Neil Osheroff

Neil Osheroff's AcademicInfluence.com Rankings

Neil Osheroff

Biology

#8240

World Rank

#11284

Historical Rank

Biochemistry

#1179

World Rank

#1298

Historical Rank

biology Degrees

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Biology

Neil Osheroff's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Neil Osheroff's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mechanism of Quinolone Action and Resistance (2014) (813)
Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme. (1998) (511)
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism (*) (1995) (506)
Etoposide, topoisomerase II and cancer. (2005) (448)
In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction. (1985) (408)
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing (2008) (388)
Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. (2000) (346)
DNA topoisomerase II, genotoxicity, and cancer. (2007) (343)
DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. (1983) (261)
DNA topoisomerase II in therapy-related acute promyelocytic leukemia. (2005) (261)
Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage* (1998) (245)
Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide. (1989) (231)
Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. (1990) (228)
Biochemical basis for the interactions of type I and type II topoisomerases with DNA. (1989) (227)
Catalytic function of DNA topoisomerase II (1991) (218)
When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs. (1993) (211)
Eukaryotic topoisomerase II. Characterization of enzyme turnover. (1986) (194)
Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro. (1985) (182)
Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde. (2001) (169)
Topoisomerase II and leukemia (2014) (166)
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes. (2003) (160)
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases (2010) (147)
Topoisomerase II and the etiology of chromosomal translocations. (2006) (146)
Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. (1991) (140)
Topoisomerase II·Etoposide Interactions Direct the Formation of Drug-induced Enzyme-DNA Cleavage Complexes* (1996) (138)
Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ (2007) (138)
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. (2005) (137)
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance (2013) (133)
Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II. (1991) (132)
A Two-drug Model for Etoposide Action against Human Topoisomerase IIα* (2003) (132)
Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA. (1995) (129)
Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II (2010) (121)
Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form. (1987) (119)
Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints. (1997) (118)
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity (2012) (115)
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. (2008) (111)
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast. (1992) (108)
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. (1989) (106)
1,4-Benzoquinone is a topoisomerase II poison. (2004) (103)
Phosphorylation of DNA topoisomerase II in vivo and in total homogenates of Drosophila Kc cells. The role of casein kinase II. (1988) (100)
Apurinic Sites Are Position-specific Topoisomerase II Poisons* (1997) (99)
First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. (2010) (99)
Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit. (1990) (98)
DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization. (1983) (98)
DNA topoisomerase IIα interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution (2000) (96)
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide. (1990) (96)
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells. (1989) (95)
Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation (1999) (95)
Definition of cytochrome c binding domains by chemical modification: kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain. (1979) (95)
Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase. (1978) (95)
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. (2008) (94)
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions. (2000) (93)
Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II (1995) (92)
Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide. (1992) (92)
DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition. (1999) (92)
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group (1992) (91)
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation (2001) (89)
A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines* (2000) (87)
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. (2008) (87)
The response of eukaryotic topoisomerases to DNA damage. (1998) (87)
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II. (1993) (86)
Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. (2001) (83)
DNA topology and topoisomerases (2008) (83)
Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage. (1994) (79)
Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. (2019) (79)
Electrostatic interactions in cytochrome c. The role of interactions between residues 13 and 90 and residues 79 and 47 in stabilizing the heme crevice structure. (1980) (79)
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. (2002) (76)
From music to macromolecules: Using rich media/podcast lecture recordings to enhance the preclinical educational experience (2008) (76)
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. (2012) (76)
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. (2004) (75)
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. (2012) (74)
Topoisomerase IV Catalysis and the Mechanism of Quinolone Action* (1998) (74)
Mechanism of action of topoisomerase II-targeted antineoplastic drugs. (1994) (73)
Role of the divalent cation in topoisomerase II mediated reactions. (1987) (73)
A Yeast Type II Topoisomerase Selected for Resistance to Quinolones (1995) (72)
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. (2010) (71)
DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action. (2001) (68)
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase (2016) (68)
Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα. (2015) (67)
Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. (2007) (66)
Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage* (1997) (64)
Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c. (1980) (63)
Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential (1993) (63)
N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. (2004) (62)
Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing (2003) (62)
Mapping of the interaction domain for purified cytochrome c 1 on cytochrome c (1980) (62)
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. (2013) (61)
Oxidative metabolites of curcumin poison human type II topoisomerases. (2013) (61)
The reaction of primate cytochromes c with cytochrome c oxidase. Analysis of the polarographic assay. (1983) (61)
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. (2006) (61)
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. (2007) (59)
A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavage. (1992) (59)
DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement. (1999) (59)
Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation. (1993) (58)
Metnase promotes restart and repair of stalled and collapsed replication forks (2010) (58)
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. (2008) (58)
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification (2011) (58)
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site (2002) (57)
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. (2011) (56)
Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance. (1999) (56)
Base Excision Repair Intermediates as Topoisomerase II Poisons* (2001) (54)
The use of divalent metal ions by type II topoisomerases. (2010) (53)
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. (2008) (53)
Activities of gyrase and topoisomerase IV on positively supercoiled DNA (2017) (53)
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103. (2000) (52)
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA (2012) (52)
The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II. (1998) (52)
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. (2007) (52)
Biological characterization of MLN944: a potent DNA binding agent. (2004) (51)
Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. (2005) (51)
Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction. (1989) (51)
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. (2008) (50)
Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage (2008) (49)
Topoisomerase II from Chlorella Virus PBCV-1 (2000) (48)
A Mutation in Yeast TOP2 Homologous to a Quinolone-resistant Mutation in Bacteria (1995) (48)
Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination. (1992) (48)
Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues. (1980) (48)
Phytochemicals as anticancer and chemopreventive topoisomerase II poisons (2014) (47)
Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis. (1992) (47)
Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. (2005) (46)
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci. (2017) (46)
Etoposide quinone is a redox-dependent topoisomerase II poison. (2011) (45)
Quinolones Inhibit DNA Religation Mediated by Staphylococcus aureus Topoisomerase IV (1999) (45)
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. (2003) (45)
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme. (1993) (44)
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. (1997) (43)
Activation of the DNA-Dependent Protein Kinase by Drug-Induced and Radiation-Induced DNA Strand Breaks (2003) (43)
Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics. (1981) (43)
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. (2005) (42)
Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ (2014) (41)
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. (2003) (41)
DNA Topoisomerases: Type II (2004) (41)
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. (2008) (40)
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. (2006) (39)
Topoisomerase II from Chlorella Virus PBCV-1 Has an Exceptionally High DNA Cleavage Activity* (2001) (39)
Use of singly modified cytochrome c derivatives to determine the site for electron transfer in reactions with inorganic complexes (1981) (38)
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II (2005) (38)
Topoisomerase II-mediated cleavage of plasmid DNA. (2001) (38)
Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα (2014) (37)
Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100β (1994) (37)
Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV (2014) (36)
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. (2008) (36)
DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison. (1999) (35)
Communication between the ATPase and Cleavage/Religation Domains of Human Topoisomerase IIα* (2000) (34)
Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single-stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate. (1990) (34)
Molecular Pathogenesis of Secondary Acute Promyelocytic Leukemia (2011) (33)
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. (2005) (33)
Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers. (1991) (32)
DNA topoisomerase protocols (1999) (32)
Purification and characterization of a periplasmic oligopeptide binding protein from Escherichia coli. (1985) (32)
Topoisomerase II-mediated DNA Cleavage and Religation in the Absence of Base Pairing (1998) (31)
Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides (2006) (30)
Cytosine Arabinoside Lesions Are Position-specific Topoisomerase II Poisons and Stimulate DNA Cleavage Mediated by the Human Type II Enzymes* (1999) (30)
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. (2007) (30)
Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives. (2016) (29)
Covalent attachment of ethidium to DNA results in enhanced topoisomerase II-mediated DNA cleavage. (1997) (29)
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I (2010) (28)
Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα*♦ (2013) (27)
Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes. (1983) (27)
Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism (2014) (26)
Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases (2015) (26)
Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement. (2000) (26)
Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine. (1997) (26)
In Vitro Evolution of Preferred Topoisomerase II DNA Cleavage Sites* (1999) (26)
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal (2007) (25)
Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. (2006) (25)
The presteady state reaction of chemically modified cytochromes c with cytochrome oxidase. (1983) (25)
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV (2011) (24)
Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions. (2015) (23)
A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential (1993) (23)
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. (2009) (23)
Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation (2013) (23)
Site-specific DNA cleavage by Chlorella virus topoisomerase II. (2002) (22)
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. (2013) (22)
Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons. (2018) (20)
Purification of DNA topoisomerase II from Drosophila melanogaster. (1999) (20)
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. (2008) (20)
DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer (2008) (19)
Lactoperoxidase-catalyzed iodination of horse cytochrome c:monoiodotyrosyl 74 cytochrome c. (1977) (19)
Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences (2018) (18)
DNA cleavage and religation by human topoisomerase II alpha at high temperature. (2001) (18)
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. (2009) (18)
Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex. (2011) (17)
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors. (2021) (17)
Human Topoisomerase IIα Rapidly Relaxes Positively Supercoiled DNA (2005) (17)
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. (2009) (16)
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. (2017) (16)
Integrating Foundational Sciences in a Clinical Context in the Post-clerkship Curriculum (2018) (16)
Increased Drug Affinity as the Mechanistic Basis for Drug Hypersensitivity of a Mutant Type II Topoisomerase (*) (1995) (16)
Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination (2019) (16)
Preferred sites on cytochrome c for electron transfer with two positively charged blue copper proteins, Anabaena variabilis plastocyanin and stellacyanin. (1986) (15)
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. (2002) (15)
Positioning the 3′-DNA Terminus for Topoisomerase II-mediated Religation* (2001) (15)
Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme (1993) (15)
A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP* (1998) (14)
EFFECTS OF ANIONS ON THE REACTION BETWEEN CYTOCHROME c AND CYTOCHROME c OXIDASE 1 (1978) (14)
Topoisomerase II-catalyzed relaxation and catenation of plasmid DNA. (2001) (14)
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β (2020) (13)
DNA Ligation Catalyzed by Human Topoisomerase IIα (2004) (12)
Topoisomerase IIα Binding Domains of Adenomatous Polyposis Coli Influence Cell Cycle Progression and Aneuploidy (2010) (12)
Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. (2005) (11)
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase (2017) (11)
Bimodal actions of a naphthyridone/aminopiperidine-based antibacterial that targets gyrase and topoisomerase IV. (2019) (11)
Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance (2017) (11)
Cleavage of plasmid DNA by eukaryotic topoisomerase II. (2009) (11)
Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance (2018) (11)
Topoisomerase II-catalyzed ATP hydrolysis as monitored by thin-layer chromatography. (2001) (10)
Site-specific anti-cytochrome c antibodies. Inhibition of the reactions between cytochrome c and its respiratory chain electron exchange partners. (1979) (10)
From Theory to Practice: Utilizing Competency-Based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-clerkship Medical School Curriculum (2016) (10)
DNA topology and enzymes (1999) (10)
Bacillus anthracis GrlAV96A Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge (2014) (10)
Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback (2017) (10)
DNA ligation catalyzed by human topoisomerase II alpha. (2004) (9)
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. (2022) (9)
Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA. (2019) (9)
Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ. (2018) (9)
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events (2017) (8)
6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases. (2019) (8)
Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II (2019) (8)
Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta. (1994) (7)
DNA Topoisomerase Protocols: Volume I: DNA Topology and Enzymes (1999) (7)
DNA topoisomerases. (1998) (7)
Introduction to DNA topoisomerases. (1999) (7)
Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes (2004) (7)
Topoisomerase-Induced DNA Damage (2012) (6)
1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases. (2021) (6)
Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids (2021) (6)
Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα. (2017) (6)
Evolving Role of the Basic Science Course Director in an Integrated Curriculum (2014) (5)
Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα. (2016) (5)
Quinolones and Eukaryotic Topoisomerases (2003) (5)
Topoisomerase IB-DNA interactions: X marks the spot. (2010) (5)
DNA Methylation Impacts the Cleavage Activity of Chlorella Virus Topoisomerase II (2005) (5)
DNA Topology and its Biological Effects. Based on a Cold Spring Harbor Meeting Held in 1986.Nicholas R. Cozzarelli , James C. Wang (1991) (5)
Biochemical mechanism of apoptotic execution. (2000) (4)
Topoisomerase II Inhibitors: Chemical Biology (2012) (4)
Mechanism of action of topoisomerase II-targeted anticancer drugs (2003) (3)
Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers. (2014) (3)
Two-Dimensional Gel Electrophoresis to Resolve DNA Topoisomers. (2020) (3)
Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. (2017) (3)
Regulation of DNA Topology by Topoisomerases: Mathematics at the Molecular Level (2016) (3)
Teaching Biochemistry and Genetics to Students of Medicine, Pharmacy, and Dentistry (2017) (3)
DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II. (2005) (3)
Human Topoisomerase IIα Possesses an Intrinsic Nucleic Acid Specificity for DNA Ligation (2002) (2)
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms (2021) (2)
Research Report Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100/3 (1994) (2)
Gyrase and Topoisomerase IV as Targets for Antibacterial Drugs (2014) (2)
The Relation between the Dipole Moment of Cytochrome c and the Activity with Cytochrome c Reductase and Cytochrome c Oxidase (1982) (2)
Role of caspases in apoptotic execution (1999) (2)
Teaching Biochemistry to Students of Medicine, Pharmacy & Dentistry (2015) (1)
The phase I clinical compound SNS-595 acts during S-phase and causes a sustained G2 arrest (2005) (1)
DNA Recognition/Processing | DNA Topoisomerases: Type II (2021) (1)
Teaching Biochemistry and Genetics to Students of Medicine, Pharmacy, and Dentistry (2017) (1)
Teaching Biochemistry to Students of Medicine, Pharmacy and Dentistry (2015) (1)
From Theory to Practice: Utilizing Competency-Based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-clerkship Medical School Curriculum (2016) (1)
Unraveling the structure of the variola topoisomerase IB-DNA complex: a possible new twist on smallpox therapy. (2006) (1)
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. (2022) (1)
Analysis of topoisomerase II-mediated DNA cleavage in the 5'-region of the Drosophila hsp70 gene. Identification of a novel half-site DNA substrate for topoisomerase II cleavage. (1993) (1)
DNA Topoisomerase II Poisons and the Etiology of Acute Leukemia in Infants. (2005) (1)
GeneticsUntangling the Double Helix: DNA Entanglement and the Action of the DNA Topoisomerases.ByJames C.Wang. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. $79.00 (hardcover); $45.00 (paper). xi 233 p.; ill.; index. 9780879698638 (hc); 9780879698799 (pb). 2009. (2010) (0)
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase (2023) (0)
Zooming into the COVID Era Together (2022) (0)
Molecular Characterization of the t(15;17)(q22;21) in Epirubicin-Related Acute Promyelocytic Leukaemia (2008) (0)
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases. (2023) (0)
Topoisomerase II-DNA cleavage complex, metal-bound (2010) (0)
Getting stressed over topoisomerase I poisons. (2021) (0)
SURVEY AND SUMMARY The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing (2009) (0)
Molecular Pathogenesis of Secondary Acute (2011) (0)
Genetics (2010) (0)
Meet Our Editorial Board Member (2020) (0)
Single-Molecule Observation of Dynamic Bending and Cleavage of a Gate DNA by Human Topoisomerase IIα (2011) (0)
NUP98 Translocation Breakpoints in Treatment-Related MDS Are Drug-Stimulated DNA Topoisomerase II Cleavage Sites. (2004) (0)
Olive Leaf Metabolites as Covalent Human Topoisomerase II Poisons (2016) (0)
Molecular mechanisms underlying formation of balanced chromosomal rearrangements in therapy-related acute myeloid leukaemia (2009) (0)
Phytochemicals as anticancer and chemopreventive topoisomerase II poisons (2013) (0)
Abstract #1691: Nicks as poisons of topoisomerase II: coordinating the two protomer subunits of topoisomerase II\#945; (2009) (0)
ATP-Dependent Topology Discrimination by Type IIA Topoisomerases: Implications for below Equilibrium Topology Simplification (2018) (0)
Oxidative Metabolism of Curcumin: Products, Mechanisms, and Biological Activity (2013) (0)
Mitoxantrone induces DNA topoisomerase II cleavage at translocation breakpoint hotspot in PML gene in acute promyelocytic leukemia (2003) (0)
The COVID-19 Pandemic: a Year Lost, or a Year Found? (2021) (0)
Structure and Mechanism of Eukaryotic Type IIA Topoisomerases (2012) (0)
Teaching Biochemistry to Students of Medicine, Pharmacy and Dentistry (2015) (0)
Novel 9-amino acridone derivatives as potential topoisomerase II inhibitors (2020) (0)
IV: A Quinolone Resistance Mutation that Does Not Affect the (2014) (0)
Purification and Characterization of a Periplasmic Oligopeptide Binding Protein from Escherichia coZi* (2001) (0)
DNA supercoil geometry differentially affects the stability of DNA cleavage complexes formed by different type II topoisomerases (2021) (0)
Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases. (2022) (0)
Evolving Role of the Basic Science Course Director in an Integrated Curriculum (2014) (0)
Abstract 2529: Structure-activity relationship studies of the type II topoisomerase poison amsacrine (2011) (0)
Diagnosis and outcome prediction for childhood acute leukaemia by gene expression profiling (2004) (0)
Integrating Foundational Sciences in a Clinical Context in the Post-clerkship Curriculum (2018) (0)
Determining the Role DNA of Bending in Topology Simplification by Type II Topoisomerases (2010) (0)
Single-Molecule Study of Human Topoisomerase II (2010) (0)
f Secondary Acute Promyelocytic Leukemia (2011) (0)
Topoisomerase II-DNA cleavage complex, apo (2010) (0)
Topoisomerase II-DNA-AMPPNP complex (2012) (0)
Effects of DNA Supercoil Handedness on Catenation by Type II Topoisomerases (2021) (0)
Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback (2017) (0)
38 Molecular pathogenesis and biology of secondary leukaemias (2009) (0)
DNA untangled Topoisomerase enzymes remove our genetic knots (2020) (0)
Etoposide and 4 Cleavage / Religation and Sensitivity to the Antineoplastic Drugs Protein Kinase C : Effects on Enzyme-mediated DNA Phosphorylation of Topoisomerase II by Casein Kinase II and Updated Version (2006) (0)

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What Schools Are Affiliated With Neil Osheroff?

Neil Osheroff is affiliated with the following schools:

University of California, Berkeley
University of Oxford
Vanderbilt University
Northwestern University