar ligand binding in recombinant human α2C2-adrenoceptors produced in mammalian, insect and yeast cells (1994) (9)
Meptazinol and pentazocine: plasma catecholamines and other effects in healthy volunteers. (1987) (9)
Mode of delivery, plasma catecholamines and Doppler-derived cardiac output in healthy term newborn infants. (1992) (9)
Identification of a novel 12-nucleotide insertion polymorphism in the promoter region of ADRA2B: full linkage with the 9-nucleotide deletion in the coding region and influence on transcriptional activity. (2010) (9)
Tolerability and effects of atipamezole, a novel alpha2-adrenoceptor antagonist, in healthy male volunteers: an open dose-finding study (1989) (9)
Oral bioavailability of ospemifene improves with food intake. (2013) (9)
Sedative Plasma Concentrations and Delirium Risk in Critical Illness (2018) (9)
G-protein β3 subunit C825T polymorphism: no association with risk for hypertension and obesity (2001) (8)
Cloning and expression of a fish alpha 2-adrenoceptor. (1993) (8)
Comparison of APP23, Tg2576, and APP swe -PS1 dE9 Mouse Models of Alzheimer Disease (2013) (8)
Might the observed α(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? (2012) (8)
Effects of Intravenous and Subcutaneous Administration of Apomorphine on the Clinical Symptoms of Chronic Schizophrenics (1986) (8)
Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells (2017) (8)
Radioimmunoassay for doxepin and desmethyldoxepin. (2009) (8)
A comparison of two sedative premedications for minor oral surgery under local anaesthesia. (1989) (8)
Tetrahydrobiopterin administration to rhesus macaques (1986) (8)
Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor. (2003) (8)
Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma. (1987) (7)
High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors. (2012) (7)
Placental and blood-CSF transfer of intramuscularly administered atropine in the same person. (1987) (7)
Plasma levels of atrial natriuretic peptide and endothelin-1 in experimental fat embolism. (1997) (7)
Effects of apomorphine on blood levels of homovanillic acid, growth hormone and prolactin in medicated schizophrenics and heatlhy control subjects (1985) (7)
Uneven cellular expression of recombinant alpha2A-adrenoceptors in transfected CHO cells results in loss of response in adenylyl cyclase inhibition. (2005) (7)
Norepinephrine metabolites in plasma as indicators of pharmacological inhibition of monoamine oxidase and catechol O-methyltransferase. (1998) (7)
Dose-finding and tolerability study of medetomidine in four healthy volunteers: an open phase-I investigation (1987) (7)
Improved high-performance liquid chromatographic method for the routine determination of unconjugated 3-methoxy-4-hydroxyphenylethyleneglycol in human plasma using solid-phase extraction and electrochemical detection. (1991) (7)
Dorsal hand vein responses to the α₁-adrenoceptor agonist phenylephrine do not predict responses to the α₂-adrenoceptor agonist dexmedetomidine. (2011) (7)
Expression and characterization of the human alpha 2B-adrenoceptor in a vascular smooth muscle cell line. (2008) (7)
Placental and blood-CSF transfer of orally administered diazepam in the same person. (1987) (7)
Assessment of α2-adrenoceptor antagonist potency with GTPase assay (1997) (7)
Effect of low-dose propofol infusion on total-body oxygen consumption after coronary artery surgery. (1999) (6)
alpha 2B-Adrenoceptor levels govern agonist and inverse agonist responses in PC12 cells. (2003) (6)
Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans (1990) (6)
A polymorphism in the protein kinase C gene PRKCB is associated with &agr;2-adrenoceptor-mediated vasoconstriction (2013) (6)
Amino Acid Plasma Profiles from a Prolonged-Release Protein Substitute for Phenylketonuria: A Randomized, Single-Dose, Four-Way Crossover Trial in Healthy Volunteers (2020) (6)
DEXMEDETOMIDINE REDUCES THIOPENTAL ANESTHETIC REQUIREMENTS IN MAN (1989) (6)
Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors (2018) (6)
Decreased Spinal Fluid Monoamine Metabolites and Norepinephrine in Schizophrenic Patients with Brain Atrophy (1985) (6)
Hemodynamic effects of dexmedetomidine in anesthetized dogs and their antagonism by ATP (1990) (6)
DEXMEDETOMIDINE REDUCES INTRAOCULAR PRESSURE, INTUBATION RESPONSES AND ANESTHETIC REQUIREMENTS IN OPHTHALMIC SURGERY (1991) (6)
Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report (2010) (6)
Evaluation of the systemic anticholinergic activity of nasally administered ipratropium bromide. (1988) (6)
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice. (2004) (6)
Determination of maprotiline and N-desmethylmaprotiline from biological fluids by HPLC. (1983) (6)
Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model. (2018) (5)
Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor. (2001) (5)
Premedication with intranasal dexmedetomidine decreases barbiturate requirement in pediatric patients sedated for magnetic resonance imaging: a retrospective study (2018) (5)
Tofisopam and midazolam: differences in clinical effects and in changes of CSF monoamine metabolites. (1985) (5)
Effects of nortriptyline and its 10-hydroxy metabolite on plasma noradrenaline (NA) concentrations, heart rate and blood pressure during intravenous NA infusion. (1987) (5)
Investigation of the effects of vatinoxan on somatic and visceral antinociceptive efficacy of medetomidine in dogs. (2020) (5)
Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component. (2010) (5)
Kinetic analysis and optimisation of 18F-rhPSMA-7.3 PET imaging of prostate cancer (2021) (5)
Development of a scintiplate assay for recombinant human alpha(2B)-adrenergic receptor. (2002) (4)
Alterations in peripheral and central dopamine receptor sensitivity after subchronic treatment with fluphenazine and sulpiride. (1987) (4)
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers (2005) (4)
beta-blockade, atrial natriuretic peptide and exercise. (1996) (4)
Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine. (2019) (4)
Intracellularly Truncated Human α2B-Adrenoceptors: Stable and Functional GPCRs for Structural Studies (2005) (4)
Effects of remifentanil on pharyngeal swallowing and esophageal motility - no impact of different bolus volumes, and partial antagonism by methylnaltrexone. (2021) (4)
Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration (2020) (4)
a2-Adrenoceptor density in forebrain areas of Zucker rats: no effect of genetic obesity or antiglucocorticoid treatment (1992) (4)
Diazepam and atropine as premedicants: no discrimination by monoamine metabolite and catecholamine measurements in cerebrospinal fluid and plasma (1992) (4)
618 - AMG 714 (Anti-IL-15 MAB) Ameliorates the Effects of Gluten Consumption in Celiac Disease: A Phase 2A, Randomized, Double-Blind, Placebo-Controlled Study Evaluating AMG 714 in Adult Patients with Celiac Disease Exposed to a High-Dose Gluten Challenge (2018) (4)
Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain (2020) (4)
Morphine-Induced Cardiovascular Stimulation: The Effects of Two Doses on Healthy Subjects (2000) (4)
Evaluation of [11C]ORM-13070 as a PET tracer for α2C-adrenoceptors in the human brain (2014) (4)
Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells. (1994) (4)
Quantitative determination of α(2B)-adrenoceptor-evoked myosin light chain phosphorylation in vascular smooth muscle cells. (2014) (4)
PET in drug discovery and development: an introduction. (1999) (4)
Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine (2019) (4)
Monoamine metabolite and catecholamine measurements in cerebrospinal fluid in determining the quality of the pre-operative night's sleep. (1993) (3)
Treating gambling disorder with as needed administration of intranasal naloxone: a pilot study to evaluate acceptability, feasibility and outcomes (2019) (3)
A series of 6-(omega-methanesulfonylthioalkoxy)-2-N-methyl- 1,2,3, 4-tetrahydroisoquinolines: cysteine-reactive molecular yardsticks for probing alpha2-adrenergic receptors. (1998) (3)
Speech is Special. The Stress Effects of Speech, Noise, and Silence during Tasks Requiring Concentration. (2020) (3)
The hypotensive action of 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A) in spontaneously hypertensive rats. (1985) (3)
Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α2-adrenoceptor antagonist vatinoxan hydrochloride. (2019) (3)
Continuous positive airway pressure with and without high-frequency ventilation: hemodynamics, oxygenation, and endocrine response. (1988) (3)
Nitrogen Balance after the Administration of a Prolonged-Release Protein Substitute for Phenylketonuria as a Single Dose in Healthy Volunteers (2021) (3)
Apomorphine does not affect the basal insulin secretion in humans. (1985) (3)
Plasma levels of atrial natriuretic factor and catecholamines in endotoxin shock in dogs. (1989) (3)
The effect of clorgyline on noradrenergic function (2004) (3)
Hormonal, haemodynamic, and subjective effects of intravenously infused indomethacin: no change in the physiological response to hypertonic saline challenge. (1989) (3)
The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition (2004) (3)
Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain (2010) (2)
Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects (1987) (2)
Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti‐inflammatory drug: A randomized, placebo‐controlled, double‐blind clinical trial (2021) (2)
Subcutaneously administered dexmedetomidine is efficiently absorbed and is associated with attenuated cardiovascular effects in healthy volunteers (2018) (2)
Adrenergic bronchodilators and potassium. (1987) (2)
IC-P2-133: Reproducibility of automated ROI analysis of PET amyloid ligand [11C]PIB uptake (2008) (2)
Monoamine metabolite levels in rat CSF: kinetic studies. (1987) (2)
DEXMETETOMIDINE PREMEDICATION BEFORE REGIONAL INTRAVENOUS ANESTHESIA IN MINOR OUTPATIENT HAND SURGERY (1992) (2)
Clinical trial site identification practices and the use of electronic health records in feasibility evaluations: An interview study in the Nordic countries (2021) (2)
A deletion polymorphism of the alpha2B-adrenergic receptor gene is not associated with late complications in Type 1 diabetic patients. (2005) (2)
Neuroendocrine aspects in monitoring of dopaminergic drugs in man. (1985) (2)
Different plasma concentrations of dex- and levomedetomidine after intravenous bolus administration of racemic medetomidine in dogs (2014) (2)
The role of active transport in the transcellular movement of the peripheral α2-adrenoceptor antagonist, MK-467: An in vitro pilot study. (2017) (2)
Biochemical and clinical assessment of histamine blockade. (1996) (1)
Neuroendocrine response to laparoscopic cholecystectomy with abdominal wall lift or conventional method: 1. (1996) (1)
Pharmacodynamic and pharmacokinetic profile of SM‐1, a triple‐drug combination to increase total sleep time (2019) (1)
Assessing an Electronic Health Record research platform for identification of clinical trial participants (2020) (1)
CARDIOVASCULAR AND SYMPATHOLYTIC EFFECTS OF INTRAMUSCULAR DEXMEDETOMIDINE IN MAN (1989) (1)
Increased Energy Expenditure, White Adipose Tissue Browning, And Resistance to Central Obesity And Type 2 Diabetes in Mice Lacking Alpha2‐Adrenoceptors (2016) (1)
Influence of MK-467 on the absorption of medetomidine after intramuscular administration in dogs – Preliminary results (2015) (1)
Might the observed a 2 A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations ? q (2013) (1)
Effects of intramuscular vatinoxan (MK-467), co-administered with medetomidine and butorphanol, on cardiopulmonary and anaesthetic effects of intravenous ketamine in dogs. (2020) (1)
G Protein-Coupled Receptors as Cardiovascular Drug Targets (2005) (1)
Uptake of 18F-rhPSMA-7.3 in Positron Emission Tomography Imaging of Prostate Cancer: A Phase 1 Proof-of-Concept Study. (2021) (1)
A randomized pharmacokinetic-pharmacodynamic evaluation of the potential biosimilar interferon beta-1a product, CinnoVex® (2021) (1)
Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs (2018) (1)
Candida antarctica Lipase A-Based Enantiorecognition of a Highly Strained 4-Dibenzocyclooctynol (DIBO) Used for PET Imaging (2020) (1)
Genetic Variations in the . 2A-adrenoreceptor Are Associated with Blood (2017) (1)
A two-site immunometric assay for the detection of the expression level of α2(C2)-adrenergic receptor produced in Escherichia coli (2000) (1)
Bioavailability of dexmedetomidine after intranasal administration in healthy subjects: 9AP5–4 (2010) (1)
Assessment of alpha2-adrenoceptor antagonist potency with GTPase assay. (1997) (1)
Pharmacokinetics of deramciclane and N-desmethylderamciclane after single and repeated oral doses in healthy volunteers. (2004) (1)
Comparison of simultaneous measurement of mouse locomotor activity by radiotelemetry and photobeam methods. (2015) (1)
Hydroxychloroquine in the treatment of adult patients with Covid-19 infection in a primary care setting (LIBERTY): A structured summary of a study protocol for a randomised controlled trial (2021) (1)
Results of a Phase I clinical trial of intrathecal fadolmidine, a novel alpha2-adrenoceptor agonist with potential as a spinal analgesic: A-506 (2006) (0)
[Receptors and mediators in nerve cells]. (1990) (0)
Rifampicin markedly decreases the exposure to oral and intravenous tramadol (2012) (0)
REET REINART-OKUGBENI Assay systems for characterisation of subtype-selective binding and functional activity of ligands on dopamine receptors (2012) (0)
The polymorphic deleted-form of the human a 2 B-adrenergic receptor and its wild-type counterpart display post-receptor signaling pathway differences in LLC-PK 1 cells (2016) (0)
adrenoceptors on renal sensory nerves 2 α activation of efferent and afferent renal nerve activity by altering Dietary sodium modulates the interaction between (2011) (0)
Cloning and expression of a fish x2-adrenoceptor (2007) (0)
[Drug development--from receptor research to therapy]. (1998) (0)
T164 DOES AN ALPHA‐2‐ADRENOCEPTOR ANTAGONIST AUGMENT THE PAIN‐SUPPRESSIVE EFFECT OF A PARTIAL OPIOID AGONIST IN A RAT MODEL OF PERIPHERAL NEUROPATHY? (2011) (0)
Comparison of the effects of metoclopramide on sympathetic and muscarinic responses after pretreatment with atropine and pirenzepine. (1988) (0)
P714Quantitative determination of alpha2-adrenoceptor-evoked myosin light chain phosphorylation in vascular smooth muscle cells (2014) (0)
Application of the ligand 11 C-ORM-13070 to examine receptor by the selective -adrenoceptor antagonist validation of (2020) (0)
4-42-03 COMT inhibition by entacapone: Interactions, haemodynamics and catecholamine metabolism (1997) (0)
THE EFFECT OF β‐BLOCKADE ON PLASMA POTASSIUM AND MAGNESIUM HOMEOSTASIS DURING EXERCISE (1996) (0)
The effect of P-glycoprotein on the transport of the acepromazine and dexmedetomidine, and the peripheral alpha-2-antagonist, MK-467, in vitro (2014) (0)
Medicine used in surgery operation containing 4-substituted imidazole derivative as an active ingredient (1989) (0)
Characterization of [3H]atipamezole as a radioligand for alpha 2-adrenoceptors. (1992) (0)
ON THE PHARMACOKINETIC AND PHARMACODYNAMIC PROFILE OF THE NOVEL ANTIDEPRESSIVE, NOMIFENSINE (1986) (0)
Peripheral alpha 2-adrenoceptor antagonism affects the absorption of intramuscularly co-administered drugs (2018) (0)
Oral Premedication with Clinidine: Effects on Stress Responses During General Anesthesia (1988) (0)
Evidence that the multiflorine‐derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at α2‐adrenoceptors in mice (2019) (0)
Suomen lääketutkimuksen tohtoriohjelman (FinPharma Doctoral Program, FPDP) 6. vuositapaaminen Turun yliopistossa 16.-17.8.2012 = : FinPharma Doctoral Program (FPDP) : 6th Joint meeting at the University of Turku, August 16-17, 2012, Turku, Finland (2012) (0)
1042 Determinants of coronary flow velocity reserve in healthy young men (2005) (0)
Alpha2c-Adrenoceptor Overexpressing Mice as a Model to Study Cognitive Functions of Alpha2-Adrenoceptors (1997) (0)
The effects of dexmedetomidine, a peripherally acting α2-antagonist (MK-467) and glibenclamide on blood glucose and lactate concentrations in dogs – Preliminary results (2015) (0)
Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS – a PET study in human subjects (2015) (0)
Alpha-2B adrenoceptor polymorphism: effects on peripheral vasoconstriction in healthy volunteers: A-197 (2005) (0)
ENETS Newsletter Summer/Fall 2012 (2012) (0)
Reply to "Letter to the editor: 'Deconstructing the dogma of sympathetic restraint and its role in the cardiovascular response to exercise'". (2014) (0)
Genetic Polymorphisms: An Insertion/Deletion Polymorphism of the a2B-Adrenoceptor Gene as a Risk Factor for Acute Coronary Events (2007) (0)
Pharmacokinetics of fenclofenac in children with juvenile rheumatoid arthritis (2004) (0)
The effect of skin incision followed by alfentanil on catecholamine levels and on the T-wave amplitude of ECG during isoflurance anaesthesia (1995) (0)
Decreased CSF Norepinephrine and Monoamine Metabolites in Schizophrenic Patients with Brain Atrophy as Shown with CT Scans (1985) (0)
Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility—A double‐blind randomized cross‐over study in healthy volunteers (2022) (0)
Cardiac Arrest and Pulmonary Edema Variation in the Alpha 2 B-Adrenoceptor Gene as a Risk Factor for Prehospital Fatal Myocardial Infarction and Sudden Cardiac Death (2016) (0)
CYP2A6 genetic variation and dexmedetomidine disposition (2012) (0)
Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol (2015) (0)
A Voxel-Based Morphometry Study of Brain Volumetry and Diffusivity in Als Patients With Mild Disability (2007) (0)
[Acute maprotiline poisoning]. (1981) (0)
Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects (2015) (0)
Shock III (2011) (0)
Application of cross-species PET imaging to assess neurotransmitter release in brain (2015) (0)
Acidic amine buffers in electrochemical detection liquid chromatography. (2009) (0)
Acute coronary event risk-increasing polymorphisms of α2B adrenergic receptor and serum paraoxonase genes. demonstration of a gene-gene instruction (2000) (0)
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction (2012) (0)
P2-073: Reproducibility of automated ROI analysis of PET amyloid ligand [11C]PIB uptake (2008) (0)
0006 The Pharmacokinetics and Pharmacodynamics of SM-1 (2018) (0)
Anne Vuorenpää: CELLULAR REGULATION OF THE NOREPINEPHRINE TRANSPORTER (2018) (0)
Imaging of α2C-adrenoceptors in the living brain: a method to monitor noradrenaline release? (2015) (0)

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