Mitchell Lazar

Q: What Schools Are Affiliated With Mitchell Lazar

Mitchell Lazar is affiliated with the following schools: Yale University, Albert Einstein College of Medicine, University of Vigo, University of Edinburgh, Massachusetts Institute of Technology, University of Massachusetts Medical School, University of California, San Francisco, University of Pennsylvania, Harvard University

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Mitchell Lazar

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#3163

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#5180

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#1032

USA Rank

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#988

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#1597

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#330

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Philosophy

Mitchell Lazar's Degrees

Doctorate Medicine Harvard University

Why Is Mitchell Lazar Influential?

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According to Wikipedia, Mitchell Lazar is an endocrinologist and physician-scientist known for his discovery of the hormone resistin and his contributions to the transcriptional regulation of metabolism. Lazar is the Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases, and the Director of the Institute for Diabetes, Obesity and Metabolism at the University of Pennsylvania.

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Mitchell Lazar's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The hormone resistin links obesity to diabetes (2001) (4691)
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription (2000) (1745)
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* (2001) (1672)
The Many Faces of PPARγ (2005) (1198)
A Unified Nomenclature System for the Nuclear Receptor Superfamily (1999) (1152)
Forming functional fat: a growing understanding of adipocyte differentiation (2011) (1129)
Thyroid hormone receptors: multiple forms, multiple possibilities. (1993) (1111)
Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia (1998) (1064)
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006) (946)
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans (2005) (918)
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. (1994) (852)
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. (1999) (835)
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007) (773)
New developments in adipogenesis (2009) (770)
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. (2002) (755)
Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids (*) (1995) (735)
Regulation of Fasted Blood Glucose by Resistin (2004) (725)
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. (2008) (725)
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors (1999) (663)
A family of tissue-specific resistin-like molecules. (2001) (655)
How Obesity Causes Diabetes: Not a Tall Tale (2005) (631)
Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. (1998) (630)
A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism (2011) (620)
The many faces of PPARgamma. (2005) (607)
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3 (2001) (596)
Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site* (1997) (588)
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways (2007) (579)
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. (1994) (579)
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. (2004) (577)
An Inflammatory Cascade Leading to Hyperresistinemia in Humans (2004) (540)
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock (2006) (534)
Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO (1998) (533)
Resistin and obesity-associated insulin resistance (2002) (530)
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. (1997) (515)
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. (2000) (494)
Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner (2019) (480)
DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells (2008) (474)
International Union of Pharmacology. LXIII. Retinoid X Receptors (2006) (472)
Identification of a thyroid hormone receptor that is pituitary-specific. (1989) (467)
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. (2008) (454)
Transcriptional control of adipogenesis. (2003) (439)
The mechanism of action of thyroid hormones. (2000) (434)
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation (2010) (432)
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. (2012) (419)
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing (1989) (418)
PPARγ and the global map of adipogenesis and beyond (2014) (417)
Peroxisome proliferator-activated receptor γ in diabetes and metabolism (2004) (404)
The current biology of resistin (2004) (397)
A futile metabolic cycle activated in adipocytes by antidiabetic agents (2002) (395)
Nutrient Sensing Nuclear Receptors Coordinate Autophagy (2014) (390)
International Union of Pharmacology. LX. Retinoic Acid Receptors (2006) (375)
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. (2014) (370)
Circadian time signatures of fitness and disease (2016) (368)
Regeneration of fat cells from myofibroblasts during wound healing (2017) (356)
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. (1996) (355)
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. (2007) (350)
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. (2000) (339)
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. (2004) (336)
Interdomain communication regulating ligand binding by PPAR-γ (1998) (330)
The Health Risk of Obesity—Better Metrics Imperative (2013) (318)
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit (1989) (309)
Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. (2005) (308)
Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription (1997) (304)
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. (2000) (303)
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ* (1998) (299)
Transcriptional Repression by Nuclear Hormone Receptors (2000) (296)
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration (2012) (291)
Human resistin: found in translation from mouse to man (2011) (282)
Adipokines and the peripheral and neural control of energy balance. (2008) (278)
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. (1998) (277)
Nuclear Receptor Corepressor-Histone Deacetylase 3 Governs Circadian Metabolic Physiology (2008) (273)
Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation* (1997) (271)
Activation of SOCS-3 by Resistin (2005) (270)
The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. (2005) (269)
A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis* (2000) (260)
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. (1990) (253)
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. (2011) (252)
Stoichiometric and steric principles governing repression by nuclear hormone receptors. (1997) (249)
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains (1996) (249)
Propagation of adipogenic signals through an epigenomic transition state. (2010) (244)
Proteasomal regulation of nuclear receptor corepressor-mediated repression. (1998) (242)
Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. (1994) (235)
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock (2015) (234)
Clocks, metabolism, and the epigenome. (2012) (234)
Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. (1988) (232)
The Nuclear Receptor Rev-erbα Controls Circadian Thermogenic Plasticity (2013) (228)
Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue (2018) (225)
Unraveling the Regulation of Hepatic Metabolism by Insulin (2017) (225)
Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor γ Function in Adipocytes and Macrophages (2010) (221)
Abnormal glucose homeostasis due to chronic hyperresistinemia. (2004) (216)
Activation of retinoic acid receptor‐α favours regulatory T cell induction at the expense of IL‐17‐secreting T helper cell differentiation (2007) (216)
Nuclear thyroid hormone receptors. (1990) (214)
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. (2015) (213)
The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat (1995) (213)
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. (2013) (211)
Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ (2013) (211)
The DRIP Complex and SRC-1/p160 Coactivators Share Similar Nuclear Receptor Binding Determinants but Constitute Functionally Distinct Complexes (2000) (209)
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. (2012) (208)
Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. (2004) (207)
The N-CoR/Histone Deacetylase 3 Complex Is Required for Repression by Thyroid Hormone Receptor (2003) (206)
Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. (2014) (205)
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element (1993) (205)
Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue (2006) (203)
Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. (2009) (201)
Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation. (1993) (199)
Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma (1996) (196)
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation (2003) (195)
A Potent Antidiabetic Thiazolidinedione with Unique Peroxisome Proliferator-activated Receptor γ-activating Properties* (1998) (194)
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response (2003) (192)
Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity (2003) (191)
Resistin- and Obesity-associated metabolic diseases. (2007) (188)
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo (2014) (185)
Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. (1999) (184)
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis (2013) (183)
Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. (1991) (178)
PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo (2007) (177)
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. (2006) (171)
Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo (2012) (169)
Brown Fat in Humans: Turning up the Heat on Obesity (2009) (165)
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. (2007) (164)
Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency (2006) (158)
Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor γ or Retinoid X Receptor α Deficiency (2011) (158)
Resistin: molecular history and prognosis (2003) (155)
Inhibition of Cellular Proliferation through IκB Kinase-Independent and Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of Cyclin D1 (2001) (153)
Mechanisms Regulating Adipocyte Expression of Resistin* (2002) (153)
Inflamed about obesity (2004) (151)
PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1 (2005) (151)
An open-label trial of the PPARγ ligand rosiglitazone for active ulcerative colitis (2001) (148)
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor (1991) (147)
Endogenous Ligands for Nuclear Receptors: Digging Deeper* (2010) (147)
Bacterial colonization leads to the colonic secretion of RELMbeta/FIZZ2, a novel goblet cell-specific protein. (2003) (146)
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions (2014) (144)
Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. (1997) (142)
Post-transcriptional Regulation of Thyroid Hormone Receptor Expression by cis-Acting Sequences and a Naturally Occurring Antisense RNA* (2000) (141)
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription (2018) (140)
Nuclear receptor Rev-erbα: a heme receptor that coordinates circadian rhythm and metabolism (2010) (139)
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. (2002) (139)
Structural elements of an orphan nuclear receptor-DNA complex. (1998) (137)
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo (2015) (136)
Dissociating fatty liver and diabetes (2013) (135)
Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction (2017) (135)
Determinants of CoRNR-Dependent Repression Complex Assembly on Nuclear Hormone Receptors (2001) (133)
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. (1992) (132)
Dimerization of Resistin and Resistin-like Molecules Is Determined by a Single Cysteine* (2001) (132)
Thyroid hormone action: a binding contract. (2003) (131)
Integrator regulates transcriptional initiation and pause release following activation. (2014) (131)
The Orphan Nuclear Receptor Rev-erbα Regulates Circadian Expression of Plasminogen Activator Inhibitor Type 1* (2006) (131)
Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist (2008) (128)
Circadian metabolism in the light of evolution. (2015) (125)
PPARγ, 10 years later (2005) (124)
Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. (1989) (123)
Modulating nuclear receptor function: may the phos be with you. (1999) (122)
Histone Deacetylase 3 Prepares Brown Adipose Tissue For Acute Thermogenic Challenge (2017) (121)
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes (2018) (119)
Nuclear receptor Rev-erbα: up, down, and all around (2014) (119)
Coactivators and Corepressors of NF-κB in IκBα Gene Promoter* (2005) (119)
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. (2010) (118)
Interdomain communication regulating ligand binding by PPAR-gamma. (1998) (118)
Thiazolidinedione Activation of Peroxisome Proliferator-activated Receptor γ Can Enhance Mitochondrial Potential and Promote Cell Survival* (2002) (115)
ETO interacting proteins (2004) (114)
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program (2015) (114)
Bifunctional Role of Rev-erbα in Adipocyte Differentiation (2008) (113)
Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes. (1993) (113)
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. (2009) (113)
Oligomerization of ETO Is Obligatory for Corepressor Interaction (2001) (112)
A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression (1999) (112)
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum Ca2+ATPase gene. Demonstration that retinoid X receptor binds 5' to thyroid hormone receptor in response element 1. (1994) (109)
Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation. (1997) (109)
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. (2006) (108)
Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha. (2009) (107)
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. (2000) (107)
The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2 (1997) (107)
A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. (1994) (105)
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo (2015) (105)
Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. (2009) (103)
Widespread distribution of immunoreactive thyroid hormone beta 2 receptor (TR beta 2) in the nuclei of extrapituitary rat tissues. (1994) (102)
Nuclear receptor corepressors (2003) (99)
Mouse and Human Resistins Impair Glucose Transport in Primary Mouse Cardiomyocytes, and Oligomerization Is Required for This Biological Action* (2005) (99)
Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation (2008) (99)
Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development. (1997) (98)
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors (2005) (96)
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. (2003) (94)
E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erbα (2010) (94)
The humoral side of insulin resistance (2006) (93)
The histone‐binding code of nuclear receptor co‐repressors matches the substrate specificity of histone deacetylase 3 (2005) (91)
PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. (2005) (90)
Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. (2016) (89)
Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers (2014) (89)
Mechanisms by which Thiazolidinediones Enhance Insulin Action (1999) (88)
Integrative regulation of physiology by histone deacetylase 3 (2018) (88)
Central Resistin Induces Hepatic Insulin Resistance via Neuropeptide Y (2007) (88)
The orphan nuclear receptors at their 25-year reunion. (2013) (87)
Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding* (2010) (86)
SR9009 has REV-ERB–independent effects on cell proliferation and metabolism (2019) (85)
A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. (2013) (84)
Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle*♦ (2011) (83)
An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis. (2001) (82)
Retinol saturase promotes adipogenesis and is downregulated in obesity (2009) (82)
Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor γ and CCAAT/Enhancer-binding Proteins* (2009) (81)
Immunocytochemical delineation of thyroid hormone receptor beta 2-like immunoreactivity in the rat central nervous system. (1993) (81)
Genetic and epigenomic mechanisms of mammalian circadian transcription (2016) (80)
Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation (1995) (80)
Coactivators for the Orphan Nuclear Receptor RORα (1999) (79)
Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. (2001) (79)
HIV Protease Inhibitor‐Specific Alterations in Human Adipocyte Differentiation and Metabolism (2006) (76)
PPAR gamma, 10 years later. (2005) (76)
Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion (2016) (75)
Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome (2012) (73)
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types (2020) (73)
HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. (2016) (72)
Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression (1997) (71)
PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism (2018) (71)
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. (2007) (70)
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity (2019) (68)
Progress in cardiovascular biology: PPAR for the course (2001) (68)
The Coiled-coil Domain Is the Structural Determinant for Mammalian Homologues of Drosophila Sina-mediated Degradation of Promyelocytic Leukemia Protein and Other Tripartite Motif Proteins by the Proteasome* (2004) (68)
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues (2013) (66)
Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. (1997) (66)
Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription. (1990) (65)
Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract (2011) (65)
Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element. (1990) (65)
Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19. (1994) (64)
Re-expression of GATA2 Cooperates with Peroxisome Proliferator-activated Receptor-γ Depletion to Revert the Adipocyte Phenotype* (2009) (63)
Species-specific strategies underlying conserved functions of metabolic transcription factors. (2011) (61)
Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction (2010) (60)
Differential Gene Regulation by PPARγ Agonist and Constitutively Active PPARγ2 (2002) (60)
The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo. (2010) (59)
Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. (2005) (59)
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. (2008) (58)
Inflammatory Induction of Human Resistin Causes Insulin Resistance in Endotoxemic Mice (2011) (58)
Regulation of two c-erbA messenger ribonucleic acids in rat GH3 cells by thyroid hormone. (1988) (58)
Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. (2014) (58)
Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. (2016) (55)
The Dawn of the SPPARMs? (2002) (55)
The N‐CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor (2006) (54)
Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase. (1981) (54)
Dichotomous Engagement of HDAC3 Activity Governs Inflammatory Responses (2020) (54)
Peroxisome Proliferator-Activated Receptor γ1 Expression Is Induced during Cyclic Adenosine Monophosphate-Stimulated Differentiation of Alveolar Type II Pneumonocytes. (1997) (53)
The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. (2005) (52)
Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space. (2020) (52)
Retinoic acid prevents downregulation of ras recision gene/lysyl oxidase early in adipocyte differentiation. (1994) (51)
Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification (2011) (51)
A Chromatin Immunoprecipitation Screen Reveals Protein Kinase Cβ as a Direct RUNX1 Target Gene* (2004) (51)
Human resistin protects against endotoxic shock by blocking LPS–TLR4 interaction (2017) (51)
Maturing of the nuclear receptor family. (2017) (51)
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ (2017) (50)
Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone. (2005) (50)
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver (2013) (49)
Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells. (1990) (49)
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides (2017) (47)
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation (2013) (47)
HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms (2016) (46)
Becoming fat. (2002) (46)
Differential Gene Regulation by PPAR Agonist and Constitutively Active PPAR 2 (2002) (44)
Macrophage-Derived Human Resistin Is Induced in Multiple Helminth Infections and Promotes Inflammatory Monocytes and Increased Parasite Burden (2015) (44)
Circadian epigenomic remodeling and hepatic lipogenesis: lessons from HDAC3. (2011) (43)
Endogenous retinoid X receptors can function as hormone receptors in pituitary cells (1994) (43)
Coactivators for the orphan nuclear receptor RORalpha. (1999) (42)
Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells. (2002) (40)
Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. (1990) (40)
East meets West: an herbal tea finds a receptor. (2004) (39)
DNA-independent and DNA-dependent Mechanisms Regulate the Differential Heterodimerization of the Isoforms of the Thyroid Hormone Receptor with Retinoid X Receptor* (1996) (39)
Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19". (1994) (39)
How Now, Brown Fat? (2008) (39)
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression (2009) (39)
Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells (2011) (37)
ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis (2015) (37)
The unique C-termini of the thyroid hormone receptor variant, c-erbA alpha 2, and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties. (1992) (36)
Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. (2014) (36)
Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. (2008) (35)
Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion (2016) (34)
Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2. (2002) (34)
Selective antagonism of thyroid hormone action by retinoic acid. (1992) (33)
Sweet dreams for LXR. (2007) (32)
Targeting PPAR&ggr; in the epigenome rescues genetic metabolic defects in mice (2017) (32)
Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold (2019) (32)
De-Meaning of Metabolism (2012) (31)
DNA bending by thyroid hormone receptor: influence of half-site spacing and RXR. (1995) (31)
Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment. (2008) (30)
Induction of retinoic acid receptor-beta by retinoic acid is cell specific. (1993) (29)
Interconnections between circadian clocks and metabolism. (2021) (28)
Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. (2016) (28)
A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor-γ Activity (2007) (28)
The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling* (2016) (28)
Gaining weight: the Keystone Symposium on PPAR and LXR. (2005) (27)
Steroid and thyroid hormone receptors. (1991) (27)
Genetic backgrounds determine brown remodeling of white fat in rodents (2016) (27)
Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion (2019) (27)
A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass (2018) (27)
Interaction with host SGS 3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V 2 protein (2009) (27)
Rev‐erbα and the circadian transcriptional regulation of metabolism (2015) (25)
Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. (2019) (24)
The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks. (2006) (24)
Thyroid hormone decreases the expression of epidermal growth factor receptor. (1991) (23)
Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes (2020) (23)
Toxicity of overexpressed MeCP2 is independent of HDAC3 activity (2018) (22)
The Orphan Receptor Rev-ErbAot Activates Transcription via a Novel Response Element (22)
In vitro phosphorylation of a purified preparation of bovine corpus striatal tyrosine hydroxylase. (1978) (20)
Pruning of the Adipocyte Peroxisome Proliferator-Activated Receptor γ Cistrome by Hematopoietic Master Regulator PU.1 (2013) (18)
β‐Adrenergic receptors control brown adipose UCP‐1 tone and cold response without affecting its circadian rhythmicity (2018) (18)
FIZZ 2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract (2004) (18)
Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver. (2015) (17)
Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction. (2019) (16)
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease (2020) (15)
HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity (2020) (15)
Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis. (2018) (15)
Tyrosine hydroxylase activation. Comparison of in vitro phosphorylation and in vivo administration of haloperidol. (1982) (15)
Cell‐specific integration of nuclear receptor function at the genome (2013) (13)
Peroxisome proliferator-activated receptor gamma1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes. (1997) (13)
Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice. (2020) (12)
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. (2021) (12)
Nuclear hormone receptors: from molecules to diseases. (1999) (12)
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver (2021) (11)
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function (2021) (11)
A gut check for PPARγ (1998) (10)
Modelling metabolic diseases and drug response using stem cells and organoids (2022) (10)
Biochemical isolation and analysis of a nuclear receptor corepressor complex. (2003) (10)
Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer. (2013) (10)
TYROSINE HYDROXYLASE FROM BRAIN: PHOSPHORYLATION OF THE ENZYME BY CYCLIC AMP-DEPENDENT PROTEIN KINASE (1979) (9)
Reversing the curse on PPARγ. (2018) (9)
PPARy in Adipocyte Differentiation (1999) (8)
adjacent binding on a genome-wide scale and C / EBP factors orchestrate adipocyte biology via γ PPAR Material Supplemental (2008) (8)
Editorial: A Sweetheart Deal for Thyroid Hormone. (2000) (8)
Adipogenic hotspots: where the action is (2011) (8)
REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity (2021) (8)
Rev-erbs: Integrating Metabolism Around the Clock (2016) (8)
Erratum: Retinol Saturase promotes adipogenesis and is downregulated in obesity (Proc Natl Acad Sci USA (2009) 106 (1105-1110) (2009) (7)
Erratum: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch (Developmental Cell (2016) 36(3) (316–330) (S1534580716000368)(10.1016/j.devcel.2016.01.002)) (2016) (7)
Cell-Specific Determinants of PPARγ γγ γ Function in Adipocytes and Macrophages (2010) (6)
Fingered for a fat fate. (2010) (6)
Treatment of ulcerative colitis (UC) with PPARΓ ligands: Preliminary results of a pilot study (2000) (6)
Isoform-specific functions of PPARγ in gene regulation and metabolism (2022) (6)
c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats. (1993) (6)
CHAPTER 4 – Mechanism of Action of Hormones That Act on Nuclear Receptors (2011) (5)
Gene regulation: One man's food (2000) (5)
LC-MS and GC-MS based metabolomics platform for cancer research (2014) (4)
Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers. (2020) (4)
A sweetheart deal for thyroid hormone. (2000) (4)
Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism (2014) (3)
and Migration in Human Vascular Smooth Muscle Cells Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression (1998) (3)
Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. (2016) (3)
A gut check for PPARgamma. (1998) (3)
Circadian regulation of gene expression and metabolism in the liver. (2022) (3)
Dephosphorylation of purified brain tyrosine hydroxylase by rat striatal extracts (1983) (3)
Liver Transcriptome Dynamics During Hibernation Are Shaped by a Shifting Balance Between Transcription and RNA Stability (2021) (3)
A Hormone Sends Instant Messages to the Genome (2011) (3)
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis (2023) (2)
Monomeric Nuclear Receptors (1998) (2)
Antidiabetes wars: a new hope (2010) (2)
Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity (2022) (2)
Reevaluation of L-thyroxine dosage. (1986) (2)
A non-canonical-PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass (2018) (2)
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues (2013) (2)
deacetylases in a Sin 3-independent repression pathway Nuclear receptor corepressors partner with class II histone (2000) (2)
Double SET point: G9a makes its mark in adipogenesis (2012) (2)
The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor. (1989) (1)
Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis (2022) (1)
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver (2013) (1)
Shining light on dark matter in the genome (2019) (1)
Chapter 3 – Principles of Hormone Action (2016) (1)
The Regulation of Tyrosine Hydroxylase Activity by Phosphorylation (1982) (1)
Transcriptional coordination of circadian and metabolic physiology (2014) (1)
When is a thyroid hormone receptor not a thyroid hormone receptor? (1996) (1)
Chapter 13 - Molecular Mechanisms of Thyroid Hormone Action (1997) (1)
LC-MS and GC-MS based metabolomics platform for cancer research (2014) (1)
Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock (2022) (1)
TM-06MYC AND MYCN DISRUPTION OF THE MOLECULAR CLOCK IN CANCER CELLS (2014) (1)
Nuclear Receptor Corepressors and Metabolism (2008) (0)
Citation for the 1999 Edwin B. Astwood Lecture Award of the Endocrine Society to Dr. David D. Moore. (1999) (0)
RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure (2023) (0)
Control of brown adipose thermogenesis by a cold-inducible, circadian mitochondrial transporter (2018) (0)
Genetic Variation Determines PPAR g Function and Anti-diabetic Drug Response In Vivo Graphical (0)
Genome-wide analysis of enhancer-RNA transcription reveals regulatory mechanisms by an anti-diabetic drug in adipocyte (2014) (0)
Characterization of PPAR-gamma 1 and PPAR-gamma 2 in Knockin and Knockout Mouse Models (2019) (0)
Thiazolidinediones and PGJ(2) have depot-specific effects on human pre-adipocyte differentiation. (1997) (0)
OR043 Obesity disrupts tissue-protective macrophage populations in the adipose and lung (2017) (0)
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides (2017) (0)
Integrative regulation of physiology by histone deacetylase 3 (2018) (0)
RELM-beta is a novel intestine-specific secreted protein that is expressed in the colonic crypt epithelium (2001) (0)
The great repression: Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression (2001) (0)
Muscle Gene in Heart and Skeletal Hdac 3 the Diet-induced Lethality Due to Deletion of Gene Regulation : (2011) (0)
100% fat:The Keystone Symposium on The Adipose Cell, Park City, Utah, USA, 15–21 January 1997 (1997) (0)
Bifunctional Role of Rev-erb (cid:2) in Adipocyte Differentiation (cid:1) (2008) (0)
Phosphorylated MED1 links transcription recycling and cancer growth (2022) (0)
Solution Structure of the SMRT Deacetylase Activation Domain (2005) (0)
Thyroid Hormone Action in Liver: A Coregulator Shift Rather Than the Canonical Switch (2021) (0)
901 HDAC3 complexes with KLF4 and NCoR/SMRT to control epidermal gene expression (2019) (0)
The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease (2022) (0)
Targeting Hdac3 limits foam cell formation and improves atherosclerotic plaque stability (2014) (0)
Abstract 4093: CXCL16 is Marker of Inflammation, Atherosclerosis and Acute Coronary Syndromes in Humans (NPAM Young Investigator Awardee) (2006) (0)
modulating Aurora B kinase activity A novel histone deacetylase pathway regulates mitosis by (2008) (0)
Better Metrics Imperative − − The Health Risk of Obesity (2013) (0)
HDAC 3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-1792 and TGF-b Signaling Regulation Graphical (2016) (0)
Reply to “A “futile cycle” induced by thiazolidinediones in human adipose tissue?” (2003) (0)
Mechanisms by which Thiazolidinediones Enhance Insulin (1999) (0)
The human protein resistin drives detrimental inflammatory monocyte responses in helminth infection (MPF7P.710) (2015) (0)
100% fat ?, 15–21 ? 1997 (1997) (0)
219-LB: The Hepatocyte Clock and Feeding Interdependently Control Chrono-Homeostasis of Multiple Liver Cell Types (2020) (0)
MON-LB017 Natural Genetic Variation in Humans Determines Basal and PPAR-Inducible Expression of PM20D1, a Putative Thermogenic Gene (2019) (0)
Glucocorticoid Resistance (1994) (0)
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity (2019) (0)
Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor (2022) (0)
Hepatocyte SREBP signaling mediates clock communication within the liver. (2023) (0)
673 Histone Deacetylase 3 coordinates protein and lipid synthesis to establish a functional epidermal barrier (2016) (0)
Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor (cid:1) / (cid:2) (NR1C2) Antagonist (2008) (0)
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression Running title: Regulation of Resistin by ER Stress (2009) (0)
Up, down, and all around the epigenomic regulation of metabolism (2012) (0)
Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue (2022) (0)
Toxicity of overexpressed MeCP 2 is independent of HDAC 3 activity (2018) (0)
Editorial Board (2009) (0)
SfE Transatlantic Medal Lecture (2014) (0)

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