Nicholas R. Cozzarelli

Nicholas R. Cozzarelli's AcademicInfluence.com Rankings

Biology

#2807

World Rank

#4394

Historical Rank

#1213

USA Rank

Biochemistry

#403

World Rank

#481

Historical Rank

#153

USA Rank

biology Degrees

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Biology

Nicholas R. Cozzarelli's Degrees

PhD Biochemistry Stanford University
Bachelors Chemistry Columbia University

Why Is Nicholas R. Cozzarelli Influential?

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According to Wikipedia, Nicholas Robert Cozzarelli was an American biochemist at the University of California, Berkeley, and former editor-in-chief of Proceedings of the National Academy of Sciences. Education Cozzarelli attended Princeton University graduated with an A.B. in biology in 1960. He started graduate training at Harvard Medical School advised by E. C. C. Lin and earned a PhD in biochemistry in 1966. Cozzarelli was appointed a postdoctoral researcher with Arthur Kornberg and purified the T4-phage DNA ligase.

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Nicholas R. Cozzarelli's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. (1977) (676)
DNA gyrase and the supercoiling of DNA. (1980) (604)
Structural transitions and elasticity from torque measurements on DNA (2003) (490)
Topological domain structure of the Escherichia coli chromosome. (2004) (426)
DNA topology and its biological effects (1990) (411)
Topoisomerase IV is a target of quinolones in Escherichia coli. (1995) (360)
Conformational and thermodynamic properties of supercoiled DNA. (1992) (359)
DNA overwinds when stretched (2006) (358)
Biochemical topology: applications to DNA recombination and replication. (1986) (352)
Energy coupling in DNA gyrase and the mechanism of action of novobiocin. (1978) (346)
Probability of DNA knotting and the effective diameter of the DNA double helix. (1993) (342)
Structure of plectonemically supercoiled DNA. (1990) (335)
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. (2002) (329)
Enzymatic synthesis of deoxyribonucleic acid. XXXII. Replication of duplex deoxyribonucleic acid by polymerase at a single strand break. (1970) (321)
13S Condensin Actively Reconfigures DNA by Introducing Global Positive Writhe Implications for Chromosome Condensation (1999) (320)
The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication (1992) (313)
Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth (1979) (304)
Roles of Topoisomerases in Maintaining Steady-state DNA Supercoiling in Escherichia coli * (2000) (304)
Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli (2004) (300)
The mechanism of action of inhibitors of DNA synthesis. (1977) (298)
Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. (1995) (278)
A sign inversion mechanism for enzymatic supercoiling of DNA. (1979) (260)
Simplification of DNA topology below equilibrium values by type II topoisomerases. (1997) (253)
Use of site-specific recombination as a probe of DNA structure and metabolism in vivo. (1987) (252)
Topological challenges to DNA replication: Conformations at the fork (2001) (251)
Positive Torsional Strain Causes the Formation of a Four-way Junction at Replication Forks* (2001) (230)
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. (2000) (226)
Closing the ring: links between SMC proteins and chromosome partitioning, condensation, and supercoiling. (2000) (220)
Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity. (1978) (218)
Discovery of a predicted DNA knot substantiates a model for site-specific recombination. (1985) (214)
Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. (1997) (202)
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. (2000) (197)
Mechanochemical analysis of DNA gyrase using rotor bead tracking (2006) (194)
Sequence-Directed DNA Translocation by Purified FtsK (2005) (191)
Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements. (2000) (187)
Conformational and thermodynamic properties of supercoiled DNA. (1994) (187)
Formation and resolution of DNA catenanes by DNA gyrase (1980) (183)
A genetic selection for supercoiling mutants of Escherichia coli reveals proteins implicated in chromosome structure (2005) (174)
Restoration of Tolerance in Lupus by Targeted Inhibitory Receptor Expression (172)
The Mechanism of Inhibition of Topoisomerase IV by Quinolone Antibacterials* (1998) (171)
The Structure of Supercoiled Intermediates in DNA Replication (1998) (170)
Site-specific cleavage of DNA by E. coli DNA gyrase (1979) (167)
Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases (2003) (167)
PNAS Early Edition. (2000) (155)
Duplex DNA knots produced by Escherichia coli topoisomerase I. Structure and requirements for formation. (1985) (155)
Site-specific relaxation and recombination by the Tn3 resolvase: Recognition of the DNA path between oriented res sites (1983) (147)
Mechanism of topology simplification by type II DNA topoisomerases (2001) (146)
Determination of the absolute handedness of knots and catenanes of DNA (1983) (145)
Catenation of DNA rings by topoisomerases. Mechanism of control by spermidine. (1982) (141)
The stereostructure of knots and catenanes produced by phage λ integrative recombination: implications for mechanism and DNA structure (1985) (141)
The topology of the kinetoplast DNA network (1995) (141)
The effect of ionic conditions on DNA helical repeat, effective diameter and free energy of supercoiling. (1997) (141)
The mechanism of type IA topoisomerases (2002) (133)
Purified RNA polymerase III accurately and efficiently terminates transcription of 5s RNA genes (1983) (133)
Genetic control of the l-α-glycerophosphate system in Escherichia coli (1968) (132)
Contrasting Enzymatic Activities of Topoisomerase IV and DNA Gyrase from Escherichia coli* (1996) (130)
Processive recombination by the phage Mu Gin system: Implications for the mechanisms of DNA strand exchange, DNA site alignment, and enhancer action (1990) (129)
Catenation and knotting of duplex DNA by type 1 topoisomerases: a mechanistic parallel with type 2 topoisomerases. (1981) (126)
Effect of supercoiling on the juxtaposition and relative orientation of DNA sites. (1996) (126)
Prediction of Saccharomyces cerevisiae replication origins (2004) (118)
Identification of oligonucleotide sequences that direct the movement of the Escherichia coli FtsK translocase. (2005) (116)
The intrinsic ATPase of DNA gyrase. (1980) (112)
A minute circular DNA from Escherichia coli 15. (1968) (111)
Independence of replisomes in Escherichia coli chromosomal replication. (2005) (111)
Sequence-directed DNA export guides chromosome translocation during sporulation in Bacillus subtilis (2008) (108)
A topoisomerase from Escherichia coli related to DNA gyrase. (1979) (107)
The effect of ionic conditions on the conformations of supercoiled DNA. II. Equilibrium catenation. (1997) (103)
Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque (2007) (101)
Accumulation of Toxic Concentrations of Methylglyoxal by Wild-Type Escherichia coli K-12 (1974) (100)
Contacts between DNA gyrase and its binding site on DNA: features of symmetry and asymmetry revealed by protection from nucleases. (1981) (96)
Roles of supercoiled DNA structure in DNA transactions (1992) (96)
Modeling of long‐range electrostatic interactions in DNA (1995) (95)
Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability (2004) (93)
Analysis of the mechanism of DNA recombination using tangles (1995) (93)
Interaction of bacteriophage T4 RNA and DNA ligases in joining of duplex DNA at base-paired ends. (1977) (90)
The effect of ionic conditions on the conformations of supercoiled DNA. I. Sedimentation analysis. (1997) (90)
Polynucleotide cellulose as a substrate for a polynucleotide ligase induced by phage T4. (1967) (89)
Growth Stasis by Accumulated l-α-Glycerophosphate in Escherichia coli (1965) (89)
Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange. (1994) (87)
Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication (2005) (86)
The topological mechanism of phage lambda integrase. (1999) (86)
Supercoiled DNA-directed knotting by T4 topoisomerase. (1991) (83)
Determination of the stereostructure of the product of Tn3 resolvase by a general method. (1985) (80)
Isolation of Escherichia coli mRNA and comparison of expression using mRNA and total RNA on DNA microarrays. (2001) (79)
Further genetic and enzymological characterization of the three Bacillus subtilis deoxyribonucleic acid polymerases. (1973) (76)
Bacteriophage T4 RNA ligase. Reaction intermediates and interaction of substrates. (1977) (76)
Enzymic synthesis of DNA. 33. Hydrolysis of a 5'-triphosphate-terminated polynucleotide in the active center of DNA polymerase. (1969) (76)
Escherichia coli type-1 topoisomerases: identification, mechanism, and role in recombination. (1983) (74)
Interaction between DNA gyrase and its cleavage site on DNA. (1980) (72)
Unlinking of DNA by Topoisomerases During DNA Replication (1995) (72)
Induction of specific transcription by RNA polymerase III in transformed cells (1986) (72)
Analysis of strand exchange and DNA binding of enhancer‐independent Gin recombinase mutants. (1993) (71)
Helical repeat and linking number of surface-wrapped DNA. (1988) (70)
DNA gyrase subunit stoichiometry and the covalent attachment of subunit A to DNA during DNA cleavage. (1980) (68)
Structure and activities of Escherichia coli DNA gyrase. (1979) (66)
The binding of gyrase to DNA: analysis by retention by nitrocellulose filters. (1982) (65)
Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance (2003) (63)
Analysis of RNA polymerase III transcription complexes by gel filtration. (1986) (62)
Equilibrium distributions of topological states in circular DNA: interplay of supercoiling and knotting. (1999) (61)
Genetics and Physiology of Bacteriophage T4 3′-Phosphatase: Evidence for Involvement of the Enzyme in T4 DNA Metabolism (1974) (61)
Identification of the FtsK sequence-recognition domain (2006) (61)
Mutational alteration of Bacillus subtilis DNA polymerase 3 to hydroxyphenylazopyrimidine resistance: polymerase 3 is necessary for DNA replication. (1973) (60)
A topological treatment of recombination and topoisomerases. (1984) (59)
Purification and characterization of DNA polymerase III from Bacillus subtilis. (1976) (58)
Monte Carlo analysis of the conformation of DNA catenanes. (1993) (56)
Gin-mediated DNA inversion: product structure and the mechanism of strand exchange. (1988) (56)
Statement on Scientific Publication and Security (2003) (55)
The Saccharomyces cerevisiae Smc2/4 Condensin Compacts DNA into (+) Chiral Structures without Net Supercoiling* (2005) (54)
Cre-lox recombination in Escherichia coli cells. Mechanistic differences from the in vitro reaction. (1992) (54)
SV40 Large T Antigen Hexamer Structure Domain Organization and DNA-Induced Conformational Changes (2002) (54)
Characterization of a new class of deletions of the D region of the bacteriophage T4 genome. (1975) (53)
4 Primer on the Topology and Geometry of DNA Supercoiling (1990) (52)
The absence of supercoiling in kinetoplast DNA minicircles. (1993) (52)
Inhibition of a DNA polymerase from Bacillus subtilis by hydroxyphenylazopyrimidines. (1973) (52)
Contributions of supercoiling to Tn3 resolvase and phage Mu Gin site-specific recombination. (1996) (52)
Recombination site selection by Tn3 resolvase: Topological tests of a tracking mechanism (1985) (51)
DNA-joining enzymes: a review. (1979) (51)
Description of the topological entanglement of DNA catenanes and knots by a powerful method involving strand passage and recombination. (1987) (50)
Comparison of recombination in vitro and in E. coli cells: Measure of the effective concentr ation of DNA in vivo (1995) (50)
Smc5p Promotes Faithful Chromosome Transmission and DNA Repair in Saccharomyces cerevisiae (2006) (49)
Giant proteins that move DNA: bullies of the genomic playground (2006) (48)
Changes in network topology during the replication of kinetoplast DNA. (1995) (48)
Knot what we thought before: the twisted story of replication. (1999) (46)
Altered Deoxyribonucleic Acid Polymerase Activity in a Methyl Methanesulfonate-Sensitive Mutant of Bacillus subtilis (1971) (46)
Bacteriophage T4 RNA ligase: preparation of a physically homogeneous, nuclease-free enzyme from hyperproducing infected cells. (1977) (45)
Gin-mediated recombination of catenated and knotted DNA substrates: Implications for the mechanism of interaction between cis-acting sites (1989) (44)
The Bacterial Condensin MukBEF Compacts DNA into a Repetitive, Stable Structure (2004) (44)
Isolation and characterization of the Tn3 resolvase synaptic intermediate. (1988) (44)
The helical repeat of double-stranded DNA varies as a function of catenation and supercoiling (1988) (43)
Statement on the consideration of biodefence and biosecurity (2003) (41)
Mechanism of strand passage by Escherichia coli topoisomerase I. The role of the required nick in catenation and knotting of duplex DNA. (1985) (40)
Analysis of the structure of dimeric DNA catenanes by electron microscopy. (1995) (39)
Chromosomal Location of the Structural Gene for Glycerol Kinase in Escherichia coli (1966) (37)
Escherichia coli DNA gyrase. (1983) (36)
Geometric arrangements of Tn3 resolvase sites. (1990) (36)
Characterization of Simian Virus 40 T-antigen Double Hexamers Bound to a Replication Fork (2002) (36)
Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine (1976) (35)
Results of a PNAS author survey on an open access option for publication. (2004) (35)
A simple topological method for describing stereoisomers of DNA catenanes and knots. (1984) (34)
Bacteriophage T4 RNA ligase is gene 63 product, the protein that promotes tail fiber attachment to the baseplate. (1977) (34)
Recombination of knotted substrates by Tn3 resolvase. (1989) (33)
Catalysis of DNA joining by bacteriophage T4 RNA ligase. (1976) (30)
Disentangling DNA during replication: a tale of two strands. (2004) (30)
Linear ordering and dynamic segregation of the bacterial chromosome. (2004) (29)
Second Pyridine Nucleotide-Independent l-α-Glycerophosphate Dehydrogenase in Escherichia coli K-12 (1969) (29)
An Open Letter to Elias Zerhouni (2005) (29)
Mechanisms of separation of the complementary strands of DNA during replication (2004) (29)
Uncensored exchange of scientific results (2003) (29)
Topological structure of DNA knots and catenanes. (1992) (28)
Replication of viral DNA in SPO1-infected Bacillus subtilis. I. Replicative intermediates. (1972) (27)
Mechanism of Tn3 resolvase recombination in vivo. (1991) (24)
Bypass of heterology during strand transfer by Saccharomyces cerevisiae Rad51 protein. (2001) (24)
Mechanism of inhibition of Bacillus subtilis DNA polymerase 3 by the arylhydrazinopyrimidine antimicrobial agents. (1974) (23)
The two functional domains of gamma delta resolvase act on the same recombination site: implications for the mechanism of strand exchange. (1990) (22)
Structural and functional properties of Escherichia coli DNA polymerase. (1968) (22)
Bacteriophage T4-Directed DNA Synthesis in Toluene-Treated Cells (1973) (21)
UPSIDE: Uniform principle for sharing integral data and materials expeditiously. (2004) (21)
Supercoiling, knotting, looping and other large-scale conformational properties of DNA (1994) (20)
Purification of the Tn3 transposase and analysis of its binding to DNA. (1981) (18)
PNAS goes weekly in the new year (2004) (17)
GrowthStasis byAccumulated L-aX-Glycerophosphate inEscherichia coli (1965) (17)
The Sep1 strand exchange protein from Saccharomyces cerevisiae promotes a paranemic joint between homologous DNA molecules. (1994) (17)
Power to the people: PubMed Central. (2000) (15)
Bacillus subtilis DNA polymerases. (1974) (15)
An open access option for PNAS. (2004) (14)
Analysis of amplified DNAs from drug-resistant Leishmania by orthogonal-field-alternation gel electrophoresis. The effect of size and topology on mobility. (1989) (14)
Purification of the Gin recombination protein of Escherichia coli phage Mu and its host factor. (1986) (13)
Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations (1978) (13)
Redesign of PNAS: New Covers for the Journal (1999) (13)
Growth stasis by accumulated L-alpha-glycerophosphate in Escherichia coli. (1965) (13)
PNAS policy on publication of sensitive material in the life sciences (2003) (13)
Directed assembly of DNA molecules via simultaneous ligation and digestion. (2007) (13)
Responsible authorship of papers in PNAS. (2004) (12)
Alteration of Escherichia coli Topoisomerase IV Conformation upon Enzyme Binding to Positively Supercoiled DNA* (2006) (12)
Extracellular nucleases of Bacillus subtilis II. The nucleases as 5′-end-group reagents (1974) (12)
Editorial Expression of Concern: Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome (2003) (12)
The helical repeat of underwound DNA in solution. (1988) (11)
Addition of oligonucleotides to the 5'-terminus of DNA by T4 RNA ligase. (1979) (11)
Genetic control of L-alpha-glycerophosphate system in Escherichia coli. (1968) (10)
Crystal structure of an inhibitor and a model for inhibition of replicative DNA synthesis. (1975) (10)
Stereostructure of Replicative DNA Catenanes from Eukaryotic Cells. (1994) (9)
Quantitative analysis of the contributions of enzyme and DNA to the structure of lambda integrative recombinants. (1984) (8)
DNA topoisomerases (1980) (8)
Topoisomerase Action on Short DNA Duplexes Reveals Requirements for Gate and Transfer DNA Segments* (2006) (6)
MECHANISMS OF DNA TOPOISOMERASES (1980) (6)
Liberalization of PNAS copyright policy: noncommercial use freely allowed. (2004) (6)
Editorial Expression of Concern. (2003) (5)
Webcasting is not publication (2003) (5)
Revisiting the independence of the publicly and privately funded drafts of the human genome (2003) (5)
Making research accessible: National Institutes of Health (NIH) public access and PNAS open access policies. (2005) (5)
Contributions of Supercoiling to Tn 3 Resolvase and Phage Mu Gin Site-specific Recombination (4)
A Base Specific Single Heavy Atom Stain for Electron Microscopy (1972) (4)
Unfettered access to published results (2001) (4)
Structure of Reaction Intermediates Formed duringSaccharomyces cerevisiae Rad51-catalyzed Strand Transfer* (2002) (3)
Editorial expression of concern. (2003) (3)
Crystal and molecular structure of 6-(p-hydroxyphenylazo)uracil (1974) (3)
PNAS at volume 100 (2003) (3)
Introduction to "From the Academy". (1997) (2)
The structure and function of DNA supercoiling and catenanes. (1991) (2)
Redesign of PNAS: getting ready for the millennium. (1999) (2)
CONFORMATIONAL AND THERMODYNAMIC (1994) (2)
For Free Access, Follow the Brick Red Buttons (2001) (2)
National Academy of Sciences endorses National Institutes of Health plan for enhanced access to research information. (2004) (2)
Lower open access fees and institutional partnerships. (2004) (1)
Erratum: Uncensored exchange of scientific results (Proceedings of the National Academy of Sciences (2003) 100, 4, (1464) DOI: 10.1073/pnas.0630491100) (2012) (1)
Bacteriophage T 4 RNA Ligase (1)
OF INHIBITORS OF DNA SYNTHESISl (1977) (1)
1 – DNA-Joining Enzymes: A Review (1989) (1)
PNAS gives free online access to developing countries (2002) (1)
DNA helical repeats (1989) (1)
Supplementary Material Can Now Appear Online (1998) (0)
Making back issues of PNAS online free. (2000) (0)
Packing defects as selectivity switches for drug-based protein inhibitors. (2006) (0)
PNAS publishes daily online (2002) (0)
Abstracts of papers presented at the 1986 Meeting on Biological Effects of DNA Topology, September 17-September 21 (1986) (0)
PNAS Profiles: How do Academy members get started in science? (2005) (0)
Mechanisms of DNA replication and recombination : proceedings of a UCLA symposium held in Keystone, Colorado, April 3-9, 1983 (1983) (0)
Preface/Front Matter (1990) (0)
Mechanism of type 1 topo isomerases (1983) (0)
Nucleic Ac ids Research DNA gyrase subunit stoichiometry and tbe covalent attachment of subunit A to DNA during DNA cleavage (2005) (0)
Mechanism ofInhibition ofBacillus subtilis DNA Polymerase IIIbythe Arylhydrazinopyrimidine Antimicrobial Agents (ternary complex/exonuclease/DNA replication/base pairing/polyamine) (1974) (0)
Roles of to~oisomerase IV and DNA gyrask in DNA unlinkin a during replication in Escheric ia coli (2007) (0)
Retraction (2005) (0)
Table of Contents (1993) (0)
Augmented sequence profile of known and predicted yeast replication origins (2011) (0)
Determination ofthestereostructure oftheproduct ofTn3 resolvase byageneral method (1985) (0)
In Memoriam: PNAS Editor-in-Chief (2006) (0)
Purification oftheTh3 Transposase andAnalysis ofIts Binding toDNA (1981) (0)
Biographies of newly elected Academy members (2003) (0)
Bacteriophage T4RNA ligase isgene63product, theprotein that promotes tail fiber attachment tothebaseplate (multifunctional protein) (1977) (0)
Editor's note (2005) (0)
Wider sharing of materials and methods (1985) (0)

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