Natasha J. Caplen

Natasha J. Caplen's AcademicInfluence.com Rankings

Natasha J. Caplen

Biology

#14303

World Rank

#18019

Historical Rank

Genetics

#1674

World Rank

#1782

Historical Rank

biology Degrees

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Biology

Why Is Natasha J. Caplen Influential?

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According to Wikipedia, Natasha Jane Caplen is a British-American geneticist who discovered RNA interference in mammalian cells. She is a senior investigator and head of the functional genetics section at the National Cancer Institute.

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Natasha J. Caplen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. (2006) (3121)
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems (2001) (1089)
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis (1995) (677)
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells (2004) (614)
dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference. (2000) (244)
RNAi microarray analysis in cultured mammalian cells. (2003) (200)
p53-dependent Induction of PVT1 and miR-1204* (2011) (178)
The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24 (2008) (176)
Defining and assaying RNAi in mammalian cells. (2005) (167)
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. (2006) (156)
Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton1 (2005) (152)
Applications of RNA interference in mammalian systems. (2007) (146)
The 8q24 Gene Desert: An Oasis of Non-Coding Transcriptional Activity (2012) (138)
Gene Therapy Progress and Prospects. Downregulating gene expression: the impact of RNA interference (2004) (125)
Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response* (2009) (121)
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. (2002) (119)
Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes (2008) (113)
Pvt1-encoded microRNAs in oncogenesis (2008) (109)
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA (2011) (108)
Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide] (2009) (94)
Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference. (2002) (92)
Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome (2010) (91)
MicroRNAs and genomic instability. (2007) (89)
Asparagine synthetase as a causal, predictive biomarker for l-asparaginase activity in ovarian cancer cells (2006) (87)
Short Interfering RNA (siRNA)—Mediated RNA Interference (RNAi) in Human Cells (2003) (85)
MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival (2019) (83)
Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. (2013) (73)
RNAi as a gene therapy approach (2003) (70)
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo (2006) (65)
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells (2012) (52)
Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation. (2013) (50)
Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins (2014) (49)
A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets (2011) (47)
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies (2008) (45)
Adeno-retroviral chimeric viruses as in vivo transducing agents (1999) (44)
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. (2011) (42)
EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis (2018) (39)
Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma. (2016) (34)
Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions. (2005) (34)
Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines (2014) (34)
A new approach to the inhibition of gene expression. (2002) (33)
Localization and up‐regulation of Mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis (1997) (32)
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening (2014) (29)
Mismatched siRNAs downregulate mRNAs as a function of target site location (2006) (29)
Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer (2012) (28)
Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors. (1998) (28)
Multiplexing siRNAs to compress RNAi-based screen size in human cells (2007) (27)
Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus (2004) (24)
Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells (2014) (22)
HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction (2019) (20)
Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity. (2014) (20)
Fusion transcripts: Unexploited vulnerabilities in cancer? (2019) (17)
In situ generation of pseudotyped retroviral progeny by adenovirus‐mediated transduction of tumor cells enhances the killing effect of HSV‐tk suicide gene therapy in vitro and in vivo (2004) (17)
Allele‐specific silencing of the dominant disease allele in sialuria by RNA interference (2008) (15)
BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). (2017) (13)
CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma (2020) (12)
Cystic fibrosis gene therapy trials and tribulations. (2001) (12)
BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1) (2017) (10)
Genomic instability and mouse microRNAs (2011) (8)
Nucleic acid transfer using cationic lipids. (2000) (8)
Gene silencing through RNA interference: Potential for therapeutics and functional genomics (2003) (8)
Identification of therapeutic targets applicable to clinical strategies in ovarian cancer (2016) (6)
Abstract 15: gp78 is a negative regulator of TRAIL-induced apoptosis in breast cancer cells (2015) (6)
Gene therapy: different strategies for different applications (1998) (6)
RNAi quashes polyQ (2004) (6)
Cancer biology functional genomics: From small RNAs to big dreams (2020) (4)
Abstract #4664: Implication of ATM-/ATR-Chk1-E2F1-dependent up-regulation of ribonucleotide reductase R2 (RRM2) in DNA damage response (2009) (4)
Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma (2022) (3)
‘Forkhead’ gene expression balanced on a knife-edge (2001) (3)
Abstract A120: Cellular inhibition of Chk2 kinase and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 (2009) (3)
Gene therapy: different strategies for different applications. American Society of Gene Therapy: First Annual Meeting, Seattle, Washington, USA, 28-31 May 1998. (1998) (3)
Applications of RNA Interference in Mammalian (2007) (3)
Gene therapy for neurodegeneration (2001) (2)
Amplified genes as therapeutic targets in cancer (2003) (2)
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of traditional cytotoxic agents in breast cancer cells. (2007) (2)
Gene Silencing through RNA Interference (2006) (2)
Cystic Fibrosis: Gene Therapy Approaches (2001) (2)
Lentiviral vectors: Aids for gene therapy (1998) (1)
Cellular inhibition of Chk 2 kinase and potentiation of camptothecins and radiation by the novel Chk 2 inhibitor PV 1019 (2009) (1)
Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019 (2009) (1)
HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript (2022) (1)
Is successful gene therapy for retinal disease in sight? (2000) (1)
Gene Silencing by RNA Interference and the Role of Small Interfering RNAs (2004) (1)
LacZ siRNA and antisense DNA decrease beta-galactosidase mRNA but not protein expression in the airways of K18-lacZ transgenic mice (2004) (1)
Abstract 1952: The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24 (2010) (1)
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening (2014) (1)
Inhibition of PLK1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitization (2013) (1)
Interactive Clustered Heat Map Builder: An easy web-based tool (2020) (1)
Mirome Architecture and Genomic Instability (2019) (1)
Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer (2012) (1)
High-throughput RNAi screening identifies sensitizing targets to improve doxorubicin chemotherapy (2004) (1)
Sickle cell gene therapy (2002) (1)
Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma (2015) (0)
Regulation of c-FLIP Prevents Tumor Necrosis Factor – Alpha (TNF-a) Induced Programmed Cell Death in Human Retinal Pigment Epithelium (hRPE) (2003) (0)
Integrated analysis of RNAi screens in pediatric rhabdomyosarcoma. (2013) (0)
Abstract A105: A small RNA interference screen of genes involved in DNA repair identifies genes mediating radiosensitivity in glioblastoma. (2011) (0)
Gene silencing through RNA interference and antisense strategies in the lung (2003) (0)
Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition (2018) (0)
From identification of therapeutic targets to clinical strategies (2016) (0)
Abstract A117: Chk1‐dependent up‐regulation of ribonucleotide reductase R2 in response to camptothecin‐induced DNA damage (2009) (0)
A valiant effort (1999) (0)
Abstract 267: Large-scale RNAi screening of human kinome identifies putative breast cancer related molecular targets (2012) (0)
Abstract 4106: A functional genomic approach to identify novel molecular regulators of the TRAIL pathway in breast cancer (2011) (0)
Gene therapy for HIV infection: safe if not efficacious (1999) (0)
Abstract #1991: Validation of novel colorectal cancer genes as potential therapeutic targets using functional genomics approaches (2009) (0)
Abstract LB-74: A high-throughput RNAi sensitization screen of rapamycin identifies targets for rational drug combination strategies (2010) (0)
Book reviews (1997) (0)
Gene transfer to liver (1999) (0)
Inhibition specifique d'expression de gene par de petits arns double brin (2002) (0)
A fhit-ing end to tumor development (2001) (0)
Abstract IA04: Targeting the expression of EWS-FLI1 (2018) (0)
Lipid Gene Trasfer, a Story of Simplicity and Complexity (1998) (0)
GENE THERAPY FOR RESPIRATORY DISEASE (1998) (0)
Identification of TNK2 as a critical kinase in rhabdomyosarcoma through a loss of function shRNA screen. (2012) (0)
Abstract A198: Identification and preclinical testing of novel targeted therapies for human triple-negative breast cancer. (2011) (0)
Identification and functional validation of potential target genes in colorectal cancers (2009) (0)
Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines (2014) (0)
Hemophilia gene therapy: better than we hoped for? (2000) (0)
Abstract 247: A functional genomics and a systems biology approach identify POMP as a potential therapeutic target for colorectal cancer (2010) (0)
TP53 on trial for cancer gene therapy (1998) (0)
Histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability. (2023) (0)
Application of Microarray Technologies for Translational Genomics (2005) (0)
Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells. (2013) (0)
Use of predictive gene expression signature from advanced-stage serous papillary ovarian cancer to identify biologically relevant molecular targets for chemoresponse (2007) (0)
Actin Cytoskeleton TCR-Induced Regulation of Vav and the Kinase-Independent Functions for Itk in (2005) (0)
Human alpha 1-antitrypsin gene transfer with cationic liposomes in vitro and in vivo (1996) (0)
Abstract 1683: ATF4 down-regulation potentiates L-asparaginase activity in ovarian cancer cell lines (2010) (0)
Asparagine synthetase is a biomarker of L-asparaginase activity in multiple cancer cell types (2008) (0)
Identification of therapeutic targets applicable to clinical strategies in ovarian cancer (2016) (0)
Structural insights into adenoviral fiber protein (2000) (0)
Abstract B012: Visualization of EWSR1’s colocalization with phosphorylated RNA-Polymerase II reveals its concentration at a subset of active regions of transcription in ewing sarcoma cells (2022) (0)
Abstract 199: Noncoding RNAs of the 8q24 locus (2012) (0)
Abstract 4408: A functional genomics approach for identification of sirolimus sensitizer genes regulated by HDAC inhibitors. (2013) (0)
Abstract 5471: EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis (2018) (0)
Gene therapy under pressure (1999) (0)
The HNRNPF/H RNA binding proteins and disease. (2023) (0)
ABCG2: A biomarker for the early stages of multidrug resistance in cancer cells (2007) (0)
Mending mutations by in vivo site-directed mutagenesis (1998) (0)
HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript. (2022) (0)
Abstract LB-87: Analysis of JAZF1 loss-of-function reveals its role in regulation of genes relevant for prostate cancer (2014) (0)
Lipid Gene Transfer and Clinical Gene Therapy (1998) (0)
Abstract 5124: Identification and characterization of novel regulators of TRAIL-induced apoptosis in breast cancer cells (2014) (0)
Abstract 1834: Noncoding RNAs of the 8q24 locus: Consequences of the over-expression or suppression of miR-1204 and PVT1 in developing B cells. (2013) (0)
Abstract C111: Genes cooperatively targeted by combined mTOR/histone deactylase (HDAC) inhibition are predictive of increased multiple myeloma patient survival. (2011) (0)
RNAi Screen Reveals Candidate miRNAs Associated with the NF‐κB Pathway (2013) (0)
Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1 (2014) (0)
High-throughput RNAi screening identifies sensitizing targets to improve doxorubicin chemotherapy. (2004) (0)
Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction (2020) (0)
Abstract 2041: Large-scale RNAi screening identifies PCTK3/CDK18 as a putative cancer-related molecular target (2011) (0)
Abstract 96: From genome-wide association studies (GWAS) to functional genomics of prostate cancer: exploring the role of candidate transcripts through RNAi-based analysis (2012) (0)
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells (2012) (0)
Abstract 1181: Expression studies from the PVT1 region of 8q24 (2011) (0)
Abstract 2098: The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA (2010) (0)
Abstract 3204: The identification of AURKB, BUB1B and CDK18 as putative molecular targets for breast cancer using kinome focused RNAi screens. (2013) (0)
551 POSTER RNAi-based identification of potential targets in colorectal cancers (2008) (0)
Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1 (2016) (0)
Abstract C222: The identification of kinase targets in Ewing sarcoma cell lines using RNAi and high-throughput investigational agents screens. (2013) (0)
Abstract B25: An unbiased functional screen identifies kinases essential to ovarian cancer cell survival (2013) (0)

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Other Resources About Natasha J. Caplen

en.wikipedia.org

What Schools Are Affiliated With Natasha J. Caplen?

Natasha J. Caplen is affiliated with the following schools:

University of Oxford
Stanford University
Harvard University