Nicholas Francis Larusso
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Biology
Nicholas Francis Larusso's Degrees
- PhD Biomedical Sciences University of California, San Francisco
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)Nicholas Francis Larusso's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs (2015) (1299)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. (2000) (656)
- Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis (1989) (588)
- Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. (1996) (514)
- Biliary tract cancers. (1999) (486)
- A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection* (2007) (442)
- Clinicopathologic features of the syndrome of primary sclerosing cholangitis (1980) (389)
- The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis (2000) (371)
- A revised natural history model for primary sclerosing cholangitis. (1997) (349)
- The cholangiopathies: disorders of biliary epithelia. (2004) (341)
- Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. (1991) (334)
- Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. (2003) (308)
- Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease. (2010) (306)
- Primary sclerosing cholangitis: findings on cholangiography and pancreatography. (1983) (301)
- The Value of Serum CA 19-9 in Predicting Cholangiocarcinomas in Patients with Primary Sclerosing Cholangitis (2005) (301)
- Long‐term results of patients undergoing liver transplantation for primary sclerosing cholangitis (1999) (297)
- Recurrence of primary sclerosing cholangitis following liver transplantation (1999) (296)
- Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis (1981) (290)
- Characterization of PKD protein-positive exosome-like vesicles. (2009) (287)
- Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. (2001) (287)
- The pathobiology of biliary epithelia (2002) (285)
- Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (2007) (281)
- MicroRNA‐21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3 (2009) (273)
- Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. (2006) (267)
- The isolated perfused rat liver: Conceptual and practical considerations (1986) (264)
- Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations. (1985) (249)
- Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. (2010) (248)
- Primary sclerosing cholangitis: refinement and validation of survival models. (1992) (248)
- Primary sclerosing cholangitis: Summary of a workshop (2006) (247)
- Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. (1997) (233)
- Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. (1996) (224)
- Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. (2013) (213)
- High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis (2000) (211)
- The Pathophysiology of Biliary Epithelia (2004) (211)
- Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. (2001) (209)
- Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. (1989) (209)
- Cholangiocyte pathobiology (2019) (207)
- An aged immune system drives senescence and ageing of solid organs (2021) (207)
- Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. (2001) (205)
- Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB1 (2005) (201)
- Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. (1974) (198)
- Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. (2003) (192)
- Up‐regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis (2012) (192)
- MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes12 (2009) (191)
- Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion (2007) (190)
- The Water Channel Aquaporin-8 Is Mainly Intracellular in Rat Hepatocytes, and Its Plasma Membrane Insertion Is Stimulated by Cyclic AMP* (2001) (189)
- Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. (2001) (188)
- Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis. (1993) (184)
- Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. (1984) (184)
- Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. (1985) (183)
- Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane (1997) (182)
- Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. (1985) (180)
- Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion. (1987) (177)
- Primary sclerosing cholangitis. (1984) (177)
- Cholangiocyte senescence by way of N‐ras activation is a characteristic of primary sclerosing cholangitis (2014) (177)
- Recent advances in the isolation of liver cells (1994) (174)
- Gallbladder disease in patients with primary sclerosing cholangitis. (1988) (173)
- HDAC6 inhibition restores ciliary expression and decreases tumor growth. (2013) (172)
- Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis (2016) (170)
- MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. (2008) (164)
- Physiology of cholangiocytes. (2013) (164)
- Extracellular vesicles in liver pathobiology: Small particles with big impact (2016) (156)
- Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis. (2000) (155)
- Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients. (1975) (154)
- Prospective trial of penicillamine in primary sclerosing cholangitis. (1988) (154)
- Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense (2013) (153)
- Clinicopathologic features of the syndrome of primary sclerosing cholangitis. (1980) (152)
- Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. (1988) (151)
- Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism. (1992) (150)
- Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. (2008) (147)
- Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis (1992) (142)
- Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. (1996) (140)
- Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. (2001) (140)
- Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. (1997) (140)
- Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. (1994) (140)
- Effect of proctocolectomy for chronic ulcerative colitis on the natural history of primary sclerosing cholangitis. (1989) (136)
- Cholangiocyte primary cilia in liver health and disease (2008) (136)
- Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis. (1986) (132)
- Cholelitholysis using methyl tertiary butyl ether. (1985) (130)
- Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. (2007) (130)
- Efficacy and Safety of Transarterial Radioembolization Versus Chemoembolization in Patients With Hepatocellular Carcinoma (2013) (130)
- Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. (1998) (128)
- Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. (2000) (128)
- Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. (2007) (127)
- The Cholangiopathies. (2015) (127)
- Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. (1999) (127)
- Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease. (1990) (125)
- Elevated Circulating Immune Complexes in Primary Sclerosing Cholangitis (2007) (125)
- The relative role of the child‐pugh classification and the mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis (1999) (125)
- Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. (2003) (124)
- Bcl‐2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line (1997) (124)
- The dynamic biliary epithelia: molecules, pathways, and disease. (2013) (123)
- Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. (1977) (123)
- The combination of prednisone and colchicine in patients with primary sclerosing cholangitis. (1991) (121)
- Water transport by epithelia of the digestive tract. (2002) (120)
- The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD) (2009) (119)
- Somatostatin analog therapy for severe polycystic liver disease: results after 2 years. (2012) (119)
- Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload. (1989) (118)
- Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes* (2003) (118)
- The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population. (2007) (114)
- Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. (1994) (113)
- Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. (2013) (112)
- Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases (2013) (111)
- Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma (2006) (111)
- Manifestations of nonsuppurative cholangitis in chronic hepatobiliary diseases: morphologic spectrum, clinical correlations and terminology. (2008) (110)
- Primary Sclerosing Cholangitis (1984) (110)
- Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. (1998) (110)
- Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects. (1975) (110)
- Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells. (2000) (109)
- Expression and Localization of Aquaporin Water Channels in Rat Hepatocytes (2002) (107)
- Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. (1983) (106)
- Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. (2004) (106)
- Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application (1980) (105)
- A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. (2007) (104)
- NFκB p50-CCAAT/Enhancer-binding Protein β (C/EBPβ)-mediated Transcriptional Repression of MicroRNA let-7i following Microbial Infection* (2009) (104)
- Apolipoproteins of high, low, and very low density lipoproteins in human bile. (1983) (104)
- Primary sclerosing cholangitis and celiac disease. A novel association. (1988) (102)
- The metabolic bone disease of primary sclerosing cholangitis (1991) (102)
- Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. (1991) (97)
- Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer? (1997) (97)
- Isolation and characterization of cholangiocyte primary cilia. (2006) (96)
- In primary sclerosing cholangitis, gallbladder polyps are frequently malignant (2002) (96)
- MicroRNAs: key modulators of posttranscriptional gene expression. (2009) (95)
- Interaction of metronidazole with nucleic acids in vitro. (1977) (94)
- Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. (1995) (94)
- Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism (1998) (93)
- Proteolytic Cleavage and Nuclear Translocation of Fibrocystin Is Regulated by Intracellular Ca2+ and Activation of Protein Kinase C* (2006) (92)
- Nonoperative dilatation of dominant strictures in primary sclerosing cholangitis. (1985) (92)
- Cholangiocarcinoma complicating primary sclerosing cholangitis: cholangiographic appearances. (1985) (91)
- Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. (2006) (90)
- Proteins in bile: how they get there and what they do. (1984) (89)
- Coordinate secretion of acid hydrolases in rat bile. (1979) (89)
- Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. (2010) (89)
- Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study. (1996) (88)
- Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. (2001) (88)
- Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload. (1986) (86)
- Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion. (2005) (86)
- Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. (1999) (85)
- Primary sclerosing cholangitis with normal serum alkaline phosphatase activity. (1988) (85)
- Cholangiociliopathies: genetics, molecular mechanisms and potential therapies (2009) (84)
- T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. (2006) (84)
- Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. (2018) (84)
- Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. (1975) (83)
- Performance of magnetic resonance elastography in primary sclerosing cholangitis (2016) (78)
- Polycystic liver diseases: advanced insights into the molecular mechanisms (2014) (78)
- Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes (2006) (78)
- Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion (2004) (77)
- Abnormalities in tests of copper metabolism in primary sclerosing cholangitis. (1985) (77)
- Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. (2003) (77)
- Glucagon induces the plasma membrane insertion of functional aquaporin‐8 water channels in isolated rat hepatocytes (2003) (77)
- Intrahepatic cholangiectases and large‐duct obliteration in primary sclerosing cholangitis (1986) (77)
- Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. (2008) (76)
- Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging (2018) (75)
- Stimulation of ATP secretion in the liver by therapeutic bile acids. (2001) (74)
- Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5‐trisphosphate receptor isoforms (2002) (74)
- Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. (1997) (73)
- Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning (2020) (73)
- Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. (1995) (73)
- Primary sclerosing cholangitis: value of cholangiography in determining the prognosis. (1991) (73)
- Anatomy of the human biliary system studied by quantitative computer‐aided three‐dimensional imaging techniques (1998) (73)
- A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis (2020) (72)
- Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts. (1993) (72)
- Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis (2014) (72)
- The immunobiology of cholangiocytes (2008) (72)
- Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. (2003) (71)
- CRYPTOSPORIDIUM PARVUM ATTACHMENT TO AND INTERNALIZATION BY HUMAN BILIARY EPITHELIA IN VITRO: A MORPHOLOGIC STUDY (2004) (71)
- Interactions between chronic liver disease and inflammatory bowel disease. (1997) (70)
- In primary sclerosing cholangitis, gallbladder polyps are frequently malignant. (2002) (70)
- Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid. (1978) (69)
- Phosphatidylinositol 3-Kinase and Frabin Mediate Cryptosporidium parvum Cellular Invasion via Activation of Cdc42* (2004) (69)
- Abnormalities of chemical tests for copper metabolism in chronic active liver disease: differentiation from Wilson's disease. (1976) (67)
- Cholangiocyte N-Ras Protein Mediates Lipopolysaccharide-induced Interleukin 6 Secretion and Proliferation* (2011) (67)
- Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. (1993) (67)
- Rat hepatocyte aquaporin‐8 water channels are down‐regulated in extrahepatic cholestasis (2003) (66)
- Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. (2010) (65)
- Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice (2018) (65)
- Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains. (1995) (65)
- Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: ileal pouch-anal anastomosis versus Brooke ileostomy. (1996) (64)
- Biliary proteins: assessment of quantitative techniques and comparison in gallstone and nongallstone subjects. (1988) (64)
- Cholangiocarcinomas express fas ligand and disable the fas receptor (1999) (63)
- Water Transporting Properties of Hepatocyte Basolateral and Canalicular Plasma Membrane Domains* (2003) (63)
- Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. (1997) (63)
- Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy. (2002) (63)
- Current concepts. Primary sclerosing cholangitis. (1994) (61)
- Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin. (1993) (60)
- ATP binding cassette transporter gene expression in rat liver progenitor cells (2003) (59)
- Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography. (1984) (59)
- Cholangiocarcinoma complicating primary sclerosing cholangitis. (1991) (59)
- Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400412-JLR200 (2005) (58)
- Specific Inhibition of AQP1 Water Channels in Isolated Rat Intrahepatic Bile Duct Units by Small Interfering RNAs* (2003) (58)
- MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation (2018) (58)
- Aquaporins in the hepatobiliary system (2006) (58)
- Complications and risk factors after ileal pouch-anal anastomosis for ulcerative colitis associated with primary sclerosing cholangitis. (1993) (58)
- Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. (2001) (58)
- Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines (1998) (58)
- Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs. (2011) (57)
- Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. (2015) (57)
- Enhanced autoreactivity of T‐lymphocytes in primary sclerosing cholangitis (1987) (57)
- Cdc42 and the Actin-Related Protein/Neural Wiskott-Aldrich Syndrome Protein Network Mediate Cellular Invasion by Cryptosporidium parvum (2004) (56)
- Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition. (1995) (55)
- Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanism of hepatic extraction. (1986) (55)
- Molecular studies of ceruloplasmin deficiency in Wilson's disease. (1987) (55)
- Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis. (1989) (54)
- Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis (2010) (54)
- Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers. (1982) (54)
- Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. (1997) (53)
- Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases (2014) (53)
- Milder disease stage in patients with primary biliary cholangitis over a 44‐year period: A changing natural history (2018) (52)
- The syndrome of primary sclerosing cholangitis. (1990) (52)
- Rat Hepatocytes Transport Water Mainly via a Non-channel-mediated Pathway (*) (1996) (51)
- Aquaporin‐1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis (2010) (51)
- Expression of aquaporin‐4 water channels in rat cholangiocytes (2000) (50)
- Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation. (2003) (50)
- MicroRNA (miR)‐433 and miR‐22 dysregulations induce histone‐deacetylase‐6 overexpression and ciliary loss in cholangiocarcinoma (2018) (49)
- Diagnosis and treatment of primary sclerosing cholangitis. (1985) (49)
- Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma. (2004) (49)
- Oral Nicotine in Treatment of Primary Sclerosing Cholangitis (A Pilot Study) (2004) (49)
- Development of an intravenous bile acid tolerance test. Plasma disappearance of cholylglycine in health. (1975) (48)
- Determinants of fasting and postprandial serum bile acid levels in healthy man (1978) (47)
- A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis (2000) (46)
- Intrahepatic bile ducts transport water in response to absorbed glucose. (2002) (45)
- Cryptosporidium parvum infects human cholangiocytes via sphingolipid‐enriched membrane microdomains (2006) (44)
- Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. (2005) (43)
- Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions. (2000) (42)
- Development and characterization of a rodent model of immune-mediated cholangitis. (1996) (42)
- Expression and Localization of Aquaporin Water Channels in Rat Hepatocytes EVIDENCE FOR A ROLE IN CANALICULAR BILE SECRETION* (2002) (42)
- Advances in primary sclerosing cholangitis. (1990) (42)
- Hemobilia: Etiology, diagnosis, and treatment☆. (2018) (42)
- Circadian rhythms of biliary protein and lipid excretion in rats. (1990) (41)
- Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. (1998) (41)
- HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis. (2014) (40)
- Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease (2006) (40)
- TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling (2017) (39)
- Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. (2012) (39)
- Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. (1990) (39)
- Primary sclerosing cholangitis: a progressive disease? (1991) (39)
- Primary sclerosing cholangitis. (1984) (38)
- Rab3D, a small GTP–binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes (2000) (38)
- Aquaporin water channels in liver: Their significance in bile formation (1997) (38)
- Therapeutic Targets in Polycystic Liver Disease. (2017) (38)
- If you feed them, they will come: A prospective study of the effects of complimentary food on attendance and physician attitudes at medical grand rounds at an academic medical center (2007) (38)
- Strategies for improving attendance at medical grand rounds at an academic medical center. (2003) (37)
- Solute and water transport pathways in cholangiocytes. (1996) (37)
- Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry (1995) (37)
- Time course of histological progression in primary sclerosing cholangitis (1999) (37)
- Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr 2-/-mice (2017) (37)
- Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer. (2013) (37)
- Functional polarity of Na+/H+and Cl-/[Formula: see text]exchangers in a rat cholangiocyte cell line. (1998) (37)
- Efficacy of 4 Years of Octreotide Long-Acting Release Therapy in Patients With Severe Polycystic Liver Disease. (2015) (37)
- The Role of Cilia in the Regulation of Bile Flow (2011) (36)
- HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum. (2009) (36)
- Effect of chloroquine on the form and function of hepatocyte lysosomes. Morphologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. (1983) (36)
- A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. (2000) (35)
- Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II. (1998) (35)
- Time course of histological progression in primary sclerosing cholangitis. (1999) (35)
- Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. (1977) (35)
- Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? (2017) (34)
- Pathobiology of biliary epithelia and cholangiocarcinoma: Proceedings of the Henry M. and Lillian Stratton basic research single‐topic conference (2008) (34)
- Hepatobiliary disease in inflammatory bowel disease. (1995) (34)
- Functional polarity of Na+/H+ and Cl-/HCO3- exchangers in a rat cholangiocyte cell line. (1998) (33)
- Polycystic liver disease: New insights into disease pathogenesis (2006) (33)
- Cytoskeletal and motor proteins facilitate trafficking of AQP1‐containing vesicles in cholangiocytes (2006) (33)
- Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes (2020) (33)
- Cholangiocyte biology (2003) (32)
- Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease. (2010) (32)
- Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. (1990) (31)
- Physicochemical determinants in hepatic extraction of small peptides (1990) (31)
- Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma. (2017) (31)
- Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B (2005) (31)
- TLR4 Promotes Cryptosporidium parvum Clearance in a Mouse Model of Biliary Cryptosporidiosis (2011) (31)
- The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis (2019) (31)
- Water movement across rat bile duct units is transcellular and channel‐mediated (2001) (31)
- Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units. (2002) (30)
- Epidermal Growth Factor Protects the Apical Junctional Complexes from Hydrogen peroxide in Bile Duct Epithelium (2010) (30)
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- Younger age is associated with lower transplant-free survival relative to a general population in patients with Primary Biliary Cholangitis (2018) (0)
- Improving attendance at medical grand rounds. Authors' reply (2003) (0)
- Hepatic Drug Metabolism and Malignancy (1976) (0)
- Glutathione depletion in human cholangiocytes is associated with increased BCL-2 degradation and enhanced apoptosis (1998) (0)
- Hepatocyte Lysosomes in Intracellular Digestion and Biliary Secretion (2011) (0)
- Autophagy is Involved in HDAC6 Mediated Ciliary Loss, and Increases Malignancy in Cholangiocarcinoma Models (2017) (0)
- Chapter 20 – Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis (2010) (0)
- M1773 P2Y12 and the Components of the AKAP-Signaling Complex Are Localized to Cholangiocyte Cilia Providing Chemosensory Functions of These Organelles (2008) (0)
- Editorial: Hepatic drug metabolism and malignancy. (1976) (0)
- Cryptosporidium parvum infection of biliary epithelia occurs via specific glycoproteins on the apical cholangiocyte plasma membrane (1998) (0)
- Primary Sclerosing Cholangitis. (2022) (0)
- The AGA Institute: a professional society with a social conscience. (2008) (0)
- Chapter 41 – Primary sclerosing cholangitis (2012) (0)
- Cryptosporidium and Bile Duct Injury (2020) (0)
- P1182 : MIR-506 is upregulated by pro-inflammatory cytokines in human cholangiocytes and inhibits cell proliferation and adhesion (2015) (0)
- M1169 NF-κB Mediated-Transcriptional Regulation of a Cellular MicroRNA, LET-7i, Contributes to Biliary Epithelial Immunity Against Cryptosporidium Parvum Infection (2008) (0)
- Three-Dimensional Reconstruction of the Rat Intrahepatic Biliary Tree: (2020) (0)
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- ABC-transporter gene expression in cholangiocytes and hepatic oval cells reveals a multidrug resistance phenotype. (1999) (0)
- Insignificant effect of secretin in rodent models of polycystic kidney and liver disease (2012) (0)
- Histologic stage is a stronger predictor of transplant free survival than APRI and FIB-4 in patients with primary biliary cholangitis (2018) (0)
- M1732 Lipopolysaccharide (LPS) Sensitizes Bile Duct Epithelial Cells for Tight Junction (TJ) Disruption By Hydrogen Peroxide and TNFα By Nitric Oxide-Dependent Mechanism (2008) (0)
- Molecular mechanisms of Cryptospiridium-induced actin cytoskeleton dynamics (2008) (0)
- Bile Acids and the Gut Liver Axis (2017) (0)
- Cholangiocyte Functions in Health and Disease: The Ciliary Connection (2009) (0)
- Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid (2023) (0)
- Gastrointestinal , Hepatobiliary and Pancreatic Pathology Hepato-Renal Pathology in Pkd 2 ws 25 / Mice , an Animal Model of Autosomal Dominant Polycystic Kidney Disease (2010) (0)
- Oxide-dependent Mechanism repair in Cholangiocarcinoma Cells by a Nitric Inflammatory Cytokines Induce DNA damage and Inhibit DNA (2000) (0)
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- Correction to: Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target (2022) (0)
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