Mikio Furuse
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Researcher ORCID ID = 0000-0003-2847-8156
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Computer Science
Mikio Furuse's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Mikio Furuse's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Occludin: a novel integral membrane protein localizing at tight junctions (1993) (2490)
- Multifunctional strands in tight junctions (2001) (2350)
- Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin (1998) (2026)
- Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice (2003) (1563)
- Claudin-based tight junctions are crucial for the mammalian epidermal barrier (2002) (1393)
- Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. (1999) (1134)
- Complex phenotype of mice lacking occludin, a component of tight junction strands. (2000) (1123)
- Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins (1999) (1111)
- Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions (1994) (959)
- A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts (1998) (927)
- Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells (1999) (842)
- ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation (2006) (738)
- Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands (1999) (737)
- Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells (2001) (715)
- Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. (1993) (695)
- Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells (2005) (691)
- Occludin is a functional component of the tight junction. (1996) (671)
- Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail (2003) (652)
- Occludin as a possible determinant of tight junction permeability in endothelial cells. (1997) (650)
- Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation (1997) (613)
- Occludin and claudins in tight-junction strands: leading or supporting players? (1999) (589)
- Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions (1998) (570)
- Claudins in occluding junctions of humans and flies. (2006) (517)
- Pores in the wall: claudins constitute tight junction strands containing aqueous pores. (2000) (482)
- Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis (1999) (442)
- Molecular basis of the core structure of tight junctions. (2010) (364)
- Claudin-based barrier in simple and stratified cellular sheets. (2002) (364)
- Multi-PDZ Domain Protein 1 (MUPP1) Is Concentrated at Tight Junctions through Its Possible Interaction with Claudin-1 and Junctional Adhesion Molecule* (2002) (362)
- Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues (1996) (345)
- Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. (2002) (344)
- Junctional adhesion molecule (JAM) binds to PAR-3 (2001) (314)
- Structural and signalling molecules come together at tight junctions. (1999) (310)
- Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. (2001) (305)
- Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein (2000) (285)
- Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands (1999) (280)
- Mammalian occludin in epithelial cells: its expression and subcellular distribution. (1997) (280)
- Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1* (2004) (261)
- Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules (2010) (248)
- The Structure and Function of Claudins, Cell Adhesion Molecules at Tight Junctions (2000) (240)
- Commensal microbiota modulate murine behaviors in a strictly contamination‐free environment confirmed by culture‐based methods (2013) (218)
- A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells (2004) (217)
- LSR defines cell corners for tricellular tight junction formation in epithelial cells (2011) (207)
- Dynamic behavior of paired claudin strands within apposing plasma membranes (2003) (206)
- Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. (1996) (202)
- Loss of occludin affects tricellular localization of tricellulin. (2008) (191)
- Megaintestine in claudin-15-deficient mice. (2008) (189)
- Ca2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions (1999) (173)
- Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization (2007) (172)
- Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential (2004) (167)
- Differential behavior of E‐cadherin and occludin in their colocalization with ZO‐1 during the establishment of epithelial cell polarity (1999) (163)
- Analysis of the ‘angulin’ proteins LSR, ILDR1 and ILDR2 – tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis (2013) (161)
- Expression patterns of claudins, tight junction adhesion molecules, in the inner ear (2004) (154)
- Tight Junction Structure and Function Revisited. (2020) (154)
- Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. (1998) (139)
- Expression of occludin, tight-junction-associated protein, in human digestive tract. (1997) (136)
- Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells (1992) (136)
- Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. (2013) (129)
- Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. (2007) (128)
- C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (1992) (125)
- Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin. (1998) (124)
- B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis. (1998) (109)
- Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice. (2013) (108)
- Overcoming barriers in the study of tight junction functions: from occludin to claudin (1998) (105)
- Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis. (2012) (104)
- The Drosophila Claudin Kune-kune Is Required for Septate Junction Organization and Tracheal Tube Size Control (2010) (104)
- Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity (2019) (100)
- The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells (2009) (98)
- Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties (2007) (97)
- Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins (2009) (88)
- Expression and distribution of ZO‐3, a tight junction MAGUK protein, in mouse tissues (2003) (80)
- Strong induction of ICAM‐1 in human T cells transformed by human T‐cell‐leukemia virus type 1 and depression of ICAM‐1 or LFA‐1 in adult T‐cell‐leukemia‐derived cell lines (1992) (78)
- Tight junctions in Schwann cells of peripheral myelinated axons (2005) (76)
- Knockout animals and natural mutations as experimental and diagnostic tool for studying tight junction functions in vivo. (2009) (74)
- Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum. (2015) (71)
- [Molecular organization of tricellular tight junctions]. (2014) (71)
- Claudins in Caenorhabditis elegans Their Distribution and Barrier Function in the Epithelium (2003) (69)
- Molecular organization and function of invertebrate occluding junctions. (2014) (69)
- Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42 (2014) (68)
- Molecular dissection of tight junctions. (1996) (68)
- CD44 regulates tight-junction assembly and barrier function. (2011) (66)
- Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape (2016) (65)
- Molecular organization of tricellular tight junctions (2014) (65)
- Expression of claudin‐5 in dermal vascular endothelia (2003) (63)
- Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland (2004) (62)
- ZO-1 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Involvement of ZO-1 in the Regulation of Cytoskeleton and Cell Shape (2014) (61)
- Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region (2003) (61)
- JACOP, a Novel Plaque Protein Localizing at the Apical Junctional Complex with Sequence Similarity to Cingulin* (2004) (61)
- Localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo. (2014) (60)
- Claudin-3-deficient C57BL/6J mice display intact brain barriers (2019) (59)
- Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. (2002) (57)
- A novel protein complex, Mesh–Ssk, is required for septate junction formation in the Drosophila midgut (2012) (56)
- Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells (2014) (54)
- Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase* (2010) (43)
- Tight junctions in epidermis: from barrier to keratinization. (2011) (39)
- Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila (2012) (39)
- Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease. (1999) (39)
- Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function (2021) (34)
- Promotion of lymphatic integrity by angiopoietin-1/Tie2 signaling during inflammation. (2012) (34)
- Lipolysis‐stimulated lipoprotein receptor: a novel membrane protein of tricellular tight junctions (2012) (34)
- A tetraspanin regulates septate junction formation in Drosophila midgut (2016) (33)
- Claudin-2 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Claudin-2 Independently Determines the Leaky Property of Tight Junctions in MDCK Cells (2015) (31)
- Claudin-2 Regulates Colorectal Inflammation via Myosin Light Chain Kinase-Dependent Signaling (2013) (31)
- Molecular architecture of tight junctions: occludin and ZO-1. (1997) (31)
- Deficiency of Angulin-2/ILDR1, a Tricellular Tight Junction-Associated Membrane Protein, Causes Deafness with Cochlear Hair Cell Degeneration in Mice (2015) (30)
- JNK1/2‐dependent phosphorylation of angulin‐1/LSR is required for the exclusive localization of angulin‐1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet (2014) (30)
- A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. (2011) (30)
- Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. (1997) (28)
- Claudins and renal salt transport (2012) (26)
- Nuclear localization and transforming activity of human papillomavirus type 16 E7-beta-galactosidase fusion protein: characterization of the nuclear localization sequence. (1994) (26)
- Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology (2017) (24)
- Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes. (2011) (24)
- Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency (2011) (23)
- Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease–Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo (2017) (23)
- Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. (2008) (22)
- Analysis of the ‘angulin’ proteins LSR, ILDR1 and ILDR2 – tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis (2013) (22)
- The Role of Claudin‐Based Tight Junctions in Morphogenesis (2009) (22)
- Physiological functions of junctional adhesion molecules (JAMs) in tight junctions. (2020) (21)
- Downsloping High-Frequency Hearing Loss Due to Inner Ear Tricellular Tight Junction Disruption by a Novel ILDR1 Mutation in the Ig-Like Domain (2015) (20)
- abLIM3 is a novel component of adherens junctions with actin-binding activity. (2010) (19)
- Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila (2019) (19)
- Endothelial Claudin (1999) (17)
- Claudin‐5 haploinsufficiency exacerbates UVB‐induced oedema formation by inducing lymphatic vessel leakage (2012) (15)
- Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain. (2003) (14)
- Angulin-1 seals tricellular contacts independently of tricellulin and claudins (2020) (13)
- Effects of Osmolality on Paracellular Transport in MDCK II Cells (2016) (13)
- Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export (2020) (12)
- 1H, 13C, and 15N resonance assignment of the first PDZ domain of mouse ZO-1 (2011) (12)
- Introduction to the Blood–Brain Barrier: Molecular dissection of tight junctions: occludin and ZO-1 (1998) (11)
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport and paracellular permeability in the Drosophila Malpighian tubule. (2020) (11)
- [Identification of two distinct types of four-transmembrane domain proteins, occludin and claudins: towards new physiology in paracellular pathway]. (2000) (10)
- Chapter 1 – Introduction ☆: Claudins, Tight Junctions, and the Paracellular Barrier (2010) (9)
- Vangl2 interaction plays a role in the proteasomal degradation of Prickle2 (2019) (9)
- The Septate Junction Protein Tetraspanin 2A is critical to the Structure and Function of Malpighian tubules in Drosophila melanogaster. (2020) (9)
- Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells (2017) (7)
- Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. (1998) (7)
- JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells (2022) (7)
- Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland (2021) (7)
- Recent advances in understanding tight junctions (2021) (7)
- Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine (2020) (7)
- Overexpression of Interferon α/β Receptor β Chain in Fetal Down Syndrome Brain (2004) (7)
- A "Tric" to tighten cell-cell junctions in the cochlea for hearing. (2013) (6)
- Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia (2015) (6)
- Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers (2017) (6)
- Tight Junction Structure and Function Revisited: (Trends in Cell Biology 30:10, p:XXX-YYY, 2020). (2020) (6)
- A 155-kDa undercoat-constitutive protein of cell-to-cell adherens junctions. (1997) (5)
- Generation of transgenic medaka expressing claudin7-EGFP for imaging of tight junctions in living medaka embryos (2009) (5)
- Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes (2022) (5)
- Subcellular distribution of tight junction-associated proteins, occludin, ZO-1 and ZO-2, in rodent skin and its developmental changes (1998) (5)
- Nanoscale segregation of channel and barrier claudins enables paracellular ion flux (2022) (5)
- The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut (2021) (4)
- EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. (2023) (3)
- Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells (1997) (3)
- The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts (2020) (3)
- Induction of strong homotypic adhesion in human T cell lines positive with human T-cell leukemia virus type 1 by monoclonal antibodies to MHC class I and beta 2-microglobulin. (1992) (3)
- Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers (2019) (3)
- Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver (2021) (3)
- Endoscopic appearance of primary appendiceal lymphoma. (1998) (3)
- A tetraspanin regulates septate junction formation in Drosophila midgut (2016) (3)
- In vivo imaging of tight junctions using claudin-EGFP transgenic medaka. (2011) (2)
- Factor V , tissue factor pathway inhibitor , and east Texas bleeding disorder (2018) (2)
- The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts. (2020) (2)
- Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches (2018) (2)
- Tight junction formation by a claudin mutant lacking the COOH‐terminal PDZ domain‐binding motif (2022) (2)
- [Molecular mechanism behind the barrier function of tight junctions]. (2006) (2)
- MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. (1998) (2)
- The blood- brain barrier and barrier function in vivo: the role of tight junctions (2013) (1)
- Pores in the Wall (2000) (1)
- Endoscopic demonstration of malignant duodenocolic fistula: two case reports. (1996) (1)
- Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine (2020) (1)
- ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions (2022) (1)
- Reciprocal regulation between cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis (2022) (0)
- Homeostatic cell turnover mechanisms that maintain tight junction barrier integrity in the epidermis (2016) (0)
- Contents Vol. 4, 2003 (2004) (0)
- Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers (2017) (0)
- IS074 OCCLUDIN : A KEY ADHESION MOLECULE FOR THE BARRIER MECHANISM OF ENDOTHELIAL CELLS (1997) (0)
- Reviewers (2007) (0)
- Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells. (2022) (0)
- Sequence Similarity to Cingulin at the Apical Junctional Complex with JACOP, a Novel Plaque Protein Localizing Developmental Biology: Molecular Basis of Cell and (2014) (0)
- Abstracts of the Fifth Joint Meeting of the Society for Skin Structure Research and the Society for Cutaneous Ultrastructure Research. May 17-19, 2008. Otsu, Japan. (2008) (0)
- 2P010 X-ray Crystallography of PDZ domain from LNX1, an E3 ubiquitin ligase regulating intercellular adhesion machinery(The 48th Annual Meeting of the Biophysical Society of Japan) (2010) (0)
- Third International Symposium on Normal and Abnormal Development of the Human Fetal Brain (2004) (0)
- Optimal liver metabolism and proliferation require the tight junction protein claudin-3 (2020) (0)
- Abstract 11570: Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo (2015) (0)
- JAM-A interacts in cis with α3β1 integrin through CD151 to regulate collective cell migration of polarized epithelial cells (2021) (0)
- Claudin-3-deficient C57BL/6J mice display intact brain barriers (2019) (0)
- Shoichiro Tsukita 1953–2005 (2006) (0)
- 344 Cell shape determines the regulatory mechanisms for maintaining tight junction barrier homeostasis in epidermal turnover (2016) (0)
- Claudins: Structural and Functional Molecular Constituents of Tight Junction Barrier. (2000) (0)
- Identification of the genes encoding candidate septate junction components expressed during early development of the sea urchin, Strongylocentrotus purpuratus, and evidence of a role for Mesh in the formation of the gut barrier. (2022) (0)
- Identification and Characterization of Occludin : A Novel Adhesion Molecule of Tight Junctions (1995) (0)
- Subject Index Vol. 4, 2003 (2004) (0)
- Author response: Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape (2016) (0)
- Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein (2013) (0)
- 1P-170 Tight junction-like structures in L cells expressing claudin-3 protein observed by quick-freeze-replica and HAADF-STEM(Cell biology, The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1 (2011) (0)
- Vangl2 interaction plays a role in the proteasomal degradation of Prickle2 (2019) (0)
- ORIGINAL RESEARCH Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver Q1 Claudin-3 knockout (2021) (0)
- Short Communication Expression ofOccludin, Tight-Junction- Associated Protein, inHumanDigestive Tract (1997) (0)
- A novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut (2020) (0)
- Polymorphism of the heat-shock protein gene HSP70-2 in ulcerative colitis (2000) (0)
- Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers (2019) (0)
- 1P-238 Search for compounds that modulate tight-junction activity : structural biology and computational approaches(Bioinformatics:Structural genomics, The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- Mechanism of interdigitation formation at apical boundary of MDCK cell (2023) (0)
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