Naofumi Mukaida

Q: What Schools Are Affiliated With Naofumi Mukaida

Naofumi Mukaida is affiliated with the following schools: Kanazawa University, University of Tokyo, Jichi Medical University, Institute of Science Tokyo, Osaka University, University of North Carolina at Chapel Hill, New York University, Wakayama Medical University, Kyoto University, Aarhus University, Kanazawa Medical University, Hokkaido University

Naofumi Mukaida's AcademicInfluence.com Rankings

Naofumi Mukaida

Computer Science

#4488

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#4734

Historical Rank

Computational Linguistics

#443

World Rank

#450

Historical Rank

Machine Learning

#894

World Rank

#906

Historical Rank

Artificial Intelligence

#1109

World Rank

#1128

Historical Rank

computer-science Degrees

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Computer Science

Naofumi Mukaida's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Naofumi Mukaida's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Properties of the novel proinflammatory supergene "intercrine" cytokine family. (1991) (1904)
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. (1993) (1001)
Essential involvement of interleukin‐8 (IL‐8) in acute inflammation (1994) (976)
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. (2008) (832)
Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. (1990) (664)
Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8 (1993) (546)
Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. (1989) (515)
Essential involvement of IL‐6 in the skin wound‐healing process as evidenced by delayed wound healing in IL‐6‐deficient mice (2003) (489)
Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. (1992) (474)
Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. (2003) (468)
[Molecular mechanism of interleukin-8 gene expression]. (1994) (413)
Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. (1994) (409)
Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. (2008) (393)
Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions. (1998) (392)
Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. (2000) (346)
Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response (2001) (346)
Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. (2000) (339)
Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45 (1997) (299)
IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoyl Homoserine Lactone Is Transcriptionally Regulated by NF-κB and Activator Protein-21 (2001) (284)
Accelerated wound healing in tumor necrosis factor receptor p55‐deficient mice with reduced leukocyte infiltration (2002) (265)
Constitutive activation of transcription factors NF‐κB, AP‐1, and NF‐IL6 in human head and neck squamous cell carcinoma cell lines that express pro‐inflammatory and pro‐angiogenic cytokines (1999) (260)
Blockade of CCR2 ameliorates progressive fibrosis in kidney. (2004) (245)
CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status (2012) (242)
CCR2 signaling contributes to ischemia-reperfusion injury in kidney. (2003) (232)
Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. (1991) (219)
Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP‐1) (1996) (214)
Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. (1996) (213)
Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. (1992) (210)
Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. (2013) (201)
A pivotal involvement of IFN‐' in the pathogenesis of acetaminophen‐induced acute liver injury (2002) (200)
The Essential Involvement of Cross-Talk between IFN-γ and TGF-β in the Skin Wound-Healing Process1 (2004) (194)
IL (Interleukin)-1α Promotes Nuclear Factor-κB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas (2001) (193)
Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. (2009) (192)
Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-kappa B and NF-IL-6. (1996) (181)
IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. (1991) (176)
Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. (2004) (175)
Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells (2010) (171)
Elevated interleukin-8 levels in the urine of patients with urinary tract infections (1993) (167)
Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene (1997) (162)
Monocyte chemoattractant protein‐1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas (2002) (161)
Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8. (1997) (160)
Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. (2007) (160)
Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vitro. (1995) (158)
Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-κB Activation and a Reciprocal Suppression of TGF-β Signal Pathway1 (2006) (157)
Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium. (1998) (155)
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. (2006) (155)
Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice (1999) (155)
Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients. (1997) (154)
Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. (2000) (148)
MIP-1alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis. (1999) (143)
Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis (1994) (140)
Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. (2012) (139)
The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. (1994) (138)
Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. (2003) (136)
DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization (2016) (135)
Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production. (1999) (133)
Crucial Contribution of Thymic Sirpα+ Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner (2009) (132)
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells. (1999) (131)
Properties of Pro‐Inflammatory Cell Type‐Specific Leukocyte Chemotactic Cytokines, Interleukin 8 (IL‐8) and Monocyte Chemotactic and Activating Factor (MCAF) (1992) (129)
IL-8 Reduced Tumorigenicity of Human Ovarian Cancer In Vivo Due to Neutrophil Infiltration1 (2000) (129)
Enhanced AP-1 and NF-kappaB activities and stability of interleukin 8 (IL-8) transcripts are implicated in IL-8 mRNA superinduction in lung epithelial H292 cells. (1998) (124)
The α Chemokine, Interleukin 8, Inhibits the Antiviral Action of Interferon α (1997) (124)
Molecular mechanism of interleukin‐8 gene expression (1994) (123)
Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases. (1996) (122)
Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. (2000) (122)
Protection against lethal bacterial infection in mice by monocyte-chemotactic and -activating factor (1994) (121)
Detection of urinary interleukin-8 in glomerular diseases. (1994) (121)
Crucial Involvement of Tumor-Associated Neutrophils in the Regulation of Chronic Colitis-Associated Carcinogenesis in Mice (2012) (118)
Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride‐treated IL‐6‐deficient mice (1999) (116)
Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia (2004) (115)
Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site (1994) (115)
Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration. (1995) (114)
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen‐induced acute liver injury (2006) (113)
Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. (2002) (113)
A sensitive enzyme-linked immunosorbent assay for human interleukin-8. (1992) (112)
Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment (2005) (111)
Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or tumor necrosis factor. (1991) (111)
Stimulation of Interleukin-8 Production by Okadaic Acid and Vanadate in a Human Promyelocyte Cell Line, an HL-60 Subline (1997) (110)
Interleukin-1β stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells (2004) (110)
Urinary levels of chemokines (MCAF/MCP‐1, IL‐8) reflect distinct disease activities and phases of human IgA nephropathy (1998) (110)
The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen‐induced liver injury in mice (2004) (109)
Proto‐oncogene, Pim‐3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad‐mediated apoptosis (2007) (109)
The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. (2004) (108)
TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells (2014) (108)
Attenuation of monosodium urate crystal‐induced arthritis in rabbits by a neutralizing antibody against interleukin‐8 (1997) (107)
Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. (1999) (105)
IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas. (2001) (105)
Essential Involvement of IFN-γ in Clostridium difficile Toxin A-Induced Enteritis1 (2004) (104)
Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment (2014) (102)
Alkali-Induced Corneal Neovascularization Is Independent of CXCR2-Mediated Neutrophil Infiltration (2007) (101)
Regulatory mechanisms for production of IFN-gamma and TNF by antitumor T cells or macrophages in the tumor-bearing state. (1995) (100)
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. (2009) (100)
Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter (1997) (99)
Fas Ligand Induces Cell-autonomous NF-κB Activation and Interleukin-8 Production by a Mechanism Distinct from That of Tumor Necrosis Factor-α* (2004) (97)
Role of P38 MAPK, AP-1, and NF-κB in interleukin-1β-induced IL-8 expression in human vascular smooth muscle cells (2002) (97)
Inhibition of neutrophil-mediated acute inflammatory injury by an antibody against interleukin-8 (IL-8) (1998) (96)
Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice. (1995) (96)
Aberrant expression of serine/threonine kinase Pim‐3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines (2005) (96)
The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein‐2 in primary listeriosis in mice (1999) (95)
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression (2006) (95)
Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway. (2006) (95)
Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. (1998) (95)
Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury. (2003) (95)
Differential Regulation of Chemokine Gene Expression by 15-Deoxy-Δ12,1412,14 Prostaglandin J21 2 (2001) (95)
A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. (2002) (94)
Preparation of specific polyclonal antibodies to a C‐C chemokine receptor, CCR1, and determination of CCR1 expression on various types of leukocytes (1996) (93)
Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine(s). (1998) (93)
Expression of both types of human interleukin‐8 receptors on mature neutrophils, monocytes, and natural killer cells (1995) (90)
Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis (1997) (90)
Enhancement human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8 (1994) (88)
CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. (2001) (86)
Chemokines in tumor development and progression. (2012) (86)
Preparation of specific antibodies against murine IL‐1ra and the establishment of IL‐1ra as an endogenous regulator of bacteria‐induced fulminant hepatitis in mice (1995) (86)
Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell‐free system targeting NF‐κB and regulation of cytokine production/action through β2 integrin in vivo (1996) (85)
Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. (1992) (85)
Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbits by a monoclonal antibody to IL-8. (1997) (84)
Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas. (2003) (84)
Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily (2004) (84)
Pivotal role of interleukin‐8 in the acute respiratory distress syndrome and cerebral reperfusion injury (1997) (83)
Establishment of Lipopolysaccharide-dependent Nuclear Factor κB Activation in a Cell-free System (*) (1995) (82)
Essential involvement of interleukin-8 in neutrophil recruitment in rabbits with acute experimental arthritis induced by lipopolysaccharide and interleukin-1. (1994) (82)
Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-alpha. (1998) (82)
Met Kinase Inhibitor E7050 Reverses Three Different Mechanisms of Hepatocyte Growth Factor–Induced Tyrosine Kinase Inhibitor Resistance in EGFR Mutant Lung Cancer (2012) (82)
Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-κB Activation1 (2008) (82)
Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. (2003) (79)
p38 MAPK phosphorylation and NF‐κB activation in human crescentic glomerulonephritis (2002) (77)
Human T-Cell Leukemia Virus Type I Tax Transactivates Human Interleukin 8 Gene through Acting Concurrently on AP-1 and Nuclear Factor-κB-like Sites (1998) (76)
T helper 2 cytokines differently regulate monocyte chemoattractant protein-1 production by human peripheral blood monocytes and alveolar macrophages. (1996) (76)
Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. (2002) (74)
Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. (2011) (74)
CCL3-CCR5 Axis Regulates Intratumoral Accumulation of Leukocytes and Fibroblasts and Promotes Angiogenesis in Murine Lung Metastasis Process1 (2008) (73)
Expression of recombinant rabbit IL-8 in Escherichia coli and establishment of the essential involvement of IL-8 in recruiting neutrophils into lipopolysaccharide-induced inflammatory site of rabbit skin. (1993) (73)
Recombinant human growth-regulated oncogene-alpha induces T lymphocyte chemotaxis. A process regulated via IL-8 receptors by IFN-gamma, TNF-alpha, IL-4, IL-10, and IL-13. (1995) (73)
Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. (2007) (71)
Pathogenic Roles of Tumor Necrosis Factor Receptor p55–Mediated Signals in Dimethylnitrosamine-Induced Murine Liver Fibrosis (2002) (70)
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates (2013) (69)
Distinct Expression of CCR1 and CCR5 in Glomerular and Interstitial Lesions of Human Glomerular Diseases (2000) (68)
Crucial involvement of the CCL3‐CCR5 axis‐mediated fibroblast accumulation in colitis‐associated carcinogenesis in mice (2014) (68)
Role of NF-κB and AP-1 on Helicobater pylori-Induced IL-8 Expression in AGS Cells (2003) (68)
Interleukin-8 and MCAF: Novel Leukocyte Recruitment and Activating Cytokines (Part 1 of 2) (1992) (67)
A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice (1996) (66)
The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B). (1997) (66)
Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. (1998) (65)
Prevention of adenocarcinoma colon 26-induced cachexia by interleukin 10 gene transfer. (1997) (65)
Roles of Pim‐3, a novel survival kinase, in tumorigenesis (2011) (64)
Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6‐deficient mice following chronic exposure to aerosolized antigen (2004) (64)
Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. (2006) (64)
Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha. (2010) (64)
Aberrant Pim-3 expression is involved in gastric adenoma–adenocarcinoma sequence and cancer progression (2008) (64)
CCR 5 Plays a Critical Role in Obesity-Induced Adipose Tissue In fl ammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M 1 / M 2 Status (2012) (64)
Essential Involvement of CX3CR1-Mediated Signals in the Bactericidal Host Defense during Septic Peritonitis1 (2008) (64)
Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1alpha by interacting mainly with a C-C chemokine receptor, CCR1. (1997) (63)
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by interleukin-1 receptor antagonist IL-1Ra (2019) (63)
Crucial involvement of the CX3CR1‐CX3CL1 axis in dextran sulfate sodium‐mediated acute colitis in mice (2010) (63)
Modulation of Tumor Necrosis Factor and Interleukin-1-dependent NF-κB Activity by mPLK/IRAK* (1999) (62)
Selective expression of monocyte chemotactic and activating factor/monocyte chemoattractant protein 1 in human blood monocytes by Mycobacterium tuberculosis. (1994) (62)
Increase of chemokine levels in sputum precedes exacerbation of acute asthma attacks (1996) (62)
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver (2010) (60)
Induction of Dendritic Cell Differentiation by Granulocyte-Macrophage Colony-Stimulating Factor, Stem Cell Factor, and Tumor Necrosis Factor α In Vitro From Lineage Phenotypes-Negative c-kit+ Murine Hematopoietic Progenitor Cells (1997) (60)
Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in Vivo (2004) (60)
NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells. (1999) (59)
Interleukin 1 (IL 1)-dependent lymphokine production by human leukemic T cell line HSB.2 subclones. (1985) (59)
MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine (2015) (57)
Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis (2002) (55)
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis. (2016) (55)
Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha. (2004) (54)
Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis. (2001) (54)
Regulation of IL-8 production and the characteristics of the receptors for IL-8. (1992) (53)
Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation (2016) (53)
Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. (2001) (53)
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. (2002) (53)
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 (2018) (52)
Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis (2014) (52)
Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines. (1999) (51)
A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats. (2000) (51)
Chemotaxis and IL-8 receptor expression in B cells from normal and HIV-infected subjects. (1997) (51)
Enhanced mobilization of hematopoietic progenitor cells by mouse MIP‐2 and granulocyte colony‐stimulating factor in mice (1997) (51)
Prolonged recurrence‐free survival following OK432‐stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization (2011) (51)
Combined therapy of multidrug‐resistant human lung cancer with anti‐P‐glycoprotein antibody and monocyte chemoattractant protein‐1 gene transduction: The possibility of immunological overcoming of multidrug resistance (1997) (50)
PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells. (2000) (50)
The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression. (2000) (48)
Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization (2006) (48)
Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. (2012) (48)
Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma. (2015) (48)
Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines. (1998) (48)
IFN-γ Protects Cerulein-Induced Acute Pancreatitis by Repressing NF-κB Activation1 (2007) (47)
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression1 (2008) (47)
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia (2013) (47)
Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety (2007) (47)
Endotoxin-induced uveitis is partially inhibited by anti-IL-8 antibody treatment. (1999) (46)
Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. (2013) (46)
Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion (2003) (45)
Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice. (2000) (45)
Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration (2017) (45)
Potential involvement of IL‐8 in the pathogenesis of human cytomegalovirus infection (1998) (45)
Chemokines in bronchoalveolar lavage fluid in summer-type hypersensitivity pneumonitis. (1995) (45)
Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor. (1994) (44)
Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression (2020) (44)
CCL4 Signaling in the Tumor Microenvironment. (2020) (43)
Treatment with a monoclonal antibody to IL‐8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally (2000) (43)
Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion. (2019) (43)
Regulation of human interleukin 8 gene expression and binding of several other members of the intercrine family to receptors for interleukin-8. (1991) (42)
Fibroblasts, an inconspicuous but essential player in colon cancer development and progression. (2016) (42)
Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of superoxide radicals. (1993) (41)
N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1α by Human Gastric Cancer Cells* (2013) (41)
Opposite Roles of CCR2 and CX3CR1 Macrophages in Alkali-Induced Corneal Neovascularization (2009) (41)
Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55 (2004) (41)
Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53. (2001) (41)
Expression of inflammatory cytokines and adhesion molecules in haemodialysis-associated amyloidosis. (1995) (40)
Tumor cell apoptosis induces tumor‐specific immunity in a CC chemokine receptor 1‐ and 5‐dependent manner in mice (2008) (39)
Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. (2004) (39)
Prevention of endotoxin shock by an antibody against leukocyte integrin beta 2 through inhibiting production and action of TNF. (1995) (38)
Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production1 (2005) (38)
A Novel Regulatory Mechanism of Pim-3 Kinase Stability and Its Involvement in Pancreatic Cancer Progression (2013) (38)
Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney (2011) (38)
Induction and regulation of IL-8 and MCAF production in human brain tumor cell lines and brain tumor tissues. (1993) (38)
Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice (2015) (38)
Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. (2009) (38)
Anti-interleukin-8 monoclonal antibody reduces free radical production and improves hemodynamics and survival rate in endotoxic shock in rabbits. (1997) (37)
Essential contribution of Ets‐1 to constitutive Pim‐3 expression in human pancreatic cancer cells (2009) (37)
Intrahepatic interleukin-8 production during disease progression of chronic hepatitis C. (2007) (37)
Detection of mouse IL‐8 receptor homologue expression on peripheral blood leukocytes and mature myeloid lineage cells in bone marrow (1996) (37)
MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice. (2005) (37)
CCL2-mediated reversal of impaired skin wound healing in diabetic mice by normalization of neovascularization and collagen accumulation. (2019) (36)
The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. (2010) (36)
Protein kinase R, IκB kinase-β and NF-κB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells (2007) (36)
Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4 (2018) (35)
Pivotal roles of interleukin‐6 in transmural inflammation in murine T cell transfer colitis (2004) (35)
Optimal amount of monocyte chemoattractant protein‐1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation (2008) (35)
Differential effects of anti‐inflammatory cytokines (IL‐4, IL‐10 and IL‐13) on tumoricidal and chemotactic properties of human monocytes induced by monocyte chemotactic and activating factor (1995) (35)
Dexamethasone impairs pulmonary defence against Pseudomonas aeruginosa through suppressing iNOS gene expression and peroxynitrite production in mice (2001) (35)
Enhancement of tumor‐specific T‐cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma (2009) (35)
Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma (2006) (35)
IL-1β induces IL-8 in bronchial cells via NF-κB and NF-IL6 transcription factors and can be suppressed by glucocorticoids (2005) (34)
Rapid secretion of intracellularly pre‐stored interleukin‐8 from rabbit platelets upon activation (1996) (34)
Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells (2007) (34)
Prevention of endotoxin-induced acute lethality in Propionibacterium acnes-primed rabbits by an antibody to leukocyte integrin beta 2 with concomitant reduction of cytokine production (1995) (34)
ERβ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells (2011) (33)
Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1 (1997) (32)
Interferon-γ is protective in cisplatin-induced renal injury by enhancing autophagic flux. (2012) (32)
Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. (2002) (32)
Induction of inflammatory cytokines in the pleural effusion of cancer patients after the administration of an immunomodulator, OK-432: role of IL-8 for neutrophil infiltration. (1993) (31)
Protective Roles of CX3CR1-Mediated Signals in Toxin A-Induced Enteritis through the Induction of Heme Oxygenase-1 Expression (2011) (31)
Preparation and characterization of polyclonal and monoclonal antibodies against human interleukin 1 alpha (IL 1 alpha). (1987) (31)
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. (2016) (30)
Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer (2006) (30)
Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist (2009) (30)
Critical role of SDF-1α-induced progenitor cell recruitment and macrophage VEGF production in the experimental corneal neovascularization (2011) (30)
Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia (2017) (29)
Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma (2001) (29)
Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. (2007) (29)
Interleukin-8 selectively enhances cytopathic effect (CPE) induced by positive-strand RNA viruses in the human WISH cell line. (1997) (28)
Gastrin induces CXC chemokine expression in gastric epithelial cells through activation of NF-kappaB. (2001) (28)
Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein. (1992) (27)
Essential Role of Transcription Factor Nuclear Factor-κB in Regulation of Interleukin-8 Gene Expression by Nitrite Reductase from Pseudomonas aeruginosa in Respiratory Epithelial Cells (1999) (27)
Absence of IFN‐gamma accelerates thrombus resolution through enhanced MMP‐9 and VEGF expression (2009) (27)
Monocyte chemoattractant protein-1 stimulates tumor necrosis and recruitment of macrophages into tumors in tumor-bearing nude mice: increased granulocyte and macrophage progenitors in murine bone marrow. (1995) (27)
Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes (2020) (26)
Gemcitabine induces cell senescence in human pancreatic cancer cell lines. (2016) (26)
Eotaxin contributes to renal interstitial eosinophilia. (1999) (25)
Protective Roles of Interferon‐γ in Cardiac Hypertrophy Induced by Sustained Pressure Overload (2018) (25)
IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation. (2007) (25)
Involvement of Prokineticin 2–expressing Neutrophil Infiltration in 5-Fluorouracil–induced Aggravation of Breast Cancer Metastasis to Lung (2018) (25)
Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages (2008) (25)
Spontaneous production of interleukin-8 by human lung cancer cells and its augmentation by tumor necrosis factor alpha and interleukin-1 at protein and mRNA levels. (1994) (24)
IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids. (2005) (24)
Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein‐1 delivery in mice (2010) (24)
Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma (2018) (24)
Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression. (2014) (23)
CCR1 chemokine receptor expression isolates erythroid from granulocyte‐macrophage progenitors (2001) (23)
Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: Involvement of monocyte-derived interleukin-1-alpha (1998) (22)
Potential involvement of monocyte chemoattractant protein (MCP)-1/CCL2 in IL-4-mediated tumor immunity through inducing dendritic cell migration into the draining lymph nodes. (2003) (22)
Role of C‐C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein‐1α in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production (2004) (22)
Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites. (1998) (22)
Proinflammatory cytokines interleukin 1 and tumor necrosis factor induce cytokines that are chemotactic for neutrophils, T cells and monocytes. (1990) (22)
Contribution of the TNF-&agr; (Tumor Necrosis Factor-&agr;)–TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus (2018) (22)
Impairment of Endotoxin-Induced Macrophage Inflammatory Protein 2 Gene Expression in Alveolar Macrophages in Streptozotocin-Induced Diabetes in Mice (2000) (21)
Resveratrol stimulation induces interleukin‐8 gene transcription via NF‐&kgr;B (2018) (21)
Novel Process of Intrathymic Tumor-Immune Tolerance through CCR2-Mediated Recruitment of Sirpα+ Dendritic Cells: A Murine Model (2012) (21)
Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis (2020) (20)
Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice. (2000) (20)
Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7: role of kappaB-3 binding protein. (2000) (20)
Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells (2014) (20)
hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin (2004) (20)
Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization. (2015) (20)
The Frequency of Type 2 CD8+ T Cells Is Increased in Peripheral Blood from Patients with Psoriasis Vulgaris (2003) (20)
Interleukin‐8 inhalation directly provokes bronchoconstriction in guinea pigs (1999) (20)
A specific elevation of RANTES in bronchoalveolar lavage fluids of patients with chronic eosinophilic pneumonia. (1997) (19)
Signal requirement for interleukin-1-dependent interleukin 2 production by a human leukemia-derived HSB.2 subclone. (1987) (19)
Induction of dendritic cell differentiation by granulocyte-macrophage colony-stimulating factor, stem cell factor, and tumor necrosis factor alpha in vitro from lineage phenotypes-negative c-kit+ murine hematopoietic progenitor cells. (1997) (19)
Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells. (2009) (19)
Identification of an IκBα-associated Protein Kinase in a Human Monocytic Cell Line and Determination of Its Phosphorylation Sites on IκBα (*) (1995) (18)
C-C chemokine ligand 3 deficiency ameliorates diet-induced Steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice. (2021) (18)
Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis‐inducing ability (2010) (18)
In Vitro Effects of Immunosuppressive Agents on Cytokine Production by HTLV‐I‐Infected T Cell Clones Derived from the Ocular Fluid of Patients with HTLV‐I Uveitis (1996) (18)
Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells. (2007) (18)
Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2 tumor-associated macrophages in skin carcinogenesis. (2020) (17)
Ag and IL‐2 immune complexes efficiently expand Ag‐specific Treg cells that migrate in response to chemokines and reduce localized immune responses (2014) (17)
Macrophages as producers of chemotactic proinflammatory cytokines. (1994) (17)
Signal transducer and activator of transcription 3 upregulates interleukin‐8 expression at the level of transcription in human melanoma cells (2009) (17)
PPARα activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells (2004) (17)
Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells (2018) (17)
A novel leukocyte chemotactic and activating cytokine, interleukin-8 (IL-8). (1995) (17)
Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury (2012) (16)
Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity (2012) (16)
Monocyte chemoattractant protein‐1 gene modification of multidrug‐resistant human lung cancer enhances antimetastatic effect of therapy with anti‐P‐glycoprotein antibody in SCID mice (1999) (16)
The participation of IL-8 in the synovial lesions at an early stage of rheumatoid arthritis. (1999) (16)
Publisher Correction: Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra (2020) (16)
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma (2003) (15)
Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process (2020) (15)
Effects of anti-Tac antibody on the response of large granular lymphocytes to interleukin-2. (1986) (15)
NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor (2001) (14)
Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation. (2005) (14)
CX3CL1-CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice. (2021) (14)
Intestinal microbiota: unexpected alliance with tumor therapy. (2014) (14)
Production of IL-8 and the other cytokines by T cell clones established from the ocular fluid of patients with Behçet's disease. (1995) (14)
IFN-Inducible Protein 10 (CXCL10) Regulates Tubular Cell Proliferation in Renal Ischemia-Reperfusion Injury (2008) (13)
Intervention in endotoxin shock by sulfatide (I3SO3-GalCer) with a concomitant reduction in tumor necrosis factor alpha production (1997) (13)
Participation of endogenously produced interferon gamma in interleukin 4-mediated tumor rejection. (2000) (12)
Stimulation of transient receptor potential M3 (TRPM3) channels increases interleukin‐8 gene promoter activity involving AP‐1 and extracellular signal‐regulated protein kinase (2017) (12)
[Antibody-dependent cell-mediated cytotoxicity]. (1997) (12)
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma (2003) (12)
Regulation of placental monocyte chemotactic and activating factor during pregnancy and chorioamnionitis. (1998) (12)
Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines. (1998) (12)
Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha. (1998) (11)
Retraction: Essential Role of Transcription Factor Nuclear Factor-κB in Regulation of Interleukin-8 Gene Expression by Nitrite Reductase from Pseudomonas aeruginosa in Respiratory Epithelial Cells (2011) (11)
MCAF/MCP-1 protein expression in a rat model for pulmonary hypertension induced by monocrotaline. (1998) (11)
Implication of “Down syndrome cell adhesion molecule” in the hippocampal neurogenesis of ischemic monkeys (2006) (11)
Augmented expression of tumour necrosis factor‐α induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein‐1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages (2002) (11)
Establishment and characterization of a human malignant fibrous histiocytoma cell line. (1995) (11)
The role of protein kinase C activation in signal transmission by interleukin 2. (1988) (10)
Effect of thromboxane A2 antagonists on bronchial hyperresponsiveness induced immediately after interleukin‐8 inhalation in guinea‐pigs (1997) (10)
Wound-Healing Process in the Skin b and TGF- g between IFN-The Essential Involvement of Cross-Talk (2004) (10)
Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer (2011) (10)
Establishment of essential involvement of IL-8 in acute inflammation (1994) (10)
Chemokines in the bronchoalveolar lavage fluid of patients with sarcoidosis. (1997) (10)
High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites. (2015) (10)
IL (Interleukin)-1a Promotes Nuclear Factor-kB and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas (2001) (10)
Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma (2012) (9)
Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. (2011) (9)
Specific increase in interleukin-8 concentrations in dialysis fluid of patients with peritonitis receiving continuous ambulatory peritoneal dialysis. (1995) (8)
MIP-1 / CCL 3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia (2013) (8)
Establishment of a highly sensitive enzyme-linked immunosorbent assay for interleukin-1 alpha employing a fluorogenic substrate. (1988) (8)
Splicing inhibition induces gene expression through canonical NF‐κB pathway and extracellular signal‐related kinase activation (2014) (8)
Interleukin 2-dependent T cell line acquires responsiveness to phorbol myristate acetate and lipopolysaccharide in the course of long-term culture. (1984) (8)
CHAPTER 46 – Interleukin-8 and other CXC chemokines (2003) (8)
[The roles of cytokine receptors in diseases]. (2000) (8)
Protective Roles of the Fractalkine/CX3CL1‐CX3CR1 Axis against Alkali‐induced Corneal Neovascularization thorough Enhanced Anti‐angiogenic Factor Expression (2008) (7)
Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse. (2000) (7)
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice (2018) (7)
Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer (2019) (7)
CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations (2013) (7)
PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells. (2004) (7)
[Inflammation and pro-inflammatory cytokine]. (1992) (7)
Human cytomegalovirus replication supported by virus-induced activation of CCL2-CCR2 interactions. (2014) (6)
IL-1-induced production of IL-2 and IFN-gamma in subclones of human T-cell derived leukaemia HSB.2 cells: regulation by phytohaemagglutinin-mediated (poly)phosphoinositide breakdown and cyclic AMP. (1990) (6)
Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone (2020) (6)
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation (2021) (6)
A radioimmunoassay that sandwiches human interleukin-2 between radiolabeled monoclonal antibody and the receptor on a hematopoietic cell line. (1986) (6)
Molecular mechanism of interleukin-8 gene expression. (1993) (5)
Efficient generation of highly immunocompetent dendritic cells from peripheral blood of patients with hepatitis C virus-related hepatocellular carcinoma. (2014) (5)
Interleukin-1 receptor antagonist mediates type I interferon-driven susceptibility to Mycobacterium tuberculosis (2018) (5)
[Antibody-dependent cell-mediated cytotoxicity (ADCC)]. (1997) (5)
Appearance of interleukin-8 in the urine predicts acute rejection of renal transplantation. (1994) (5)
Interleukin 1 Regulation of Interleukin 2 and Interferon‐γ Gene Activation in a Human Leukemic HSB.2 Subclone (1989) (4)
CCR5 gene expression in fulminant hepatitis and DTH in mice. (1998) (4)
Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression (2017) (4)
Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia (2021) (4)
Discrepancy between the production of interleukin 1, alpha-interferon and granulocytic colony-stimulating activity of human monocytes stimulated by a partially purified human urinary colony-stimulating factor. (1986) (4)
Response Element Binding Protein , and NF-Activating Transcription Factor-2 , cAMP Reveals a Prominent Role for p 38 MAPK in VacA Induction of IL-8 in U 937 Cells pylori Helicobacter (2008) (4)
Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway (2021) (4)
Tolerance against Blood-Borne Antigens in a Conventional Dendritic Cells to Central + α Crucial Contribution of Thymic Sirp (2009) (4)
The role of a chemokine receptor, CCR2, in suppressing the development of arthritis in IL-1 receptor antagonist-deficient mice (2012) (4)
Tumor Necrosis Factor ( TNF ) Is a Physiologic Regulator of Hematopoietic Progenitor Cells : Increase of Early Hematopoietic Progenitor Cells in TNF Receptor p 55-Deficient Mice In Vivo and Potent Inhibition of Progenitor Cell Proliferation by TNFa In Vitro (2002) (4)
Interleukin 8 and its Receptor (1998) (4)
Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent. (2015) (3)
CCR5 antagonist, an ally to fight against metastatic colorectal cancer (2016) (3)
CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status. (2022) (3)
Regulation of stimulus-induced interleukin-8 gene transcription in human adrenocortical carcinoma cells - Role of AP-1 and NF-κB. (2020) (3)
The biological, biochemical, and molecular profile of leukocyte chemotactic and activating cytokine, interleukin-8 (1997) (3)
[A newly discovered chemotactic factor for neutrophil: interleukin 8]. (1992) (3)
Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis. (2020) (3)
[The role of monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein (MCP)-1 in subgroups of rapidly progressive glomerulonephritis]. (1999) (2)
DSCAM in the hippocampal neurogenesis of ischemic monkeys (2007) (2)
Reduced Serum Antibody Production and Acute Airway Inflammation in Interleukin 6-deficient Mice Challenged with Ovalbumin (2005) (2)
This information is current as in Acute Bacterial Pneumonia Ligand-2 to Resolution and Repair Processes Chemoattractant Protein-1/C-C Chemokine Essential Contribution of Monocyte (2013) (2)
Title High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP 1 / CD 107 a-expressing CD 4-positive T cells into tumor sites (2017) (2)
biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-icB and regulation of cytokine production/action through 132 integrin in vivo (1996) (2)
IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. (2019) (2)
Expression through Enhanced Antiangiogenic Factor in Alkali-Induced Corneal Neovascularization Fractalkine / CX 3 CL 1-CX 3 CR 1 Interactions Protective (2008) (2)
[MMP-9 expression profile in inflammatory cells of Mip-1alpha knockout mice and Mip-1alpha receptor knockout mice]. (2009) (2)
peripheral blood leukocytes and mature myeloid lineage cells in bone marrow (1996) (2)
Establishment of a sensitive radioimmunoassay for serum thymic factor with a special reference to extraction procedures (1992) (2)
肺疾患におけるインターロイキン‐8/CXCL8の病態生理学的役割 (2003) (2)
Correction: mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells (2011) (1)
Retraction. Essential role of transcription factor nuclear factor-κB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aeruginosa in respiratory epithelial cells. (2011) (1)
Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis andTumorigenesis of Gastric Carcinoma in NudeMice viaMacrophage Recruitment (2005) (1)
Cytokine regulation in diseases (PP-090) (2010) (1)
Differentiation-inducing factor for a human leukemic cell line produced by colony-stimulating factor producing human lung cancer tissue. (1987) (1)
[Antibody-dependent cell-mediated cytotoxicity (ADCC)]. (1997) (1)
Crucial Involvement of the CCR2/CCL2 Interactions in Azoxymethane/Dextran Sodium Sulfate-induced Colon Carcinogenesis in Mice (2009) (1)
Increased NF-kB and AP-1 activity and increased stability of IL-8 transcripts underlie IL-8 mRNA superinduction in airway epithelial H292 cells☆ (1997) (1)
Septic Peritonitis Signals in the Bactericidal Host Defense Essential Involvement of CX 3 CR 1-Mediated (2008) (1)
Interleukin-8 and MCAF: Novel Leukocyte Recruitment and Activating Cytokines (Part 2 of 2) (1992) (1)
An Interleukin-1/Tumor Necrosis Factor Inducible Inflammatory Cytokine, Interleukin-8 (1990) (1)
Prevention of endotoxin shock through targeting leukocyte adhesion molecules. (1998) (1)
Crosstalk between Cancer Cells and Fibroblasts for the Production of Monocyte Chemoattractant Protein-1 in the Murine 4T1 Breast Cancer (2021) (1)
Identification of an I (cid:107) B (cid:97) -associated Protein Kinase in a Human Monocytic Cell Line and Determination of Its Phosphorylation Sites on I (cid:107) B (cid:97) * (1995) (1)
P-3-297 The role of interleukin-8 in cerebral isehemla-reperfusion injury (1997) (1)
CCR2- and CCR5-mediated macrophage infiltration contributes to glomerular endocapillary hypercellularity in antibody-induced lupus nephritis. (2021) (1)
The roles of IL-1 receptor antagonist in skin wound healing (2008) (1)
Retraction: Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells (2011) (1)
CCL5–CCR5 axis mediates skin wound healing by promoting endothelial progenitor cell accumulation (2009) (1)
ID: 33: CCL4 can promote bone metastasis of a murine breast cancer cell line, by interacting CCR5-expressing non-tumor cells in bone marrow (2015) (1)
[Analysis of lymphocyte subsets]. (1985) (0)
[Artifactual interaction of PMA (phorbol myristate acetate) in the determination of interleuken 2 (IL 2) activity]. (1984) (0)
Title Ablation of the Ccr 2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice (2017) (0)
Development of chemokine gene therapy against tumors (2003) (0)
Title Pathophysiological roles of Pim-3 kinase in pancreatic cancer developmentand progression (2017) (0)
Cytokine receptors and signaling (PP-089) (2010) (0)
P163 Crucial involvement of the CCL3-CCR5 axis in fibrosis accompanied with mouse chronic colitis-associated carcinogenesis (2012) (0)
Research highlights. (2011) (0)
Molecular Mechanism of hepatoma development in Hepatitis B surface antigen (HBs) transgenic (Tg) mice (2003) (0)
- 1-Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells (2017) (0)
P167 Essential role of CX3CR1 in bleomycin-induced pulmonary fibrosis through regulation of bone marrow-derived fibocyte infiltration (2012) (0)
PRIMARY IMMUNODEFICIENCY DISEASES (1995) (0)
Establishment of central tolerance against blood-borne antigens by thymic Sirp{alpha}+ conventional dendritic cells (2010) (0)
Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2-TAMs in skin carcinogenesis (2019) (0)
[The measurement of interleukin 1 (IL 1) and interleukin 2 (IL 2) employing the MTT assay]. (1985) (0)
P038 A role of IFN-gamma in pressure overload-induced compensatory cardiac hypertrophy (2012) (0)
Chemokines iin b bronchoalveolar llavage ffluid in s summer-type h hypersensitivity p pneumonitis (1995) (0)
330 Prevention of azoxymemethane/dextran sodium sulfate-induced colon carcinogenesis by CCR2 blockade (2008) (0)
Associated with Th 2 Cytokine Production Impaired Dendritic Cell Maturation withIL-1 Receptor Antagonist-Deficient Mice Exacerbation of Granuloma Formation in Nakashima and Kouji (2005) (0)
IFN-γ Mini Review Clostridium difficile toxin A 誘発腸炎における (2005) (0)
Mechanisms of Interleukin-8 Gene Regulation by Tumor Necrosis Factor and Interleukin-1 (1992) (0)
Prevention of Intrahepatic Metastasis of Liver Cancer by Suicide Gene Therapy and CCL2/MCP-1 Delivery in Mice (2011) (0)
Pivotal involvement of IFN-gamma/Stat5 axis in compensatory cardiac hypertrophy induced by pressure overload (2013) (0)
[Immunologic tests: Antibody-dependent cell-mediated cytotoxicity (ADCC)]. (2005) (0)
InfiltrationOvarian Cancer In Vivo Due to Neutrophil IL-8 Reduced Tumorigenicity of Human (2000) (0)
Crucial involvement of tumor necrosis factor in colon carcinogenesis (2009) (0)
κ Pancreatitis by Repressing NF- Protects Cerulein-Induced Acute γ IFN- (2017) (0)
The absence of CX3CR1 impairs inflammation-induced preterm labor through the reduction of macrophage recruitment (2016) (0)
Alleviation of Lipopolysaccharide-Induced Acute Liver Injury in Propionibacterium acnes-Primed IFN-γ-Deficient Mice by a Concomitant Reduction of TNF-α, IL-12, and IL-18 Production (1999) (0)
Inflammatory bowel diseases (PP-065) (2010) (0)
Cancer Therapy : Preclinical Met Kinase Inhibitor E 7050 Reverses Three Different MechanismsofHepatocyteGrowth Factor – Induced Tyrosine Kinase Inhibitor Resistance in EGFR Mutant Lung Cancer (2012) (0)
105 Reversal of Chronic Colitis-Associated Colon Carcinoma Progression by Tumor Necrosis Factor Blockade (2007) (0)
Specific increase ininterleukin-8 concentrations indialysis fluid ofpatients withperitonitis receiving continuous ambulatory peritoneal dialysis (1995) (0)
Development of a novel type of anti-inflammatory agents, targeting chemokines (1996) (0)
Progressive Biliary Destruction is Independent of a Functional Tumor Necrosis Factor-alpha Pathway in a Murine Model of Biliary Atresia 1 (2007) (0)
PS1-063 Absence of IFN-gamma accelerates thrombus resolution through enhanced MMP-9 and VEGF expression (2011) (0)
Tumor Immunotherapy by Utilizing a Double-Edged Sword, Chemokines (2013) (0)
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocarcinogenesis (2006) (0)
[Cytokine network involved in inflammatory reactions]. (1997) (0)
PS2-030. Ablation of CC chemokine receptor 2 gene exacerbates the polyarthritis in interleukin-1 receptor antagonist-deficient mice (2011) (0)
DB111506 1680..1690 (2012) (0)
CANCER GENE THERAPY USING CYTOKINE AND CHEMOKINE GENES (2004) (0)
494 LPA6 promotes growth and tumorigenicity of hepatocellular carcinoma via activation of PIM-3 proto-oncogene kinase (2014) (0)
Title Essential contribution of a chemokine , CCL 3 , and its receptor , CCR 1 , tohepatocellular carcinoma progression (2017) (0)
Growth inhibition of Plasmodium falciparum and interleukin-8 production by peripheral blood mononuclear and polymorphonuclear cells in vitro. (2002) (0)
77 Pivotal Roles of CX3CL1–CX3CR1 Axis in the Innate Immune Responses During Septic Peritonitis (2007) (0)
Title CCL 2 / CCR 2 augments the production of transforming growth factor-beta 1 , type 1 collagen and CCL 2 by human CD 45-/ collagen 1-positive cells under high glucose concentrations (2017) (0)
Essential role of chemokine receptor CX3CR1 in bleomycin‐induced pulmonary fibrosis through regulation of bone marrow‐derived fibocyte infiltration (2011) (0)
Essential contribution of tumor necrosis factor receptor (TNF-R) p55-mediated signals in metastasis and carcinogenesis (2006) (0)
138: Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in murine deep vein thrombosis model (2014) (0)
Erratum to 'Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression' [Antiviral Research (2017) 15-19]. (2018) (0)
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice (2023) (0)
Enhancement ofHumanCytomegalovirus Replication ina HumanLungFibroblast CellLinebyInterleukin-8 (1994) (0)
P179 Antigen-specific regulation of immune reaction by systemically expanded Tregs against blood-borne antigen (2012) (0)
Immune Mechanisms of Pulmonary Fibrosis with Bleomycin (2023) (0)
A Case of Traumatic High Thoracic Myelopathy Presenting Dissociated Impairment of Rostral Sympathetic Innervations and Isolated Segmental Sweating on Otherwise Anhidrotic Trunk (1999) (0)
Establishment of central tolerance against blood-borne antigens by thymic Sirpα+ conventional dendritic cells (98.5) (2010) (0)
inhibition of progenitor cell proliferation by TNF alpha in vitro progenitor cells in TNF receptor p55-deficient mice in vivo and potent hematopoietic progenitor cells: increase of early hematopoietic Tumor necrosis factor (TNF) is a physiologic regulator of (2011) (0)
[Mechanism of the production and the action of IL-1]. (1991) (0)
Title: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines (2004) (0)
[Percentage of T cells bearing receptors for IgG or IgM Fc portion]. (1999) (0)
[Percentage of T cells bearing receptors for IgG or IgM Fc portion]. (1999) (0)
Expression in Mononuclear Cells B Activation Is Required for C5a-Induced Interleukin-8 Gene κ NF- (2013) (0)
Title Identification of a phenanthrene derivative as a potent anticancer drug withPim kinase inhibitory activity (2017) (0)
Abstract 1541: NK cells are indispensable for suppression of tumor growth and metastasis in transgenic mice overexpressing chemokine CXCL14/BRAK (2012) (0)
Molecular mechanism of acute and chronic liver injuries (2003) (0)
[Studies on immunoglobulin production by human lymphocytes. I. Latex fixation test for determination of immunoglobulins in the supernatant fluid of lymphocyte culture (author's transl)]. (1981) (0)
in tumor-bearing mice Chemokine-mediated rapid turnover of myeloid-derived suppressor cells (2013) (0)
Prevention of endotoxin shock by an antibody against leukocyte integrin β2 (CD18) (1994) (0)
Chemokine, as a target to intervene inflammation. (1997) (0)
Expression the Induction of Heme Oxygenase-1 throughSignals in Toxin A-Induced Enteritis Protective Roles of CX 3 CR 1-Mediated (2010) (0)
2016 Colorectal Cancer: Global view Fibroblasts, an inconspicuous but essential player in colon cancer development and progression in colon carcinogenesis (2016) (0)
Human Ovarian Carcinoma Cells Hypoxia-induced Elevation in Interleukin-8 Expression by Updated Version (1999) (0)
Essential contribution of the CCL3-CCR5 axis to murine lung metastasis process (2009) (0)
Rheumatoid arthritis and other inflammatory joint diseases (animal models) (PP-037) (2010) (0)
Response Inhibition of the Interferon-Induced Antiviral Induces Interleukin-8 , Leading to Partial Hepatitis C Virus Nonstructural 5 A Protein (2001) (0)
[Stimulation of lymphocytes from patients with primary immunologic disease using Staphylococcus aureus Cowan I strain]. (1981) (0)
Essential involvement of a chemokine receptor, CCR2, to liver metastasis (2006) (0)
C-XC Chemokine ( s ) Neutrophil Migration into Vagina in Mice by a Physiologic Regulation of Postovulatory (1998) (0)
129 CC Chemokine receptor 5-dependent endothelial progenitor cell homing to skin wound (2008) (0)
B Activation κ Pancreatitis by Repressing NF-Protects Cerulein-Induced Acute γ IFN-Iwakura , Naofumi Mukaida and Toshikazu (2007) (0)
Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice 1 (2000) (0)
Title Essential contribution of Ets-1 to constitutive Pim-3 expression in humanpancreatic cancer cells (2017) (0)
[Percentage of T cells bearing receptors for IgG or IgM Fc portion]. (2010) (0)
140 Protective role of CX3CR1-medicated signal pathway in Clostridium difficile toxin A-induced enteritis (2008) (0)
[Quantitative measurement of rheumatoid factor (RF) by turbidimetric immunoassay (TIA)--methodological and clinical investigations]. (1987) (0)
Title Intestinal microbiota : Unexpected alliance with tumor therapy (2017) (0)
Enhanced expression of a proto-oncogene, Pim-3, with serine/threonine kinase activity, in various types of tumors (2006) (0)
Symposium7:Network of Cytokines and Adhesion Molecules Cytokine Network Involved in Inflammatory Reactions (1997) (0)
Acknowledgement of Reviewers 2011 (2012) (0)
ID: 91: Absence of CCR5 exaggerated pressure overload-induced heart failure in mice (2015) (0)
Abstract 424: Chemokine CXCL14 is a multistep tumor suppressor (2015) (0)
Effects of recombinant IL 2 & IFNγ on natural killer cell activity of peripheral blood lymphocytes from normal donors and cancer patients (1984) (0)
Inflammatory and fibrotic lung diseases (WS-085) Chairpersons: Toshihiro Nukiwa, Thomas Wynn (2010) (0)
139 The absence of IL-6/STAT3 signals enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant ERK activation (2008) (0)
Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration (2017) (0)
Novel Mediators for Chronic Inflammation and Oncogenic Transformation: Tumor Necrosis Factor (TNF)-α (2012) (0)
J 12,14 12,14 D Expression by 15-Deoxy-Differential Regulation of Chemokine Gene (2001) (0)
Molecular mechanism of liver metastasis (2003) (0)
[Chemokines in chronic myeloid leukemia]. (2016) (0)
[Effects of various physiological factors on the quantitative determination of serum rheumatoid factor]. (1987) (0)
Activator Protein-2 B and k Transcriptionally Regulated by NF--3-Oxododecanoyl Homoserine Lactone Is N Autoinducer Pseudomonas and Epithelial Cells Activated by the IL-8 Production in Human Lung Fibroblasts (2001) (0)
Hepatocellular Carcinoma with Monocyte Chemoattractant Protein-1 Effects of Suicide Gene Therapy Combined Prolonged , NK Cell-Mediated Antitumor (2006) (0)
Tumor cells transfected with immunosuppressive cytokine gene augmented tumorigenicity in vivo (1994) (0)
PS2-059. Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis (2011) (0)
Thymic selection (WS-032) Chairpersons: Taishin Akiyama, Ed Palmer (2010) (0)

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