Naoyuki Kamatani

Q: What Schools Are Affiliated With Naoyuki Kamatani

Naoyuki Kamatani is affiliated with the following schools: University of Tokyo, Riken, Tokyo Women's Medical University, Osaka University

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Naoyuki Kamatani

Philosophy

#6641

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#9706

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#3776

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#4984

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philosophy Degrees

Naoyuki Kamatani

Biology

#8992

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#12143

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Immunology

#526

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#543

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biology Degrees

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Philosophy
Biology

Naoyuki Kamatani's Degrees

PhD Immunology University of Tokyo
Doctorate Medicine University of Tokyo

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Naoyuki Kamatani's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. (1999) (1734)
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators (2012) (777)
Role of TBX1 in human del22q11.2 syndrome (2003) (761)
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus (2008) (739)
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations (2008) (717)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations (2012) (678)
Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction (2006) (568)
Meta-analysis identifies six new susceptibility loci for atrial fibrillation (2012) (535)
Genome-wide association study of hematological and biochemical traits in a Japanese population (2010) (506)
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians (2009) (487)
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. (2011) (469)
Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. (2001) (445)
New gene functions in megakaryopoiesis and platelet formation (2011) (423)
A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. (2004) (403)
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas (2011) (388)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
Meta-analysis identifies common variants associated with body mass index in East Asians (2012) (372)
Comparison of Disease Activity Score (DAS)28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values (2006) (368)
Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis (2007) (368)
Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. (2008) (350)
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma (2011) (338)
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population (2011) (319)
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population (2012) (299)
Association of a novel long non‐coding RNA in 8q24 with prostate cancer susceptibility (2011) (295)
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population (2010) (293)
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. (2002) (274)
Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits (2011) (271)
A genome-wide association study identifies three new risk loci for Kawasaki disease (2012) (268)
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (2009) (265)
Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations (2012) (264)
UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecan‐administered Japanese Patients with Cancer (2004) (262)
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B (2010) (261)
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility (2010) (254)
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population (2009) (251)
Variations in the FTO gene are associated with severe obesity in the Japanese (2008) (247)
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations (2012) (226)
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis (2013) (218)
A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis (2011) (218)
Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. (2000) (217)
Identification of the gene loci that predispose to rheumatoid arthritis. (1998) (215)
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (2011) (206)
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis (2008) (206)
IL‐17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti‐TNF‐α antibody: A novel mechanism of osteoclastogenesis by IL‐17 (2009) (198)
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. (2008) (192)
Excessive Production of IFN-γ in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B1 (2008) (192)
Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis. (2003) (180)
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. (2006) (180)
A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E (2009) (177)
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations (2010) (168)
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012) (167)
Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. (2008) (165)
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011) (163)
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population (2010) (161)
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population (2004) (159)
Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population (2011) (154)
The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis. (2002) (154)
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese (2010) (154)
Association between PADI4 and rheumatoid arthritis: a replication study. (2005) (152)
Genome-wide association study identifies three novel loci for type 2 diabetes. (2014) (149)
Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients (2006) (148)
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population (2011) (146)
Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease. (2001) (146)
Increased CD40 Expression on Muscle Cells of Polymyositis and Dermatomyositis: Role of CD40-CD40 Ligand Interaction in IL-6, IL-8, IL-15, and Monocyte Chemoattractant Protein-1 Production1 (2000) (145)
IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats (2007) (144)
Association of functional polymorphisms of matrix metalloproteinase (MMP)‐1 and MMP‐3 genes with colorectal cancer (2002) (139)
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers (2005) (138)
Genome-Wide Association Study of Pancreatic Cancer in Japanese Population (2010) (137)
Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme. (1981) (134)
Pulmonary hypertension in systemic lupus erythematosus: evaluation of clinical characteristics and response to immunosuppressive treatment. (2002) (133)
The molecular mechanism of osteoclastogenesis in rheumatoid arthritis (2002) (131)
IFN‐γ‐producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL (2005) (131)
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. (2005) (131)
Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. (1997) (127)
Association between PADI4 and rheumatoid arthritis: a meta-analysis. (2006) (126)
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. (2010) (125)
Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population. (2006) (124)
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. (2013) (124)
Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA (2010) (124)
Multiple Loci Are Associated with White Blood Cell Phenotypes (2011) (123)
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population (2009) (123)
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population (2012) (122)
Association between adult-onset Still's disease and interleukin-18 gene polymorphisms (2002) (121)
IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C. (2011) (120)
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (2010) (119)
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (2012) (117)
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids (2011) (116)
Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis. (2005) (116)
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for human leukocyte antigen B (HLA‐B) genotype and allopurinol dosing: 2015 update (2016) (114)
New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study (2010) (114)
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population (2008) (114)
Case–control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population (2009) (113)
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese (2012) (112)
Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis (2012) (110)
Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. (2004) (109)
Meta‐analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis (2011) (108)
Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture. (1987) (108)
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese (2012) (107)
Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment. (1998) (104)
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (2012) (103)
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy (2010) (101)
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. (2003) (99)
Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines. (1980) (98)
Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir (2011) (98)
A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population (2006) (96)
Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts. (1981) (94)
KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases. (2000) (94)
Targeted Exon Sequencing Successfully Discovers Rare Causative Genes and Clarifies the Molecular Epidemiology of Japanese Deafness Patients (2013) (92)
Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice (2007) (91)
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. (2011) (90)
Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study. (2008) (90)
Meta-analysis of association between the ASPN D-repeat and osteoarthritis. (2007) (90)
Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs. (2004) (89)
Identification of a membrane glycoprotein overexpressed in murine lymphoma sublines resistant to cis-diamminedichloroplatinum(II). (1990) (87)
Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy (2007) (86)
Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm (2002) (85)
Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis. (2001) (85)
What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity. (2007) (84)
Molecular aspects of rheumatoid arthritis: role of transcription factors (2008) (84)
Increased risk of tuberculosis in patients with rheumatoid arthritis in Japan (2006) (83)
Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma (2012) (83)
Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis (2005) (81)
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan (2003) (81)
Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population (2011) (80)
Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis (1999) (79)
Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese (2008) (78)
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma (2009) (77)
Genetic variations and haplotypes of CYP2C19 in a Japanese population. (2005) (77)
Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene. (2002) (76)
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association (2009) (76)
Haplotype structures of the UGT1A gene complex in a Japanese population (2006) (76)
Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese (2006) (76)
Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. (2005) (76)
Improvement of disease activity of rheumatoid arthritis patients from 2000 to 2006 in a large observational cohort study IORRA in Japan (2007) (74)
Association of cryptorchidism with a specific haplotype of the estrogen receptor alpha gene: implication for the susceptibility to estrogenic environmental endocrine disruptors. (2005) (74)
Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population (2003) (74)
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus (2005) (72)
Molecular targets of rheumatoid arthritis. (2008) (72)
Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack (2008) (72)
Association of IL1A gene polymorphisms with susceptibility to and severity of systemic sclerosis in the Japanese population. (2003) (72)
Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. (2007) (72)
Control of renal uric acid excretion and gout (2008) (70)
Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. (1982) (69)
Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics (2012) (68)
Increased IL-15 production of muscle cells in polymyositis and dermatomyositis. (2002) (68)
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (2014) (68)
Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP (2019) (67)
Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout (2009) (67)
Trends in the manifestations of gout in Taiwan. (2003) (66)
A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout. (2005) (65)
Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin. (2007) (65)
Familial juvenile hyperuricemic nephropathy: detection of mutations in the uromodulin gene in five Japanese families. (2004) (64)
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn’s disease in Japanese patients (2008) (63)
Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects. (2003) (63)
The Influence of Sex on Patients with Rheumatoid Arthritis in a Large Observational Cohort (2009) (63)
Intracellular IL-1α-binding proteins contribute to biological functions of endogenous IL-1α in systemic sclerosis fibroblasts (2006) (62)
Estimation of haplotype frequencies, linkage-disequilibrium measures, and combination of haplotype copies in each pool by use of pooled DNA data. (2003) (62)
Association Study of 71 European Crohn's Disease Susceptibility Loci in a Japanese Population (2013) (61)
A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1 (2012) (61)
Efficient management of rheumatoid arthritis significantly reduces long-term functional disability (2007) (61)
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. (2013) (61)
Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family. (2000) (61)
Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. (2008) (61)
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. (2013) (60)
A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population (2006) (60)
Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. (2010) (60)
Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities. (2007) (60)
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. (2011) (60)
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression (2012) (60)
Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip. (2007) (59)
Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus (2006) (58)
Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells. (2001) (57)
A novel single-nucleotide polymorphism at the 5'-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. (2001) (57)
Genetic variations and haplotypes of UGT1A4 in a Japanese population. (2005) (56)
Evaluation of Pneumocystis pneumonia infection risk factors in patients with connective tissue disease (2006) (55)
Prediction model for knee osteoarthritis based on genetic and clinical information (2010) (55)
A prospective study of renal disease in patients with early rheumatoid arthritis (2001) (55)
Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo. (1982) (55)
Human adenine phosphoribosyltransferase deficiency. Demonstration of a single mutant allele common to the Japanese. (1988) (55)
An Allopurinol-Controlled, Randomized, Double-Dummy, Double-Blind, Parallel Between-Group, Comparative Study of Febuxostat (TMX-67), a Non-Purine-Selective Inhibitor of Xanthine Oxidase, in Patients With Hyperuricemia Including Those With Gout in Japan: Phase 3 Clinical Study (2011) (54)
Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production (2006) (54)
Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences (2007) (54)
Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide. (2007) (54)
Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40‐CD154 in the phenotype of SSc fibroblasts (2003) (54)
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. (2011) (54)
NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity (2006) (53)
Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis. (2003) (53)
Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese (2012) (53)
Association of a haplotype in the serotonin 5‐HT4 receptor gene (HTR4) with Japanese schizophrenia (2003) (52)
Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1α and its transcription activity (2007) (52)
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (2010) (52)
Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupus. (2004) (52)
Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis (2007) (52)
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients (2005) (52)
Pharmacogenomics and Patient Care: One Size Does Not Fit All (2012) (51)
Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. (2004) (51)
A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. (2011) (51)
Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics (2012) (51)
Severe impairment in adenine metabolism with a partial deficiency of adenine phosphoribosyltransferase. (1985) (50)
Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. (2007) (50)
Impact of shoulder, elbow, and knee joint involvement on assessment of rheumatoid arthritis using the American College of Rheumatology Core Data Set. (2005) (50)
Association between GLUT9 and gout in Japanese men (2010) (50)
Only three mutations account for almost all defective alleles causing adenine phosphoribosyltransferase deficiency in Japanese patients. (1992) (50)
Accelerated purine nucleotide degradation by anaerobic but not by aerobic ergometer muscle exercise. (1992) (49)
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese (2008) (49)
Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement. (2007) (48)
Molecular aspects of rheumatoid arthritis: role of environmental factors (2008) (48)
Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy. (2004) (48)
Common genetic polymorphism of ITPA gene affects ribavirin‐induced anemia and effect of peg‐interferon plus ribavirin therapy (2011) (48)
Anti‐arthritis effects of vitamin K2 (menaquinone‐4) − a new potential therapeutic strategy for rheumatoid arthritis (2007) (47)
Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. (2013) (47)
Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population (2012) (47)
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. (2017) (46)
Disability and patient’s appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan (2006) (46)
Influence of methotrexate dose on its efficacy and safety in rheumatoid arthritis patients: evidence based on the variety of prescribing approaches among practicing Japanese rheumatologists in a single institute-based large observational cohort (IORRA) (2007) (46)
Trans-ethnic meta-analysis of white blood cell phenotypes. (2014) (46)
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population. (2006) (45)
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations (2018) (45)
Elevation of serum matrix metalloproteinase-3 as a predictive marker for the long-term disability of rheumatoid arthritis patients in a prospective observational cohort IORRA (2007) (45)
Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. (2007) (45)
Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis. (2006) (44)
Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride (2016) (44)
Serum nitric oxide (NO) levels in systemic sclerosis patients: correlation between NO levels and clinical features (2003) (43)
Alkaline Phosphatase in Rheumatoid Arthritis Patients: Possible Contribution of Bone-Type ALP to the Raised Activities of ALP in Rheumatoid Arthritis Patients (2002) (43)
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population (2010) (42)
A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. (2010) (42)
Genetic and clinical studies on 19 families with adenine phosphoribosyltransferase deficiencies (1987) (42)
High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references (2015) (42)
A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (2009) (42)
Association of HLA class I and class II alleles with myositis in Japanese patients. (1998) (40)
Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population. (2007) (40)
Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese (2009) (40)
HLA‐A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese (2014) (40)
Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. (2007) (39)
Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations (2008) (39)
Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population (2011) (39)
Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis. (2004) (38)
Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population. (2003) (38)
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population (2012) (37)
Association Test Algorithm Between a Qualitative Phenotype and a Haplotype or Haplotype Set Using Simultaneous Estimation of Haplotype Frequencies, Diplotype Configurations and Diplotype-Based Penetrances (2004) (37)
HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study (2013) (37)
A role of monocyte chemoattractant protein‐4 (MCP‐4)/CCL13 from chondrocytes in rheumatoid arthritis (2007) (37)
Microchimerism in Japanese patients with systemic sclerosis. (2001) (36)
[Pharmacogenetics of disease modifying anti-rheumatic drugs]. (2002) (36)
Are minor alleles more likely to be risk alleles? (2018) (36)
Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population (2007) (36)
Effect of Genetic Polymorphisms on Development of Gout (2013) (35)
Pharmacokinetics and Pharmacodynamics of Febuxostat (TMX‐67), a Non‐Purine Selective Inhibitor of Xanthine Oxidase/Xanthine Dehydrogenase (NPSIXO) in Patients with Gout and/or Hyperuricemia (2004) (35)
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1). (2006) (35)
IP-10/MCP-1 ratio in CSF is an useful diagnostic marker of neuropsychiatric lupus patients. (2006) (35)
Common Variants in a Novel Gene, FONG on Chromosome 2q33.1 Confer Risk of Osteoporosis in Japanese (2011) (35)
IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. (2012) (35)
Impact of viral amino acid substitutions and host interleukin‐28b polymorphism on replication and susceptibility to interferon of hepatitis C virus (2011) (35)
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene. (2009) (35)
Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line. (1983) (35)
Genetic polymorphisms of UGT1A6 in a Japanese population. (2005) (35)
Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis. (2008) (35)
Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. (2006) (34)
Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases. (2004) (34)
Genome‐wide association study on bipolar disorder in the Bulgarian population (2011) (34)
Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al. (2004) (34)
A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosus. (2003) (33)
Relative transcriptional activities of SAA1 promoters polymorphic at position −13(T/C): Potential association between increased transcription and amyloidosis (2005) (33)
Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state (2011) (33)
Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus (2007) (33)
MHC2TA is associated with rheumatoid arthritis in Japanese patients (2006) (33)
SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population (2011) (33)
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer (2006) (32)
Human anticentriole autoantibody in patients with scleroderma and Raynaud's phenomenon. (1983) (32)
Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15. (2007) (31)
One third of Japanese patients with rheumatoid arthritis use complementary and alternative medicine (2006) (31)
A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis (2012) (31)
Lymphocyte dysfunction caused by deficiencies in purine metabolism. (1981) (31)
Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese (2012) (31)
Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus (2005) (31)
Declining use of synovectomy surgery for patients with rheumatoid arthritis in Japan (2009) (30)
Genome Wide Association Study of Age at Menarche in the Japanese Population (2013) (30)
Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians (2011) (30)
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells. (1983) (30)
Differential binding avidities of human IgM for staphylococcal protein A derive from specific germ-line VH3 gene usage. (1996) (29)
Strategies for genome-wide association studies: optimization of study designs by the stepwise focusing method (2002) (29)
Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study (2008) (28)
Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population (2005) (28)
Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population (2007) (28)
Clinical features of familial gout and effects of probable genetic association between gout and its related disorders. (2001) (28)
A mutant allele common to the type I adenine phosphoribosyltransferase deficiency in Japanese subjects. (1991) (28)
Reversed-phase liquid-chromatographic determination of purine compounds in serum applied to studies of hypouricemia. (1986) (27)
Identification of independent risk loci for Graves’ disease within the MHC in the Japanese population (2011) (27)
Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. (2008) (27)
CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population (2007) (27)
A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population (2008) (27)
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA. (2000) (27)
Diagnosis of heterozygous states for adenine phosphoribosyltransferase deficiency based on detection of in vivo somatic mutants in blood T cells: application to screening of heterozygotes. (1991) (27)
Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA (2010) (27)
Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility (2011) (27)
An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel (2012) (27)
Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients. (2008) (26)
A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction (2007) (26)
Postoperative complications in patients with rheumatoid arthritis using a biological agent – A systematic review and meta-analysis (2015) (26)
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. (2014) (26)
Expression of hepatocyte growth factor and its receptor (c-met) in skin fibroblasts from patients with systemic sclerosis. (2002) (26)
Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study. (2011) (25)
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients (2009) (25)
The Textile Plot: A New Linkage Disequilibrium Display of Multiple-Single Nucleotide Polymorphism Genotype Data (2010) (25)
Molecular basis for the interaction between human IgM and staphylococcal protein A. (1994) (25)
Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (2007) (25)
Analysis of germline and in vivo somatic mutations in the human adenine phosphoribosyltransferase gene: mutational hot spots at the intron 4 splice donor site and at codon 87. (1993) (25)
Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region (2018) (25)
FUNCTIONAL ANALYSIS OF SIX HUMAN ARYL HYDROCARBON RECEPTOR VARIANTS IN A JAPANESE POPULATION (2005) (25)
Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population (2008) (25)
Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease. (2007) (25)
High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population (2007) (25)
Multicenter, Open-Label Study of Long-Term Administration of Febuxostat (TMX-67) in Japanese Patients With Hyperuricemia Including Gout (2011) (24)
Rheumatoid Factors Induce Signaling from B Cells, Leading to Epstein-Barr Virus and B-Cell Activation (2004) (24)
Altered kinetic properties of a mutant adenine phosphoribosyltransferase. (1986) (24)
Prevalence of Helicobacter pylori infection and risk of upper gastrointestinal ulcer in patients with rheumatoid arthritis in Japan (2005) (24)
Risk factors for total knee arthroplasty in rheumatoid arthritis (2007) (24)
Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis. (1996) (24)
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme. (1981) (24)
Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility (2008) (24)
Genetic Variations and Haplotype Structures of the ABCB1 Gene in a Japanese Population: An Expanded Haplotype Block Covering the Distal Promoter Region, and Associated Ethnic Differences (2006) (24)
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients (2008) (24)
A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone. (2010) (24)
Responsiveness of peripheral blood B cells to recombinant CD40 ligand in patients with systemic lupus erythematosus (1999) (23)
Analysis of the genotypes for aldehyde dehydrogenase 2 in Japanese patients with primary gout. (1994) (23)
Distribution of patients with 2,8-dihydroxyadenine urolithiasis and adenine phosphoribosyltransferase deficiency in Japan. (1988) (23)
Soluble fractalkine in the cerebrospinal fluid of patients with neuropsychiatric lupus (2006) (23)
Development of a SNP set for human identification: A set with high powers of discrimination which yields high genetic information from naturally degraded DNA samples in the Thai population. (2014) (23)
Similarity of the allele frequency and linkage disequilibrium pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern East Asian populations: implications for tagging SNP selection in Thais (2006) (22)
Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese. (2007) (22)
Common characteristics of mutant adenine phosphoribosyltransferases from four separate Japanese families with 2,8-dihydroxyadenine urolithiasis associated with partial enzyme deficiencies (2004) (22)
A CCR-5 antagonist inhibits the development of adjuvant arthritis in rats. (2006) (22)
Novel prion protein polymorphisms in cattle. (2003) (22)
Genetic Polymorphisms and Haplotypes of the Human Cardiac Sodium Channel α Subunit Gene (SCN5A) in Japanese and their Association with Arrhythmia (2005) (22)
Cartilage oligomeric matrix protein in serum and synovial fluid of rheumatoid arthritis: potential use as a marker for joint cartilage damage (2004) (21)
Troglitazone decreases serum uric acid concentrations in Type II diabetic patients and non-diabetics (2000) (21)
Replication of association of the D-repeat polymorphism in asporin with osteoarthristis (2006) (21)
High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis. (2007) (20)
Screening for adenine and hypoxanthine phosphoribosyltransferase deficiencies in human erythrocytes by high-performance liquid chromatography. (1987) (20)
Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population. (2009) (20)
Successful treatment with fenofibrate, a peroxisome proliferator activated receptor α ligand, for a patient with rheumatoid arthritis (2004) (20)
A new method for the detection of Lesch-Nyhan heterozygotes by peripheral blood T cell culture using T cell growth factor. (1984) (20)
Deficient activity of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura in the setting of adult-onset Still's disease. (2006) (20)
Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study. (2011) (20)
Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome. (2001) (20)
Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm. (2002) (20)
T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (2009) (19)
Japan PGx Data Science Consortium Database: SNPs and HLA genotype data from 2994 Japanese healthy individuals for pharmacogenomics studies (2015) (19)
Ulcerative colitis followed by the development of Behçet's disease. (2004) (19)
Identification of an IL1A gene segment that determines aberrant constitutive expression of interleukin-1 alpha in systemic sclerosis. (2003) (19)
Spinal tophaceous gout mimicking a spinal tumor. (2004) (19)
Irsogladine is Effective for Recurrent Oral Ulcers in Patients with Behçet’s Disease (2008) (19)
CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population (2007) (19)
Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study (2006) (18)
Rapidly progressive glomerulonephritis with D-penicillamine. (2000) (18)
Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene (2013) (18)
Low disease activity state with corticosteroid may not represent 'true' low disease activity state in patients with rheumatoid arthritis. (2007) (18)
Synovial histology in three Behçet's disease patients with orthopedic surgery. (2002) (18)
Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA (2006) (18)
Progressive appearance of overlap syndrome together with autoantibodies in a patient with fatal thrombotic microangiopathy. (2000) (17)
Geranylgeranylacetone Inhibits Formation and Function of Human Osteoclasts and Prevents Bone Loss in Tail-Suspended Rats and Ovariectomized Rats (2005) (17)
Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms. (1990) (17)
Theophylline increases serum uric acid levels. (1984) (17)
Liquid chromatography with multichannel ultraviolet detection used for studying disorders of purine metabolism. (1987) (17)
A polymorphism in the gene encoding the Fcγ IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis (2008) (17)
Cricoarytenoid arthritis with rheumatoid arthritis and systemic lupus erythematosus. (2001) (17)
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). (2008) (17)
Relationship between phosphorylation and cytotoxicity of 2-chloroadenosine and 6-methylmercaptopurine riboside in human cells. (1984) (17)
[Nation-wide survey for the treatment with cyclosporin A of interstitial pneumonia associated with collagen diseases]. (1999) (16)
Detection of an amino acid substitution in the mutant enzyme for a special type of adenine phosphoribosyltransferase (APRT) deficiency by sequence-specific protein cleavage. (1989) (16)
A germline mutation abolishing the original stop codon of the human adenine phosphoribosyltransferase (APRT) gene leads to complete loss of the enzyme protein (1998) (16)
Genome-wide association study of epirubicin-induced leukopenia in Japanese patients (2011) (16)
[A case of intestinal Behçet's disease with abnormal ossification complicated by myelodysplastic syndrome, symptoms revealed after the perforation of ileum ulcer]. (2000) (15)
The origin of the most common mutation of adenine phosphoribosyltransferase among Japanese goes back to a prehistoric era (1996) (15)
Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells (1995) (15)
Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese (2008) (15)
Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP (2019) (15)
Characterization of an adenosine deaminase-deficient human histiocytic lymphoma cell line (DHL-9) and selection of mutants deficient in adenosir kinase and deoxycytidine kinase. (1983) (15)
Failure to confirm association between SLC22A4 polymorphism and rheumatoid arthritis in a Japanese population. (2005) (15)
Attenuation of Experimental Autoimmune Myositis by Blocking ICOS-ICOS Ligand Interaction1 (2007) (15)
Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies (2011) (15)
Impact of PSCA Variation on Gastric Ulcer Susceptibility (2013) (14)
A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis (2009) (14)
PlatinumCNV: A Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data (2011) (14)
The Universal Trend of Amino Acid Gain–Loss is Caused by CpG Hypermutability (2008) (14)
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes (2003) (14)
A model of prediction system for adverse cardiovascular reactions by calcineurin inhibitors among patients with renal transplants using gene-based single-nucleotide polymorphisms (2005) (14)
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. (2011) (14)
Cluster analysis and association study of structured multilocus genotype data (2005) (13)
5'-Methylthioadenosine is the major source of adenine in human cells. (1984) (13)
Adenine phosphoribosyltransferase deficiency identified by urinary sediment analysis: cellular and molecular confirmation (1995) (13)
Web-based detection of genotype errors in pedigree data (2002) (13)
A recurrent large Alu‐mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch‐Nyhan syndrome (2001) (13)
Systematic evaluation of personal genome services for Japanese individuals (2013) (13)
5'-Methylthioadenosine in urine from normal subjects and cancer patients. (1984) (13)
Xanthine Oxidase Inhibitor Withdrawal Syndrome? Comment on the Article by Choi et al (2019) (13)
Prediction of response to peginterferon‐alfa‐2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b (2011) (13)
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS). (2006) (13)
Clonal analysis of T cell infiltrates in synovial tissue of patients with rheumatoid arthritis. (1990) (12)
Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan (2014) (12)
New pharmacogenetic test for detecting an HLA-A*31: 01 allele using the InvaderPlus assay (2012) (12)
Evaluation of Differences in Automated QT/QTc Measurements between Fukuda Denshi and Nihon Koden Systems (2014) (12)
Raised plasma adrenomedullin level in Behçet's disease patients (2003) (12)
Modulation of the onset age in primary dystonia by APOE genotype (2003) (12)
Multiple extra-articular synovial cyst formation: case report and review of the literature (1998) (12)
Radiopaque 2,8-Dihydroxyadenine Lithiasis (2004) (12)
Clinical verification of a combination technology of a loop-mediated isothermal amplification method and an electrochemical DNA chip for personalized medicine. (2009) (12)
Genotypes at SAA1 locus correlate with the clinical severity of AA-amyloidosis (2001) (12)
Efficacy of bezafibrate in a patient with primary sclerosing cholangitis (2003) (12)
Myelodysplastic Syndrome Associated with Low-dose Methotrexate in Rheumatoid Arthritis (2004) (12)
Test of Association Between Haplotypes and Phenotypes in Case–Control Studies: Examination of Validity of the Application of an Algorithm for Samples From Cohort or Clinical Trials to Case–Control Samples Using Simulated and Real Data (2006) (12)
Japanese single nucleotide polymorphism database for 267 possible drug‐related genes (2006) (12)
Direct evidence for a hot spot of germline mutation at HPRT locus. (1994) (11)
Polyglutamation of antifolates is not required for induction of extracellular release of adenosine or expression of their anti-inflammatory effects. (2000) (11)
Pancytopenia and Colitis with Clostridium difficile in a Rheumatoid Arthritis Patient Taking Methotrexate, Antibiotics and Non-steroidal Anti-inflammatory Drugs (2001) (11)
A case of relapsing polychondritis with bilateral sensorineural hearing loss and perforation of the nasal septum at the onset (2007) (11)
Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. (2006) (11)
Vasopressin cell antibodies and central diabetes insipidus in a patient with systemic lupus erythematosus and dermatomyositis. (2004) (11)
Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C. (2012) (11)
Haplotype analysis of human AMPD1 gene: origin of common mutant allele (2004) (11)
Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis. (2008) (11)
Formation of DNA strand breaks by D-penicillamine and bucillamine in human lymphocytes. (1993) (10)
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL 6 locus (2011) (10)
The Role of IL-17 in Joint Destruction. (2002) (10)
A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia (2011) (10)
An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study. (2011) (10)
Establishment and characterization of B cell lines from individuals with various types of adenine phosphoribosyltransferase deficiencies. (1986) (10)
A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers. (2007) (10)
Down syndrome with coexistent gout: report of six patients and possible reasons for the scarcity of descriptions of this association. (1996) (10)
Comparison of the Rau method and the Larsen method in the evaluation of radiographic progression in early rheumatoid arthritis. (2002) (10)
Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritis. (2008) (10)
Differential composition of cytosol 5'-nucleotidases between T and B lymphoblasts. (1986) (10)
Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine (2020) (10)
Simultaneous Estimation of Haplotype Frequencies and Quantitative Trait Parameters (2004) (10)
A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5 q 35 . 3 , 7 p 14 . 3 , and 13 q 14 . 1 (2012) (9)
Polynomial Time Approximate Sampler for Discretized Dirichlet Distribution (2003) (9)
[A case of amyopathic dermatomyositis with rapidly progressive interstitial pneumonia]. (2000) (9)
Crossovers within a short DNA sequence indicate a long evolutionary history of the APRT*J mutation (1990) (9)
A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population (2017) (9)
Sequential metabolism of 5'-isobutylthioadenosine by methylthioadenosine phosphorylase and purine-nucleoside phosphorylase in viable human cells. (1982) (9)
The process of collecting and evaluating evidences for the development of Guidelines for the management of rheumatoid arthritis, Japan College of Rheumatology 2014: Utilization of GRADE approach (2016) (9)
Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophilia (2005) (9)
Genetic differences in the two main groups of the Japanese population based on autosomal SNPs and haplotypes (2012) (9)
Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population (2016) (9)
Familial Juvenile Gouty Nephropathy: Exclusion of 16p12 from the Candidate Locus (2002) (9)
Detection of the most common mutation of adenine phosphoribosyltransferase deficiency among Japanese by a non-radioactive method. (1991) (9)
Correction: Genome Wide Association Study of Age at Menarche in the Japanese Population (2013) (9)
Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. (2013) (9)
[Leflunomide: clinical effectiveness and mechanism of action]. (2003) (9)
Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population. (2004) (9)
Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. (2007) (9)
An asymptomatic germline missense base substitution in the hypoxanthine phosphoribosyltransferase (HPRT) gene that reduces the amount of enzyme in humans (1996) (9)
Phosphoribosylpyrophosphate synthetase in human erythrocytes: assay and kinetic studies using high-performance liquid chromatography. (1991) (9)
Cross-resistance to ouabain in a murine leukemia cell variant selected for cis-dichlorodiammineplatinum(II) resistance. (1987) (9)
Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase. (1983) (9)
Serum PAI‐1 is a novel predictor for response to pegylated interferon‐α‐2b plus ribavirin therapy in chronic hepatitis C virus infection (2012) (8)
Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs (2018) (8)
Optimal range of serum urate concentrations to minimize risk of gouty attacks during antihyperuricemic treatment (1997) (8)
Hypouricaemic effect after oral administration in chickens of polyethylene glycol‐modified uricase entrapped in liposomes (1984) (8)
Case of Chlamydia-associated arthritis. (2009) (8)
Risk factors for wrist surgery in rheumatoid arthritis (2008) (8)
Association of a polymorphism in the monocyte chemoattractant protein-1/CCL2 gene and lupus nephritis in systemic lupus erythematosus patients. (2008) (8)
Nonsteroidal anti-inflammatory drug use does not affect short-term endoscopic and histologic outcomes after Helicobacter pylori eradication in patients with rheumatoid arthritis (2007) (8)
Clinical studies on changes in purine compounds in blood and urine by the simultaneous administration of febuxostat and inosine, or by single administration of each (2017) (8)
Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase deficiency in Japanese patients. (1991) (8)
A Comparative Study to Assess the Efficacy, Safety, and Immunogenicity of YLB113 and the Etanercept Reference Product for the Treatment of Patients with Rheumatoid Arthritis (2019) (8)
[Case of systemic sclerosis presenting with alveolar hemorrhage and positive anti-neutrophil cytoplasmic myeloperoxidase antibody(MPO-ANCA) without pathological renal involvement]. (2003) (8)
Differential inhibition of lymphocyte function by 2-chloroadenosine. (1984) (8)
Raised plasma adrenomedullin in patients with systemic sclerosis complicated by pulmonary hypertension (2000) (8)
A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresis (2006) (8)
Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients (2007) (8)
Comparison between various strategies for the disease-gene mapping using linkage disequilibrium analyses: studies on adenine phosphoribosyltransferase deficiency used as an example (2004) (8)
Novel genetic variations and haplotypes of hepatocyte nuclear factor 4alpha (HNF4A) found in Japanese type II diabetic patients. (2006) (8)
Selection of human cells having two different types of mutations in individual cells (genetic/artificial mutants) (1987) (7)
Detection and significance of anti-mitochondrial antibody in various collagen diseases (2007) (7)
ITGAV polymorphism and disease susceptibility in a Japanese rheumatoid arthritis population (2007) (7)
Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick–Kaufman syndrome gene variants are associated with metabolic syndrome (2009) (7)
Therapeutic Effects of Alendronate on Bone Erosion and Atrophy in a Patient with Rheumatoid Arthritis and Hepatitis C Virus Infection (2008) (7)
Evaluation of the severity of hypoxanthine-guanine phosphoribosyltransferase deficiency using viable T cells. (1985) (7)
Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes (2010) (7)
Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside (1979) (7)
Differential cyst(e)ine requirements in human T and B lymphoblastoid cell lines. (1982) (7)
Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments (2017) (7)
Identification of a compound heterozygote for adenine phosphoribosyltransferase deficiency (APRT*J/APRT*Q0) leading to 2,8-dihydroxyadenine urolithiasis (1990) (7)
Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. (2008) (7)
New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations (2008) (7)
Protective effect of A at position –168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosus (2007) (7)
Hypoxanthine guanine phosphoribosyltransferase deficiency: nucleotide substitution causing Lesch-Nyhan syndrome identified for the first time among Japanese (1990) (7)
Clinical utility of computed tomographic scanning for the evaluation of lupus profundus in two patients with systemic lupus erythematosus (2009) (7)
Differential cytotoxic effects of mizoribine and its aglycone on human and murine cells and on normal and enzyme-deficient human cells. (1995) (7)
Estimation of haplotype associated with several quantitative phenotypes based on maximization of area under a receiver operating characteristic (ROC) curve (2006) (7)
Two Japanese cases with MAGIC syndrome (mouth and genital ulcers with inflamed cartilage). (2006) (7)
Myocardial dysfunction in a patient with adult-onset Still's disease (AOSD). (2004) (6)
Asymptomatic interstitial pneumonitis induced by bucillamine in a patient with rheumatoid arthritis (2005) (6)
Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs) (2008) (6)
Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients. (2011) (6)
Influences of ethanol on 5-phosphoribosyl-1-pyrophosphate concentration and purine-metabolizing enzyme activities in the mouse liver. (1979) (6)
Dermatomyositis with splenic and renal infarctions during corticosteroid therapy. (2000) (6)
Rituximab for rheumatoid arthritis. (2004) (6)
Alpha Hemoglobin Stabilizing Protein (AHSP) Is a Susceptibility Gene to Drug /Infection-Induced Hemolytic Anemia. (2005) (6)
Rapidly destructive knee arthropathy associated with hepatitis B. (2006) (6)
Antiphospholipid syndrome with complete abdominal aorta occlusion and chondritis (2001) (6)
Systemic lupus erythematosus with myocardial dysfunction due to microvasculopathy (2000) (6)
Putrescine dependent growth of mycoplasma infected mammalian cells (1983) (6)
Renal function estimated from serum creatinine is overestimated in patients with rheumatoid arthritis because of their muscle atrophy (2000) (6)
[A case of recurrent hemophagocytic syndrome complicated with systemic sclerosis: relationship between disease activity and serum level of IL-18]. (2001) (6)
Reversed-phase high-performance liquid-chromatography of 2,8-dihydroxyadenine in serum and urine with electrochemical detection. (1989) (6)
ParaHaplo: A program package for haplotype-based whole-genome association study using parallel computing (2009) (6)
An angiotensin receptor blocker suppresses monocyte chemoattractant protein 1 production from rheumatoid synovial fibroblasts: comment on the article by Sagawa et al. (2005) (5)
Subject Index, Vol. 35, 1985 (1985) (5)
A role for TARC/CCL17, a CC chemokine, in New Zealand mice. (2005) (5)
Hypersensitivity reaction against influenza vaccine in a patient with rheumatoid arthritis after the initiation of etanercept injections (2006) (5)
Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus (2000) (5)
Integrating patients’ perceptions into clinical practice guidelines for the management of rheumatoid arthritis in Japan (2017) (5)
A case of psoriatic arthritis without the appearance of psoriatic skin or nail lesions for 21 years (2007) (5)
Delayed therapy with curative intent in a contemporary prostate cancer watchful‐waiting cohort (2004) (5)
Pseudodominant transmission of an autosomal recessive disease, adenine phosphoribosyltransferase deficiency. (1991) (5)
Decrease in the reaction of DNA repair synthesis in response to nicotinamide or 3-aminobenzamide in ultraviolet irradiated systemic lupus erythematosus lymphocytes. (1985) (5)
Cryptogenic organizing pneumonia in two patients with Behçet's disease. (2007) (5)
Clinical aspects of gouty patients in Taiwan. (1989) (5)
Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome (2008) (5)
[Etoposide ameliorated refractory hemophagocytic syndrome in a patient with systemic sclerosis]. (2002) (5)
Successful treatment with fenofibrate of autoimmune hepatitis in a patient with rheumatoid arthritis (2007) (5)
Polynomial time approximate or perfect samplers for discretized Dirichlet distribution (2010) (5)
[A case of Sjögren's syndrome and systemic sclerosis complicated with acute pancreatitis]. (2000) (5)
Dermatomyositis associated with autoimmune idiopathic thrombocytopenia and anti-Ku antibody (2004) (4)
Identification of Two Novel Mutations in Adenine Phosphoribosyltransferase Gene in Patients with 2,8‐Dihydroxyadenine Urolithiasis (2004) (4)
Biochemical basis for lymphocyte dysfunction in adenosine deaminase and purine nucleoside phosphorylase deficiencies. (1984) (4)
[A case of microscopic polyangiitis with severe cardiac and respiratory muscle involvement]. (1999) (4)
Genome‐wide association study of epilepsy in a Japanese population identified an associated region at chromosome 12q24 (2021) (4)
Abstracts from the 9th Biennial Scientific Meeting of the Asia Pacific Paediatric Endocrine Society (APPES) and the 50th Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE) (2017) (4)
[Pharmacogenomics of antirheumatic drugs and personalized medicine for rheumatoid arthritis]. (2007) (4)
5'-Methylthioadenosine phosphorylase deficiency in malignant cells: recessive expression of the defective phenotype in intraspecies (mouse X mouse) hybrids. (1984) (4)
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects (2009) (3)
Tubular function impairment in patients with asymptomatic hyperuricemia. (1977) (3)
Causes of Death in Autopsied Patients with Rheumatoid Arthritis in Japan (2013) (3)
Classification of systemic sclerosis in the Japanese population based on rapid progression of skin thickening (2004) (3)
Grouping preprocess to accurately extend application of EM algorithm to haplotype inference (2008) (3)
Suppression of cellular immunity due to inhibition of purine nucleoside phosphorylase by allopurinol-riboside. (1979) (3)
The use survey of antihyperuricemic in clinicians (2018) (3)
Diagnosis of genotypes for adenine phosphoribosyltransferase (APRT) deficiency. (1989) (3)
Microanalysis of Pathological Crystals and Urinary Calculi (1998) (3)
Single-nucleotide polymorphisms in GALNT 8 are associated with the response to interferon therapy for chronic hepatitis C (2012) (3)
Six-layer structure for genomics and its applications (2015) (3)
Combining effects of polymorphism of tumor necrosis factor α 5′-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis (2009) (3)
2-Chloroadenosine is phosphorylated and increases the production of hypoxanthine in human cells. (1986) (3)
Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis (2020) (3)
[Abnormalities in urate metabolism: concept and classification]. (1996) (3)
SAA1 Gene Analysis in Finnish Patients with AA Amyloidosis (2004) (3)
Human Adenine Phosphoribosyltransferase (APRT) Deficiency: Single Mutant Allele Common to the Japanese (1989) (3)
[Insulin sensitizer and urate metabolism]. (2000) (3)
Disturbance in the metabolism of 5'-methylthioadenosine and adenine in patients with neoplastic diseases, and in those with a deficiency in adenine phosphoribosyltransferase. (1991) (3)
[Adenine phosphoribosyltransferase (APRT)]. (1996) (3)
[Statistical methods in genetic analysis]. (2010) (3)
Immune thrombocytopenic purpura associated with rheumatoid arthritis – a report of five cases and review of the literature (2001) (3)
[A case of systemic lupus erythematosus complicated by Nocardia farcinica]. (1999) (2)
pHCR: a Parallel Haplotype Configuration Reduction algorithm for haplotype interaction analysis (2009) (2)
SINGLE NUCLEOTIDE POLYMORPHISMS AND HAPLOTYPE FREQUENCIES OF UGT 2 B 4 AND UGT 2 B 7 IN A JAPANESE POPULATION (2004) (2)
Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus (1997) (2)
Rapid method for the diagnosis of partial adenine phosphoribosyltransferase deficiencies causing 2,8-dihydroxyadenine urolithiasis (2004) (2)
The origin of APRT*J. The most common disease-related mutation of APRT gene among Japanese goes back to a prehistoric era. (1998) (2)
The effect of geranylgeranylacetone on human osteoclastogenesis and synovitis in patients with rheumatoid arthritis (2008) (2)
The occurrence of Japanese cedar pollinosis with rheumatoid arthritis. (2007) (2)
Genes, the brain, and artificial intelligence in evolution (2020) (2)
The role of vitamin K2 and geranylgeranylacetone information and function of osteoclasts (2004) (2)
Guillain-Barré syndrome accompanied by central nervous system lupus in a patient with juvenile rheumatoid arthritis (2001) (2)
Accurate automated clustering of two-dimensional data for single-nucleotide polymorphism genotyping by a combination of clustering methods: evaluation by large-scale real data (2007) (2)
A systematic review and meta-analysis on the safety and efficacy of different strains of Mycobacterium bovis bacillus Calmette-Guérin for non-muscle invasive bladder cancer in Japan and US (2015) (2)
Pharmacodynamics of TMX-67 (TEI-6720), a novel xanthien dehydrogenase/oxidase inhibitor, in man (1997) (2)
A germ line mutation within the coding sequence for the putative 5-phosphoribosyl-1-pyrophosphate binding site of hypoxanthine-guanine phosphoribosyltransferase (HPRT) in a Lesch-Nyhan patient: missense mutations within a functionally important region probably cause disease (1992) (2)
Common altered characteristics of mutant enzymes from patients with Japanese type APRT deficiencies. (1986) (2)
A functional variant in NKX 3 . 1 associated with prostate cancer susceptibility down-regulates NKX 3 . 1 expression (2010) (2)
[Association of polymorphisms in genes of osteoclastogenesis-related cytokines with severity in patients with rheumatoid arthritis]. (2005) (2)
In vitro enhancement of ATP in human erythrocytes from a healthy subject and two patients with thalassemia and hemoglobinopathy. (2018) (2)
Title: Post-Marketing Surveillance of the Safety Profile of Infliximab in 5,000 Japanese Patients with Rheumatoid Arthritis (2007) (2)
[Crystal induced arthritis]. (1997) (2)
ParaHaplo 3.0: A program package for imputation and a haplotype-based whole-genome association study using hybrid parallel computing (2011) (2)
Grouping preprocess for haplotype inference from SNP and CNV data (2009) (2)
Sjögren's syndrome in one of two sisters with idiopathic renal hypouricemia. (1994) (2)
Pharmacogenetics of disease-modifying anti-rheumatic drugs. (2004) (2)
Mutations in xanthine dehydrogenase gene in subjects with hereditary xanthinuria. (1998) (2)
[Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats]. (2004) (2)
Recent trend in the onset age of gouty arthritis in Japan (2004) (2)
Measurement of 5′‐methylthioadenosine in patients with neoplasms (1990) (2)
Selection of mutant murine lymphoid cells partially deficient in S-adenosylhomocysteine hydrolase (1982) (2)
[MPO-ANCA positive rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with D-penicillamine]. (1999) (2)
A case of systemic lupus erythematosus presenting transverse myelitis after an episode of meningitis (2005) (2)
[Isolated pulmonary hypertension in overlap syndrome: successful treatment by methylprednisolone pulse therapy]. (2003) (2)
[Adenine phosphoribosyltransferase(APRT) deficiency]. (1996) (2)
Making a haplotype catalog with estimated frequencies based on SNP homozygotes (2010) (2)
Retrospective analysis of liver toxicity due to anti-hvperuricemic drugs in Japan (2001) (1)
The prevalence of purine metabolic disorders in Japan. (1986) (1)
[Effects of alcohol on urate metabolism]. (1997) (1)
THE PREVALENCE OF PURINE METABOLIC DISORDERS IN JAPAN: 143 (1985) (1)
Genome-Wide Association Study in Thai Tsunami Survivors Identified Risk Alleles for Posttraumatic Stress Disorder (2015) (1)
AB0416 A COMPARATIVE STUDY TO ASSESS THE EFFICACY, SAFETY, AND IMMUNOGENICITY OF YLB113 AND ETANERCEPT REFERENCE PRODUCT FOR THE TREATMENT OF PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS (2019) (1)
Erythrocyte adenine PRPP availability in two types of APRT deficiency using silicon oil method. (1989) (1)
Germline and somatic mutations leading to adenine phosphoribosyltransferase (APRT) deficiency. (1991) (1)
A new standard of care? Studies on febuxostat in the management of hyperuricemia with and without gout. (2011) (1)
Association tests and estimation of haplotype frequencies and of penetrance-related parameters in a case-control study (2004) (1)
Unusual presentations of thoracic tumors: Case 2. Malignant mesothelioma mimicking rheumatoid pleurisy. (2001) (1)
PMS55 EURO QOL (EQ-5D) BASED QOL (QUALITY OF LIFE) IN 5,023 JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS (RA) PATIENTS IN AN OBSERVATIONAL COHORT IORRA (2008) (1)
Diagnosis and treatment of metabolism and endocrine diseases. Recent advance. Gout and osteoporosis. Nucleic acid metabolic disorder and gout. (1997) (1)
[Genotype and genetic diagnosis of APRT deficiency]. (1992) (1)
[Abnormalities in nucleic acid metabolism and gout]. (1997) (1)
Aromatase inhibitors , estrogens and musculoskeletal pain : estrogen-dependent T-cell leukemia 1 A ( TCL 1 A (2012) (1)
JAPANESE PATIENTS WITH PARTIAL APRT DEFICIENCIES ACCOMPANIED WITH 2,8-DIHYDROXYADENINE LITHIASIS SYNTHESIZE MUTANT APRT WITH ALTERED KINETIC PROPERTIES WHICH DOES NOT FUNCTION IN VIABLE CELLS: 98 (1985) (1)
A case of interstitial pneumonia antedating rheumatoid arthritis. (1989) (1)
A case of mixed connective tissue disease with cystic pancreatitis: successful treatment by cyclophosphamide. (2001) (1)
Enhancement of the rate of spontaneous mutation to 6-thioguanine resistance in mammalian cells by polyamine depletion. (1984) (1)
Partial hypoxanthine phosphoribosyltransferase deficiency: unrecognized until adult ages. (1998) (1)
144 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES MULTIPLE NEW SUSCEPTIBILITY LOCI FOR PROSTATE CANCER IN JAPANESE POPULATION (2011) (1)
Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach (2019) (1)
Selective inhibition of cytotoxic T lymphocyte proliferation by mizoribine (bredinin), an adenosine analog. (1989) (1)
Similarity of in vivo somatic mutations at an autosomal adenine phosphoribosyltransferase locus between T- and B-cells in human peripheral blood. (1996) (1)
Multiple dislocations of distal interphalangeal joints associated with interstitial pneumonia and Sjögren's syndrome: a possible new complex. (2000) (1)
Dipyridamole stress thallium perfusion scan for evaluating myocardial involvement in systemic sclerosis (2001) (1)
ParaHaplo 2.0: a program package for haplotype-estimation and haplotype-based whole-genome association study using parallel computing (2010) (1)
Cross-sectional analysis of NSAID-related gastrointestinal injury in patients with RA (2002) (1)
[A case of partial deficiency of hypoxanthine-guanine phosphoribosyltransferase]. (1988) (1)
[Contribution of angiotensin II type I and type II receptors(AT-1 and AT-2) to collagen synthesis by skin fibroblasts]. (2002) (1)
A first evidence for an asymptomatic germline missense mutation in the hypoxanthine phosphoribosyltransferase (HPRT) gene in humans (1997) (1)
Febuxostat ; a non-purine xanthine oxidase inhibitor useful for the treatment of gout and hyperuricemia (2011) (1)
Studies on safety and efficacy of particles containing a mixture of hydroxyapatite–argentum–titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: II. Cellular, in vivo, and clinical studies (2022) (1)
Clinical features of juvenile gout in Taiwan (2006) (1)
55 HUMAN ADENINE PHOSPHORIBOSYLTRANSFERASE (APRT) DEFICIENCY: A SINGLE MUTANT ALLELE COMMON TO THE JAPANESE (1988) (1)
Above-normal concentrations of lipid peroxide in serum of patients with gout. (1984) (1)
Extra-articular complications of rheumatoid arthritis: a review of recent literature (1997) (1)
Regulation of aging by balancing mitochondrial function and antioxidant levels (2022) (1)
Saa1 gene analysis in the patients with aa-amyloidosis from three different populations. (2002) (1)
Microanalysis of pathological crystals and urinary calculi. (1997) (1)
Generation and molecular characterisation of monoclonal IgG4 rheumatoid factor from a patient with rheumatoid arthritis (1997) (1)
A case of dermatomyositis assosiated with digital gangrene and skin eruption improved by vitamim A (1992) (1)
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression (2012) (1)
A new syndrome: multiple dislocations of distal interphalangeal joints associated with interstitial pneumonia, Sjögren's syndrome, and positive autoantibodies (2003) (0)
Serum level of matrix metalloproteinase-3 as a useful marker for predicting the progression of joint destruction in patients with early rheumatoid arthritis (2001) (0)
[Current status of researches in genomic medicine and the guidelines for pharmacogenomics (PGx)]. (2011) (0)
[5-Phosphoribosyl-1-pyrophosphate synthetase overexpression]. (1998) (0)
607 A FUNCTIONAL VARIANT IN NKX3.1 ASSOCIATED WITH PROSTATE CANCER SUSCEPTIBILITY DOWN-REGULATES NKX3.1 EXPRESSION (2011) (0)
The importance of methylthioadenosine phosphorylase deficiency in human malignancy (1982) (0)
A Case of Autoimmune Hepatitis Associated with Veno-occlusive Disease and Primary Sclerosing Cholangitis (2004) (0)
Title: A Polymorphism in MAPKAPK3 Affects Response to Interferon Therapy for Chronic Hepatitis C Short Title: MAPKAPK3 and IFN therapy for HCV infection (2009) (0)
Estimation of the risk of a qualitative phenotype: dependence on population risk (2016) (0)
Gene diagnosis and treatment. (1993) (0)
[From clinical tests to etiology: analysis of clinical features. Adenine phosphoribosyltransferase deficiency]. (1987) (0)
COMPARISON OF SURFACE DIFFERENTIATION ANTIGENS BETWEEN SEPARATED HGPRT-POSITIVE AND NEGATIVE T-CELL POPULATIONS FROM TWO LESCH-NYHAN HETEROZYGOTES: 233 (1985) (0)
Combining effects of polymorphism of tumor necrosis factor α 5′-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis (2009) (0)
Multiple distal interphalangeal joint dislocation (2000) (0)
[Methods of statistical genetics and use of database for genome information]. (2005) (0)
Perspectives and problem points in gene therapy. (1988) (0)
Characterization of the cloned rheumatoid synovial cells in long-term culture. (1987) (0)
ProspectiveStudyoftheAssociationBetween NAT2 Gene HaplotypesandSevereAdverseEventswithSulfasalazine TherapyinPatientswithRheumatoidArthritis (2008) (0)
[Possible roles of TNF family cytokines in bone destruction of rheumatoid arthritis]. (2002) (0)
Microdeletion at ESR1 Intron 6 (DEL_6_75504) Is a Susceptibility Factor for Cryptorchidism and Hypospadias. (2023) (0)
Evaluation of a Strabismus Susceptibility Locus on Chromosome 7p in Japanese (2005) (0)
[ix-layer structure for genomics:A powerful conceptual framework that integrates research, test and treatment]. (2016) (0)
Purine and Pyrimidine Metabolism (2021) (0)
Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan (2014) (0)
Two Cases Suggesting Idiopathic Intercostal Neuralgia (1991) (0)
peripheral blood T cell culture using T cell growth factor A new method for the detection of Lesch-Nyhan heterozygotes by (2011) (0)
[Expression and genetic alteration of HGPRT gene: basic and clinical aspects]. (1985) (0)
A schematic construct of the promoterless pGL3-basic vector (2011) (0)
[Theory for identification of disease-related genes using genetic polymorphisms]. (2002) (0)
[Physiopathological interpretation and progress in diagnosis and treatment. 2) Gout and pseudogout]. (2000) (0)
A mechanism of IL-17 action in the rheumatoid arthritis (2001) (0)
Kremezin as an alternative strategy to reduce the temporal increase of serum uric acids (2005) (0)
434 Four loci at 11q12, 10q26, 3p11.2, and 2p11 are associated with prostate cancer susceptibility in the Japanese population (2012) (0)
Divergent effects ofmethotrexate on theclonal growth ofT andBlymphocytes andsynovial adherent cells frompatients withrheumatoid arthritis (1996) (0)
[Genetic testing and gene-based testing for hyperuricemia and gout]. (2005) (0)
The association between myocardial infarction and the severity of gouty arthritis in Taiwan (2004) (0)
Unified method for Bayesian calculation of genetic risk (2006) (0)
Corrections to "Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population" (2005) (0)
[Diagnosis and treatment of hyperuricemia and gout]. (2007) (0)
[A questionnaire-based survey on the Internet concerning optimal timing for knee surgery in a patient with rheumatoid arthritis]. (2001) (0)
Diagnosis of Lesch-Nyhan heterozygotes by peripheral blood. (1986) (0)
Endoscopic ultrasonograms in patients with Behçet's colitis (2004) (0)
Ligand Superfamily-13 B Stimulator / B Cell-Activating Factor / TNF Contribution to Induction of B Lymphocyte with Systemic Lupus Erythematosus and Its in Patients γ Excessive Production of IFN - (2008) (0)
[Gene diagnosis and gene therapy]. (1993) (0)
[Adenine phosphoribosyltransferase deficiency]. (1993) (0)
Observational Cohort The Influence of Sex on Patients with Rheumatoid Arthritis in a Large (2009) (0)
52 DIVERGENT EFFECTS OF BREDININ ON HUMAN T CELL SUBSETS (1988) (0)
Investigation of the origin of hypoxanthine guanine phosphoribosyltransferase( HPRT1)mutation using mitochondrial DNA polymorphisms. (2002) (0)
Drug delivery system. Enzyme supplementation therapy for genetic enzyme deficiencies. (1989) (0)
of Polymyositis and Dermatomyositis: Role Increased CD40 Expression on Muscle Cells (2013) (0)
Lack of Association between Anti-Ribosomal-P Antibody and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus (2008) (0)
Properties and activities of phosphoribomutase in human leukemic cells. (1984) (0)
Troglitazone decreases serum uric acid concentration in type 2 diabetic patients (2000) (0)
Prevalence of Type A behavior pattern among Japanese patients with nrimary gont (1999) (0)
Comparison of surface differentiation antigens between HGPRT-positive and negative T-cells from two Lesch-Nyhan heterozygotes. (1986) (0)
Unsolved problems concerning gout and nucleic acid metabolism (2016) (0)
Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments (2017) (0)
Treatment of gout and hyperuricemia, an update (2014) (0)
[Definition of hyperuricemia and methods for serum urate determination]. (1991) (0)
[AMP deaminase deficiency]. (1998) (0)
Abstract 4727: Breast cancer prevention and selective estrogen response modulators (SERMs): Pharmacogenomics and differential estrogen and SERM regulation of BRCA1 and BRCA2 expression (2011) (0)
Association between hypoxanthine concentration in synovial fluid and joint destruction in patients with rheumatoid arthritis (1998) (0)
Benefits of serum uric acid in reducing the suscepibility to acute arthritis during the treatment of gout (1993) (0)
FACTORS ASSOCIATED WITH RENAL INSUFFICIENCY IN TAIWANESE GOUT (2006) (0)
Budd-Chiari syndrome associated with primary antiphospholipid syndrome. (2002) (0)
ヒトが高尿酸血症を呈するようになった理由の新たな説明 (2018) (0)
A rapidly mixing approximate sampler of Dirichlet distribution (2003) (0)
High-performance liquid chromatographic method for simultaneous screening of the deficiencies of APRT and HPRT. (1989) (0)
DIAGNOSIS OF LESCH-NYHAN HETEROZYGOTES USING PERIPHERAL BLOOD: 97 (1985) (0)
2-COROADENOSINE IS PHOSPHORYLATED AND INCREASES THE PRODUCTION OF HYPOXANTHINE IN HUMAN CELLLS: 234 (1985) (0)
A MutantAllele CommontotheTypeIAdenine Phosphoribosyltransferase Deficiency inJapanese Subjects (1991) (0)
VII. Genome and Medical Administration System (2016) (0)
rheumatoid arthritis promoter polymorphism with FCRL 3 of the Supportive evidence for a genetic association (2005) (0)
[Familial juvenile gouty nephropathy]. (1998) (0)
Roles of osteoblasts, osteoclasts, T cells and cytokines in glucocorticoid-induced osteoporosis (2007) (0)
[Tailor-made medicine and genomic drug discovery in rheumatoid arthritis]. (2005) (0)
70 EVIDENCE AND EXPLANATION FOR THE PRESENCE OF A COMMON ANCESTOR DISEASE-CAUSING GENE FOR THE JAPANESE-TYPE APRT DEFICIENCY (1988) (0)
[The Framework for Clinical Practice : Current Trends. Topics : VII. Genome and medical administration system]. (2016) (0)
Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs (2018) (0)
Are minor alleles more likely to be risk alleles? (2018) (0)
[Molecular mechanism of bone metabolism]. (2000) (0)
20 CLINICAL ASPECTS OF GOUTY PATIENTS IN TAIWAN (1988) (0)
OE-009 Identification of a Locus on Chromosome 5p that Confers Risk of Coronary Artery Disease by Genome Wide Association Study(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society) (2009) (0)
97 High-Performance Liquid Chromatographic method for Simultaneous Screening of the Deficiencies of APRT and HGPRT (1988) (0)
Pharmacogenomics in the treatment of rheumatoid arthritis: clinical implication and perspective. (2006) (0)
A Threshold of Disequilibrium Parameters to Identify Haplotype Blocks on Biallelic Models (2007) (0)
Genes, the brain, and artificial intelligence in evolution (2020) (0)
[Physiopathology and treatment of gout and hyperuricemia]. (1999) (0)
Promoter activity of A/G at position -168 in the type III promoter of MHCIITA gene. (2007) (0)
ALLELE FREQUENCIES OF TWO NONSYNONYMOUS POLYMORPHISMS IN THE CDA GENE IN FIVE POPULATIONS (2009) (0)
[Efficacy of in travenous cyclophosphamide therapy on rheumatic diseases]. (2002) (0)
Deletion in the hypoxanthine phosphoribosyltransferase gene caused by Alu-Alu recombination in two Japanese patients with Lesch-Nyhan syndrome. (2000) (0)
[Crohn's disease presenting arthritis of knees without any gastrointestinal symptoms]. (2003) (0)
Mutant T Cells Deficient in Hypoxanthine Phosphoribosyltransferase (HPRT) Are Not Selected Against In Vivo (1995) (0)
[Pharmacogenomics of the immunosuppressive agents]. (2002) (0)
Apolipoprotein D modulates lipid mediators and osteopontin in an anti-inflammatory direction (2022) (0)
Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP (2019) (0)
A first evidence of an asymptomatic germline missense base substitution in the hypoxanthine phosphoribosyltransferase (HPRT) gene in humans. (1998) (0)
[Three families with 2,8-dihydroxyadenine urolithiasis having different genetic abnormalities]. (1986) (0)
A germline partial deletion of adenine phosphoribosyltransferase gene presumably related to the suppression of loss of heterozygosity in somatic cells (1997) (0)
[Prospective cohort studies of incident fractures in patients with rheumatoid arthritis]. (2007) (0)
[Topics on eosinophilia-myalgia syndrome]. (1991) (0)
Abstract 11738: A Genome-wide Association Analysis Identifies PDE1ADNAJC10 Locus on Chromosome 2 Associated With Idiopathic Pulmonary Arterial Hypertension in the Japanese Population (2015) (0)
Search for the mechanisms of high incidence of APRT deficiency among Japanese. (1994) (0)
The origin of the most common mutation of adenine phosphoribosyltransferase deficiency among Japanese goes back to a prehistoric era (1997) (0)
ヒポキサンチンホスホリボシルトランスフェラーゼ（Hprt）高活性キサンチンデヒドロゲナーゼ（Xdh）ノックアウトマウスの作出 (2018) (0)
Identification of a nonsense mutation in the xanthine dehydrogenase gene in two separate families with hereditary xanthinuria (1997) (0)
Influence of Inflammation on Lipid Metabolism in the Patients with Rheumatoid Arthritis (2004) (0)
294 LACK OF ASSOCIATION OF SINGLE-NUCLEOTIDE POLYMORPHISM IN LRCH1WITH KNEE OSTEOARTHRITIS SUSCEPTIBILITY (2007) (0)
THE ASSOCIATION BETWEEN HYPERTENSION AND THE SEVERITY OF GOUTY ARTHRITIS IN TAIWAN (2009) (0)
Quantification of PAP39 and PRS1 mRNA by competitive PCR (1997) (0)
[Progress in the study of allergy and collagen disease in the last 100 years: Gout]. (2002) (0)
[Adenine phosphoribosyltransferase deficiency]. (1988) (0)
[A case of pseudolymphoma originating in the thymic region]. (1985) (0)
Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region (2018) (0)
[Future directions of pharmacogenomics (PGx)]. (2011) (0)
エネルギー代謝から見たXOR（XDH/XO）の臓器間局在性とプリンサルベージ回路の重要性についての仮説 (2018) (0)
List of Contributors (2021) (0)
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations (2018) (0)
Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese patients. (2012) (0)
Relation between Genetics and Statistics (2005) (0)
Procede d'analyse d'haplotype (2004) (0)
PMS51 MAJOR DETERMINANTS OF EUROQOL (EQ-5D) IN PATIENTS WITH RHEUMATOID ARTHRITIS BASED ON A LARGE JAPANESE COHORT IORRA (2008) (0)

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