Nicholas Francis Larusso

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Biology

Nicholas Francis Larusso's Degrees

PhD Biomedical Sciences University of California, San Francisco
Bachelors Biology Stanford University

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Nicholas Francis Larusso's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs (2015) (1299)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. (2000) (656)
Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis (1989) (588)
Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. (1996) (514)
Biliary tract cancers. (1999) (486)
A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection* (2007) (442)
Clinicopathologic features of the syndrome of primary sclerosing cholangitis (1980) (389)
The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis (2000) (371)
A revised natural history model for primary sclerosing cholangitis. (1997) (349)
The cholangiopathies: disorders of biliary epithelia. (2004) (341)
Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. (1991) (334)
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. (2003) (308)
Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease. (2010) (306)
Primary sclerosing cholangitis: findings on cholangiography and pancreatography. (1983) (301)
The Value of Serum CA 19-9 in Predicting Cholangiocarcinomas in Patients with Primary Sclerosing Cholangitis (2005) (301)
Long‐term results of patients undergoing liver transplantation for primary sclerosing cholangitis (1999) (297)
Recurrence of primary sclerosing cholangitis following liver transplantation (1999) (296)
Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis (1981) (290)
Characterization of PKD protein-positive exosome-like vesicles. (2009) (287)
Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. (2001) (287)
The pathobiology of biliary epithelia (2002) (285)
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (2007) (281)
MicroRNA‐21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3 (2009) (273)
Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. (2006) (267)
The isolated perfused rat liver: Conceptual and practical considerations (1986) (264)
Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations. (1985) (249)
Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. (2010) (248)
Primary sclerosing cholangitis: refinement and validation of survival models. (1992) (248)
Primary sclerosing cholangitis: Summary of a workshop (2006) (247)
Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. (1997) (233)
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. (1996) (224)
Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. (2013) (213)
High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis (2000) (211)
The Pathophysiology of Biliary Epithelia (2004) (211)
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. (2001) (209)
Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. (1989) (209)
Cholangiocyte pathobiology (2019) (207)
An aged immune system drives senescence and ageing of solid organs (2021) (207)
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. (2001) (205)
Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB1 (2005) (201)
Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. (1974) (198)
Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. (2003) (192)
Up‐regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis (2012) (192)
MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes12 (2009) (191)
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion (2007) (190)
The Water Channel Aquaporin-8 Is Mainly Intracellular in Rat Hepatocytes, and Its Plasma Membrane Insertion Is Stimulated by Cyclic AMP* (2001) (189)
Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. (2001) (188)
Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis. (1993) (184)
Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. (1984) (184)
Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. (1985) (183)
Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane (1997) (182)
Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. (1985) (180)
Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion. (1987) (177)
Primary sclerosing cholangitis. (1984) (177)
Cholangiocyte senescence by way of N‐ras activation is a characteristic of primary sclerosing cholangitis (2014) (177)
Recent advances in the isolation of liver cells (1994) (174)
Gallbladder disease in patients with primary sclerosing cholangitis. (1988) (173)
HDAC6 inhibition restores ciliary expression and decreases tumor growth. (2013) (172)
Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis (2016) (170)
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. (2008) (164)
Physiology of cholangiocytes. (2013) (164)
Extracellular vesicles in liver pathobiology: Small particles with big impact (2016) (156)
Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis. (2000) (155)
Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients. (1975) (154)
Prospective trial of penicillamine in primary sclerosing cholangitis. (1988) (154)
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense (2013) (153)
Clinicopathologic features of the syndrome of primary sclerosing cholangitis. (1980) (152)
Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. (1988) (151)
Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism. (1992) (150)
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. (2008) (147)
Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis (1992) (142)
Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. (1996) (140)
Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. (2001) (140)
Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. (1997) (140)
Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. (1994) (140)
Effect of proctocolectomy for chronic ulcerative colitis on the natural history of primary sclerosing cholangitis. (1989) (136)
Cholangiocyte primary cilia in liver health and disease (2008) (136)
Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis. (1986) (132)
Cholelitholysis using methyl tertiary butyl ether. (1985) (130)
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. (2007) (130)
Efficacy and Safety of Transarterial Radioembolization Versus Chemoembolization in Patients With Hepatocellular Carcinoma (2013) (130)
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. (1998) (128)
Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. (2000) (128)
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. (2007) (127)
The Cholangiopathies. (2015) (127)
Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. (1999) (127)
Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease. (1990) (125)
Elevated Circulating Immune Complexes in Primary Sclerosing Cholangitis (2007) (125)
The relative role of the child‐pugh classification and the mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis (1999) (125)
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. (2003) (124)
Bcl‐2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line (1997) (124)
The dynamic biliary epithelia: molecules, pathways, and disease. (2013) (123)
Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. (1977) (123)
The combination of prednisone and colchicine in patients with primary sclerosing cholangitis. (1991) (121)
Water transport by epithelia of the digestive tract. (2002) (120)
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD) (2009) (119)
Somatostatin analog therapy for severe polycystic liver disease: results after 2 years. (2012) (119)
Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload. (1989) (118)
Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes* (2003) (118)
The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population. (2007) (114)
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. (1994) (113)
Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. (2013) (112)
Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases (2013) (111)
Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma (2006) (111)
Manifestations of nonsuppurative cholangitis in chronic hepatobiliary diseases: morphologic spectrum, clinical correlations and terminology. (2008) (110)
Primary Sclerosing Cholangitis (1984) (110)
Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. (1998) (110)
Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects. (1975) (110)
Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells. (2000) (109)
Expression and Localization of Aquaporin Water Channels in Rat Hepatocytes (2002) (107)
Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. (1983) (106)
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. (2004) (106)
Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application (1980) (105)
A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. (2007) (104)
NFκB p50-CCAAT/Enhancer-binding Protein β (C/EBPβ)-mediated Transcriptional Repression of MicroRNA let-7i following Microbial Infection* (2009) (104)
Apolipoproteins of high, low, and very low density lipoproteins in human bile. (1983) (104)
Primary sclerosing cholangitis and celiac disease. A novel association. (1988) (102)
The metabolic bone disease of primary sclerosing cholangitis (1991) (102)
Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. (1991) (97)
Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer? (1997) (97)
Isolation and characterization of cholangiocyte primary cilia. (2006) (96)
In primary sclerosing cholangitis, gallbladder polyps are frequently malignant (2002) (96)
MicroRNAs: key modulators of posttranscriptional gene expression. (2009) (95)
Interaction of metronidazole with nucleic acids in vitro. (1977) (94)
Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. (1995) (94)
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism (1998) (93)
Proteolytic Cleavage and Nuclear Translocation of Fibrocystin Is Regulated by Intracellular Ca2+ and Activation of Protein Kinase C* (2006) (92)
Nonoperative dilatation of dominant strictures in primary sclerosing cholangitis. (1985) (92)
Cholangiocarcinoma complicating primary sclerosing cholangitis: cholangiographic appearances. (1985) (91)
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. (2006) (90)
Proteins in bile: how they get there and what they do. (1984) (89)
Coordinate secretion of acid hydrolases in rat bile. (1979) (89)
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. (2010) (89)
Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study. (1996) (88)
Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. (2001) (88)
Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload. (1986) (86)
Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion. (2005) (86)
Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. (1999) (85)
Primary sclerosing cholangitis with normal serum alkaline phosphatase activity. (1988) (85)
Cholangiociliopathies: genetics, molecular mechanisms and potential therapies (2009) (84)
T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. (2006) (84)
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. (2018) (84)
Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. (1975) (83)
Performance of magnetic resonance elastography in primary sclerosing cholangitis (2016) (78)
Polycystic liver diseases: advanced insights into the molecular mechanisms (2014) (78)
Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes (2006) (78)
Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion (2004) (77)
Abnormalities in tests of copper metabolism in primary sclerosing cholangitis. (1985) (77)
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. (2003) (77)
Glucagon induces the plasma membrane insertion of functional aquaporin‐8 water channels in isolated rat hepatocytes (2003) (77)
Intrahepatic cholangiectases and large‐duct obliteration in primary sclerosing cholangitis (1986) (77)
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. (2008) (76)
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging (2018) (75)
Stimulation of ATP secretion in the liver by therapeutic bile acids. (2001) (74)
Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5‐trisphosphate receptor isoforms (2002) (74)
Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. (1997) (73)
Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning (2020) (73)
Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. (1995) (73)
Primary sclerosing cholangitis: value of cholangiography in determining the prognosis. (1991) (73)
Anatomy of the human biliary system studied by quantitative computer‐aided three‐dimensional imaging techniques (1998) (73)
A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis (2020) (72)
Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts. (1993) (72)
Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis (2014) (72)
The immunobiology of cholangiocytes (2008) (72)
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. (2003) (71)
CRYPTOSPORIDIUM PARVUM ATTACHMENT TO AND INTERNALIZATION BY HUMAN BILIARY EPITHELIA IN VITRO: A MORPHOLOGIC STUDY (2004) (71)
Interactions between chronic liver disease and inflammatory bowel disease. (1997) (70)
In primary sclerosing cholangitis, gallbladder polyps are frequently malignant. (2002) (70)
Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid. (1978) (69)
Phosphatidylinositol 3-Kinase and Frabin Mediate Cryptosporidium parvum Cellular Invasion via Activation of Cdc42* (2004) (69)
Abnormalities of chemical tests for copper metabolism in chronic active liver disease: differentiation from Wilson's disease. (1976) (67)
Cholangiocyte N-Ras Protein Mediates Lipopolysaccharide-induced Interleukin 6 Secretion and Proliferation* (2011) (67)
Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. (1993) (67)
Rat hepatocyte aquaporin‐8 water channels are down‐regulated in extrahepatic cholestasis (2003) (66)
Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. (2010) (65)
Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice (2018) (65)
Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains. (1995) (65)
Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: ileal pouch-anal anastomosis versus Brooke ileostomy. (1996) (64)
Biliary proteins: assessment of quantitative techniques and comparison in gallstone and nongallstone subjects. (1988) (64)
Cholangiocarcinomas express fas ligand and disable the fas receptor (1999) (63)
Water Transporting Properties of Hepatocyte Basolateral and Canalicular Plasma Membrane Domains* (2003) (63)
Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. (1997) (63)
Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy. (2002) (63)
Current concepts. Primary sclerosing cholangitis. (1994) (61)
Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin. (1993) (60)
ATP binding cassette transporter gene expression in rat liver progenitor cells (2003) (59)
Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography. (1984) (59)
Cholangiocarcinoma complicating primary sclerosing cholangitis. (1991) (59)
Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400412-JLR200 (2005) (58)
Specific Inhibition of AQP1 Water Channels in Isolated Rat Intrahepatic Bile Duct Units by Small Interfering RNAs* (2003) (58)
MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation (2018) (58)
Aquaporins in the hepatobiliary system (2006) (58)
Complications and risk factors after ileal pouch-anal anastomosis for ulcerative colitis associated with primary sclerosing cholangitis. (1993) (58)
Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. (2001) (58)
Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines (1998) (58)
Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs. (2011) (57)
Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. (2015) (57)
Enhanced autoreactivity of T‐lymphocytes in primary sclerosing cholangitis (1987) (57)
Cdc42 and the Actin-Related Protein/Neural Wiskott-Aldrich Syndrome Protein Network Mediate Cellular Invasion by Cryptosporidium parvum (2004) (56)
Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition. (1995) (55)
Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanism of hepatic extraction. (1986) (55)
Molecular studies of ceruloplasmin deficiency in Wilson's disease. (1987) (55)
Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis. (1989) (54)
Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis (2010) (54)
Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers. (1982) (54)
Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. (1997) (53)
Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases (2014) (53)
Milder disease stage in patients with primary biliary cholangitis over a 44‐year period: A changing natural history (2018) (52)
The syndrome of primary sclerosing cholangitis. (1990) (52)
Rat Hepatocytes Transport Water Mainly via a Non-channel-mediated Pathway (*) (1996) (51)
Aquaporin‐1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis (2010) (51)
Expression of aquaporin‐4 water channels in rat cholangiocytes (2000) (50)
Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation. (2003) (50)
MicroRNA (miR)‐433 and miR‐22 dysregulations induce histone‐deacetylase‐6 overexpression and ciliary loss in cholangiocarcinoma (2018) (49)
Diagnosis and treatment of primary sclerosing cholangitis. (1985) (49)
Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma. (2004) (49)
Oral Nicotine in Treatment of Primary Sclerosing Cholangitis (A Pilot Study) (2004) (49)
Development of an intravenous bile acid tolerance test. Plasma disappearance of cholylglycine in health. (1975) (48)
Determinants of fasting and postprandial serum bile acid levels in healthy man (1978) (47)
A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis (2000) (46)
Intrahepatic bile ducts transport water in response to absorbed glucose. (2002) (45)
Cryptosporidium parvum infects human cholangiocytes via sphingolipid‐enriched membrane microdomains (2006) (44)
Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. (2005) (43)
Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions. (2000) (42)
Development and characterization of a rodent model of immune-mediated cholangitis. (1996) (42)
Expression and Localization of Aquaporin Water Channels in Rat Hepatocytes EVIDENCE FOR A ROLE IN CANALICULAR BILE SECRETION* (2002) (42)
Advances in primary sclerosing cholangitis. (1990) (42)
Hemobilia: Etiology, diagnosis, and treatment☆. (2018) (42)
Circadian rhythms of biliary protein and lipid excretion in rats. (1990) (41)
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. (1998) (41)
HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis. (2014) (40)
Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease (2006) (40)
TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling (2017) (39)
Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. (2012) (39)
Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. (1990) (39)
Primary sclerosing cholangitis: a progressive disease? (1991) (39)
Primary sclerosing cholangitis. (1984) (38)
Rab3D, a small GTP–binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes (2000) (38)
Aquaporin water channels in liver: Their significance in bile formation (1997) (38)
Therapeutic Targets in Polycystic Liver Disease. (2017) (38)
If you feed them, they will come: A prospective study of the effects of complimentary food on attendance and physician attitudes at medical grand rounds at an academic medical center (2007) (38)
Strategies for improving attendance at medical grand rounds at an academic medical center. (2003) (37)
Solute and water transport pathways in cholangiocytes. (1996) (37)
Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry (1995) (37)
Time course of histological progression in primary sclerosing cholangitis (1999) (37)
Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr 2-/-mice (2017) (37)
Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer. (2013) (37)
Functional polarity of Na+/H+and Cl-/[Formula: see text]exchangers in a rat cholangiocyte cell line. (1998) (37)
Efficacy of 4 Years of Octreotide Long-Acting Release Therapy in Patients With Severe Polycystic Liver Disease. (2015) (37)
The Role of Cilia in the Regulation of Bile Flow (2011) (36)
HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum. (2009) (36)
Effect of chloroquine on the form and function of hepatocyte lysosomes. Morphologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. (1983) (36)
A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. (2000) (35)
Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II. (1998) (35)
Time course of histological progression in primary sclerosing cholangitis. (1999) (35)
Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. (1977) (35)
Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? (2017) (34)
Pathobiology of biliary epithelia and cholangiocarcinoma: Proceedings of the Henry M. and Lillian Stratton basic research single‐topic conference (2008) (34)
Hepatobiliary disease in inflammatory bowel disease. (1995) (34)
Functional polarity of Na+/H+ and Cl-/HCO3- exchangers in a rat cholangiocyte cell line. (1998) (33)
Polycystic liver disease: New insights into disease pathogenesis (2006) (33)
Cytoskeletal and motor proteins facilitate trafficking of AQP1‐containing vesicles in cholangiocytes (2006) (33)
Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes (2020) (33)
Cholangiocyte biology (2003) (32)
Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease. (2010) (32)
Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. (1990) (31)
Physicochemical determinants in hepatic extraction of small peptides (1990) (31)
Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma. (2017) (31)
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B (2005) (31)
TLR4 Promotes Cryptosporidium parvum Clearance in a Mouse Model of Biliary Cryptosporidiosis (2011) (31)
The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis (2019) (31)
Water movement across rat bile duct units is transcellular and channel‐mediated (2001) (31)
Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units. (2002) (30)
Epidermal Growth Factor Protects the Apical Junctional Complexes from Hydrogen peroxide in Bile Duct Epithelium (2010) (30)
Excellent long-term survival following liver transplantation in primary sclerosing cholangitis patients (1998) (30)
Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography (2013) (30)
Effect of litholytic bile acids on cholesterol absorption in gallstone patients. (1983) (30)
Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation (2020) (30)
Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target (2018) (29)
Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis (2017) (29)
The enteric microbiome in hepatobiliary health and disease (2016) (29)
Development and Characterization of Cholangioids from Normal and Diseased Human Cholangiocytes as an In Vitro Model to Study Primary Sclerosing Cholangitis (2017) (29)
Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application. (1980) (29)
AQP4 transfected into mouse cholangiocytes promotes water transport in biliary epithelia (2004) (28)
Hepatic processing of cholecystokinin peptides. II. Cellular metabolism, transport, and biliary excretion. (1986) (28)
The pathobiology of biliary epithelia. (2002) (28)
Polymicrobial cholangitis and Kaposi's sarcoma in blood product transfusion-related acquired immune deficiency syndrome. (1986) (28)
Cloning and expression of SLC10A4, a putative organic anion transport protein. (2006) (28)
Enzymatic Determination of Total 3α-Hydroxy Bile Acids in Faeces (1982) (28)
Effect of deoxycholic, chenodeoxycholic, and cholic acids on intestinal absorption of cholesterol in humans. (1982) (28)
Isolation of the microtubule-vesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids. (1995) (26)
Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis (2018) (26)
Morphology, Physiology, and Biochemistry of Biliary Epithelia (1996) (26)
Pathobiology of biliary epithelia (1994) (26)
Role for Krüppel-Like Transcription Factor 11 in Mesenchymal Cell Function and Fibrosis (2013) (26)
A Novel Incentive System for Faculty in an Academic Medical Center (2002) (25)
Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study (2019) (25)
MicroRNAs in Cholangiopathies (2014) (25)
The liver and intracellular digestion: How liver cells eat! (1989) (25)
GUDC inhibits cytochrome c release from human cholangiocyte mitochondria. (1999) (25)
Characterization of apical and basolateral plasma membrane domains derived from cultured rat cholangiocytes. (1997) (24)
Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. (1999) (24)
Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat. (1978) (24)
Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions (1998) (23)
IMMUNOHISTOLOGIC LABELING AS AN INDICATOR OF LIVER ALLOGRAFT REJECTION (1987) (23)
Microtubule modulation of biliary excretion of endogenous and exogenous hepatic lysosomal constituents. (1984) (23)
Validity of using 2,4-3H-labeled bile acids to study bile acid kinetics in man. (1974) (23)
Recent advances in the management of primary sclerosing cholangitis. (1987) (23)
MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment (2015) (23)
Effective dissolution of biliary duct stones by intraductal infusion of mono-octanoin (1978) (23)
Dissociation of bile flow and biliary lipid secretion from biliary lysosomal enzyme output in experimental cholestasis. (1981) (23)
MicroRNAs in cholangiociliopathies (2009) (23)
Lymphocyte subsets in primary sclerosing cholangitis (1987) (22)
Fluid-phase endocytosis by intrahepatic bile duct epithelial cells isolated from normal rat liver. (1990) (22)
Standardized care processes to improve quality and safety of patient care in a large academic practice: the Plummer Project of the Department of Medicine, Mayo Clinic (2008) (22)
TGR5 in the Cholangiociliopathies (2015) (22)
Absence of Strand Breaks in Deoxyribonucleic Acid Treated with Metronidazole (1978) (22)
Fibrolamellar hepatocellular carcinoma presenting with budd‐chiari syndrome, right atrial thrombus, and pulmonary emboli (2012) (21)
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A* (2017) (21)
Liver transplantation for primary sclerosing cholangitis: impact of risk factors on outcome. (1996) (21)
Biliary excretion of apolipoprotein B by the isolated perfused rat liver. Relationship to receptor-mediated uptake of human low-density lipoprotein and biliary lipid secretion. (1987) (21)
Early Cholangiocarcinoma Detection With Magnetic Resonance Imaging Versus Ultrasound in Primary Sclerosing Cholangitis (2020) (21)
The zebrafish as a model to study polycystic liver disease. (2013) (21)
Primary sclerosing cholangitis: the gut-liver axis. (2012) (21)
Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis. (2020) (20)
Pharmacologic perturbation of rat liver lysosomes: effects on release of lysosomal enzymes and of lipids into bile. (1988) (20)
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. (2014) (20)
Regulated vesicle trafficking of membrane transporters in hepatic epithelia. (2005) (19)
The Human Immunodeficiency Virus Type 1 Tat Protein Enhances Cryptosporidium parvum-Induced Apoptosis in Cholangiocytes via a Fas Ligand-Dependent Mechanism (2006) (19)
Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis. (2020) (19)
Processing of cholecystokinin by isolated liver cells. (1989) (19)
Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement: A Randomized Clinical Trial. (2020) (18)
Polycystic Liver Disease: The Benefits of Targeting cAMP. (2016) (18)
An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort (2020) (18)
Host cell actin remodeling in response to Cryptosporidium. (2008) (18)
Perceived impact of duty hours limits on the fragmentation of patient care: results from an academic health center. (2005) (18)
MicroRNAs and Benign Biliary Tract Diseases (2015) (18)
Surreptitious laxative ingestion. Delayed recognition of a serious condition: a case report. (1975) (17)
Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. (1998) (17)
Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets (2020) (16)
PC.01.8 THE AESOP TRIAL: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY OF OBETICHOLIC ACID IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS (2018) (16)
Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor (2020) (16)
Case Report: Optimization of a Research Web Environment for Academic Internal Medicine Faculty (2002) (16)
Research productivity of graduates from 3 physician-scientist training programs. (2008) (16)
MicroRNA 15 a modulates expression of the cell-cycle regulator Cdc 25 A and affects hepatic cystogenesis in a rat model of polycystic kidney disease (2008) (15)
The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1 (2019) (15)
Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease. (2018) (15)
Is primary sclerosing cholangitis a progressive disease or not? (1988) (15)
Diurnal serum levels of primary conjugated bile acids 1 (1978) (15)
Cholangiocyte‐specific rat liver proteins identified by establishment of a two‐dimensional gel protein database (1998) (14)
Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion. (2004) (14)
Hepatic processing of recombinant human renin: mechanisms of uptake and degradation. (1991) (14)
Gastroenterology: An international journal (1995) (14)
DISTRIBUTION OF CRYPTOSPORIDIUM PARVUM SPOROZOITE APICAL ORGANELLES DURING ATTACHMENT TO AND INTERNALIZATION BY CULTURED BILIARY EPITHELIAL CELLS (2005) (14)
Insignificant effect of secretin in rodent models of polycystic kidney and liver disease. (2012) (14)
Impact of a cognitive computing clinical trial matching system in an ambulatory oncology practice. (2018) (14)
A study of 6,000 electronic specialty consultations for person-centered care at The Mayo Clinic (2012) (14)
Upregulation of secretin receptors on cholangiocytes after bile duct ligation (2001) (13)
Centers, institutes, and the future of clinical departments: Part II. (2003) (13)
Emerging pharmacologic therapies for primary sclerosing cholangitis (2017) (13)
Focal Dilatation of Intrahepatic Bile Ducts (Caroli's Disease), Cholangiocarcinoma, and Sclerosis of Extrahepatic Bile Ducts: A Case Report (1982) (13)
Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes (1995) (13)
Human intestinal and biliary cryptosporidiosis. (1999) (12)
Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target (2022) (12)
Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2-/- mouse (2021) (12)
Focus on "Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover". (2002) (11)
Experimental models to study cholangiocyte biology. (2002) (11)
Hepatic extraction of renin: Quantitation and characterization in the isolated perfused rat liver (1987) (11)
Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis (2018) (11)
Isolation of primary cilia for morphological analysis. (2009) (11)
Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models (2020) (10)
Chronic Inflammation of Liver and Gut (2009) (10)
P1184 : Age, bilirubin and albumin, regardless of sex, are the strongest independent predictors of biochemical response and transplantation-free survival in patients with primary biliary cirrhosis (2015) (10)
Computed Tomography and Peritoneoscopy for Detection of Liver Metastases: Review of Mayo Clinic Experience (1983) (10)
Physician perspectives on electronic consultations for specialty care delivery for patients: implications for person-centered medicine (2012) (10)
Role of the Intestinal Microbiome in Cholestatic Liver Disease (2017) (10)
Lack of metabolic effects of cholecystokinin on hepatocytes (1990) (10)
Biliary tract physiology (1999) (10)
The Application of Design Principles to Innovate Clinical Care Delivery (2009) (10)
Cholangiocyte Myosin IIB Is Required for Localized Aggregation of Sodium Glucose Cotransporter 1 to Sites of Cryptosporidium parvum Cellular Invasion and Facilitates Parasite Internalization (2010) (10)
34 UPREGULATION OF MIR-506 LEADS TO DECREASED AE2 EXPRESSION IN BILIARY EPITHELIUM OF PATIENTS WITH PRIMARY BILIARY CIRRHOSIS (2012) (9)
Calcium signaling in cilia and ciliary‐mediated intracellular calcium signaling: Are they independent or coordinated molecular events? (2014) (9)
Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks. (2000) (9)
The ins and outs of membrane movement in biliary epithelia. (1991) (9)
Proceedings: Mechanism of action of chenodeoxycholic acid in gallstone dissolution. (1973) (9)
Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis (2021) (9)
Health reform: a community experience using design research as a guide. (2011) (8)
Current therapies and clinical controversies in the management of primary sclerosing cholangitis (2000) (8)
Cholangiocyte biology (2002) (8)
Ursodeoxycholic acid unsaturates bile at a lower dose than chenodeoxycholic acid (1978) (8)
AN IMPROVED METHOD FOR FÆCAL COLLECTION : THE FÆCAL FIELD-KIT (1973) (8)
The role of bile acids in intestinal absorption of cholesterol (1983) (8)
Cholangiocyte biology (2007) (8)
Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease (2017) (8)
Biological characteristics of primary cultures of human gallbladder epithelial cells. (1992) (8)
Plasmaperfusion and studies of copper metabolism in benign recurrent cholestasis: novel procedures in a rare syndrome. (1980) (8)
B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease. (2017) (7)
Polycystic Liver Disease: Advances in Understanding and Treatment. (2021) (7)
Is primary sclerosing cholangitis a bad disease? (1987) (7)
Innovations in the delivery of primary care services using a software solution: the Mayo Clinic’s Generic Disease Management System (2012) (7)
Xanthomatous neuropathy of liver. (1982) (7)
Cholangiocyte bile salt transporters in cholesterol gallstone–susceptible and resistant inbred mouse strains (2008) (7)
High‐Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases (2021) (6)
Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins (2021) (6)
Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation (2021) (6)
107 Cholangiocytes contain primary cilia that function as sensory organelles: potential role in ductal bile formation (2003) (6)
Development and application of methodology for assessing the role of lysosomes in experimental ulcerogenesis in the guinea pig. (1983) (6)
Sclerosing Cholangitis: Pathogenesis, Pathology, and Practice (1999) (5)
Enzymatic determination of total 3 alpha-hydroxy bile acids in faeces. Validation in healthy subjects of a rapid method suitable for clinical routine purpose. (1982) (5)
Immunohistologic labeling of infiltrating T lymphocytes in hepatic allografts: a rejection indicator. (1987) (5)
Behavioral Patterns of Total Serum Bilirubin Prior to Major Clinical Endpoints in 3529 Patients with Primary Biliary Cholangitis (2016) (5)
Genetics, pathobiology and therapeutic opportunities of polycystic liver disease (2022) (5)
Purification and immunological quantification of rat liver lysosomal glycosidases. (1989) (5)
Bilirubin is predictive of transplant-free survival even within the normal range in primary biliary cholangitis patients (2017) (5)
Erratum: Human Oggl, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide (Cancer Research (September 1, 2001) (6388-6393)) (2001) (5)
Long Non-Coding RNA ACTA2-AS1 Promotes Ductular Reaction by Interacting with the p300/ELK1 Complex (2021) (5)
Vesicle-dependent transport pathways in liver cells (1993) (5)
Centers, Institutes, and the future of clinical departments: part I. (2003) (5)
Human Ogg 1 , a Protein Involved in the Repair of 8-Oxoguanine , Is Inhibited by Nitric Oxide 1 (2001) (5)
Purification and partial characterization of a heat-resistant, cytosolic neuropeptidase from rat liver. (1994) (4)
Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles (2020) (4)
The Gut‐Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link? (2019) (4)
Think Big, Start Small, Move Fast: A Blueprint for Transformation from the Mayo Clinic Center for Innovation (2014) (4)
Bile formation: Do not ignore the role of plasma membrane–cytoskeleton linking proteins (2003) (4)
Electropermeabilization: Getting inside the cell to study autophagy (1988) (4)
Cellular senescence in the cholangiopathies (2021) (4)
Autophagy-mediated reduction of miR-345 contributes to hepatic cystogenesis in polycystic liver disease (2021) (4)
Therapeutics , Targets , and Chemical Biology HDAC 6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth (2013) (4)
The "age" factor in adult medicine. (2003) (3)
A learner-centered academic career development curriculum. (2002) (3)
Improving Attendance at Medical Grand Rounds: In Response (2003) (3)
Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. (1997) (3)
Functional polarity of Na 1 / H 1 and Cl 2 / HCO 3 2 exchangers in a rat cholangiocyte cell line (1998) (3)
Bacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Disease (2019) (3)
Familial occurrence of liver disease and inflammatory bowel disease in primary sclerosing cholangitis (1987) (3)
Ursodeoxycholic acid ingestion after ileal resection (1981) (3)
Molecular mechanism of cryptosporidium parvum invasion of biliary epithelia (2001) (2)
Sampling intestinal content with a sequestering capsule. A noninvasive technique for determining bile acid kinetics in man. (1976) (2)
Exosome-like Vesicles are Present in the Lumen of Rat Bile Ducts and Interact with Cholangiocyte Primary Cilia (2007) (2)
The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice. (1999) (2)
Additional evidence for AQP1 vesicle trafficking as a molecular mechanism for ductal bile secretion (2001) (2)
Microbiome‐immune interactions and liver disease (2015) (2)
Correspondence. Circulating Immune Complexes in Primary Sclerosing Cholangitis (1984) (2)
Oral nicotine in the treatment of primary sclerosing cholangitis: A pilot study (1998) (2)
Primary sclerosing cholangitis (1994) (2)
Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis. (2017) (2)
Alkaline phosphatase normalization is associated with a decreased risk for liver transplantation and death in patients with primary biliary cholangitis (2018) (2)
Pancreatobiliary Ductal Dilatation: Unique Pathobiological Processes and Endoscopic Revelations. (2019) (2)
Defining the relationship between autoimmune disease and primary sclerosing cholangitis (2000) (2)
An aluminum silicate binding assay for quantitation of degradation of cholecystokinin octapeptide and other short peptides. (1992) (2)
Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. (2013) (2)
A prospective comparison of fluorescence in situ hybridization (FISH) and Routine cytology (RC) for the identification of malignancy in biliary tract stress (2001) (2)
Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. (1999) (2)
Primary Sclerosing Cholangitis and Celiac Disease (2020) (2)
Lysosomal enzymes in biological fluids (1979) (2)
Cholangiocyte biology (2006) (2)
Animal Model of Autosomal Dominant Polycystic Kidney Disease (2010) (2)
Physiology of Cholngiocytes (2018) (2)
Development and initial application of a microperfusion model of intrahepatic mouse bile duct units (2000) (2)
Cholangiocytes in health and disease: From basic science to novel treatments. (2018) (2)
Gene expression and polarized distribution of membrane acid/base carriers in a differentiated rat cholangiocyte cell line (NRC-1) (1997) (2)
Alterations in Hepatocyte Lysosomes Copper Overload in Rats in Experimental Hepatic (1993) (2)
Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis (2022) (2)
90th Annual Convention Poster Presentations and Abstracts (1991) (1)
M1761 MicroRNA-15a Post-Transcriptionaly Regulates Expression of the Cell Cycle Regulator, Cdc25a, Affecting Cholangiocyte Proliferation and Cyst Growth in the PCK Rat, An Animal Model of Autosomal Recessive Polycystic Kidney Disease (ARPKD) (2008) (1)
Oral pirfenidone in the treatment of primary sclerosing cholangitis (2000) (1)
Patients, cells, and organelles: The intersection of science and serendipity (2011) (1)
Quantitative analysis of the intrahepatic biliary ductal system of polycystic rats by three dimensional reconstruction (2001) (1)
Additional evidence for channel-mediated water transport by biliary epithelia (1998) (1)
Overexpression of Mirna-506 in Human Cholangiocytes Causes Primary Biliary Cholangitis-Like Features including Mitochondrial Dysfunction and Increased Sensitivity to Apoptosis (2016) (1)
Gaining acceptance to Gastroenterology: How the review process works (1993) (1)
Biliary tract physiology. (2000) (1)
Examining the increased IgM production and ursodeoxycholic acid treatment in PBC. (2005) (1)
Wilson's disease. (Major problems in internal medicine, volume 23): By I. H. Scheinberg and I. Sternlieb. 171 pp., $35.00. WB Saunders Company, Philadelphia, Pennsylvania, 1984 (1984) (1)
Alterations in Fas and Fas ligand expression in cholangiocarcinoma: A mechanism of escape from immunosurveillance (1998) (1)
A 59-Year-Old Man With New Jaundice. (2017) (1)
25 Fibrocystin, the ARPKD protein, is localized to cholangiocyte cilia and is disrupted in the orthologous rat model, PCK (2003) (1)
Expression in Cholangiocytes -Induced B7-H1 γ and Is Involved in IFN- MicroRNA-513 Regulates B7-H1 Translation (2013) (1)
Temporal Elements in Career Selection Decisions: An Archival Study Investigating Career Decisions in Medicine (2014) (1)
Chapter 56 – Physiology of Cholangiocytes (2012) (1)
The time course of histological progression in primary sclerosing cholangitis (1998) (1)
The AASLD: Today and tomorrow (1998) (1)
Aquaporin-Mediated Water Transport in Intrahepatic Bile Duct Epithelial Cells (2020) (1)
In Memoriam: Alan F. Hofmann, MD, PhD, May 17, 1931, to September 7, 2021. (2022) (1)
DNA methylation profile of liver tissue in end-stage cholestatic liver disease (2022) (1)
Wilson's disease. (Major problems in internal medicine, volume 23) (1984) (1)
Incidence and Impact of Decompensating Events in Primary Biliary Cirrhosis : Results of an International Follow Up Study of 3030 Patients (2015) (1)
The American Liver Foundation celebrates 10 years of achievement by establishing the Liver Scholar Award (1986) (1)
TGR 5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases via cAMP / G α s signaling Short title : TGR 5 in hepatic cystogenesis (2017) (1)
Cryptosporidium parvum invades human cholangiocytes by activating a CDC42 signaling pathway causing actin remodeling (2003) (1)
Bile acid feeding downregulates expressions of asbt and t-ASBT in cholangiocytes (2000) (1)
Selective aquaporin gene silencing using small interfering RNAs in isolated rat intrahepatic bile duct units Technical development and functional assessment (2002) (1)
Patients with primary sclerosing cholangitis and gallbladder polyps should undergo cholecystectomy (2001) (1)
Chapter Twenty-Six – Primary sclerosing cholangitis (2006) (1)
Application of Correlative Fluorescence and Electron Microscopy for Morphological Characterization of Individual Transfected Pancreas and Biliary Epithelial cells (2005) (1)
An improved method for faecal collection: the faecal field-kit. (1973) (1)
Passing the torch: a look back at our editorship. (1996) (1)
476 Isolation and characterization of specialized microdomains of hepatocyte plasma membranes: Potential role in canalicular bile formation (2003) (1)
Cholangiocyte biology (2004) (1)
460 The biophysical properties of hepatocyte plasma membrane domains influence water transport: The canalicular membrane is rate-limiting (2003) (1)
P1180 : Identification of pbc patients in need of additional therapy during the course of UDCA treatment -an international multicenter study (2015) (1)
Comparative Performance of Quantitative and Qualitative Magnetic Resonance Imaging Metrics in Primary Sclerosing Cholangitis (2022) (1)
M1746 Toll-Like Receptor 4-Mediated Immune Response Is Required for In Vivo Eradication of C. Parvum Infection of the Biliary Tract (2008) (1)
Mo1005 Performance of Magnetic Resonance Elastography in Primary Sclerosing Cholangitis (2015) (1)
Nitric oxide (NO) inhibits apoptosis in cholangiocarcinoma cells by blocking caspase 9 activation (2000) (1)
721. Measles Virus for Cancer Gene Therapy of Primary Liver Tumors (2005) (1)
Cholangiocyte Cilia and Basal Bodies (2010) (1)
Health Care Innovation in Practice (2014) (0)
Hail to the chief—Keith Lindor, our new AASLD president (2016) (0)
Miles Fiterman, Obituary (2004) (0)
In Memoriam: Martin Brotman, (1939-2020). (2021) (0)
M1171 Myosin II-Dependent Membrane Translocation of SGLT1 and Aqp1 Is Required for Efficient C. Parvum Cellular Invasion of Cholangiocytes (2008) (0)
Combined targeting of cholangiocytes and activated stromal cells with a BH3 mimetic ameliorates fibrosis in a mouse model of PSC (2017) (0)
Pathophysiology of Cholangiocyte Cilia (2006) (0)
Increase in age at diagnosis of primary biliary cholangitis over the last 40 years (2017) (0)
Portal fibroblasts: A renewable source of liver myofibroblasts (2022) (0)
431 A Novel MicroRNA Panel Accurately Diagnoses Cholangiocarcinoma Using Nearest Shrunken Centroids (2008) (0)
BILE ACID PROFILES PREDICT HEPATIC DECOMPENSATION IN PRIMARY SCLEROSING (2019) (0)
Too much bench, not enough bedside? (1995) (0)
Charles Richard Fleming (1999) (0)
Farther, faster, and (hopefully) better! (1992) (0)
P1177 : Risk factors for hepatic decompensation in primary biliary cirrhosis - results of an international follow up study of 2326 patients (2015) (0)
Abstract LB-505: Molecular mechanisms of deciliation and malignant transformation in cholangiocarcinoma (2012) (0)
1103 - Fluorescence-Activated Cell Sorting of Enteroendocrine Cells in Humans: Technique Validation by Mucosal Endoscopic Biopsies and Novel Progression to Ex-Vivo Studies (2018) (0)
Reply to Otero and Szabo (2007) (0)
For consideration of publication in Infection and Immunity HIV-1 Tat Protein Enhances Cryptosporidium parvum -induced Apoptosis in Cholangiocytes via a Fas Ligand-dependent Mechanism Running title: Synergistic effect of Tat on C. parvum-induced apoptosis (2006) (0)
355 POLYCYSTIC HUMAN CHOLANGIOCYTES SHOW INCREASED MATRIX-METALLOPROTEASE ACTIVITY STIMULATED BY INTERLEUKIN-6, INTERLEUKIN-8 AND ESTROGENS (2012) (0)
P1147 : Validation of an alkaline phosphatase and bilirubin response criterion as biomarker for transplant-free survival in primary biliary cirrhosis in the world's two largest cohorts (2015) (0)
Stratification of hepatocellular carcinoma risk using the GLOBE score in patients with primary biliary cholangitis– the Global PBC Study Group (2018) (0)
M1741a SRC Kinase-Dependent MLCK Activation Mediates Tight Junction (TJ) Disruption By Hydrogen Peroxide and TNFα in Bile Duct Epithelium (2008) (0)
Sclerosing cholangitis. (1997) (0)
Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis (2023) (0)
Association between ursodeoxycholic acid therapy and prolonged transplant-free survival among patients with primary biliary cholangitis a number needed to treat analysis (2016) (0)
The ins and outs of bile acid transport (2002) (0)
Development of antibodies to the ARPKD protein, fibrocystin, and demonstration of ciliary expression in MDCK cells (2003) (0)
An Octogenarian With Acute Epigastric Pain: More Than Meets the Eye. (2016) (0)
Bidirectional water transport across biliary epithelia (2000) (0)
446 – Modulation of Bile Acids Pathway in Obesity and Type 2 Diabetes (2019) (0)
A Salute to the AGA Legacy Society (2016) (0)
Polycystic Liver Diseases (2020) (0)
Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics. (2009) (0)
8-Oxoguanine , Is Inhibited by Nitric Oxide Human Ogg 1 , a Protein Involved in the Repair of Updated (2001) (0)
Healthcare innovation in practice (2014) (0)
Defining the relationship between antoimmune disease and primary sclerosing cholangitis (2000) (0)
The epigenetic reader, BRD2, mediates cholangiocyte senescence via interaction with ETS1. (2023) (0)
Cholangiocyte biology. (2005) (0)
incidence and Impact of Decompensating Events in Primary Biliary Cirrhosis - Results of an International Follow Up Study of 3030 Patients. : 73 (2015) (0)
For consideration of publication in Hepatology Cholangiocyte Autophagy Contributes to Hepatic Cystogenesis in Polycystic Liver Disease and Represents a Potential Therapeutic Target Short title : Autophagy in PLD (2017) (0)
T1817 Implication of PLCγ and PKC in the Mechanism of Epidermal Growth Factor (EGF) Protection Against Hydrogen Peroxide and TNFα-Induced Disruption of Tight Junctions (TJS) in Bile Duct Epithelium (2008) (0)
Proteostasis improvement in cystic cholangiocytes alleviates endoplasmic reticulum stress and halts polycystic liver disease (2020) (0)
Younger age is associated with lower transplant-free survival relative to a general population in patients with Primary Biliary Cholangitis (2018) (0)
Improving attendance at medical grand rounds. Authors' reply (2003) (0)
Hepatic Drug Metabolism and Malignancy (1976) (0)
Glutathione depletion in human cholangiocytes is associated with increased BCL-2 degradation and enhanced apoptosis (1998) (0)
Hepatocyte Lysosomes in Intracellular Digestion and Biliary Secretion (2011) (0)
Autophagy is Involved in HDAC6 Mediated Ciliary Loss, and Increases Malignancy in Cholangiocarcinoma Models (2017) (0)
Chapter 20 – Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis (2010) (0)
M1773 P2Y12 and the Components of the AKAP-Signaling Complex Are Localized to Cholangiocyte Cilia Providing Chemosensory Functions of These Organelles (2008) (0)
Editorial: Hepatic drug metabolism and malignancy. (1976) (0)
Cryptosporidium parvum infection of biliary epithelia occurs via specific glycoproteins on the apical cholangiocyte plasma membrane (1998) (0)
Primary Sclerosing Cholangitis. (2022) (0)
The AGA Institute: a professional society with a social conscience. (2008) (0)
Chapter 41 – Primary sclerosing cholangitis (2012) (0)
Cryptosporidium and Bile Duct Injury (2020) (0)
P1182 : MIR-506 is upregulated by pro-inflammatory cytokines in human cholangiocytes and inhibits cell proliferation and adhesion (2015) (0)
M1169 NF-κB Mediated-Transcriptional Regulation of a Cellular MicroRNA, LET-7i, Contributes to Biliary Epithelial Immunity Against Cryptosporidium Parvum Infection (2008) (0)
Three-Dimensional Reconstruction of the Rat Intrahepatic Biliary Tree: (2020) (0)
Gastroenterology's editors-in-chief (2013) (0)
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Oxide-dependent Mechanism repair in Cholangiocarcinoma Cells by a Nitric Inflammatory Cytokines Induce DNA damage and Inhibit DNA (2000) (0)
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