Nancy Zahniser
#85,324
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American pharmacologist
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Nancy Zahnisermedical Degrees
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#2307
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#2723
Historical Rank
#455
USA Rank
Pharmacology
#399
World Rank
#452
Historical Rank
#39
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Nancy Zahniser's Degrees
- PhD Pharmacology University of California, San Francisco
Why Is Nancy Zahniser Influential?
(Suggest an Edit or Addition)According to Wikipedia, Nancy Rutledge Zahniser was an American pharmacologist, best known for her work involving the mechanism of dopaminergic pathways and chemical modifications of them. Although born in Ann Arbor, Michigan, Zahniser grew up in Chillicothe, Ohio and subsequently enrolled at the College of Wooster, where she obtained a degree in chemistry. After completing her degree, Zahniser spent some time in India where she met her first husband Mark Zahniser; she later returned to the United States to attend the University of Pittsburgh School of Pharmacy, where she earned her PhD in pharmacology in 1977. Zahniser went on to complete her post-doctoral training at the University of Colorado Health Sciences Center's Department of Pharmacology and then became a part of the faculty there. In 2007, she became associate dean for research education. She played a role in advancing the careers of many post-doctoral students in her lab. In addition to her work as a professor, Zahniser was also a member of several boards, committees, review panels, and professional societies related to pharmacology, neuroscience, and addiction. She led several national research meetings from 1995-2002.
Nancy Zahniser's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants (1997) (457)
- Chronic and acute regulation of Na+/Cl- -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. (2001) (307)
- Structural differences between insulin receptors in the brain and peripheral target tissues. (1983) (257)
- Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis (1998) (240)
- Dopamine D2 Receptor‐Deficient Mice Exhibit Decreased Dopamine Transporter Function but No Changes in Dopamine Release in Dorsal Striatum (1999) (239)
- Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. (1990) (214)
- Oligomerization of Dopamine Transporters Visualized in Living Cells by Fluorescence Resonance Energy Transfer Microscopy* (2003) (198)
- RNA Interference Screen Reveals an Essential Role of Nedd4–2 in Dopamine Transporter Ubiquitination and Endocytosis (2006) (197)
- Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes. (1997) (190)
- Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. (1990) (184)
- Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells (2011) (181)
- Effect of guanine nucleotides on striatal dopamine receptors (1978) (175)
- Constitutive and Protein Kinase C‐Induced Internalization of the Dopamine Transporter is Mediated by a Clathrin‐Dependent Mechanism (2005) (171)
- Amphetamine and Methamphetamine Differentially Affect Dopamine Transporters in Vitro and in Vivo* (2009) (165)
- DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling (2014) (159)
- Differences in Dopamine Clearance and Diffusion in Rat Striatum and Nucleus Accumbens Following Systemic Cocaine Administration (1992) (157)
- Binding characteristics of the dopamine uptake inhibitor [3H]nomifensine to striatal membranes. (1985) (137)
- Rapid regulation of the dopamine transporter: role in stimulant addiction? (2004) (136)
- Adenosine A2a Receptor Modulation of Electrically Evoked Endogenous GABA Release from Slices of Rat Globus Pallidus (1993) (125)
- In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. (1999) (115)
- Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent. (2001) (109)
- Modulation of Hippocampal Glutamatergic Transmission by ATP Is Dependent on Adenosine A1 Receptors (2002) (108)
- Opposing actions of adenosine A2a and dopamine D2 receptor activation on GABA release in the basal ganglia: Evidence for an A2a/D2 receptor interaction in globus pallidus (1996) (108)
- Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands. (2003) (107)
- Characterization and Regulation of Insulin Receptors in Rat Brain (1984) (105)
- Robust modulation of [3H]dopamine release from rat striatal slices by D-2 dopamine receptors. (1986) (100)
- Dopamine Transport by the Serotonin Transporter: A Mechanistically Distinct Mode of Substrate Translocation (2011) (96)
- Effects of ethanol administration and withdrawal on neurotransmitter receptor systems in C57 mice. (1980) (96)
- Brief, repeated exposure to substrates down‐regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo (2002) (93)
- Functional Uncoupling of Adenosine A2A Receptors and Reduced Response to Caffeine in Mice Lacking Dopamine D2Receptors (2000) (91)
- The use of 14C-labeled tissue paste standards for the calibration of 125I-labeled ligands in quantitative autoradiography (1987) (86)
- Repeated cocaine administration results in supersensitivity of striatal D-2 dopamine autoreceptors to pergolide. (1988) (81)
- Trafficking of dopamine transporters in psychostimulant actions. (2009) (79)
- Mechanisms of acute cocaine toxicity. (2008) (79)
- Individual Differences in Cocaine-Induced Locomotor Sensitization in Low and High Cocaine Locomotor-Responding Rats Are Associated with Differential Inhibition of Dopamine Clearance in Nucleus Accumbens (2003) (74)
- Comparison of dopamine receptor sites labeled by [3H]-S-sulpiride and [3H]-spiperone in striatum. (1983) (74)
- Attention-Deficit/Hyperactivity Disorder: Is it time to Reappraise the Role of Sugar Consumption? (2011) (73)
- Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process. (1986) (73)
- Acute Cocaine Differentially Alters Accumbens and Striatal Dopamine Clearance in Low and High Cocaine Locomotor Responders: Behavioral and Electrochemical Recordings in Freely Moving Rats (2002) (72)
- Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. (2001) (71)
- Quantitative autoradiography of 3H-nomifensine binding sites in rat brain. (1985) (71)
- Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum (1992) (67)
- Individual Differences in Cocaine-induced Locomotor Activity in Rats: Behavioral Characteristics, Cocaine Pharmacokinetics, and the Dopamine Transporter (2003) (66)
- One injection of cocaine produces a long-lasting increase in [3H]-dopamine release (1987) (66)
- Kinetic analysis of striatal clearance of exogenous dopamine recorded by chronoamperometry in freely-moving rats (2002) (64)
- Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of unrestrained rats (2003) (62)
- Negative Regulation of Dopamine Transporter Endocytosis by Membrane-Proximal N-Terminal Residues (2009) (61)
- Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats (2007) (61)
- In VivoElectrochemical Studies of Dopamine Clearance in Subregions of Rat Nucleus Accumbens: Differential Properties of the Core and Shell (1998) (57)
- Rapid substrate‐induced down‐regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens (2009) (51)
- Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat. (1999) (51)
- Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. (1977) (50)
- Molecular physiology and regulation of catecholamine transporters. (1998) (48)
- Persistent augmented dopamine release after acute cocaine requires dopamine receptor activation (1989) (44)
- Low or High Cocaine Responding Rats Differ in Striatal Extracellular Dopamine Levels and Dopamine Transporter Number (2009) (42)
- Individual differences in cocaine-induced locomotor activity in male Sprague–Dawley rats and their acquisition of and motivation to self-administer cocaine (2008) (41)
- A new densitometric procedure to measure protein levels in tissue slices used in quantitative autoradiography (1988) (41)
- Individual Differences in Cocaine- and Amphetamine-Induced Activation of Male Sprague–Dawley Rats: Contribution of the Dopamine Transporter (2004) (39)
- Decreased efficacy of inositol 1,4,5-trisphosphate to elicit calcium mobilization from cerebrocortical microsomes of aged rats. (1990) (39)
- Long-Term Treatment of Male F344 Rats with Deprenyl: Assessment of Effects on Longevity, Behavior, and Brain Function (1997) (39)
- Conventional protein kinase C isoforms regulate human dopamine transporter activity in Xenopus oocytes (2002) (38)
- Voltage-dependency of the dopamine transporter in the rat substantia nigra (1999) (36)
- Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors (2013) (36)
- Brain neurotransmitter receptor systems in mice genetically selected for differences in sensitivity to ethanol (1980) (36)
- Confirmation and Fine Mapping of Ethanol Sensitivity Quantitative Trait Loci, and Candidate Gene Testing in the LXS Recombinant Inbred Mice (2006) (35)
- Thermodynamic differences between agonist and antagonist interactions with binding sites for [3H]spiroperidol in rat striatum. (1983) (35)
- Chemical kindling decreases GABA-activated chloride channels of mouse brain. (1989) (34)
- Cocaine levels in striatum and nucleus accumbens: Augmentation following challenge injection in rats withdrawn from repeated cocaine administration (1993) (31)
- Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely-moving rats (1999) (31)
- Electrophysiological effects of cocaine in the rat hippocampus in vitro (1984) (30)
- Sensitization to cocaine in the nigrostriatal dopamine system. (1988) (29)
- Quantitative autoradiographic analysis of 125I-pindolol binding in Fischer 344 rat brain: Changes in β-adrenergic receptor density with aging (1988) (28)
- Outflow and overflow of picogram levels of endogenous dopamine and DOPAC from rat striatal slices: improved methodology for studies of stimulus-evoked release and metabolism (1989) (28)
- Persistence of ß-adrenergic receptors in rat striatum following kainic acid administration (1979) (27)
- Acetylcholine and Choline in Human Plasma and Red Blood Cells: A Gas Chromatograph Mass Spectrometric Evaluation (1978) (27)
- An improved calibration procedure for computer-based quantitative autoradiography utilizing a mathematical model for the non-linear response of camera and film (1988) (27)
- Biphasic modulation of evoked [3H]D‐aspartate release by D‐2 dopamine receptors in rat striatal slices (1988) (26)
- Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo (2007) (26)
- DSP4-induced noradrenergic lesions increase β-adrenergic receptors and hippocampal electrophysiological responsiveness (1986) (26)
- Inhibition of striatal dopamine release by the selective D‐2 dopamine receptor agonist N‐0437 is blocked by quinine (1990) (25)
- Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats (1995) (24)
- Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. (2005) (23)
- A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior (2014) (23)
- Effect of aging on alpha-1 adrenergic stimulation of phosphoinositide hydrolysis in various regions of rat brain. (1990) (23)
- Inhibitors of arachidonic acid metabolism: effects on rat striatal dopamine release and uptake. (1991) (22)
- Locomotor activity induced by noncompetitive NMDA receptor antagonists versus dopamine transporter inhibitors: opposite strain differences in inbred long-sleep and short-sleep mice. (2002) (22)
- Behavioural sensitivity to PIA in selectively bred mice is related to a number of A1 adenosine receptors but not to cyclic AMP accumulation in brain slices. (1985) (22)
- GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain. (1992) (21)
- Electrophysiological and biochemical sequelae of the destruction of hippocampal noradrenergic afferents by DSP4 (1983) (21)
- Effects of cell isolation procedures and radioligand selection on the characterization of human leukocyte beta-adrenergic receptors. (1987) (20)
- Low and high cocaine locomotor responding male Sprague–Dawley rats differ in rapid cocaine-induced regulation of striatal dopamine transporter function (2010) (20)
- Differences in Rat Dorsal Striatal NMDA and AMPA Receptors following Acute and Repeated Cocaine-Induced Locomotor Activation (2012) (19)
- N-methyl-D-aspartate receptor responses are differentially modulated by noncompetitive receptor antagonists and ethanol in inbred long-sleep and short-sleep mice: behavior and electrophysiology. (2000) (19)
- Differences in NMDA receptor antagonist-induced locomotor activity and [3H]MK-801 binding sites in short-sleep and long-sleep mice. (1998) (19)
- Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes. (1994) (19)
- Repeated intravenous cocaine administration to rats produces behavioral sensitization without changing brain cocaine levels (1994) (19)
- Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum (1990) (18)
- Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity (2009) (17)
- Voltage-dependency of the dopamine transporter in rat brain. (1998) (17)
- Differences in bingeing behavior and cocaine reward following intermittent access to sucrose, glucose or fructose solutions (2015) (16)
- Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine (2012) (16)
- Autoradiographic Visualization and Quantification of Dopamine Receptors and Uptake Sites in the Rat and Human CNS (1986) (16)
- Diazepam sensitizes mice to FG 7142 and reduces muscimol-stimulated 36Cl− flux (1989) (16)
- High-speed chronoamperometric electrochemical measurements of dopamine clearance. (1998) (16)
- Individual differences in initial low-dose cocaine-induced locomotor activity and locomotor sensitization in adult outbred female Sprague–Dawley rats (2009) (15)
- Propafenone interacts stereoselectively with beta 1- and beta 2-adrenergic receptors. (1988) (14)
- Modulation of γ-[3H]aminobutyric acid release from rat cortical slices by α 2-adrenoceptors (1987) (13)
- [35S]TBPS binding sites are decreased in the colliculi of mice with a genetic predisposition to bicuculline-induced seizures (1989) (13)
- Comparison between the effects of aging on antagonist and agonist interactions with beta-adrenergic receptors on human mononuclear and polymorphonuclear leukocyte membranes. (1988) (12)
- Low- and high-cocaine locomotor responding rats differ in reinstatement of cocaine seeking and striatal mGluR5 protein expression (2013) (10)
- Cocaine Dose and Self-Administration History, but Not Initial Cocaine Locomotor Responsiveness, Affects Sensitization to the Motivational Effects of Cocaine in Rats (2012) (10)
- Quantitative Autoradiographic Localization of Dopamine Receptors and Uptake Sites in the Rat and Human CNS (1985) (9)
- Lack of an effect of age on beta-adrenoceptor-mediated lipolysis in isolated human adipocytes. (1999) (9)
- MK-801-induced locomotor activity in long-sleep x short-sleep recombinant inbred mouse strains: correlational analysis with low-dose ethanol and provisional quantitative trait loci. (1999) (9)
- Individual differences in cocaine-induced locomotor activity of male Sprague–Dawley rats are not explained by plasma corticosterone levels (2010) (8)
- Using High-Speed Chronoamperometry with Local Dopamine Application to Assess Dopamine Transporter Function (2007) (8)
- Timolol‐induced up‐regulation of polymorphonuclear leukocyte β2‐adrenergic receptors in the elderly (1989) (8)
- On the selection of mice for haloperidol response and non-response (2005) (8)
- MK-801- and ethanol-induced activity in inbred long-sleep and short-sleep mice: dopamine and serotonin systems. (2002) (8)
- Medical Faculty Development: A Modern-Day Odyssey (2011) (7)
- The acute effects of 6-hydroxydopamine treatment on noradrenergic function in the rat hippocampus in vitro (1986) (7)
- Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine (1988) (6)
- Signal transduction pathways involved in presynaptic receptor-mediated inhibition of dopamine release in rat striatum (1992) (6)
- Binding of [3H]amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene to rat striatal membranes. Effects of purine nucleotides and ultraviolet irradiation. (1981) (6)
- Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption (2010) (5)
- Differential regulation of cocaine-induced locomotor activity in inbred long-sleep and short-sleep mice by dopamine and serotonin systems. (2004) (5)
- Role of the Dopamine Transporter in the Differential Cocaine-Induced Locomotor Activation of Inbred Long-Sleep and Short-Sleep Mice (2004) (5)
- Tonic and Phasic Amperometric Monitoring of Dopamine Using Microelectrode Arrays in Rat Striatum (2020) (4)
- Teaching Corporate in College (2014) (4)
- Repeated Cocaine Administration Results in Supersensitive Nigrostriatal D-2 Dopamine Autoreceptors (1988) (4)
- JPET # 103572 1 TITLE PAGE Confirmation and Fine Mapping of Ethanol Sensitivity QTLs , and Candidate Gene Testing in the LXS Recombinant Inbred Mice (2006) (3)
- Erratum to: Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine (2012) (2)
- Regultion of adrenergic receptors in intraocular hippocampal transplants: Role of Noradrenergic Innervation (1990) (2)
- Short Communication Propafenone Interacts Stereoselectively with β1 and β2-Adrenergic Receptors (1989) (1)
- Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine (2011) (1)
- Erratum to: Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine (2012) (1)
- P12 CGS 21680 increases electrically-evoked endogenous GABA from slices of rat striatum and globus pallidus (1992) (0)
- Acknowledgment to Reviewers (2006) (0)
- Cocaine Administration: D1 Dopamine Receptor Function and Dopamine Clearance/Diffusion in Rat Striatum and Nucleus Accumbens a (1992) (0)
- Cocaine‐induced locomotor sensitization persists in rats that escalate cocaine self‐administration in a short‐access procedure (848.6) (2014) (0)
- Individual Differences to Cocaine‐Induced Activation in Rats: Striatal Dopamine D1 and D2 Receptors (2010) (0)
- High cocaine locomotor responding rats have greater hippocampal norepinephrine transporter function than low cocaine locomotor responding rats after acute cocaine exposure (2011) (0)
- Modulation of GABA release in rat basal ganglia Antagonistic adenosine A-1/dopamine D-1 receptor interaction? (1996) (0)
- Activation of Protein Kinase C Inhibits Uptake , Currents and Binding Associated with the Human Dopamine Transporter Expressed in Xenopus Oocytes 1 (1997) (0)
- Irreversible inhibition of rat striatal dopamine uptake induced by in vitro exposure to DSP4. (1989) (0)
- Effects of aging on antagonist and agonist interactions with. beta. -adrenergic receptors on human leukocyte membranes (1986) (0)
- [3H]-Nomifensine Labels Sites Associated with Neuronal Uptake Pumps for Both Dopamine and Norepinephrine in the CNS (1986) (0)
- Multiple receptors mediate adenosine actions in rat hippocampus and striatum: effects of selective adenosine A1 and A2 receptor agonists (1990) (0)
- Rapid substrate‐induced down‐regulation of rat dopamine transporter function in vitro: dorsal striatum vs. nucleus accumbens (2008) (0)
- Maintenanceof late-phase LTP isaccompaniedby PKA-dependent increase in AMPAreceptorsynthesis (0)
- Functional Roles of A1 and A2 Receptors in Rat Hippocampus and Striatum (1990) (0)
- Drug Addiction. (1953) (0)
- Differential cocaine‐induced changes in striatal glutamate receptor phosphorylation in low and high cocaine responding rats (2010) (0)
- PRECURSOR OF BRAIN ACETYLCHOLINE ? A GAS CHROMATOGRAPHIC EVALUATION 1 ’ 2 (2005) (0)
- Low cocaine responding rats have a greater basal number of hippocampal norepinephrine transporters than high cocaine responding rats (2010) (0)
- UNIVERSITY OF COLORADO DENVER ANSCHUTZ MEDICAL CAMPUS 26th ANNUAL STUDENT RESEARCH FORUM and STUDENT RESEARCH AWARDS CONVOCATION College of Nursing GRADUATE SCHOOL SCHOOL OF MEDICINE SCHOOL OF PHARMACY SCHOOL OF PUBLIC HEALTH (2011) (0)
- Terbutaline‐induced desensitization of polymorphonuclear leukocyte β2‐adrenergic receptors in young and elderly subjects (1992) (0)
- Lipolysis in Isolated Human Adipocytes (1999) (0)
- Individual differences to cocaine activation and self‐administration in rats: role of the brain dopamine transporter (2008) (0)
- Modulation of gamma-[3H]aminobutyric acid release from rat cortical slices by alpha 2-adrenoceptors. (1987) (0)
- Effects of cocaine exposure on striatal extracellular glutamate and cell surface ionotropic glutamate receptors in low and high cocaine responding rats (2011) (0)
- Cortical areaMT and theperception of stereoscopicdepth (0)
- Age-related changes in α1-adrenergic receptors and associated signaling systems in rat brain (1990) (0)
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