Mónica Bettencourt-Dias
Portuguese biochemist and cellular biologist, (1974– ), Portugal
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Biology
Mónica Bettencourt-Dias's Degrees
- Bachelors Biochemistry University of Lisbon
Why Is Mónica Bettencourt-Dias Influential?
(Suggest an Edit or Addition)Areas of Specialization: Molecular Biology
Monica Bettencourt-Dias is the Director of Instituto Gulbenkian de Ciência. A biochemist and cellular biologist, she is also the head of the Cell Cycle Regulation research group. She earned her undergraduate degree in biochemistry from the University of Lisbon, and graduated from University College London with a doctorate in biochemistry and molecular biology. She split her postdoctoral time between the University of Cambridge and Birkbeck, University of London, where she researched kinases and scientific communication. She earned a Diploma in Science Communication from Birkbeck College in 2004, which arose from her work on improving how scientists communicate with the public.
Her laboratory work has focused on complex subcellular structure and how they change during disease, development, and evolution, using complex cytoskeletal assemblies for study. For her research efforts, Bettencourt-Dias has won numerous awards, including the Eppendorf Young European Investigator Award, the Pfizer Award for Basic Research, and the Keith Porter Prize from the American Society for Cell Biology.
She was named a European Molecular Biology Organization Young Investigator Fellow in 2009 and became a full member of that organization in 2015.
Bettencourt-Dias current research projects include studies of spatial control of centriole biogenesis, causes, and consequences of centriole deregulation in cancer, the evolution of microtubule-organizing centers, and mechanisms of cilia diversification.
Featured in Top Influential Biologists Today and Top Women in STEM
According to Wikipedia, Mónica Bettencourt-Dias is a Portuguese biochemist and cellular biologist, who is the head of the Cell Cycle Regulation research group at the Instituto Gulbenkian de Ciência. Her research involves cell cycle regulation, for which she has been recognized as the recipient of the Pfizer Award for Basic Research, the Keith Porter Prize from the American Society for Cell Biology and the Eppendorf Young European Investigator Award. She was also selected as a 2009 European Molecular Biology Organization Young Investigator Fellow and inducted as a member of the EMBO in 2015. Mónica Bettencourt-Dias was appointed Director of Instituto Gulbenkian de Ciência in November, 2017.
Mónica Bettencourt-Dias's Published Works
Published Works
- SAK/PLK4 Is Required for Centriole Duplication and Flagella Development (2005) (590)
- Centrosome biogenesis and function: centrosomics brings new understanding (2007) (557)
- Genome-wide survey of protein kinases required for cell cycle progression (2004) (359)
- Polo-like kinases: structural variations lead to multiple functions (2014) (356)
- Centrosomes and cilia in human disease. (2011) (334)
- Tracing the origins of centrioles, cilia, and flagella (2011) (313)
- Asterless is a scaffold for the onset of centriole assembly (2010) (288)
- Revisiting the Role of the Mother Centriole in Centriole Biogenesis (2007) (280)
- The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4 (2009) (244)
- Stepwise evolution of the centriole-assembly pathway (2010) (218)
- DSAS-6 Organizes a Tube-like Centriole Precursor, and Its Absence Suggests Modularity in Centriole Assembly (2007) (197)
- Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes (2003) (140)
- Deconstructing the centriole: structure and number control. (2012) (126)
- Centrioles: active players or passengers during mitosis? (2010) (103)
- Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number (2013) (100)
- BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair. (2012) (93)
- Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation (2018) (84)
- A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster (2016) (81)
- From centriole biogenesis to cellular function: Centrioles are essential for cell division at critical developmental stages (2008) (79)
- Building the right centriole for each cell type (2018) (73)
- Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution. (2014) (72)
- PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space. (2015) (67)
- CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis (2016) (65)
- Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity (2018) (54)
- Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis (2018) (49)
- Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila (2015) (48)
- Tracing the origins of centrioles, cilia, and flagella (2011) (47)
- PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation (2018) (46)
- Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis (2012) (44)
- From Zero to Many: Control of Centriole Number in Development and Disease (2009) (41)
- Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes (2016) (37)
- Maintaining centrosomes and cilia (2017) (37)
- Centrosome Remodelling in Evolution (2018) (36)
- RNAi in Drosophila S2 cells as a tool for studying cell cycle progression. (2009) (34)
- Double life of centrioles: CP110 in the spotlight. (2008) (34)
- Drosophilamelanogaster as a model for basal body research (2016) (33)
- Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome (2019) (30)
- SnapShot: Centriole Biogenesis (2009) (23)
- γ-Tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells (2009) (22)
- Q&A: Who needs a centrosome? (2013) (21)
- Noncanonical Biogenesis of Centrioles and Basal Bodies. (2017) (17)
- Pericentrin-mediated SAS-6 recruitment promotes centriole assembly (2019) (17)
- Polo boxes come out of the crypt: a new view of PLK function and evolution. (2012) (17)
- Evolution of centriole assembly (2020) (15)
- Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia (2020) (12)
- CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett’s Esophagus Malignant Progression (2016) (12)
- Plk4 triggers autonomous de novo centriole biogenesis and maturation (2020) (12)
- RNAi in Drosophila Cell Cultures (2004) (10)
- Biophysical and Quantitative Principles of Centrosome Biogenesis and Structure. (2021) (8)
- Methods to Study Centrosomes and Cilia in Drosophila. (2016) (6)
- Centrosomes and cilia in health and disease Mechanisms of Biogenesis and Function (2012) (6)
- Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1 (2021) (5)
- The 3D architecture and molecular foundations of de novo centriole assembly via bicentrioles (2020) (5)
- Pericentriolar material (2020) (4)
- Microscopy methods for the study of centriole biogenesis and function in Drosophila. (2010) (4)
- Strategies to promote science communication: organisation and evaluation of a workshop to improve the communication between Portuguese researchers, the media and the public (2012) (4)
- A structural road map to unveil basal body composition and assembly (2012) (3)
- Patterns of selection against centrosome amplification in human cell lines (2020) (3)
- PLK4 is a microtubule-associated protein that self assembles promoting de novo MTOC formation (2018) (2)
- Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation (2018) (2)
- An ancestral role of pericentrin in centriole formation through SAS-6 recruitment (2018) (2)
- The architectural landscape of diverse ciliary functions (2015) (1)
- Centrosome Assembly: Reconstructing the Core Cartwheel Structure In Vitro (2017) (1)
- Assembling complex biological structures (2008) (1)
- Author response: Pericentrin-mediated SAS-6 recruitment promotes centriole assembly (2019) (1)
- Faculty Opinions recommendation of Centriole age underlies asynchronous primary cilium growth in mammalian cells. (2009) (1)
- Training Scientists in Communication Skills (2007) (1)
- The Cell Cycle, Cytoskeleton and Cancer (2019) (1)
- Faculty Opinions recommendation of The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation. (2014) (0)
- A Conversation with Mónica Bettencourt-Dias. (2017) (0)
- A first-takes-all model of centriole copy number control based on cartwheel elongation (2020) (0)
- Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype (2022) (0)
- Cell cycle re-entry and plasticity in the adult newt cardiomyocyte (1999) (0)
- Fission yeast as a test tube to study centrosome evolution and biogenesis (2016) (0)
- Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer: PS155. (2017) (0)
- McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation (2022) (0)
- Q&A: Who needs a centrosome? (2013) (0)
- Mónica Bettencourt-Dias: centered on centrioles. Interview by Ben Short. (2010) (0)
- Mónica Bettencourt-Dias (2017) (0)
- Winner of the Eppendorf Young Investigator Award 2007 (2007) (0)
- IFT88 transports Gucy2d, a guanylyl cyclase, to maintain sensory cilia function in Drosophila (2020) (0)
- Faculty Opinions recommendation of An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry. (2015) (0)
- Full Title: Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution Short Title: Secrets of centriole and cilia assembly Authors: (2017) (0)
- Faculty Opinions recommendation of A mechanism for the evolution of phosphorylation sites. (2012) (0)
- High prevalence and dependence of centrosome clustering in mesenchymal tumors and leukemia (2023) (0)
- Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity (2018) (0)
- 1188 WWTR1 and CYR61 Are Early Prognostic Markers of Barrett's Esophagus Malignant Progression (2012) (0)
- Studying Centriole Duplication and Elongation in Human Cells. (2020) (0)
- From centrosomal microtubule anchoring and organization to basal body positioning: TBCCD1 an elusive protein (2019) (0)
- Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase (2022) (0)
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