Mirit I. Aladjem
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Israeli-American biologist
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Mirit I. Aladjembiology Degrees
Biology
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Genetics
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#1907
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Molecular Biology
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#2684
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Biology
Mirit I. Aladjem's Degrees
- Bachelors Biology Tel Aviv University
- Masters Molecular Biology Stanford University
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Why Is Mirit I. Aladjem Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mirit I. Aladjem is an Israeli-American biologist researching cellular signaling pathways that regulate DNA synthesis. She is a senior investigator in the National Cancer Institute's developmental therapeutics branch and head of the DNA replication group.
Mirit I. Aladjem's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Systems Biology Graphical Notation (2009) (894)
- BioPAX – A community standard for pathway data sharing (2010) (594)
- Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes* (2003) (472)
- ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage (1998) (462)
- The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses (2007) (222)
- Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication (1995) (214)
- Genetic dissection of a mammalian replicator in the human beta-globin locus. (1998) (209)
- Replication in context: dynamic regulation of DNA replication patterns in metazoans (2007) (206)
- SLFN11 Blocks Stressed Replication Forks Independently of ATR. (2018) (155)
- Molecular interaction maps of bioregulatory networks: a general rubric for systems biology. (2005) (152)
- Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes (2011) (139)
- Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage. (2010) (138)
- Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse (2018) (134)
- Genome-wide depletion of replication initiation events in highly transcribed regions. (2011) (123)
- Corrigendum: The BioPAX community standard for pathway data sharing (2010) (114)
- Software support for SBGN maps: SBGN-ML and LibSBGN (2012) (102)
- ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin (2013) (100)
- Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. (2007) (96)
- CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines (2018) (94)
- Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors (2006) (93)
- Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors. (2017) (92)
- Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle (2013) (87)
- The replicon revisited: an old model learns new tricks in metazoan chromosomes (2004) (82)
- A chromatin structure‐based model accurately predicts DNA replication timing in human cells (2014) (77)
- SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism (2013) (68)
- Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. (2008) (67)
- Dynamic Alterations of Replication Timing in Mammalian Cells (2003) (66)
- The Human β-Globin Replication Initiation Region Consists of Two Modular Independent Replicators (2004) (63)
- DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells (2006) (63)
- DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer. (2014) (61)
- CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics (2020) (60)
- The cyclin‐dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles (2007) (59)
- Replication Initiation Patterns in the β-Globin Loci of Totipotent and Differentiated Murine Cells: Evidence for Multiple Initiation Regions (2002) (59)
- Depicting combinatorial complexity with the molecular interaction map notation (2006) (59)
- HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression (2018) (57)
- Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences (2011) (55)
- Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress. (2021) (55)
- The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage (2015) (53)
- Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks (2004) (51)
- SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures (2020) (51)
- Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. (2004) (50)
- Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. (2012) (49)
- Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization (2014) (49)
- p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine (2006) (47)
- Allele-specific analysis of DNA replication origins in mammalian cells (2015) (46)
- DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication. (2007) (45)
- Distinct epigenetic features of differentiation-regulated replication origins (2016) (44)
- Order from clutter: selective interactions at mammalian replication origins (2016) (44)
- Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization. (2014) (42)
- SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing (2014) (42)
- The BioPAX community standard for pathway data sharing (Nature Biotechnology (2010) 28, (935-942)) (2012) (41)
- The Human β-Globin Locus Control Region Can Silence as Well as Activate Gene Expression (2005) (40)
- Preventing gene silencing with human replicators (2006) (39)
- Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome. (2014) (39)
- Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome (2014) (39)
- Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. (2003) (36)
- Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy (2018) (32)
- Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization (2016) (31)
- The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin (2018) (30)
- Chromatin challenges during DNA replication: a systems representation. (2008) (30)
- Circuit diagrams for biological networks (2006) (29)
- A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells (2016) (28)
- A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells (2020) (26)
- Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability (2017) (25)
- Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases (2020) (24)
- A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method (2011) (24)
- The mammalian beta globin origin of DNA replication. (2004) (22)
- BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks (2020) (21)
- Replication origins: determinants or consequences of nuclear organization? (2016) (20)
- Erratum: The Systems Biology Graphical Notation (2009) (20)
- PathVisio-MIM: PathVisio plugin for creating and editing Molecular Interaction Maps (MIMs) (2011) (19)
- ColoWeb: a resource for analysis of colocalization of genomic features (2015) (19)
- The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma (2020) (18)
- Predicted Role of NAD Utilization in the Control of Circadian Rhythms during DNA Damage Response (2015) (17)
- Cooperative sequence modules determine replication initiation sites at the human beta-globin locus. (2006) (17)
- Prevention of Transcriptional Silencing by a Replicator-Binding Complex Consisting of SWI/SNF, MeCP1, and hnRNP C1/C2 (2011) (17)
- Replication timing and nuclear structure. (2018) (17)
- Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability. (2020) (17)
- Mapping Replication Origin Sequences in Eukaryotic Chromosomes (2014) (17)
- Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation (2014) (16)
- Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer (2020) (16)
- Predicted Functions of MdmX in Fine-Tuning the Response of p53 to DNA Damage (2010) (16)
- BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage (2021) (16)
- Dynamics of replication origin over-activation (2020) (15)
- The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation (2020) (14)
- The mechanism of carcinogen-induced DNA amplification: in vivo and in vitro studies. (1992) (13)
- Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells (1997) (12)
- The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation (2021) (12)
- Initiation of DNA replication at the human β-globin 3′ enhancer (2005) (11)
- Correction: Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle (2013) (11)
- Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability. (2018) (10)
- The chromatin backdrop of DNA replication: lessons from genetics and genome-scale analyses. (2012) (10)
- Mapping replication fork direction by leading strand analysis. (1997) (10)
- The ligand binding domain of the nicotinic acetylcholine receptor (1993) (9)
- BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1‐MCM2 signaling during pregnancy (2018) (9)
- Regulation of Replication Origins. (2017) (8)
- PathVisio-Faceted Search: an exploration tool for multi-dimensional navigation of large pathways (2013) (8)
- Cell Cycle Control: Molecular Interaction Map (2006) (8)
- Chk 2 Molecular InteractionMap and Rationale for Chk 2 Inhibitors (2006) (8)
- Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis (2009) (7)
- PathVisio-Validator: a rule-based validation plugin for graphical pathway notations (2012) (7)
- ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization (2020) (7)
- SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing (2021) (7)
- Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy. (2022) (6)
- Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells (2020) (6)
- Best Practices for Mapping Replication Origins in Eukaryotic Chromosomes (2014) (6)
- Targeted Deletion of the Chicken β-Globin Regulatory Elements Reveals a Cooperative Gene Silencing Activity* (2005) (5)
- Enhancement of copper resistance and CupI amplification in carcinogen-treated yeast cells (2004) (5)
- 2 Eukaryotic DNA Replication Origins (2006) (5)
- Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells (2021) (5)
- Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I (2022) (4)
- Switching DCAFs: Beyond substrate receptors (2021) (4)
- A new light on DNA replication from the inactive X chromosome (2014) (4)
- Human Papillomavirus Integration: Analysis by Molecular Combing and Fiber‐FISH (2018) (4)
- Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells (2021) (3)
- BEND3 safeguards pluripotency by repressing differentiation-associated genes (2022) (3)
- SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures (2020) (3)
- Integrative analysis of pharmacogenomics in major cancer cell line databases using CellMinerCDB (2018) (3)
- Rif1 choreographs DNA replication timing (2012) (3)
- Erratum: The BioPAX community standard for pathway data sharing (Nat. Biotechnol. (2010) 28 (935-942) (2010) (2)
- Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity (2021) (2)
- Replication checkpoint selectivity for late S phase cells induced by topoisomerase I cleavage complexes (2006) (2)
- Replication Stress Defines Distinct Molecular Subtypes Across Cancers (2021) (2)
- BAMscale: quantification of DNA sequencing peaks and generation of scaled coverage tracks (2019) (2)
- Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells (2011) (2)
- Faculty Opinions recommendation of H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. (2016) (1)
- 1Interactions between replication and chromatin condensation in the human beta-globin locus (2007) (1)
- Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation (2022) (1)
- Faculty Opinions recommendation of Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. (2019) (1)
- RepID-deficient cancer cells are sensitized to a drug targeting p97/VCP segregase (2021) (1)
- Establishment of Replicative Immortality in Cancer Cells (2014) (1)
- Corrigendum to “DNA-PK Is Involved in Repairing a Transient Surge of DNA Breaks Induced by Deceleration of DNA Replication” [J. Mol. Biol. 367 (2007) 665–680] (2007) (1)
- Preventing excess replication origin activation to ensure genome stability. (2021) (1)
- Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes. (2023) (1)
- Abstract 212: Sarcoma-CellMiner: An extensive resource for patient-derived sarcoma cell line epigenetics, genomics and pharmacology (2021) (1)
- Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly. (2021) (1)
- LibSBGN: Electronic Processing of SBGN maps (2011) (0)
- Distinct epigenetic features of differentiation-regulated replication origins (2016) (0)
- Carcinogen-induced activation of SV40 gene expression in a semi-permissive environment. (1992) (0)
- Faculty Opinions recommendation of DCAF14 promotes stalled fork stability to maintain genome integrity. (2021) (0)
- EMBO Conference on Replication and Segregation of Chromosomes, Geilo, Norway, June 16-20. Replication and segregation of chromosomes in the three domains of life: EMBO conference reports common grounds. Meeting report. (2009) (0)
- Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B (2023) (0)
- Faculty Opinions recommendation of Chromatin conformation regulates the coordination between DNA replication and transcription. (2018) (0)
- Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma (2022) (0)
- Abstract 4862: Histone deacetylase inhibition induces DNA damage, slows down replication forks and activates dormant origins (2010) (0)
- Faculty Opinions recommendation of MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. (2017) (0)
- Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicing (2022) (0)
- Faculty Opinions recommendation of SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations. (2020) (0)
- Faculty Opinions recommendation of Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin. (2020) (0)
- Abstract CT268: Targeting replication stress and chemotherapy resistance with a combination of sacituzumab govitecan and berzosertib: A phase I clinical trial (2023) (0)
- Appendix 1A Molecular Interaction Maps of DNA Replication (2006) (0)
- Faculty Opinions recommendation of Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. (2021) (0)
- BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks (2020) (0)
- Abstract 203: SCLC-CellMiner: An extensive cell line genomic and pharmacology resource identifies a subgroup of small cell lung cancers sensitive to targeted therapies and immunotherapies (2021) (0)
- ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer (2022) (0)
- ColoWeb: a resource for analysis of colocalization of genomic features (2015) (0)
- Faculty Opinions recommendation of Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (2019) (0)
- Eukaryotic Replication Origins and Initiation of DNA Replication (2010) (0)
- “U-Turn” Replication at Arrested Forks Leads to the Generation of Extrachromosomal Inverted Repeats (2020) (0)
- Faculty Opinions recommendation of 4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. (2020) (0)
- 417 The ATM-Chk2 kinase pathway: molecular interaction maps and therapeutic rationale (2004) (0)
- Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation (2022) (0)
- The differentially expressed gene signatures of the Cullin 3-RING ubiquitin ligases in neuroendocrine cancer. (2022) (0)
- Abstract 577: DNA replication origin of human alphoid centromere regions . (2013) (0)
- Faculty Opinions recommendation of BLM helicase facilitates telomere replication during leading strand synthesis of telomeres. (2015) (0)
- Faculty Opinions recommendation of 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage. (2019) (0)
- Faculty Opinions recommendation of The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization. (2021) (0)
- Author response: A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells (2020) (0)
- Carcinogen-Induced Gene Amplification and Gene Expression (2020) (0)
- Faculty Opinions recommendation of DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. (2019) (0)
- Faculty Opinions recommendation of Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. (2018) (0)
- The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin (2018) (0)
- Faculty Opinions recommendation of The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. (2019) (0)
- Faculty Opinions recommendation of Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. (2017) (0)
- DNA replication profiling by molecular combing on single DNA fibers (2022) (0)
- Abstract 2391: Centromeric chromatin alteration is associated with increase in alphoid array replication fork speed in ovarian cancer cell lines (2020) (0)
- Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer. (2020) (0)
- Effect of SIRT1 on the stability of extrachromosomals and the gene amplification (2017) (0)
- Faculty Opinions recommendation of PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer. (2018) (0)
- Faculty Opinions recommendation of Checkpoint activation of an unconventional DNA replication program in tetrahymena. (2015) (0)
- Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I (2022) (0)
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