Milton Schlesinger
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American molecular biologist
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Milton Schlesingerbiology Degrees
Biology
#6733
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#9513
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Molecular Biology
#947
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#970
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Biochemistry
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#1167
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Biology
Milton Schlesinger's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Milton Schlesinger Influential?
(Suggest an Edit or Addition)According to Wikipedia, Milton Schlesinger was a professor of molecular microbiology at the Washington University School of Medicine, known for his role in the study of heat shock proteins. Academic career Schlesinger attended Yale University as an undergraduate and received his bachelor's degree in physics in 1951. He then earned his master's degree in biophysics in 1953 from the University of Rochester and his Ph.D. in biochemistry in 1959 from the University of Michigan. He spent two years as a postdoctoral fellow at the Istituto Superiore di Sanità in Rome, Italy, and three years as a research associate at the Massachusetts Institute of Technology before joining the faculty at the Washington University School of Medicine in St. Louis, Missouri in 1967. He would remain there for the rest of his scientific career, reaching the rank of full professor in 1972 and serving two stints as the acting chair of the microbiology department. He took visiting positions and sabbaticals at the Imperial Cancer Research Fund Laboratories and at Harvard University. Schlesinger retired and assumed professor emeritus status in 1999.
Milton Schlesinger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Heat shock, from bacteria to man (1982) (952)
- Heat shock proteins. (1990) (853)
- Uncoating ATPase is a member of the 70 kilodalton family of stress proteins (1986) (561)
- The Heat Shock Respons (1985) (489)
- The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts (1978) (457)
- Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. (1985) (398)
- Heat shock proteins: the search for functions (1986) (386)
- Ubiquitin is a heat shock protein in chicken embryo fibroblasts (1985) (366)
- The Togaviridae and Flaviviridae (1986) (286)
- Antibodies to two major chicken heat shock proteins cross-react with similar proteins in widely divergent species (1982) (272)
- Fatty acid binding to vesicular stomatitis virus glycoprotein: a new type of post-translational modification of the viral glycoprotein (1979) (265)
- Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor. (1987) (217)
- The dynamic state of heat shock proteins in chicken embryo fibroblasts (1986) (209)
- Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia (1990) (205)
- Evidence for covalent attachment of fatty acids to Sindbis virus glycoproteins. (1979) (184)
- Vesicular stomatitis virus and sindbis virus glycoprotein transport to the cell surface is inhibited by ionophores. (1980) (165)
- Relation of fatty acid attachment to the translation and maturation of vesicular stomatitis and Sindbis virus membrane glycoproteins. (1980) (164)
- The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells (1986) (140)
- Identification of a second glycoprotein in Sindbis virus. (1972) (138)
- Amino acid sequence of Escherichia coli alkaline phosphatase. (1981) (136)
- The reversible dissociation of the alkaline phosphatase of Escherichia coli. I. Formation and reactivation of subunits. (1965) (135)
- The response of cells to heat shock (1982) (134)
- Evidence for an autoprotease activity of sindbis virus capsid protein. (1978) (131)
- Hybrid protein formation of E. coli alkaline phosphatase leading to in vitro complementation. (1963) (129)
- Formation of Sindbis Virus Proteins: Identification of a Precursor for One of the Envelope Proteins (1972) (128)
- Fatty acid acylation of proteins in cultured cells. (1980) (123)
- Evidence that Sindbis virus NSP2 is an autoprotease which processes the virus nonstructural polyprotein. (1989) (119)
- The Sindbis virus 6K protein can be detected in virions and is acylated with fatty acids. (1990) (114)
- Site-directed mutations in Sindbis virus E2 glycoprotein's cytoplasmic domain and the 6K protein lead to similar defects in virus assembly and budding. (1991) (107)
- Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding (1993) (107)
- How the Cell Copes with Stress and the Function of Heat Shock Proteins (1994) (103)
- Cerulenin blocks fatty acid acylation of glycoproteins and inhibits vesicular stomatitis and Sindbis virus particle formation. (1982) (99)
- Release of fatty acids from virus glycoproteins by hydroxylamine. (1984) (98)
- Ultrastructural and biochemical analysis of the stress granule in chicken embryo fibroblasts (1988) (98)
- Large-Molecular-Weight Precursors of Sindbis Virus Proteins (1973) (98)
- Heat-shock proteins and development. (1987) (97)
- Initiation sites for translation of sindbis virus 42S and 26S messenger RNAs (1975) (94)
- Ubiquitin in stressed chicken embryo fibroblasts. (1988) (91)
- Site-directed mutations in the Sindbis virus 6K protein reveal sites for fatty acylation and the underacylated protein affects virus release and virion structure. (1990) (88)
- Fluorotyrosine alkaline phosphatase from Escherichia coli: preparation, properties, and fluorine-19 nuclear magnetic resonance spectrum. (1974) (87)
- Scanning fluorescence correlation spectroscopy. II. Application to virus glycoprotein aggregation. (1986) (86)
- The 6-kilodalton membrane protein of Semliki Forest virus is involved in the budding process (1995) (85)
- Fatty acid acylation of eucaryotic cell membrane proteins (1982) (84)
- Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells. (1989) (66)
- Formation and Assembly of Alphavirus Glycoproteins (1986) (66)
- Defective virus particles from Sindbis virus. (1972) (65)
- Defects in RNA+ temperature-sensitive mutants of Sindbis virus and evidence for a complex of PE2-E1 viral glycoproteins. (1976) (64)
- The phosphate content of Escherichia coli alkaline phosphatase and its effect on stopped flow kinetic studies. (1973) (62)
- Concomitant changes in mitochondria and intermediate filaments during heat shock and recovery of chicken embryo fibroblasts (1993) (61)
- Pleiotropic Effects of Mutations Involved in the Regulation of Escherichia coli K-12 Alkaline Phosphatase (1974) (57)
- The formation of vesicular stomatitis virus (San Juan strain) becomes temperature-sensitive when glucose residues are retained on the oligosaccharides of the glycoprotein. (1984) (55)
- The reversible dissociation of the alkaline phosphatase of Escherichia coli. II. Properties of the subunit. (1965) (55)
- 13 – Translation and Processing of Alphavirus Proteins (1980) (55)
- Alterations in the structure and function of Escherichia coli alkaline phosphatase due to Zn2+ binding. (1969) (54)
- Localization of Polyribosomes Containing Alkaline Phosphatase Nascent Polypeptides on Membranes of Escherichia coli (1974) (53)
- Formation of Sindbis virus capsid protein in mammalian cell-free extracts programmed with viral messenger RNA. (1974) (53)
- The effects of inhibitors of glucosidase I on the formation of Sindbis virus. (1985) (52)
- Conformational states of the subunit of Escherichia coli alkaline phosphatase. (1967) (50)
- Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease. (1989) (49)
- Hydrolysis of nucleoside diand triphosphates by crystalline preparations of yeast inorganic pyrophosphatase. (1960) (47)
- Stress Proteins: Induction and Function (1991) (47)
- MULTIPLE MOLECULAR FORMS OF THE ALKALINE PHOSPHATASE OF ESCHERICHIA COLI * (1968) (46)
- Isolation and characterization of hybrid cell lines producing monoclonal antibodies directed against the structural proteins of Sindbis virus. (1980) (45)
- The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. IV. Substitution of canavanine for arginine. (1969) (44)
- Secretion of Alkaline Phosphatase Subunits by Spheroplasts of Escherichia coli (1968) (43)
- Formation of a defective alkaline phosphatase subunit by a mutant of Escherichia coli. (1967) (42)
- Properties of monoclonal antibodies directed against the glycoproteins of Sindbis virus. (1982) (41)
- Amino acid sequence of Escherichia coli alkaline phosphatase. Amino- and carboxyl-terminal sequences and variations between two isozymes. (1973) (41)
- Effects of Different RNAs and Components of the Cell-Free System on In Vitro Synthesis of Sindbis Viral Proteins (1974) (40)
- Expression and Localization of Escherichia coli Alkaline Phosphatase Synthesized in Salmonella typhimurium Cytoplasm (1968) (39)
- Demonstration that the 90-kilodalton heat shock protein is bound to the glucocorticoid receptor in its 9S nondeoxynucleic acid binding form. (1987) (38)
- Fluorescence photobleaching recovery measurements reveal differences in envelopment of sindbis and vesicular stomatitis viruses (1981) (37)
- Submaxillary Gland of Mouse: Properties of a Purified Protein Affecting Muscle Tissue in vitro (1967) (37)
- In vitro synthesis of heat-shock proteins by mRNAs from chicken embryo fibroblasts. (1980) (35)
- Isolation and characterization of complementation products of Escherichia coli alkaline phosphatase. (1966) (35)
- An in-frame insertion into the Sindbis virus 6K gene leads to defective proteolytic processing of the virus glycoproteins, a trans-dominant negative inhibition of normal virus formation, and interference in virus shut off of host-cell protein synthesis. (1993) (35)
- In vitro proteolytic processing of a diubiquitin and a truncated diubiquitin formed from in vitro-generated mRNAs. (1988) (34)
- Domains of Virus Glycoproteins (1987) (34)
- Alterations in Sindbis Viral Envelope Proteins by Treating BHK cells with Glucosamine (1975) (33)
- beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase. (1958) (33)
- Inhibition of Sindbis virus replication by zinc ions. (1976) (31)
- Crystallization of Sindbis virus and its nucleocapsid. (1992) (31)
- Fatty acid-acylated proteins in secretory mutants of Saccharomyces cerevisiae (1984) (31)
- A pseudo-revertant of a Sindbis virus 6K protein mutant, which corrects for aberrant particle formation, contains two new mutations that map to the ectodomain of the E2 glycoprotein. (1995) (28)
- Effects of site-directed mutations of transmembrane cysteines in sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication. (1998) (27)
- The reversible dissociation of the alkaline phosphatase of Escherichia coli. 3. Properties of antibodies directed against the subunit. (1967) (26)
- Formation of a Sindbis virus nonstructural protein and its relation of 42S mRNA function (1976) (26)
- ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION. (1964) (25)
- Hydrogen ion equilibria of conformational states of Escherichia coli alkaline phosphatase. (1968) (25)
- Infectious virus-antibody complexes of sindbis virus (1977) (25)
- Inhibition of influenza virus formation by a peptide that corresponds to sequences in the cytoplasmic domain of the hemagglutinin. (1991) (24)
- An ATP‐ and hsc70‐dependent oligomerization of nascent heat‐shock factor (HSF) polypeptide suggests that HSF itself could be a “sensor” for the cellular stress response (1993) (23)
- Formation and properties of a tetrameric form of Escherichia coli alkaline phosphatase. (1969) (22)
- FORMATION AND LOCALIZATION OF THE ALKALINE PHOSPHATASE OF ESCHERICHIA COLI * (1969) (22)
- Lipid Modifications of Proteins (1992) (22)
- Viral Proteins Formed in a Cell-Free RABBIT Reticulocyte System Programmed with RNA from a Temperature-Sensitive Mutant of Sindbis Virus (1974) (22)
- Identification of a Compound related to 6-Aminopenicillanic Acid, isolated from Culture Media of Penicillium chrysogenum (1961) (20)
- Kinetics of substrate hydrolysis by molecular variants of Escherichia coli alkaline phosphatase. (1974) (19)
- Verapamil and chlorpromazine inhibit the budding of Sindbis and vesicular stomatitis viruses from infected chicken embryo fibroblasts. (1989) (19)
- Induction of heat-shock proteins in the embryonic chicken lens. (1986) (19)
- Activation of a mutationally altered form of the Escherichia coli alkaline phosphatase by zinc. (1966) (19)
- Inhibition of Enveloped RNA Virus Formation by Peptides Corresponding to Glycoprotein Sequences (1992) (19)
- Regulated expression of Sindbis and vesicular stomatitis virus glycoproteins in Saccharomyces cerevisiae. (1986) (19)
- Formation of an infectious virus-antibody complex with Rous sarcoma virus and antibodies directed against the major virus glycoprotein (1976) (19)
- Inhibitory effects of HSP70 chaperones on nascent polypeptides (1992) (19)
- Characterization of revertants of a Sindbis virus 6K gene mutant that affects proteolytic processing and virus assembly. (1995) (19)
- A chicken repetitive DNA sequence that is highly sensitive to single-strand specific endonucleases. (1983) (18)
- Effects of Proline Analogues on the Formation of Alkaline Phosphatase in Escherichia coli (1972) (18)
- 9 – Stress Response in Avian Cells (1985) (18)
- In Vitro Formation of Enzymatically Active Hybrid Proteins from E. Coli Alkaline Phosphatase CRM's (1963) (17)
- Isolation of a Sindbis virus variant by passage on mouse plasmacytoma cells (1975) (15)
- A new, simple, rapid procedure for purification of Escherichia coli alkaline phosphatase. (1970) (13)
- Altered E2 glycoprotein of Sindbis virus and its use in complementation studies (1978) (12)
- Metabolite changes associated with heat shocked avian fibroblast mitochondria. (1997) (12)
- DIFFERENCES IN THE STRUCTURE, FUNCTION, AND FORMATION OF TWO ISOZYMES OF ESCHERICHIA COLI ALKALINE PHOSPHATASE (1975) (12)
- [63] Fatty acid acylation of eukaryotic cell proteins (1983) (11)
- Escherichia coli alkaline phosphatase. Kinetic studies with the tetrameric enzyme. (1972) (11)
- Mutationally altered rate constants in the mechanism of alkaline phosphatase. (1974) (10)
- Expression of genes encoding vesicular stomatitis and Sindbis virus glycoproteins in yeast leads to formation of disulfide-linked oligomers. (1986) (10)
- Complementation at the molecular level of enzyme interaction. (1965) (9)
- Expression and glycosylation of the respiratory syncytial virus G protein in Saccharomyces cerevisiae. (1987) (9)
- The Togaviridiae and Flaviviridae. Plenum Press, New York, London (1986), 1 vol. (17 x 25,5 cm), 453 + xv pages (1986) (9)
- Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver. (1961) (9)
- The Ubiquitin System and the Heat Shock Response (1990) (9)
- The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. I. Substitution of triazolealanine for histidine. (1967) (9)
- Reaction of the protease inhibitor p-nitrophenyl-p'-guanidinobenzoate with Sindbis virus. (1977) (8)
- Hybrid Protein Formation of E. coli Alkaline Phosphatase Leading to in vitro Complementation (1989) (8)
- A mutationally altered alkaline phosphatase from Escherichia coli. II. Structural and catalytic properties of the activated enzyme. (1972) (8)
- In vitro Inhibition of Nascent Polypeptide Formation by HSP70 Proteins (1991) (7)
- Mutations in the Sindbis virus capsid gene can partially suppress mutations in the cytoplasmic domain of the virus E2 glycoprotein spike. (1998) (7)
- Heat shock in vertebrate cells. (1996) (6)
- Fatty Acid acylation of membrane proteins. (1982) (6)
- The protease inhibitor p-nitrophenyl-p' -guanidinobenzoate inactivates sindbis and other enveloped viruses. (1977) (6)
- Antiviral Activities of Peptides with Sequences Related to the Cytoplasmic Domain of the Respiratory Syncytial Virus Glycoproteins (1995) (5)
- Partial purification and substrate specificity of a ubiquitin hydrolase from Saccharomyces cerevisiae. (1991) (5)
- The cellular response to stress. (1989) (5)
- Characterization of a Sindbis virus variant with altered host range (2005) (5)
- The Replication of Togaviridae and Flaviviridae at the Molecular Level (1987) (4)
- A mutationally altered alkaline phosphatase from Escherichia coli. I. Formation of an active enzyme in vitro and phenotypic suppression in vivo. (1972) (4)
- Induction of the stress response in alpha 1-antitrypsin deficiency. (1988) (3)
- SINDBIS AND SEMLIKI FOREST VIRUSES (TOGAVIRIDAE) (1999) (3)
- Variants of Escherichia coli Alkaline Phosphatase: An Example of the Role of Genetics in a Study of Protein Structure aad Function (1974) (3)
- The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. 3. Substitution of 2-methylhistidine for histidine. (1969) (2)
- Hybrid tetramers of alkaline phosphatase (1973) (2)
- Function of Sindbis virus 49S and 26S RNAs in in vitro protein synthesizing systems. A summary. (1975) (1)
- Virus cover-up Assembly of enveloped RNA viruses. Edited by M. Dubois-Dalcq, K. V. Holmes, and B. Rentier. New York: Springer-Verlag. (1984). 235 pp. $49.50 (1985) (1)
- IN VITRO COMPLEMENTATION AND THE SUBUNIT STRUCTURE OF E. COLI ALKALINE PHOSPHATASE. (1964) (1)
- Peptides as inhibitors of enveloped virus formation (1994) (1)
- Viral Proteins Formedina Cell-Free RABBIT Reticulocyte SystemProgrammed withRNA froma Temperature-Sensitive MutantofSindbis Virus (1974) (1)
- The Enzymic Synthesis of Branched‐Chain Acids (2009) (0)
- Regulated expression ofSindbis andvesicular stomatitis virus glycoproteins inSaccharomyces cerevisiae (1986) (0)
- Effect of the amino acid analogue canavanine on synthesis of actin and tubulin in tissue culture cells (1977) (0)
- Heat Stress in Avian Cells (1997) (0)
- 5 Genetic Probes of Enzyme Structure (1970) (0)
- Formation of RNA and protein in cells infected with standard and defective Sindbis virus (2005) (0)
- Characterization of a mutationally altered glyco protein of sindbis virus and its use in biochemical complementation studies (1976) (0)
- Enveloped Viruses as Models for Membrane Assembly (1992) (0)
- Letter: Hybrid tetramers of alkaline phosphatase. (1973) (0)
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