Nigel J. M. Birdsall
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Nigel J. M. Birdsallmedical Degrees
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#3139
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Pharmacology
#299
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#348
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Nigel J. M. Birdsall's Degrees
- PhD Pharmacology University of Nottingham
Why Is Nigel J. M. Birdsall Influential?
(Suggest an Edit or Addition)Nigel J. M. Birdsall's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. (1998) (1460)
- Muscarinic receptor subtypes. (1990) (1328)
- Pirenzepine distinguishes between different subclasses of muscarinic receptors (1980) (1266)
- The binding of agonists to brain muscarinic receptors. (1978) (622)
- Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein (1975) (347)
- Modification of the binding properties of muscarinic receptors by gallamine. (1983) (322)
- Reconstitution of a calcium pump using defined membrane components. (1974) (320)
- Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin. (1976) (281)
- Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors. (1995) (263)
- Reversible lipid titrations of the activity of pure adenosine triphosphatase-lipid complexes. (1974) (250)
- Muscarinic receptor subclasses (1983) (242)
- Clusters in lipid bilayers and the interpretation of thermal effects in biological membranes. (1974) (235)
- 13 C nuclear magnetic resonance relaxation measurements of synthetic lecithins and the effect of spin-labeled lipids. (1972) (224)
- Guanine nucleotides modulate muscarinic receptor binding in the heart. (1979) (218)
- Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia (2008) (208)
- Muscarinic cholinergic receptors: Autoradiographic localization of high and low affinity agonist binding sites (1980) (175)
- The character of the muscarinic receptors in different regions of the rat brain (1980) (171)
- Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng‐Prusoíf equations (1993) (171)
- Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging. (1997) (151)
- High resolution proton relaxation studies of lecithins. (1972) (145)
- Ontogeny of muscarinic receptors in rat brain (1980) (138)
- Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis. (1995) (138)
- Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor. (1989) (133)
- Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4. (1993) (124)
- Measurement of fast lateral diffusion of lipids in vesicles and in biological membranes by 1 H nuclear magnetic resonance. (1973) (124)
- 13C NMR Spectra of Lecithin Vesicles and Erythrocyte Membranes (1971) (124)
- Calculation of dipolar nuclear magnetic relaxation times in molecules with multiple internal rotations. II. Theoretical results for anisotropic over‐all motion of the molecule, and comparison with 13C relaxation times in n ‐alkanes and n ‐alkyl bromides (1974) (119)
- Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. (1998) (113)
- Dipalmitoyl-lecithin: assignment of the 1H and 13C nuclear magnetic resonance spectra, and conformational studies (1972) (110)
- Allosterism at muscarinic receptors: ligands and mechanisms. (2005) (108)
- Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. (2000) (106)
- Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. (2004) (102)
- The binding of antagonists to brain muscarinic receptors. (1978) (100)
- Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation. (1993) (92)
- Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies. (1999) (92)
- Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material. (1979) (82)
- Two populations of binding sites for muscarinic antagonists in the rat heart. (1981) (79)
- The interaction of paramagnetic ions and spin labels with lecithin bilayers. (1973) (78)
- 13C Nuclear magnetic relaxation times and models for chain motion in lecithin vesicles (1972) (78)
- Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. (2002) (77)
- 13 C and 1 H nuclear magnetic resonance relaxation measurements of the lipids of sarcoplasmic reticulum membranes. (1972) (76)
- Class A GPCR heterodimers: evidence from binding studies. (2010) (75)
- CORTICAL MUSCARINIC RECEPTOR SUBTYPES AND ALZHEIMER'S DISEASE (1982) (73)
- Regulation of muscarinic agonist binding by cations and guanine nucleotides. (1983) (71)
- Binding of agonists and antagonists to muscarinic receptors. (1976) (63)
- Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes. (1997) (61)
- A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart (1982) (60)
- Modulation of the structure‐binding relationships of antagonists for muscarinic acetylcholine receptor subtypes (1991) (60)
- The role of the cholinergic system in the development of the human cerebellum. (1995) (60)
- The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes. (1989) (57)
- 13C NMR spectra of acholeplasma membranes containing13C labelled phospholipids (1972) (57)
- Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography (1981) (48)
- Simplified 13C spectral assignments using a graphical method to present 13C spectra recorded under conditions of proton off-resonance spin decoupling (1972) (45)
- Receptor-effector coupling : a practical approach (1990) (44)
- A determination of the mobility gradient in lipid bilayers by 13C nuclear magnetic resonance (1976) (43)
- Receptor biochemistry : a practical approach (1990) (43)
- Ligand-binding propeties of the muscarinic acetylcholine receptor in mouse neuroblastoma cells. (1978) (42)
- Pirenzepine--a ligand with original binding properties to muscarinic receptors. (1980) (42)
- Multiple allosteric sites on muscarinic receptors. (2001) (42)
- Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor. (1998) (41)
- Regional distribution of muscarinic and nicotinic cholinergic receptor binding activities in the human brain. (1989) (40)
- Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor. (2000) (39)
- Nuclear Magnetic Relaxation and the Biological Membrane (1974) (39)
- Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells. (1977) (38)
- Modulation of the binding properties of muscarinic receptors: evidence for receptor-effector coupling. (1980) (35)
- Receptor structure: the accelerating impact of molecular biology. (1989) (35)
- Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors. (1999) (34)
- A nuclear magnetic resonance investigation of the conformation of nicotinamide mononucleotide in aqueous solution. (1975) (34)
- The affinity, selectivity and biological activity of telenzepine enantiomers. (1989) (34)
- 19 F NMR of monofluorostearic acids in lecithin vesicles. (1971) (33)
- Allosteric regulation of G-protein-linked receptors. (1995) (31)
- Cloning and structure-function of the H2 histamine receptor. (1991) (30)
- Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus (1993) (29)
- Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides. (2000) (29)
- Presynaptic muscarinic receptors on dopaminergic terminals in the nucleus accumbens (1982) (29)
- Interactions of muscarinic receptors with guanine nucleotides and adenylate cyclase (1981) (28)
- Inhibition of high affinity choline uptake. Structure activity studies. (1980) (27)
- The binding of [3H]telenzepine to muscarinic acetylcholine receptors in calf forebrain. (1988) (26)
- Correlations between oncogenic and chemical properties of several derivatives of 3-hydroxyxanthine and 3-hydroxyguanine. (1973) (25)
- Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand. (1980) (25)
- Muscarinic receptor subtypes and the selectivity of agonists and antagonists. (1988) (23)
- Purine N-oxides—XLI : The 3-acyloxypurine 8-substitution reaction: On the mechanism of the reaction (1972) (23)
- Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate. (1989) (20)
- Soluble and membrane-bound muscarinic acetylcholine receptors. (1986) (20)
- Muscarinic receptor subclasses: evidence from binding studies. (1983) (20)
- Purine n-oxides XXIV. The preparation of 8-substituted xanthines and guanines by a nucleophilic displacement of a 3-substituent (1969) (20)
- The affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor. (1996) (19)
- Solubilisation and molecular characterisation of muscarinic acetylcholine receptors. (1983) (19)
- Allosteric regulation of muscarinic receptors. (1996) (18)
- Quantitation of allosteric interactions. (1996) (18)
- The modes of binding of ligands to cardiac muscarinic receptors. (1989) (16)
- Substituted pentacyclic carbazolones as novel muscarinic allosteric agents: synthesis and structure-affinity and cooperativity relationships. (2002) (15)
- Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors. (1999) (15)
- Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site. (1988) (15)
- Does the prolonged occupancy of M1 receptors by telenzepine protect them against the action of vagally released acetylcholine? (1988) (14)
- Purification of the muscarinic acetylcholine receptor from rat forebrain. (1985) (14)
- Purine N-oxides. XXXV. Alkylated guanine 3-oxides and 3-hydroxyxanthines. (1971) (14)
- 13C-enriched phosphatidylethanolamines from Escherichia coli. (1975) (13)
- 3-(TETRAHYDROPYRIDINYL)INDOLES (1996) (13)
- Use of clonal cell lines in the analysis of neurotransmitter receptor mechanisms and function. (1990) (13)
- The Binding Properties of Muscarinic Receptors (1989) (12)
- Effect of tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo. (1981) (12)
- Purine N-oxides—LII (1971) (12)
- Muscarinic receptor subclasses: allosteric interactions. (1983) (11)
- Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors (2007) (11)
- The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain. (1987) (11)
- Effects of contamination on radioligand binding parameters. (2000) (10)
- Muscarinic interactions of bisindolylmaleimide analogues. (1998) (10)
- A simple synthesis of monofluorostearic acids (1971) (9)
- Purine N-oxides—XXXIX N-acetoxy derivatives of N-hydroxyxanthines (1971) (9)
- Intramolecular Diels−Alder Reactions of 3-(Tetrahydropyridinyl)indoles: Stereoselective Synthesis of Novel Pentacyclic Ring Systems (1998) (8)
- Molecular biology: Distinctions in acetylcholine receptor activity (1986) (8)
- Determination of the serum iron-binding capacity (1965) (7)
- Towards a high-affinity allosteric enhancer at muscarinic M1 receptors (2002) (6)
- Acetylcholine release and muscarinic receptors in cortical synaptosomes from epileptic rats (1981) (6)
- Two Drug Binding Sites on Muscarinic Receptors (1986) (6)
- Cell-free protein synthesis and interferon action: protein kinase(s) and an oligonucleotide effector, pppA2'p5'A2'p5'A. (1979) (5)
- Muscarinic acetylcholine receptors: structure, function subtypes and therapeutic perspectives. (1987) (5)
- The value of proton relaxation measurements in the study of aqueous phospholipid dispersions (1971) (5)
- Principles and Methods in Receptor Binding (1985) (5)
- Solid-state and solution structures of fluorocholine and some analogues: nuclear magnetic resonance and X-ray studies (1980) (4)
- Allosteric Regulation of Binding and Function at GCPRS (2004) (4)
- Differences in the Agonist Binding Properties of Muscarinic Receptor Subpopulations in the Rat Cerebral Cortex and Myocardium (1986) (4)
- Drug receptors and their effectors (1981) (3)
- Ionic perturbation of agonist binding to brain muscarinic receptors [proceedings]. (1979) (3)
- Subtypes of muscarinic receptors : proceedings of the Seventh International Symposium on Subtypes of Muscarinic Receptors, November 12-15, 1996, Vienna, Virginia, USA (1997) (3)
- Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (3)
- Muscarinic Cholinergic Receptor Localization by Radiohistochemistry (1981) (3)
- Muscarinic receptors: biochemical studies. (1977) (2)
- Application of site-directed mutagenesis to the location of the gallamine binding site on muscarinic receptors (1995) (2)
- Binding properties of reconstituted muscarinic receptors in the absence of G-proteins (1989) (2)
- Interactions of peptides derived from the C-fragment of beta-lipotropin with brain opiate receptors [proceedings]. (1976) (2)
- “Binding States” of Muscarinic Receptors (1981) (2)
- Strategy in Receptor Binding Studies (1984) (2)
- Muscarinic receptors: ionic perturbation of the binding properties [proceedings]. (1977) (2)
- SOLUBILISATION OF THE MUSCARINIC RECEPTOR IN CHAPSO: A COMPARISON WITH THE RECEPTOR IN MEMBRANES AND IN DIGITONIN SOLUTION (1987) (2)
- Synthesis of novel pentacyclic carbazoles as muscarinic allosteric agents (1997) (1)
- The theory, methods and relevance of muscarinic receptor binding studies. (1982) (1)
- Magnetic-Resonance Studies of the Molecular Motion of Lipids in Bilayers and Membranes (1973) (1)
- Subtypes of muscarinic receptors IV. Proceedings of the Fourth International Symposium on Subtypes of Muscarinic Receptors. 20-22 July 1989, Wiesbaden, FRG. (1989) (1)
- TEMPERATURECOEFFICIENTSOF AFFINITYCONSTANTS FOR THE BINDINGOF ANTAGONISTSTO MUSCARINICRECEPTORS IN THE RAT CEREBRALCORTEX (1979) (1)
- Wheel on the sweet smell of success. (1991) (1)
- Proceedings of the International Symposium on Subtypes of Muscarinic Receptors (4th), Held in Wiesbaden (Germany, F.R.) on 20-22 July 1989 (1990) (1)
- Proceedings of the Annual Symposium on Subtypes of Muscarinic Receptors (6th) Held in Fort Lauderdale, Florida on 9-12 November 1994. (1995) (0)
- Effects of p-chloromercuribenzoate on muscarinic receptor binding in rat brain [proceedings]. (1980) (0)
- iron-binding capacity (2004) (0)
- Intramolecular Diels—Alder Reactions of 3-(Tetrahydropyridinyl)indoles: Stereoselective Synthesis of Novel Pentacyclic Ring Systems. (1998) (0)
- Recent Advances in Muscarinic Receptor Pharmacology & Therapeutics (2008) (0)
- A NUCLEAR MAGNETIC RESONANCE INVESTIGATION OF THE CONFORMATION OF NICOTINAMIDE MONONUCLEOTIDE IN AQUEOUS SOLUTION (1975) (0)
- Muscarinic acetylcholine receptors: location of the ligand binding site (1987) (0)
- Sobs Annual Report | | 2008 80 Primary (0)
- SOLID-STATE AND SOLUTION STRUCTURES OF FLUOROCHOLINE AND SOME ANALOGS: NUCLEAR MAGNETIC RESONANCE AND X-RAY STUDIES (1981) (0)
- Allosteric Interactions in Receptor Binding Studies (1984) (0)
- Interactions ofpeptides derived fromtheC-fragment of,B-lipotropin withbrain opiate receptors (1976) (0)
- Proceedings of the International Symposium on Subtypes of Muscarinic Receptors (5th), Held in Newport Beach, California, October 22-24, 1992. (1993) (0)
- Distinctions in acetylcholine receptor activity. (1986) (0)
- The relation of receptor-binding studies to receptor function. (1984) (0)
- Analysis of Lipid Conformation and Biosynthesis by Nuclear Resonance spectroscopy (1974) (0)
- Antibodies to a Covalent Antagonist used to Isolate the Muscarinic Cholinergic Receptor from Rat Brain (1984) (0)
- Subject Index, Vol. 37 (Suppl 1), 1988 (1988) (0)
- QUNATITATION OF ALLOSTERIC INTERACTIONS (1996) (0)
- 3‐(Tetrahydropyridinyl)indoles. (1996) (0)
- Classification of antimuscarinic substances. Round table discussion. (1982) (0)
- Molecular pharmacology of muscarinic receptor subtypes (1992) (0)
- SOLUBILIZATION AND CHARACTERIZATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS (1984) (0)
- Solubilization andcharacterization ofhigh andlow affinity pirenzepine binding sites fromratcerebral cortex (1985) (0)
- Proceedings of the International Symposium on Subtypes of Muscarinic Receptors 2 (2nd) Held in Boston, Massachusetts on August 22-24 1985 (1986) (0)
- CALCULATION OF DIPOLAR NUCLEAR MAGNETIC RELAXATION TIMES IN MOLECULES WITH MULTIPLE INTERNAL ROTATIONS PART 2, THEORETICAL RESULTS FOR ANISOTROPIC OVER-ALL MOTION OF THE MOLECULE, AND COMPARISON WITH (13)C RELAXATION TIMES IN N-ALKANE (1974) (0)
- Reviewer Acknowledgments (2009) (0)
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