Mitsuru Hashida
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Computer Science
Mitsuru Hashida's Degrees
- PhD Computer Science Imperial University of Japan
- Masters Computer Engineering Kyoto University
- Bachelors Electrical Engineering Osaka University
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(Suggest an Edit or Addition)Mitsuru Hashida's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake (1995) (365)
- In vitro cytotoxicity of macromolecules in different cell culture systems (1995) (311)
- Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase). (1998) (251)
- Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes (2000) (246)
- Luminescent proteins for high-speed single-cell and whole-body imaging (2012) (245)
- The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier (2000) (245)
- Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution (1996) (183)
- Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting. (2006) (178)
- Cell-specific delivery of genes with glycosylated carriers. (2001) (173)
- Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression. (2000) (173)
- Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. (2009) (173)
- Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid (2001) (168)
- In Vivo Gene Delivery to the Liver Using Novel Galactosylated Cationic Liposomes (2000) (162)
- Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver. (2003) (160)
- In silico approaches for predicting ADME properties of drugs. (2004) (160)
- Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes. (1995) (158)
- Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes. (1998) (154)
- Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes. (2012) (151)
- The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: the relation to the lipophilicity of the drug. (1991) (145)
- Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system (2000) (143)
- Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity (1991) (141)
- Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide. (2008) (141)
- Disposition Characteristics of Macromolecules in Tumor-Bearing Mice (1990) (140)
- Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. (2007) (139)
- Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties. (1998) (136)
- Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine). (1998) (136)
- Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats. (2008) (135)
- Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution. (1999) (134)
- Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives. (2001) (133)
- Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape. (2010) (131)
- Strategies for In Vivo Delivery of siRNAs (2010) (131)
- Nonviral vectors for in vivo gene delivery: physicochemical and pharmacokinetic considerations. (1997) (128)
- Long circulating emulsion carrier systems for highly lipophilic drugs. (1994) (126)
- Creation of pure nanodrugs and their anticancer properties. (2012) (122)
- Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice. (2000) (121)
- Effect of Particle Size and Charge on the Disposition of Lipid Carriers After Intratumoral Injection into Tissue-isolated Tumors (2004) (120)
- In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes. (1995) (118)
- Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures. (2001) (117)
- Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer. (1997) (117)
- PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice. (2006) (115)
- Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations (2011) (115)
- Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives. (1992) (113)
- Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives. (1999) (113)
- Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs. (1995) (111)
- Structure-activity relationship of 1-alkyl- or 1-alkenylazacycloalkanone derivatives as percutaneous penetration enhancers. (1988) (108)
- Pharmacokinetic considerations for targeted drug delivery. (2013) (107)
- Factors affecting drug and gene delivery: effects of interaction with blood components. (2002) (107)
- Nonviral approaches satisfying various requirements for effective in vivo gene therapy. (2002) (106)
- Targeted delivery systems of small interfering RNA by systemic administration. (2007) (106)
- Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion (1987) (103)
- Gene expression and antitumor effects following direct interferon (IFN)-γ gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice (1999) (102)
- Macromolecule-drug conjugates in targeted cancer chemotherapy. (1984) (101)
- Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice. (2004) (100)
- Ultrasound induced cancer immunotherapy. (2014) (100)
- Mitomycin C‐dextran conjugate: a novel high molecular weight pro‐drug of mitomycin C (1980) (100)
- Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite. (2014) (97)
- Evaluation of Proinflammatory Cytokine Production Induced by Linear and Branched Polyethylenimine/Plasmid DNA Complexes in Mice (2006) (96)
- Lipid carrier systems for targeted drug and gene delivery. (2005) (94)
- Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration. (2006) (94)
- Effects of β-cyclodextrin and di-O-methyl-β-cyclodextrin on the percutaneous absorption of butylparaben, indomethacin and sulfanilic acid (1986) (93)
- Enhanced lymphatic delivery of mitomycin C conjugated with dextran. (1984) (91)
- Effects of skin metabolism on percutaneous penetration of lipophilic drugs. (1997) (90)
- piggyBac Transposon-mediated Long-term Gene Expression in Mice (2010) (90)
- Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system. (2001) (90)
- Mechanistic and empirical modeling of skin permeation of drugs. (2003) (87)
- Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine). (1997) (87)
- Effect of galactose density on asialoglycoprotein receptor-mediated uptake of galactosylated liposomes. (2005) (86)
- Effect of mannose density on mannose receptor-mediated cellular uptake of mannosylated O/W emulsions by macrophages. (2006) (85)
- The role of dioleoylphosphatidylethanolamine (DOPE) in targeted gene delivery with mannosylated cationic liposomes via intravenous route. (2005) (84)
- The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration. (2001) (83)
- Development of an antigen-presenting cell-targeted DNA vaccine against melanoma by mannosylated liposomes. (2007) (83)
- Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells. (2007) (80)
- Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns (2012) (79)
- Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data (2013) (79)
- Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy. (2010) (78)
- Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy. (2010) (77)
- Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion. (1992) (77)
- Inhibition of Metastatic Tumor Growth in Mouse Lung by Repeated Administration of Polyethylene Glycol-Conjugated Catalase (2004) (76)
- Novel galactosylated liposomes for hepatocyte-selective targeting of lipophilic drugs. (2001) (74)
- Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages. (1998) (74)
- Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice (1987) (73)
- Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes. (2002) (72)
- Pharmacokinetics of receptor-mediated hepatic uptake of glycosylated albumin in mice (1992) (71)
- Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties. (1995) (69)
- Inhibition of experimental pulmonary metastasis by controlling biodistribution of catalase in mice (2002) (68)
- Pharmacokinetic evaluation of polymeric carriers (1996) (68)
- The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes (2002) (68)
- Disposition and pharmacokinetics of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the rat. (1984) (68)
- Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. (2011) (67)
- Efficient Gene Transfer into Macrophages and Dendritic Cells by in Vivo Gene Delivery with Mannosylated Lipoplex via the Intraperitoneal Route (2006) (66)
- Targeted and sustained drug delivery using PEGylated galactosylated liposomes. (2003) (66)
- Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuscular administration (1987) (65)
- Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes. (2005) (64)
- Targeting Efficiency of Galactosylated Liposomes to Hepatocytes in Vivo: Effect of Lipid Composition (2002) (63)
- Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation. (2004) (62)
- Mannosylated semiconductor quantum dots for the labeling of macrophages. (2008) (62)
- Enhanced transfection efficiency into macrophages and dendritic cells by a combination method using mannosylated lipoplexes and bubble liposomes with ultrasound exposure. (2010) (62)
- Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. (2007) (62)
- Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice (2004) (62)
- Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities (1987) (62)
- Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors. (2002) (61)
- Glycosylated cationic liposomes for cell-selective gene delivery. (2002) (60)
- Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model (2008) (59)
- PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal. (2006) (59)
- Prediction of human skin permeability using a combination of molecular orbital calculations and artificial neural network. (2002) (59)
- Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells. (2010) (59)
- Cationic charge-dependent hepatic delivery of amidated serum albumin. (2005) (58)
- Glycosylation-mediated targeting of carriers. (2014) (58)
- Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans. (2001) (58)
- Prediction of Caco-2 cell permeability using a combination of MO-calculation and neural network. (2002) (57)
- Disposition of oligonucleotides in isolated perfused rat kidney: involvement of scavenger receptors in their renal uptake. (1996) (56)
- Soluble macromolecular carriers for the delivery of antitumour drugs (1989) (56)
- Pharmacokinetics and targeted delivery of proteins and genes (1996) (56)
- Disposition characteristics of emulsions and incorporated drugs after systemic or local injection. (2000) (56)
- Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate. (1999) (55)
- Inhibition of liver metastasis by targeting of immunomodulators using mannosylated liposome carriers. (2002) (55)
- Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo (2005) (54)
- Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor. (2004) (54)
- Enhanced DNA vaccine potency by mannosylated lipoplex after intraperitoneal administration (2006) (54)
- Controlled biodistribution of galactosylated liposomes and incorporated probucol in hepatocyte-selective drug targeting. (2000) (54)
- Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation. (2011) (53)
- Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity. (1983) (53)
- Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. (2016) (53)
- Development of targeted delivery systems for nucleic acid drugs. (1997) (52)
- Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. (2003) (52)
- Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection. (1998) (51)
- Induction of apoptosis in A549 human lung cancer cells by all-trans retinoic acid incorporated in DOTAP/cholesterol liposomes. (2006) (51)
- Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis (1997) (50)
- Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method. (2002) (50)
- Development of a biochip with serially connected pneumatic balloons for cell-stretching culture (2011) (50)
- Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation (2005) (49)
- In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein. (2001) (49)
- Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver (1991) (48)
- Characterization of Plasmid DNA Binding and Uptake by Peritoneal Macrophages from Class A Scavenger Receptor Knockout Mice (1999) (48)
- Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: poly C in a murine lung metastasis model (2003) (48)
- Control of pharmacokinetic profiles of drug—macromolecule conjugates (1996) (47)
- Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate. (1986) (47)
- Influence of Physicochemical Properties on Pharmacokinetics of Non-viral Vectors for Gene Delivery (2002) (47)
- Physico-chemical and antitumor characteristics of high molecular weight prodrugs of mitomycin C. (1982) (47)
- Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells. (2011) (47)
- Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. (2012) (46)
- Development of gene drug delivery systems based on pharmacokinetic studies. (2001) (46)
- Synthesis and Pharmacokinetics of a New Liver-Specific Carrier, Glycosylated Carboxymethyl-Dextran, and Its Application to Drug Targeting (2004) (45)
- Microfluidic devices for construction of contractile skeletal muscle microtissues. (2015) (45)
- Prodrugs of 6-thiopurines: enhanced delivery through the skin. (1983) (45)
- Disposition Characteristics of Plasmid DNA in the Single-pass Rat Liver Perfusion System (1996) (45)
- Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells. (2004) (45)
- Controlled biodistribution of highly lipophilic drugs with various parenteral formulations. (1993) (45)
- Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex. (2006) (45)
- Pharmacokinetics and In Vivo Gene Transfer of Plasmid DNA Complexed with Mannosylated Poly(L-Lysine) in Mice (2000) (45)
- Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. (1990) (45)
- Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats. (1999) (45)
- Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate. (1992) (44)
- Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats. (2001) (44)
- Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver. (2001) (44)
- Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes (2006) (44)
- Analysis of skin penetration enhancement based on a two-layer skin diffusion model with polar and nonpolar routes in the stratum corneum: dose-dependent effect of 1-geranylazacycloheptan-2-one on drugs with different lipophilicities. (1993) (43)
- Development of nitric oxide donors for the treatment of cardiovascular diseases. (2007) (43)
- Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration. (2005) (43)
- Effects of various absorption promoters on pulmonary absorption of drugs with different molecular weights. (1993) (43)
- Optimization of tumor-selective targeting by basic fibroblast growth factor-binding peptide grafted PEGylated liposomes. (2007) (43)
- Theoretical considerations involving the pharmacokinetics of plasmid DNA. (2005) (43)
- Design of polymeric prodrugs of prostaglandin E(1) having galactose residue for hepatocyte targeting. (1999) (42)
- Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I: Synthesis and characterization. (1989) (42)
- Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism. (1994) (42)
- Liver targeting of catalase by cationization for prevention of acute liver failure in mice. (2006) (42)
- QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method (2003) (42)
- Renal press-mediated transfection method for plasmid DNA and siRNA to the kidney. (2008) (42)
- Control of in vivo fate of albumin derivatives utilizing combined chemical modification. (1994) (42)
- Prolonged release of bleomycin from parenteral gelatin sphere-in-oil-in-water multiple emulsion. (1982) (41)
- Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice. (1999) (41)
- Improvement of the Pulmonary Absorption of (Asu1,7)-Eel Calcitonin by Various Protease Inhibitors in Rats (1994) (41)
- Tissue-Specific Characteristics of in Vivo Electric Gene: Transfer by Tissue and Intravenous Injection of Plasmid DNA (2005) (41)
- Analysis of Hepatic Disposition of Galactosylated Cationic Liposome/Plasmid DNA Complexes in Perfused Rat Liver (2003) (40)
- The Accumulation Mechanism of Cationic Mitomycin C‐dextran Conjugates in the Liver: In‐vivo Cellular Localization and In‐vitro Interaction with Hepatocytes (1988) (40)
- Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats. (1996) (40)
- Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells. (2011) (40)
- The potential role of fucosylated cationic liposome/NFkappaB decoy complexes in the treatment of cytokine-related liver disease. (2007) (40)
- In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages. (2014) (40)
- Enhanced Gene Transfection in Macrophages Using Mannosylated Cationic Liposome-Polyethylenimine-Plasmid DNA Complexes (2001) (39)
- Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration. (2006) (39)
- Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice. (1995) (38)
- Intracellular drug delivery by genetically engineered high-density lipoprotein nanoparticles. (2010) (38)
- Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion Model (1994) (38)
- Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation. (1992) (38)
- Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: quantitative comparison with other hepatotropic ligands. (1999) (38)
- In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum Corneum (1994) (37)
- Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages. (2001) (37)
- Experimental study on lymphatic vascular changes in the development of cancer. (1981) (37)
- Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes. (2006) (37)
- Efficient suppression of murine intracellular adhesion molecule‐1 using ultrasound‐responsive and mannose‐modified lipoplexes inhibits acute hepatic inflammation (2012) (37)
- Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells. (1998) (37)
- Studies on pharmaceutical modification of anticancer agents. II. Enhanced delivery of bleomycin into lymph by emulsions and drying emulsions. (1975) (36)
- Use of lipoplex‐induced nuclear factor‐κB activation to enhance transgene expression by lipoplex in mouse lung (2006) (36)
- Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice (2010) (36)
- Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control. (2009) (36)
- Pharmacokinetics in design of polymeric drug delivery systems (1994) (35)
- Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity. (2007) (35)
- Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS‐induced cytokine production in a murine liver failure model (2006) (35)
- SOD derivatives prevent metastatic tumor growth aggravated by tumor removal (2008) (34)
- Tumor growth suppression by the combination of nanobubbles and ultrasound (2016) (34)
- Demonstration of the Receptor‐mediated Hepatic Uptake of Dextran in Mice (1992) (34)
- Antitumor activity of mitomycin C-dextran conjugate against various murine tumors. (1981) (34)
- Effect of 1-alkyl- or 1-alkenylazacycloalkanone derivatives on the penetration of drugs with different lipophilicities through guinea pig skin. (1991) (34)
- Renal disposition characteristics of oligonucleotides modified at terminal linkages in the perfused rat kidney. (1995) (34)
- Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system. (1996) (33)
- Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system. (1990) (33)
- Mechanisms of hepatic disposition of polystyrene microspheres in rats: effects of serum depend on the sizes of microspheres. (1999) (33)
- Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells (2006) (32)
- Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model. (2015) (32)
- Analysis of Drug Penetration Through the Skin by the Two-Layer Skin Mode (1989) (32)
- A new method for assessment of drug disposition in muscle: Application of statistical moment theory to local perfusion systems (1985) (32)
- Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II: Biopharmaceutical and pharmacological properties. (1989) (32)
- Effect of absorption promoters on the nasal absorption of drugs with various molecular weights (1993) (32)
- Enhanced gene expression in lung by a stabilized lipoplex using sodium chloride for complex formation (2005) (32)
- Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice. (2009) (31)
- Inhibition of liver metastasis by all-trans retinoic acid incorporated into O/W emulsions in mice. (2006) (31)
- Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol. (1994) (31)
- Development of Novel Drug and Gene Delivery Carriers Composed of Single-Walled Carbon Nanotubes and Designed Peptides With PEGylation. (2016) (31)
- Analysis of in vivo skin penetration enhancement by oleic acid based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum (1995) (31)
- Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits. (1987) (31)
- Preservative activity and in vivo percutaneous penetration of butylparaben entrapped in liposomes. (1986) (31)
- Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles. (2009) (31)
- Prevention of Hepatic Ischemia/Reperfusion Injury by Prolonged Delivery of Nitric Oxide to the Circulating Blood in Mice (2008) (31)
- Exclusive photothermal heat generation by a gadolinium bis(naphthalocyanine) complex and inclusion into modified high-density lipoprotein nanocarriers for therapeutic applications. (2013) (30)
- Antitumor activity of lipophilic prodrugs of mitomycin C entrapped in liposome or O/W emulsion. (1984) (30)
- Hepatic targeting of drugs and proteins by chemical modification (1995) (30)
- Percutaneous absorption of butylparaben from liposomes in vitro. (1986) (30)
- Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice. (2010) (30)
- Development of a hepatocyte-specific prostaglandin E(1) polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice. (1999) (29)
- Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling. (2014) (29)
- Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase (2006) (29)
- Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase. (2009) (29)
- Biodistribution Characteristics of Galactosylated Emulsions and Incorporated Probucol for Hepatocyte-Selective Targeting of Lipophilic Drugs in Mice (2004) (29)
- Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex (2005) (29)
- Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics. (2010) (29)
- Important role of serum proteins associated on the surface of particles in their hepatic disposition. (2002) (29)
- Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery System (2014) (29)
- The effect of polysorbate 80 on brain uptake and analgesic effect of D-kyotorphin (1989) (29)
- Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice. (2004) (28)
- Hydrogen peroxide‐mediated nuclear factor κB activation in both liver and tumor cells during initial stages of hepatic metastasis (2008) (28)
- Uptake characteristics of galactosylated emulsion by HepG2 hepatoma cells. (2005) (28)
- Theoretical analysis of the effect of cutaneous metabolism on skin permeation of parabens based on a two-layer skin diffusion/metabolism model. (1999) (28)
- Key physiological phenomena governing transgene expression based on tissue pressure-mediated transfection in mice. (2010) (27)
- Tumor Localization and in vivo Antitumor Activity of the Immunoconjugate Composed of Anti‐human Colon Cancer Monoclonal Antibody and Mitomycin C‐Dextran Conjugate (1991) (27)
- Disposition characteristics of recombinant human interleukin-11 after a bolus intravenous administration in mice. (1995) (27)
- Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice. (2009) (27)
- Targeted Delivery of Prostaglandin E1 to Hepatocytes Using Galactosylated Liposomes (2000) (27)
- Evaluation of water in oil and microsphere in oil emulsions as a specific delivery system of 5-fluorouracil into lymphatics. (1977) (26)
- Use of mannosylated cationic liposomes/ immunostimulatory CpG DNA complex for effective inhibition of peritoneal dissemination in mice (2008) (26)
- In vivo Site-Specific Transfection of Naked Plasmid DNA and siRNAs in Mice by Using a Tissue Suction Device (2012) (26)
- High‐density lipoprotein mutant eye drops for the treatment of posterior eye diseases (2017) (26)
- Pharmacokinetic Analysis of Lectin-dependent Biodistribution of Fucosylated Bovine Serum Albumin: A Possible Carrier for Kupffer Cells (2001) (26)
- Absorption characteristics of the lipophilic prodrug of mitomycin C from injected liposomes or an emulsion (1985) (26)
- Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice (2005) (26)
- Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling. (2014) (26)
- Design for Cell-Specific Targeting of Proteins Utilizing Sugar-Recognition Mechanism: Effect of Molecular Weight of Proteins on Targeting Efficiency (1995) (26)
- Pressure-mediated transfection of murine spleen and liver. (2009) (26)
- Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice. (2010) (26)
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- Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate. (1998) (1)
- [Development of nucleic acid transfection technology to the kidney]. (2008) (1)
- Mechanical stimulator of cultured vascular endothelial cell for investigation of drug permeability of blood vessel (2011) (1)
- Characterization of mitomycin C-induced gastrointestinal damage. II. In vitro everted sac experiment. (1989) (1)
- Anti-MUC 1 Aptamer / Negatively Charged Amino Acid Dendrimer Conjugates for Targeted Delivery to Human Lung Adenocarcinoma A 549 Cells (2016) (1)
- STRAIN-GRADATION GENERATOR USING SERIALLY CONNECTED MICROBALLOONS FOR PARALLEL TESTING OF CELL-STRETCHING CULTURE (2010) (1)
- [Local administration of anti-cancer drugs]. (1984) (1)
- Pharmacokinetics in gene delivery (2005) (1)
- Pharmacokinetics of polymer-plasmid DNA complex (2004) (1)
- QSPR analysis on inhibition of recombinant CYP3A4 activity by structurally diverse compounds using genetic algorithm combined partial least squares method (2001) (1)
- Hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) in the perfused rat liver. (1998) (1)
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS (1983) (1)
- PRODRUGS OF 6-THIOPURINES: ENHANCED DELIVERY THROUGH THE SKIN (1983) (1)
- Liposomal In vivo Gene Delivery (2008) (1)
- In silico prediction and control of ADME properties. (2003) (1)
- In Vivo Gene Transfer by Ligand-Modified Gene Carriers (2005) (1)
- In Vivo Disposition Characteristics of Plasmid DNA Complexed with Cationic Liposomes (2003) (1)
- Progress and Prospect in Development of Drug Delivery System. (1995) (1)
- Estimation of drug concentration profiles in skin based on a skin diffusion model. (1997) (1)
- Intravital imaging of live mice at cellular resolution (2016) (1)
- ANALYSIS OF ACTION MECHANISM OF PERCUTANEOUS PENETRATION ENHANCER BASED ON PHYSIOLOGICAL SKIN DIFFUSION MODEL (1992) (0)
- Development of Cell‐Selective Targeting Systems of NFϰB Decoy for Inflammation Therapy (2008) (0)
- DIFFERENTIAL ROLE OF SERUM MANNAN BINDING PROTEIN IN PHARMACOKINETICS OF MANNOSYLATED POLYMERIC AND PARTICULATE DRUG CARRIERS (2001) (0)
- Spatial and temporal control of drug delivery. Future perspectives of drug delivery research. (1995) (0)
- Development of Nucleic Acid Transfection Technology to the Kidney (2009) (0)
- EVALUATION OF ABSORPTIVE BARRIER TO PEPTIDES AND IMPROVEMENT OF MUCOSAL ABSORPTION OF PEPTIDES BY VARIOUS APPROACHES (1990) (0)
- EFFECT OF MANNOSE DENSITY ON MANNOSE RECEPTOR-MEDIATED CELLULAR UPTAKE OF MANNOSYLATED LIPOSOMES BY PRIMARY CULTURED ALVEOLAR MACROPHAGES (2006) (0)
- ENHANCED LYMPHATIC DELIVERY OF MIYOMYCIN C BY POLYMERIC MODIFICATION (1984) (0)
- Neutralized lipid envelope-type nanoparticle encapsulating pDNA as a liver-specific and long-lasting gene expression (2013) (0)
- doxorubicin n genetic engineering n intracellular drug delivery n nascent high-density lipoprotein n protein transduction domain n TAT peptide (2010) (0)
- Theoretical Design of Skin Penetration Enhancement Via Prodrug-Enhancer Combination Based on a Diffusion Model (1996) (0)
- 1A1-V04 Development of Implantable Drug Delivery Systems Using PDMS Pneumatic Balloons(MEMS and Nano-Technology) (2012) (0)
- Microsoft Word-83211850-file00 (2008) (0)
- CpG DNA delivery system for cancer immunotherapy (2002) (0)
- Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders (2009) (0)
- Development of in vivo gene delivery methods in mice using tissue suction devices for abdominal endoscopic gene therapy (2012) (0)
- Minocycline Hydrochloride Controlled-release Microsphere Preparation Process Optimization Based on the Robust Design Method. (2021) (0)
- Evaluation of Gene Expression In Vivo After Intravenous and Intraportal Administration of Lipoplexes (2005) (0)
- PHARMACOKINETIC ANALYSIS OF DRUG DISPOSITION AFTER INTRATUMORAL INJECTION IN TISSUE-ISOLATED TUMOR PERFUSION SYSTEM (1997) (0)
- THEORETICAL DESIGN OF OPTIMAL PRODRUG FOR SKIN PENETRATION ENHANCEMENT BASED ON A DIFFUSION MODEL (1996) (0)
- [Drug delivery system for optimizing therapeutic effects: recent trends in research]. (1998) (0)
- mannose receptors and mannan-binding protein In vivo recognition of mannosylated proteins by hepatic (2016) (0)
- Control of hepatic disposition of mannosylated liposomes by PEGylation: effect of the molecular weight of PEG and the density of PEG and mannose (2003) (0)
- BIOPHARMACEUTICAL STUDIES ON ANTITUMOR DRUG-INDUCED GASTROINTESTINAL DAMAGES (1987) (0)
- EVALUATION OF THE DELIVERY SYSTEMS FOR PROTEIN DRUGS WITH CHEMICAL MODIFICATION USING CELL CULTURE SYSTEMS (1995) (0)
- SIZE-DEPENDENT HEPATIC DISPOSITION OF POLYSTYRENE MICROSPHERES (1998) (0)
- STUDY ON THE ACTION OF PERCUTANEOUS PENETRATION ENHANCERS : EFFECT ON VARIOUS DRUGS WITH DIFFERENT PHYSICOCHEMICAL PROPERTIES (1989) (0)
- Title Tumor growth suppression by the combination of nanobubblesand ultrasound (2016) (0)
- A SIMPLE PDMS-BASED SUCTION DEVICE FOR STABILIZING IN VIVO REAL-TIME FLUORESCENCE IMAGING OF TRANSPLANTED CELLS IN LIVE ANIMALS (2011) (0)
- AAPS Connection (2009) (0)
- [Theory and methods of drug targeting]. (1989) (0)
- Development of the inclusive evaluation method for the percutaneous absorption III : Prediction of human dermal concentration of chemicals in various vehicles (2006) (0)
- AAPS Connection (2010) (0)
- Estimation of in vivo percutaneous absorption of emedastine from bile excretion data using a deconvolution method. (2005) (0)
- RELATIONSHIP BETWEEN PHYSICOCHEMICAL CHARACTERISITCS, DISTRIBUTION OF DNA-CATIONIC LIPOSOME COMPLEXES AND THEIR GENE EXPRESSION, AND APPLICATION TO GENE THERAPY (2000) (0)
- Inhibitory effect of superoxide dismutase derivatives modified with various sugar moieties on ischemia/reperfusion injury. (1993) (0)
- Effect of various vehicles on the ocular absorption of insulin in the albino rabbit. (1991) (0)
- Immunotherapy Against Peritoneal Dissemination by Immunostimulatory CpG DNA (2007) (0)
- Gene delivery to the lung (2008) (0)
- 2D- and 3D-QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells (2002) (0)
- Drug absorption from the gastrointestinal tract and immunity: the mechanism of the decreased absorption of salicylic acid during systemic anaphylaxis. II. (1984) (0)
- Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids) (2000) (0)
- Title Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF- κB signaling (2018) (0)
- Design and Evaluation of Monoclonal Antibody-Antitumor Agent Conjugate (1989) (0)
- Tissue-isolated Tumor Preparation Disposition Characteristics of Macromolecules in the Perfused (2006) (0)
- In Silico Prediction of Pharmacokinetics Properties (2006) (0)
- Cover Picture: Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and 19F Magnetic Resonance Imaging (ChemBioChem 10/2017) (2017) (0)
- Evaluation of the Immune Response After Administration of Plasmid DNA-Non-viral Vector Complexes (2005) (0)
- Ocular delivery of flurbiprofen from ophthalmic liposomes dispersed in thermosensitive gel (2000) (0)
- Effect of absorption promoters on nasal and pulmonary absorption of drugs with various molecular weight was examined in rats. (1991) (0)
- QUANTITATIVE ANALYSIS OF DRUG DISPOSITION : APPLICATION OF STATISTICAL MOMENT THEORY TO LOCAL PERFUSION SYSTEM (1986) (0)
- Control of biopharmaceutical properties of uricase by conjugation with dextran derivatives. (1989) (0)
- Development of delivery systems of DNA medicines and possible obstacles to be overcome. (1995) (0)
- PHARMACEUTICAL STUDIES ON LIPOSOMES : IMPROVEMENT OF ENTRAPPING EFFICIENCY FOR WATER SOLUBLE DRUGS BY FREEZING METHOD (1984) (0)
- CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis. (2022) (0)
- Pharmacokinetic Analysis of the in Vivo Disposition of Chemically Modified Proteins in Rats : Effect of Radiolabeling Method (1998) (0)
- A physiological role of interferon (IFN)-beta derived from tumor: tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-beta. (1997) (0)
- Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery (2006) (0)
- Comparison of polythylene glycol and dextran conjugation with protein drug. (1989) (0)
- Title Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling (2018) (0)
- Erratum to “Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells” [J. Control. Release 107(2005) 373–382] (2006) (0)
- The effect of the molecular weight of glycosylated proteins on their targeting efficiency to the liver. (1994) (0)
- Erratum: In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes (Journal of Drug Targeting (1995) vol. 3 (149-157)) (2003) (0)
- Contractile skeletal muscle microtissues in microchannel (2012) (0)
- Synthesis and Antitumor Activity of Macromolecular Derivatives of Mitomycin C (1989) (0)
- Disposition and gene expression of plasmid DNA complexed with cationic carriers (1996) (0)
- CELLULAR INTERACTION AND ANTITUMOR ACTIVITY OF MITOMYCIN C PRODRUGS (1985) (0)
- Interaction of drug carriers with blood components and their application to drug targeting (1999) (0)
- [Control of in vivo characteristics of gene and antisense DNA disposition]. (1994) (0)
- CELL-SPECIFIC TARGETING OF DRUGS BY RECEPTOR-MEDIATED ENDOCYTOSIS BASED ON SUGAR RECOGNITION SYSTEMS (1993) (0)
- Prediction of skin permeability of compounds from their molecular structure (2006) (0)
- Liver Cell-Selective Targeting Using Glycosylated Liposomes (1999) (0)
- [Opinion]Expectation for regulatory science (2014) (0)
- Gene delivery system for multidrug-resistance (2005) (0)
- Development of evaluation method for drug disposition in tumor using tissue-isolated tumor perfusion system. (1990) (0)
- Development and Therapeutic Application of Transposon‐Based Vectors (2010) (0)
- CONTROL OF IN VIVO FATE OF PROTEIN DRUGS USING CHEMICAL MODIFICATION WITH SUGARS (1991) (0)
- US 6 , 310 , 039 B 1 1 ANTINEOPLASTIC CONJUGATES OF TRANSFERRIN , ALBUMIN AND POLYETHYLENE GLYCOL (2017) (0)
- Lazar : An inductive database for the in silico prediction of carcinogenicity (2005) (0)
- Development of Delivery Systems for Antisense Oligonucleotides (1996) (0)
- DDS TECHNOLOGY REQUIRED FOR EFFECTIVE IN VIVO GENE TRANSFER (2001) (0)
- Biodistribution Characteristics of Surface Charge Improved Lysine Dendrimers after Intravenous Injection in Mice (2009) (0)
- Control of disposition characteristics of catalase by chemical modification (1996) (0)
- Real Time Imaging of Biological Phenomena with Super-duper Luminescent Proteins (2015) (0)
- 1 Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR 4 – NF-B signaling (2017) (0)
- Cellular interaction and in vitro antitumor activity of lipophilic mitomycin C prodrugs. (1987) (0)
- Tissue-specific in vivo gene transfer characteristics following direct injection of plasmid DNA (2003) (0)
- Fluorescence Real-time Imaging of Cell Dynamics in Tissue of a Living Mouse using Tissue Fixing Suction Device (2013) (0)
- Immunoconjugate of monoclonal antibody A7 and mitomycin C-dextran conjugate linked through thioether bond. (1991) (0)
- The application of the in-situ hyperthermia emission from acoustic nanodroplets for theranostic dual-imaging and antitumor modalities. (2020) (0)
- Title Photothermal ablation of tumor cells using a single-walledcarbon nanotube-peptide composite (2016) (0)
- 糖誘導体、またはその塩、セレクチン結合剤、糖結合体、粒子状キャリア、および輸送方法 (2015) (0)
- Evaluation of drug disposition in brain by moment analysis (II) (1990) (0)
- HEPATIC DISPOSITION CONTROL OF LIPOPHILIC DRUGS VIA LIPID CARRIER SYSYTEMS (1994) (0)
- Strictness and Transparency in Approval Process of Medical Products: Japanese Situation (2020) (0)
- Role of APSTJ in Advancement of Pharmaceutical Education (2008) (0)
- Biodistribution control of lipophilic drugs with lipid carrier system. (1995) (0)
- Targeting of e-selectin expressing human endothelial cells using liposomes with a Sialyl Lewis X ligand (2013) (0)
- Pharmacokinetic analysis of mannose receptor-mediated hepatic targeting of proteins: Capacity-limited hepatic uptake and saturable binding in plasma (1998) (0)
- Modeling and Prediction of Solvent Effect on Human Skin Permeability using Support Vector Regression and Random Forest (2015) (0)
- INTESTINAL ABSORPTION OF HAPTENS IN RATS IMMUNIZED WITH PROTEIN-HAPTEN CONJUGATE : COMPARISON OF SULFANILIC ACID WITH P-AMINOBENZOIC ACID (1990) (0)
- DEVELOPMENT OF HEPATOCYTE-SPECIFIC GENE DELIVERY SYSTEMS BASED ON PHARMACOKINETIC STUDIES (2000) (0)
- Pharmacokinetic analysis of123I-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation (1999) (0)
- The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice (2011) (0)
- Pharmaceutical Sciences in the Future: The Bridge Linking between Basic and Clinical Research. (2017) (0)
- Optimization of penetration enhancement based on action mechanism and site of enhancers. (1993) (0)
- Development of drug delivery systems for cancer chemotherapy and its implicated problem. (1992) (0)
- Pharmacokinetics of plasmid DNA-based non-viral gene medicine. (2005) (0)
- Development of monoclonal antibody-drug conjugate A7-MMC utilizing dextran as intermediate carrier (1988) (0)
- Uptake Characteristics of Anionized and Cationized Proteins in Brain Microvessel Endothelial Cells (1997) (0)
- Physicochemical and disposition characteristics of plasimid DNA complexed with cationic liposomes (1995) (0)
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