Monica Justice
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American–Canadian developmental geneticist
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(Suggest an Edit or Addition)According to Wikipedia, Monica J. Justice is an American–Canadian developmental geneticist. She is the Canada Research Chair in Mammalian Molecular Genetics at the University of Toronto and Program Head of Genetics and Genome Biology at SickKids Hospital.
Monica Justice's Published Works
Published Works
- High-throughput discovery of novel developmental phenotypes (2016) (824)
- A twist code determines the onset of osteoblast differentiation. (2004) (670)
- Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail (2001) (492)
- A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. (1989) (410)
- Gene defect in ectodermal dysplasia implicates a death domain adapter in development (2001) (367)
- Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice (2004) (359)
- The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins (1996) (326)
- Functional genetic analysis of mouse chromosome 11 (2003) (209)
- Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis (2002) (199)
- Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome (2008) (191)
- Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium (2017) (190)
- Identification of the murine beige gene by YAC complementation and positional cloning (1996) (190)
- Using the mouse to model human disease: increasing validity and reproducibility (2016) (186)
- Preclinical research in Rett syndrome: setting the foundation for translational success (2012) (180)
- Prevalence of sexual dimorphism in mammalian phenotypic traits (2017) (177)
- The mutagenic action of N-ethyl-N-nitrosourea in the mouse (2000) (158)
- Effects of ENU dosage on mouse strains (2000) (152)
- Overexpression of Eg5 causes genomic instability and tumor formation in mice. (2007) (139)
- Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. (1990) (139)
- Functional Annotation of Mouse Genome Sequences (2001) (136)
- The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. (2004) (113)
- The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice (2001) (110)
- A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome (2013) (110)
- Mutation discovery in mice by whole exome sequencing (2011) (109)
- Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity (2006) (108)
- UBE2O remodels the proteome during terminal erythroid differentiation (2017) (107)
- Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12. (1994) (107)
- Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. (2007) (105)
- COP9 Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse Embryonic Epiblast (2003) (105)
- A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction (2017) (104)
- Capitalizing on large-scale mouse mutagenesis screens (2000) (104)
- Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. (2005) (104)
- A suppressor screen in Mecp 2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) (100)
- Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome. (1997) (92)
- Quaking is essential for blood vessel development (2002) (91)
- Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. (2004) (88)
- Rett syndrome: a neurological disorder with metabolic components (2018) (88)
- A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross. (1990) (87)
- Three ENU-induced alleles of the murine quaking locus are recessive embryonic lethal mutations. (1988) (83)
- Host sanctions and the legume – rhizobium mutualism (2014) (82)
- Implementing Large-Scale ENU Mutagenesis Screens in North America (2004) (82)
- Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs‐large tumor suppressor (2006) (78)
- Strain Background Influences Neurotoxicity and Behavioral Abnormalities in Mice Expressing the Tetracycline Transactivator (2012) (78)
- MEIG1 is essential for spermiogenesis in mice (2009) (74)
- Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase (2010) (72)
- Optimal N‐Ethyl‐N‐nitrosourea (ENU) doses for inbred mouse strains (2000) (71)
- A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. (2005) (71)
- The murine Il-6 gene maps to the proximal region of chromosome 5. (1989) (66)
- Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening (2013) (65)
- An Allelic Series of Mice Reveals a Role for RERE in the Development of Multiple Organs Affected in Chromosome 1p36 Deletions (2013) (65)
- Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene. (1999) (65)
- A molecular genetic linkage map of mouse chromosome 2. (1990) (64)
- MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex (2016) (60)
- Technical approaches for mouse models of human disease (2011) (58)
- Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemia (1999) (58)
- Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors (2011) (56)
- An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis. (1998) (54)
- Genetic profile of insertion mutations in mouse leukemias and lymphomas. (2000) (54)
- A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. (1992) (50)
- Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas (1994) (50)
- Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance (2011) (50)
- Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping. (2001) (50)
- The ataxia3 Mutation in the N-Terminal Cytoplasmic Domain of Sodium Channel Nav1.6 Disrupts Intracellular Trafficking (2009) (50)
- A resource of targeted mutant mouse lines for 5,061 genes (2019) (48)
- The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells (2003) (48)
- Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner (2007) (47)
- Functional genomics in the post-genome era. (1998) (47)
- Discovery of Candidate Disease Genes in ENU–Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin (2009) (47)
- A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci. (1990) (46)
- Induction of new mutations in a mouse t-haplotype using ethylnitrosourea mutagenesis. (1986) (46)
- Optical Coherence Tomography for live imaging of mammalian development. (2011) (46)
- Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains (2003) (45)
- A role for metabolism in Rett syndrome pathogenesis (2013) (45)
- Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome. (2004) (44)
- Checks and balancers: balancer chromosomes to facilitate genome annotation. (2004) (44)
- Complementation of the beige mutation in cultured cells by episomally replicating murine yeast artificial chromosomes. (1996) (44)
- Mutation in Archain 1, a Subunit of COPI Coatomer Complex, Causes Diluted Coat Color and Purkinje Cell Degeneration (2010) (42)
- Treating Rett syndrome: from mouse models to human therapies (2019) (41)
- TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. (2013) (41)
- The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis. (2007) (40)
- Sequence, molecular properties, and chromosomal mapping of mouse lumican. (1995) (40)
- Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina. (2001) (39)
- Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. (2013) (39)
- Mutation of l7Rn3 Shows That Odz4 Is Required for Mouse Gastrulation (2005) (38)
- Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos (2002) (37)
- A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination (2005) (36)
- Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia (2005) (36)
- PCR amplification and analysis of simple sequence length polymorphisms in mouse DNA using a single microchip device. (2000) (36)
- An interspecific backcross linkage map of mouse chromosome 8. (1990) (36)
- Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway. (2014) (36)
- The Zinc Finger SET Domain Gene Prdm14 Is Overexpressed in Lymphoblastic Lymphomas with Retroviral Insertions at Evi32 (2008) (36)
- Novel lethal mouse mutants produced in balancer chromosome screens. (2006) (33)
- Mouse as the measure of man? (2000) (33)
- Visceral endoderm function is regulated by quaking and required for vascular development (2006) (32)
- Mouse mutagenesis with the chemical supermutagen ENU. (2010) (31)
- Identification of genes required for eye development by high-throughput screening of mouse knockouts (2018) (30)
- The neurological mutant quakingviable is Parkin deficient (2004) (30)
- Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. (2008) (30)
- Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes (2017) (29)
- Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models (2011) (29)
- Regional Variation in the Density of Essential Genes in Mice (2007) (27)
- Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. (2013) (26)
- Comparative Analyses of Lung Transcriptomes in Patients with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins and in Foxf1 Heterozygous Knockout Mice (2014) (25)
- Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea (1999) (25)
- A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL) (2013) (24)
- Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome 13 linked to beige (bg) and identifies a new region of homology between mouse and human chromosomes. (1991) (24)
- Recombinant inbred mouse strains: models for disease study. (1992) (24)
- Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule Assembly and Sperm Tail Function1 (2004) (23)
- Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice. (2002) (22)
- A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene (2011) (22)
- Point mutations in the melanocortin-4 receptor cause variable obesity in mice (2006) (22)
- Mouse Tenm4 is required for mesoderm induction (2013) (21)
- From gene to treatment: supporting rare disease translational research through model systems (2019) (21)
- Genetic analysis of mouse t haplotypes using mutations induced by ethylnitrosourea mutagenesis: the order of T and qk is inverted in t mutants. (1988) (20)
- A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines (2009) (20)
- Mouse Mutagenesis Using N-Ethyl-N-Nitrosourea (ENU). (2008) (19)
- Craniofacial, skeletal, and cardiac defects associated with altered embryonic murine Zic3 expression following targeted insertion of a PGK-NEO cassette. (2007) (19)
- Comparative mapping in the beige-satin region of mouse chromosome 13. (1997) (18)
- Removing the cloak of invisibility: phenotyping the mouse (2008) (18)
- Mouse alleles: if you've seen one, you haven't seen them all. (1998) (18)
- Chromosome mapping of the murine syndecan gene. (1991) (16)
- Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression (2016) (16)
- Novel Frem1-Related Mouse Phenotypes and Evidence of Genetic Interactions with Gata4 and Slit3 (2013) (15)
- The role of quaking in mammalian embryonic development. (2010) (15)
- Cancer biology: Sleeping Beauty awakens (2005) (14)
- Genome-wide identification of mouse congenital heart disease loci. (2010) (14)
- MeCP 2 co-ordinates liver lipid metabolism with the NCoR 1 / HDAC 3 corepressor complex (2016) (14)
- ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development (2012) (13)
- Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma (2007) (13)
- Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology (2020) (13)
- CyTOF: An Emerging Technology for Single‐Cell Proteomics in the Mouse (2021) (13)
- Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis (2000) (12)
- Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility. (2002) (12)
- Rapid and Integrative Discovery of Retina Regulatory Molecules. (2018) (11)
- Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL (2012) (10)
- Defining the breakpoints of the quakingviable mouse mutation reveals a duplication from a Parkin intron (2005) (10)
- S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky. (1993) (10)
- Developmental eye and neural tube defects in the eye blebs mouse (2000) (9)
- ENU-induced allele of brachyury (Tkt1) exhibits a developmental lethal phenotype similar to the original brachyury (T) mutation. (1990) (7)
- A Point Mutation in the Gene for Asparagine-Linked Glycosylation 10B (Alg10b) Causes Nonsyndromic Hearing Impairment in Mice (Mus musculus) (2013) (7)
- Comparative physical maps of the human and mouse Meckel syndrome critical regions (2004) (7)
- Identification and characterization of a novel murine allele of Tmprss6 (2013) (6)
- Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. (2002) (6)
- Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening (2013) (6)
- Mouse chromosome 13 (1996) (6)
- Corrigendum: High-throughput discovery of novel developmental phenotypes (2017) (6)
- PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL (2016) (6)
- Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14. (2019) (6)
- Mouse Chromosome 13 (2004) (6)
- Bridging the gap between basic and applied biology: towards preclinical translation (2013) (6)
- Erratum: Functional genomics in the post-genome era (Mutation Research 400 (1998) (3-14) PII: 2002751098000232) (1998) (5)
- hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. (2008) (5)
- A mouse chromosome 19 genetic map including the Lvis1 viral insertion site. (1999) (4)
- From the Atomic Age to The Genome Project (2004) (4)
- Failure to identify modifiers of NEBULIN-related nemaline myopathy in two pre-clinical models of the disease (2019) (4)
- The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice (2019) (4)
- Model systems inform rare disease diagnosis, therapeutic discovery and pre-clinical efficacy. (2019) (4)
- Deficiency of FRAS 1-related extracellular matrix 1 ( FREM 1 ) causes congenital diaphragmatic hernia in humans and mice (2013) (3)
- Chromosome Engineering and ENU Mutagenesis: Their Use for Defining Gene Function (2003) (3)
- A comparative transcript map and candidates for mutant phenotypes in the Tyrp1 (brown) deletion complex homologous to human 9p21-23 (2000) (3)
- Tissue‐Specific Regulation of Oncogene Expression Using Cre‐Inducible ROSA26 Knock‐In Transgenic Mice (2015) (3)
- Mouse chromosome 13 (2004) (3)
- Location of the 9257 and ataxia mutations on mouse Chromosome 18 (1996) (3)
- Keratocan (Kera), a corneal keratan sulfate proteoglycan, maps to the distal end of mouse chromosome 10. (1998) (3)
- From blood development to disease: a paradigm for clinical translation. (2020) (3)
- Evaluation of Rett Syndrome Symptom Improvement by Metabolic Modulators in Mecp2‐Mutant Mice (2013) (3)
- Mouse chromosome 10 (2004) (3)
- From blood development to disease: a paradigm for clinical translation (2019) (2)
- Pten, a candidate tumor suppressor gene, maps to mouse Chromosome 19 (2009) (2)
- Corrigendum to Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway [Human molecular genetics 23, 7, (2013) 1687-1699] DOI: 10.1093/hmg/ddt558 (2014) (2)
- A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice. (2013) (2)
- Mouse Tenm4 is required for mesoderm induction (2013) (1)
- Meeting report: 11th international mouse genome conference (1998) (1)
- A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia (2021) (1)
- Of Mice and Men, and Medicine: an interview with Monica Justice (2013) (1)
- Treating Rett syndrome: from mouse models to human therapies (2019) (1)
- Mouse chromosome 13 (2004) (1)
- Suppressor mutations in Mecp2-null mice reveal that the DNA damage response is key to Rett syndrome pathology (2019) (1)
- Current Protocols in Mouse Biology (2011) (1)
- Aberrant lung lipids cause respiratory impairment in a Mecp2-deficient mouse model of Rett syndrome (2021) (1)
- Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts (2019) (1)
- Identification ofEvi-3, aNovelCommonSite ofRetroviral Integration inMouseAKXD B-Cell Lymphomas (1994) (1)
- Genetic screens in mice for androgen disorders (2003) (1)
- Differential requirement of ZIC3 function in cardiac development and X-linked heterotaxy (2011) (0)
- USING MOUSE MUTAGENESIS TO MODEL HUMAN DISEASE AND DEFINE MAMMALIAN GENE FUNCTION: 280 (2004) (0)
- Identification of genes required for eye development by high-throughput screening of mouse knockouts (2018) (0)
- QUAKING REGULATION OF VISCERAL ENDODERM FUNCTION IS REQUIRED FOR VASCULAR REMODELING AND RETINOIC ACID-MEDIATED CONTROL OF ENDOTHELIAL CELL PROLIFERATION (2004) (0)
- Referees for volume 30 (1992) (0)
- Referees for volume 30 (2004) (0)
- Faculty Opinions recommendation of Genomic copy number and expression variation within the C57BL/6J inbred mouse strain. (2008) (0)
- Developmental disorders Journal Meeting: a collaboration between Development and Disease Models & Mechanisms. (2021) (0)
- Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 13. (1993) (0)
- Faculty Opinions recommendation of Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. (2008) (0)
- The guarantors of this manuscript confirm that all persons designated as authors qualify for authorship, and that each author has participated sufficiently in the work to take public responsibility for appropriate portions of the content. (2012) (0)
- Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts (2019) (0)
- FREM1 deficiency causes lung lobulation defects in mice. (2013) (0)
- 18th International Mouse Genome Conference (2005) (0)
- The Functional Genomics Initiative at Oak Ridge National Laboratory (1997) (0)
- Mouse N-ethyl-N-nitrosourea (ENU) Mutagenesis (2006) (0)
- A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects (2023) (0)
- PROTEOSTASIS UBE 2 O remodels the proteome during terminal erythroid differentiation (2017) (0)
- Rsp1 Is Indispensable for mRNA Stability during Erythroid Terminal Differentiation (2008) (0)
- for mouse gastrulation (2004) (0)
- Faculty Opinions recommendation of A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (2009) (0)
- DMM Prize 2018 winner: Wenqing Zhou (2019) (0)
- NICHD SIXTH STRUCTURAL BIRTH DEFECTS (2008) (0)
- Encyclopedia of the mouse genome V. Mouse chromosome 13. (1996) (0)
- Faculty Opinions recommendation of A -defensin mutation causes black coat color in domestic dogs. (2008) (0)
- Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. (2020) (0)
- 17th International Mouse Genome Conference. (2004) (0)
- Inflammatory Disease and Abortive Platelet Shedding Caused by a Mutation in a Pivotal Regulator of Actin Dynamics in the redears Mouse. (2004) (0)
- Faculty Opinions recommendation of Interchromosomal interactions and olfactory receptor choice. (2007) (0)
- From its roots come branches and growth for Disease Models & Mechanisms (2021) (0)
- A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction (2017) (0)
- Integrative and rapid discovery of retinal regulatory molecules (2018) (0)
- ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development (2012) (0)
- Mutagenesis of the Mouse Genome (2004) (0)
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