Namandjé Bumpus
#57,989
Most Influential Person Now
American pharmacologist
Namandjé Bumpus's AcademicInfluence.com Rankings
Namandjé Bumpusmedical Degrees
Medical
#763
World Rank
#1004
Historical Rank
#272
USA Rank
Pharmacology
#464
World Rank
#521
Historical Rank
#47
USA Rank
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Medical
Namandjé Bumpus's Degrees
- PhD Pharmacology University of California, San Francisco
- Bachelors Chemistry Stanford University
Why Is Namandjé Bumpus Influential?
(Suggest an Edit or Addition)According to Wikipedia, Namandjé N. Bumpus is an American pharmacologist and the Chief Scientist of the Food and Drug Administration. She was previously director of the department of pharmacology and molecular sciences at Johns Hopkins University School of Medicine, where she holds the E.K. Marshall and Thomas H. Maren professorship in pharmacology. Bumpus is known for her research on the metabolism of antiviral drugs used to treat HIV-1 and how genetic variations in drug-processing enzymes may impact these drugs' efficacy. Bumpus received a Presidential Early Career Award for Scientists and Engineers in 2016.
Namandjé Bumpus's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. (2012) (2748)
- HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention (2014) (284)
- MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments (2013) (194)
- Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. (2015) (178)
- A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy. (2014) (170)
- Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications. (2008) (145)
- Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066). (2016) (144)
- RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate. (2012) (132)
- Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz (2012) (124)
- Metabolism of Efavirenz and 8-Hydroxyefavirenz by P450 2B6 Leads to Inactivation by Two Distinct Mechanisms (2006) (74)
- Undisclosed antiretroviral drug use in a multinational clinical trial (HIV Prevention Trials Network 052). (2013) (73)
- Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism (2012) (50)
- Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. (2011) (50)
- Transgender women on oral HIV pre‐exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men (2019) (49)
- Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities (2019) (47)
- Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value (2017) (45)
- Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice (2014) (44)
- Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc (2012) (38)
- THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION (2005) (38)
- Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer. (2016) (35)
- CYP3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers (2014) (35)
- Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid (2013) (33)
- Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner (2015) (33)
- Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization (2014) (30)
- Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study (2014) (29)
- Dissimilarities in the metabolism of antiretroviral drugs used in HIV pre-exposure prophylaxis in colon and vagina tissues. (2013) (28)
- Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms (2004) (28)
- A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate (2014) (28)
- 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-Stimulated Hepatic Expression of Cyp4a10, Cyp4a14, Cyp4a31, and Other Peroxisome Proliferator-Activated Receptor α-Responsive Mouse Genes Is AICAR 5′-Monophosphate-Dependent and AMP-Activated Protein Kinase-Independent (2011) (27)
- Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison (2013) (27)
- A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression (2014) (27)
- Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction. (2010) (26)
- A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites (2020) (26)
- Antiretroviral drug concentrations in brain tissue of adult decedents. (2020) (22)
- Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV‐1 Transcription in a Phase IIb Trial (2018) (21)
- Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067 (2018) (15)
- Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism (2021) (14)
- Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity (2008) (14)
- Too many senior white academics still resist recognizing racism (2020) (13)
- In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19 (2020) (12)
- Structure–Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz (2014) (12)
- MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema (2018) (11)
- Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole (2016) (11)
- Genetic Variation of the Kinases That Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells. (2018) (10)
- Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease (2022) (7)
- Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8‐Hydroxyefavirenz Exhibit Divergence in Activation (2018) (7)
- Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following In Vivo Dosing Correlate with Their Safety Profiles in Humans (2020) (5)
- Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death (2020) (5)
- Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites (2021) (5)
- Biotransformation and bioactivation reactions – 2018 literature highlights (2019) (5)
- Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry (2022) (4)
- In silico Approach Toward the Identification of Unique Peptides from Viral Protein Infection: Application to COVID-19 (2020) (4)
- Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1 (2018) (4)
- Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir. (2019) (4)
- Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells (2022) (3)
- Pharmacogenomics of Antiretroviral Drug Metabolism and Transport. (2020) (3)
- Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites. (2021) (3)
- Short-term Disulfiram to Reverse Latent HIV Infection: A Phase 2 Dose Escalation Study (2016) (3)
- Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid‐Based Electrochemical Sensors (2022) (3)
- THE NATURALLY OCCURRING CYTOCHROME P 450 ( P 450 ) 2 B 6 K 262 R MUTANT OF P 450 2 B 6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION (2005) (3)
- Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro (2021) (3)
- A Mechanistic In Vivo/Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention (2021) (2)
- EstG is a novel esterase required for cell envelope integrity in Caulobacter (2022) (2)
- Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076) (2021) (2)
- Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal (2021) (2)
- Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study (2021) (2)
- Response to “Clinical Relevance of CYP3A5 Genotype on Maraviroc Exposures” (2015) (2)
- Moving toward inclusion (2015) (2)
- Revealing Sex and Alzheimer’s Disease‐related Changes in the Spatial Localization of Brain Lipids in Mice using Mass Spectrometry Imaging (2022) (1)
- For better drugs, diversify clinical trials (2021) (1)
- Tenofovir Plasma Concentration from Preexposure Prophylaxis at the Time of Potential HIV Exposure: a Population Pharmacokinetic Modeling and Simulation Study Involving Serodiscordant Couples in East Africa (2019) (1)
- Single‐Cell Proteomic Profiling of Hepatocytes Reveals Heterogeneous Responses to Hepatotoxic Drugs Nevirapine, Efavirenz, and Acetaminophen (2022) (1)
- PGRMC1 Stabilizes Cytochromes P450 And Is Required for Activity In Vivo (2020) (1)
- Mucosal Expression of the Cytochromes P450 (CYP) and Nucleotide Kinases Involved in the Biotransformation of Drugs Used in Human Immunodeficiency Virus (HIV) Pre‐exposure Prophylaxis (PrEP) (2013) (1)
- The Effects of a Naturally Occurring Genetic Polymorphism on the Catalytic Properties of Human Cytochrome P450 2B6. (2008) (1)
- Metabolism of Long-Acting Rilpivirine Following Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076). (2020) (1)
- Regulation of cyp4a31 by AMP‐activated protein kinase and peroxisome proliferator activated receptor alpha (2010) (0)
- Nucleoside Triphosphate Diphosphohydrolases Dephosphorylate the Pharmacologically Active Metabolite of Tenofovir (2020) (0)
- Activation of X‐Box Binding Protein 1 Splicing Contributes to Efavirenz‐mediated Hepatocyte Death (2018) (0)
- Determination of the P450‐ and UGT‐dependent Biotransformation of the Anti‐HIV Drugs Cabotegravir and Dolutegravir (2017) (0)
- Pharmacogenetic Analysis of Nucleotide Kinases that Metabolize the Antiviral Drug Tenofovir (2015) (0)
- Correction to “Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study” (2021) (0)
- Naturally Occurring Mutations in Creatine Kinase Brain‐Type Exhibit Decreased Tenofovir Activation In Vitro (2021) (0)
- Age Differences in the Stimulation of Murine Hepatic XBP‐1 Splicing in Response to the Anti‐HIV Drug Efavirenz (2018) (0)
- DMD060194 1796..1802 (2014) (0)
- The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module (2022) (0)
- P450 3A5 is primarily responsible for the formation of the most abundant oxidative metabolite of maraviroc (2012) (0)
- Development of MALDI MSI methods for detection, identification and localization of tenofovir and tenofovir diphosphate (2018) (0)
- Impact of Genetics and Age on Muscle‐type Creatine Kinase (2022) (0)
- Structure‐Activity Analysis of Efavirenz‐Mediated Modulation of Pregnane X Receptor Target Genes (2015) (0)
- Tenofovir‐Diphosphate Formation by Creatine Kinase Brain‐Type is Diminished by Naturally Occurring Mutations In Vitro (2022) (0)
- Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain (2023) (0)
- Age as a factor in the activation of hepatic XBOX-binding protein 1 by the anti-HIV drug Efavirenz (2018) (0)
- Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems (2023) (0)
- Naturally‐Occurring Mutations to Muscle‐Type Creatine Kinase Differentially Impact Canonical and Pharmacological Activities in Vitro (2021) (0)
- Naturally Occurring Mutations in Muscle‐Type Creatine Kinase Impact Tenofovir Monophosphate Phosphorylation (2019) (0)
- Impact of Adenylate Kinases and Naturally Occurring Adenylate Kinase 2 Variants on the Phosphorylation of the Anti‐HIV Drug Tenofovir (2018) (0)
- The impact of AK2 genetic variants on the phosphorylation of the anti-HIV drug, tenofovir (2018) (0)
- Compartmental distribution and antiviral effect of efavirenz metabolites (2013) (0)
- Efavirenz Treatment Activates XBP1 Splicing in Primary Hepatocytes: a Comparison Across Species and an Investigation into the Role of PXR (2017) (0)
- Mass Spectrometry‐Based Proteomic Profiling of Efavirenz‐, Nevirapine‐, and Acetaminophen‐Induced Toxicity in Primary Human Hepatocytes (2021) (0)
- Ecological Factors affecting the Density of Leaf Apple Galls on Arroyo Willow in a Restored Urban Stream. (2001) (0)
- The Naturally Occurring P450 2B6 K262R Mutant of P450 2B6 Exhibits Alterations in Substrate Metabolism and Inactivation (2005) (0)
- Efavirenz Biotransformation in Brain Microsomes and Neural Cells (2022) (0)
- Glucuronidation of Efavirenz and its Cytochrome P450‐dependent Metabolites in Brain Microsomes and Neurons (2021) (0)
- CYP3A5 genotype impacts maraviroc pharmacokinetics in healthy volunteers (1141.15) (2014) (0)
- MALDI Mass Spectrometry Imaging Reveals Heterogenous Distribution of Tenofovir and Tenofovir‐Diphosphate in Human Colorectal Tissue (2018) (0)
- Site‐Specific Dueteration Decreases Cytrochrome P450 Production of 12‐Hydroxy‐Nevirapine through the Kinetic Isotope Effect (2018) (0)
- Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies (2023) (0)
- An Increase in Expression of the ER Stress Responsive Protein IRE1α Occurs in Response to the Anti‐HIV Drug Efavirenz in Primary Human Hepatocytes. (2013) (0)
- Structure‐Activity Analysis of Efavirenz‐Mediated Activation of Pregnane X Receptor (2016) (0)
- L3 - Drug metabolism, pharmacogenomics and the quest to personalize HIV treatment and prevention (2020) (0)
- Antiretroviral Therapy Does Not Restore Brain Lipids During SIV Infection: Regional Analysis of Metabolic Homeostasis and Depletion (2022) (0)
- The Enzymatic Activities of Nucleoside Triphosphate Diphosphohydrolases Towards Tenofovir Diphosphate and Their Spatial Distributions in Human Colorectal Tissue (2021) (0)
- Interaction of Depot Medroxyprogesterone Acetate and Tenofovir Disoproxil Fumarate/Emtricitabine on Peripheral Blood Mononuclear Cells and Cervical Tissue Susceptibility to HIV Infection and Pharmacokinetics (2022) (0)
- Simultaneous Spatial Mapping of Emtricitabine, Tenofovir, and Efavirenz in Mouse Tissue Using MALDI Mass Spectrometry Imaging (2019) (0)
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