Muhammad Akhtar
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(Suggest an Edit or Addition)According to Wikipedia, Muhammad Akhtar FRS is a British-Pakistani biochemist, and former Director General of the School of Biological Sciences, at the University of the Punjab. Biography He spent the years 1959 to 1963 doing science research in Cambridge, Massachusetts before moving to the University of Southampton, UK as a lecturer, then reader and then Professor of Biochemistry . From 1978 until 1991 he was head of the Department of Biochemistry. He was chairman of the School of Biochemical and Physiological Sciences from 1983 to 1987 and chairman of the Institute of Biomolecular Sciences from 1989 to 1991. He was a founding fellow of the Third World Academy of Sciences in 1984 and a director of the SERC Centre for Molecular Recognition from 1990-1994.
Muhammad Akhtar 's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanistic studies on aromatase and related CC bond cleaving P-450 enzymes (1993) (124)
- Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: studies on cytochrome P-450(17)alpha. (1994) (96)
- A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17) (2011) (93)
- Reactions at Position 19 in the Steroid Nucleus. A Convenient Synthesis of 19-Norsteroids (1964) (92)
- Studies on vision. The nature of the retinal-opsin linkage. (1968) (88)
- Anaerobic and aerobic coproporphyrinogen III oxidases of Rhodopseudomonas spheroides. Mechanism and stereochemistry of vinyl group formation. (1983) (68)
- The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis. (1969) (66)
- A unified mechanistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzymes. (1991) (66)
- Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives. (1978) (62)
- Mechanistic consideration of P-450 dependent enzymic reactions: studies on oestriol biosynthesis (1988) (60)
- The mechanism of action of serine transhydroxymethylase. (1970) (60)
- Mechanism and stereochemistry of the 5-aminolaevulinate synthetase reaction. (1973) (59)
- Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments. (1989) (56)
- The intermediary role of a 19-oxoandrogen in the biosynthesis of oestrogen. (1968) (55)
- Cooperativity during multiple phosphorylations catalyzed by rhodopsin kinase: supporting evidence using synthetic phosphopeptides. (1993) (53)
- The removal of the 32-carbon atom as formic acid in cholesterol biosynthesis (1972) (51)
- The reduction of a rhodopsin derivative. (1965) (47)
- Studies on the removal of C-19 in oesterogen biosynthesis using 18O2 (1976) (46)
- Mechanism of rhodopsin kinase regulation by recoverin (2009) (46)
- Biosynthesis of 5-aminolevulinic acid: involvement of a retention–inversion mechanism (1974) (45)
- Studies on estrogen biosynthesis using radioactive and stable isotopes (1990) (44)
- Stereospecificity of oxidation at C-19 in oestrogen biosynthesis (1975) (40)
- Some Radical Exchange Reactions during Nitrite Ester Photolysis1 (1965) (39)
- Functional rhodopsin complex consisting of three noncovalently linked fragments. (1977) (37)
- The preparation of chloromethylketone analogues of amino acids: inhibition of leucine aminopeptidase. (1972) (37)
- The pathway for the removal of the 15α-methyl group of lanosterol: The role of Lanost-8-ene-3β,32-diol in cholesterol biosynthesis (1977) (37)
- Incorporation of label from 18O2 into acetate during side-chain cleavage catalysed by cytochrome P-45017α(17α-hydroxylase-17,20-lyase) (1994) (36)
- Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin. (1992) (35)
- The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b 5-dependent acyl-carbon cleavage activities (2004) (34)
- An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17). (1998) (34)
- THE PHOTOCHEMICAL REARRANGEMENT OF HYPOCHLORITES (1961) (33)
- Steroidal C-19 sulphur and nitrogen derivatives designed as aromatase inhibitors (1985) (32)
- Topography of the rhodopsin molecule. Identification of the domain phosphorylated. (1978) (30)
- The transfer of hydrogen from C-24 to C-25 in ergosterol biosynthesis. (1967) (29)
- The active site of the visual protein, rhodopsin (1967) (29)
- The role of a cholesta-8,14-dien-3β-ol system in cholesterol biosynthesis (1969) (28)
- Recoverin inhibits the phosphorylation of dark-adapted rhodopsin more than it does that of bleached rhodopsin: a possible mechanism through which rhodopsin kinase is prevented from participation in a side reaction. (1997) (27)
- The formation and reduction of the 14,15-double bond in cholesterol biosynthesis. (1971) (27)
- The Synthesis of Substituted Aldosterone (1963) (26)
- Interaction of a conformationally rigid analogue of retinal with bacterio-opsin (1982) (26)
- The modification of acetate and propionate side chains during the biosynthesis of haem and chlorophylls: mechanistic and stereochemical studies. (1994) (26)
- Stereochemistry of porphyrinogen carboxy-lyase reaction in haem biosynthesis (1975) (25)
- A Convenient Synthesis of 19-Norsteroids (1962) (25)
- The mechanism of cytochrome P-450 dependent C–C bond cleavage: studies on 17α-hydroxylase-17,20-lyase (1991) (25)
- Mechanism and stereochemistry of enzymic reactions involved in porphyrin biosynthesis. (1976) (25)
- A chiral synthesis of D-(+)-2,6-dideoxystreptamine and its microbial incorporation into novel antibiotics. (1976) (24)
- Mechanism and stereochemistry of the porphobilinogen deaminase and protoporphyrinogen IX oxidase reactions: stereospecific manipulation of hydrogen atoms at the four methylene bridges during the biosynthesis of haem. (1984) (24)
- The phospho-opsin phosphatase from bovine rod outer segments. An insight into the mechanism of stimulation of type-2A protein phosphatase activity by protamine. (1994) (24)
- The reversibility of the Δ8-cholestenol–Δ7-cholestenol isomerase reaction in cholesterol biosynthesis (1969) (21)
- The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis. (1970) (21)
- The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis. (1969) (20)
- A convenient synthesis of labelled rhodopsin and studies on its active site. (1970) (19)
- The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol. (1967) (19)
- Mechanism and stereochemistry of vinyl-group formation in haem biosynthesis. (1976) (19)
- Silver-Catalyzed Decomposition of Hypobromites (1965) (19)
- Chemistry of the active site of rhodopsin. (1969) (19)
- Rhodopsin kinase: studies on the sequence of and the recognition motif for multiphosphorylations. (1994) (18)
- Chapter 2 Mechanism and stereochemistry of the enzymes involved in the conversion of uroporphyrinogen III into haem (1991) (18)
- Stereochemistry of hydrogen elimination in the enzymic formation of the C-2–C-3 double bond of porphobilinogen (1976) (18)
- On the disulphide bonds of rhodopsins. (1987) (18)
- Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1. (2015) (18)
- Obtaining and characterization of EF‐hand mutants of recoverin (1998) (17)
- The synthesis of labelled 24-methylenelanosterol and its conversion into ergosterol. (1966) (17)
- The co-ordinated inhibition of protein and lipid biosynthesis by adenosine 3':5'-cyclic monophosphate. (1970) (17)
- Studies on the biosynthesis of the ergosterol side chain. (1969) (16)
- Radical Exchange during Nitrite Photolysis (1964) (16)
- The regeneration of rhodopsin from all-trans-retinal: solubilization of an enzyme system involved in the completion of the visual cycle. (1972) (16)
- Phosphorylatio of solubilised dark‐adapted rhodopsin (1993) (16)
- The intermediary role of a steroid 8,14-dien-3-beta-ol system in ergosterol biosynthesis. (1969) (16)
- Synthesis of 19-functionalised derivatives of 16α-hydroxy-testosterone: mechanistic studies on oestriol biosynthesis (1985) (15)
- Inhibition of aromatase by steroids substituted at C-19 with halogen, sulphur, and nitrogen (1989) (15)
- Novel mechanism for the activation of rhodopsin kinase: implications for other G protein-coupled receptor kinases (GRK's). (1996) (15)
- The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol. (1971) (15)
- Structural studies on membrane-bound bovine rhodopsin. (1983) (15)
- Substrate activation in pyridine nucleotide-linked reactions: illustrations from the steroid field (1972) (15)
- The pathway for the removal of C-32 in cholesterol biosynthesis (1971) (15)
- Studies on a missing reaction in the visual cycle. (1972) (15)
- Mechanism and sterochemistry of vinyl group formation in haem biosynthesis (1972) (15)
- Mechanistic studies on the phytylation and methylation steps in bacteriochlorophyll a biosynthesis: an application of the oxygen-18-induced isotope effect in carbon-13 NMR (1987) (15)
- The introduction of the C-22-C-23 ethylenic linkage in ergosterol biosynthesis. (1968) (14)
- Studies on the regeneration of rhodopsin from all-trans-retinal in isolated rat retinae. (1973) (14)
- Stereospecific synthesis of α-aminoacyl aldehydes and their interaction with α-chymotrypsin (1980) (14)
- 'Slow-binding' sixth-ligand inhibitors of cytochrome P-450 aromatase. Studies with 19-thiomethyl- and 19-azido-androstenedione. (1991) (14)
- An anti-anabolic role of adenosine 3',5'-cyclic monophosphate in the control of liver metabolism. a hypothetical mechanism for gluconeogenesis☆ (1972) (13)
- The formation of an 8,14-diene system during cholesterol biosynthesis (1969) (13)
- Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. (1971) (13)
- Rhodopsin phosphorylation in bovine rod outer segments is more sensitive to the inhibitory action of recoverin at the low rhodopsin bleaching than it is at the high bleaching (1997) (12)
- The conversion of 7-dehydrocholesterol into cholesterol. (1966) (12)
- The mechanism of the elaboration of ring B in ergosterol biosynthesis. (1968) (12)
- Enhancement of the anti-anabolic response to adenosine 3':5'-cyclic monophosphate during development. The inhibition of hepatic protein synthesis. (1977) (12)
- Stereospecific synthesis of chiral acetic acid from glycine (1978) (12)
- The mechanism of the action of δ-aminolaevulate synthetase and the synthesis of stereospecifically tritiated glycine (1968) (12)
- Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis. (1974) (12)
- The asymmetric distribution of enzymic activity between the six subunits of bovine liver glutamate dehydrogenase. Use of D- and L-glutamyl alpha-chloromethyl ketones (4-amino-6-chloro-5-oxohexanoic acid. (1976) (12)
- Inactivation of serine transhydroxymethylase and threonine aldolase activities. (1972) (11)
- The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol. (1966) (11)
- The involvement of an O2-derived nucleophilic species in acyl–carbon cleavage, catalysed by cytochrome P-45017α: implications for related P-450 catalysed fragmentation reactions (1994) (11)
- A Proton‐Magnetic‐Resonance Study of N‐Trifluoroacetyl‐l‐alanyl‐l‐phenylalaninal Binding to α‐Chymotrypsin (1980) (10)
- Synthesis of a medium-size ring via alkoxy radical decomposition (1966) (10)
- Mechanism of the formation of the two epimeric diamino-hexose rings of neomycin B (1986) (9)
- 814. Carotenoids and related compounds. Part VIII. Novel syntheses of echinenone and canthaxanthin (1959) (9)
- A CONVENIENT SYNTHESIS OF VITAMIN D3-9,19-3H AND THE MECHANISM OF THE PREVITAMIN D3-----VITAMIN D3 REACTION. (1965) (9)
- The removal of the 14-methyl group in cholesterol biosynthesis (1968) (9)
- Mechanistic studies on the phytylation step in bacteriochlorophyll a biosynthesis: an application of the 18O induced isotope effect in 13C n.m.r. spectroscopy (1985) (8)
- The mechanism of the C-13(3) esterification step in the biosynthesis of bacteriochlorophyll a. (1985) (8)
- The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and beta-hydroxybutyrate dehydrogenase. (1975) (8)
- First efficient synthesis of α-MAPI (1998) (8)
- Function of the farnesyl moiety in visual signalling. (2000) (8)
- Identification of the active site polypeptide in labeled photoreceptor membranes digested with papain (1977) (8)
- A convenient synthesis of (9,19-3H2)cholecalciferol 3,5-dinitrobenzoate and the mechanism of the precholecalciferol to calciferol reaction. (1965) (7)
- The involvement of C-4 of D-glucose in the biosynthesis of the 2-deoxystreptamine ring of neomycin (1987) (7)
- The stereochemistry of hydrogen elimination during 7,8-double bond formation by Tetrahymena pyriformis. (1970) (7)
- Mechanism of reduction of double bonds in biological systems: conversion of desmosterol into cholesterol (1969) (6)
- Chromophore-environment interaction of visual pigments in model system. (1971) (6)
- Mechanistic studies on the biosynthesis of the 2-deoxystreptamine ring of neomycins (1983) (6)
- A novel method of solid phase peptide synthesis (1994) (6)
- Mechanism of C-2–C-3 bond formation and cleavage in serine transhydroxymethylase reactions (1976) (6)
- 190. Studies with acetylenes. Part III. The synthesis of three partly-cis-diphenyloctatetraenes (1959) (6)
- A transition from ionic to free-radical mechanisms in chemistry and enzymology (1994) (5)
- Stereochemistry of the generation of the ethyl group in bacteriochlorophyll a biosynthesis (1985) (5)
- The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis. (1969) (5)
- Mechanistic and stereochemical studies on 3-oxo steroid delta 4-delta 5-isomerase from human placenta. (1980) (5)
- The origin of the 14α-hydrogen in cholesterol biosynthesis (1969) (5)
- Mechanism and stereochemistry of the elaboration of the neosamine C ring in the biosynthesis of neomycins (1983) (4)
- The mechanism of C-4 demethylation during cholesterol biosynthesis. (1975) (4)
- The incorporation of tritiated retinyl moiety into the active-site lysine residue of bacteriorhodopsin. (1979) (4)
- Chapter 9 Pyridoxal phosphate-dependent enzymic reactions: mechanism and stereochemistry (1984) (4)
- The transfer of the double bond from 8(9) to 7(8) in cholesterol biosynthesis (1968) (4)
- Activation of rhodopsin kinase. (2002) (4)
- Phosphorylation of solubilised dark-adapted rhodopsin. Insights into the activation of rhodopsin kinase. (1993) (4)
- Labelling of amino-acid side-chains with 13C-labelled electrophiles; potential application to the probing of active sites of enzymes (1975) (4)
- Activation of rhodopsin kinase (2002) (4)
- Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin. (1993) (4)
- The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. (1969) (4)
- Stereochemistry of the glycine reductase of Clostridium sticklandii (1975) (3)
- Structure and conformation of rhodopsin in the disc membrane. (1983) (3)
- The biochemical role of vitamin B12. (1969) (3)
- The mechanism of the alkylation step in ergosterol biosynthesis (1966) (3)
- Mitochondrial effects of cyclic AMP: A possible mechanism for steroidogenesis (1970) (2)
- Synthesis of a medium-size carbocyclic system (1964) (2)
- Carotenoids and related compounds. Part 35. Synthesis of (±)-azafrin methyl ester and other α-glycols (1978) (2)
- The conversion of steroid 7,9-dienes into cholesterol. (1969) (2)
- SYNTHESIS OF 19-FUNCTIONALIZED DERIVATIVES OF 16α-HYDROXYTESTOSTERONE: MECHANISTIC STUDIES ON ESTRIOL BIOSYNTHESIS (1985) (1)
- A CHIRAL SYNTHESIS OF D-(+)-2,6-DIDEOXYSTREPTAMINE AND ITS MICROBIAL INCORPORATION INTO NOVEL ANTIBIOTICS (1977) (1)
- The synthesis and use of oligodeoxynucleotides in plasmid DNA sequencing. (1986) (1)
- Chapter 3. Reaction mechanisms. Part (iii) Enzyme mechanisms (1971) (1)
- INTERACTION OF A CONFORMATIONALLY RIGID ANALOG OF RETINAL WITH BACTERIOOPSIN (1982) (1)
- Studies ontheBiosynthesis oftheErgosterol SideChain (1969) (1)
- The role of adenosine 3':5'-cyclic monophosphate in the growth and development of rat liver. (1976) (1)
- The incorporation of a 15β-hydrogen atom from the medium in cholesterol biosynthesis (1969) (1)
- A proton-magnetic-resonance study of N-trifluoroacetyl-L-alanyl-L-phenylalaninal binding to alpha-chymotrypsin. (1980) (1)
- FIRST EFFICIENT SYNTHESIS OF ALPHA -MAPI (1998) (1)
- Isomerization of all-trans-Retinal to 11-cis-Retinal in Isolated Frog Retinae (1973) (1)
- Isolation and properties of protein phosphatase type 2A in photoreceptors. (2000) (1)
- A Convenient Synthesis ofLabelled Rhodopsin andStudies onits Active Site (1970) (0)
- First Efficient Synthesis of α‐MAPI. (1998) (0)
- Steroidal C-19 Sulphur and Nitrogen Derivatives Designed as Aromatase Inhibitors. (1986) (0)
- How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins? (1996) (0)
- Glycidaldehyde, an Inhibitor Directed towards the C1-Unit-Binding Site of Serine Transhydroxymethylase (1973) (0)
- TheStereospecific RemovalofaC-19Hydrogen Atomin Oestrogen Biosynthesis (1969) (0)
- Studies on the mechanism of action of pepsin (1969) (0)
- Chapter 18. Enzyme mechanisms (1970) (0)
- TheIntermediary RoleofaSteroid 8,14-Dien-3p-ol Systemin Ergosterol Biosynthesis (1969) (0)
- Synthesis of rings A and B of strophanthidin (1965) (0)
- The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. (1969) (0)
- Mechanism of the Formation of the Two Epimeric Diamino-hexose Rings of Neomycin B. (1986) (0)
- The labelling of a catalytic group of pepsin; evidence for an acyl intermediate (1969) (0)
- CAROTENOIDS AND RELATED COMPOUNDS. PART 35. SYNTHESIS OF (.+-.)-AZAFRIN METHYL ESTER AND OTHER α-GLYCOLS (1979) (0)
- A review of 18O labelling Studies to probe the mechanism of aromatase (CYP191A) (2021) (0)
- Studies on the mechanism of action of pepsin: a caution (1970) (0)
- Biosynthesis (Volume 1) (1973) (0)
- Design and synthesis of novel Src homology-2 domain inhibitors (1999) (0)
- New methods in solid phase peptide synthesis (1995) (0)
- Glycidaldehyde , an Inhibitor Directed towards the C ,-Unit-Binding Site of Serine (0)
- Mechanism of the phytylation step in bacteriochlorophyll a biosynthesis (1980) (0)
- The nature of the retinaldehyde-opsin linkage. (1969) (0)
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