Mortimer Poncz
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Mortimer Ponczphilosophy Degrees
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Mortimer Ponczbiology Degrees
Biology
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Molecular Biology
#1996
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Philosophy Biology
Mortimer Poncz's Degrees
- PhD Molecular Biology University of California, San Francisco
- Doctorate Medicine Stanford University
Why Is Mortimer Poncz Influential?
(Suggest an Edit or Addition)Mortimer Poncz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia (1999) (1053)
- Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. (1998) (628)
- Construction of human gene libraries from small amounts of peripheral blood: analysis of beta-like globin genes. (1982) (595)
- Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1 (2000) (503)
- Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. (1987) (368)
- Megakaryocytes regulate hematopoietic stem cell quiescence via Cxcl4 secretion (2013) (335)
- Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. (1997) (325)
- Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV (2003) (323)
- Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. (2005) (247)
- Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. (2006) (229)
- Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. (1996) (226)
- Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. (2000) (201)
- The genomic organization of platelet glycoprotein IIIa. (1990) (197)
- "Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method. (1982) (192)
- Organization of the gene for platelet glycoprotein IIb. (1990) (190)
- Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. (2001) (190)
- Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. (1995) (189)
- Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters (2003) (179)
- Control of megakaryocyte‐specific gene expression by GATA‐1 and FOG‐1: role of Ets transcription factors (2002) (171)
- Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. (2000) (165)
- Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. (1987) (161)
- CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. (2010) (158)
- Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. (2003) (156)
- NuRD mediates activating and repressive functions of GATA‐1 and FOG‐1 during blood development (2010) (154)
- Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. (2004) (145)
- Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. (2000) (143)
- Megakaryocyte precursors, megakaryocytes and platelets express the HIV co‐receptor CXCR4 on their surface: determination of response to stromal‐derived factor‐1 by megakaryocytes and platelets (1999) (143)
- Megakaryocyte biology and related disorders. (2005) (141)
- Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. (2010) (136)
- Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. (2010) (133)
- Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells* (2003) (130)
- Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. (2000) (126)
- Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. (2007) (125)
- Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. (1997) (125)
- The relative role of PLCbeta and PI3Kgamma in platelet activation. (2005) (124)
- Chemokine regulation of human megakaryocytopoiesis. (1995) (123)
- Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (1990) (120)
- Infusion of mature megakaryocytes into mice yields functional platelets. (2010) (118)
- Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. (2000) (118)
- Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. (2002) (113)
- Determinants of PF4/heparin immunogenicity. (2007) (112)
- Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. (1987) (111)
- Molecular Basis and Characterization of the Hyperinsulinism/Hyperammonemia Syndrome Predominance of Mutations in Exons 11 and 12 of the Glutamate Dehydrogenase Gene (2000) (111)
- Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. (1988) (109)
- Acute chest syndrome in sickle cell disease: etiology and clinical correlates. (1985) (108)
- Receptor and G protein-mediated responses to thrombin in HEL cells. (1991) (106)
- A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. (1991) (101)
- Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine (2007) (100)
- Neutrophil accumulation and NET release contribute to thrombosis in HIT. (2018) (99)
- Nucleotide sequence analysis of the delta beta-globin gene region in humans. (1983) (95)
- Rapid detection of the ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED) (1996) (94)
- Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. (2013) (93)
- An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. (1996) (93)
- Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. (1994) (93)
- Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. (2002) (93)
- Challenges and promises for the development of donor-independent platelet transfusions. (2013) (92)
- Atomic description of the immune complex involved in heparin-induced thrombocytopenia (2015) (91)
- Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. (2010) (91)
- Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. (2007) (90)
- Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. (2016) (90)
- Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. (2005) (90)
- Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. (2002) (85)
- Towards a standardization of the murine tail bleeding model (2010) (84)
- Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. (2014) (83)
- beta-Thalassemia in a Kurdish Jew. Single base changes in the T-A-T-A box. (1982) (81)
- Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. (1990) (80)
- Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia (1998) (80)
- The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions (1984) (79)
- Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. (2008) (78)
- Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. (2012) (75)
- The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. (2011) (75)
- Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. (2016) (74)
- Dynamic antibody-binding properties in the pathogenesis of HIT. (2012) (73)
- Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. (2015) (72)
- Heparin‐induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly (2007) (72)
- Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. (2003) (72)
- The α Subunits of Gz and Gi Interact with the eyes absent Transcription Cofactor Eya2, Preventing Its Interaction with the Six Class of Homeodomain-containing Proteins* (2000) (69)
- Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. (2012) (69)
- Factor V Leiden improves in vivo hemostasis in murine hemophilia models (2005) (69)
- Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation. (1993) (68)
- Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. (1994) (68)
- Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. (2013) (66)
- Structural requirements of platelet chemokines for neutrophil activation. (1994) (63)
- The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. (2015) (63)
- Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. (2001) (62)
- Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). (1996) (62)
- The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. (2008) (61)
- Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. (1998) (60)
- FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. (2009) (60)
- High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. (2014) (60)
- An Sp1-binding Silencer Element Is a Critical Negative Regulator of the Megakaryocyte-specific αIIb Gene* (1998) (59)
- A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3 (2000) (58)
- RGD-containing Peptides Inhibit Fibrinogen Binding to Platelet αIIbβ3 by Inducing an Allosteric Change in the Amino-terminal Portion of αIIb * (2001) (57)
- Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (1991) (55)
- Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. (2012) (55)
- In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. (2010) (54)
- Platelet glycoprotein IIb gene expression as a model of megakaryocyte‐specific expression (1995) (53)
- Platelet‐delivered factor VIII provides limited resistance to anti‐factor VIII inhibitors (2008) (53)
- SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. (2012) (52)
- Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia. (2016) (51)
- Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis (2010) (51)
- Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes (1991) (49)
- Activation of the Megakaryocyte-specific Gene Platelet Basic Protein (PBP) by the Ets Family Factor PU.1* (1997) (48)
- Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. (1990) (47)
- Interactions of platelet factor 4 with the vessel wall. (2004) (47)
- Serpin functions in host-pathogen interactions (2018) (47)
- Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two unrelated males based on studies of maternal T cell X chromosome inactivation. (1990) (47)
- Determinants of the intracellular fate of truncated forms of the platelet glycoproteins IIb and IIIa. (1993) (46)
- PF4/heparin complexes are T cell-dependent antigens. (2005) (46)
- Relative contributions of stromal interaction molecule 1 and CalDAG‐GEFI to calcium‐dependent platelet activation and thrombosis (2011) (45)
- Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. (2009) (44)
- CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. (2016) (43)
- A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart. (1993) (43)
- Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. (2015) (42)
- Platelet‐Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury (2016) (42)
- The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21). (2016) (42)
- Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. (1992) (42)
- Effect of deletion of glycoprotein IIb exon 28 on the expression of the platelet glycoprotein IIb/IIIa complex. (1991) (42)
- Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis. (1991) (41)
- Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. (1991) (41)
- Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. (1996) (40)
- Agonist receptors and G proteins as mediators of platelet activation. (1993) (39)
- GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting. (2018) (38)
- Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. (2007) (37)
- Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. (2005) (37)
- Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing. (1990) (36)
- FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. (2017) (36)
- Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. (2008) (35)
- Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. (2018) (34)
- Therapy of congenital folate malabsorption. (1981) (34)
- Human platelet factor 4 gene is mapped to 4q12----q21. (1987) (34)
- Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes. (1991) (34)
- The Human Platelet IIb Gene Is Not Closely Linked to Its Integrin Partner β3 (1999) (34)
- Detection of a novel DNA polymorphism in the beta-globin gene cluster. (1984) (34)
- Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. (2011) (33)
- The disulfide isomerase ERp72 supports arterial thrombosis in mice. (2017) (33)
- Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. (2001) (32)
- Mechanistic basis of heparin-induced thrombocytopenia. (2005) (31)
- Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia (2017) (31)
- Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contribute to thrombus propagation. (2020) (31)
- Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. (2018) (30)
- Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models. (2015) (29)
- Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake. (2017) (29)
- Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages (2015) (28)
- Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. (2015) (28)
- The disulfide isomerase ERp57 is required for fibrin deposition in vivo (2014) (28)
- In vivo characterization of the integrin β3 as a receptor for Hantaan virus cellular entry (2005) (28)
- Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation (2014) (27)
- The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. (1984) (27)
- RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb). (2001) (27)
- Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. (2016) (26)
- T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept. (2014) (25)
- A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. (2015) (25)
- ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. (2017) (25)
- Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression. (2002) (25)
- A Leu117 → Trp mutation within the RGD-peptide cross-linking region of β3 results in Glanzmann thrombasthenia by preventing αIIbβ3 export to the platelet surface (1997) (25)
- Induced Pluripotent Stem Cell–Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications (2017) (24)
- Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. (2015) (23)
- The biological basis of immune heparin-induced thrombocytopenia. (1998) (23)
- Platelet and monocyte antigenic complexes in the pathogenesis of heparin‐induced thrombocytopenia (HIT) (2009) (22)
- Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis (2020) (22)
- Agonist-stimulated Ligand Binding by the Platelet Integrin αIIbβ3 in a Lymphocyte Expression System (*) (1995) (22)
- Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. (2011) (21)
- Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. (2009) (21)
- Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation (2014) (20)
- A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3. (2000) (20)
- Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis (2020) (20)
- The human platelet alphaIIb gene is not closely linked to its integrin partner beta3. (1999) (19)
- Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet‐based gene therapy (2014) (19)
- Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa. (1996) (19)
- ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model (2016) (19)
- Elevated common acute lymphoblastic leukemia antigen expression in pediatric immune thrombocytopenic purpura. (1991) (18)
- Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment. (2016) (18)
- Distinct Domains of αIIbβ3 Support Different Aspects of Outside-In Signal Transduction and Platelet Activation Induced by LSARLAF, an αIIbβ3 Interacting Peptide (2001) (18)
- Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors. (2018) (17)
- Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. (2009) (16)
- Hematologic changes during acute chest syndrome in sickle cell disease. (1985) (15)
- Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. (2017) (15)
- Medical Countermeasures for Platelet Regeneration after Radiation Exposure (2011) (15)
- Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. (2021) (15)
- Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules (2015) (15)
- Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 (2021) (14)
- Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) (1998) (14)
- The role of platelet factor 4 in radiation-induced thrombocytopenia. (2011) (14)
- Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis (2017) (13)
- Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through Fc g RIIA (2001) (13)
- Current status of blood ‘pharming’: megakaryoctye transfusions as a source of platelets (2017) (13)
- Globin gene expression in hereditary persistence of fetal haemoglobin and (delta beta) (0)-thalassaemia. (1988) (13)
- FcRn augments induction of tissue factor activity by IgG-containing immune complexes. (2020) (13)
- Immune Vascular Injury in Heparin- Induced Thrombocytopenia (2003) (13)
- Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia (1991) (12)
- Long-term treatment of congenital folate malabsorption. (1996) (12)
- Role of monocytes and endothelial cells in heparin-induced thrombocytopenia (2016) (12)
- Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. (2011) (12)
- A large deletion encompassing the entire alpha-like globin gene cluster in a family of northern European extraction. (1988) (12)
- The Role of Surface PF4: Glycosaminoglycan Complexes in the Pathogenesis of Heparin-Induced Thrombocytopenia (HIT) (2006) (12)
- Development and Licensure of Medical Countermeasures for Platelet Regeneration after Radiation Exposure (2011) (11)
- Platelet factor 4 limits Th 17 differentiation and cardiac allograft rejection (2014) (11)
- Characterization of the Murine Platelet IIb Gene and Encoded cDNA (1999) (11)
- Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A. (2019) (10)
- Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect (2017) (10)
- Pre‐clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice (2019) (10)
- DNA methylation in hereditary persistence of fetal hemoglobin (HPFH-2) (1987) (10)
- Inherited Mutations within the Calcium-Binding Sites of the Integrin αIIb Subunit (Platelet Glycoprotein IIb) (1996) (10)
- The Regulated Expression of a TATA‐Less, Platelet‐Specific Gene, αIIb (1996) (10)
- A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface. (1997) (9)
- Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 (2022) (9)
- RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. (2021) (9)
- A Taq 1 polymorphism for the human platelet glycoprotein IIIa gene (GP3A). (1988) (9)
- The relative role of PLC and PI3K in platelet activation (2017) (9)
- Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability (2019) (8)
- Neutrophils promote clearance of nuclear debris following acid-induced lung injury. (2020) (8)
- Construction and Activity Analysis of Chimeric Interleukin-8 Receptor for Chemokine Binding (1995) (8)
- Platelet‐delivered therapeutics (2015) (8)
- DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION (1984) (8)
- Non-random association of the Rsa I polymorphic site 5' to the beta-globin gene with major sickle cell haplotypes. (1988) (8)
- Population based frequency of naturally occurring loss‐of‐function variants in genes associated with platelet disorders (2020) (8)
- Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding. (1996) (7)
- Oral and Poster Presentations (2003) (7)
- Characterization of the murine platelet alphaIIb gene and encoded cDNA. (1999) (7)
- RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. (2020) (7)
- Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model (2021) (7)
- The regulated expression of a TATA-less, platelet-specific gene, alphaIIb. (1996) (7)
- Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT). (2018) (7)
- Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. (2018) (7)
- 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. (2018) (6)
- Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges (2018) (6)
- In Vitro Studies of Recombinant Human Platelet Factor 4: Inhibition of Megakaryocytopoiesis and Angiogenesis (1995) (6)
- Unusual manifestations of chronic granulomatous disease. (1981) (6)
- Transcription Factors Involved in Lineage‐specific Gene Expression During Megakaryopoiesis (2002) (6)
- Vocal Cord Paralysis and Mediastinal Mass (1978) (6)
- Identification of G , , as a Pertussis Toxin-Insensitive G Protein in Human Platelets and Megakaryocytes (6)
- Threading an elephant through the eye of a needle: Where are platelets made? (2017) (5)
- An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene (1987) (5)
- Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same? (2011) (5)
- Glanzmann Thrombasthenia Due to a Two Amino Acid Deletion in the Fourth Calcium-Binding Domain of a ! IIb : Demonstration of the Importance of Calcium-Binding Domains in the Conformation of a ! II , , pJ (2002) (5)
- Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. (2001) (5)
- Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis. (2019) (4)
- They're not your daddy's inherited platelet disorders anymore (2013) (4)
- Platelet factor 4 platelet levels are inversely correlated with steady‐state platelet counts and with platelet transfusion needs in pediatric leukemia patients (2012) (4)
- Inducible Gata 1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells (2019) (4)
- Platelet message and microarrays (2003) (4)
- Characterizing Factor VIII Inhibitor Resistance of Platelet-Delivered Factor VIII in the Treatment of Hemophilia A. (2007) (4)
- Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf (2011) (4)
- Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis (2018) (4)
- Gp1ba-Cre or Pf4-Cre: pick your poison. (2019) (4)
- Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. (2020) (4)
- Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice. (2020) (4)
- Platelet CXCL7 and CXCL4 inhibit chemokine scavenging and improve innate immunity to bacterial infection (P1317) (2013) (3)
- Agonist-stimulated ligand binding by the platelet integrin alpha IIb beta 3 in a lymphocyte expression system. (1995) (3)
- BACH and the megakaryocyte symphony (2005) (3)
- Frequent occurrence of a zeta-globin-region deletion in American blacks accounts for a previously-described restriction site polymorphism. (1984) (3)
- A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. (2021) (3)
- In vitro expansion of megakaryocytes from peripheral blood hematopoietic progenitors. (1999) (3)
- Megakaryocytes Exchange Significant Levels of Their Alpha-Granular PF4 with Their Environment (2014) (3)
- Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders (2012) (3)
- Structural and Functional Studies to Define the Molecular Basis by Which Platelet Factor 4 (PF4) Increases Survival of Mice in Lipopolysaccharide (LPS)-Induced Endotoxicity (2008) (3)
- Heparin-induced thrombocytopenia / thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcRIIA (2001) (3)
- Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel (cid:1) IIb-specific (cid:1) IIb (cid:2) 3 antagonist (2009) (3)
- Hematology grants workshop. (2003) (3)
- Microfluidic and Flow Cytometric Studies Support a Role for Monocytes and Coated Platelets in the Prothrombotic State in Heparin-Induced Thrombocytopenia (HIT) (2011) (2)
- formation in vitro and in vivo Cooperative integrin/ITAM signaling in platelets enhances thrombus (2013) (2)
- A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics (2015) (2)
- Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura (2015) (2)
- Congenital folate malabsorption. (1981) (2)
- ISOLATION AND CHARACTERIZATION OF cDNA CLONES FOR THE PLATELET MEMBRANE GLYCOPROTEINS IIb and IIIa (1987) (2)
- A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models (2014) (2)
- 2-O, 3-O-Desulfated Heparin (ODSH) Mitigates Chemotherapy-Induced Thrombocytopenia (CIT) by Blocking the Negative Paracrine Effect of Platelet Factor 4 (PF4) On Megakaryopoiesis (2012) (2)
- Molecular biology of the megakaryocyte-specific gene platelet factor 4. (1990) (2)
- Atherosclerosis is not a risk factor for antiplatelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery (2014) (2)
- Pathogenic Role of Surface Platelet Factor 4 Complexes in Heparin-Induced Thrombocytopenia: Diagnostic and Therapeutic Implications. (2005) (2)
- Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications (2021) (2)
- Mechanisms for mentored career development: the NIH research career awards and other national awards. (2007) (2)
- Fli1 Expression Level Affects Megakaryopoiesis and Thrombopoiesis: More Is Not Always a Bad Thing (2016) (1)
- The Two Phases of Heparin-Induced Thrombocytopenia (HIT): Early Monocyte/Tissue Factor (TF) Phase and Late Platelet Phase (2012) (1)
- Monocytes Are a Particularly Favorable Target for Surface Platelet Factor 4 (PF4) Antigenic Complex Formation in Heparin-Induced Thrombocytopenia: New Insights into the Thrombotic Risk in HIT (2008) (1)
- Formation of Procoagulant Platelets in Heparin-Induced Thrombocytopenia (HIT) Follows a Unique Signaling Pathway (2011) (1)
- Molecular biological identification and characterization of inherited platelet receptor disorders. (1999) (1)
- Platelets Can Soak It Up and Then Spit It Out. (2018) (1)
- Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT) (2014) (1)
- “Rolling Recruitment” of Endothelial Cell (EC) Activation in the Prothrombotic Nature of Heparin-Induced Thrombocytopenia (HIT) (2011) (1)
- CHAPTER 54 – Inherited Thrombocytopenias (2007) (1)
- G Proteins and the Early Events of Platelet Activation (1997) (1)
- Chapter 47 – Inherited Thrombocytopenias (2013) (1)
- Visualizing the Molecular and Cellular Basis of Heparin Induced Thrombocytopenia. (2009) (1)
- Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model. (2005) (1)
- Platelet Factor 4 Levels Inversely Correlate with Platelet Transfusion Needs In Pediatric Patients Treated for Standard Risk Acute Lymphoblastic Leukemia (2010) (1)
- Personalized platelet transfusions: one step closer to the clinic. (2014) (1)
- Understanding VITT(ual) reality (2021) (1)
- Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis (2021) (1)
- Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis (2022) (1)
- Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy (2021) (1)
- Fibrin Generation in Heparin-Induced Thrombocytopenia (HIT): Pathomechanistic Background for Novel Therapy and Prophylaxis (2012) (1)
- Making Platelets Ex Vivo (2013) (1)
- Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency (2022) (1)
- Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT) (2013) (1)
- Defining the Role of Monocytes in Heparin-Induced Thrombocytopenia (HIT): Insights from a Murine HIT Model. (2007) (1)
- Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis. (2019) (1)
- Murine In Vivo Studies Support Platelet Factor 4 as a Negative Autocrine of Megakaryopoiesis with Clinical and Therapeutic Implications. (2006) (1)
- Platelet Factor 4 (PF4) Is Selectively Recycled During Megakaryopoiesis (2012) (1)
- Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge (2017) (1)
- Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals (2018) (1)
- Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice (2013) (1)
- Infusing Mature Megakaryocytes Into Mice Yields Functional Platelets: Biological and Clinical Implications. (2009) (1)
- FcγRIIa Enhances Thrombus Growth in Vitro and in Vivo (2011) (1)
- A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia (2016) (1)
- Von Willebrand Factor Facilitates Intravascular Dissemination of Microsporidia Encephalitozoon hellem (2021) (1)
- Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin (2010) (1)
- Expression of Urokinase-Type Plasminogen Activator in Platelets Decreases Oxygen-Induced Lung Injury in Mice. (2004) (1)
- “Leucine Sensitive Hypoglycemia” Caused by a Dominantly-inherited Mutation of Glutamate Dehydrogenase • 442 (1998) (1)
- The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis (2015) (1)
- Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts (2022) (1)
- Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models. (2012) (1)
- Relative contribution of STIM1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis (2011) (1)
- Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction (2010) (1)
- Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation (2016) (1)
- essential for expression of this TATA-less gene specific alpha IIb gene appears to stabilize Sp1 binding and is An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte- (2011) (0)
- thrombocytopenia pathogenesis: diagnostic and therapeutic implications Role of platelet surface PF4 antigenic complexes in heparin-induced (2013) (0)
- growth and polyploidization Cdk4 is regulated by GATA-1 and required for megakaryocyte - Cyclin D (2013) (0)
- FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT (2014) (0)
- A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT) (2015) (0)
- Pigment Cells Mechanisms of Protein Delivery to Melanosomes in (2015) (0)
- Neutrophil extracellular trap stabilization leads to improved outcomes in murine models of sepsis (2019) (0)
- SLFN14 ribosomopathy and platelet dysfunction. (2023) (0)
- Strategies to Enhance the Efficacy of Platelet-Derived Factor (F) VIII: Studies with Inactivation Resistant FVIII (IR8) and Canine FVIII in Hemophilia A Mice. (2009) (0)
- Fusion of uPA to Anti-aIIbb3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis (2022) (0)
- Cyclin D/CDK4/6 kinase activity, regulated by GATA1, is required for megakaryocyte polyploidization (2007) (0)
- Effect of folic and folinic acid on serum and CSF folate levels in congenital folate malabsorption. (1980) (0)
- Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT) (2012) (0)
- Conditional Knockout of LRP1 in Murine Megakaryocytes and Its Affects on Platelet Factor 4 Biology in Megakaryocytes (2014) (0)
- Molecular biology studies with primary megakaryocytes. (1999) (0)
- Cyclin D: CDK4/6 Kinase Activity, Regulated by GATA-1, Is Required for Megakaryocyte Polyploidization. (2006) (0)
- human erythroleukemic cell line Cloning and characterization of platelet factor 4 cDNA derived from a (2010) (0)
- Platelet-Delivered Factor VIII (FVIII) Decreases Thrombus Stability. (2006) (0)
- Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs) (2012) (0)
- Platelet Factor 4 (PF4) Levels Are Inversely Correlated with Steady-State Platelet Counts and with Nadir Counts in Chemotherapy-Induced Thrombocytopenia (CIT), (2011) (0)
- Murine (m) alphaIIbeta out-competes human (h) alphaIIb for mouse beta3 in a transgenic mouse model: Implications for integrin subunit interactions (2003) (0)
- PLATELETS AND THROMBOPOIESIS Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia (2016) (0)
- Title: Signaling through Fc g RIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 One-sentence summary: The Fc g RIIA and C5a-C5aR pathways mediate platelet hyperactivation in COVID-19 (2021) (0)
- Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. (2022) (0)
- The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis (2015) (0)
- FDG-PET IMAGING OF CLOTS: NEW ANIMAL MODEL BASED UPON THE FERRIC CHLORIDE INJURY MODEL (2005) (0)
- A naturally occurring mutation near the amino terminus of a IIb defines a new region involved in ligand binding to a IIb b 3 (1999) (0)
- RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction (2020) (0)
- RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation (2012) (0)
- Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules (2021) (0)
- Comment on Nagy et al , page 331 Gp 1 baCre or Pf 4-Cre : pick your poison (2019) (0)
- Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT) (2012) (0)
- A(nother) day in the life of neonatal platelets. (2014) (0)
- Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656 (2016) (0)
- Negative Paracrine Effect of Platelet Factor 4 on Megakaryopoiesis Occurs through Lipoprotein Related Protein Receptor-1 on Megakaryocytes. (2007) (0)
- A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice (2018) (0)
- demonstrate identity with the native protein Biologic and biochemic properties of recombinant platelet factor 4 (2011) (0)
- Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells (2014) (0)
- Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy (2010) (0)
- In Situ Microscopy Studies of Infused Megakaryocytes: Implications in Thrombopoiesis (2021) (0)
- The Signaling Molecule CalDAG-GEFI Represents a Novel Target for Antithrombotic Therapy. (2009) (0)
- Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis (2022) (0)
- Intrinsic Deficiency of PAI-1 in Human Pulmonary Arterial Smooth Muscle Cells From Pulmonary Artery Hypertension (PAH) Patients Drives UPA-dependent Cell Proliferation and Induces Spontaneous Pulmonary Hypertension in Mice (2023) (0)
- Towards the Care of Hemophilia a Patients Using Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Expressing Coagulation Factor (F) VIII (2015) (0)
- CDNA AND GENOMIC CLONES FOR HUMAN PLATELET GLYCOPROTEIN lib (GPIIb) (1987) (0)
- in platelet activation γ and PI3K β The relative role of PLC (2013) (0)
- Nanogel Drug Carriers Presenting Platelet GPIbα Mimic and Enhance Platelet Adhesion (2016) (0)
- The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression. (2008) (0)
- Endogenous Platelet PF4 Promotes In Vivo Activated Protein C (APC) Generation and Survival after Lethal Lipopolysaccharide Challenge in Mice: A Potential Physiologic Role for PF4. (2005) (0)
- Factor (F) VIII Is Stored in Platelets Independent of Von Willebrand Factor (VWF). (2004) (0)
- The Influence of FLI1 Expression Levels on Megakaryopoiesis: Studies Using iPSCs (2015) (0)
- S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes (2023) (0)
- THROMBOSIS AND HEMOSTASIS Cooperative integrin / ITAM signaling in platelets enhances thrombus formation in vitro and in vivo (2013) (0)
- Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia (2010) (0)
- Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice (2013) (0)
- Inherited Thrombocytopenias (2019) (0)
- Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis (2019) (0)
- necessary for consistent, high-level megakaryocyte expression IIb gene locus α Identification of distal regulatory regions in the human (2013) (0)
- Platelet Factor 4 (PF4) Antigenic Complexes on the Macrophage Surface: Implications for the Pathogenesis of Heparin Induced Thrombocytopenia (HIT). (2006) (0)
- Comparative Analysis of Infused “Static”, Ex Vivo-Generated Platelets Vs. Infused Megakaryocytes-Generated Platelets: A Cautionary Tale (2014) (0)
- Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia (2015) (0)
- Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia (2015) (0)
- thrombi in mice: implications for antiplatelet therapy 3 activation determines the size and stability of β (2013) (0)
- Utilizing CRISPR-CAS9 Gene Editing Technology in Human Pluripotent Stem Cells to Study Platelet Integrin αIIbβ3 Function (2020) (0)
- Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis (2020) (0)
- Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides. (2005) (0)
- Platelet Factor 4 Regulates Platelet Count In Vivo: Implications for Platelet Recovery after Cytotoxic Therapy. (2005) (0)
- Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges (2018) (0)
- conserved domains and alternative proteolytic processing Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily (2011) (0)
- New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation (2014) (0)
- Polymerase chain reaction (PCR) for detection of PstI polymorphism in the human PF4 gene. (1990) (0)
- 852 THROMBOCYTOSIS IN PATIENTS WITH SICKLE CELL ANEMIA AND PNEUMONIA (1981) (0)
- Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3 (2011) (0)
- THROMBOSIS AND HEMOSTASIS The disul fi de isomerase ERp 72 supports arterial thrombosis in mice (2017) (0)
- Exploiting Induced Pluripotent Stem Cells to Unravel Mechanisms in Inherited Platelet/Megakaryocyte Disorders (2020) (0)
- Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment (2016) (0)
- Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells (2014) (0)
- Release of High Levels of Platelet Factor 4 (PF4) from Platelets Improves Survival after a Lethal Lipopolysaccharide (LPS) Challenge. (2006) (0)
- Complement Regulates the Procoagulant Effects of HIT Immune Complexes (2020) (0)
- PLATELETS AND THROMBOPOIESIS CRISPR / Cas 9-mediated conversion of human platelet alloantigen allotypes (2016) (0)
- Platelet Release from Infused CD34+-Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor (2016) (0)
- Platelet Factor 4 (PF4) Causes Cell Cycle Arrest in Megakaryocytes (Megs) by Inactivating CDC2 (CDK1) and CDK2 (2012) (0)
- A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis (2019) (0)
- THROMBOSIS AND HEMOSTASIS Platelet-delivered ADAMTS 13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models (2015) (0)
- cell surface endocytic itinerary, resulting in retention of low-density lipoprotein on the Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the (2013) (0)
- Expansion of Platelets for Transfusion (2010) (0)
- A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis (2014) (0)
- Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy (2016) (0)
- Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity (2015) (0)
- RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects: Therapeutic implications (2022) (0)
- Structure-guided design of a pure orthosteric antagonist of integrin αlIbβ3 that inhibits thrombosis but not clot retraction (2018) (0)
- ACUTE CHEST SYNDROME (ACS) IN SICKLE CELL PATIENTS IS OFTEN DUE TO MYCOPLASMA PNEUMONIAE (1984) (0)
- Species differences in small molecule binding to (cid:1) IIb (cid:2) 3 are the result of sequence differences in 2 loops of the (cid:1) IIb (cid:2) propeller (2009) (0)
- Platelet Factor VIII-Induced Megakaryocyte Apoptosis: Implications for Hemophilia A Gene Therapy (2012) (0)
- Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia (2018) (0)
- Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT) (2013) (0)
- Corrigenda (2006) (0)
- The GATA-1/FOG-1/NuRD Axis Is Essential for Normal Hematopoiesis. (2007) (0)
- Demonstration that platelet-expressed human B-domainless Factor VIII can ameliorate the bleeding diathesis in a murine model of hemophilia A (2003) (0)
- Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs (2022) (0)
- Peroxisome Proliferator-Activated Receptor gamma (PPARγ) Regulates CD36 Gene Expression in Megakaryocytic Cell Lines. (2006) (0)
- of heparin-induced thrombocytopenia Ultralarge complexes of PF4 and heparin are central to the pathogenesis (2010) (0)
- inactivation (see comments) unrelated males based on studies of maternal T cell X chromosome Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two (2011) (0)
- activation Structural requirements of platelet chemokines for neutrophil (2011) (0)
- antibodies using KKO, a murine HIT-like monoclonal antibody Defining a second epitope for heparin-induced thrombocytopenia/thrombosis (2013) (0)
- Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic? (2022) (0)
- Journal of Bone Marrow Research (0)
- Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis (2013) (0)
- The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction (2019) (0)
- Histones, Like Platelet Factor 4 (PF4), Affect Generation of Activated Protein C: Implications for the Pathogenesis of Severe Sepsis (2011) (0)
- A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis (2019) (0)
- Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury (2023) (0)
- Polyreactive IgM initiates complement activation by PF 4 / heparin complexes through the classical pathway Running Title : IgM involvement in the HIT Immune Response (2018) (0)
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