Norman R. La Jolla Klinman | Academic Influence

Why Is Norman R. La Jolla Klinman Influential?

Norman R. La Jolla Klinman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. (1980) (584)
Hybrid plasmacytoma production: fusions with adult spleen cells, monoclonal spleen fragments, neonatal spleen cells and human spleen cells. (1978) (300)
THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS (1972) (275)
Antigen-independent changes in naive CD4 T cells with aging (1996) (248)
Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations (1989) (221)
In vitro tolerance induction of neonatal murine B cells. (1976) (207)
B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. (1999) (190)
General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. (1969) (142)
The "clonal selection hypothesis" and current concepts of B cell tolerance. (1996) (140)
Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell. (1975) (128)
Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C (1995) (124)
Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level (1975) (123)
The B Cell Specificity Repertoire: Its Relationship to Definable Subpopulations (1975) (120)
AN ASSAY METHOD FOR DISULFIDE GROUPS BY FLUORESCENCE QUENCHING. (1964) (112)
The B‐cell biology of aging (1997) (108)
In vitro tolerance induction of neonatal murine B cells (1976) (103)
Assessing B cell diversification by antigen receptor and precursor cell analysis. (1976) (100)
Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains. (1998) (98)
The expression of the Ig H chain repertoire in developing bone marrow B lineage cells. (1991) (96)
In vitro tolerance induction of bone marrow cells: a marker for B cell maturation. (1977) (95)
The characterization fo the B-cell repertoire specific for the 2,4- dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice (1975) (94)
The B-cell clonotype repertoire. (1978) (89)
Tolerance susceptibility of newly generating memory B cells. (1991) (87)
Late acquisition of a germ line antibody specificity (1976) (81)
Altered VH gene segment utilization in the response to phosphorylcholine by aged mice. (1989) (80)
Equine anti-hapten antibody-V the non-precipitability of bivalent antibody (1967) (79)
Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells (1982) (79)
Allogeneic carrier-specific enhancement of hapten-specific secondary B- cell responses (1976) (77)
Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. (1991) (76)
B-cell development. (1981) (75)
Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers (1992) (75)
Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype. (1977) (75)
Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta. (2003) (75)
Antigen responsiveness of the mature and generative B cell populations of aged mice (1983) (73)
The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C mice. (1975) (71)
The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice (1978) (69)
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses (1975) (68)
Antibody with homogeneous antigen binding produced by splenic foci in organ culture. (1967) (68)
Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. (1995) (65)
Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice. (1979) (65)
Equine Anti-Hapten Antibody: III. The Comparative Properties of γG- and γA-Antibodies (1966) (60)
The stimulation of splenic foci in vitro. (1971) (59)
Tolerance as an active process (1980) (59)
The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire (1977) (57)
Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype. (1981) (54)
A selective increase in the generation of phosphorylcholine-specific B cells associated with aging. (1986) (49)
The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs mature primary B cells. (1986) (49)
Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations (1976) (48)
Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes. (1986) (46)
MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY (1973) (45)
The interplay of evolution and environment in B-cell diversification. (1977) (44)
The clonotype repertoire of B cell subpopulations. (1988) (42)
Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire (1983) (42)
Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. (1995) (42)
OVERLAP STIMULATION OF PRIMARY AND SECONDARY B CELLS BY CROSS-REACTING DETERMINANTS (1973) (41)
Recovery of antibody activity upon reoxidation of completely reduced polyalanyl heavy chain and its Fd fragment derived from anti-2,4-dinitrophenyl antibody. (1968) (39)
Analysis of the primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) responsive B cells in BALB/C and B10.D2 mice. (1980) (38)
Susceptibility to in vitro tolerance induction of adult B cells from mice with an X-linked B-cell defect (1980) (37)
Genetic and temporal control of neonatal antibody expression (1983) (36)
THE SECONDARY IMMUNE RESPONSE TO A HAPTEN IN VITRO (1971) (36)
T-cell and B-cell responses to viral antigens at the clonal level. (1983) (35)
Purification and analysis of "monofocal" antibody. (1971) (35)
Enumeration and analysis of antibody-forming cell precursors in the neonatal mouse. (1973) (35)
HAPTEN-SPECIFIC STIMULATION OF SECONDARY B CELLS INDEPENDENT OF T CELLS (1973) (34)
Membrane and metabolic requirements for tolerance induction of neonatal B cells. (1984) (33)
Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response (1982) (33)
Evolution and the molecular basis of somatic hypermutation of antigen receptor genes. (2001) (32)
A microtest radioimmunoassay for noncytotoxic tumor-specific antibody to cell-surface antigens. (1973) (32)
Isoelectric analysis of neonatal monofocal antibody. (1973) (32)
The role of antibody bivalence in the neutralization of bacteriophage. (1967) (31)
Cellular Response to Partial Hepatectomy (1963) (31)
Immature B cells as the target for in vivo tolerance induction. (1981) (31)
The frequency and fine specificity of B cells responsive to (4-hydroxy-3-nitrophenyl)acetyl in aged mice. (1986) (31)
Equine antihapten antibody II. The γG(7Sγ) components and their specific interaction (1965) (30)
B cell repertoire diversity to PR8 influenza virus does not decrease with age. (1984) (29)
The generation of memory B cells. (1992) (28)
BIOGRAPHY OF THE B CELL (1974) (28)
Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides. (1985) (26)
Valence and Affinity of Equine Nonprecipitating Antibody to a Haptenic Group (1964) (25)
Defining the heterogeneity of anti-tumor antibody responses. (1976) (24)
The cellular origins of memory B cells. (1997) (24)
B cell repertoire ontogeny: heritable but dissimilar development of parental and F1 repertoires. (1981) (23)
Individual antigen-specific T lymphocytes: helper function in enabling the expression of multiple antibody isotypes (1978) (23)
Regain of homogeneous binding activity after recombination of chains of "mono- focal" antibody. (1971) (22)
The murine B cell repertoire responsive to an influenza-infected syngeneic cell line. (1981) (22)
Differences in antibody repertoires for (4-hydroxy-3-nitrophenyl)acetyl (NP) in splenic vs immature bone marrow precursor cells. (1985) (22)
Pre-B Cell Receptor-Mediated Selection of Pre-B Cells Synthesizing Functional μ Heavy Chains (1998) (21)
The generation of B-cell memory: a working hypothesis. (1990) (21)
Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n (1980) (21)
B cell repertoire diversification precedes immunoglobulin receptor expression (1983) (19)
In Vitro Analysis of the Generation and Propagation of Memory B Cells (1996) (19)
ROLE OF INORGANIC PHOSPHATE IN THIOSULFATE METABOLISM BY THIOBACILLUS THIOPARUS (1960) (17)
Regulation of B cell tolerance by murine gangliosides. (1982) (17)
Surface IgG-bearing cells retain the capacity to secrete IgM. (1986) (17)
Expression of specific clones during B cell development. (1975) (16)
Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes. (1989) (15)
B cell repertoire diversity in athymic mice (1980) (13)
The Specificity Repertoire of Prereceptor and Mature B Cells a (1983) (13)
Carrier independent T cell helper effects in antigenic stimulation. (1973) (13)
Analysis of the humoral immune response to influenza virus in vitro. (1976) (13)
Multiple B cell stimulation by individual antigen‐specific T lymphocytes (1981) (11)
Affinity labeling of equine anti-beta-lactoside antibodies. (1967) (11)
The acquisition of b-cell competence and diversity. (1976) (10)
EQUINE ANTIHAPTEN ANTIBODY II. THE GAMMA-G(7S-GAMMA) COMPONENTS AND THEIR SPECIFIC INTERACTION. (1965) (10)
Is tolerance the result of engaging surface Ig of B cells in cycle? (1987) (10)
Aging associated changes in the generation and development of B cell memory. (1995) (8)
Specific immunoglobulin cDNA clones produced from hybridoma cell lines and murine spleen fragment cultures by 3SR amplification. (1994) (7)
Reply: developmental selection complements evolutionary determination (1991) (7)
Defining the B-Cell Repertoire with Hybridomas Derived from Monoclonal Fragment Cultures (1980) (7)
Tolerance and B cell repertoire establishment. (1985) (6)
Ia antigens on murine thymocytes: detection by cellular radioimmunoassay. (1977) (6)
B lymphocytes in the immune response : functional, developmental, and interactive properties : proceedings of the second International Conference on B Lymphocytes in the Immune Response, Scottsdale, Arizona, U.S.A., October 18-22, 1980 (1981) (5)
Selection in the expression of functionally distinct B-cell subsets. (1994) (5)
Comparison of immature B-cell populations in neonates and adults. (1984) (4)
EQUINE ANTIHAPTEN ANTIBODY (1964) (4)
Equine anti-hapten antibody. 3. The comparative properties of gamma G- and gammaA-antibodies. (1966) (4)
Dependence of antilymphocyte serum effectiveness on degree of donor-recipient histocompatibility. (1972) (4)
Nonsequential expression of multiple immunoglobulin classes by isola- ted phosphorylcholine specific clones. Abstr. (1975) (4)
Self-Nonself Discrimination by Precursors of Memory B Cells (1989) (4)
The Characterization of Monofocal Antibodies (1971) (3)
Repertoire expression in surface immunoglobulin-negative bone marrow B cell precursors. (1987) (3)
Antibody responses to synthetic peptides corresponding to antigenic determinants on mouse cytochrome. Abstr. (1982) (3)
Interrelating B cell subpopulations and environmental regulation with the expression of three tiers of repertoire diversity. (1992) (3)
Interaction of gangliosides with B cells in splenic fragment cultures. (1984) (3)
B cell tolerance (1985) (2)
Repertoire diversification of primary vs memory B cell subsets. (1998) (2)
The parameters of B-cell inactivation in transgenic mice vs classical model studies. (1992) (2)
Delineation of primary b cell subpopulations by size fractionation. Abstr. (1976) (1)
Genetic and Environmental Control of B-Cell Idiotype Expression (1984) (1)
The frequency of ars- and dansyl-specific b cells in neonatal and adult mice. Abstr. (1976) (1)
The use of Bayesian analysis of PCR-derived genomic DNA sequences to enable a biologically relevant interpretation of immunoglobulin variable region gene expression. (1993) (1)
An experimental system for determining the influence of microgravity on B lymphocyte activation and cell fusion. (1992) (1)
The Use of the Splenic Focus Assay to Study B Cell Tolerance (1993) (1)
Diversity 1990 (1990) (1)
Characterization of antibody produced by splenic foci in vitro. Abstr. (1970) (1)
INDIVIDUAL ANTIGEN-SPECIFIC T LYMPHOCYTES methodology of the B-cell splenic focus analysis developed to s tudy ind iv idua l B-cell an t i body responses in vitro (2003) (0)
ANTIGENIC STIMULATION OF CLONAL PRECURSOR CELLS mechanism of antigenic stimulation in the secondary response (0)
When Two-Dimensional Structure Led the Way (2004) (0)
Changes in Naive CD 4 T Cells (2002) (0)
SUSCEPTIBILITY T O I N V ITRO T OLERANCE I NDUCTION OF A DULT B CELLS F ROM MICE W ITH A N X -LINKED B -CELL D EFECT* (1980) (0)
Introduction: B-cell memory (1997) (0)
Mono clonal rat anti murine immuno globulin reagents (1980) (0)
Polyspecific binding molecules and their use (1999) (0)
In Vitro Analysis of Somatically Mutated B-Cells (1993) (0)
Introduction: B Cell Ontogeny and Repertoire Expression Parts I and II (1992) (0)
Ir Gene Regulation at the Single Cell Level (1978) (0)
Production of antibodies of monoclonal specificity without the use of hybridoma cell lines (1994) (0)
Defining the immune mechanism with monoclonal antibodies (1981) (0)
The regulation of expression of b cell clones. Abstr. (1975) (0)
domas with ant ibody-producing cells derived from dinitrophenyl (DNp)l-responsive neonatal B cells. The use of these monoclonal antibodies and antiidiotypic reagents has confirmed several previously established basic tenants of neonatal responses (21). In addition, the availability of large quantiti (2003) (0)
Functional Maturation of B Cell Repertoire Expression (1987) (0)
Analysis of balb/c non-t15 monoclonal anti-pc antibodies. Abstr. (1978) (0)
Differences in the capacity of neonatal and adult b lymphocytes to be tolerized in vitro. (1976) (0)
Non-h-2 directed immunoregulation of primary b-cell responses. Abstr. (1977) (0)
RNA to DNA Polymerase Formation in Mice Expressing Antisense Maturation but Intact Germinal Center Hypermutation and Impaired Affinity Decreased Frequency of Somatic (2001) (0)
Alterations in B Cells and Antibodies of Aged Mice (1990) (0)
The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. 1972. (2005) (0)
Pillars Article: The Mechanism of Antigenic Stimulation of Primary and Secondary Clonal Precursor Cells. J. Exp. Med., 1972, 136: 241–260 (2005) (0)
B cell development : proceedings of an Abbott-Ortho-UCLA symposium held at Taos, New Mexico, January 31-February 7, 1988 (1988) (0)
Decreased B Cell Generation Both Increased B Cell Longevity and B Cell Maintenance in Aged Mice Reflects (1999) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Norman R. La Jolla Klinman?

Norman R. La Jolla Klinman is affiliated with the following schools: