Neil Kelleher
#76,336
Most Influential Person Now
American chemist
Neil Kelleher 's AcademicInfluence.com Rankings
Neil Kelleher chemistry Degrees
Chemistry
#1236
World Rank
#1910
Historical Rank
#485
USA Rank
Analytical Chemistry
#30
World Rank
#35
Historical Rank
#12
USA Rank
Physical Chemistry
#241
World Rank
#281
Historical Rank
#71
USA Rank
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Chemistry
Neil Kelleher 's Degrees
- PhD Chemistry University of California, Berkeley
Why Is Neil Kelleher Influential?
(Suggest an Edit or Addition)According to Wikipedia, Neil L. Kelleher is the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine at Northwestern University. His research focuses on mass spectrometry, primarily its application to proteomics. He is known mainly for top-down proteomics and the development of the fragmentation technique of electron-capture dissociation with Roman Zubarev while in Fred McLafferty's lab at Cornell University.
Neil Kelleher 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process (1998) (1614)
- Proteoform: a single term describing protein complexity (2013) (1039)
- Electron capture dissociation for structural characterization of multiply charged protein cations. (2000) (834)
- EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. (2013) (689)
- Mapping Intact Protein Isoforms in Discovery Mode Using Top Down Proteomics (2011) (583)
- Top down versus bottom up protein characterization by tandem high- resolution mass spectrometry (1999) (503)
- Decoding protein modifications using top-down mass spectrometry (2007) (448)
- How many human proteoforms are there? (2018) (440)
- Precision proteomics: The case for high resolution and high mass accuracy (2008) (413)
- Top Down proteomics: facts and perspectives. (2014) (383)
- Peer Reviewed: Top-Down Proteomics (2004) (372)
- A Roadmap for Natural Product Discovery Based on Large-Scale Genomics and Metabolomics (2014) (371)
- Progress in Top-Down Proteomics and the Analysis of Proteoforms. (2016) (366)
- A computational framework to explore large-scale biosynthetic diversity (2019) (342)
- A monovalent streptavidin with a single femtomolar biotin binding site (2006) (341)
- Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. (2005) (337)
- Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid. (1999) (335)
- The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. (2011) (323)
- Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas (2017) (294)
- Certain and Progressive Methylation of Histone H4 at Lysine 20 during the Cell Cycle (2007) (277)
- Loss of BAP1 function leads to EZH2-dependent transformation (2015) (275)
- Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry (1996) (272)
- Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. (2013) (264)
- Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic (2006) (229)
- Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity (2004) (227)
- Pervasive combinatorial modification of histone H3 in human cells (2007) (225)
- ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry (2007) (216)
- Negative regulation of NF‐κB action by Set9‐mediated lysine methylation of the RelA subunit (2009) (208)
- Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. (2006) (208)
- Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids (2015) (206)
- Top down proteomics. (2013) (201)
- Deconstruction of Iterative Multidomain Polyketide Synthase Function (2008) (192)
- GASEOUS CONFORMATIONAL STRUCTURES OF CYTOCHROME C (1998) (192)
- ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry (2004) (183)
- Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation (2014) (183)
- Mass spectrometric characterization of human histone H3: a bird's eye view. (2006) (183)
- Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases. (1996) (174)
- Combinatorial Modification of Human Histone H4 Quantitated by Two-dimensional Liquid Chromatography Coupled with Top Down Mass Spectrometry* (2008) (173)
- ProSight Lite: Graphical software to analyze top‐down mass spectrometry data (2015) (172)
- Informatics and multiplexing of intact protein identification in bacteria and the archaea (2001) (172)
- Attomole-sensitivity electrospray source for large-molecule mass spectrometry. (1995) (168)
- Best practices and benchmarks for intact protein analysis for top-down mass spectrometry (2019) (161)
- On the scalability and requirements of whole protein mass spectrometry. (2011) (158)
- Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. (2005) (154)
- Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. (2006) (150)
- Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (2006) (148)
- Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability (2017) (146)
- Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids (2018) (146)
- Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20* (2008) (144)
- Proteoforms as the next proteomics currency (2018) (144)
- Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. (2002) (139)
- Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. (2006) (138)
- Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. (2004) (138)
- Rapid Sequencing of Oligonucleotides by High-Resolution Mass Spectrometry (1994) (135)
- Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. (1999) (135)
- The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer (2012) (132)
- Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS* (2012) (131)
- Cell-free Protein Synthesis from a Release Factor 1 Deficient Escherichia coli Activates Efficient and Multiple Site-specific Nonstandard Amino Acid Incorporation (2013) (131)
- From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry. (2013) (130)
- Detection and localization of protein modifications by high resolution tandem mass spectrometry. (2005) (127)
- A Proteomics Approach to Discovery of Natural Products and Their Biosynthetic Pathways (2009) (124)
- A Scalable Platform to Identify Fungal Secondary Metabolites and Their Gene Clusters (2017) (122)
- Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. (2007) (120)
- Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. (2006) (119)
- Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies (2014) (117)
- Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. (2005) (117)
- A Protease for Middle Down Proteomics (2012) (117)
- Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence* (2013) (116)
- Thiamin Biosynthesis in Escherichia coli (1998) (116)
- Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. (2005) (116)
- Web and database software for identification of intact proteins using "top down" mass spectrometry. (2003) (115)
- Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis (2003) (114)
- Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence (2017) (114)
- Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3 (2012) (114)
- Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units (2006) (109)
- The emerging landscape of single-molecule protein sequencing technologies (2021) (107)
- Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain (2017) (107)
- Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. (2007) (107)
- Mass spectrometry-based discovery of circadian peptides (2008) (106)
- Analysis of Intact Protein Isoforms by Mass Spectrometry* (2011) (105)
- Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites (2013) (103)
- 193 nm photodissociation of larger multiply-charged biomolecules (1996) (101)
- Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II (2010) (101)
- Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo. (2011) (100)
- Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture (2020) (98)
- Precise and Parallel Characterization of Coding Polymorphisms, Alternative Splicing, and Modifications in Human Proteins by Mass Spectrometry*S (2005) (97)
- Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. (2006) (97)
- Gene-specific characterization of human histone H2B by electron capture dissociation. (2006) (97)
- Identification and Quantification of Proteoforms by Mass Spectrometry (2019) (96)
- A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome (2009) (96)
- The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput. (2010) (95)
- Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. (2004) (94)
- Construction of a hybrid quadrupole/fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa (2004) (93)
- Top-down characterization of endogenous protein complexes with native proteomics (2017) (93)
- The emergence of top-down proteomics in clinical research (2013) (92)
- Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. (2010) (88)
- The first pilot project of the consortium for top‐down proteomics: A status report (2014) (86)
- Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. (2012) (86)
- UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition. (2017) (84)
- Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. (1999) (84)
- Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer (2016) (84)
- Global Assessment of Combinatorial Post-translational Modification of Core Histones in Yeast Using Contemporary Mass Spectrometry (2007) (84)
- Kinetic and Mass Spectrometric Analysis of p300 Histone Acetyltransferase Domain Autoacetylation* (2006) (83)
- Efficient sequence analysis of the six gene products (7‐74 kDA) from the escherichia coli thiamin biosynthetic operon by tandem high‐resolution mass spectrometry (1998) (83)
- Unit resolution mass spectra of 112 kDa molecules with 3 Da accuracy (1997) (82)
- Applying Label-Free Quantitation to Top Down Proteomics (2014) (80)
- Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques. (2018) (79)
- Endogenous Peptide Discovery of the Rat Circadian Clock (2009) (79)
- Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging (2021) (78)
- Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa. (2016) (78)
- Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics. (2013) (78)
- Multiplexed Mass Spectrometry of Individual Ions Improves Measurement of Proteoforms and Their Complexes (2020) (77)
- Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. (2005) (77)
- Improving Cell‐Free Protein Synthesis through Genome Engineering of Escherichia coli Lacking Release Factor 1 (2015) (77)
- Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. (2011) (76)
- The biosynthesis of methanobactin (2018) (76)
- Electron capture versus energetic dissociation of protein ions 1 1 Dedicated to the memory of Profes (1999) (75)
- Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N2 Reduction. (2019) (75)
- In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis. (2017) (74)
- Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein. (2017) (73)
- Ultraviolet Photodissociation for Characterization of Whole Proteins on a Chromatographic Time Scale (2014) (72)
- New and automated MSn approaches for top-down identification of modified proteins (2005) (72)
- Interpreting top-down mass spectra using spectral alignment. (2008) (71)
- Optimizing capillary electrophoresis for top‐down proteomics of 30–80 kDa proteins (2014) (71)
- Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry. (2006) (71)
- Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation. (2015) (70)
- Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. (2020) (69)
- Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. (2008) (69)
- Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality. (1999) (68)
- A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis (2008) (68)
- Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. (2007) (68)
- Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry. (2017) (67)
- Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval. (2009) (66)
- Kinetics of Re-establishing H3K79 Methylation Marks in Global Human Chromatin* (2010) (66)
- The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity. (2007) (65)
- The C-Score: A Bayesian Framework to Sharply Improve Proteoform Scoring in High-Throughput Top Down Proteomics (2014) (65)
- Tissue-specific expression and post-translational modification of histone H3 variants. (2008) (65)
- High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer. (2017) (64)
- Top down proteomics of human membrane proteins from enriched mitochondrial fractions. (2013) (63)
- Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. (2011) (63)
- Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases. (2006) (63)
- Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2. (2017) (62)
- Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. (2012) (62)
- Comprehensive Phosphoprotein Analysis of Linker Histone H1 from Tetrahymena thermophila*S (2006) (62)
- Neuropeptidomics of the Supraoptic Rat Nucleus (2008) (62)
- Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics. (2004) (61)
- Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts* (2015) (61)
- Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk (2018) (61)
- Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. (2006) (59)
- Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer. (2017) (59)
- Fungal artificial chromosomes for mining of the fungal secondary metabolome (2015) (59)
- USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia (2018) (59)
- Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. (2005) (58)
- Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. (2007) (58)
- A community resource for paired genomic and metabolomic data mining (2021) (58)
- "Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. (2008) (58)
- tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics (2011) (57)
- Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. (2015) (57)
- Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. (2006) (57)
- Mild Performic Acid Oxidation Enhances Chromatographic and Top Down Mass Spectrometric Analyses of Histones*S (2007) (56)
- An informatic framework for decoding protein complexes by top-down mass spectrometry (2015) (56)
- Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. (2005) (55)
- Top Down Mass Spectrometry of <60-kDa Proteins from Methanosarcina acetivorans Using Quadrupole FTMS with Automated Octopole Collisionally Activated Dissociation*S (2006) (55)
- Redox Metabolites Signal Polymicrobial Biofilm Development via the NapA Oxidative Stress Cascade in Aspergillus (2015) (54)
- Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. (2006) (54)
- Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein (2006) (54)
- In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. (1999) (53)
- Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis. (2008) (53)
- Intact mass detection, interpretation, and visualization to automate Top‐Down proteomics on a large scale (2010) (52)
- Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo. (2011) (52)
- The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. (2006) (51)
- Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 (2016) (51)
- Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus. (2013) (51)
- The Human Proteoform Project: Defining the human proteome (2021) (51)
- A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data (2018) (50)
- Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase (2019) (50)
- Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry. (2016) (50)
- Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. (2011) (50)
- A Cell-Based Approach to the Human Proteome Project (2012) (50)
- ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. (1998) (50)
- Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry (2009) (50)
- A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli. (2019) (49)
- A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation (2017) (49)
- Biosynthesis of the β-Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring β-Amino Acyl-S-carrier Protein Intermediates (2005) (49)
- Proteomics-based discovery of koranimine, a cyclic imine natural product. (2011) (49)
- Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. (2006) (48)
- A comprehensive pipeline for translational top-down proteomics from a single blood draw (2018) (48)
- Translation system engineering in Escherichia coli enhances non‐canonical amino acid incorporation into proteins (2017) (47)
- Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics* (2016) (47)
- Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas (2019) (47)
- An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes (2020) (47)
- Toward efficient analysis of <70 kDa proteins with 100% sequence coverage (2001) (46)
- Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression* (2015) (45)
- Separation of variant methylated histone tails by differential ion mobility. (2012) (45)
- A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. (2012) (44)
- Ion mobility separation of variant histone tails extending to the "middle-down" range. (2012) (44)
- Mechanistic Studies on Thiaminase I (1996) (44)
- Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data. (2007) (43)
- Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. (2013) (43)
- A selective chemical probe for coenzyme A-requiring enzymes. (2007) (43)
- Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring (2017) (42)
- Modern mass spectrometry for synthetic biology and structure-based discovery of natural products. (2016) (42)
- A Mutation in Histone H2B Represents a New Class of Oncogenic Driver. (2019) (41)
- Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. (2012) (41)
- In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. (2009) (41)
- Overexpression of recombinant proteins with a C‐terminal thiocarboxylate: Implications for protein semisynthesis and thiamin biosynthesis (1998) (40)
- Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins. (2019) (40)
- Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. (2004) (40)
- Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation (2016) (40)
- Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. (2007) (40)
- Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. (2020) (39)
- Top-down proteomics: Where we are, where we are going? (2017) (39)
- Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa. (2012) (39)
- NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle (2020) (38)
- Top-down proteomics reveals novel protein forms expressed in methanosarcina acetivorans (2009) (38)
- Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry (2017) (38)
- A five-level classification system for proteoform identifications (2019) (38)
- Characterization of neurohistone variants and post-translational modifications by electron capture dissociation mass spectrometry (2007) (38)
- Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. (2008) (36)
- Top-Down Proteomics with Mass Spectrometry Imaging: A Pilot Study towards Discovery of Biomarkers for Neurodevelopmental Disorders (2014) (36)
- Characterization of proteomic and metabolomic responses to dietary factors and supplements. (2007) (36)
- Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria (2018) (36)
- Native GELFrEE: a new separation technique for biomolecular assemblies. (2015) (35)
- Thiaminase I (42 kDa) heterogeneity, sequence refinement, and active site location from high-resolution tandem mass spectrometry (1995) (35)
- Illuminating the dark matter of shotgun proteomics (2015) (35)
- New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans. (2016) (34)
- An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia (2018) (34)
- A researcher's guide to mass spectrometry‐based proteomics (2016) (34)
- Comparing Label-Free Quantitative Peptidomics Approaches to Characterize Diurnal Variation of Peptides in the Rat Suprachiasmatic Nucleus (2013) (33)
- Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. (2016) (33)
- Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. (1998) (33)
- ProForma: A Standard Proteoform Notation. (2018) (33)
- Proton transfer charge reduction enables high-throughput top-down analysis of large proteoforms. (2019) (32)
- Deep and quantitative top-down proteomics in clinical and translational research (2014) (32)
- Deciphering the late biosynthetic steps of antimalarial compound FR-900098. (2010) (32)
- The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. (2010) (32)
- High-definition De Novo Sequencing of Crustacean Hyperglycemic Hormone (CHH)-family Neuropeptides* (2012) (31)
- Analyzing Internal Fragmentation of Electrosprayed Ubiquitin Ions During Beam-Type Collisional Dissociation (2015) (31)
- Direct sequence data from heterogeneous creatine kinase (43 kDa) by high-resolution tandem mass spectrometry. (1995) (31)
- A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth (2008) (31)
- Accessing natural product biosynthetic processes by mass spectrometry. (2008) (31)
- Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics. (2018) (31)
- Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways (2014) (30)
- Bone protein “extractomics”: comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics (2016) (30)
- Fourier‐transform mass spectrometry for automated fragmentation and identification of 5‐20 kDa proteins in mixtures (2002) (30)
- Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. (2007) (30)
- Autopilot: An Online Data Acquisition Control System for the Enhanced High-Throughput Characterization of Intact Proteins (2014) (30)
- Chromatin occupancy and epigenetic analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis. (2019) (29)
- Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. (2003) (29)
- Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients (2017) (29)
- SPT5 stabilization of promoter-proximal RNA polymerase II. (2021) (29)
- In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research. (2020) (29)
- Substrate Specificity of the Adenylation Enzyme SgcC1 Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027* (2006) (29)
- The dehydratase activity of lacticin 481 synthetase is highly processive. (2006) (29)
- Erratum: Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization (Chemistry and Biology (1999) 6 (385-400)) (1999) (29)
- Site‐specific human histone H3 methylation stability: fast K4me3 turnover (2014) (28)
- Miniaturized formats for efficient mass spectrometry-based proteomics and therapeutic development. (2002) (28)
- Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine (2012) (28)
- Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics. (2013) (28)
- Identification of Modification Sites in Large Biomolecules by Stable Isotope Labeling and Tandem High Resolution Mass Spectrometry (1997) (28)
- Characterization of Methanobactin from Methylosinus sp. LW4. (2016) (28)
- A Method for Label-Free, Differential Top-Down Proteomics. (2016) (28)
- The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing (2020) (27)
- Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite. (2016) (27)
- Natural products from thioester reductase containing biosynthetic pathways. (2018) (27)
- Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica. (2006) (27)
- A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity. (2018) (26)
- The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. (2018) (26)
- From primary structure to function: biological insights from large-molecule mass spectra. (2000) (26)
- Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra. (2008) (26)
- Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange. (2003) (26)
- Accurate base composition of double-strand DNA by mass spectrometry (1996) (26)
- Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase. (2013) (26)
- Standard Proteoforms and Their Complexes for Native Mass Spectrometry (2019) (26)
- The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells (2022) (26)
- Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools. (2017) (25)
- Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method. (2015) (25)
- Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. (2004) (25)
- Two-dimensional mass spectrometry of biomolecules at the subfemtomole level. (1998) (25)
- Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. (2013) (25)
- Improved molecular weight-based processing of intact proteins for interrogation by quadrupole-enhanced FT MS/MS. (2004) (25)
- Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin. (2004) (24)
- STORI Plots Enable Accurate Tracking of Individual Ion Signals (2019) (24)
- Systems Proteomics View of the Endogenous Human Claudin Protein Family. (2016) (24)
- Cofactor Biosynthesis: A Mechanistic Perspective (1998) (23)
- Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top Down Mass Spectrometry. (2020) (22)
- Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. (2018) (22)
- Mass Spectrometry Screening Reveals Peptides Modulated Differentially in the Medial Prefrontal Cortex of Rats with Disparate Initial Sensitivity to Cocaine (2010) (22)
- Fragmentation of Integral Membrane Proteins in the Gas Phase (2014) (22)
- Global amine and acid functional group modification of proteins. (2008) (21)
- Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform. (2015) (21)
- Oncogene‐induced cellular senescence elicits an anti‐Warburg effect (2013) (21)
- Regioselectivity and Chemoselectivity Analysis of Oxazole and Thiazole Ring Formation by the Peptide-Heterocyclizing Microcin B17 Synthetase Using High-Resolution MS/MS (1998) (21)
- Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115) (2015) (21)
- Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells. (2009) (21)
- Double stranded DNA sequencing by tandem mass spectrometry (1997) (20)
- Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains. (2018) (20)
- Toward Efficient Analysis of >70 kDa Proteins with 100% Sequence Coverage (2001) (20)
- Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides by Using Fourier‐Transform Mass Spectrometry (2006) (20)
- Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high‐resolution mass spectrometry (2005) (19)
- Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities. (2021) (19)
- Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry. (2018) (19)
- Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection (2016) (19)
- β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site. (2018) (19)
- Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry. (2020) (18)
- Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions. (2020) (18)
- Deeper Protein Identification Using Field Asymmetric Ion Mobility Spectrometry in Top-Down Proteomics. (2021) (18)
- Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. (2018) (18)
- A Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry. (2019) (17)
- Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS (2020) (17)
- A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's‐associated pathologies (2019) (17)
- Cell Surface Proteomics of N‐Linked Glycoproteins for Typing of Human Lymphocytes (2017) (16)
- Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity. (2018) (16)
- Putting Humpty Dumpty Back Together Again: What Does Protein Quantification Mean in Bottom-Up Proteomics? (2022) (16)
- Spinning up mass spectrometry for whole protein complexes (2012) (16)
- Mechanism of N 2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H 2 (2018) (15)
- In Vitro Characterization of a Heterologously Expressed Nonribosomal Peptide Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis† (2009) (15)
- Modulation of Protein Fragmentation Through Carbamylation of Primary Amines (2017) (15)
- Strategies for automating top-down protein analysis with Q-FTICR MS (2004) (15)
- Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea* (2016) (15)
- Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry. (2015) (14)
- Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins. (2018) (14)
- Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators. (2015) (14)
- Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage. (2015) (14)
- Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS. (2010) (13)
- Contemporary mass spectrometry for the direct detection of enzyme intermediates. (2005) (13)
- Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding (2019) (12)
- Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. (2017) (12)
- Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. (2015) (12)
- A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. (2011) (12)
- Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin (2017) (11)
- Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry (2019) (11)
- A synthetic biology approach to probing nucleosome symmetry (2017) (11)
- Mechanistic Studies on Thiaminase I OVEREXPRESSION AND IDENTIFICATION OF THE ACTIVE SITE NUCLEOPHILE* (1996) (11)
- A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. (2020) (11)
- Standard procedures for native CZE‐MS of proteins and protein complexes up to 800 kDa (2021) (11)
- Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics* (2019) (11)
- Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics* (2019) (11)
- Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. (2019) (10)
- Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. (2016) (10)
- Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma (2020) (10)
- Using 10,000 fragment ions to inform scoring in native top-down proteomics. (2020) (10)
- Complete large-molecule high-resolution mass spectra from 50-femtomole microvolume injection (1995) (10)
- Protein and peptide analysis by LC-MS : experimental strategies (2011) (10)
- Proteoform‐Selective Imaging of Tissues Using Mass Spectrometry (2021) (9)
- Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics (2015) (9)
- Fourier-transform mass spectrometry for detection of thioester-bound intermediates in unfractionated proteolytic mixtures of 80 and 191 kDa portions of Bacitracin A synthetase (2003) (9)
- The Human Proteoform Project: A Plan to Define the Human Proteome (2020) (9)
- CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis. (2016) (9)
- Loss of the Histone Demethylase UTX Contributes to Multiple Myeloma and Sensitizes Cells to EZH2 Inhibitors (2014) (9)
- Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly. (2005) (9)
- Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. (2005) (8)
- Multidimensional Top-Down Proteomics of Brain Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol. (2019) (8)
- Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes (2021) (8)
- Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry. (2005) (8)
- Back Cover: Identification and Quantification of Proteoforms by Mass Spectrometry (2019) (8)
- Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis-Top-Down Mass Spectrometry. (2021) (8)
- Identification of Phosphorylated Human Peptides by Accurate Mass Measurement Alone. (2011) (7)
- Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes (2019) (7)
- New Interface for Faster Proteoform Analysis: Immunoprecipitation Coupled with SampleStream-Mass Spectrometry. (2021) (7)
- Proteomics Standards Initiative’s ProForma 2.0: Unifying the Encoding of Proteoforms and Peptidoforms (2021) (7)
- Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status" (2016) (7)
- Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire (2021) (7)
- Mapping the Proteoform Landscape of Five Human Tissues (2022) (7)
- Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds (2020) (7)
- An efficient cell‐free protein synthesis platform for producing proteins with pyrrolysine‐based noncanonical amino acids (2022) (6)
- SPT6 functions in transcriptional pause/release via PAF1C recruitment. (2022) (6)
- In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins. (2021) (6)
- Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster. (2020) (6)
- Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. (2017) (6)
- Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry (2022) (6)
- Chromatographic efficiency and selectivity in top-down proteomics of histones. (2017) (6)
- The Search Engine for Multi‐Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes (2016) (6)
- Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics. (2019) (6)
- Elucidating proteoform dynamics underlying the senescence associated secretory phenotype. (2020) (5)
- Discovery of the Biosynthetic Machinery for the Stravidins, Biotin Antimetabolites. (2019) (5)
- MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation (2013) (5)
- Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry. (2015) (5)
- Reassembling protein complexes after controlled disassembly by top-down mass spectrometry in native mode. (2021) (5)
- Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics. (2022) (5)
- New Views of Old Proteins: Clarifying the Enigmatic Proteome (2021) (5)
- Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells (2021) (5)
- Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs. (2012) (5)
- Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics. (2016) (5)
- C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways (2022) (5)
- A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis (2022) (5)
- Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. (2013) (5)
- Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. (2020) (5)
- Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study (2021) (5)
- Streptomyces buecherae sp. nov., an actinomycete isolated from multiple bat species (2020) (4)
- Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics? (2021) (4)
- Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells (2018) (4)
- Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. (2021) (4)
- 365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma. (2016) (4)
- Should LC-MS/MS Be the Reference Measurement Procedure to Determine Protein Concentrations in Human Samples? (2020) (4)
- Development of novel methods for non-canonical myeloma protein analysis with an innovative adaptation of immunofixation electrophoresis, native top-down mass spectrometry, and middle-down de novo sequencing (2020) (4)
- Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics. (2020) (4)
- Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. (2021) (4)
- Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. (2020) (4)
- An Essential Role for Alzheimer’s-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis (2022) (3)
- Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma (2020) (3)
- Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry. (2006) (3)
- Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. (2015) (3)
- Size-Sorting Combined with Improved Nanocapillary-LC-MS for Identification of Intact Proteins up to 80 kDa (2010) (3)
- Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire (2021) (3)
- Status of mass spectrometry-based proteomics and metabolomics in basic and translational research. (2013) (3)
- Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development (2005) (3)
- Top-down proteomics. (2004) (3)
- A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified forms (2018) (3)
- Characterization of a Copper-Chelating Natural Product from the Methanotroph Methylosinus sp. LW3. (2021) (3)
- Direct Measurement of Light and Heavy Antibody Chains Using Differential Ion Mobility Spectrometry and Middle-Down Mass Spectrometry (2019) (3)
- ProSight Annotator: Complete control and customization of protein entries in UniProt XML files (2022) (3)
- A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities (2019) (3)
- Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. (2022) (2)
- Focus in honor of roman zubarev, Recipient of the 2007 biemann medal (2008) (2)
- Correlative metabologenomics of 110 fungi reveals metabolite-gene cluster pairs. (2023) (2)
- FIRST‐IN‐CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN‐HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY (2019) (2)
- Precise Characterization of KRAS4B Proteoforms by Combining Immunoprecipitation with Top-Down Mass Spectrometry. (2021) (2)
- The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyi-L-2,3-diaminopropionate for Fe(II)/ α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis [Journal of the American (2011) (2)
- The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms (2021) (2)
- Multiplexed Single Ion Mass Spectrometry Improves Measurement of Proteoforms and Their Complexes (2019) (2)
- Electron Capture Dissociation Produces Many More Protein Backbone Cleavages Than Collisional and IR Excitation (2000) (2)
- Abstract PL05-02: MMSET: A pathogenic factor and therapeutic target in multiple myeloma. (2011) (2)
- Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response (2019) (2)
- The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth (2018) (2)
- Dissecting Non‐Ribosomal and Polyketide Biosynthetic Machineries Using Electrospray Ionization Fourier‐Transform Mass Spectrometry (2007) (2)
- PDTM-28. TARGETED INHIBITION OF EZH2 AND BET BROMODOMAIN PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS (2017) (2)
- Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma (2018) (2)
- SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis. (2022) (2)
- Accurate Estimation of False Discovery Rates for Protein and Proteoform Identification in Top Down Proteomics (2016) (2)
- Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes. (2019) (2)
- Standard Procedures for Native CZE-MS of Proteins and Protein Complexes up to 800 kDa (2020) (2)
- Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas (2017) (2)
- Targeted detection and quantitation of histone modifications from 1,000 cells (2020) (2)
- In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy (2016) (1)
- Top-down proteomics data analysis on the NRTDP TDPortal v1 (2020) (1)
- 25th ASMS Sanibel Conference on Top Down Mass Spectrometry (2013) (1)
- Protocol for Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS: Sample Preparation, Data Acquisition and Analysis (2021) (1)
- Native Proteomics: A New Approach to Protein Complex Discovery and Characterization (2017) (1)
- Direct Imaging and Identification of Proteoforms up to 70 kDa from Human Tissue (2021) (1)
- Revving an Engine of Human Metabolism: Activity Enhancement of Triosephosphate Isomerase via Hemi-Phosphorylation. (2022) (1)
- Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling (2022) (1)
- Mechanistic studies on thiamin formation and degradation: Thiaminase I and thiamin phosphate synthase (1998) (1)
- Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture (2020) (1)
- Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor. (2022) (1)
- Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response (2022) (1)
- Identification of Plasmodium falciparum proteoforms from liver stage models (2020) (1)
- Deeper Protein Identification by Using FAIMS in Top-down Proteomics (2021) (1)
- Front Cover: Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes (2017) (1)
- Abstract 12: KMD6A/UTX loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition (2017) (1)
- Jimmys beach sand renourishment scheme (2009) (1)
- Preparative Electrophoresis for HDL Particle Size Separation and Intact-Mass Apolipoprotein Proteoform Analysis. (2023) (1)
- To cyclize or not to cyclize: catching enzyme evolution in the act. (2009) (1)
- Offshore Dredging for Beach Nourishment; Shoal Bay, N.S.W. (1995) (1)
- Characterizing the plantazolicins: structure and discriminating activity of a novel class of natural products (2012) (0)
- Top-down proteomic analysis by use of molecular weight-based separation and online nanoLC-FTMS (2011) (0)
- pyoluteorin biosynthesis-dependent halogenase PltA during 2 Dichlorination of a pyrrolyl-S-carrier protein by FADH (2005) (0)
- P107-M A Workflow to Enable Intelligent and Targeted S in High-Throughput Mass Spectrometry Experiments. (2007) (0)
- Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria (2018) (0)
- Inside Cover: Improving Cell-Free Protein Synthesis through Genome Engineering of Escherichia coli Lacking Release Factor 1 (ChemBioChem 5/2015) (2015) (0)
- Allele-Specific Crispr Targeting Reveals Epigenetic and Phenotypic Effects of a MMSET Gain of Function Mutation Found in Relapsed Acute Lymphoblastic Leukemia (2015) (0)
- Streptomyces buecherae sp. nov., an actinomycete isolated from multiple bat species (2020) (0)
- "Mapping Proteoforms and Their Dynamics in Cells Responding to DNA-Damage" (2013) (0)
- Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis – Top-Down Mass Spectrometry (nCZE-TDMS) (2020) (0)
- Special Issue: Post-translational Modifications (2013) (0)
- Spectrometry Coupled with Top Down Mass Two-dimensional Liquid Chromatography Histone H 4 Quantitated by Combinatorial Modification of Human and Chromosome Dynamics : DNA : Replication , Repair , Recombination (2008) (0)
- Online capillary LC-FTMS for the analysis of covalent enzyme intermediates of polyketide and nonribosomal peptide synthetases (2002) (0)
- Top-Down Immunoglobulin Light chain Sequence Determination in Patients with POEMS Syndrome (2017) (0)
- A platform for high-throughput identification and characterization of intact proteins from Methanococcus jannaschii (2002) (0)
- CHAPTER 6. Field Asymmetric Ion Mobility Spectrometry (FAIMS) for Advanced Mass Spectrometry (2021) (0)
- Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases (2021) (0)
- Abstract SY30-04: Can protein discovery with complete molecular specificity increase return on investment for cancer biomarkers (2015) (0)
- Abstract PO-10: Histone 1 deficiency drives lymphoma through disruption of 3D chromatin architecture (2020) (0)
- Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes (2020) (0)
- Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia (2016) (0)
- Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy (2010) (0)
- Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator (2017) (0)
- The Use of Methionine Sulfoxide Reductases to Reverse Oxidized Methionine for Mass Spectrometry Applications (2016) (0)
- STORI Plots Enable Accurate Tracking of Individual Ion Signals. (2019) (0)
- BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes (2015) (0)
- Rat Liver Repopulation by Transplanted Late Gestation Fetal Hepatocytes (2017) (0)
- Abstract 15086: Associations Between Apolipoprotein A-I Proteoforms and Markers of Cardiometabolic Health (2019) (0)
- GELFrEE Protocol v1 (2020) (0)
- Identification of Plasmodium falciparum proteoforms from liver stage models (2020) (0)
- Contents: Proteomics 19'15. (2015) (0)
- Pig Brain GABA-AT inactivated by (E)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic acid (2015) (0)
- The emergence of top-down proteomics in clinical research (2013) (0)
- RhoC IP for MS v1 (2021) (0)
- Top-down proteomics data acquisition v1 (2020) (0)
- COL4A IP for MS v1 (2021) (0)
- Optimization of IP-TDMS for Soluble Proteins - Direct Method v1 (2020) (0)
- Adaptation of Native GELFrEE for HDL Particle Size Subtype Separation and Differential Apolipoprotein Proteoform Quantification (2022) (0)
- MAP17 IP for MS v1 (2021) (0)
- Mapping every protein in the human body (2021) (0)
- A comprehensive pipeline for translational top-down proteomics from a single blood draw (2018) (0)
- Phosphorylation of histone H1 at specific sites during gene transcription (2010) (0)
- Aldolase B IP for MS v1 (2020) (0)
- General IP-TDMS for Soluble Proteins - Indirect Method v1 (2020) (0)
- Proteomanalyse (2021) (0)
- Translational Top Down Proteomics of KRAS‐driven Cancers and Models Thereof (2017) (0)
- p16 Ink4a IP for MS v1 (2021) (0)
- Divergent Antibody Repertoires Found for Omicron versus Wuhan SARS-CoV-2 Strains Using Ig-MS (2022) (0)
- Trop2 IP for MS v1 (0)
- High‐Throughput Natural Products Discovery in Fungi Using FAC‐MS Technology (2017) (0)
- Strategies for top-down proteomics of Methanococcus jannaschii and Saccharomyces cerevisiae using a quadrupole FT-ICR-MS (2002) (0)
- COL4A IP for MS v2 (2021) (0)
- Venom characterization of the Brazilian Pampa snake Bothrops pubescens by top-down and bottom-up proteomics. (2022) (0)
- Overall protocol for top-down LC-MS/MS of human kidney tissue v1 (2020) (0)
- Coupling Fluorescence‐Activated Cell Sorting and Targeted LC‐MS/MS for Epi‐Proteomic Analysis of Normal Leukocytes (2018) (0)
- GATA3 IP for MS v1 (2020) (0)
- p21 IP for MS v1 (2021) (0)
- Alpha-crystallin B IP for MS v1 (2020) (0)
- Vim IP for MS v1 (2021) (0)
- Standard Operating Procedure for Immunoprecipitation-Top Down Mass Spectrometry of Integral Membrane Proteins v1 (2020) (0)
- PCNA IP for MS v1 (2020) (0)
- Optimization of IP-TDMS for Soluble Proteins - Direct Method v2 (2020) (0)
- Fibronectin IP for MS v1 (2021) (0)
- A blood cell atlas to guide us toward transplant success (2023) (0)
- New Polymeric Capillary Columns for the Separation of Whole Proteins (2014) (0)
- Analysing protein post-translational modform regions by linear programming (2018) (0)
- MEK1 IP for TDMS v1 (2020) (0)
- Proteomic Profiling of Histone Posttranslational Modifications in Late Gestation Fetal Hepatocytes Capable of Liver Repopulation (2015) (0)
- - Fumaramoyl-L-2 , 3-diaminopropionate for Fe ( II ) / r-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis (2010) (0)
- Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid (2023) (0)
- Thioesterase function in the synthetase of the siderophore enteroe (1999) (0)
- Na+/K+ ATPaseIP for MS v1 (2021) (0)
- Processing complex mixtures of yeast proteins for direct fragmentation in a quadrupole-FTMS hybrid (2002) (0)
- NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle (2020) (0)
- BAMS: A Robust Analytical Platform for Quantifying Histone Modi fi cations and Various Proteoforms by IP MALDI MS (2022) (0)
- Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase". (2023) (0)
- Reviving natural product and drug discovery pipelines with fungal artificial chromosome (FAC) technology (2016) (0)
- Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression (2015) (0)
- Troponin I IP for MS v1 (2021) (0)
- Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain (2017) (0)
- 20 by Suv 4-20 Preferential Dimethylation of Histone H 4 Epigenetics : Transcription , Chromatin (2008) (0)
- Analysis of Intact Protein Isoforms by Mass (2011) (0)
- Abstract A26: Precise characterization and comparison of KRAS proteoforms by top-down mass spectrometry (2020) (0)
- (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase (2019) (0)
- Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase (2019) (0)
- A five-level classification system for proteoform identifications (2019) (0)
- General IP-TDMS for Soluble Proteins - Direct Method v1 (2020) (0)
- P107-M A Workflow to Enable Intelligent and Targeted Second-Chance in High-Throughput Mass Spectrometry Experiments (2007) (0)
- Methodologies for Metabolomics: Approaches for Natural Product Detection and Structural Elucidation Using Mass Spectrometry with High Mass Accuracy (2013) (0)
- Fungal artificial chromosomes for mining of the fungal secondary metabolome (2015) (0)
- phosphopantetheinyl transferase Genetically encoded short peptide tag for versatile protein labeling by Sfp (2005) (0)
- Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence (2017) (0)
- Global Chromatin Occupancy and Epigenetic Signature Analysis Reveal New Insights into the Function of GATA1 N-Terminus in Erythropoiesis (2018) (0)
- Abstract B32: Loss of the histone demethylase UTX alters the gene expression prolife and contributes to the malignant phenotype of multiple myeloma cells. (2015) (0)
- National resource for translational and developmental proteomics Galaxy portal (2016) (0)
- Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. (2017) (0)
- Electron capture dissociation for robust production of sequence tags from eukaryotic proteins (2002) (0)
- Automated Control of Injection Times for Unattended Acquisition of Multiplexed Individual Ion Mass Spectra. (2022) (0)
- Evaluation of electron capture dissociation for D atom localization at the peptide and protein levels after solution phase exchange (2002) (0)
- A basal gene expression signature to predict for synergy of combined EZH2 and HDAC inhibition in EZH2 dysregulated lymphomas. (2018) (0)
- GENT-51. EPIGENETIC PROFILING REVEALS A UNIQUE HISTONE CODE IN CHORDOMA (2016) (0)
- Abstract LB-101: Combined p53 dynamics and post-translational modifications determine subsequent protein expression and cell fate (2019) (0)
- Top Down Mass Spectrometry of Larger (200 kDa) Proteins Cracking the Histone Code: A Mass Spectrometry-based Approach for the Determination of Histone Modifications (2005) (0)
- Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids (2018) (0)
- MMSET Contributes to Multiple Myeloma Oncogenesis Through Induction of Global Epigenetic Changes and Alteration of the DNA Damage Response (2011) (0)
- Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators (2020) (0)
- 365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma. (2016) (0)
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