Nabil Seidah

Q: What Schools Are Affiliated With Nabil Seidah

Nabil Seidah is affiliated with the following schools: Harvard University, Université Laval, Humboldt University of Berlin, Université de Montréal, McGill University, University of Ottawa, Cairo University, Royal Postgraduate Medical School, University of Manitoba, Georgetown University

Nabil Seidah's AcademicInfluence.com Rankings

Nabil Seidah

Biology

#3973

World Rank

#5999

Historical Rank

Molecular Biology

#339

World Rank

#345

Historical Rank

Biochemistry

#423

World Rank

#503

Historical Rank

biology Degrees

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Biology

Nabil Seidah's Degrees

PhD Biochemistry McGill University
Bachelors Biochemistry McGill University

Why Is Nabil Seidah Influential?

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According to Wikipedia, Nabil G. Seidah, is a Canadian Québécois scientist. Born in Egypt, he was educated at Cairo University, and subsequently at Georgetown University where he obtained his Ph.D. in 1973. He emigrated to Canada and has been working at the Clinical Research Institute of Montreal since 1974. He is the director of the laboratory of Biochemical Neuroendocrinology. He discovered and cloned seven of the nine known enzymes belonging to the convertase family. During this period, he also greatly contributed to demonstrating that the proteolysis by the proprotein convertases is a wide mechanism that also concerns “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. In 2003, he discovered PCSK9 and showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, likely because of a gain of function related to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor . He has since worked on the elucidation of the functions and mechanisms of action of PCSK9 and PCSK7 both in cells and in vivo, and is developing specific PCSK9 and PCSK7 inhibitors/silencers.

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Nabil Seidah's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia (2003) (2613)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (2005) (1598)
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade (2020) (1392)
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation (2003) (1062)
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides 1 Published on the World Wide Web on 17 August 1999. 1 (1999) (786)
The Notch1 receptor is cleaved constitutively by a furin-like convertase. (1998) (752)
The biology and therapeutic targeting of the proprotein convertases (2012) (667)
Automated design of ligands to polypharmacological profiles (2012) (651)
Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia (2004) (596)
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. (1991) (567)
Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor* (2001) (538)
NARC-1/PCSK9 and Its Natural Mutants (2004) (461)
PCSK9: A Key Modulator of Cardiovascular Health (2014) (452)
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. (1990) (425)
The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2* (2008) (399)
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. (1994) (378)
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2 (2005) (370)
Delta-1 Activation of Notch-1 Signaling Results inHES-1 Transactivation (1998) (365)
Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration (2008) (360)
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases (1996) (358)
Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons (1999) (351)
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P (2001) (325)
Endothelium-Restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction (2004) (323)
The activation and physiological functions of the proprotein convertases. (2008) (322)
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. (1996) (292)
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. (1999) (292)
Eukaryotic protein processing: endoproteolysis of precursor proteins. (1997) (282)
The Proprotein Convertase (PC) PCSK9 Is Inactivated by Furin and/or PC5/6A (2006) (266)
Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding (2001) (260)
Role of prohormone convertases in the tissue-specific processing of proglucagon. (1996) (249)
The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR (2007) (231)
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme. (2001) (230)
Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation (2009) (229)
Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue (2011) (228)
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. (2003) (224)
Proprotein convertases: lessons from knockouts (2006) (223)
Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters (2010) (220)
A new method for measurement of total plasma PCSK9: clinical applications (2010) (216)
cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. (1993) (215)
Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models (2018) (213)
Precursor convertases in the secretory pathway, cytosol and extracellular milieu. (2002) (210)
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. (2002) (208)
A Serine Protease Inhibitor Prevents Endoplasmic Reticulum Stress-induced Cleavage but Not Transport of the Membrane-bound Transcription Factor ATF6* (2003) (205)
Post-translational processing of b -secretase (BACE) and its ectodomain shedding: the pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid A b production (2000) (199)
ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL (2004) (191)
A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo (2010) (189)
Precursor Convertases: An Evolutionary Ancient, Cell‐Specific, Combinatorial Mechanism Yielding Diverse Bioactive Peptides and Proteins (1998) (188)
Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice (2012) (188)
Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. (1984) (186)
Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA. (1987) (184)
PCSK9‐deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities (2010) (183)
Neuroendocrine secretory protein 7B2: structure, expression and functions. (2001) (182)
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1) (2013) (180)
Impaired fertility in mice deficient for the testicular germ-cell protease PC4. (1997) (180)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD (2010) (179)
Inhibition of Proprotein Convertases Is Associated with Loss of Growth and Tumorigenicity of HT-29 Human Colon Carcinoma Cells (2001) (179)
Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor* (2015) (175)
Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. (1993) (172)
Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain (2000) (171)
Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives (1992) (161)
The proprotein convertases are potential targets in the treatment of dyslipidemia (2007) (159)
Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts* (2009) (157)
PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor’s role[S] (2016) (156)
The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions* (2013) (156)
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments (1996) (155)
Identification of a biologically active circulating form of rat atrial natriuretic factor. (1985) (152)
The proprotein convertases, 20 years later. (2011) (149)
In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9* (2010) (146)
Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels* (2008) (146)
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression (2009) (145)
The Pore-forming Toxin Proaerolysin Is Activated by Furin* (1998) (144)
Pro‐protein convertase gene expression in human breast cancer (1997) (140)
Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia. (1978) (140)
The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PC1, PC2/7B2, POMC and the Novel Enzyme SKI‐1 (1999) (140)
Proprotein Convertases (2011) (139)
Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. (2012) (135)
Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Proteolytic Processing by Subtilase SKI-1 (2003) (135)
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. (2013) (133)
Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 (2001) (132)
The Prosegments of Furin and PC7 as Potent Inhibitors of Proprotein Convertases (1999) (130)
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin. (1993) (130)
The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor. (1987) (128)
Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin. (1976) (127)
Neurotrophin-3 Sorts to the Constitutive Secretory Pathway of Hippocampal Neurons and Is Diverted to the Regulated Secretory Pathway by Coexpression with Brain-Derived Neurotrophic Factor (2000) (127)
Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors (2008) (127)
Proteases and posttranslational processing of prohormones: a review. (1983) (127)
Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1. (1992) (126)
Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. (1983) (123)
From β-lipotropin to β-endorphin and 'pro-opio-melanocortin' (1979) (122)
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. (1997) (120)
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. (2008) (119)
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. (2001) (118)
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. (2008) (118)
Gene Inactivation of PCSK9 Reduces Atherosclerosis in Mice (2012) (114)
NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: Identification, radioimmunoassay and half-life (1988) (113)
The Proprotein Convertase PC5A and a Metalloprotease Are Involved in the Proteolytic Processing of the Neural Adhesion Molecule L1* (2003) (111)
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. (2015) (110)
Furin-Like Proprotein Convertases Are Central Regulators of the Membrane Type Matrix Metalloproteinase–Pro-Matrix Metalloproteinase-2 Proteolytic Cascade in Atherosclerosis (2005) (108)
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. (2011) (108)
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400396-JLR200 (2005) (108)
Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors. (1984) (106)
Implication of the proprotein convertase NARC‐1/PCSK9 in the development of the nervous system (2006) (105)
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. (1999) (105)
Tissue distribution and molecular forms of a novel pituitary protein in the rat. (1984) (104)
Identification of the Paired Basic Convertases Implicated in HIV gp160 Processing Based on in Vitro Assays and Expression in CD4+ Cell Lines* (1996) (104)
Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. (2004) (104)
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7. (2000) (104)
Biosynthesis and Cellular Trafficking of the Convertase SKI-1/S1P (2002) (104)
Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation (2012) (101)
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate (2008) (101)
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases. (2005) (100)
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum. (2013) (100)
Complete amino acid sequence of BSP-A3 from bovine seminal plasma. Homology to PDC-109 and to the collagen-binding domain of fibronectin. (1987) (100)
The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1* (2000) (98)
Cellular Localization of the Prohormone Convertases in the Hypothalamic Paraventricular and Supraoptic Nuclei: Selective Regulation of PC1 in Corticotrophin-Releasing Hormone Parvocellular Neurons Mediated by Glucocorticoids (1997) (97)
The proprotein convertases and their implication in sterol and/or lipid metabolism (2006) (97)
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men (2011) (93)
Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis (2016) (92)
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. (2000) (92)
Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2. (1993) (90)
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity. (2003) (89)
Plasma PCSK9 levels correlate with cholesterol in men but not in women. (2007) (89)
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. (1990) (89)
Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases. (1996) (88)
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. (2012) (88)
Pro-protein convertases of subtilisin/kexin family. (1994) (88)
Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase* (2005) (88)
Dual regulation of the LDL receptor--some clarity and new questions. (2005) (87)
What lies ahead for the proprotein convertases? (2011) (87)
Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. (2012) (87)
7B2 Is a Specific Intracellular Binding Protein of the Prohormone Convertase PC2 (1995) (87)
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates. (1987) (86)
Biosynthesis and Enzymatic Characterization of Human SKI-1/S1P and the Processing of Its Inhibitory Prosegment* (2000) (86)
Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse (2006) (86)
The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase. (1994) (86)
α1-Antitrypsin Portland Inhibits Processing of Precursors Mediated by Proprotein Convertases Primarily within the Constitutive Secretory Pathway* (1997) (86)
Processing of secretogranin II by prohormone convertases: Importance ofPC1 in generation of secretoneurin (1995) (85)
Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining. (2012) (85)
The Regulated Cell Surface Zymogen Activation of the Proprotein Convertase PC5A Directs the Processing of Its Secretory Substrates* (2008) (84)
In Vitro Characterization of the Novel Proprotein Convertase PC7* (1997) (84)
Structure-activity relationships of atrial natriuretic factor (ANF). I. Natriuretic activity and relaxation of intestinal smooth muscle. (1984) (83)
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. (1993) (82)
Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteins a (1993) (81)
Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor (*) (1995) (80)
Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases* (1997) (79)
The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9 (2017) (79)
APOE p.Leu167del mutation in familial hypercholesterolemia. (2013) (78)
The Influence of PCSK9 Polymorphisms on Serum Low-Density Lipoprotein Cholesterol and Risk of Atherosclerosis (2010) (78)
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases. (1996) (78)
Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. (1995) (78)
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases (2005) (77)
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice (2013) (74)
Proparathyroid Hormone Is Preferentially Cleaved to Parathyroid Hormone by the Prohormone Convertase Furin (1995) (74)
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides. (2001) (74)
Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family. (1996) (74)
Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. (1996) (74)
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies. (2013) (73)
Two Activation States of the Prohormone Convertase PC1 in the Secretory Pathway* (1997) (73)
Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity. (1981) (73)
Apolipoprotein A-I binds to a family of bovine seminal plasma proteins. (1989) (73)
Gene structure and chromosomal localization of plasma kallikrein. (1991) (73)
PCSK9 is phosphorylated by a Golgi casein kinase‐like kinase ex vivo and circulates as a phosphoprotein in humans (2008) (72)
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family. (2000) (72)
Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor. (1987) (71)
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus (2004) (71)
Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia. (1979) (70)
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke[S] (2011) (70)
Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity. (1984) (70)
Complete amino acid sequence of Shigella toxin B-chain. A novel polypeptide containing 69 amino acids and one disulfide bridge. (1986) (69)
Surface expression of precursor N-cadherin promotes tumor cell invasion. (2010) (69)
Effects of the Prosegment and pH on the Activity of PCSK9 (2010) (69)
Proteolytic Processing of Chromogranin B and Secretogranin II by Prohormone Convertases (1998) (69)
Isolation from human seminal plasma of an abundant 16-kDa protein originating from the prostate, its identification with a 94-residue peptide originally described as beta-inhibin. (1987) (69)
Molecular cloning and expression of the ovine testicular follicle stimulating hormone receptor (1993) (69)
Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate. (1987) (68)
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System (2015) (68)
The family of pro-hormone and pro-protein convertases. (1993) (67)
PCSK9 as a therapeutic target of dyslipidemia (2009) (66)
Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells. (1993) (66)
The Proprotein Convertase SKI-1/S1P (2006) (66)
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome (2011) (66)
The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 Protein Is Needed for the Extracellular Low-density Lipoprotein Receptor (LDLR) Degradation Pathway* (2012) (66)
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells (2007) (65)
Structure-activity relationships of atrial natriuretic factor (ANF). II. Effect of chain-length modifications on vascular reactivity. (1985) (64)
Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes. (2013) (64)
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1. (2007) (63)
Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels (2013) (63)
Immunocytochemical localization of a novel pituitary protein (7B2) within the rat brain and hypophysis. (1985) (62)
Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin (2013) (61)
Loss- and Gain-of-function PCSK9 Variants (2012) (61)
A rapid high-performance liquid chromatography purification method of lodinated polypeptide hormones (1980) (61)
PCSK9 as a therapeutic target of dyslipidemia. (2009) (61)
Primary structure determination of Escherichia coli heat-stable enterotoxin of porcine origin. (1983) (61)
In Vitro Cleavage of Internally Quenched Fluorogenic Human Proparathyroid Hormone and Proparathyroid-related Peptide Substrates by Furin (1998) (61)
Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo. (1996) (60)
Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10* (2011) (60)
Corticotropin releasing factor (CRF): effects on the release of pro-opiomelanocortin (POMC)-related peptides by human anterior pituitary cells in vitro. (1982) (60)
Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160 (1997) (60)
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. (2003) (59)
Cellular Localization and Role of Prohormone Convertases in the Processing of Pro-melanin Concentrating Hormone in Mammals* (1999) (58)
Development of Protein-based Inhibitors of the Proprotein of Convertase SKI-1/S1P (2004) (58)
Dysregulation of dynorphins in Alzheimer disease (2007) (58)
Content of beta-LPH and its fragments (including endorphins) in anterior and intermediate lobes of the bovine pituitary gland. (1978) (57)
Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies (2019) (57)
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. (2005) (57)
Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin. (1981) (57)
Region specific expression of furin mRNA in the rat brain (1993) (56)
Processing Specificity and Biosynthesis of the Drosophila melanogaster Convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2 (*) (1995) (56)
Inhibitory Specificity and Potency of proSAAS-derived Peptides toward Proprotein Convertase 1* (2001) (56)
Structure-Function Analysis of the Prosegment of the Proprotein Convertase PC5A* (2003) (55)
SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth. (2012) (54)
The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. (2011) (54)
Proteolytic processing of human prorenin in renal and non-renal tissues. (1994) (54)
Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study (2002) (53)
CNS distribution of a novel pituitary protein ‘7B2’: localization in secretory and synaptic vesicles (1986) (53)
Pro-opiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes. (2000) (53)
Proprotein Convertase Activity Contributes to the Processing of the Alzheimer's β‐Amyloid Precursor Protein in Human Cells: Evidence for a Role of the Prohormone Convertase PC7 in the Constitutive ‐Secretase Pathway (1999) (52)
Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin (1984) (52)
The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation. (1981) (52)
A Predicted α-Helix Mediates Targeting of the Proprotein Convertase PC1 to the Regulated Secretory Pathway* (2000) (51)
The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. (1997) (51)
The effect of insulin on circulating PCSK9 in postmenopausal obese women. (2014) (50)
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions (2018) (50)
In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia. (1978) (49)
cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. (2009) (49)
The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide. (1981) (48)
Measurement of N-terminal (1-76) of human proopiomelanocortin in human plasma: correlation with adrenocorticotropin. (1983) (48)
Sequence homologies between tonin, nerve growth factor γ-subunit, epidermal growth factor-binding protein and serine proteases (1981) (48)
Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system (2000) (48)
Effect of N-terminal portion of pro-opiomelanocortin on aldosterone release by human adrenal adenoma in vitro. (1981) (48)
Enzymic characterization in vitro of recombinant proprotein convertase PC4. (1999) (47)
Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes* (2013) (47)
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. (2014) (47)
Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes. (1989) (46)
Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis (1984) (46)
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other* (2015) (46)
β-endorphin induced akinesia in rats: Effect of apomorphine and α-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia (1977) (45)
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region). (1991) (45)
New developments in proprotein convertase subtilisin–kexin 9's biology and clinical implications (2016) (45)
Gene organization of the mouse pro-hormone and pro-protein convertase PC1. (1994) (44)
PC5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC5-transfected PC12 Cells* (1998) (44)
Identification of the Released form of Atrial Natriuretic Factor by the Perfused Rat Heart (1986) (44)
The cDNA sequence of the human pro-hormone and pro-protein convertase PC1. (1992) (44)
PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S] (2015) (43)
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor. (1995) (43)
Structure-activity relationships of atrial natriuretic factor (ANF). III. Correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells. (1985) (43)
Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry. (2015) (43)
Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death (2012) (42)
Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224 (2017) (42)
Decreased PCSK9 expression in human hepatocellular carcinoma (2015) (42)
Proprotein convertase furin regulates osteocalcin and bone endocrine function (2017) (42)
Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions* (2014) (42)
Biosynthesis of beta-endorphin by the neurointermediate lobes from rats treated with morphine or alcohol. (1981) (42)
Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms. (1994) (41)
Large Dense‐Core Vesicles in Rat Adrenal After Reserpine: Levels of mRNAs of Soluble and Membrane‐Bound: Constituents in Chromaffin and Ganglion Cells Indicate a Biosynthesis of Vesicles with Higher Secretory Quanta (1994) (41)
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. (2008) (41)
PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism. (2015) (41)
The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes. (1997) (41)
The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol (2015) (41)
N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface. (2000) (41)
Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia (2016) (40)
Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. (1995) (40)
Tetraphenylborate adsorption onto an artificial ultrathin membrane (1974) (40)
β‐Amyloid protein converting enzyme 1 and brain‐specific type II membrane protein BRI3: binding partners processed by furin (2005) (40)
A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates. (1986) (40)
Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia. (1979) (40)
Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. (2013) (39)
Selective cleavage of human ACTH, beta-lipotropin, and the N-terminal glycopeptide at pairs of basic residues by IRCM-serine protease 1. Subcellular localization in small and large vesicles. (1986) (39)
Disruption of Proprotein Convertase 1/3 (PC1/3) Expression in Mice Causes Innate Immune Defects and Uncontrolled Cytokine Secretion* (2012) (39)
Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: Brain concentrations in controls and patients with Alzheimer's disease (1987) (38)
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides (2001) (38)
Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization* (2010) (38)
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7 (2008) (38)
Isolation and purification of Escherichia coli heat-stable enterotoxin of porcine origin. (1982) (37)
Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age* (2015) (37)
Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates High-Density Lipoprotein Cholesterol Levels (2009) (37)
Molecular Characterization of the Processing of Arenavirus Envelope Glycoprotein Precursors by Subtilisin Kexin Isozyme-1/Site-1 Protease (2012) (37)
The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates (1995) (37)
Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice (2019) (37)
The RGD Motif and the C-terminal Segment of Proprotein Convertase 1 Are Critical for Its Cellular Trafficking but Not for Its Intracellular Binding to Integrin α5β1 * (1999) (37)
PreproTRH(178-199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling. (2001) (37)
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. (2007) (36)
Homologous IRCM-Serine Protease 1 from pituitary, heart atrium and ventricle: A common pro-hormone maturation enzyme? (1986) (36)
Annexin A2 Reduces PCSK9 Protein Levels via a Translational Mechanism and Interacts with the M1 and M2 Domains of PCSK9* (2014) (36)
Regional distribution of a novel pituitary protein (7B2) in the rat brain (1985) (36)
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. (2005) (36)
Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency. (2013) (36)
pH‐induced conformational transitions of a molten–globule–like state of the inhibitory prodomain of furin: Implications for zymogen activation (2001) (35)
PRESENCE OF A PRE‐SEQUENCE (SIGNAL SEQUENCE) IN THE COMMON PRECURSOR TO ACTH AND ENDORPHIN AND THE ROLE OF GLYCOSYLATION IN PROCESSING OF THE PRECURSOR AND SECRETION OF ACTH AND ENDORPHIN * (1980) (35)
Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9 (2017) (35)
The Proprotein Convertase PC7 (2010) (35)
Biosynthesis of beta-endorphin, beta-lipotropin and the putative ACTH-LPH precursor in the frog pars intermedia. (1978) (35)
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases (2005) (34)
The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain. (1982) (34)
Endoproteolytic Activation of &agr;v Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling (2004) (34)
Selective Expression of the Proprotein Convertases Furin, PC5, and PC7 in Proliferating Vascular Smooth Muscle Cells of the Rat Aorta In Vitro (2001) (34)
GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence. (1985) (34)
Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. (2013) (34)
Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor (2018) (34)
A rapid fluorometric assay for the proteolytic activity of SKI‐1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus (2002) (34)
A novel human pituitary peptide containing the γ-MSH sequence (1980) (34)
The multifaceted biology of PCSK9. (2021) (33)
Proprotein convertases and the pathophysiology of human diseases: prospective considerations. (1995) (33)
Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes (2020) (33)
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells. (1998) (33)
Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model (2013) (33)
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi (2005) (32)
In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. (1977) (32)
Effect of chronic morphine treatment on beta-endorphin biosynthesis by the rat neurointermediate lobe. (1981) (32)
Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases (1984) (32)
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity (2022) (32)
Residues unique to the pro‐hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity (1998) (31)
Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. (2009) (31)
Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments. (1980) (31)
Application of the multiple antigenic peptides (MAP) strategy to the production of prophormone convertases antibodies: Synthesis, characterization and use of 8‐branched immunogenic peptides (1995) (31)
Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence. (1980) (31)
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model (2009) (30)
Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor* (2011) (30)
Chemistry and biosynthesis of pro-opiomelanocortin (1981) (30)
Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model. (2004) (30)
A new method for measurement of total plasma PCSK 9 : clinical applications (2009) (30)
Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor. (2004) (30)
Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain. (1983) (30)
In vitro biosynthesis of beta-endorphin in pituitary glands. (1977) (29)
Specific release of a novel pituitary polypeptide, 7B2, from rat anterior pituitary cells in vitro by luteinizing hormone-releasing hormone. (1986) (29)
High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels. (2015) (29)
Protease inhibitors suppress in vitro growth of human small cell lung cancer (1993) (29)
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy (2011) (28)
Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism* (2016) (28)
Proprotein Convertase 2 (2013) (28)
Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors. (1994) (28)
Heparin enhances the furin cleavage of HIV‐1 gp160 peptides (2007) (28)
Neurotrophin-4, Alone or Heterodimerized with Brain-derived Neurotrophic Factor, Is Sorted to the Constitutive Secretory Pathway* (2003) (28)
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis (2005) (28)
Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia. (1980) (28)
Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate. (1988) (27)
Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78). (1979) (27)
Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro‐neurotensin in rat brain (2000) (27)
Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide. (1982) (27)
Maintained PC1 and PC2 expression in the AtT-20 variant cell line 6T3 lacking regulated secretion and POMC: restored POMC expression and regulated secretion after cAMP treatment. (1995) (27)
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication. (2012) (27)
Design and synthesis of novel inhibitors of prohormone convertases. (2009) (27)
Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma. (1988) (27)
Reinvestigation of the disulfide bridge arrangement in human pro-opiomelanocortin N-terminal segment (hNT 1-76). (2009) (27)
Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. (2010) (27)
Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3. (1999) (27)
SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection. (2015) (26)
Proprotein convertases as therapeutic targets. (2008) (26)
Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder (2015) (26)
New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia (2018) (26)
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor). (2019) (26)
Immunological characterization of β-lipotropin fragments (endorphin, β-MSH, and N-fragment) from fish pituitaries (1978) (26)
Corticotropin (ACTH) and the N-terminal fragment of pro-opiomelanocortin are located in the same granules in cells of rat pituitary gland. (1983) (26)
Functional analysis of human PACE4‐A and PACE4‐C isoforms: identification of a new PACE4‐CS isoform (1996) (26)
The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation (2018) (26)
Characterization of β-endorphin immunoreactive peptides in rat pituitary and brain by coupled gel and reversed-phase high-performance liquid chromatography (1983) (26)
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism (2007) (26)
Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus (1997) (25)
The cDNA structure of rat plasma kallikrein. (1989) (25)
cDNA structure and in situ localization of the Aplysia californica pro‐hormone convertase PC2 (1993) (25)
Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein. (1988) (25)
Distribution and Regulation of Proconvertases PC1 and PC2 in Human Pituitary Adenomas (1999) (25)
Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1. (2009) (25)
Elevated expression of proprotein convertases alters breast cancer cell growth in response to estrogen and tamoxifen. (2001) (25)
Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1 (2004) (25)
Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice (2019) (25)
Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (1995) (24)
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors (2022) (24)
Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors. (1988) (24)
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain (2007) (24)
Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7. (2000) (24)
Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain (1999) (24)
Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9* (2015) (24)
Respiratory Distress and Neonatal Lethality in Mice Lacking Golgi α1,2-Mannosidase IB Involved in N-Glycan Maturation* (2007) (24)
Opposite roles of furin and PC5A in N-cadherin processing. (2012) (24)
Processing of Two Forms of the Common Precursor to α‐Melanotropin and β‐Endorphin in the Rat Pars Intermedia (1980) (24)
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis. (2014) (24)
Fragmentation of bovine chromogranin A by plasma kallikrein. (1990) (24)
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained (2018) (23)
A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts. (2015) (23)
Purification and sequence determination of bovine atrial natriuretic factor. (1986) (23)
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation* (2016) (23)
Zebrafish ProVEGF-C Expression, Proteolytic Processing and Inhibitory Effect of Unprocessed ProVEGF-C during Fin Regeneration (2010) (23)
Prohormone Convertases in Mouse Submandibular Gland: Co-localization of Furin and Nerve Growth Factor (1997) (23)
Tissue-specific expression of the prostatic secretory protein PSP94 in cynomolgus monkey (Macaca fascicularis. (1988) (23)
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1 (2004) (23)
Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells. (2002) (23)
New insights of altered lipid profile in Fragile X Syndrome (2017) (23)
The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function. (2000) (23)
Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2 (1991) (22)
Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases. (2009) (22)
Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice. (2021) (22)
A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy (2011) (22)
Direct role of furin in mammalian prosomatostatin processing. (1995) (22)
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). (2002) (22)
The high‐molecular‐mass kininogen deficient rat expresses all kininogen mRNA species, but does not export the high‐molecular‐mass kininogen synthesized (1988) (22)
Viral envelope glycoprotein processing by proprotein convertases. (2013) (22)
PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation (2013) (22)
The Cytosolic Adaptor AP‐1A Is Essential for the Trafficking and Function of Niemann‐Pick Type C Proteins (2013) (21)
Transport of ions of one kind through thin membranes (1974) (21)
Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing (2014) (21)
Proteolytic processing of chromogranin A by the prohormone convertase PC2 (2003) (21)
Purification of radiolabeled and native polypeptides by gel permeation high-performance liquid chromatography. (1982) (21)
Complete sequence of the glycosylated amino terminal segment of porcine pro-opiomelanocortin. (2009) (21)
Response of human aldosteronoma cells in culture to the N-terminal glycopeptide of pro-opiomelanocortin and gamma 3-MSH. (1983) (21)
Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. (2011) (21)
Effects of proopiomelanocortin-derived peptides, methionine-enkephalin and forskolin on the maturation of ovine fetal adrenal cells in culture. (1984) (21)
Potential Role of Proprotein Convertase SKI-1 in the Mineralization of Primary Bone (2008) (21)
N-Terminal amino acid sequence of rat tonin: homology with serine proteases. (1978) (20)
Comparative processing of bovine leukemia virus envelope glycoprotein gp72 by subtilisin/kexin‐like mammalian convertases (1997) (20)
Molecular cloning, characterization of cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1 (1999) (20)
Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts. (2009) (20)
Occurrence of an HIV‐1 gp160 endoproteolytic activity in low‐density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertases (1999) (20)
Demonstration of the vasopressin associated glycopeptide in the brain and peripheral tissues of the Brattleboro rat (1986) (20)
Propressophysin is present in neurones at multiple sites in wistar and homozygous brattleboro rat brain (1986) (20)
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance (2022) (20)
Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015) (2016) (20)
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2 (2006) (20)
Effect of alpha-1 antitrypsin Portland variant (alpha 1-PDX) on HIV-1 replication. (2000) (20)
Developmental Changes in Immunoreactive Content of Novel Pituitary Protein 7B2 in Human Pancreas and Its Identification in Pancreatic Tumors (1987) (20)
Primary structure of mouse chromogranin B deduced from cDNA sequence. (1990) (20)
Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes. (1992) (20)
Expression and Processing of the Neuroendocrine Protein Secretogranin II in Benign and Malignant Pheochromocytomas (2006) (20)
MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†. (2015) (19)
The complete sequence of sheep beta-endorphin. (1977) (19)
Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. (2011) (19)
Concomitant changes of ACTH, beta-endorphin and N-terminal portion of pro-opiomelanocortin in rats. (1982) (19)
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues. (1996) (19)
The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer (2021) (19)
Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. (2007) (19)
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury. (2020) (19)
Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule. (1995) (19)
Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species. (1990) (19)
Proprotein convertases as therapeutic targets (2008) (18)
Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin. (1995) (18)
Assignment of the gene for neuroendocrine protein 7B2 (SGNE1 locus) to mouse chromosome region 2[E3-F3] and to human chromosome region 15q11-q15. (1990) (18)
The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation (2016) (18)
Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A* (2011) (18)
Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing. (1988) (18)
Inhibition by beta-endorphin of dopamine-sensitive adenylate cyclase in rat striatum. (1977) (18)
Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/Site 1 Protease (S1P) (2013) (18)
Coordinated regulation and colocalization of αv integrin and its activating enzyme proprotein convertase PC5 in vivo (2003) (17)
Primary structure and morphine-like activity of human beta-endorphin. (1977) (17)
Purification and partial chemical characterization of human pituitary lipolytic hormone. (1976) (17)
Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis. (2020) (17)
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth (2015) (17)
Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking (2015) (17)
From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin'. (1979) (17)
The Proprotein Convertase SKI-1/S1P (2007) (16)
Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1. (1995) (16)
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1. (2011) (16)
Metabolic clearance rate and half-time disappearance rate of human N-terminal and adrenocorticotropin of pro-opiomelanocortin in the rat: a comparative study. (1983) (16)
A novel pituitary protein (7B2)-like immunoreactivity is secreted by a rat phaeochromocytoma cell line (PC12). (1986) (16)
Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin (2002) (16)
Zymogen Activation and Subcellular Activity of Subtilisin Kexin Isozyme 1/Site 1 Protease* (2014) (16)
Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin). (1986) (15)
Transport of ions of one kind through thin membranes (1972) (15)
The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit‐1/GHF‐1‐independent pathway in corticotroph AtT20 cells (1998) (15)
Complete Amino Acid Sequence of Shigella Toxin B-chain (1986) (15)
Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands. (1981) (14)
Running title : PCSK 9-enhanced LDLR degradation 1 EFFECTS OF THE PROSEGMENT AND PH ON THE ACTIVITY OF PCSK 9 : EVIDENCE FOR ADDITIONAL PROCESSING EVENTS (2010) (14)
From Proopiomelanocortin to Cancer (1993) (14)
Molecular cloning and embryonic expression of zebrafish PCSK5 co‐orthologues: Functional assessment during lateral line development (2010) (14)
Immunohistochemical localization of human pituitary glycopeptide (HPGP)-like immunoreactivity in the hypothalamus and pituitary of normal and homozygous diabetes insipidus (Brattleboro) rats. (1982) (14)
Novel approach to rapid and sensitive localization of protein disulfide bridges by high-performance liquid chromatography and electrochemical detection (1985) (13)
Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus. (1995) (13)
How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread? (2021) (13)
Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice (2020) (13)
Stable and transient expression of mouse submaxillary gland renin cDNA in AtT20 cells: Proteolytic processing and secretory pathways (1989) (13)
Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein. (2003) (13)
Morphine-like activity of sheep β-lipotropin and of its tryptic fragments (1977) (13)
Precursor polyproteins in endocrine and neuroendocrine systems. (2009) (13)
Expression of variant forms of proopiomelanocortin, the common precursor to corticotropin and beta-lipotropin in the rat pars intermedia. (1981) (12)
Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: Relationship to the maturation enzyme of prohormones (1985) (12)
Proprotein convertase 7 (PCSK7) reduces apoA‐V levels (2020) (12)
N-linked glycosylation affects the processing of mouse submaxillary gland prorenin in transfected AtT20 cells. (1991) (12)
Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases. (2006) (12)
Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond (2022) (12)
Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site. (1984) (12)
Two glycosylation sites on the N‐terminal segment of porcine pars distalis pro‐opiomelanocortin (1980) (12)
Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. (2017) (12)
Two large glycoprotein fragments related to the NH2-terminal part of the adrenocorticotropin-beta-lipotropin precursor are the end products of the maturation process in the rat pars intermedia. (1980) (12)
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection (2021) (12)
Replication of HIV-1 viruses in the presence of the Portland alpha1-antitrypsin variant (alpha1-PDX) inhibitor. (2001) (11)
An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR) in Hepatocellular Carcinoma Cells* (2016) (11)
Immunocytochemical Localization of the Prohormone Convertases PC1 and PC2 in Rat Prolactin Cells (1998) (11)
Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone. (2018) (11)
Effects of peptides of pituitary origin on the formation of C21 steroid by fetal calf adrenal cells in culture. (1977) (11)
Amino Terminal Sequence of 7B2: A Novel, Human Pituitary/Brain Polypeptide Present in Gonadotrophs and Released by LHRH (1987) (11)
Immunocytochemistry of the C-terminal peptide of propressophysin (CPP): Relationship to vasopressin, oxytocin and neurophysin (1983) (11)
Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66. (2012) (11)
Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P)* (2015) (11)
Immunoreactivity of vasopressin and a novel pituitary protein ‘7B2’ in long-evans and brattleboro rat hypothalamus and hypophysis (1985) (11)
A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice (2018) (10)
Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid β-melanocyte stimulating hormone [hβMSH(5–22)] in nonpituitary tissue (1989) (10)
ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture. (1985) (10)
Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells. (2007) (10)
Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model. (2004) (10)
Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse Chromosome 2 (1995) (10)
FRAGMENT OF SHEEP BETA-LIPOTROPIN WITH MORPHINE-LIKE ACTIVITY (1976) (10)
A NOVEL PITUITARY PROTEIN (7B2) IN THE RAT UROGENITAL TRACT (1985) (10)
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin (2019) (10)
Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin. (1978) (10)
The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analyses (1987) (10)
Angiopoietin1 Deficiency in Hepatocytes Affects the Growth of Colorectal Cancer Liver Metastases (CRCLM) (2019) (10)
Is there a link between proprotein convertase PC7 activity and human lipid homeostasis? (2014) (10)
Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics. (2018) (10)
Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli. (1988) (10)
Human NH2 terminal of pro-opiomelanocortin as a potential marker for pulmonary carcinoma. (1983) (10)
Hypolipidaemia among patients with PMM2-CDG is associated with low circulating PCSK9 levels: a case report followed by observational and experimental studies (2019) (9)
The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. (1991) (9)
Thrombin activation of protein C requires prior processing by a liver proprotein convertase (2017) (9)
9 Cellular limited proteolysis of precursor proteins and peptides (2001) (9)
Pcsk5 is required in the early cranio-cardiac mesoderm for heart development (2017) (9)
Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases. (2009) (9)
Alternative Proteolytic Processing of Mouse Mammary Tumor Virus Superantigens (2000) (9)
Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay. (1989) (9)
Immunohistochemical localization of γ-melanocyte-stimulating hormone in the rat pituitary gland (1981) (9)
Statins can exert dual, concentration dependent effects on HCV entry in vitro. (2016) (9)
The Elusive Inhibitory Function of the Acidic N-Terminal Segment of the Prodomain of PCSK9: The Plot Thickens. (2019) (9)
Evaluation of Anti-Proprotein Convertase Activity of Diterpene Andrographolid Derived Products (2006) (9)
Furin cleaves SARS-CoV-2 spike-glycoprotein at S1/S2 and S2'for viral fusion/entry: indirect role for TMPRSS2 (2020) (9)
Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and beta-lipotropin in mouse pituitary cells. (1981) (8)
The H5N1 Influenza Variant Fujian-Like Hemagglutinin Selected Following Vaccination Exhibits a Compromised Furin Cleavage (2008) (8)
The metabolism of -amyloid converting enzyme and -amyloid precursor protein processing (2004) (8)
ANF mRNA IS DETECTED BY THE POLYHERASE CHAIN REACTION TECHNIQUE IN THE CHORIOIDRA AND CILIARY BODIES BUT NOT IN THE RETINA OF THE RAT EYE (1991) (8)
Immunohistochemical Localization of the Pro-Peptide Processing Enzymes PC1/PC3 and PC2 in the Human Anal Canal (1997) (8)
[1] Molecular strategies for identifying processing enzymes (1995) (8)
Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells. (2016) (8)
Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand” (1989) (8)
Elevation of plasma 7B2 (a novel pituitary protein) in cord blood at obstetrical delivery and the possible correlation with GH. (1987) (8)
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin (2021) (8)
Expression and sorting of rat plasma kallikrein in POMC-producing AtT-20 cells. (1991) (7)
Biosynthesis of hormonal and neural peptides. (1984) (7)
A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease. (2017) (7)
Application of high-performance liquid chromatography to characterize radiolabeled peptides for radioimmunoassay, biosynthesis, and microsequence studies of polypeptide hormones. (1983) (7)
Peptides related to the N-terminus of pro-opiomelanocortin in the human adrenal medulla. (1989) (7)
Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells (2021) (7)
PACE4 (PCSK6): another proprotein convertase link to iron homeostasis? (2015) (7)
Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain (1988) (7)
Insights into a PCSK9 structural groove: a harbinger of new drugs to reduce LDL-cholesterol (2017) (7)
PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs (2021) (6)
Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. (1993) (6)
Subcellular fractionation of pituitary neurointermediate lobes: revelation of various basic proteases. (1984) (6)
Processing of Peptide Hormone and Neuropeptide Precursors1 (1984) (6)
Enzymatic maturation of pro-opiomelanocortin by anterior pituitary granules. Methodological approach leading to definite characterization of cleavage sites by means of high-performance liquid chromatography and microsequencing. (1983) (6)
Biosynthesis of a ubiquitin-related peptide in rat brain and in human and mouse pituitary tumors. (1978) (6)
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing. (2004) (6)
Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis. (2014) (6)
ISOLATION AND NH 2 -TERMINAL SEQUENCE OF A HIGHLY CONSERVED PITUITARY AND HYPOTHALAMIC PROTEIN BELONGING TO A NEW SUPERFAMILY (1983) (6)
Inhibition of binding of ovine placental lactogen to growth hormone and prolactin receptors by monoclonal antibodies. (1986) (6)
Abstract 830: The Proprotein Convertase PCSK9 Induces The Degradation Of LDLR And Its Closest Family Members VLDLR And ApoER2 (2007) (6)
Synergistical effects of ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on the release of pro-opiomelanocortin (POMC) related peptides by pituitary adenoma of a patient with Nelson's syndrome in vitro. (1984) (6)
Inhibition of release of a novel pituitary polypeptide, 7B2, follicle-stimulating hormone, and luteinizing hormone from rat anterior pituitary cells in vitro by human beta-inhibin. (1986) (5)
Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition: A Genome-Wide Association Study and Mendelian Randomization Study in the HUNT, Norway (2019) (5)
Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia (2021) (5)
Distribution of a novel pituitary protein (7B2) in mammalian gastrointestinal tract and pancreas (1988) (5)
Affinity purification of proteinases by a combination of immobilized peptidyl aldehyde and semicarbazone. (1992) (5)
Chemical characterization of adrenocorticotropin and a novel peptide biosynthesized from a pituitary adenoma of a patient with Cushing's disease. (1980) (5)
Spin labels as probes for tetraphenylboron ion interaction with liposomes. (1976) (5)
Posttranslational Processing of Secretory Proteins (2016) (5)
The primary structure of human β‐lipotropin (1982) (5)
The messenger RNA for pituitary protein 7B2 is widely expressed in mouse CNS and castration reduces its pituitary level (1991) (5)
ANF mRNA is detected by the polymerase chain reaction technique in the chorioidea and bodies but not in the retina of the rat eye. (1991) (5)
Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis. Further characterization. (2009) (5)
From proopiomelanocortin to cancer. Possible role of convertases in neoplasia. (1993) (5)
Cell-free synthesis of porcine proopiomelanocortin: two distinct primary translation products. (1983) (5)
IN VITRO BIOSYNTHESIS AND CHEMICAL CHARACTERIZATION OF ACTH AND ACTH FRAGMENTS BY THE RAT PARS INTERMEDIA (1980) (5)
Can iPCSK9-induced hypocholesterolemia starve cancer cells? (2017) (5)
Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression (2020) (5)
Primary structure of the ovine pituitary follitropin beta-subunit. (1981) (5)
Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice. (2009) (5)
Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation. (2016) (5)
Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene. (2002) (4)
In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography. (2013) (4)
Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2 (2020) (4)
LDL cholesterol PCSK 9 A Key Modulator of Cardiovascular Health (2014) (4)
PC 5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC 5-transfected PC 12 Cells (1998) (4)
Molecular evolution of the proopiomelanocortin system in Barn owl species (2020) (4)
[Endorphins: structure, roles and biogenesis]. (1981) (4)
Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity (2022) (4)
Peptide mapping of 125I-labelled membrane protein of influenza viruses by reverse-phase high-performance liquid chromatography. (1982) (4)
Opposite Roles of Furin and PC 5 A in N-Cadherin Processing 1 (2012) (4)
PCSK9 is not secreted from mature differentiated intestinal cells (2021) (4)
Biosynthesis of β-Endorphin in the Rat Pars Intermedia (1980) (4)
Functional analysis of natural PCSK9 mutants in modern and archaic humans (2020) (4)
The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity (2020) (4)
Evaluating The Roles Of PCSK9 And Specific Receptors In Lipoprotein(A) Catabolism (2016) (4)
The role of the NH2-terminal portion of pro-opiomelanocortin as a biomarker for human lung cancer. (1987) (4)
Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication. (2002) (4)
Proprotein Convertases SKI-1/S1P and PCSK9 (2013) (4)
On the circulating form of atrial natriuretic factor. (1985) (4)
Site-1 Protease (2013) (3)
Inhibition of HIV-2ROD replication in a lymphoblastoid cell line by the α1-antitrypsin Portland variant (α1-PDX) and the decRVKRcmk peptide: comparison with HIV-1LAI (2001) (3)
Structure and maturation process of pro-opiomelanocortin: a model for other neuropeptides. (1980) (3)
Biosynthesis of f-endorphin from f 3-lipotropin and a larger molecular weight precursor in rat pars intermedia ( endogenous opiates / prohormones / corticotropin / radiolabeled peptide sequencing / pituitary gland ) (3)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in Alzheimer mice (2010) (3)
Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides. (1980) (3)
Role of convertases in the processing of neuropeptides and neurotrophins (1996) (3)
Cathepsin-B fusion proteins misroute secretory protein partners such as the proprotein convertase PC2-7B2 complex toward the lysosomal degradation pathways. (2000) (3)
Genetic Mapping of the Gene for SKI-1/S1P Protease (locus Symbol Mbtps 1) to Mouse Chromosome 8 (2002) (3)
Co-expression of PC2 and proenkephalin in human tumoral adrenal medullary tissues. (1994) (3)
Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. (2017) (3)
A rapid high-performance liquid chromatography purification method of iodinated polypeptide hormones. (1980) (3)
Invitro biosynthesis off3-endorphin inpituitary glands (1977) (3)
Detection from rat pituitary of beta-lipotropin and materials containing opiatelike activity by combined enzymatic radioreceptor assay. (1981) (3)
Differential expression and pro cessing of secretogranin II in relation to the status of pheochromocytoma : implications for the production of the tumoral marker EM 66 (2012) (3)
The Jeremiah Metzger Lecture. From POMC to functional diversity of neural peptides: the key importance of convertases. (1991) (3)
cDNA structure and in situ localization of the Aplysia californica pro‐hormone convertase PC2 (1994) (3)
Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells (1982) (3)
PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol. (2022) (3)
[Prader-Willi-Labhart syndrome: relations with the hypothalamus and chromosome 15]. (1990) (3)
High levels of serum cholesterol positively correlate with the risk of the development of vessel co-opting tumours in colorectal cancer liver metastases (2022) (3)
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23 (2021) (3)
Emerging viruses: risk of pandemic (2008) (3)
Proprotein Convertase 7 (2013) (3)
Primary hyperaldosteronism: a pituitary--adrenal dysfunction related to a new pituitary glycopeptide? (1982) (3)
Effect of alpha-1 antitrypsin Portland variant ( α 1-PDX ) on HIV-1 replication (2)
Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers (2022) (2)
Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. (2000) (2)
Immunological characterization of beta-lipotropin fragments (endorphin, beta-MSH, and N-fragment) from fish pituitaries. (1978) (2)
The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation (2018) (2)
[Endorphins 1989: neuroendocrine aspects]. (1989) (2)
Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid. (1987) (2)
A novel human pituitary peptide containing the gamma-MSH sequence. (1980) (2)
Erratum: Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions (Journal of Biological Chemistry (2018) 293 (7408-7422) DOI: 10.1074/jbc.M117.817981) (2019) (2)
Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney. (1984) (2)
Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA. (1987) (2)
Pro-Protein and Pro-Hormone Convertases (1992) (2)
Distribution pattern in the human pituitary and hypothalamus of a new neuropeptide: The C-terminal glycoprotein-fragment of human pro-pressophysin (CPP) (2004) (2)
Biochemical aspects of a new hormone: rat atrial natriuretic factor (rANF). (1985) (2)
PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity (2022) (2)
Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a) (2022) (2)
5‐Thiomannosides Block the Biosynthesis of Dolichol‐Linked Oligosaccharides and Mimic Class I Congenital Disorders of Glycosylation (2012) (2)
Beta-lipotropin precursor of beta-MSH and beta-endorphin. (1979) (2)
Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis. (2017) (1)
Functional Analysis of Novel PCSK9 Mutants from Sapiens (R96L, R105W and P174S) and Denisovan (H449L) (2018) (1)
Morphine-like activity of sheep beta-lipotropin and of its tryptic fragments. (1977) (1)
FURIN IS THE MAJOR PROCESSING ENZYME OF THE CARDIAC-SPECIFIC GROWTH FACTOR BMP10 (2011) (1)
The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR (2007) (1)
beta 2-Inhibin contains the active core of human seminal plasma beta-inhibin: synthesis and bioactivity. (1985) (1)
Immunohistochemical localization of gamma-melanocyte-stimulating hormone in the rat pituitary gland. (1981) (1)
Complete aminoacidsequence ofahumanpituitary glycopeptide: Animportant maturation product ofpro-opiomelanocortin (1981) (1)
Urinary levels of immunoreactive NH2-terminal of pro-opiomelanocortin in patients with malignant pulmonary disease. (1989) (1)
An aldosterone stimulating agent: a novel human pituitary hormone from pro-opiomelanocortin. (1981) (1)
[Biosynthesis of beta-endorphin]. (1978) (1)
PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity (2023) (1)
Synthetic proregion-related peptides of proprotein convertases, PC1 and furin, represent potent inhibitors of each protease (2002) (1)
Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products. (1987) (1)
A novel cell‐based sensor detecting the activity of individual basic proprotein convertases (2019) (1)
Synthesis of the segment (11-23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328-343) to high-molecular-mass kininogen. (1993) (1)
Design of octadecapeptide loop structures by modeling the active-site region of barley serine proteinase inhibitor-2 (1994) (1)
Gamma-3-MSH and beta-endorphin in monkey pituitary. (1986) (1)
Gene expression of peptides: the pro-opiomelanocortin model. (1982) (1)
The proprotein convertases in health and disease (2012) (1)
[Decrease in the immunoreactivity of protein 7B2 in vasopressinergic cells in the supraoptic nucleus and in fibers of the neurohypophysis, in Brattleboro rats]. (1988) (1)
BIOSYNTHESIS AND MATURATION OF PRO-OPIOMELANOCORTIN (1981) (1)
Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). (2001) (1)
Thrombin activation of protein C requires prior processing by a liver proprotein convertase. (2017) (1)
3 – Biosynthesis of β-Endorphin from Proopiomelanocortin (1981) (1)
Corrigendum: PCSK9 is not secreted from mature differentiated intestinal cells. (2022) (1)
[Beta-endorphin induced akinesia in rats: a pharmacological study (author's transl)]. (1979) (1)
Post-Transcriptional Effects of miRNAs on PCSK7 Expression and Function: miR-125a-5p, miR-143-3p, and miR-409-3p as Negative Regulators (2022) (1)
Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels (2022) (1)
Reply: To PMID 23390091. (2013) (1)
Transport of ions of one kind through thin membranes (1974) (1)
PRO-OPIOMELANOCORTIN: A NEW CONCEPT ISSUED FROM ACTH AND LPH BIOSYNTHETIC STUDIES (1980) (1)
Proprotein Convertase PCSK9 (2013) (1)
REDUCTION IN LIPOPROTEIN (A) WITH EVOLOCUMAB: ELUCIDATION OF THE ROLE OF THE LDL RECEPTOR FROM CLINICAL TRIALS AND IN-VITRO MODELS (2016) (1)
[Biosynthesis of polypeptide hormones]. (1980) (1)
A Highly Selective Cell Permeable Peptide Inhibitor of Proprotein Convertase 1: Design, Synthesis and Biological Evaluation in Cellular PC1-Mediated Proteolysis (2001) (1)
A novel cell-based sensor detecting the activity of individual basic proprotein convertases (2018) (1)
Abstract 20583: Sortilin Promotes Secretion of Apolipoprotein(a) by Hepatic Cells (2016) (1)
Purification of Radiolabeled and Native Polypeptides by Gel Permeation High-Performance Liquid Chromatography1 (1983) (1)
The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis. (1987) (1)
The family of prohormone and proprotein convertases (2009) (1)
Proprotein Convertases PC4, PACE4, and PC7 (2013) (1)
PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis (2022) (1)
Pcsk5in mice with mutation in the proprotein convertase VACTERL/caudal regression/Currarino syndrome-like (2008) (0)
Su2009 PCSK9 Plays a Significant Role in Cholesterol Homeostasis and Lipid Transport in Intestinal Epithelial Cells (2012) (0)
The primary structure of human beta-lipotropin. Further peptide sequencing resolves the controversy and suggests the existence of only one human beta-lipotropin. (1982) (0)
Proprotein Convertase Subtilisin / Kexin type 9 a ff ects insulin but not lipid metabolism in cystic fi brosis (2017) (0)
Proprotein Convertase 1/3 (2013) (0)
Errata and Corrigenda (2001) (0)
5 malformations in mice with mutation in the proprotein convertase VACTERL / caudal regression / Currarino syndrome-like data (2008) (0)
CONSORT flow diagram: Flow of participants through the trial. (2013) (0)
Structure Analysis and Maturation of Pro-Opiomelanocortin in Rat Pars intermedia (1980) (0)
Light and electron microscopic localization of the N-terminal fragment of human pro-opiomelanocortin in the human pituitary gland and in neoplasms (2004) (0)
P3-337: S-palmitoylation targets BACE-1 to lipid rafts (2008) (0)
Apoe P.Leu167Del Mutation in Familial Hypercholesterolemia (2013) (0)
Isolation and Purification of Escherichia coli Heat-Stable Enterotoxin of Porcine Origin 1 (1983) (0)
Proprotein Convertase Furin and Proprotein Convertase PC5/6 (2013) (0)
Abstract 3860: Furin is required for processing KISS1 to kisspeptins. (2013) (0)
Characterization of peptides derived from pro-opiomelanocortin in the biological fluids of a patient with Nelson's syndrome. (1985) (0)
Microsequence of Polypeptide Hormones: Its Usefulness to Monitor the Isolation of Novel Molecules (1985) (0)
The Possible Role of Plasma Kallikrein in Pro-Hormone and Pro-Enzyme Processing (1988) (0)
STATINS AND EZETIMIBE UPREGULATE PLASMA PCSK9 (2008) (0)
alpha-secretase cleavage of APP in the furin-deficient LoVo cell line: Involvement of the prohormone convertase PC7 and the disintegrin ADAM10 (2002) (0)
O2-03-01: Exploring β-secretase activity in lipid raft microdomains (2008) (0)
BIOSYNTHESIS OF BETA-ENDORPHIN AND ALPHA-MSH IN THE PARS INTERMEDIA OF RAT PITUITARIES (1980) (0)
[Physiological roles of endorphins in 1987]. (1988) (0)
Insulin Infusion Acutely Downregulates Circulating PCSK9 in Human (2014) (0)
Mutations em human PCSK9 gene associated with hypercholesterolemia. (2004) (0)
Functional Aspects of Multitransmitter Neurons (1987) (0)
The Convertases Furin and PC1 Can Both Cleave the Human Immunodeficiency Virus (HW)-1 Envelope Glycoprotein a160 into (1994) (0)
Discovery of the Proprotein Convertases and their Inhibitors (2006) (0)
[In vitro biosynthesis of beta-lipotropin in brain tissue]. (1979) (0)
Abstract 19748: Mature Enterocytes Lose Their Ability to Secrete Pcsk9 (2016) (0)
Paired basic amino acid convertases of pro-hormones and pro-proteins (1992) (0)
Abstract 5526: Genetic Variation at PCSK5 Influences HDL-C Levels (2008) (0)
Peptide Separation Using Guanidine-Hcl During Reverse-Phase High Performance Liquid Chromatography (1985) (0)
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. (2019) (0)
Development of Peptide Inhibitors Disrupting PCSK9-LDLR Protein-Protein Interactions (2013) (0)
Abstract 135: Phosphorylation and furin-mediated processing are critical posttranslational modifications of the KISS1 metastasis suppressor (2014) (0)
Abstract 437: Lipoprotein(a) Internalization in HepG2 Cells is Regulated by Proprotein Convertase Subtilisin Kexin Type 9 Through the Low-Density Lipoprotein Receptor (2014) (0)
Prosomatostatin Processing by PCl , PC 2 , and Furin 6043 (2001) (0)
Tumorigenicity Platelet-derived Growth Factor-A-induced Functions and Convertase Family Is Functionally Correlated to by Members of the Proprotein 86 Factor-A at RRKR The Proteolytic Processing of Pro-Platelet-derived Growth (2003) (0)
IRCM‐Serine Protease # 1 from Pituitary and Heart A Common Prohormone Maturation Enzyme (1987) (0)
Neuronal and Endocrine Peptides (1988) (0)
[The pituitary and morphinomimetic peptides]. (1977) (0)
Amino Acid Sequence of the Alpha and Beta Subunits of Ovine Pituitary Follitropin (FSH) (1982) (0)
SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2 (2023) (0)
Molecular Lipids Provide More Information on PCSK9 Deficiency Than LDL-Cholesterol (2012) (0)
In vitro biosynthesis of f 3-endorphin in pituitary glands ( ft-lipotropin / endogenous opiate / peptide with morphine-like activity / hormone ) (0)
Abstract 261: Liver-specific Pcsk9 Knockout And Transgenic Mice (2007) (0)
EFFECT OF MORPHINE OR ALCOHOL TREATMENT ON THE BIOSYNTHESIS OF β-ENDORPHIN BY THE NEUROINTERMEDIATE LOBE (1981) (0)
Testis-Specific Proprotein Convertase 4: Gene Structure, Optional Exons, and mRNA Isoforms (1994) (0)
Proprotein Convertase 4 (2013) (0)
[Endorphins: structure, role and biogenesis]. (1983) (0)
Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings. (1989) (0)
An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and LDL Receptor in Hepatocellular Carcinoma Cells (2016) (0)
Role and regulation of the proprotein convertase subtilisin/kexin type 9 (PCSK9) in the small intestine (2008) (0)
Proteolytic processing of the x-subunit of rat endopeptidase-24.18 by furin (2005) (0)
Erratum for Essalmani et al., “Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity” (2022) (0)
Impact of the Mediterranean diet and weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome (2011) (0)
Effect of the p.Arg357His mutation of PCSK9 on basal and postprandial lipoprotein metabolism. (2017) (0)
Atrial natriuretic factor: isolation, identification, biological and pharmacological actions. (1985) (0)
Mammalian pro-hormone convertase (1997) (0)
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR that is shed by Furin (2021) (0)
3FS07-5 NARC-1: A potential new target for drug therapy of hypercholesterolemia (2003) (0)
Crosstalk between Bone and Muscle: Deletion of Mbtps1 in Bone Leads to Age‐Dependent Increase in Muscle Size and Contractile Function (2015) (0)
The Atrial Natriuretic Factor Purification, Isolation of the Peptide and of Prepro ANF, and Physiological Studies (1986) (0)
Osteopontin as a novel substrate for proprotein convertase 5/6 (PCSK5) in bone (2014) (0)
Complete amino acid sequence of a human pituitary glycopeptide : An important maturation product of pro-opiomelanocortin ( pituitary hormones / corticotropin / lipotropin / sequence microdeterminations / aldosterone-stimulating substance ) (0)
GAMMA+lRLANOTROPIN RESPONSE TO OVINE CORTICOTROPIN RELEASING FACTOR IN NORHAL RDtUNS (1987) (0)
MS91 PCSK9: FROM GENE AND VARIANTS TO PROTEIN AND PLASMA LEVELS (2010) (0)
Chemical characterization of rat alpha MSH/beta-endorphin precursor from pars intermedia. (1980) (0)
Abstract 15443: Unexpected Role of PCSK9 in Human Pluripotent Stem Cells and Their Differentiation (2016) (0)
Neuroendocrine Peptide Processing (2009) (0)
Abstract 5: A Novel APOE p.Leu166del Mutation in Autosomal Dominant Familial Hypercholesterolemia (2013) (0)
MATURATION OF THE COMMON PRECURSOR FOR BETA-ENDORPHIN AND ALPHA-MSH IN THE RAT PARS INTERMEDIA (1980) (0)
Adenoviral overexpression of AnxA2 in mouse liver significantly increases LDLR levels. (2012) (0)
Implication of prohormone convertates in the precursor processing of neuropeptides, hormones and growth factors: experimental and developmental models of the central and peripheral nervous system (1995) (0)
Diversity and Gene Expression (1988) (0)
Peptides and polypeptides from the submaxillary gland of the rat, monoclonal and polyclonal antibodies corresponding, hybridomas and corresponding applications of such products in the diagnosis, detection or for therapeutic purposes (1988) (0)
The proprotein convertase SKI-1/S1P is a critical host factor for Nairobi sheep disease virus infectivity. (2023) (0)
Proprotein convertases are responsible for proteolysis and inactivation of endothelial lipase. VOLUME 280 (2005) PAGES 36551-36559 (2005) (0)
The proprotein convertase chaperone protein 7B2 is a new immunohistochemistry marker for primary and metastatic neuroendocrine tumors of the pancreas and GI tract (2005) (0)
Efficacy Readout for PCSK9 Inhibition (2011) (0)
Detection of prohormone convertases in developing and adult mouse submandibular glands (1994) (0)
PROCESSING OF PRO-OPIOMELANOCORTIN IN RAT, PORCINE AND HUMAN PITUITARIES (1981) (0)
GLYCOPROTEIN MATURATION OF THE E2 SURFACE Inhibitors: IMPAIRMENT OF THE in Cultured Human Muscle Cells by Furin Inhibition of Chikungunya Virus Infection Modification, and Degradation: Protein Synthesis, Post-Translational (2013) (0)
PC7 contributes to the processing of the Alzheimer's βamyloid precursor protein in human cells (2000) (0)
Proprotein Convertase 5 (2013) (0)
New perspectives in neuropeptides. Biosynthesis from large precursors. The pro-opio-melanocortin model in the pars intermedia. (1980) (0)
Abstract 5567: The Ldlr -/- Mouse as a Novel Model of Aortic Calcification: Application of Micro-Computerized Tomography (2009) (0)
LDLR Activity and Subcellular Distribution is Sensitive to Estrogen in Mice Lacking PCSK9 (2018) (0)
Proinsulin-like peptide in porcine anterior pituitary: Purification and NH2-terminal sequence (1983) (0)
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin (2019) (0)
Abstract 432: MEK/ERK Inhibition Corrects the Defect in VLDL Assembly and Secretion in HepG2 Cells via Activation of Cell Death--Inducing DFFA-Like Effector B (Cide B), ApoCIII and Lipin-1 (2012) (0)
43 NEW GAIN OF FUNCTIONS MUTATIONS IN PCSK9 AND THEIR IMPACT IN FAMILIAL HYPERCHOLESTEROLEMIA (2011) (0)
Back cover: Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells (2016) (0)
Hypocholesterolaemia in chronic Hepatitis C virus (HCV) infection – Reduced production or increased LDL clearance? (2010) (0)
The spîke (S)-protein of SARS-CoV-2 binds ACE2 and requires proteolytic “priming” at PRRAR685↓ (2021) (0)
Isolation, Sequence and Cytochemical Localization of a Conserved Novel Pituitary-Hypothalamic Protein (1984) (0)
The Proprotein Convertases: Cell Surface and Extracellular Matrix Remodeling (2015) (0)
Inactivation of furin by its naturally occurring inhibitor pro-furin abolish breast cancer cells malignant phenotypes and tumorigenecity in mice. (2006) (0)
Subcellular Sorting and Processing of Prorenin (2018) (0)
pheochromocytoma : implications for the production of the tumoral marker EM66 2 (2012) (0)
Generation And Phenotypical Characterization Of An Intestinal Pcsk9 Deficient Mice. (2019) (0)
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance (2022) (0)
Abstract 366: Inhibition of Interleukin-1ß by a Monoclonal Antibody Therapy Reduces Vascular Calcification in Ldlr-/- Mice (2014) (0)
PCSK9 REDUCES HEPATIC LIPID CONTENT AND CONFERS PROTECTION AGAINST ER STRESS AND ROS IN HEPG2 CELLS (2018) (0)
Multi-pathway cholesterol depletion on top of FOLFIRINOX in newly-diagnosed metastatic pancreatic adenocarcinoma (2021) (0)
Mutation Screening of PCSK9 Exons in Iranian Arab Patients Suffering from Familial Hypercholesterolemia (2023) (0)
Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling (2023) (0)
The propeptide Asnt ' Tyr 126 is the storage form of rat atrial natriuretic factor (2005) (0)
Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9. (2023) (0)
The Multifaceted Biology of PCSK9 (2021) (0)
New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia (2018) (0)
Pcsk5 is required in the early cranio-cardiac mesoderm for heart development (2017) (0)
Abstract 1741: Inhibition of pcsk9 impairs the development of vessel co-option and potentiates anti-angiogenic therapy in colorectal cancer liver metastases (2023) (0)
Inhibition of sterol regulatory element-binding protein cleavage by the prodomain of human SKI-1 protease (2000) (0)
Complete PCSK9 C-ter domain in complex with VHH P.140 (2019) (0)
Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor (2018) (0)
Abstract 14273: Atorvastatin Increases Intestinal Expression of Niemann-Pick C1-Like-1 in Hyperlipidemic Men (2010) (0)
Pharmacological Inhibition And Hepatic-Deficiency Of Pcsk9 Reduce Post-Prandial Lipemia In Mice (2019) (0)
488 EFFICACY BIOMARKER FOR PCSK9 INHIBITORS (2011) (0)
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors (2022) (0)
Reply: (2013) (0)
Characterization of beta-endorphin immunoreactive peptides in rat pituitary and brain by coupled gel and reversed-phase high-performance liquid chromatography. (1983) (0)
Abstract 1181: Human PCSK9 Mutations And Post-translational Modifications Provide A Novel View On Its Regulation Of Ldl-cholesterol (2007) (0)

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