Nicholas John Dyson
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Biology
Nicholas John Dyson's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
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(Suggest an Edit or Addition)Nicholas John Dyson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. (1989) (2983)
- The regulation of E2F by pRB-family proteins. (1998) (2441)
- Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. (1989) (1201)
- Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 (1996) (797)
- The E2F transcriptional network: old acquaintances with new faces (2005) (753)
- A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F (1992) (618)
- Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. (1993) (545)
- Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. (2002) (542)
- The retinoblastoma protein binds to a family of E2F transcription factors (1993) (493)
- pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. (1997) (486)
- Shared role of the pRB-related p130 and p107 proteins in limb development. (1996) (470)
- Conserved functions of the pRB and E2F families (2008) (469)
- A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses (2011) (462)
- A revised picture of the E2F transcriptional network and RB function. (2002) (457)
- Molecular mechanisms of E2F-dependent activation and pRB-mediated repression (2004) (417)
- Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins (1992) (409)
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism (2015) (395)
- YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway (2009) (390)
- Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F (1992) (367)
- Targeted disruption of p107: functional overlap between p107 and Rb. (1996) (367)
- Retinoblastoma protein partners. (2001) (366)
- Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice (1998) (334)
- The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. (1990) (324)
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. (2010) (322)
- The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus (1989) (318)
- Nuclear organization of DNA replication in primary mammalian cells. (2000) (315)
- RB1: a prototype tumor suppressor and an enigma (2016) (311)
- Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein (1990) (305)
- Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product (1991) (304)
- Combined Functional Genomic Maps of the C. elegans DNA Damage Response (2002) (296)
- E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8 (2008) (293)
- Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes (2004) (282)
- p107 and p130: versatile proteins with interesting pockets. (2001) (271)
- Quantitatively determined survivin expression levels are of prognostic value in human gliomas. (2002) (268)
- Inactivation of Dnmt3b in Mouse Embryonic Fibroblasts Results in DNA Hypomethylation, Chromosomal Instability, and Spontaneous Immortalization* (2005) (262)
- The transcription factor E2F is required for S phase during Drosophila embryogenesis. (1995) (257)
- RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. (1996) (256)
- pRB plays an essential role in cell cycle arrest induced by DNA damage. (1998) (255)
- Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. (2003) (255)
- Loss of pRB causes centromere dysfunction and chromosomal instability. (2010) (238)
- The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival (2017) (230)
- CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. (2010) (220)
- LKB1 loss links serine metabolism to DNA methylation and tumorigenesis (2016) (219)
- Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. (1998) (214)
- Transcriptional control of the autophagy-lysosome system in pancreatic cancer (2015) (209)
- A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. (2011) (189)
- KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors (2013) (184)
- Functional antagonism between E2F family members. (2001) (179)
- Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit (2007) (172)
- Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (1993) (168)
- Adenovirus E1A targets key regulators of cell proliferation. (1992) (159)
- DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. (1994) (158)
- Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1 (1996) (152)
- Pumilio facilitates miRNA regulation of the E2F3 oncogene. (2012) (152)
- RB: mitotic implications of a tumour suppressor (2012) (142)
- Requirements for cell cycle arrest by p16INK4a. (2000) (142)
- pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. (2003) (141)
- Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. (2010) (132)
- The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis (1999) (130)
- Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts. (2018) (130)
- The Retinoblastoma Protein Regulates Pericentric Heterochromatin (2006) (130)
- RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. (2008) (128)
- E2F-induced S phase requires cyclin E. (1996) (128)
- Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. (1996) (123)
- A kinase shRNA screen links LATS2 and the pRB tumor suppressor. (2011) (122)
- Mutation of Drosophila Lsd1 Disrupts H3-K4 Methylation, Resulting in Tissue-Specific Defects during Development (2007) (121)
- Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins (2000) (120)
- Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo (2006) (120)
- Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 (1993) (119)
- H4K20 methylation regulates quiescence and chromatin compaction (2013) (118)
- Adenovirus E1A makes two distinct contacts with the retinoblastoma protein (1992) (116)
- Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas. (2001) (113)
- PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer. (2019) (113)
- Modeling tumor invasion and metastasis in Drosophila (2011) (112)
- Combination Olaparib and Temozolomide in Relapsed Small Cell Lung Cancer. (2019) (111)
- Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage (2001) (110)
- Non-canonical functions of the RB protein in cancer (2018) (105)
- Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2 (2002) (103)
- CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers. (2014) (99)
- pRB, a tumor suppressor with a stabilizing presence. (2011) (88)
- E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. (2016) (88)
- Loss of RBF1 changes glutamine catabolism. (2013) (87)
- A genetic screen for modifiers of E2F in Drosophila melanogaster. (1999) (85)
- Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. (2006) (81)
- Dp1 is required for extra-embryonic development (2003) (79)
- Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. (2014) (77)
- A Code of Mono-phosphorylation Modulates the Function of RB. (2019) (76)
- Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization (1991) (76)
- Expression of cyclins E1 and E2 during mouse development and in neoplasia (2001) (75)
- Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. (2009) (75)
- Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation (2015) (74)
- Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. (2005) (72)
- pRB, p107 and the regulation of the E2F transcription factor (1994) (70)
- Identification of DHODH as a therapeutic target in small cell lung cancer (2019) (70)
- Requirements for dE2F function in proliferating cells and in post‐mitotic differentiating cells. (1996) (69)
- p55, the Drosophila Ortholog of RbAp46/RbAp48, Is Required for the Repression of dE2F2/RBF-Regulated Genes (2004) (67)
- Examination of the pRb-Dependent and pRb-Independent Functions of E7 In Vivo (2005) (67)
- Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins (2002) (67)
- The multiple connections between pRB and cell metabolism. (2013) (67)
- E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage (2008) (63)
- Functional antagonism between histone H3K4 demethylases in vivo. (2011) (61)
- The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner. (2001) (61)
- A Gradient of Epidermal Growth Factor Receptor Signaling Determines the Sensitivity of rbf1 Mutant Cells to E2F-Dependent Apoptosis (2006) (61)
- Disruption of Retinoblastoma Protein Family Function by Human Papillomavirus Type 16 E7 Oncoprotein Inhibits Lens Development in Part through E2F-1 (1999) (60)
- A role for Ebi in neuronal cell cycle control (2000) (58)
- E2F7 and E2F8 keep the E2F family in balance. (2008) (57)
- RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes (2012) (56)
- pRb, a local chromatin organizer with global possibilities (2010) (50)
- Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation. (2016) (42)
- A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity (2012) (42)
- dDP Is Needed for Normal Cell Proliferation (2005) (41)
- Expression of the Retinoblastoma Protein in Low-Grade B-Cell Lymphoma: Relationship to Cyclin D1 (1996) (39)
- Retinoblastoma Family 2 is Required In Vivo for the Tissue-Specific Repression of dE2F2 target Genes (2005) (38)
- Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation (2014) (38)
- Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. (1996) (38)
- Nuclear Reorganization of Mammalian DNA Synthesis Prior to Cell Cycle Exit (2004) (33)
- G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. (2003) (32)
- SETD1A protects from senescence through regulation of the mitotic gene expression program (2019) (32)
- Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer (2020) (31)
- Cellular proteins that are targetted by DNA tumor viruses for transformation. (1989) (28)
- Clinical Outcomes With Abemaciclib After Prior CDK4/6 Inhibitor Progression in Breast Cancer: A Multicenter Experience. (2021) (26)
- The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival (2008) (25)
- Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells (2014) (25)
- No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice (1999) (24)
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes (2014) (24)
- Processing of mitochondrial RNA in Aspergillus nidulans. (1989) (23)
- E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. (2017) (16)
- In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila (2012) (16)
- Growth suppression by members of the retinoblastoma protein family. (1994) (15)
- Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells (2011) (13)
- The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop (2015) (12)
- The c-myc oncoprotein forms a specific complex with the product of the retinoblastoma gene. (1991) (12)
- Cellular proteins that are targets for transformation by DNA tumour viruses. (1990) (12)
- Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription (2010) (10)
- Metabolic analysis of the loss of Rb1 in vivo (2014) (10)
- Phosphorylation puts the pRb tumor suppressor into shape. (2012) (9)
- The mitochondrial ribosomal RNA molecules of Aspergillus nidulans. (1989) (8)
- APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer (2021) (8)
- In-Vitro Assays to Detect the Interaction of DNA Tumor Virus Transforming Proteins with the Retinoblastoma Protein (1989) (8)
- Active RB causes visible changes in nuclear organization (2022) (8)
- Safety and efficacy of combination olaparib (O) and temozolomide (T) in small cell lung cancer (SCLC). (2018) (7)
- Abstract CT048: Phase 1/2 study of olaparib tablets and temozolomide in patients with small cell lung cancer (SCLC) following failure of prior chemotherapy (2017) (6)
- The emerging roles for histone demethylases in the modulation of signaling pathways (2013) (6)
- THE CELL CYCLE (2010) (5)
- Targeted disruption of pi07: functional overlap between pl07 and Rb (1996) (5)
- Retinoblastoma Protein (pRB) (2004) (5)
- Developmental biology: A twist in a mouse tale (2003) (5)
- Identification of E2F target genes that are rate limiting for dE2F1‐dependent cell proliferation (2012) (5)
- Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. (2022) (4)
- Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer (2022) (4)
- Post-transcriptional regulation by NANOS is up-regulated and functionally significant in pRb deficient cells (2014) (4)
- Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation (2014) (3)
- Diverse Regulatory Functions of the E2F Family of Transcription Factors (2006) (3)
- pRB Takes an EZ Path to a Repetitive Task. (2016) (2)
- Oncogenes and cell proliferation. (1999) (2)
- Identifying players in the functional network around pRB (2011) (2)
- RB-loss puts focus on Myc (2015) (2)
- No Effect of Loss of E 2 F 1 on Liver Regeneration or Hepatocarcinogenesis in C 57 BL / 6 J or C 3 H / HeJ Mice (1999) (1)
- Tumor Suppressors | Retinoblastoma Protein (pRB) (2021) (1)
- Cellular Targets for Transformation by DNA Tumor Viruses (1990) (1)
- A vanishing act, explained. (2008) (1)
- Abstract 1903: PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ká inhibitors in breast cancer (2020) (1)
- Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses (2021) (1)
- Cellular Proteins Implicated in Transformation by Adenovirus and Other DNA Tumor Viruses (1989) (1)
- E2F/Dp inactivation in fat body cells triggers systemic metabolic changes (2021) (1)
- Chapter 2 Interplay Between Cyclin-Dependent Kinases and E 2 F-Dependent Transcription (2010) (1)
- Abstract CT198: Expansion of Phase I/II study of olaparib and temozolomide in patients with relapsed small cell lung cancer (SCLC) and co-clinical trial in patient-derived xenografts (PDXs) for biomarker discovery (2019) (0)
- and cell cycle processes and are critical for stem cell maintenance and pluripotency in worms , flies , mice , and humans (2012) (0)
- Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis (2019) (0)
- Abstract B01: pRb activates mitochondrial metabolism and promotes differentiation through the histone demethylase Kdm5a (2016) (0)
- Method and equipment for biological test (1988) (0)
- It's All in the Timing: Too Much E2F Is a Bad Thing (2012) (0)
- Neuropathological potential of FUS and TDP-43 in flies (2011) (0)
- Non-canonical functions of the RB protein in cancer (2018) (0)
- Abstract 381: Combined inhibition of Bcl-2 and MCL-1 in small cell lung cancer (SCLC) is most effective in tumors with low Bcl-xL expression (2019) (0)
- Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells (2012) (0)
- blocks cell cycle progression in G1. Expression of dominant-negative mutant DP-1 (2013) (0)
- Insulin-like Growth Factor Receptor I Mediates Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Primary Human Glioblastoma Cells through Continued Activation of Phosphoinositide 3-Kinase Signaling 1 (2001) (0)
- Abstract 4736: Dose optimization of olaparib plus temozolomide in small cell lung cancer (SCLC) patient-derived xenograft (PDX) models for clinical translation (2019) (0)
- Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer (2015) (0)
- Metabolic analysis of the loss of Rb1 in vivo (2014) (0)
- Oncogenes and cell proliferation. (1999) (0)
- Seeing is believing: the impact of RB on nuclear organization. (2023) (0)
- Similarity of nucleotide sequences at splicing sites (1988) (0)
- Author Correction: Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses (2021) (0)
- Analysis ofp107-Associated Proteins: p107Associates witha FormofE2FThatDiffers frompRB-Associated E2F-1 (1993) (0)
- Abstract A193: Quantitative global profiling reveals how RB-loss changes the metabolome, transcriptome, and proteome of cells and provides new opportunities to target RB-deficient cancer cells (2018) (0)
- Abstract B42: Metabolic changes, associated with loss of the tumor suppressor LKB1, promote tumorigenesis (2015) (0)
- Abstract 2972: Co-clinical trial of olaparib and temozolomide in SCLC PDX models uncovers new biomarkers of sensitivity (2018) (0)
- Chromatin-bound protein colocalization analysis using bedGraph2Cluster and PanChIP (2023) (0)
- Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses (2021) (0)
- Abstract LB-228: YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway (2009) (0)
- The complex roles of histone demethylases in vivo (2011) (0)
- Abstract IA15: The consequences of pRb inactivation: insights from a proteomic analysis of Rb loss (2016) (0)
- Abstract 1420: The non-canonical role of Rb in enhancers and insulators (2023) (0)
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