Mortimer Poncz

Q: What Schools Are Affiliated With Mortimer Poncz

Mortimer Poncz is affiliated with the following schools: Medical College of Wisconsin, University of Alberta, Florida A&M University, Medical University of South Carolina, Duke University, University of Cambridge, University of Pennsylvania, Korea University

Mortimer Poncz's AcademicInfluence.com Rankings

Mortimer Poncz

Philosophy

#9040

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#12536

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Logic

#6042

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#7521

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philosophy Degrees

Mortimer Poncz

Biology

#12369

World Rank

#15840

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Molecular Biology

#1996

World Rank

#2028

Historical Rank

biology Degrees

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Philosophy
Biology

Mortimer Poncz's Degrees

PhD Molecular Biology University of California, San Francisco
Doctorate Medicine Stanford University

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Mortimer Poncz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia (1999) (1053)
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. (1998) (628)
Construction of human gene libraries from small amounts of peripheral blood: analysis of beta-like globin genes. (1982) (595)
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1 (2000) (503)
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. (1987) (368)
Megakaryocytes regulate hematopoietic stem cell quiescence via Cxcl4 secretion (2013) (335)
Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. (1997) (325)
Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV (2003) (323)
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. (2005) (247)
Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. (2006) (229)
Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. (1996) (226)
Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. (2000) (201)
The genomic organization of platelet glycoprotein IIIa. (1990) (197)
"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method. (1982) (192)
Organization of the gene for platelet glycoprotein IIb. (1990) (190)
Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. (2001) (190)
Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. (1995) (189)
Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters (2003) (179)
Control of megakaryocyte‐specific gene expression by GATA‐1 and FOG‐1: role of Ets transcription factors (2002) (171)
Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. (2000) (165)
Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. (1987) (161)
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. (2010) (158)
Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. (2003) (156)
NuRD mediates activating and repressive functions of GATA‐1 and FOG‐1 during blood development (2010) (154)
Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. (2004) (145)
Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. (2000) (143)
Megakaryocyte precursors, megakaryocytes and platelets express the HIV co‐receptor CXCR4 on their surface: determination of response to stromal‐derived factor‐1 by megakaryocytes and platelets (1999) (143)
Megakaryocyte biology and related disorders. (2005) (141)
Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. (2010) (136)
Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. (2010) (133)
Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells* (2003) (130)
Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. (2000) (126)
Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. (2007) (125)
Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. (1997) (125)
The relative role of PLCbeta and PI3Kgamma in platelet activation. (2005) (124)
Chemokine regulation of human megakaryocytopoiesis. (1995) (123)
Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (1990) (120)
Infusion of mature megakaryocytes into mice yields functional platelets. (2010) (118)
Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. (2000) (118)
Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. (2002) (113)
Determinants of PF4/heparin immunogenicity. (2007) (112)
Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. (1987) (111)
Molecular Basis and Characterization of the Hyperinsulinism/Hyperammonemia Syndrome Predominance of Mutations in Exons 11 and 12 of the Glutamate Dehydrogenase Gene (2000) (111)
Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. (1988) (109)
Acute chest syndrome in sickle cell disease: etiology and clinical correlates. (1985) (108)
Receptor and G protein-mediated responses to thrombin in HEL cells. (1991) (106)
A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. (1991) (101)
Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine (2007) (100)
Neutrophil accumulation and NET release contribute to thrombosis in HIT. (2018) (99)
Nucleotide sequence analysis of the delta beta-globin gene region in humans. (1983) (95)
Rapid detection of the ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED) (1996) (94)
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. (2013) (93)
An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. (1996) (93)
Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. (1994) (93)
Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. (2002) (93)
Challenges and promises for the development of donor-independent platelet transfusions. (2013) (92)
Atomic description of the immune complex involved in heparin-induced thrombocytopenia (2015) (91)
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. (2010) (91)
Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. (2007) (90)
Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. (2016) (90)
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. (2005) (90)
Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. (2002) (85)
Towards a standardization of the murine tail bleeding model (2010) (84)
Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. (2014) (83)
beta-Thalassemia in a Kurdish Jew. Single base changes in the T-A-T-A box. (1982) (81)
Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. (1990) (80)
Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia (1998) (80)
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions (1984) (79)
Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. (2008) (78)
Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. (2012) (75)
The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. (2011) (75)
Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. (2016) (74)
Dynamic antibody-binding properties in the pathogenesis of HIT. (2012) (73)
Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. (2015) (72)
Heparin‐induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly (2007) (72)
Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. (2003) (72)
The α Subunits of Gz and Gi Interact with the eyes absent Transcription Cofactor Eya2, Preventing Its Interaction with the Six Class of Homeodomain-containing Proteins* (2000) (69)
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. (2012) (69)
Factor V Leiden improves in vivo hemostasis in murine hemophilia models (2005) (69)
Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation. (1993) (68)
Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. (1994) (68)
Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. (2013) (66)
Structural requirements of platelet chemokines for neutrophil activation. (1994) (63)
The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. (2015) (63)
Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. (2001) (62)
Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). (1996) (62)
The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. (2008) (61)
Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. (1998) (60)
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. (2009) (60)
High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. (2014) (60)
An Sp1-binding Silencer Element Is a Critical Negative Regulator of the Megakaryocyte-specific αIIb Gene* (1998) (59)
A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3 (2000) (58)
RGD-containing Peptides Inhibit Fibrinogen Binding to Platelet αIIbβ3 by Inducing an Allosteric Change in the Amino-terminal Portion of αIIb * (2001) (57)
Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. (1991) (55)
Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. (2012) (55)
In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. (2010) (54)
Platelet glycoprotein IIb gene expression as a model of megakaryocyte‐specific expression (1995) (53)
Platelet‐delivered factor VIII provides limited resistance to anti‐factor VIII inhibitors (2008) (53)
SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. (2012) (52)
Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia. (2016) (51)
Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis (2010) (51)
Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes (1991) (49)
Activation of the Megakaryocyte-specific Gene Platelet Basic Protein (PBP) by the Ets Family Factor PU.1* (1997) (48)
Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. (1990) (47)
Interactions of platelet factor 4 with the vessel wall. (2004) (47)
Serpin functions in host-pathogen interactions (2018) (47)
Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two unrelated males based on studies of maternal T cell X chromosome inactivation. (1990) (47)
Determinants of the intracellular fate of truncated forms of the platelet glycoproteins IIb and IIIa. (1993) (46)
PF4/heparin complexes are T cell-dependent antigens. (2005) (46)
Relative contributions of stromal interaction molecule 1 and CalDAG‐GEFI to calcium‐dependent platelet activation and thrombosis (2011) (45)
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. (2009) (44)
CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. (2016) (43)
A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart. (1993) (43)
Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. (2015) (42)
Platelet‐Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury (2016) (42)
The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21). (2016) (42)
Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. (1992) (42)
Effect of deletion of glycoprotein IIb exon 28 on the expression of the platelet glycoprotein IIb/IIIa complex. (1991) (42)
Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis. (1991) (41)
Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. (1991) (41)
Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. (1996) (40)
Agonist receptors and G proteins as mediators of platelet activation. (1993) (39)
GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting. (2018) (38)
Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. (2007) (37)
Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII. (2005) (37)
Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing. (1990) (36)
FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. (2017) (36)
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. (2008) (35)
Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. (2018) (34)
Therapy of congenital folate malabsorption. (1981) (34)
Human platelet factor 4 gene is mapped to 4q12----q21. (1987) (34)
Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes. (1991) (34)
The Human Platelet IIb Gene Is Not Closely Linked to Its Integrin Partner β3 (1999) (34)
Detection of a novel DNA polymorphism in the beta-globin gene cluster. (1984) (34)
Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. (2011) (33)
The disulfide isomerase ERp72 supports arterial thrombosis in mice. (2017) (33)
Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. (2001) (32)
Mechanistic basis of heparin-induced thrombocytopenia. (2005) (31)
Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia (2017) (31)
Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contribute to thrombus propagation. (2020) (31)
Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. (2018) (30)
Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models. (2015) (29)
Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake. (2017) (29)
Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages (2015) (28)
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. (2015) (28)
The disulfide isomerase ERp57 is required for fibrin deposition in vivo (2014) (28)
In vivo characterization of the integrin β3 as a receptor for Hantaan virus cellular entry (2005) (28)
Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation (2014) (27)
The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. (1984) (27)
RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb). (2001) (27)
Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. (2016) (26)
T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept. (2014) (25)
A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. (2015) (25)
ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. (2017) (25)
Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression. (2002) (25)
A Leu117 → Trp mutation within the RGD-peptide cross-linking region of β3 results in Glanzmann thrombasthenia by preventing αIIbβ3 export to the platelet surface (1997) (25)
Induced Pluripotent Stem Cell–Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications (2017) (24)
Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. (2015) (23)
The biological basis of immune heparin-induced thrombocytopenia. (1998) (23)
Platelet and monocyte antigenic complexes in the pathogenesis of heparin‐induced thrombocytopenia (HIT) (2009) (22)
Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis (2020) (22)
Agonist-stimulated Ligand Binding by the Platelet Integrin αIIbβ3 in a Lymphocyte Expression System (*) (1995) (22)
Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. (2011) (21)
Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. (2009) (21)
Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation (2014) (20)
A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3. (2000) (20)
Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis (2020) (20)
The human platelet alphaIIb gene is not closely linked to its integrin partner beta3. (1999) (19)
Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet‐based gene therapy (2014) (19)
Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa. (1996) (19)
ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model (2016) (19)
Elevated common acute lymphoblastic leukemia antigen expression in pediatric immune thrombocytopenic purpura. (1991) (18)
Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment. (2016) (18)
Distinct Domains of αIIbβ3 Support Different Aspects of Outside-In Signal Transduction and Platelet Activation Induced by LSARLAF, an αIIbβ3 Interacting Peptide (2001) (18)
Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors. (2018) (17)
Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. (2009) (16)
Hematologic changes during acute chest syndrome in sickle cell disease. (1985) (15)
Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation. (2017) (15)
Medical Countermeasures for Platelet Regeneration after Radiation Exposure (2011) (15)
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. (2021) (15)
Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules (2015) (15)
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 (2021) (14)
Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) (1998) (14)
The role of platelet factor 4 in radiation-induced thrombocytopenia. (2011) (14)
Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis (2017) (13)
Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through Fc g RIIA (2001) (13)
Current status of blood ‘pharming’: megakaryoctye transfusions as a source of platelets (2017) (13)
Globin gene expression in hereditary persistence of fetal haemoglobin and (delta beta) (0)-thalassaemia. (1988) (13)
FcRn augments induction of tissue factor activity by IgG-containing immune complexes. (2020) (13)
Immune Vascular Injury in Heparin- Induced Thrombocytopenia (2003) (13)
Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia (1991) (12)
Long-term treatment of congenital folate malabsorption. (1996) (12)
Role of monocytes and endothelial cells in heparin-induced thrombocytopenia (2016) (12)
Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. (2011) (12)
A large deletion encompassing the entire alpha-like globin gene cluster in a family of northern European extraction. (1988) (12)
The Role of Surface PF4: Glycosaminoglycan Complexes in the Pathogenesis of Heparin-Induced Thrombocytopenia (HIT) (2006) (12)
Development and Licensure of Medical Countermeasures for Platelet Regeneration after Radiation Exposure (2011) (11)
Platelet factor 4 limits Th 17 differentiation and cardiac allograft rejection (2014) (11)
Characterization of the Murine Platelet IIb Gene and Encoded cDNA (1999) (11)
Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A. (2019) (10)
Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect (2017) (10)
Pre‐clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice (2019) (10)
DNA methylation in hereditary persistence of fetal hemoglobin (HPFH-2) (1987) (10)
Inherited Mutations within the Calcium-Binding Sites of the Integrin αIIb Subunit (Platelet Glycoprotein IIb) (1996) (10)
The Regulated Expression of a TATA‐Less, Platelet‐Specific Gene, αIIb (1996) (10)
A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface. (1997) (9)
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 (2022) (9)
RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. (2021) (9)
A Taq 1 polymorphism for the human platelet glycoprotein IIIa gene (GP3A). (1988) (9)
The relative role of PLC and PI3K in platelet activation (2017) (9)
Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability (2019) (8)
Neutrophils promote clearance of nuclear debris following acid-induced lung injury. (2020) (8)
Construction and Activity Analysis of Chimeric Interleukin-8 Receptor for Chemokine Binding (1995) (8)
Platelet‐delivered therapeutics (2015) (8)
DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION (1984) (8)
Non-random association of the Rsa I polymorphic site 5' to the beta-globin gene with major sickle cell haplotypes. (1988) (8)
Population based frequency of naturally occurring loss‐of‐function variants in genes associated with platelet disorders (2020) (8)
Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding. (1996) (7)
Oral and Poster Presentations (2003) (7)
Characterization of the murine platelet alphaIIb gene and encoded cDNA. (1999) (7)
RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. (2020) (7)
Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model (2021) (7)
The regulated expression of a TATA-less, platelet-specific gene, alphaIIb. (1996) (7)
Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT). (2018) (7)
Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. (2018) (7)
2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. (2018) (6)
Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges (2018) (6)
In Vitro Studies of Recombinant Human Platelet Factor 4: Inhibition of Megakaryocytopoiesis and Angiogenesis (1995) (6)
Unusual manifestations of chronic granulomatous disease. (1981) (6)
Transcription Factors Involved in Lineage‐specific Gene Expression During Megakaryopoiesis (2002) (6)
Vocal Cord Paralysis and Mediastinal Mass (1978) (6)
Identification of G , , as a Pertussis Toxin-Insensitive G Protein in Human Platelets and Megakaryocytes (6)
Threading an elephant through the eye of a needle: Where are platelets made? (2017) (5)
An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene (1987) (5)
Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same? (2011) (5)
Glanzmann Thrombasthenia Due to a Two Amino Acid Deletion in the Fourth Calcium-Binding Domain of a ! IIb : Demonstration of the Importance of Calcium-Binding Domains in the Conformation of a ! II , , pJ (2002) (5)
Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. (2001) (5)
Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis. (2019) (4)
They're not your daddy's inherited platelet disorders anymore (2013) (4)
Platelet factor 4 platelet levels are inversely correlated with steady‐state platelet counts and with platelet transfusion needs in pediatric leukemia patients (2012) (4)
Inducible Gata 1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells (2019) (4)
Platelet message and microarrays (2003) (4)
Characterizing Factor VIII Inhibitor Resistance of Platelet-Delivered Factor VIII in the Treatment of Hemophilia A. (2007) (4)
Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf (2011) (4)
Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis (2018) (4)
Gp1ba-Cre or Pf4-Cre: pick your poison. (2019) (4)
Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. (2020) (4)
Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice. (2020) (4)
Platelet CXCL7 and CXCL4 inhibit chemokine scavenging and improve innate immunity to bacterial infection (P1317) (2013) (3)
Agonist-stimulated ligand binding by the platelet integrin alpha IIb beta 3 in a lymphocyte expression system. (1995) (3)
BACH and the megakaryocyte symphony (2005) (3)
Frequent occurrence of a zeta-globin-region deletion in American blacks accounts for a previously-described restriction site polymorphism. (1984) (3)
A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. (2021) (3)
In vitro expansion of megakaryocytes from peripheral blood hematopoietic progenitors. (1999) (3)
Megakaryocytes Exchange Significant Levels of Their Alpha-Granular PF4 with Their Environment (2014) (3)
Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders (2012) (3)
Structural and Functional Studies to Define the Molecular Basis by Which Platelet Factor 4 (PF4) Increases Survival of Mice in Lipopolysaccharide (LPS)-Induced Endotoxicity (2008) (3)
Heparin-induced thrombocytopenia / thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcRIIA (2001) (3)
Structural and therapeutic insights from the species speciﬁcity and in vivo antithrombotic activity of a novel (cid:1) IIb-speciﬁc (cid:1) IIb (cid:2) 3 antagonist (2009) (3)
Hematology grants workshop. (2003) (3)
Microfluidic and Flow Cytometric Studies Support a Role for Monocytes and Coated Platelets in the Prothrombotic State in Heparin-Induced Thrombocytopenia (HIT) (2011) (2)
formation in vitro and in vivo Cooperative integrin/ITAM signaling in platelets enhances thrombus (2013) (2)
A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics (2015) (2)
Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents murine models of thrombotic thrombocytopenic purpura (2015) (2)
Congenital folate malabsorption. (1981) (2)
ISOLATION AND CHARACTERIZATION OF cDNA CLONES FOR THE PLATELET MEMBRANE GLYCOPROTEINS IIb and IIIa (1987) (2)
A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models (2014) (2)
2-O, 3-O-Desulfated Heparin (ODSH) Mitigates Chemotherapy-Induced Thrombocytopenia (CIT) by Blocking the Negative Paracrine Effect of Platelet Factor 4 (PF4) On Megakaryopoiesis (2012) (2)
Molecular biology of the megakaryocyte-specific gene platelet factor 4. (1990) (2)
Atherosclerosis is not a risk factor for antiplatelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery (2014) (2)
Pathogenic Role of Surface Platelet Factor 4 Complexes in Heparin-Induced Thrombocytopenia: Diagnostic and Therapeutic Implications. (2005) (2)
Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications (2021) (2)
Mechanisms for mentored career development: the NIH research career awards and other national awards. (2007) (2)
Fli1 Expression Level Affects Megakaryopoiesis and Thrombopoiesis: More Is Not Always a Bad Thing (2016) (1)
The Two Phases of Heparin-Induced Thrombocytopenia (HIT): Early Monocyte/Tissue Factor (TF) Phase and Late Platelet Phase (2012) (1)
Monocytes Are a Particularly Favorable Target for Surface Platelet Factor 4 (PF4) Antigenic Complex Formation in Heparin-Induced Thrombocytopenia: New Insights into the Thrombotic Risk in HIT (2008) (1)
Formation of Procoagulant Platelets in Heparin-Induced Thrombocytopenia (HIT) Follows a Unique Signaling Pathway (2011) (1)
Molecular biological identification and characterization of inherited platelet receptor disorders. (1999) (1)
Platelets Can Soak It Up and Then Spit It Out. (2018) (1)
Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT) (2014) (1)
“Rolling Recruitment” of Endothelial Cell (EC) Activation in the Prothrombotic Nature of Heparin-Induced Thrombocytopenia (HIT) (2011) (1)
CHAPTER 54 – Inherited Thrombocytopenias (2007) (1)
G Proteins and the Early Events of Platelet Activation (1997) (1)
Chapter 47 – Inherited Thrombocytopenias (2013) (1)
Visualizing the Molecular and Cellular Basis of Heparin Induced Thrombocytopenia. (2009) (1)
Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model. (2005) (1)
Platelet Factor 4 Levels Inversely Correlate with Platelet Transfusion Needs In Pediatric Patients Treated for Standard Risk Acute Lymphoblastic Leukemia (2010) (1)
Personalized platelet transfusions: one step closer to the clinic. (2014) (1)
Understanding VITT(ual) reality (2021) (1)
Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis (2021) (1)
Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis (2022) (1)
Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy (2021) (1)
Fibrin Generation in Heparin-Induced Thrombocytopenia (HIT): Pathomechanistic Background for Novel Therapy and Prophylaxis (2012) (1)
Making Platelets Ex Vivo (2013) (1)
Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency (2022) (1)
Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT) (2013) (1)
Defining the Role of Monocytes in Heparin-Induced Thrombocytopenia (HIT): Insights from a Murine HIT Model. (2007) (1)
Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis. (2019) (1)
Murine In Vivo Studies Support Platelet Factor 4 as a Negative Autocrine of Megakaryopoiesis with Clinical and Therapeutic Implications. (2006) (1)
Platelet Factor 4 (PF4) Is Selectively Recycled During Megakaryopoiesis (2012) (1)
Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge (2017) (1)
Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals (2018) (1)
Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice (2013) (1)
Infusing Mature Megakaryocytes Into Mice Yields Functional Platelets: Biological and Clinical Implications. (2009) (1)
FcγRIIa Enhances Thrombus Growth in Vitro and in Vivo (2011) (1)
A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia (2016) (1)
Von Willebrand Factor Facilitates Intravascular Dissemination of Microsporidia Encephalitozoon hellem (2021) (1)
Heparin-Induced Thrombocytopenia Antibodies Inhibit PF4-Dependent Enhancement of Activated Protein C Formation by Binding to Antigenic Complexes Formed with the Chondroitin Sulfate Side-Chain of Thrombomodulin (2010) (1)
Expression of Urokinase-Type Plasminogen Activator in Platelets Decreases Oxygen-Induced Lung Injury in Mice. (2004) (1)
“Leucine Sensitive Hypoglycemia” Caused by a Dominantly-inherited Mutation of Glutamate Dehydrogenase • 442 (1998) (1)
The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis (2015) (1)
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts (2022) (1)
Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models. (2012) (1)
Relative contribution of STIM1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis (2011) (1)
Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction (2010) (1)
Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation (2016) (1)
essential for expression of this TATA-less gene specific alpha IIb gene appears to stabilize Sp1 binding and is An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte- (2011) (0)
thrombocytopenia pathogenesis: diagnostic and therapeutic implications Role of platelet surface PF4 antigenic complexes in heparin-induced (2013) (0)
growth and polyploidization Cdk4 is regulated by GATA-1 and required for megakaryocyte - Cyclin D (2013) (0)
FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT (2014) (0)
A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT) (2015) (0)
Pigment Cells Mechanisms of Protein Delivery to Melanosomes in (2015) (0)
Neutrophil extracellular trap stabilization leads to improved outcomes in murine models of sepsis (2019) (0)
SLFN14 ribosomopathy and platelet dysfunction. (2023) (0)
Strategies to Enhance the Efficacy of Platelet-Derived Factor (F) VIII: Studies with Inactivation Resistant FVIII (IR8) and Canine FVIII in Hemophilia A Mice. (2009) (0)
Fusion of uPA to Anti-aIIbb3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis (2022) (0)
Cyclin D/CDK4/6 kinase activity, regulated by GATA1, is required for megakaryocyte polyploidization (2007) (0)
Effect of folic and folinic acid on serum and CSF folate levels in congenital folate malabsorption. (1980) (0)
Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT) (2012) (0)
Conditional Knockout of LRP1 in Murine Megakaryocytes and Its Affects on Platelet Factor 4 Biology in Megakaryocytes (2014) (0)
Molecular biology studies with primary megakaryocytes. (1999) (0)
Cyclin D: CDK4/6 Kinase Activity, Regulated by GATA-1, Is Required for Megakaryocyte Polyploidization. (2006) (0)
human erythroleukemic cell line Cloning and characterization of platelet factor 4 cDNA derived from a (2010) (0)
Platelet-Delivered Factor VIII (FVIII) Decreases Thrombus Stability. (2006) (0)
Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs) (2012) (0)
Platelet Factor 4 (PF4) Levels Are Inversely Correlated with Steady-State Platelet Counts and with Nadir Counts in Chemotherapy-Induced Thrombocytopenia (CIT), (2011) (0)
Murine (m) alphaIIbeta out-competes human (h) alphaIIb for mouse beta3 in a transgenic mouse model: Implications for integrin subunit interactions (2003) (0)
PLATELETS AND THROMBOPOIESIS Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia (2016) (0)
Title: Signaling through Fc g RIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 One-sentence summary: The Fc g RIIA and C5a-C5aR pathways mediate platelet hyperactivation in COVID-19 (2021) (0)
Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. (2022) (0)
The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis (2015) (0)
FDG-PET IMAGING OF CLOTS: NEW ANIMAL MODEL BASED UPON THE FERRIC CHLORIDE INJURY MODEL (2005) (0)
A naturally occurring mutation near the amino terminus of a IIb deﬁnes a new region involved in ligand binding to a IIb b 3 (1999) (0)
RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction (2020) (0)
RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation (2012) (0)
Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules (2021) (0)
Comment on Nagy et al , page 331 Gp 1 baCre or Pf 4-Cre : pick your poison (2019) (0)
Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT) (2012) (0)
A(nother) day in the life of neonatal platelets. (2014) (0)
Enhancing Functional Platelet Release In Vivo from in Vitro-Grown Megakaryocytes Using the Protein Kinase Inhibitor SU6656 (2016) (0)
Negative Paracrine Effect of Platelet Factor 4 on Megakaryopoiesis Occurs through Lipoprotein Related Protein Receptor-1 on Megakaryocytes. (2007) (0)
A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice (2018) (0)
demonstrate identity with the native protein Biologic and biochemic properties of recombinant platelet factor 4 (2011) (0)
Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells (2014) (0)
Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy (2010) (0)
In Situ Microscopy Studies of Infused Megakaryocytes: Implications in Thrombopoiesis (2021) (0)
The Signaling Molecule CalDAG-GEFI Represents a Novel Target for Antithrombotic Therapy. (2009) (0)
Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis (2022) (0)
Intrinsic Deficiency of PAI-1 in Human Pulmonary Arterial Smooth Muscle Cells From Pulmonary Artery Hypertension (PAH) Patients Drives UPA-dependent Cell Proliferation and Induces Spontaneous Pulmonary Hypertension in Mice (2023) (0)
Towards the Care of Hemophilia a Patients Using Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Expressing Coagulation Factor (F) VIII (2015) (0)
CDNA AND GENOMIC CLONES FOR HUMAN PLATELET GLYCOPROTEIN lib (GPIIb) (1987) (0)
in platelet activation γ and PI3K β The relative role of PLC (2013) (0)
Nanogel Drug Carriers Presenting Platelet GPIbα Mimic and Enhance Platelet Adhesion (2016) (0)
The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression. (2008) (0)
Endogenous Platelet PF4 Promotes In Vivo Activated Protein C (APC) Generation and Survival after Lethal Lipopolysaccharide Challenge in Mice: A Potential Physiologic Role for PF4. (2005) (0)
Factor (F) VIII Is Stored in Platelets Independent of Von Willebrand Factor (VWF). (2004) (0)
The Influence of FLI1 Expression Levels on Megakaryopoiesis: Studies Using iPSCs (2015) (0)
S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes (2023) (0)
THROMBOSIS AND HEMOSTASIS Cooperative integrin / ITAM signaling in platelets enhances thrombus formation in vitro and in vivo (2013) (0)
Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia (2010) (0)
Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice (2013) (0)
Inherited Thrombocytopenias (2019) (0)
Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis (2019) (0)
necessary for consistent, high-level megakaryocyte expression IIb gene locus α Identification of distal regulatory regions in the human (2013) (0)
Platelet Factor 4 (PF4) Antigenic Complexes on the Macrophage Surface: Implications for the Pathogenesis of Heparin Induced Thrombocytopenia (HIT). (2006) (0)
Comparative Analysis of Infused “Static”, Ex Vivo-Generated Platelets Vs. Infused Megakaryocytes-Generated Platelets: A Cautionary Tale (2014) (0)
Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia (2015) (0)
Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia (2015) (0)
thrombi in mice: implications for antiplatelet therapy 3 activation determines the size and stability of β (2013) (0)
Utilizing CRISPR-CAS9 Gene Editing Technology in Human Pluripotent Stem Cells to Study Platelet Integrin αIIbβ3 Function (2020) (0)
Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis (2020) (0)
Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides. (2005) (0)
Platelet Factor 4 Regulates Platelet Count In Vivo: Implications for Platelet Recovery after Cytotoxic Therapy. (2005) (0)
Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges (2018) (0)
conserved domains and alternative proteolytic processing Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily (2011) (0)
New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation (2014) (0)
Polymerase chain reaction (PCR) for detection of PstI polymorphism in the human PF4 gene. (1990) (0)
852 THROMBOCYTOSIS IN PATIENTS WITH SICKLE CELL ANEMIA AND PNEUMONIA (1981) (0)
Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3 (2011) (0)
THROMBOSIS AND HEMOSTASIS The disul fi de isomerase ERp 72 supports arterial thrombosis in mice (2017) (0)
Exploiting Induced Pluripotent Stem Cells to Unravel Mechanisms in Inherited Platelet/Megakaryocyte Disorders (2020) (0)
Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment (2016) (0)
Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells (2014) (0)
Release of High Levels of Platelet Factor 4 (PF4) from Platelets Improves Survival after a Lethal Lipopolysaccharide (LPS) Challenge. (2006) (0)
Complement Regulates the Procoagulant Effects of HIT Immune Complexes (2020) (0)
PLATELETS AND THROMBOPOIESIS CRISPR / Cas 9-mediated conversion of human platelet alloantigen allotypes (2016) (0)
Platelet Release from Infused CD34+-Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor (2016) (0)
Platelet Factor 4 (PF4) Causes Cell Cycle Arrest in Megakaryocytes (Megs) by Inactivating CDC2 (CDK1) and CDK2 (2012) (0)
A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis (2019) (0)
THROMBOSIS AND HEMOSTASIS Platelet-delivered ADAMTS 13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models (2015) (0)
cell surface endocytic itinerary, resulting in retention of low-density lipoprotein on the Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the (2013) (0)
Expansion of Platelets for Transfusion (2010) (0)
A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis (2014) (0)
Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy (2016) (0)
Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity (2015) (0)
RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects: Therapeutic implications (2022) (0)
Structure-guided design of a pure orthosteric antagonist of integrin αlIbβ3 that inhibits thrombosis but not clot retraction (2018) (0)
ACUTE CHEST SYNDROME (ACS) IN SICKLE CELL PATIENTS IS OFTEN DUE TO MYCOPLASMA PNEUMONIAE (1984) (0)
Species differences in small molecule binding to (cid:1) IIb (cid:2) 3 are the result of sequence differences in 2 loops of the (cid:1) IIb (cid:2) propeller (2009) (0)
Platelet Factor VIII-Induced Megakaryocyte Apoptosis: Implications for Hemophilia A Gene Therapy (2012) (0)
Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia (2018) (0)
Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT) (2013) (0)
Corrigenda (2006) (0)
The GATA-1/FOG-1/NuRD Axis Is Essential for Normal Hematopoiesis. (2007) (0)
Demonstration that platelet-expressed human B-domainless Factor VIII can ameliorate the bleeding diathesis in a murine model of hemophilia A (2003) (0)
Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs (2022) (0)
Peroxisome Proliferator-Activated Receptor gamma (PPARγ) Regulates CD36 Gene Expression in Megakaryocytic Cell Lines. (2006) (0)
of heparin-induced thrombocytopenia Ultralarge complexes of PF4 and heparin are central to the pathogenesis (2010) (0)
inactivation (see comments) unrelated males based on studies of maternal T cell X chromosome Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two (2011) (0)
activation Structural requirements of platelet chemokines for neutrophil (2011) (0)
antibodies using KKO, a murine HIT-like monoclonal antibody Defining a second epitope for heparin-induced thrombocytopenia/thrombosis (2013) (0)
Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic? (2022) (0)
Journal of Bone Marrow Research (0)
Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis (2013) (0)
The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction (2019) (0)
Histones, Like Platelet Factor 4 (PF4), Affect Generation of Activated Protein C: Implications for the Pathogenesis of Severe Sepsis (2011) (0)
A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis (2019) (0)
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury (2023) (0)
Polyreactive IgM initiates complement activation by PF 4 / heparin complexes through the classical pathway Running Title : IgM involvement in the HIT Immune Response (2018) (0)

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