Mohamed Lamkanfi
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Computational Linguistics
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Machine Learning
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Computer Science
Mohamed Lamkanfi's Degrees
- PhD Computer Science University of California, Berkeley
- Masters Computer Science Stanford University
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(Suggest an Edit or Addition)Mohamed Lamkanfi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Non-canonical inflammasome activation targets caspase-11 (2011) (1951)
- Mechanisms and Functions of Inflammasomes (2014) (1775)
- Intracellular NOD-like receptors in host defense and disease. (2007) (996)
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. (2010) (837)
- Inflammasomes and their roles in health and disease. (2012) (774)
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome (2009) (696)
- The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. (2009) (684)
- Caspases in cell survival, proliferation and differentiation (2007) (591)
- Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. (2007) (559)
- Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella (2010) (509)
- Caspases in Cell Death, Inflammation, and Disease. (2019) (508)
- Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia (2010) (425)
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes (2014) (411)
- Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions (2008) (411)
- Manipulation of host cell death pathways during microbial infections. (2010) (396)
- Emerging inflammasome effector mechanisms (2011) (395)
- Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis (2019) (393)
- Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis (2014) (386)
- Inflammasomes: guardians of cytosolic sanctity (2009) (376)
- Alice in caspase land. A phylogenetic analysis of caspases from worm to man (2002) (369)
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. (2011) (341)
- IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation (2010) (339)
- NLRP6 Negatively Regulates Innate Immunity and Host Defense Against Bacterial Pathogens (2012) (335)
- Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019) (332)
- Pyroptosis (2016) (313)
- Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection (2013) (306)
- The mitochondrial serine protease HtrA2/Omi: an overview (2008) (295)
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes *S (2008) (289)
- Phosphorylation of NLRC4 is critical for inflammasome activation (2012) (269)
- Dietary modulation of the microbiome affects autoinflammatory disease (2014) (247)
- The Nlrp3 inflammasome: contributions to intestinal homeostasis. (2011) (228)
- Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens* (2012) (228)
- Caspase-7: a protease involved in apoptosis and inflammation. (2010) (223)
- Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens (2011) (220)
- Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping (2014) (206)
- Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1 (2009) (206)
- Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. (2015) (205)
- Caspase‐1 inflammasomes in infection and inflammation (2007) (204)
- Complementarity and redundancy of IL-22-producing innate lymphoid cells (2015) (198)
- Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture (2018) (196)
- NOD-like receptors and the innate immune system: coping with danger, damage and death. (2011) (182)
- Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation (2014) (181)
- The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection (2015) (174)
- RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3 (2013) (151)
- Caspase-1 Activates Nuclear Factor of the κ-Enhancer in B Cells Independently of Its Enzymatic Activity* (2004) (140)
- Regulation of the expression and processing of caspase-12 (2003) (138)
- Role of Inflammasomes in Host Defense against Citrobacter rodentium Infection* (2012) (137)
- Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome* (2009) (134)
- Caspase-12: an overview (2004) (134)
- Deregulated inflammasome signaling in disease (2011) (128)
- Nlrp6‐ and ASC‐Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition (2017) (127)
- TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation* (2011) (126)
- The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation1 (2007) (126)
- A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation (2018) (125)
- Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation (2016) (125)
- Proteome-wide Identification of HtrA2/Omi Substrates. (2007) (124)
- Nlrp3: an immune sensor of cellular stress and infection. (2010) (124)
- IL-33 raises alarm. (2009) (121)
- GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever (2018) (118)
- Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation (2014) (114)
- NOD‐like receptor (NLR) signaling beyond the inflammasome (2010) (111)
- HMGB1 release by inflammasomes (2011) (110)
- Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation (2015) (109)
- Critical role for inflammasome-independent IL-1β production in osteomyelitis (2013) (106)
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection (2013) (105)
- Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes (2010) (103)
- An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. (2015) (102)
- Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5 (2015) (98)
- INCA, a Novel Human Caspase Recruitment Domain Protein That Inhibits Interleukin-1β Generation* (2004) (98)
- Inflammasome-independent Role of Apoptosis-associated Speck-like Protein Containing a CARD (ASC) in T Cell Priming Is Critical for Collagen-induced Arthritis* (2010) (96)
- Therapeutic modulation of inflammasome pathways (2020) (91)
- Inflammatory caspases: targets for novel therapies. (2007) (89)
- Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection (2014) (82)
- Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 (2017) (82)
- Inflammatory caspases: key regulators of inflammation and cell death (2015) (75)
- Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis. (2019) (73)
- A Novel Caspase-2 Complex Containing TRAF2 and RIP1* (2005) (73)
- A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins. (2007) (68)
- The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization (2011) (66)
- MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition (2019) (66)
- Inflammasomes in respiratory disease: from bench to bedside. (2014) (65)
- Caspases leave the beaten track: caspase-mediated activation of NF-κB (2006) (64)
- The emerging roles of inflammasome‐dependent cytokines in cancer development (2019) (63)
- Airway structural cells regulate TLR5-mediated mucosal adjuvant activity (2013) (62)
- Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection (2019) (60)
- Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. (2009) (58)
- Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection (2016) (58)
- Escherichia coli α-Hemolysin Counteracts the Anti-Virulence Innate Immune Response Triggered by the Rho GTPase Activating Toxin CNF1 during Bacteremia (2015) (51)
- Inflammasomes as polyvalent cell death platforms (2016) (50)
- NOD‐like receptors interfacing the immune and reproductive systems (2014) (50)
- Regulation of immune pathways by the NOD-like receptor NLRC5. (2012) (49)
- Caspase-containing complexes in the regulation of cell death and inflammation (2006) (48)
- Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis (2014) (48)
- Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease. (2019) (47)
- Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulphate-induced colitis (2014) (46)
- Cutting Edge: SHARPIN Is Required for Optimal NLRP3 Inflammasome Activation (2015) (45)
- Inflammasomes: Caspase-1-Activating Platforms with Critical Roles in Host Defense (2010) (42)
- Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes (2015) (41)
- Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis (2018) (41)
- The Inflammasomes (2009) (41)
- Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent Nuclear Factor κB Signaling* (2011) (40)
- DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages (2019) (39)
- An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages (2020) (37)
- In Retrospect: The inflammasome turns 15 (2017) (36)
- Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections (2017) (36)
- Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities (2020) (35)
- Does caspase-12 suppress inflammasome activation? (2016) (34)
- The caspase family (2003) (32)
- NLRP2 controls age-associated maternal fertility (2016) (31)
- The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal (2010) (31)
- IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D (2020) (29)
- Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever (2020) (27)
- The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling* (2013) (26)
- A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation (2019) (26)
- CARD‐ and pyrin‐only proteins regulating inflammasome activation and immunity (2015) (24)
- Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles (2019) (24)
- Addendum: Defective Dock2 expression in a subset of ASC-deficient mouse lines (2012) (23)
- Protective and detrimental roles of inflammasomes in disease (2015) (22)
- Monitoring of Fluconazole and Caspofungin Activity against In Vivo Candida glabrata Biofilms by Bioluminescence Imaging (2018) (21)
- Escherichia coli RhoGTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21 activated kinases-1/2 during bacteremia in mice (2021) (20)
- Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies (2018) (19)
- The inflammasome: A remote control for metabolic syndrome (2012) (19)
- K⁺ drops tilt the NLRP3 inflammasome. (2013) (19)
- Gold nanodome SERS platform for label-free detection of protease activity. (2017) (19)
- Familial Mediterranean Fever and COVID-19: Friends or Foes? (2020) (18)
- The NEK-sus of the NLRP3 inflammasome (2016) (18)
- General Strategies in Inflammasome Biology. (2016) (18)
- Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax (2019) (17)
- Inflammasomes and Intestinal Tumorigenesis. (2011) (16)
- Defining the Impact of Host Genotypes on Microbiota Composition Requires Meticulous Control of Experimental Variables. (2018) (15)
- A new lead to NLRP3 inhibition (2017) (15)
- MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition (2019) (12)
- Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria (2014) (11)
- GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis (2022) (10)
- Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22 (2016) (9)
- Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax (2022) (8)
- The human inflammasomes. (2022) (8)
- Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells. (2021) (8)
- Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface. (2020) (6)
- El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes (2019) (6)
- Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa (2022) (6)
- Innate Immune Pathways in Host Defense (2012) (5)
- Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition (2019) (4)
- Bacterial and Viral Pathogens Modulation of Inflammasome Pathways by (2012) (4)
- Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection (2022) (4)
- The Nlrp3 inflammasome in IBD and colorectal tumorigenesis (2011) (4)
- Caspase-1 Activation Growth Independently of pneumophila Legionella Naip 5 / Birc 1 e Restricts The Nod-Like Receptor Family Member (2007) (3)
- Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity (2020) (2)
- Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation (2019) (2)
- Immunology: Gut sensor halts viral attack (2017) (2)
- Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited. (2017) (2)
- Pseudomonas aeruginosa infection reveals a Caspase-1-dependent neutrophil pyroptosis pathway that restrains damaging Histone release (2021) (1)
- Inflammasomes as polyvalent cell death platforms (2016) (1)
- Alarmin HMGB 1 in Endotoxemia Inflammasome-Dependent Release of the Dixit (2010) (1)
- How to dodge pyroptosis: lessons from Shigella flexneri (2021) (1)
- Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection (2022) (1)
- Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes (2015) (0)
- Abstract A083: Inflammasome-independent IL-1β release by myeloid cells promotes vessel destabilization and immune suppression in the tumor microenvironment (2019) (0)
- Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture (2018) (0)
- Inflammasome-Dependent Release of the Dixit (2010) (0)
- A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation (2018) (0)
- This information is current as Colorectal Tumor Formation Inflammasome Confers Protection against IL-18 Production Downstream of the Nlrp 3 (2010) (0)
- SP0160 Protective and Detrimental Roles of Inflammasomes (2016) (0)
- Complex regulation of alarmins S100A8/A9 and secretion via Gasdermin-D pores exacerbates autoinflammation in Familial Mediterranean Fever. (2023) (0)
- P776 Dysbiosis in Nlrp6/Asc-deficient mice does not result from inflammasome deficiency. (2017) (0)
- Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis (2019) (0)
- NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes (2016) (0)
- Activation Extracellular Signal-regulated Kinase via Listeria monocytogenes Autophagy of TLR 2 and RIP 2 Pathways Mediate Immunology : (2011) (0)
- E11 Multiple inflammasomes direct innate immune responses against Salmonella (2010) (0)
- This information is current as and Nlrc 4 Inflammasomes Nlrp 3 Poly ( ADP-Ribose ) Polymerase 1 by the Cutting Edge : Proteolytic Inactivation of Lamkanfi and Thirumala (2010) (0)
- Protective and detrimental roles of inflammasomes in disease (2015) (0)
- Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax (2019) (0)
- Colorectal Tumor Formation Inflammasome Confers Protection against IL-18 Production Downstream of the Nlrp3 (2010) (0)
- Comment On: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3. (2022) (0)
- Abstracts of the 12th Congress of ECCO – European Crohn’s and Colitis Organisation (2019) (0)
- Tuberculosis: The tug of war between pathogen and inflammasome (2023) (0)
- Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis (2018) (0)
- Towards mulitplexed SERS-based on-chip detection on protease activity (2018) (0)
- Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities (2020) (0)
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What Schools Are Affiliated With Mohamed Lamkanfi?
Mohamed Lamkanfi is affiliated with the following schools:
