Mitsuaki Yoshida
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Japanese virologist
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Mitsuaki Yoshidabiology Degrees
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Biology
Mitsuaki Yoshida's Degrees
- Bachelors Biology University of Tokyo
- Masters Virology University of Tokyo
- PhD Virology University of Tokyo
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Why Is Mitsuaki Yoshida Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mitsuaki Yoshida was a Japanese virologist known for identifying the molecular structure of Human T-lymphotropic virus 1 responsible for Adult T-cell leukemia/lymphoma. Life Yoshida was born in Toyama, Japan and received his Ph.D. in 1967 from the University of Tokyo. After his postdoctoral fellowship at MRC Laboratory of Molecular Biology, he worked to uncover the relationship between oncovirus and carcinogenesis at the Cancer Institute, Japanese Foundation for Cancer Research from 1975 to 1989. He was appointed as Professor at the Institute of Medical Science, University of Tokyo in 1989, where he served as Dean from 1996 to 1998. After retiring from the University of Tokyo and becoming Professor Emeritus, he was Director at the Tsukuba Research Institute of BANYU Pharmaceutical Co. in Tsukuba and Director at the Cancer Chemotherapy Center, Japanese Foundation for Cancer Research.
Mitsuaki Yoshida's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering (1987) (430)
- Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells (1984) (286)
- Increased replication of HTLV‐I in HTLV‐I–associated myelopathy (1989) (186)
- HIV/HTLV gene nomenclature (1988) (162)
- Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis (2005) (142)
- Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control (1999) (131)
- VIRUSES DETECTED IN HTLV-I-ASSOCIATED MYELOPATHY AND ADULT T-CELL LEUKAEMIA ARE IDENTICAL ON DNA BLOTTING (1987) (127)
- Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 (1995) (124)
- Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro (1983) (118)
- Interlaboratory Comparison of the Dicentric Chromosome Assay for Radiation Biodosimetry in Mass Casualty Events (2008) (116)
- WHO 1st Consultation on the Development of a Global Biodosimetry Laboratories Network for Radiation Emergencies (BioDoseNet) (2009) (107)
- Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site (1999) (98)
- Protection of cynomolgus monkeys against infection by human T‐cell leukemia virus type‐I by immunization with viral env gene products produced in Escherichia coli (1987) (96)
- Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors1 (2008) (89)
- Polyclonal integration of HTLV‐I proviral DNA in lymphocytes from HTLV‐I seropositive individuals: an intermediate state between the healthy carrier state and smouldering ATL (1988) (85)
- Erratum: LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids (Human Molecular Genetics (1999) 8 (1209-1217)) (1999) (80)
- The second pX product p27 x‐III of HTLV‐1 is required for gag gene expression (1986) (77)
- Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability (2005) (77)
- Biological Dosimetry by the Triage Dicentric Chromosome Assay: Potential Implications for Treatment of Acute Radiation Syndrome in Radiological Mass Casualties (2011) (73)
- Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain (1997) (61)
- Uninfected avian cells contain structurally unrelated progenitors of viral sarcoma genes (1980) (61)
- Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome (1998) (56)
- Crucial Role of C‐Myc in the Generation of Induced Pluripotent Stem Cells (2011) (55)
- Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles (2019) (55)
- Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. (2003) (55)
- Activity concentrations of environmental samples collected in Fukushima Prefecture immediately after the Fukushima nuclear accident (2013) (52)
- Down-regulation of vascular endothelial growth factor in renal cell carcinoma cells by glucocorticoids (2004) (51)
- The Chromosome Network for biodosimetry in Japan (2007) (48)
- Failure to detect HTLV‐I by in situ hybridization in the biopsied muscles of viral carriers with polymyositis (1992) (46)
- Biological Dosimetry by the Triage Dicentric Chromosome Assay - Further validation of International Networking. (2011) (44)
- T3 surface molecules on adult T cell leukemia cells are modulated in vivo (1986) (43)
- lymphoma type adult T‐cell leukemia—a clinicopathologic study of HTLV related T‐cell type malignant lymphoma (1986) (43)
- Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. (2002) (36)
- Cytogenetic Effects of Quercetin on Cultured Mammalian Cells (1980) (35)
- A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities (2012) (34)
- In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion (1994) (33)
- Molecular Cytogenetic Analysis of 17 Renal Cancer Cell Lines: Increased Copy Number at 5q31‐33 in Cell Lines from Nonpapillary Carcinomas (2000) (32)
- Increase in dicentric chromosome formation after a single CT scan in adults (2015) (31)
- Inhibition of translation initiation complex formation by MS1 (1972) (30)
- Molecular approach to human leukemia: Isolation and characterization of the first human retrovirus HTLV-1 and its impact on tumorigenesis in Adult T-cell Leukemia (2010) (28)
- Induction of genomic instability and activation of autophagy in artificial human aneuploid cells. (2016) (24)
- Synthesis of 1-(β-D-Ribofuranosyl) urea and Related Compounds. (1964) (23)
- The Dose Response of Chromosome Aberrations in Human Lymphocytes Induced In Vitro by Very Low-Dose γ Rays (2011) (23)
- Individual Radiation Exposure Dose Due to Support Activities at Safe Shelters in Fukushima Prefecture (2011) (23)
- Dose–response curves for analyzing of dicentric chromosomes and chromosome translocations following doses of 1000 mGy or less, based on irradiated peripheral blood samples from five healthy individuals (2017) (21)
- The nucleotide sequence of tRNAGly from yeast (1973) (21)
- Interaction of Gli2 with CREB Protein on DNA Elements in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type 1 Is Responsible for Transcriptional Activation by Tax Protein (1999) (21)
- Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines. (2003) (20)
- Chromosome Changes in Desmoid Tumors Developed in Patients with Familial Adenomatous Polyposis (1991) (20)
- Characterization of mRNA Expression of IκBα and NF‐κB Subfamilies in Primary Adult T‐cell Leukemia Cells (1998) (20)
- A gag‐env Hybrid Protein of Human T‐cell Leukemia Virus Type I and Its Application to Serum Diagnosis (1988) (17)
- Multiple targets of HTLV-1 for dysregulation of host cells (1996) (17)
- Leucine zipper structure oftheprotein CRE-BP1binding tothecyclic AMP response element inbrain (1989) (16)
- Fetal Irradiation of Rats Induces Persistent Translocations in Mammary Epithelial Cells Similar to the Level after Adult Irradiation, but not in Hematolymphoid Cells (2014) (16)
- Analysis of chromosome translocation frequency after a single CT scan in adults (2016) (15)
- Simulation-based analyses reveal stable microsatellite sequences in human pancreatic cancer. (2009) (15)
- Rearrangements of Chromosome 3 in Nonfamilial Renal Cell Carcinomas from Japanese Patients (1988) (15)
- Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy. (2008) (14)
- A novel parameter, cell-cycle progression index, for radiation dose absorbed estimation in the premature chromosome condensation assay. (2014) (14)
- HTLV-1 oncoprotein Tax deregulates transcription of cellular genes through multiple mechanisms (2005) (13)
- Chromosome Aberrations and Sister Chromatid Exchanges Induced by Tryptophan Pyrolysates, Trp-P-1 and Trp-P-2, in Cultured Human and Chinese Hamster Cells (1980) (13)
- Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation (2019) (12)
- Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells (2018) (11)
- Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts (2014) (11)
- Construction of fluorescence in situ hybridization (FISH) translocation dose-response calibration curve with multiple donor data sets using R, based on ISO 20046:2019 recommendations (2019) (9)
- Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (Procyon lotor). (2020) (8)
- No Evidence of HTLV‐1 Infection in Japanese Multiple Sclerosis Patients in Polymerase Chain Reaction (1989) (8)
- Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas. (2007) (8)
- CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1 (1988) (7)
- A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients (2016) (7)
- Cytogenetic Studies on Colon Carcinomas and Adenomas from Patients with Familial Polyposis Coli (1990) (7)
- Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells (2017) (7)
- Case Report: Upper Respiratory Tract Involvement in Adult T-Cell Leukemia (1988) (6)
- Expression of HTLV-I gag Protein in Escherichia coli (1988) (5)
- Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients (2019) (5)
- Preface to 25 years of HTLV-1 and ATL research (2005) (5)
- Adult T‐cell Leukemia in Spouses (1989) (5)
- Effects of Colcemid-Block on Chromosome Condensation in Metaphase Analysis and Premature Chromosome Condensation Assays (2012) (5)
- A Mouse Erythroleukemia Cell Line Possessing Friend Spleen Focus‐forming Virus gp55 Transgene and Temperature‐sensitive Mutant p53 Gene (1995) (5)
- Assessment of chromosome aberrations in large Japanese field mice (Apodemus speciosus) in Namie Town, Fukushima (2020) (5)
- Improved harvest and fixation methodology for isolated human peripheral blood mononuclear cells in cytokinesis-block micronucleus assay (2020) (4)
- TheIndirect Association ofHumanT-Cell LeukemiaVirus tax Protein withDNA Results inTranscriptional Activation (1991) (4)
- Heterochronous occurrence of microsatellite instability in multiple myeloma – an implication for a role of defective DNA mismatch repair in myelomagenesis (2018) (4)
- Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells (2018) (3)
- Detailed chromosome analysis of wild-type, immortalized fibroblasts with SV40T, E6E7, combinational introduction of cyclin dependent kinase 4, cyclin D1, telomerase reverse transcriptase (2021) (3)
- High-incidence spontaneous tumors in JF1/Ms mice: relevance of hypomorphic germline mutation and subsequent promoter methylation of Ednrb (2013) (3)
- Identification of Proteins Specific to Friend Strain of Spleen Focus forming Virus (SFFV) (1978) (3)
- Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation (2020) (3)
- Influence of anticoagulants and storage temperatures on blood counts and mitotic index of blood samples collected for cytogenetic biodosimetry (2018) (2)
- Mystery of Human T-cell Leukemia Virus Type 1: Commentary on Two Viral Genes, Tax and HBZ (2014) (2)
- Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat (2010) (2)
- MOLECULAR BIOLOGY OF HTLV-1: PLEIOTROPIC FUNCTION OF Tax PROTEIN IN CELL REGULATION (2003) (2)
- Alteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues (2009) (2)
- Precision of scoring radiation-induced chromosomal aberrations and micronuclei by unexperienced scorers (2019) (2)
- Rapid isolation of murine primary hepatocytes for chromosomal analysis (2017) (2)
- Cytokinesis-block micronucleus assay performed in 0 and 2 Gy irradiated whole blood and isolated PBMCs in a six-well transwell co-culture system (2021) (2)
- Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas (2009) (2)
- A UniqueEnhancer Element forthetransActivator (p4otax) of HumanT-Cell Leukemia Virus TypeIThatIsDistinct fromCyclic AMP-and12-0-Tetradecanoylphorbol- 13-Acetate-Responsive Elements (1989) (1)
- Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability (2020) (1)
- Laboratory Automation for Cytogenetic Biodosimetry and Inter-Laboratory Comparison of the Dicentric Assay (2008) (1)
- Chromosome abnormalities in colon carcinomas and adenomas from patients with familial polyposis coli (1989) (1)
- Transition of Radioactive Cesium Deposition in Reproductive Organs of Free-Roaming Cats in Namie Town, Fukushima (2021) (1)
- Two Step Activation of the Interleukin-2 Autocrine Loop May be Involved in ATL Development (1987) (1)
- Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation (2022) (1)
- T-Cell Activation Signals andHumanT-Cell LeukemiaVirusType I-Encoded p40xProtein Activate theMouseGranulocyte- Macrophage Colony-Stimulating Factor Genethrough a Common (1988) (1)
- Peroxidase-positive acute leukemia with T-cell markers (1980) (1)
- Overlap of the p 53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I ( tumor-suppressor gene / transcriptional activation / DNA binding / functional domains / point mutants ) (1)
- Modified C-band technique for the analysis of chromosome abnormalities in irradiated human lymphocytes (2011) (1)
- 1 – Positive and Negative Regulation of Human T-cell Leukemia Virus Type I (HTLV-I) Gene Expression and Replication: Function of the rex Gene (1991) (1)
- HTLV-1 infection and abnormal cell growth (1999) (0)
- Expression of HTLV-IgagProtein inEscherichia coli (1988) (0)
- Induction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA (1988) (0)
- Chromosome analyses in mouse thymic lymphoma induced by carbon beam (2005) (0)
- HUMAN T-CELL LEUKEMIA VIRUSES (RETROVIRIDAE) | HTLV-1 (1999) (0)
- leukemia virus type I. mice that harbor pX genes of human T-cell Thymic atrophy characteristic in transgenic (2013) (0)
- Effects of carbon-ion radiation on heterogeneous tumors---Comparison between combinations (2009) (0)
- Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells (2017) (0)
- P-9. Molecular characterization and chromosomal distribution of short interspersed nuclear elements (SINEs) like sequences isolated from the greater Japanese shrew-mole (Urotrichus talpoides)(Abstracts of the oral and poster presentations, Abstract of the 56th Annual Meeting of The Society of Chromo (2006) (0)
- Homopoietic histocompatibility (Hh-1) phenotype and the regulation of its expression (2004) (0)
- Abstract 853: Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT scans (2018) (0)
- Human T-cell Leukemia Virus Type-l ( HTLV-1 ) Tax Is Expressed at the Same Level in Infected Cells of HTLV-l-Associated Myelopathy or Tropical Spastic Paraparesis Patients as in Asymptomatic Carriers but at a Lower Level in Adult T-cell Leukemia Cells (2002) (0)
- Cytogenetic Definition of Kidney Tumors (1987) (0)
- ThymicAtrophy Characteristic inTransgenic MiceThatHarborpX GenesofHumanT-Cell Leukemia VirusTypeI (1989) (0)
- P-137 The characteristics of chromosome abnormalities of mouse thymic lymphoma caused by X-irradiation at 1 week of age(Poster Session) (2008) (0)
- Deletion of chromosomes 11 and 12 in X-ray induced mouse thymic lymphoma (2004) (0)
- MOLECULAR BIOLOGY OF HTLV-1: MOLECULAR INTERACTION OF VIRAL AND HOST CELL FACTORS (1999) (0)
- Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells (2018) (0)
- Exosome-like vesicles released from ob/ob mouse adipose tissue enhance cell survival of cells with radiation-induced genomic instability (2023) (0)
- P-12. Structural abnormalities of chromosomes 11 and 12 in X-ray induced mouse thymic lymphoma(Abstracts of the oral and poster presentations) (2006) (0)
- Radiation emergency medical preparedness for cytogenetic biodosimetry in Hirosaki University, Japan (2021) (0)
- 663 Age dependence of T-cell lymphoma induction by radiation exposure in Mlh1-deficient mice (2010) (0)
- Chromosome 3p rearrangements in renal cell adenocarcinomas from 31 Japanese patients (1989) (0)
- Cyclin-Dependent Kinase Inhibitors Rheumatoid Arthritis with Small-Molecule Successful Treatment of Animal Models of (2008) (0)
- antigen peptide adult-T-cell leukemiavirus derivative of. (1985) (0)
- Rapid isolation of murine primary hepatocytes for chromosomal analysis (2017) (0)
- High-Resolution Banding of the Mouse Chromosomes (1983) (0)
- Involvement of Human Retrovirus in Specific T-Cell Leukemia (1987) (0)
- Transcriptional (p40x) andpost-transcripti onal (p27x-III) regulators arerequired fortheexpression andreplication ofhumanT-cell leukemia virus typeIgenes (pXgenefunction/gag expression/spllcing/trans-activation) (1987) (0)
- Adult t-cell leukemiavirus antigen polypeptide. (1985) (0)
- p 27 XIII and p 21 x-" " ' , proteins encoded by the pX sequence of human T-cell leukemia virus type I ( pX gene products / overlapping gene / nuclear localization / transactivation ) (0)
- Establishment of Induced Pluripotent Stem Cells from Lymph Node B Cells and Induction of Aid Expression in Their Differentiation into Hematopoietic Stem Cells (2016) (0)
- Analysis of Radioactive Elements in Testes of Large Japanese Field Mice Using an Electron Probe Micro-Analyser after the Fukushima Accident (2019) (0)
- Overlap ofthep53-responsive element andcAMP-responsive element intheenhancer ofhumanT-cell leukemia virus typeI (1992) (0)
- leukemia virus type 1 Tax through a variant cAMP-responsive element Transactivation of the fucosyltransferase VII gene by human T-cell (2002) (0)
- Manual Scoring with Shortened 48 h Cytokinesis-Block Micronucleus Assay Feasible for Triage in the Event of a Mass-Casualty Radiation Accident (2023) (0)
- Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles (2019) (0)
- Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation (2022) (0)
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