Nancy Bonini
#115,975
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American neuroscientist and geneticist
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Nancy Boninibiology Degrees
Biology
#9773
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#13018
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Genetics
#1415
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#1517
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Neuroscience
#2402
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#2467
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Biology
Nancy Bonini's Degrees
- PhD Genetics University of California, Berkeley
- Bachelors Biology University of California, San Diego
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Why Is Nancy Bonini Influential?
(Suggest an Edit or Addition)According to Wikipedia, Nancy M. Bonini is an American neuroscientist and geneticist, best known for pioneering the use of Drosophila as a model organism to study neurodegeneration of the human brain. Using the Drosophila model approach, Bonini's laboratory has identified genes and pathways that are important in the development and progression of neurodegenerative diseases such as Amyotrophic lateral sclerosis , Alzheimer's disease, and Parkinson's disease, as well as aging, neural injury and regeneration, and response to environmental toxins.
Nancy Bonini's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models (2006) (1278)
- Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease (2001) (1113)
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS (2010) (1095)
- Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 (1999) (859)
- Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila (1998) (663)
- Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila (2003) (655)
- The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye (1993) (570)
- Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. (2002) (559)
- Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease (1999) (436)
- Drosophila as a model for human neurodegenerative disease. (2005) (432)
- The microRNA miR-34 modulates aging and neurodegeneration in Drosophila (2012) (364)
- Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. (2000) (346)
- Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease (2005) (344)
- Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated Aggregation (1998) (342)
- A yeast functional screen predicts new candidate ALS disease genes (2011) (327)
- Therapeutic modulation of eIF2α-phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models (2013) (310)
- The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. (1997) (309)
- RNA toxicity is a component of ataxin-3 degeneration in Drosophila (2008) (305)
- Pharmacological prevention of Parkinson disease in Drosophila (2002) (285)
- DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function (2010) (266)
- Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. (2005) (262)
- Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. (2012) (250)
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. (2018) (249)
- MicroRNA pathways modulate polyglutamine-induced neurodegeneration. (2006) (240)
- Biochemical and pathological characterization of Lrrk2 (2006) (239)
- Drosophila as an In Vivo Model for Human Neurodegenerative Disease (2015) (232)
- Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging (2006) (228)
- Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila (2007) (218)
- RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways (2008) (214)
- Transcription factor YY1 functions as a PcG protein in vivo (2003) (211)
- Chaperoning brain degeneration (2002) (205)
- Mechanisms of Suppression of α-Synuclein Neurotoxicity by Geldanamycin in Drosophila* (2005) (193)
- Epigenetic Regulation in Neurodegenerative Diseases (2018) (188)
- MicroRNAs and neurodegeneration: role and impact. (2013) (180)
- Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. (2002) (178)
- Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants (2009) (171)
- Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease (2018) (171)
- Human neurodegenerative disease modeling using Drosophila. (2003) (170)
- A Drosophila Model for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1*♦ (2008) (166)
- An arginine/lysine‐rich motif is crucial for VCP/p97‐mediated modulation of ataxin‐3 fibrillogenesis (2006) (162)
- Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. (2011) (138)
- CREB-Binding Protein Modulates Repeat Instability in a Drosophila Model for PolyQ Disease (2007) (138)
- Snaring the Function of α-Synuclein (2005) (134)
- The Exoribonuclease Nibbler Controls 3′ End Processing of MicroRNAs in Drosophila (2011) (132)
- Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm. (1997) (130)
- Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-Synucleinopathies (2006) (124)
- Polyglutamine disease and neuronal cell death. (2000) (122)
- A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity (2012) (117)
- Multiple roles of the eyes absent gene in Drosophila. (1998) (116)
- An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (2020) (115)
- Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts (2016) (110)
- Regulation of ciliary motility by membrane potential in Paramecium: a role for cyclic AMP. (1986) (110)
- Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. (2005) (107)
- Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. (2000) (105)
- Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. (1997) (103)
- Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. (2006) (99)
- Differential regulation of Paramecium ciliary motility by cAMP and cGMP (1988) (97)
- PolyQ Repeat Expansions in ATXN2 Associated with ALS Are CAA Interrupted Repeats (2011) (89)
- Drosophila models of human neurodegenerative disease (2000) (88)
- Polyglutamine Genes Interact to Modulate the Severity and Progression of Neurodegeneration in Drosophila (2008) (87)
- GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function (2015) (82)
- Triplet Repeat–Derived siRNAs Enhance RNA–Mediated Toxicity in a Drosophila Model for Myotonic Dystrophy (2011) (79)
- ATXN2 trinucleotide repeat length correlates with risk of ALS (2017) (77)
- Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model (2013) (76)
- DJ‐1 is present in a large molecular complex in human brain tissue and interacts with α‐synuclein (2005) (72)
- Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain. (2000) (69)
- Snaring the function of alpha-synuclein. (2005) (69)
- Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis (2018) (68)
- A New Role for MicroRNA Pathways: Modulation of Degeneration Induced by Pathogenic Human Disease Proteins (2006) (67)
- Roles of trinucleotide-repeat RNA in neurological disease and degeneration (2010) (66)
- Transvection at the eyes absent gene of Drosophila. (1994) (65)
- Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer element. (2000) (65)
- Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence (2016) (61)
- Impact of age-associated increase in 2′-O-methylation of miRNAs on aging and neurodegeneration in Drosophila (2014) (60)
- Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila (2011) (60)
- Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3 (2009) (59)
- Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis (2011) (59)
- TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling (2017) (56)
- The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila (2015) (55)
- Axon degeneration and regeneration: insights from Drosophila models of nerve injury. (2012) (53)
- Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium. (1990) (50)
- Early decisions in Drosophila eye morphogenesis. (1995) (50)
- Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. (2019) (46)
- Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72 (2014) (45)
- Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS (2011) (41)
- The regulation of ciliary motility in Paramecium by Ca2+ and cyclic nucleotides. (1991) (40)
- Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2018) (37)
- Functional analysis of an eye enhancer of the Drosophila eyes absent gene: differential regulation by eye specification genes. (2000) (33)
- Axon Injury and Regeneration in the Adult Drosophila (2014) (32)
- Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure (1999) (32)
- MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging (2018) (29)
- eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS (2019) (29)
- Silencing Polyglutamine Degeneration with RNAi (2005) (27)
- A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster. (1999) (27)
- Dual functions of the Drosophila eyes absent gene in the eye and embryo (1998) (26)
- Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation (2018) (25)
- Fruit flies on the front line: the translational impact of Drosophila (2016) (24)
- Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing (2013) (22)
- Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila (2011) (21)
- Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients (2018) (21)
- Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila (2020) (20)
- Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies (2019) (20)
- Poly(ADP-Ribosylation) in Age-Related Neurological Disease. (2019) (19)
- Modeling human trinucleotide repeat diseases in Drosophila. (2011) (18)
- Defining Genetic Factors That Modulate Intergenerational CAG Repeat Instability in Drosophila melanogaster (2011) (17)
- Suppression of Polyglutamine Toxicity by the Yeast Sup35 Prion Domain in Drosophila* (2007) (16)
- Age-dependent patterns of microRNA RISC loading (2014) (16)
- Drosophila as a genetic approach to human neurodegenerative disease. (2001) (15)
- New Roles for Canonical Transcription Factors in Repeat Expansion Diseases. (2019) (14)
- A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1. (2015) (14)
- Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease (2018) (13)
- The Sustained Impact of Model Organisms—in Genetics and Epigenetics (2016) (13)
- Applications of the Drosophila retina to human disease modeling. (2002) (12)
- Yeast Informs Alzheimer's Disease (2011) (11)
- Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator (2020) (10)
- Repeat-associated non-AUG (RAN) translation mechanisms are running into focus for GGGGCC-repeat associated ALS/FTD (2019) (10)
- Surviving Drosophila eye development (1997) (9)
- A Tribute to Seymour Benzer, 1921–2007 (2008) (9)
- Hosting Neurotoxicity in Polyglutamine Disease (2006) (6)
- TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2. (2020) (6)
- Drosophila as a genetic tool to define vertebrate pathway players. (2000) (6)
- TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2 (2020) (6)
- Drosophila models of polyglutamine diseases. (2003) (6)
- Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction (2021) (5)
- Glial AP1 is activated with aging and accelerated by traumatic brain injury (2021) (5)
- Methods to detect patterns of cell death in Drosophila. (2000) (4)
- Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence (2021) (4)
- Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans. (2017) (4)
- Loss of miR‐34 in Drosophila dysregulates protein translation and protein turnover in the aging brain (2022) (4)
- Role and impact of the gut microbiota in a Drosophila model for parkinsonism (2019) (3)
- Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila (2022) (3)
- The use of drosophila as a model system for studying neurodegeneration (2000) (2)
- Author response: GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function (2015) (2)
- Hope on the (fruit) fly: the Drosophila wing paradigm of axon injury (2015) (2)
- Short ArticleMicroRNA Pathways Modulate Polyglutamine-Induced Neurodegeneration (2006) (2)
- Expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9or72-associated FTD (2018) (2)
- Editorial overview: Molecular & genetic basis of disease. (2017) (1)
- An Integrated Multi-omics Approach Identifies Therapeutic Potential for ATP6V1A in Late Onset Alzheimer’s Disease (2021) (1)
- Author Correction: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (2020) (1)
- Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2019) (1)
- dTBI: A paradigm for closed-head injury in Drosophila (2020) (1)
- A perspective on Drosophila genetics and its insight into human neurodegenerative disease (2022) (1)
- Cooper in Parkinson ' s Models-Synuclein Blocks ER-Golgi Traffic and Rab 1 Rescues Neuron Loss (2013) (1)
- Erratum: Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease (Journal of Neuroscience (December 1, 1999) (10338-10347)) (2000) (1)
- Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients (2018) (0)
- Stores to die for. (2001) (0)
- Drosophila Models for Parkinson's Disease Research (2008) (0)
- Ensheathing glia promote increased lifespan and healthy brain aging. (2023) (0)
- Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2019) (0)
- Human neurodegenerative disease: insights from Drosophila genetics (2008) (0)
- Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (2018) (0)
- Modulation of the Aging Drosophila Brain and Susceptibility to Neurodegeneration (2020) (0)
- MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging (2018) (0)
- Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis (2018) (0)
- Drosophila and C. elegans Models of Human Age-Associated Neurodegenerative Diseases (2006) (0)
- En Masse Analysis of Genetic Modifiers Informs Players and Processes in ALS (2019) (0)
- Glial AP1 promotes early TBI recovery but chronically drives tauopathy (2021) (0)
- Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease (2018) (0)
- Connections between cell senescence, chromatin, and neurodegeneration (2015) (0)
- Aging and Neurodegeneration: New Approaches to Neurodegeneration and Aging (2020) (0)
- PROTOFIBRILS , PORES , FIBRILS , AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders ∗ (2010) (0)
- Using Drosophila to Reveal Insight into Protein Misfolding Diseases (2010) (0)
- Allan Campbell (April 27, 1929-April 19, 2018). (2018) (0)
- Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator (2020) (0)
- Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD (2019) (0)
- Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies (2019) (0)
- eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS (2019) (0)
- Ataxin-2 expands insight into the ALS clinical spectrum (2015) (0)
- Drosophila as a Model for Neurodegenerative Disease: Roles of RNA Pathways in Pathogenesis (2010) (0)
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